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Uterine fibroids

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https://www.readbyqxmd.com/read/28715450/african-genetic-ancestry-interacts-with-body-mass-index-to-modify-risk-for-uterine-fibroids
#1
Ayush Giri, Todd L Edwards, Katherine E Hartmann, Eric S Torstenson, Melissa Wellons, Pamela J Schreiner, Digna R Velez Edwards
Race, specifically African ancestry, and obesity are important risk factors for uterine fibroids, and likely interact to provide the right conditions for fibroid growth. However, existing studies largely focus on the main-effects rather than their interaction. Here, we firstly provide evidence for interaction between categories of body mass index (BMI) and reported-race in relation to uterine fibroids. We then investigate whether the association between inferred local European ancestry and fibroid risk is modified by BMI in African American (AA) women in the Vanderbilt University Medical Center bio-repository (BioVU) (539 cases and 794 controls) and the Coronary Artery Risk Development in Young Adults study (CARDIA, 264 cases and 173 controls)...
July 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28715088/clinical-limitations-of-the-international-federation-of-gynecology-and-obstetrics-figo-staging-of-uterine-fibroids
#2
Shannon K Laughlin-Tommaso, Gina K Hesley, Matthew R Hopkins, Kathleen R Brandt, Yunxiao Zhu, Elizabeth A Stewart
OBJECTIVE: To determine the reproducibility of classifying uterine fibroid using the 2011 International Federation of Gynecology and Obstetrics (FIGO) staging system. METHODS: The present retrospective cohort study included patients presenting for the treatment of symptomatic uterine fibroids at the Gynecology Fibroid Clinic at Mayo Clinic, Rochester, USA, between April 1, 2013 and April 1, 2014. Magnetic resonance imaging of fibroid uteri was performed and the images were independently reviewed by two academic gynecologists and two radiologists specializing in fibroid care...
July 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28696085/does-fibroids-surgery-by-endoscopy-or-laparotomy-represent-a-malignancy-threat
#3
Liselotte Mettler, Khulkar Abdusattarova, Ibrahim Alkatout
BACKGROUND: 1) to estimate the incidence of unsuspected uterine sarcoma in patients after myomectomies and hysterectomies for benign uterine fibroids. 2) to assessed the incidence of uterine sarcomas among patient who had uterine fibroids or a suspicion of uterine sarcoma before undergoing the surgical procedures. METHODS: Retrospective study in single center university hospital. Patient 's records with uterine fibroids and uterine sarcoma from 2003 to 2015 collected...
July 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28692605/examining-the-relationship-between-symptomatic-burden-and-self-reported-productivity-losses-among-patients-with-uterine-fibroids-in-the-united-states
#4
Ahmed M Soliman, Savita Bakhshi Anand, Karin S Coyne, Jane Castelli-Haley, Michael Snabes, Charlotte D Owens
OBJECTIVE: To evaluate the impact of uterine fibroid symptoms on employment and household productivity. METHODS: An online survey of US women between 18 and 54 was conducted. Productivity was assessed using the health related productivity questionnaire (HRPQ). Descriptive statistics and logistic multivariable regressions examined the relationship between uterine fibroids (UF) symptom experience and employment and household productivity. RESULTS: Of 1365 eligible women, 873 (64...
July 7, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28691348/rare-complication-of-fibroids-in-pregnancy-spontaneous-fibroid-rupture
#5
Alim Swarray-Deen, Shirley A Mensah-Brown, Jerry Coleman
Uterine fibroids in pregnancy present with numerous complications. However, spontaneous rupture is a rare and potentially life-threatening event. We report a case of a 43-year-old multiparous woman who presented with hypovolemic shock secondary to a ruptured uterine fibroid 2 days after a spontaneous vaginal delivery. Emergency laparotomy confirmed massive intra-abdominal hemorrhage from the ruptured capsule of a 10-cm subserosal fibroid. A myomectomy was performed. Her postoperative recovery period was uneventful...
July 10, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28676450/real-world-data-of-197-patients-treated-with-ulipristal-acetate-for-uterine-fibroids-premya-study-french-population-main-outcomes
#6
H Fernandez, P Descamps, M Koskas, P Lopès, J L Brun, E Darai, A Agostini
OBJECTIVES: To characterize and describe treatment with ulipristal acetate (UPA) in a preoperative setting and to evaluate the safety, effectiveness, and Health Related Quality of Life (HRQoL) outcomes in a French population treated according to standard clinical practice. MATERIALS AND METHODS: Multicentre, prospective, non-interventional study (PREMYA) of patients diagnosed with moderate to severe symptoms of uterine fibroids and undergoing a preoperative treatment with UPA 5mg (Esmya(®))...
July 1, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28676073/one-year-symptom-severity-and-health-related-quality-of-life-changes-among-black-african-patients-undergoing-uterine-fibroid-embolisation
#7
Charles Mariara, Timona Obura, Nigel Hacking, William Stones
BACKGROUND: The main aim in the treatment of symptomatic fibroids by various modalities including uterine fibroid embolisation (UFE) is to alleviate symptoms and ultimately improve the quality of life. The efficacy of this modality of treatment in Black African women with significant fibroid burden and large uterine volumes is not clear. The main objective of the study was to examine potential changes in symptom severity among Black African patients 1 year following UFE for symptomatic uterine fibroids in a resource-constrained setting, rated using a validated questionnaire (UFS-QOL)...
July 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28670051/ineffectiveness-of-magnetic-resonance-imaging-enhancement-to-predict-fibroid-volume-reduction-after-uterine-artery-embolization
#8
Ginny Bao, Lizbeth Hu, Hearns W Charles, Amy R Deipolyi
Fibroid nonenhancement is considered a relative contraindication to uterine artery embolization (UAE) for symptomatic fibroids. This retrospective study assessed the impact of UAE on nonenhancing fibroids to determine imaging predictors of fibroid shrinkage. All women who underwent UAE for symptomatic fibroids between May 2009 and July 2014 and had follow-up magnetic resonance imaging 6 months after UAE were included. There were 59 fibroids (5 nonenhancing, 54 enhancing) among 18 women aged 40 to 53 (mean 46) years...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28662989/radiofrequency-thermal-ablation-for-uterine-fibroids-long-term-clinical-outcomes-and-reinterventions
#9
Helene Iversen, Margit Dueholm
STUDY OBJECTIVE: To assess the long-term efficacy and rate of reintervention after ultrasound-guided radiofrequency thermal ablation (RFA) for uterine fibroids. DESIGN: A retrospective follow-up, cohort study (Canadian Task Force Classification II-2) SETTING: University hospitals and private clinics. PATIENTS: Between November 1, 2007 and February 26, 2010, 66 consecutive women underwent ultrasound-guided RFA. INTERVENTIONS: Patients underwent abdominal or vaginal ultrasound-guided RFA and were contacted for a long-term follow-up to complete the Uterine Fibroid Symptom and Quality of Life Score questionnaire (UFS-QOL) and optional ultrasound and examination...
June 26, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28659546/focused-ultrasound-treatment-present-and-future
#10
Keiichi Abe, Takaomi Taira
The discovery that ultrasound waves could be focused inside the skull and heated to high temperatures at a focal point goes back to 1944. However, because the skull causes the ultrasound waves to attenuate and scatter, it was believed that application of this technology would be difficult, and that it would be impossible to use this approach in the surgical treatment of intracranial diseases. Eventually, magnetic resonance image guided focused ultrasound (MRgFUS) surgery began being used to treat uterine fibroids, breast cancer and bone metastasis and locally confined prostate cancer...
June 28, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28653894/molecular-and-clinical-attributes-of-uterine-leiomyomas
#11
REVIEW
Dana Dvorská, Dušan Braný, Zuzana Danková, Erika Halašová, Jozef Višňovský
Uterine leiomyomas, also called uterine fibroids or myomas, represent one of the most common benign tumour types in women of a fertile age. Leiomyomas arise due to transformation of the layer of smooth muscle cells of corpus uteri - the myometrium. Despite frequent occurrence of this disease, the molecular mechanisms behind the origin and development of leiomyomas are still relatively unknown. Most predisposed are obese women and women of African origin. In more than half of cases, leiomyomas remain asymptomatic...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28652819/patient-reported-prevalence-and-symptomatic-burden-of-uterine-fibroids-among-women-in-the-united-states-findings-from-a-cross-sectional-survey-analysis
#12
Mahesh J Fuldeore, Ahmed M Soliman
PURPOSE: To estimate the prevalence of women diagnosed with uterine fibroids and the associated symptom burden in the US. PATIENTS AND METHODS: Responses of women aged 18-54 years, who completed an online survey, were analyzed. Data were weighted based on age, education, race, geographic region, income, and propensity score to derive national estimates of the prevalence of women diagnosed with uterine fibroids and associated symptom burden. Weighted means and percentages were reported...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28651276/white-paper-interventional-mri-current-status-and-potential-for-development-considering-economic-perspectives-part-1-general-application
#13
Jörg Barkhausen, Thomas Kahn, Gabriele A Krombach, Christiane K Kuhl, Joachim Lotz, David Maintz, Jens Ricke, Stefan O Schönberg, Thomas J Vogl, Frank K Wacker
Background MRI is attractive for the guiding and monitoring of interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure physiologic parameters like flow and cardiac function. Method The current status of interventional MRI for the clinical routine was analyzed. Results The effort needed for the development of MR-safe monitoring systems and instruments initially resulted in the application of interventional MRI only for procedures that could not be performed by other means...
July 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28649392/blood-cadmium-and-volume-of-uterine-fibroids-in-premenopausal-women
#14
Shinhee Ye, Hye Won Chung, Kyungah Jeong, Yeon-Ah Sung, Hyejin Lee, So Yun Park, Hyunjoo Kim, Eun-Hee Ha
BACKGROUND: A number of studies have found associations between heavy metals and uterine fibroids, but the results are inconsistent. Here, we conducted this research to demonstrate the relationships between blood heavy metal concentrations and uterine fibroid volume as well as the rate of uterine fibroid presence. METHODS: In a cross-sectional study, we collected data from 308 premenopausal women aged 30-49 years in Seoul; uterine fibroids are ascertained by past history of myomectomy and pelvic ultrasonography...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28638108/pregnancy-outcomes-in-nulliparous-women-after-ultrasound-ablation-of-uterine-fibroids-a-single-central-retrospective-study
#15
Jun Shu Li, Yong Wang, Jin Yun Chen, Wen Zhi Chen
To explore the impact of high-intensity focused ultrasound (HIFU) ablation of uterine fibroids in nulliparous women on subsequent pregnancy and delivery. A retrospective analysis was conducted of nulliparous women who received HIFU treatment at Chongqing Medical University, Chongqing,China, from January 1, 2010, to January 1, 2015. A total of 189 cases were enrolled, the median follow-up time was three years. Among them,there were 131 cases pregnancy with a total of 133 times,the pregnancy rate was 69.3% (131/189),and the spontaneous conception rate was 95...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28637238/chlamydia-trachomatis-seroprevalence-and-ultrasound-diagnosed-uterine-fibroids-in-a-large-population-of-young-african-american-women
#16
Kristen R Moore, Jennifer S Smith, Stephen R Cole, Dirk P Dittmer, Victor J Schoenbach, Donna D Baird
Reproductive tract infections have long been hypothesized to increase fibroid risk. Few studies have been conducted, even for the common infection, genital Chlamydia trachomatis (gCT), and only with self-reported gCT data. Our investigation used micro-immunofluorescence serology for gCT to characterize past exposure. We used cross-sectional enrollment data from a prospective fibroid study in the Detroit, Michigan area; ultrasound examinations systematically screened for fibroids. Participants were African-American women ages 23-34 (recruited 2010-2012)...
June 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28635407/ovarian-reserve-after-fibroid-embolization-in-premenopausal-women
#17
Panagiotis Tsikouras, Bachar Manav, Zacharoula Koukouli, Grigorios Trypsiannis, Georgios Galazios, Dimitrios Souftas, Vasileios Souftas
OBJECTIVE: To investigate the effect of uterine artery embolization (UAE) for fibroids on ovarian pool of premenopausal women. STUDY DESIGN: Prospective case control study. MATERIAL AND METHODS: One-hundred and twenty premenopausal women, aged between 40 and 50 years, who underwent UAE for symptomatic uterine fibroids and the same number of women, aged between 40 and 50 years, with symptomatic uterine fibroids, who were not offered treatment were recruited for this study...
February 24, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28616725/the-role-of-t1-perfusion-based-classification-in-magnetic-resonance-guided-high-intensity-focused-ultrasound-ablation-of-uterine-fibroids
#18
Bilgin Keserci, Nguyen Minh Duc
OBJECTIVE: To comparatively evaluate the role of magnetic resonance (MR) T1 perfusion-based time-signal intensity (SI) curves of fibroid tissue and the myometrium in classification of fibroids for predicting treatment outcomes of high-intensity focused ultrasound (HIFU) treatment. METHODS: The fibroids of 74 women who underwent MR-HIFU treatment were classified into group A (time-SI curve of fibroid lower than that of the myometrium) and group B (time-SI curve of fibroid equal to or higher than that of the myometrium)...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28609115/molecular-targets-of-dietary-phytochemicals-for-possible-prevention-and-therapy-of-uterine-fibroids-focus-on-fibrosis
#19
Md Soriful Islam, Most Mauluda Akhtar, James H Segars, Mario Castellucci, Pasquapina Ciarmela
Uterine fibroids (myomas or leiomyomas) are common benign tumors of reproductive aged women. Fibroids are clinically apparent in 20-50% of women, and cause abnormal uterine bleeding, abdominal pain and discomfort, pregnancy complications and infertility. Unfortunately, limited numbers of medical treatment are available but no effective preventive strategies exist. Moreover, the benefits of medical treatments are tempered by lack of efficacy or serious adverse side effects. Fibrosis has recently been recognized as a key pathological event in leiomyoma development and growth...
November 22, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28608747/spontaneous-pregnancy-with-a-live-birth-after-conventional-and-partial-uterine-fibroid-embolization
#20
João M Pisco, Marisa Duarte, Tiago Bilhim, Jorge Branco, Fernando Cirurgião, Marcela Forjaz, Lúcia Fernandes, José Pereira, Nuno Costa, Joana B M Pisco, António G Oliveira
Purpose To determine pregnancy rates after conventional and partial uterine fibroid embolization (UFE). Materials and Methods The study received institutional review board approval and all patients gave written informed consent. A retrospective analysis of data collected prospectively was performed between June 2004 and June 2014 in a cohort of 359 women (mean age, 35.9 years ± 4.8) with uterine fibroids and/or adenomyosis who were unable to conceive. The median follow-up period was 69 months (range, 6-126 months)...
June 13, 2017: Radiology
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