Diana Cocioabă, Alexandra I Fonseca, Radu Leonte, Ivanna Hrynchak, Roxana Tudoroiu-Cornoiu, Sergio J C do Carmo, Bogdan Burghelea, Simona Băruță, Ana Rita Almeida, Radu Șerban, Anca Dinischiotu, Antero J Abrunhosa, Dana Niculae
On the verge of a theranostic approach to personalised medicine, copper-64 is one of the emerging radioisotopes in nuclear medicine due to its exploitable nuclear and biochemical characteristics. The increased demand for copper-64 for preclinical and clinical studies has prompted the development of production routes. This research aims to compare the (p,n) reaction on nickel-64 solid versus liquid targets and evaluate the effectiveness of [64 Cu]CuCl2 solutions prepared by the two routes. As new treatments for neurotensin receptor-overexpressing tumours have developed, copper-64 was used to radiolabel Neurotensin (8-13) and Neuromedin N...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry