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https://www.readbyqxmd.com/read/29917327/middle-turbinate-manipulation-and-postoperative-sinus-obstruction-after-endoscopic-endonasal-skull-base-surgery
#1
Thomas J Willson, Nicholas R Rowan, Eric W Wang
BACKGROUND: Inadvertent lateralization of the middle turbinate (MT) after endoscopic sinus surgery (ESS) is cited as a common complication that results in both outflow tract obstruction and recurrent symptoms. In endoscopic endonasal skull-base surgery, the MT is frequently lateralized during the parasagittal approach. Little is known about whether this strategy has unintended consequences on the adjacent paranasal sinuses. Intentional lateralization vs surgical resection of the MT were compared for radiographic evidence of sinus obstruction in this patient population...
June 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29917325/introduction-of-the-colorectal-cancer-screening-program-results-from-a-single-centre-study
#2
Nina C A Vermeer, Renu R Bahadoer, Esther Bastiaannet, Fabian A Holman, Elma Meershoek-Klein Kranenbarg, Gerrit-Jan Liefers, Cornelis J H van de Velde, Koen C M J Peeters
AIM: In 2014, a national colorectal cancer (CRC) screening program was launched in the Netherlands. It is difficult to assess for the individual CRC patient whether the oncological benefits of surgery will outweigh the morbidity of the procedure, especially in early lesions. This study compares patient and tumour characteristics between screen-detected and non-screen-detected patients. Secondly, we present an overview of treatment options and clinical dilemmas when treating patients with early stage colorectal disease...
June 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29917280/protective-effects-of-cinnamon-bark-extract-against-ischemia-reperfusion-injury-and-arrhythmias-in-rat
#3
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29917270/lagloc-a-new-surgical-technique-for-locking-plate-systems
#4
Miguel Triana, Boyko Gueorguiev, Christoph Sommer, Karl Stoffel, Yash Agarwal, Ivan Zderic, Tobias Helfen, James C Krieg, Fabian Krause, Matthias Knobe, R Geoff Richards, Mark Lenz
Treatment of oblique and spiral fractures remains challenging. The aim of this study was to introduce and investigate the new LagLoc technique for locked plating with generation of interfragmentary compression, combining the advantages of lag-screw and locking-head-screw techniques. Oblique fracture was simulated in artificial diaphyseal bones, assigned to three groups for plating with a 7-hole locking compression plate. Group I was plated with three locking screws in holes 1, 4 and 7. The central screw crossed the fracture line...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29917257/the-long-non-coding-rnas-mhrt-fendrr-and-carmen-their-expression-levels-in-peripheral-blood-mononuclear-cells-in-patients-with-essential-hypertension-and-their-relation-to-heart-hypertrophy
#5
Joanna E Kontaraki, Maria E Marketou, George E Kochiadakis, Spyros Maragkoudakis, John Konstantinou, Panos E Vardas, Fragiskos I Parthenakis
Long non-coding RNAs (lncRNAs) participate in the modulation of cardiac hypertrophy and they represent potential therapeutic targets in cardiovascular disease. We investigated the expression profiles of selected lncRNAs in peripheral blood mononuclear cells of patients with essential hypertension in relation to left ventricular hypertrophy. We assessed the expression levels of the lncRNAs MHRT, FENDRR and CARMEN using real-time reverse transcription polymerase chain reaction. Hypertensive patients showed significantly higher MHRT, FENDRR and CARMEN expression levels compared with healthy controls...
June 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29917228/title-reduced-blood-volume-decreases-cerebral-blood-flow-in-preterm-piglets
#6
Yvonne A Eiby, Nicole Y Shrimpton, Ian M R Wright, Eugenie R Lumbers, Paul B Colditz, Greg J Duncombe, Barbara E Lingwood
Preterm infants often have impaired cardiovascular function that may contribute to poor neurodevelopmental outcomes. The study aimed to determine the effects of reduced blood volume on cardiovascular function, including cerebral blood flow in preterm and term piglets. In preterm (97/115d) and term piglets, up to 10% of the estimated blood volume was removed. Removal of blood was ceased if MAP dropped below 20 mmHg. Heart rate, cardiac contractility and relaxation, cardiac output, mean arterial pressure (MAP), and cerebral blood flow were measured at baseline and again after blood volume reduction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917219/correlation-between-hsd17b4-expression-in-rat-liver-cancer-tissues-and-inflammation-or-proliferation
#7
L-C Pan, H-Y Xiao, W-J Yin, Z Lin
OBJECTIVE: Pathogenesis and progression of liver cancer are correlated with inflammatory response and estrogen level. 17β-estradiol dehydrogenase IV (HSD17B4) is highly expressed in human liver cancer tissues. HSD17B4 participates in liver cancer cell proliferation via suppressing estradiol (E2) activity. This study generated a rat liver cancer model, on which the correlations between HSD17B4 and tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), proliferating cell nucleus antigen (PCNA) expression were analyzed...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917217/oral-administration-of-a-curcumin-phospholipid-formulation-meriva%C3%A2-for-treatment-of-chronic-diabetic-macular-edema-a-pilot-study
#8
F Mazzolani, S Togni, L Giacomelli, R Eggenhoffner, F Franceschi
OBJECTIVE: The purpose of this open-label study was to investigate the effect of a curcumin-phospholipid lecithin formulation (Meriva®) on visual acuity and optical coherence tomography (OCT) retinal thickness in patients with chronic diabetic macular edema. PATIENTS AND METHODS: Curcumin-phospholipid lecithin formulation (Meriva®, Indena S.p.A, Milan, Italy) was administered as tablets (Norflo®, Eye Pharma, Genoa, Italy) twice a day. Visual acuity and macular edema as measured by OCT before and after curcumin-phospholipid formulation treatment were assessed...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917210/bioinformatics-analysis-of-common-differential-genes-of-coronary-artery-disease-and-ischemic-cardiomyopathy
#9
G-M Li, C-L Zhang, R-P Rui, B Sun, W Guo
OBJECTIVE: This paper aims at screening the common differential genes of coronary atherosclerotic heart disease (CAD) and ischemic cardiomyopathy (ICM), and to conduct pathway analysis and protein-protein interaction (PPI) network analysis for the differential genes. MATERIALS AND METHODS: The CAD and ICM datasets were collected from the Gene Expression Omnibus (GEO) database for human tumors to extract data components of peripheral blood RNA of patients and normal people in GSE71226 and GSE9128 chips; "limma" package of "R" software was used to screen the differential genes, and "pheatmap" package was applied to construct heat maps for the differential genes; Cytoscape, Database for Annotation, Visualization and Integration Discovery (DAVID) and String platforms were utilized for PPI network analysis, Genome Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the selected differential genes...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917208/type-i-cardiorenal-syndrome-in-patients-with-acutely-decompensated-heart-failure-the-importance-of-new-renal-biomarkers
#10
A Atici, S Emet, R Cakmak, G Yuruyen, A Alibeyoglu, M Akarsu, Y Arman, M Kose, E Ozgun, M Ozcan, O Altun, I Onur, T Tukek
OBJECTIVE: Type 1 cardiorenal syndrome (CRS) is an acute renal failure in patients with acute decompensated heart failure with an incidence of 24% to 45%. The aim of our study was to investigate the significance of new renal biomarkers to predict type 1 CRS. PATIENTS AND METHODS: The study included 111 patients with acute decompensated heart failure diagnosed at the Istanbul Medical Faculty Emergency Department between 2014 and 2016, and 24 healthy volunteers. All urine samples were stored at -80°C after centrifugation...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917201/a-study-on-correlations-of-procalcitonin-and-interleukin-6-with-viral-meningitis
#11
D-B Liu, H-P Zhang, K Yu, Q-B Lu, Z-F Zhu
OBJECTIVE: To study the change rules of inflammatory factors in cerebrospinal fluid (CSF) and serum of patients with viral meningitis. PATIENTS AND METHODS: 742 patients with suspected viral meningitis admitted to Department of Neurosurgery in our hospital from August 2012 to May 2016 were selected as research objects and retrospectively analyzed. 536 patients were diagnosed with viral meningitis by CSF with the lumbar puncture and brain computed tomography (CT), while the other 206 patients were diagnosed with non-infectious nervous system disease, as the control group...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917200/analysis-the-effect-of-hyperbaric-oxygen-preconditioning-on-neuronal-apoptosis-ca2-concentration-and-caspases-expression-after-spinal-cord-injury-in-rats
#12
J-Y Pan, R-X Cai, Y Chen, Y Li, W-W Lin, J Wu, X-D Wang
OBJECTIVE: To investigate the effects of hyperbaric oxygen preconditioning (HBO-PC) on neuronal apoptosis, Ca2+ concentration, and Caspases expression after spinal cord injury (SCI) in rats. MATERIALS AND METHODS: A total of 36 rats were randomly divided into control group (CON group), hyperbaric oxygen preconditioning group (HBO-PC group) and spinal cord injury group (SCI group), with 12 rats in each group. Rats in group HBO-PC were given HBO-PC intervention before modeling...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917198/an-analysis-of-cognitive-functioning-of-children-and-youth-with-type-1-diabetes-t1dm-in-the-context-of-glycemic-control
#13
M Stanisławska-Kubiak, E Mojs, R W Wójciak, B Piasecki, M Matecka, J Sokalski, P Kopczyński, P Fichna
OBJECTIVE: The aim of the study was to evaluate the cognitive functioning of children and youth with type 1 diabetes (T1DM). PATIENTS AND METHODS: The study included 68 children with type 1 diabetes, aged 6-17 years, divided into 3 groups according to the level of glycated hemoglobin (HbA1c): group 1: HbA1c ≤ 6.0-7.5%; group 2: HbA1c 7.6-8.5%; group 3: HbA1c over 8.6%. Wechsler's intelligence scale (WISC-R), the Trail of 10 words and Brickenkamp's and Zillmer's d2 Test of Attention were used to assess cognitive functioning...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917196/bml-111-inhibits-the-inflammatory-response-and-apoptosis-of-renal-tissue-in-rats-with-hemorrhagic-shock-by-inhibiting-the-mapk-pathway
#14
S-Y Chang, R-Q Sun, M Feng, Y-X Li, H-L Wang, Y-M Xu
OBJECTIVE: The effect of lipoxin receptor agonist BML-111 on acute kidney injury and AKI in rats with hemorrhagic shock (HS) and its mechanism were investigated. MATERIALS AND METHODS: A model of hemorrhagic shock in Sprague-Dawley (SD) rats was established, and recovered after 30 min of shock. 1 mg/kg BML-111 was intraperitoneally injected at the beginning of resuscitation in group BML-111. The concentration of serum creatinine, serum KIM-1 content, NGAL and inflammatory factors were detected...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917189/expressions-and-correlation-analysis-of-hif-1%C3%AE-survivin-and-vegf-in-patients-with-hepatocarcinoma
#15
Q-G Tian, Y-T Wu, Y Liu, J Zhang, Z-Q Song, W-F Gao, T-K Guo, C-H He, F-R Dai
OBJECTIVE: To investigate the expressions of HIF-1α, surviving, and VEGF in patients with hepatocarcinoma as well as the correlation analysis among them. PATIENTS AND METHODS: 65 patients, who were admitted to our hospital and diagnosed as hepatocarcinoma from January 2014 to October 2015, were selected as hepatocarcinoma group, while 50 healthy cases that do not have hepatocarcinoma were selected as normal control group. The expression levels of HIF-1α, surviving, and VEGF in hepatocarcinoma tissues of hepatocarcinoma group and normal liver tissues of control group were detected by immunohistochemical (SP) staining method; then, the correlation among them was explored...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917119/novel-common-genetic-susceptibility-loci-for-colorectal-cancer
#16
Stephanie L Schmit, Christopher K Edlund, Fredrick R Schumacher, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Chenxu Qu, Marilena Melas, David J Van Den Berg, Hansong Wang, Stephanie Tring, Sarah J Plummer, Demetrius Albanes, M Henar Alonso, Christopher I Amos, Kristen Anton, Aaron K Aragaki, Volker Arndt, Elizabeth L Barry, Sonja I Berndt, Stéphane Bezieau, Stephanie Bien, Amanda Bloomer, Juergen Boehm, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Daniel D Buchanan, Katja Butterbach, Bette J Caan, Peter T Campbell, Christopher S Carlson, Jose E Castelao, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Iona Cheng, Ya-Wen Cheng, Lee Soo Chin, James M Church, Timothy Church, Gerhard A Coetzee, Michelle Cotterchio, Marcia Cruz Correa, Keith R Curtis, David Duggan, Douglas F Easton, Dallas English, Edith J M Feskens, Rocky Fischer, Liesel M FitzGerald, Barbara K Fortini, Lars G Fritsche, Charles S Fuchs, Manuela Gago-Dominguez, Manish Gala, Steven J Gallinger, W James Gauderman, Graham G Giles, Edward L Giovannucci, Stephanie M Gogarten, Clicerio Gonzalez-Villalpando, Elena M Gonzalez-Villalpando, William M Grady, Joel K Greenson, Andrea Gsur, Marc Gunter, Christopher A Haiman, Jochen Hampe, Sophia Harlid, John F Harju, Richard B Hayes, Philipp Hofer, Michael Hoffmeister, John L Hopper, Shu-Chen Huang, Jose Maria Huerta, Thomas J Hudson, David J Hunter, Gregory E Idos, Motoki Iwasaki, Rebecca D Jackson, Eric J Jacobs, Sun Ha Jee, Mark A Jenkins, Wei-Hua Jia, Shuo Jiao, Amit D Joshi, Laurence N Kolonel, Suminori Kono, Charles Kooperberg, Vittorio Krogh, Tilman Kuehn, Sébastien Küry, Andrea LaCroix, Cecelia A Laurie, Flavio Lejbkowicz, Mathieu Lemire, Heinz-Josef Lenz, David Levine, Christopher I Li, Li Li, Wolfgang Lieb, Yi Lin, Noralane M Lindor, Yun-Ru Liu, Fotios Loupakis, Yingchang Lu, Frank Luh, Jing Ma, Christoph Mancao, Frank J Manion, Sanford D Markowitz, Vicente Martin, Koichi Matsuda, Keitaro Matsuo, Kevin J McDonnell, Caroline E McNeil, Roger Milne, Antonio J Molina, Bhramar Mukherjee, Neil Murphy, Polly A Newcomb, Kenneth Offit, Hanane Omichessan, Domenico Palli, Jesus P Paredes Cotoré, Julyann Pérez-Mayoral, Paul D Pharoah, John D Potter, Conghui Qu, Leon Raskin, Gad Rennert, Hedy S Rennert, Bridget M Riggs, Clemens Schafmayer, Robert E Schoen, Thomas A Sellers, Daniela Seminara, Gianluca Severi, Wei Shi, David Shibata, Xiao-Ou Shu, Erin M Siegel, Martha L Slattery, Melissa Southey, Zsofia K Stadler, Mariana C Stern, Sebastian Stintzing, Darin Taverna, Stephen N Thibodeau, Duncan C Thomas, Antonia Trichopoulou, Shoichiro Tsugane, Cornelia M Ulrich, Franzel J B van Duijnhoven, Bethany van Guelpan, Joseph Vijai, Jarmo Virtamo, Stephanie J Weinstein, Emily White, Aung Ko Win, Alicja Wolk, Michael Woods, Anna H Wu, Kana Wu, Yong-Bing Xiang, Yun Yen, Brent W Zanke, Yi-Xin Zeng, Ben Zhang, Niha Zubair, Sun-Seog Kweon, Jane C Figueiredo, Wei Zheng, Loic Le Marchand, Annika Lindblom, Victor Moreno, Ulrike Peters, Graham Casey, Li Hsu, David V Conti, Stephen B Gruber
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk. Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315)...
June 16, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29917116/pediatric-supratentorial-ependymoma-surgical-clinical-and-molecular-analysis
#17
Jock C Lillard, Garrett T Venable, Nickalus R Khan, Ruth G Tatevossian, James Dalton, Brandy N Vaughn, Paul Klimo
BACKGROUND: Pediatric supratentorial ependymomas (SEs) have distinct molecular and behavioral differences from their infratentorial counterparts. OBJECTIVE: To present our experience with pediatric SEs over a 24-yr period. METHODS: Clinical, operative, and radiographic information was abstracted retrospectively. Our primary outcomes were progression-free survival (PFS) and overall survival (OS). Detection of C11orf95-RELA rearrangement was performed using interphase fluorescence in situ hybridization (iFISH)...
June 16, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29917093/noninvasive-thermal-evaluation-of-ventriculoperitoneal-shunt-patency-and-cerebrospinal-fluid-flow-using-a-flow-enhancing-device
#18
Mustafa Q Hameed, David Zurakowski, Mark R Proctor, Scellig S D Stone, Benjamin C Warf, Edward R Smith, Liliana C Goumnerova, Marek Swoboda, Tomer Anor, Joseph R Madsen
BACKGROUND: While a noninvasive flow determination would be desirable in the diagnosis of cerebrospinal fluid shunt malfunction, existing studies have not yet defined a role for thermal flow detection. OBJECTIVE: To evaluate a revised test protocol using a micropumper designed to transiently enhance flow during thermal testing to determine whether thermal detection of flow is associated with progression to shunt revision surgery. METHODS: Eighty-two unique tests were performed in 71 shunts...
June 16, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29917083/sex-differences-in-reproductive-hormones-during-mini-puberty-in-infants-with-normal-and-disordered-sex-development
#19
T H Johannsen, K M Main, M L Ljubicic, T K Jensen, H R Andersen, M S Andersen, J H Petersen, A-M Andersson, A Juul
CONTEXT: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exists on sex-specific reference ranges for these hormones during early life. OBJECTIVE: To evaluate sex-differences in reproductive hormone concentrations in serum from healthy infants in order to define sex-specific cut-off values and to apply these in infants with DSD...
June 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29917078/reported-changes-in-oral-health-related-quality-of-life-in-children-and-adolescents-before-during-and-after-orthodontic-treatment-a-longitudinal-study
#20
Katrien Jaeken, Maria Cadenas de Llano-Pérula, Jurgen Lemiere, Anna Verdonck, Steffen Fieuws, Guy Willems
Objectives: To investigate the changes in oral health-related quality of life (OHRQoL) before, during, and after orthodontic treatment, determine the relationship with the original treatment need and evaluate the influence of self-esteem (SE). Materials and methods: OHRQoL questionnaires were used in an ongoing observational prospective cohort study at baseline (T0), 1 year after start (T1), and 1 month after the end of active orthodontic treatment (T2). Participants were 11-16-year-old at baseline and 215 complete cases were obtained from a total of 498...
June 18, 2018: European Journal of Orthodontics
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