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Uterine fibroids

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https://www.readbyqxmd.com/read/29780783/doppler-sonography-of-perifibroid-and-intrafibroid-arteries-of-uterine-leiomyomas
#1
Bukunmi Michael Idowu, Bolanle Olubunmi Ibitoye
Objective: To sonographically evaluate the dominant fibroid nodule vascularity and flow velocity pattern of perifibroid and intrafibroid arteries. Methods: We recruited 140 women with uterine fibroids. Their uteri were scanned to determine the vascularity of fibroid nodules and the Doppler indices of the fibroid arteries. Results: The median volume of the dominant leiomyoma nodule was 133 cm3 (range=1.5-2,575 cm3 ). Eighty-three subjects (59...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29778379/non-coding-rnas-an-important-regulatory-mechanism-in-pathogenesis-of-uterine-fibroids
#2
EDITORIAL
Qiwei Yang, Ayman Al-Hendy
No abstract text is available yet for this article.
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29777846/an-academic-tertiary-referral-center-s-experience-with-a-vascular-surgery-based-uterine-artery-embolization-program
#3
Naiem Nassiri, Adrian Balica, Nolan C Cirillo-Penn, Dustin Tyler Crystal, Gloria A Bachmann
OBJECTIVE: Despite growing endovascular experience within the vascular surgery community, some catheter-based interventions - such as uterine artery embolization (UAE) - remain outside the clinical scope of most vascular surgeons, owing in part to established referral patterns and limited awareness among referring colleagues. We present our experience with a vascular surgery-based, multidisciplinary UAE program at an academic tertiary referral center. METHODS: In a collaborative effort between vascular surgery and gynecology, a Pelvic Vascular Disease Program has been established to provide palliative, prophylactic, and therapeutic embolizations including, but not limited to, UAE...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29772408/hysteroscopic-myomectomy-of-a-large-submucosal-leiomyoma-with-novel-use-of-fluid-warming
#4
Tess Chase, Stephanie J Estes
Uterine fibroid size is often considered a limiting factor for considering the surgical approach to myomectomy. In this case, a 35-year-old woman presented with heavy menstrual bleeding and desire for fertility. An ultrasound three months prior could not assess the endometrium and suggested leiomyoma. Magnetic resonance imaging of the pelvis identified a fundal submucosal myoma measuring 6.8 × 7.1 × 3.5 cm. A planned staged hysteroscopic resection of the large submucosal fibroid with intramural component was achieved...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29765929/gonadotropin-releasing-hormone-agonist-plus-aromatase-inhibitor-in-the-treatment-of-uterine-leiomyoma-in-near-menopause-patient-a-case-series-study
#5
Sanam Moradan
Objectives: There are many drugs for of symptomatic fibroids. Gonadotropin-releasing hormone (GnRH) agonists are the well known drugs. Also, aromatase inhibitors are effective. All published studies surveyed the effect of one of these two drugs. In this study as the first study decided to evaluate the effectiveness of the combination of GnRH agonists + aromatise inhibitor on the uterine fibroids. Methods: A cross-sectional prospective case series study was performed on 10 known cases of uterine fibroids late perimenopause, at least 3 myomas >5 cm, abnormal uterine bleeding and anemia due to fibroids, candidate for hysterectomy, no tendency to surgery...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29765254/stump-a-surprise-finding-in-a-large-fibroid-uterus-in-a-20-year-old-woman
#6
Lara Hughes, Alphonse Roex, Anupam Parange
We report on a case of a 20-year-old nulliparous woman with menorrhagia associated with a smooth muscle tumor of uncertain malignant potential (STUMP) that was responsive to Goserelin. This case details the investigation and management of a young woman who desires ongoing fertility preservation. STUMP is a rare uterine tumor with a paucity of literature available regarding management and subsequent malignant potential, particularly in the case of a patient who desires fertility preservation.
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29763581/intraoperative-ultrasound-assisted-enucleation-of-residual-fibroids-following-laparoscopic-myomectomy
#7
Yan Hao, Si-Jing Li, Ping Zheng, Xia Wu, Jie Sheng, Dong-Lan Yuan, Qi Zhou, Wei Wei, Ai-Hong Duan, Qing-Qing Wu, Dan Lu
AIM: To investigate if intraoperative ultrasounds by laparoscopic and transvaginal ultrasonography (LUS and TVS) could improve enucleating the residual fibroids following laparoscopic myomectomy (LM). METHODS: From March to December 2016, 78 women with uterine fibroids underwent LM, LUS and TVS were applied to detect residual fibroids and to guide surgeons to enucleate them after the visible fibroids were removed during LM operation. RESULTS: The total number of residual fibroids found by LUS was 140, and the total number found by TVS was 127 following LM (P = 0...
May 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29750955/the-comparing-options-for-management-patient-centered-results-for-uterine-fibroids-compare-uf-registry-rationale-and-design
#8
Elizabeth A Stewart, Barbara L Lytle, Laine Thomas, Ganesa R Wegienka, Vanessa Jacoby, Michael P Diamond, Wanda K Nicholson, Raymond M Anchan, Sateria Venable, Kedra Wallace, Erica E Marsh, George L Maxwell, Bijan J Borah, William H Catherino, Evan R Myers
OBJECTIVE: To design and establish a uterine fibroid (UF) registry based in the United States (US) to provide comparative effectiveness data regarding UF treatment. STUDY DESIGN: We report here the design and initial recruitment for the Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF) registry (Clinicaltrials.gov, NCT02260752), funded by the Agency for Healthcare Research and Quality (AHRQ) in collaboration with the-Patient-Centered Outcomes Research Institute (PCORI)...
May 8, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29747655/microrna-21a-5p-overexpression-impacts-mediators-of-extracellular-matrix-formation-in-uterine-leiomyoma
#9
Eden R Cardozo, Rosemary Foster, Anatte E Karmon, Amy E Lee, Leah W Gatune, Bo R Rueda, Aaron K Styer
BACKGROUND: MicroRNAs (MiR) may promote fibroid development via altered expression of genes involved in cell proliferation and ECM formation, and evidence supports aberrant expression of MicroRNA (MiR) 21a-5p in fibroids. The purpose of this study was to investigate the functional significance of MiR 21a-5p overexpression in the pathobiology of leiomyomata (fibroids). METHODS: A basic science experimental design using immortalized fibroid and myometrial cell lines derived from patient-matched specimens was used...
May 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29743541/association-of-bet1l-and-tnrc6b-with-uterine-leiomyoma-risk-and-its-relevant-clinical-features-in-han-chinese-population
#10
Bailing Liu, Tao Wang, Jue Jiang, Miao Li, Wenqi Ma, Haibin Wu, Qi Zhou
Previous studies have shown that uterine leiomyomas (UL) are benign tumours with contributions from environmental and genetic factors. We aimed to replicate two initial significant genetic factors, TNRC6B and BET1L, in a Han Chinese population. A total of 2,055 study subjects were recruited, and 55 SNPs mapped to TNRC6B and BET1L were selected and genotyped in samples from these subjects. Genetic associations were analysed at both the single marker and haplotype levels. Associations between targeted SNPs and relevant clinical features of UL were analysed in case only samples...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742599/the-detection-of-uterine-leiomyoma-fibroid-calcifications-on-18f-naf-pet-ct
#11
Abdullah Al-Zaghal, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
Uterine leiomyomas (fibroids) are the most common type of uterine neoplasms in premenopausal women. Leiomyomas are estrogen dependent and tend to atrophy and shrink in size after menopause. Dystrophic calcification, cystic changes, and necrosis are among the changes that indicate uterine fibroid involution. We are presenting a calcified uterine leiomyoma in a 61-year-old woman as incidentally detected on F-NaF PET/CT scanning. Many previous publications have reported the accumulation of F-NaF in soft tissue calcifications; these findings further set new directions in the evaluation of the metabolic activity of macrocalcification and microcalcification using molecular imaging probes...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29742071/application-of-a-baseball-suture-technique-in-uterine-myomectomy-following-laparoscopic-enucleation-of-uterine-leiomyoma-fibroid
#12
Lingling Xie, Yunyun Liu, Dongyan Wang, Changhao Liu, Hui Zhou, Zhongqiu Lin, Huaiwu Lu
BACKGROUND The aim of this study was to evaluate the safety and efficacy of a 'baseball' suture technique for uterine myomectomy incision closure in laparoscopic surgical enucleation of uterine leiomyoma (fibroid). MATERIAL AND METHODS The study included 20 patients who underwent laparoscopic myomectomy with a 'baseball' suture technique, compared with 20 patients who underwent laparoscopic myomectomy with a standard suture method. Clinical characteristics, perioperative and follow-up data were compared between the two groups...
May 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29735316/use-of-contrast-enhanced-ultrasound-in-the-assessment-of-uterine-fibroids-a-feasibility-study
#13
Barbara Stoelinga, Anniek M C Dooper, Lynda J M Juffermans, Arnoud W Postema, Hessel Wijkstra, Hans A M Brölmann, Judith A F Huirne
Contrast-enhanced ultrasound (CEUS) is an innovative ultrasound technique capable of visualizing both the macro- and microvasculature of tissues. In this prospective pilot study, we evaluated the feasibility of using CEUS to visualize the microvasculature of uterine fibroids and compared CEUS with conventional ultrasound. Four women with fibroids underwent gray-scale ultrasound, sonoelastography and power/color Doppler scans followed by CEUS examination. Analysis of CEUS images revealed initial perfusion of the peripheral rim, that is, a pseudo-capsule, followed by enhancement of the entire lesion through vessels traveling from the exterior to the interior of the fibroid...
May 4, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29730954/proteomic-analysis-identifies-tenascin-c-expression-is-upregulated-in-uterine-fibroids
#14
M Fairuz B Jamaluddin, Prathima B Nagendra, Pravin Nahar, Christopher Oldmeadow, Pradeep S Tanwar
Uterine leiomyomas (fibroids) are the most common gynecological tumors, which are enriched in the extracellular matrix (ECM). Fibroids are leading cause of abnormal uterine bleeding and hysterectomy. One of the major questions yet to be answered is the overproduction of specific ECM components in human uterine fibroids, particularly in relation to mutations in the driver gene mediator complex subunit 12 ( MED12). Surgical specimens from 14 patients with uterine leiomyoma having fibroids and corresponding adjacent normal myometrium (ANM) were utilized to analyze genetic and proteomic expression patterns in the tissue samples...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29724419/acr-appropriateness-criteria-%C3%A2-radiologic-management-of-uterine-leiomyomas
#15
M-Grace Knuttinen, Gregory Stark, Eric J Hohenwalter, Linda D Bradley, Aaron R Braun, Matthew G Gipson, Charles Y Kim, Jason W Pinchot, Matthew J Scheidt, David M Sella, Clifford R Weiss, Jonathan M Lorenz
Uterine fibroids, also known as leiomyomas, are the most common benign tumor in women of reproductive age. When symptomatic, these patients can present with bleeding and/or bulk-related symptoms. Treatment options for symptomatic uterine leiomyomas include medical management, minimally invasive treatment such as uterine artery embolization, and surgical options, such as myomectomy. It is important to understand the role of these treatment options in various clinical scenarios so that appropriate consultation is performed...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29718788/vilaprisan-for-treating-uterine-fibroids
#16
Gian Benedetto Melis, Manuela Neri, Bruno Piras, Anna Maria Paoletti, Silvia Ajossa, Monica Pilloni, Maria Francesca Marotto, Valentina Corda, Alessandra Saba, Elena Giancane, Valerio Mais
Introduction The medical strategy to antagonize myoma size and related-symptoms is to reduce estrogen and progesterone activity on myomas. This can be obtained with the GnRH agonist (GnRHa) or with compounds that antagonize progesterone stimulatory activity on myomas. Selective progesterone receptor modulators (SPRMs) bind progesterone receptor (PR), leading to both agonist and antagonist effects. The result of SPRMs's action is tissue-specific and it depends on the particular affinity and strength of each SPRM...
May 2, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29706284/ulipristal-acetate-for-the-management-of-large-uterine-fibroids-associated-with-heavy-bleeding-a-review
#17
REVIEW
Jacques Donnez, Guillaume E Courtoy, Olivier Donnez, Marie-Madeleine Dolmans
Ulipristal acetate (UPA), a selective progesterone receptor modulator (SPRM), offers new therapeutic options for the clinical management of large uterine fibroids associated with heavy menstrual bleeding or with other moderate or severe symptoms (bulk symptoms, pelvic pain, decreased quality of life). SPRM are synthetic compounds that exert an agonist or antagonist effect on target tissues by their binding to progesterone receptors. UPA reduces fibroid size, controls bleeding in a high percentage of women and significantly improves quality of life...
April 21, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29688260/endocrine-disruptor-exposure-during-development-increases-incidence-of-uterine-fibroids-by-altering-dna-repair-in-myometrial-stem-cells
#18
Lauren Prusinski Fernung, Qiwei Yang, Daitoku Sakamuro, Alpana Kumari, Aymara Mas, Ayman Al-Hendy
Despite the major negative impact uterine fibroids (UFs) have on female reproductive health, little is known about early events that initiate development of these tumors. Somatic fibroid-causing mutations in MED12, the most frequent genetic alterations in UFs (up to 85% of tumors), are implicated in transforming normal myometrial stem cells (MSCs) into tumor-forming cells, though the underlying mechanism(s) leading to these mutations remains unknown. It is well-accepted that defective DNA repair increases the risk of acquiring tumor-driving mutations, though defects in DNA repair have not been explored in UF tumorigenesis...
April 24, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29670382/clinical-outcomes-and-health-care-utilization-pre-and-post-laparoscopic-radiofrequency-ablation-of-symptomatic-fibroids-and-laparoscopic-myomectomy-a-randomized-trial-of-uterine-sparing-techniques-trust-in-canada
#19
Darrien D Rattray, Laura Weins, Lexy C Regush, James M Bowen, Daria O'Reilly, John A Thiel
Objective: The objective of this study was to compare laparoscopic ultrasound-guided radiofrequency ablation of fibroids (Lap-RFA) and laparoscopic myomectomy in terms of 1) health care utilization and 2) serious complication rates. The secondary objectives were comparison of subject responses to validated symptom and quality-of-life questionnaires. We hypothesized that Lap-RFA health care utilization and clinical outcomes would not be worse than those of laparoscopic myomectomy in the aggregate...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29668367/which-patients-with-cervical-squamous-cell-carcinoma-might-benefit-from-neoadjuvant-chemotherapy
#20
Omar Mahmoud, Mark H Einstein
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
April 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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