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Uterine fibroids

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https://www.readbyqxmd.com/read/28540824/establishment-of-a-scoring-system-for-predicting-the-difficulty-level-of-high-intensity-focussed-ultrasound-ablation-of-uterine-fibroids
#1
Zhongqiong Liu, Chunmei Gong, Yunchang Liu, Lian Zhang
PURPOSE: To establish a scoring system that predicts the difficulty level of high-intensity focussed ultrasound (HIFU) ablation of uterine fibroids. MATERIALS AND METHODS: Four hundred and twenty-two patients with fibroids were enrolled. The energy efficiency factor (EEF) and sonication time were set as dependent variables, with factors possibly affecting EEF and sonication time including age, body mass index (BMI), the volume of fibroids, the location of the uterus, the type of fibroids, the signal intensity on the T2-weighted imaging (T2WI), the enhancement type, the thickness of the rectus abdominis and the subcutaneous fat layer, the distance from the anterior/posterior surface of the fibroid to the skin, and the abdominal wall scars were set as predictors for building optimal scaling regression models...
May 19, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28536870/benign-metastasizing-leiomyomas-following-myomectomy-and-uterine-artery-embolization
#2
Jessica Yoon, James B Spies, Theresa M Caridi
Benign metastasizing leiomyomas (BMLs) are rare sequelae of common uterine leiomyomas and most frequently found in the lungs. Most cases of BMLs occur with a history of prior gynecologic procedures; however, none have yet been reported in association with uterine artery embolization (UAE). This case report highlights the disease course for a 48-yo female with a history of both myomectomy and UAE for uterine fibroids who presented later with bilateral pulmonary BMLs. Though the pathophysiology of BMLs is poorly understood and this case is confounded by prior myomectomy, it does bring into question whether UAE has a role in BML development...
May 23, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28534020/incarceration-of-a-pedunculated-uterine-fibroid-in-an-umbilical-hernia
#3
Mi Ju Kim, Hyun-Hwa Cha, Won Joon Seong
Uterine fibroids are common benign tumors that may cause an umbilical hernia in patients with increased intra-abdominal pressure due to pregnancy, obesity, ascites, and intra-abdominal tumors. However, the simultaneous occurrence of uterine fibroids and umbilical hernias, or fibroids and an associated umbilical hernia, during pregnancy has rarely been reported. Here, we present the case of a fibroid presenting as an incarcerated umbilical hernia in a menopausal patient.
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28523429/kir-lilrb-and-their-ligands-genes-as-potential-biomarkers-in-recurrent-implantation-failure
#4
REVIEW
Izabela Nowak, Karolina Wilczyńska, Jacek R Wilczyński, Andrzej Malinowski, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk
Reproductive failure in humans is a very important social and economic problem, because nowadays women decide to conceive later in life and delay motherhood. Unfortunately, with increasing age they have less chance for natural fertilization and maintenance of pregnancy. Many of them need assisted reproductive technology. Approximately 10% of women after in vitro fertilization-embryo transfers experience recurrent implantation failure (RIF). Multiple factors may contribute to RIF, including oocyte and sperm quality, parental chromosomal anomalies, genetic or metabolic abnormalities of the embryo, poor uterine receptivity, immunological disturbances in the implantation site, and some gynecologic pathologies such as endometriosis, uterine fibroids, hydrosalpinx and endometrial polyps...
May 18, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28523198/uterine-fibroid-torsion-during-pregnancy-a-case-of-laparotomic-myomectomy-at-18-weeks-gestation-with-systematic-review-of-the-literature
#5
Annachiara Basso, Mariana Rita Catalano, Giuseppe Loverro, Serena Nocera, Edoardo Di Naro, Matteo Loverro, Mariateresa Natrella, Salvatore Andrea Mastrolia
Uterine myomas are the most common benign growths affecting female reproductive system, occurring in 20-40% of women, whereas the incidence rate in pregnancy is estimated from 0.1 to 3.9%. The lower incidence in pregnancy is due to the association with infertility and low pregnancy rates and implantation rates after in vitro fertilization treatment. Uterine myomas, usually, are asymptomatic during pregnancy. However, occasionally, pedunculated fibroids torsion or other superimposed complications may cause acute abdominal pain...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28516272/uterine-artery-embolization-for-symptomatic-adenomyosis-7-year-clinical-follow-up-using-ufs-qol-questionnaire
#6
Annefleur M de Bruijn, Marieke Smink, Wouter J K Hehenkamp, Robbert J Nijenhuis, Albert J Smeets, Focco Boekkooi, Paul J H M Reuwer, Willem J Van Rooij, Paul N M Lohle
PURPOSE: The purpose of this study was to assess clinical outcomes 7 years after uterine artery embolization (UAE) in the treatment of symptomatic adenomyosis. MATERIALS AND METHODS: In this prospective cohort study, one specialized hospital in the Netherlands recruited patients with symptomatic adenomyosis or adenomyosis in combination with fibroids for UAE. The 7-year post-intervention outcomes were health-related quality of life (HRQOL), symptom severity scores (SSS), satisfaction, menopause and re-interventions...
May 17, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28498567/uterine-fibroids-from-observational-epidemiology-to-clinical-management
#7
Paolo Vercellini, Maria Pina Frattaruolo
According to this systematic review of epidemiological studies, fibroid prevalence varied widely, with no consistent association across studies between observed estimates and country, methodology, and population. Fibroid incidence was higher in black than in white women independently of other risk factors, suggesting a racial predisposition. A genetic influence was confirmed also by the association with a positive family history. The association with age and menopausal status maybe interpreted in terms of varying degrees of oestrogen exposure, which could explain also the association with food additives and soybean consumption...
May 12, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28498262/sarcoma-risk-in-uterine-surgery-in-a-tertiary-university-hospital-in-germany
#8
Sudip Kundu, Manuel Zachen, Hermann Hertel, Peter Hillemanns, Philipp Soergel
OBJECTIVES: There is a risk to incidentally spread uterine malignancies, especially sarcoma, if tissue is morcellated during hysterectomy or myoma enucleation. In the last years, a worldwide discussion has been started about this problem. However, the risk seems to be very small in recent studies. This study aims at further investigating the risk of disseminating uterine malignancy during uterine surgery in a tertiary university hospital in Germany. METHODS: In a retrospective setting, all cases of uterine myometrial surgery (hysterectomies and myomectomies) in our clinic during a period of 10 years were identified using clinical databases...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498002/an-observation-study-of-the-clinical-evaluation-of-symptom-relief-and-side-effects-associated-with-taking-ulipristal-acetate-esmya-including-its-effect-on-pre-menstrual-syndrome
#9
Bee F Chen, Martin C Powell, Courtney O'Beirne
This was an observational study investigating the efficacy and side effects associated with ulipristal acetate (UPA), a progesterone receptor modulator, and the possible benefits to women who have co-existing pre-menstrual syndrome (PMS). 80 women returned a questionnaire on the bleeding, menstrual pain and side effects, and changes on PMS were recorded. 67 women (84%) showed improvement in their menses. 54 women (67%) became amenorrhoeic. Of those, 67% were within 10 days of commencing UPA. Menses returned in 33 amenorrhoeic women within 4 weeks of stopping UPA...
May 12, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28494269/medical-conditions-associated-with-recurrent-miscarriage-is-bmi-the-tip-of-the-iceberg
#10
Mushi J Matjila, Anne Hoffman, Zephne M van der Spuy
BACKGROUND: In contrast to sporadic miscarriage, recurrent miscarriage (RM) is a rare entity which affects 1% of couples attempting conception. It is distressing for couples and healthcare professionals as the aetiology is unclear with limited treatment options. Apart from anti-phospholipid syndrome (APS), the strength of associations between RM and commonly investigated endocrine, autoimmune, thrombophilic and uterine structural abnormalities remains uncertain and variable. OBJECTIVES: To assess the prevalence of commonly investigated medical conditions associated with RM...
May 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28487176/feasibility-of-reduced-port-robotic-surgery-for-myomectomy-with-the-da-vinci-%C3%A2-surgical-system
#11
Jeong Jin Kim, Chahien Choi, Su Hyun Nam, Woo Young Kim
STUDY OBJECTIVE: To present our initial experience with reduced port robotic surgery (RPRS) for myomectomy using Octo-Port. DESIGN: Prospective and noncomparative study. (Canadian Task Force classification II-3). SETTING: University hospital. PATIENTS: Nineteen consecutive patients with symptomatic uterine fibroids desiring conservative minimally invasive robotic surgery from October 2015 to December 2016 INTERVENTIONS: An 8...
May 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28485851/fibroid-vascularisation-as-a-predictor-for-uterine-fibroid-growth
#12
Margit Dueholm
There is a large variation in fibroid growth such that fibroids may grow at vastly different rates and conversely may spontaneously regress. The ability to predict the growth of fibroids could help clinicians decide, with their patients, the need for treatment. For example, asymptomatic women with fibroids detected incidentally may require follow up if these fibroids are predicted to have a high growth rate. In women of reproductive age, fast-growing fibroids located in a submucous or intramural position may subsequently impair fertility and so early surgical removal should be considered...
May 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28483502/oxidative-stress-a-key-regulator-of-leiomyoma-cell-survival
#13
Nicole M Fletcher, Mohammed S Abusamaan, Ira Memaj, Mohammed G Saed, Ayman Al-Hendy, Michael P Diamond, Ghassan M Saed
OBJECTIVE: To determine the effects of attenuating oxidative stress with the use of dichloroacetate (DCA) on the expression of key redox enzymes myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) as well as on apoptosis. DESIGN: Prospective experimental study. SETTING: University medical center. PATIENT(S): Cells established from myometrium and uterine fibroid from the same patients. INTERVENTION(S): Cells were exposed to normal (20% O2) or hypoxic (2% O2) conditions for 24 hours with or without DCA (20 μg/mL), a metabolic modulator that shifts anaerobic to aerobic metabolism...
May 5, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28482329/endometrial-changes-during-ulipristal-acetate-use-a-systematic-review
#14
REVIEW
Inge De Milliano, Dominique Van Hattum, Johannes C F Ket, Judith A F Huirne, Wouter J K Hehenkamp
Ulipristal acetate is increasingly used for several clinical indications, like emergency contraception and pre-treatment of uterine fibroids. It has mixed progesterone agonist and antagonist effects in the myometrium and endometrium. Due to its progesterone antagonistic effect, an unopposed estrogen effect could occur which could cause (pre-)malignant lesions in the endometrium. Several studies have been performed to evaluate this possible increased risk for endometrial malignancies when using ulipristal acetate...
April 28, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28481444/when-east-meets-west
#15
Qide Han
In the current issue of BJOG, a report titled "Evaluation of HIFU Ablation for Uterine Fibroids: an IDEAL Prospective Exploration Study", was led by Professor Jinghe Lang, a member of Chinese Academy of Technology. While Chinese researchers have been leading the R&D of High-intensity focused ultrasound surgery technology and its clinical applications for more than 20 years, worldwide clinical dissemination has been hindered by the lack of systematic and high quality clinical evaluation. The study by Lang et al...
May 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28479892/chemical-constituents-of-cyperus-rotundus-l-and-their-inhibitory-effects-on-uterine-fibroids
#16
Ju Ying, Xiao Bing
BACKGROUND: Xiang Fu (Cyperus rotundus L) enters the liver, spleen and triple warmer meridians, and has qi stagnation-removing, qi circulation-promoting, menstruation-regulating and pain-relieving effects. Besides, it can improve ovarian function, and has hypolipidemic, hypoglycemic and neuroprotective actions. OBJECTIVES: To study the biflavone constituents in Cyperus rotundus L and to investigate the effect and mechanism of amentoflavone on inhibition of uterine tumors...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28478727/local-upregulation-of-transient-receptor-potential-ankyrin-1-and-transient-receptor-potential-vanilloid-1-ion-channels-in-rectosigmoid-deep-infiltrating-endometriosis
#17
Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán
Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators. They are also present on the rat endometrium in an oestrogen-regulated manner. TRPV1 is upregulated in peritoneal and ovarian endometriosis patients, but there is no information about TRPA1 and their pathophysiological significances. In this study, patients undergoing laparoscopic surgery were investigated: severe dysmenorrhoea due to rectosigmoid deep infiltrating endometriosis ( n = 15), uterine fibroid-induced moderate dysmenorrhoea ( n = 7) and tubal infertility with no pain ( n = 6)...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28472862/three-dimensional-saline-infusion-sonography-compared-to-two-dimensional-saline-infusion-sonography-for-the-diagnosis-of-focal-intracavitary-lesions
#18
REVIEW
Lotte L Nieuwenhuis, Frederik Jr Hermans, A J Marjolein Bij de Vaate, Mariska Mg Leeflang, Hans Am Brölmann, Wouter Jk Hehenkamp, Ben Willem J Mol, T Justin Clark, Judith Af Huirne
BACKGROUND: Focal abnormalities most commonly acquired within the uterine cavity include endometrial polyps (arising from the endometrium) and submucous fibroids (arising from the myometrium). These benign abnormalities can cause several problems, including abnormal uterine bleeding (AUB) and subfertility. Two-dimensional saline infusion sonography (2D SIS) is a minimally invasive test that can be used to diagnose these pathologies, but it is less accurate than hysteroscopy, which is a more invasive procedure by which an endoscope allows direct visualisation of the uterine cavity...
May 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28471125/the-association-between-clinical-parameters-and-uterine-fibroid-size-in-patients-who-underwent-abdominal-myomectomy
#19
Mehmet Çınar, Rıfat Taner Aksoy, Ali İrfan Güzel, Aytekin Tokmak, Okan Yenicesu, Esma Sarıkaya, Özlem Evliyaoğlu
OBJECTIVES: To evaluate if there is an association between neutrophil lymphocyte ratio and tumor markers in patients with uterine fibroids. METHODS: A total of three hundred and fifty seven patients who operated for myomectomy were enrolled this retrospective case control study. Risk factors evaluated were; age, uterine fibroid type, body mass index (BMI), gravidity, parity, preoperative and postoperative hemoglobin difference, neutrophil/lymphocyte ratio (NLR), alpha fetoprotein (AFP), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9), cancer antigen 15-3 (CA 15-3), carsino embryonic antigen (CEA) levels...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28463949/characterization-and-preoperative-risk-analysis-of-leiomyosarcomas-at-a-high-volume-tertiary-care-center
#20
Ann Peters, Amanda M Sadecky, Daniel G Winger, Richard S Guido, Ted T M Lee, Suketu M Mansuria, Nicole M Donnellan
INTRODUCTION: Uterine morcellation in minimally invasive surgery has recently come under scrutiny because of inadvertent dissemination of malignant tissue, including leiomyosarcomas commonly mistaken for fibroids. Identification of preoperative risk factors is crucial to ensure that oncologic care is delivered when suspicion for malignancy is high, while offering minimally invasive hysterectomies to the remaining patients. OBJECTIVES: The aim of this study was to characterize risk factors for uterine leiomyosarcomas by reviewing preoperative, intraoperative, and postoperative data with an emphasis on the presence of concurrent fibroids...
May 2, 2017: International Journal of Gynecological Cancer
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