Shamez N Ladhani, Alexander C Dowell, Scott Jones, Bethany Hicks, Cathy Rowe, Jusnara Begum, Dagmar Wailblinger, John Wright, Stephen Owens, Ailsa Pickering, Benjamin Shilltoe, Paddy McMaster, Elizabeth Whittaker, Jianmin Zuo, Annabel Powell, Gayatri Amirthalingam, Sema Mandal, Jamie Lopez-Bernal, Mary E Ramsay, Neave Kissane, Michael Bell, Heather Watson, David Ho, Bassam Hallis, Ashley Otter, Paul Moss, Jonathan Cohen
BACKGROUND: In response to a national mpox (formerly known as monkeypox) outbreak in England, children exposed to a confirmed mpox case were offered modified vaccinia Ankara-Bavaria Nordic (MVA-BN), a third-generation smallpox vaccine, for post-exposure prophylaxis. We aimed to assess the safety and reactogenicity and humoral and cellular immune response, following the first reported use of MVA-BN in children. METHODS: This is an assessment of children receiving MVA-BN for post-exposure prophylaxis in response to a national mpox outbreak in England...
June 16, 2023: Lancet Infectious Diseases