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https://www.readbyqxmd.com/read/28207342/cumulative-lifetime-marijuana-use-and-incident-cardiovascular-disease-in-middle-age-the-coronary-artery-risk-development-in-young-adults-cardia-study
#1
Jared P Reis, Reto Auer, Michael P Bancks, David C Goff, Cora E Lewis, Mark J Pletcher, Jamal S Rana, James M Shikany, Stephen Sidney
OBJECTIVES: To investigate the effects of marijuana in the development of incident cardiovascular and cerebrovascular outcomes. METHODS: Participants were 5113 adults aged 18 to 30 years at baseline (1985-1986) from the Coronary Artery Risk Development in Young Adults study, who were followed for more than 25 years. We estimated cumulative lifetime exposure to marijuana using repeated assessments collected at examinations every 2 to 5 years. The primary outcome was incident cardiovascular disease (CVD) through 2013...
February 16, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28206689/working-memory-ability-and-early-drug-use-progression-as-predictors-of-adolescent-substance-use-disorders
#2
Atika Khurana, Daniel Romer, Laura M Betancourt, Hallam Hurt
AIMS: To test a neurobehavioral model of adolescent substance use disorder (SUD) resulting from an imbalance between a hyperactive reward motivation system and a hypoactive executive control system. Specifically, we tested (1) if early weakness in working memory (WM) and associated imbalance indicators of acting-without-thinking (AWT) and delay discounting (DD) predict SUD in late adolescence, and (2) if early drug use progression mediates this relation. DESIGN: Five waves of longitudinal data collected annually from 2005-2010, with a final follow-up in 2012...
February 16, 2017: Addiction
https://www.readbyqxmd.com/read/28202303/association-between-substance-use-diagnoses-and-psychiatric-disorders-in%C3%A2-an-adolescent-and-young-adult-clinic-based-population
#3
Justine Wittenauer Welsh, John R Knight, Sherry Shu-Yeu Hou, Monica Malowney, Patricia Schram, Lon Sherritt, J Wesley Boyd
PURPOSE: Adolescents with substance use disorders are more likely to have a current psychiatric disorder. However, when compared with the adult literature, there is relatively limited information regarding the specific co-occurrence of certain mental health diagnoses and substance use disorders in adolescents. The objectives of this study were to build on the previous literature regarding mental health diagnoses and different types of substance use disorders in adolescents, as well as explore the differences, if any, between groupings of mental health diagnosis and type of substance used...
February 12, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28196428/the-association-of-psychedelic-use-and-opioid-use-disorders-among-illicit-users-in-the-united-states
#4
Vincent D Pisano, Nathaniel P Putnam, Hannah M Kramer, Kevin J Franciotti, John H Halpern, Selma C Holden
BACKGROUND: Preliminary studies show psychedelic compounds administered with psychotherapy are potentially effective and durable substance misuse interventions. However, little is known about the association between psychedelic use and substance misuse in the general population. This study investigated the association between psychedelic use and past year opioid use disorders within illicit opioid users. METHODS: While controlling for socio-demographic covariates and the use of other substances, the relationship between classic psychedelic use and past year opioid use disorders was analyzed within 44,000 illicit opioid users who completed the National Survey on Drug Use and Health from 2008 to 2013...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28194606/sexual-partner-typologies-and-the-association-between-drug-use-and-sexual-risk-behavior-among-young-men-who-have-sex-with-men
#5
Patrick Janulis, Brian A Feinstein, Gregory Phillips, Michael E Newcomb, Michelle Birkett, Brian Mustanski
Numerous partner and relationship characteristics are associated with sexual risk behavior among young men who have sex with men (YMSM), including being in a serious relationship and having older partners. However, most research in this area is limited by its reliance on variable-centered approaches. Using multilevel latent class analysis, this study identified subgroups of sexual partner types with a particular emphasis on examining whether partner type moderated the association between drug use and condomless anal sex (CAS)...
February 13, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28190698/therapeutic-effects-of-cannabinoids-in-animal-models-of-seizures-epilepsy-epileptogenesis-and-epilepsy-related-neuroprotection
#6
REVIEW
Evan C Rosenberg, Pabitra H Patra, Benjamin J Whalley
The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. In particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, prompting a particularly active area of preclinical research into the therapeutic potential of plant cannabinoids in epilepsy. Since that time, a large body of literature has accumulated describing the effects of several of the >100 individual plant cannabinoids in preclinical models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection...
February 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28188220/cannabinoids-activate-monoaminergic-signaling-to-modulate-key-c-elegans-behaviors
#7
Mitchell Oakes, Wen Jing Law, Tobias Clark, Bruce Bamber, Richard Komuniecki
Cannabis or marijuana, a popular recreational drug, alters sensory perception and exerts a range of potential medicinal benefits. The present study demonstrates that the endogenous cannabinoid receptor agonists, 2-arachidonoylglycerol (2-AG) and anandamide (AEA) activate a canonical cannabinoid receptor in C. elegans and also modulate monoaminergic signaling at multiple levels. 2-AG or AEA inhibit nociception and feeding through a pathway requiring the cannabinoid-like receptor, NPR-19. 2-AG or AEA activate NPR-19 directly and cannabinoid-dependent inhibition can be rescued in npr-19 null animals by the expression of a human cannabinoid receptor, CB1, highlighting the orthology of the receptors...
February 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28188044/cannabinoids-in-treatment-resistant-epilepsy-a-review
#8
REVIEW
Brooke K O'Connell, David Gloss, Orrin Devinsk
Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been used to treat epilepsy for millennia, but only in the last few years have we begun to collect data from adequately powered placebo-controlled, randomized trials (RCTs) with cannabidiol (CBD), a cannabis derivative. Previously, information was limited to case reports, small series, and surveys reporting on the use of CBD and diverse medical marijuana (MMJ) preparations containing: tetrahydrocannabinol (THC), CBD, and many other cannabinoids in differing combinations...
February 7, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28182979/gender-differences-in-the-association-between-conduct-disorder-and-risky-sexual-behavior
#9
Stephanie Brooks Holliday, Brett A Ewing, Erik D Storholm, Layla Parast, Elizabeth J D'Amico
Despite suggestions that there are gender differences in the association between conduct disorder (CD) and risky sexual behavior, limited empirical research has examined this question. Youth (N = 616) were recruited from four primary care clinics and completed questions related to risky sexual behavior, alcohol and marijuana use, and CD. Results of stratified multivariate models indicated that the association between CD and having four or more lifetime partners, having two or more partners in the last 3 months, and engaging in condomless sex was stronger among female youth...
February 6, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28182448/when-alcohol-is-only-part-of-the-problem-an-event-level-analysis-of-negative-consequences-related-to-alcohol-and-other-substance-use
#10
Kimberly A Mallett, Rob Turrisi, Brittney A Hultgren, Nichole Sell, Racheal Reavy, Michael Cleveland
While alcohol remains the drug of choice for most college students, national data show that 40% of college students also use other substances (e.g., marijuana, cocaine, etc.). Longitudinal studies indicate that students who report use of both alcohol and other substances experience more consequences (e.g., blackout, arrests). The current study expands upon this research by using a multilevel approach to examine average and event-level alcohol combined with other substance use (ALC+) and its role on consequences experienced...
February 9, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28180899/trends-in-and-characteristics-of-marijuana-and-menthol-cigarette-use-among-current-cigarette-smokers-2005-2014
#11
Gillian L Schauer, Erica N Peters, Zachary R Rosenberry, Hyoshin Kim
No abstract text is available yet for this article.
January 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28174520/modulation-of-human-peripheral-blood-mononuclear-cell-signaling-by-medicinal-cannabinoids
#12
Wesley K Utomo, Marjan de Vries, Henri Braat, Marco J Bruno, Kaushal Parikh, Mònica Comalada, Maikel P Peppelenbosch, Harry van Goor, Gwenny M Fuhler
Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory properties of medical cannabis. Healthy volunteers were asked to ingest medical cannabis, and kinome profiling was used to generate comprehensive descriptions of the cannabis challenge on inflammatory signal transduction in the peripheral blood of these volunteers...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28171805/beyond-joints-and-brownies-marijuana-concentrates-in-the-legal-landscape-of-wa-state
#13
Beatriz H Carlini, Sharon B Garrett, Robin M Harwick
No abstract text is available yet for this article.
February 4, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28170389/pediatric-collateral-damage-from-recreational-marijuana-use
#14
Scott A Rivkees
No abstract text is available yet for this article.
February 7, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28170098/enhancing-social-support-postincarceration-results-from-a-pilot-randomized-controlled-trial
#15
Carrie Pettus-Davis, Allison Dunnigan, Christopher A Veeh, Matthew Owen Howard, Anna M Scheyett, Amelia Roberts-Lewis
OBJECTIVE: Over 50% of released prisoners are reincarcerated within 3 years. Social support from loved ones postincarceration significantly reduces the likelihood of reincarceration. Increasingly, intervention developers aim to implement interventions that will enhance the stability of support available. This study responds to gaps in knowledge. METHOD: The current efficacy study reports findings from a randomized controlled trial (n = 57) of a social support intervention...
February 7, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28169144/the-legal-status-of-cannabis-marijuana-and-cannabidiol-cbd-under-u-s-law
#16
REVIEW
Alice Mead
In the United States, federal and state laws regarding the medical use of cannabis and cannabinoids are in conflict and have led to confusion among patients, caregivers, and healthcare providers. Currently, cannabis is legal for medical purposes in 50% of the states, and another seventeen states allow products that are high in cannabidiol (CBD) and low in THC (tetrahydrocannabinol) for medical use. Many of these artisanal products are sold in dispensaries or over the internet. However, none of these products has been approved by the Food and Drug Administration (FDA)...
February 3, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28165233/the-bibenzyl-canniprene-inhibits-the-production-of-pro-inflammatory-eicosanoids-and-selectively-accumulates-in-some-cannabis-sativa-strains
#17
Gianna Allegrone, Federica Pollastro, Gianmaria Magagnini, Orazio Taglialatela-Scafati, Julia Seegers, Andreas Koeberle, Oliver Werz, Giovanni Appendino
Canniprene (1), an isoprenylated bibenzyl unique to Cannabis sativa, can be vaporized and therefore potentially inhaled from marijuana. Canniprene (1) potently inhibited the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50 0.4 μM) and also affected the generation of prostaglandins via the cyclooxygenase/microsomal prostaglandin E2 synthase pathway (IC50 10 μM), while the related spiranoid bibenzyls cannabispiranol (2) and cannabispirenone (3) were almost inactive in these bioassays...
February 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28163563/testing-a-brief-substance-misuse-preventive-intervention-for-parents-of-pre-adolescents-feasibility-acceptability-preliminary-efficacy
#18
Margie R Skeer, Konstantina E Yantsides, Misha Eliasziw, Allison Carlton-Smith, Migdalia Tracy, Anthony Spirito
Evidence-based interventions to reduce substance misuse among adolescents are resource and time intensive. We conducted a pilot RCT to evaluate a novel, adaptable, and resource-efficient substance misuse preventive intervention for parents/guardians, focusing on talking with children about substance use and on eating family meals. We randomized 70 parents of children in third-through-sixth grades within a large, urban public school system in New England to the intervention or control condition. Over a six-month follow-up period, we assessed feasibility and acceptability of the intervention and examined frequency of parent-child conversations about alcohol, marijuana, and other drugs, and frequency and duration of family meals...
December 2016: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/28162799/cannabidiol-swinging-the-marijuana-pendulum-from-weed-to-medication-to-treat-the-opioid-epidemic
#19
Yasmin L Hurd
Epidemics require a paradigm shift in thinking about all possible solutions. The rapidly changing sociopolitical marijuana landscape provides a foundation for the therapeutic development of medicinal cannabidiol to address the current opioid abuse crisis.
February 2, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28162792/synthetic-pot-not-your-grandfather-s-marijuana
#20
REVIEW
Benjamin M Ford, Sherrica Tai, William E Fantegrossi, Paul L Prather
In the early 2000s in Europe and shortly thereafter in the USA, it was reported that 'legal' forms of marijuana were being sold under the name K2 and/or Spice. Active ingredients in K2/Spice products were determined to be synthetic cannabinoids (SCBs), producing psychotropic actions via CB1 cannabinoid receptors, similar to those of Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the primary active constituent in marijuana. Often abused by adolescents and military personnel to elude detection in drug tests due to their lack of structural similarity to Δ(9)-THC, SCBs are falsely marketed as safe marijuana substitutes...
January 27, 2017: Trends in Pharmacological Sciences
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