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https://www.readbyqxmd.com/read/29475206/association-between-forefoot-bone-length-and-performance-in-male-endurance-runners
#1
Hiromasa Ueno, Tadashi Suga, Kenji Takao, Takahiro Tanaka, Jun Misaki, Yuto Miyake, Akinori Nagano, Tadao Isaka
Recently, we reported that the forefoot bones were longer in sprinters than in non-sprinters, and that longer forefoot bones correlated with higher sprint performance in sprinters. To further understand the superiority of long forefoot bones in athletic performance, we examined whether forefoot bone length was associated with running performance in endurance runners. The length of the forefoot bones of the big and second toes were measured using magnetic resonance imaging in 45 male well-trained endurance runners and 45 male untrained subjects...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475205/the-pituitary-thyroid-axis-and-prolactin-secretion-in-hemodialysis-patients-in-two-endemic-regions-of-eastern-germany
#2
Franz Maximilian Rasche, Ronny Rettig, Thomas Frese, Wilma Gertrud Rasche, Filip Barinka, Guenter Roesl, Frieder Keller, Tom H Lindner, Jochen G Schneider, Joachim Beige, Thomas Ebert, Stephan Schiekofer
INTRODUCTION: Endocrine disorders of the pituitary axes are frequent in patients with hemodialysis (CKD5D). The aim of this multicenter study (Leipzig (L), Quedlinburg and Blankenburg in the Harz region (Hz)) in CKD5D patients was to evaluate influences of CKD5D related factors, morphological and biochemical parameters, and serum iodine and prolactin concentrations on the pituitary-thyroid axis. PATIENTS AND METHODS: 170 patients (L n=58; Hz n=112) were included in this prospective, non-interventional, cross-sectional study...
February 23, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29475116/sources-and-fate-of-polycyclic-aromatic-compounds-pahs-oxygenated-pahs-and-azaarenes-in-forest-soil-profiles-opposite-of-an-aluminium-plant
#3
Benjamin A Musa Bandowe, Moritz Bigalke, Jozef Kobza, Wolfgang Wilcke
Little is known about oxygenated polycyclic aromatic hydrocarbons (OPAHs) and azaarenes (AZAs) in forest soils. We sampled all horizons of forest soils from five locations at increasing distances from an Al plant in Slovakia, and determined their polycyclic aromatic compound (PACs) concentrations. The ∑29PAHs concentrations were highest in the Oa and lowest in the Oi horizon, while the ∑14OPAHs and ∑4AZAs concentrations did not show a consistent vertical distribution among the organic horizons. The concentration ratios of PAHs and OPAHs between deeper O horizons and their overlying horizon (enrichment factors) were positively correlated with the octanol-water partition coefficients (KOW ) at several locations...
February 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29475081/evaluation-of-neurosensory-disturbances-of-the-inferior-alveolar-nerve-after-intraoral-verticosagittal-ramus-osteotomy
#4
L A R Righesso, L F Gil, D S M C Pantoja, C Marin, R Granato, J N Gil
PURPOSE: To assess the incidence of Neurosensory Disturbances (NSD) of the Inferior Alveolar Nerve (IAN) after Intraoral Verticosagittal Ramus Osteotomy (IVSRO). MATERIALS AND METHODS: The sensibility of the chin and lower lip of ten consecutive patients undergoing IVSRO was assessed. Evaluations were performed at 7 days preoperatively, 7 days, one month and six months postoperatively. The chin was divided into four quadrants, which were tested separately. The tests used were: two-point discrimination (2-P), brush stroke direction discrimination (BSD) and thermal stimuli (TH)...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29475075/nesfatin-1-and-visfatin-expression-is-associated-with-reduced-atherosclerotic-disease-risk-in-patients-with-rheumatoid-arthritis
#5
Chanel Robinson, Linda Tsang, Ahmed Solomon, Angela J Woodiwiss, Sule Gunter, Mervyn Mer, Hon-Chun Hsu, Monica Gomes, Gavin R Norton, Aletta M E Millen, Patrick H Dessein
Nesfatin is an anti-inflammatory molecule that reduces atherosclerotic cardiovascular risk. By contrast, visfatin has pro-inflammatory properties and is pro-atherogenic. We examined the potential impact of nesfatin and visfatin on atherosclerotic disease in 232 (113 black and 119 white) consecutive rheumatoid arthritis (RA) patients from 2 centers. Independent relationships of nesfatin and visfatin concentrations with metabolic risk factors, endothelial activation, carotid atherosclerosis and altered plaque stability were determined in multivariable regression models...
February 20, 2018: Peptides
https://www.readbyqxmd.com/read/29475000/quantitation-of-25-hydroxyvitamin-d-in-dried-blood-spots-by-2d-lc-ms-ms-without-derivatization-and-correlation-with-serum-in-adult-and-pediatric-studies
#6
Berit P Jensen, Rajneeta Saraf, Jing Ma, Sarah Berry, Cameron C Grant, Carlos A Camargo, Christiaan W Sies
BACKGROUND: Demand for measurement of 25-hydroxyvitamin D (25OHD) is growing and dried blood spot (DBS) sampling is attractive as samples are easier to collect, transport and store. METHODS: A 2D LC-MS/MS assay without derivatization was developed. DBS punches (3.2 mm) were ultrasonicated with d6 -25OHD3 in 70% methanol followed by hexane extraction, dry-down and reconstitution. The assay was validated and applied to two studies comparing whole blood adult DBS with serum samples (n = 40) and neonatal whole blood DBS with cord serum samples (n = 80)...
February 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29474991/endocrine-therapy-and-palbociclib-within-a-compassionate-use-program-in-heavily-pretreated-hormone-receptor-positive-her2-negative-metastatic-breast-cancer
#7
Christian Maurer, Arlindo R Ferreira, Samuel Martel, Matteo Lambertini, Noam Pondé, Philippe Aftimos, Evandro de Azambuja, Martine Piccart
This is a single center retrospective analysis of patients with hormone receptor-positive, HER2-negative metastatic breast cancer progressing after ≥ 4 treatment lines treated with palbociclib in combination with endocrine therapy within a compassionate use program. Thirty-four patients were included between 10/2015 and 02/2017, the majority (82.4%) being previously treated with mTOR inhibitors. Disease control rate was 52.9% and 24.4% at week 12 and 24. Overall progression-free survival was 3.1 months with no difference between mTOR inhibitor-pretreated (3...
February 20, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29474946/functional-results-and-patient-satisfaction-after-long-fusion-for-spinal-deformity-in-parkinson-s-disease
#8
C Scemama, G Mangone, R Bonaccorsi, H Pascal-Moussellard
BACKGROUND: Patients with Parkinson's disease often present abnormal posture or severe sagittal malalignment, causing significant disability. Surgical fusion is these cases shows high rates of complications, but may nevertheless provide functional benefit; however, this remains to be assessed. HYPOTHESIS: Long fusion for patients with Parkinson's disease and postural disorder could alleviate disability despite the high risk of complications. METHODS: We retrospectively reviewed 18 Parkinson patients treated by long fusion for spinal deformity...
February 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29474870/improving-revised-international-prognostic-scoring-system-ipss-r-pre-allogeneic-stem-cell-transplant-does-not-translate-into-better-post-transplant-outcomes-for-patients-with-myelodysplastic-syndromes-a-single-center-experience
#9
Musa Alzahrani, Maryse Power, Yasser Abou Mourad, Michael Barnett, Raewyn Broady, Donna Forrest, Alina Gerrie, Donna Hogge, Stephen Nantel, David Sanford, Kevin Song, Heather Sutherland, Cynthia Toze, Thomas Nevill, Sujaatha Narayanan
BACKGROUND: The natural history of patients with myelodysplastic syndromes (MDS) is variable. The revised international prognostic score (IPSS-R) is commonly used in practice to predict outcome in patients with MDS both at diagnosis and pre-transplant. However the effect of change in IPSS-R pre-allogeneic stem cell transplant with chemotherapy or hypomethylating agents on post-transplant outcomes is currently unknown. AIM: We assessed if improvement in IPSS-R prognostic score pre HSCT would result in improvement in clinical outcomes post-transplant...
February 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#10
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474852/forming-groups-of-aggressive-sows-based-on-a-predictive-test-of-aggression-does-not-affect-overall-sow-aggression-or-welfare
#11
Megan Verdon, R S Morrison, P H Hemsworth
This experiment examined the effects of group composition on sow aggressive behaviour and welfare. Over 6 time replicates, 360 sows (parity 1-6) were mixed into groups (10 sows per pen, 1.8 m2 /sow) composed of animals that were predicted to be aggressive (n = 18 pens) or groups composed of animals that were randomly selected (n = 18 pens). Aggressive sows were selected based on a model-pig test that has been shown to be related to the aggressive behaviour of parity 2 sows when subsequently mixed in groups...
February 20, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29474844/cardiac-output-in-pre-eclampsia-is-associated-with-the-presence-of-fetal-growth-restriction-not-gestation-at-onset-a-prospective-cohort-study
#12
Jasmine Tay, Lin Foo, Giulia Masini, Phillip R Bennett, Carmel M Mceniery, Ian B Wilkinson, Christoph C Lees
BACKGROUND AND OBJECTIVES: Pre-eclampsia (PE) and fetal growth restriction (FGR) are considered to be placentally-mediated disorders. The clinical manifestations are widely held to relate to gestation age at onset with early- and late-onset PE considered to be phenotypically distinct. Recent studies have reported conflicting findings in relation to cardiovascular function, and in particular cardiac output, in PE and FGR. STUDY DESIGN: We investigated maternal cardiovascular function in relation to clinical subtype in 45 pathological pregnancies (14 'PE only', 16 'FGR only', 15 'PE and FGR') and compared these with 107 healthy person observations...
February 20, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29474800/validity-of-the-4-compartment-model-using-dual-energy-x-ray-absorptiometry-derived-body-volume-in-overweight-individuals
#13
Malia N M Blue, Katie R Hirsch, Eric T Trexler, Abbie E Smith-Ryan
The purpose of the present study was to assess the validity of dual-energy X-ray absorptiometry (DXA) to estimate body volume (BV) for use in a four-compartment (4C) body composition model in an overweight/obese population. Body composition of 61 overweight/obese adults (Age: 37.3 ± 10.0 yrs; Height: 170.2 ± 9.5 cm; Body mass: 97.1 ± 17.4 kg) was measured by two methods: a criterion 4C model and a DXA-derived BV 4C model. For both models, bioelectrical impedance spectroscopy was used to estimate total body water; total body bone mineral content was measured by a full body DXA scan...
February 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29474728/longitudinal-changes-in-blood-metabolites-amino-acid-profile-and-oxidative-stress-markers-in-american-foxhounds-fed-a-nutrient-fortified-diet
#14
Alison N Beloshapka, Maria R C de Godoy, Rebecca A Carter, Andrea J Fascetti, Zengshou Yu, Bridgett J McIntosh, Kelly S Swanson, Preston R Buff
The objective of the present study was to evaluate the changes in blood metabolites, amino acid profile, and oxidative stress markers in American Foxhound dogs fed a nutrient-fortified endurance diet while undergoing unstructured endurance exercise over several months. Thirty-six adult American Foxhound dogs (mean age: 4.5, range 2-10 years and mean body weight (BW): 34.7, range: 23.1-46.9 kg) were selected to participate in the study. Prior to the study, all dogs consumed a commercial diet for 16 weeks. After collecting baseline blood samples, dogs were assigned to a standard commercial performance diet (control) or a nutrient-fortified dog food (test)...
February 21, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29474654/preliminary-investigation-of-radiation-dose-to-patients-from-cardiovascular-interventional-procedures-in-tanzania
#15
J E Ngaile, P K Msaki, R Mvungi, L J Schreiner
Although contemporary cardiac X-ray exams are typically set so benefits outweighs the risk, the growing use and increasing complexity of the cardiovascular interventional radiological (CVIR) procedures does increase the risk of radiation-related tissue effects and stochastic effects to the individual patients and the population. In view of these radiological concerns there is a need to investigate factors that influence the doses received by the patients and enable optimisation needed. The air kerma area product (KAP), cumulative air kerma (CAK) and fluoroscopy time (FT) to patients from two major CVIR procedures: coronary angiography (CA) and percutaneous coronary interventions (PCI), were obtained from two major hospitals in Tanzania...
February 21, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29474648/an-integrated-quantitative-index-for-measuring-chronic-multisite-pain-the-multiple-areas-of-pain-map-study
#16
Mark S Wallace, James North, Eric J Grigsby, Leonardo Kapural, Mahendra R Sanapati, Stephen G Smith, Channing Willoughby, Patrick J McIntyre, Steven P Cohen, Richard M Rosenthal, Shaik Ahmed, Ricardo Vallejo, Farshad M Ahadian, Thomas L Yearwood, Allen W Burton, Edward J Frankoski, Jai Shetake, Sherry Lin, Brad Hershey, Benjamin Rogers, Nitzan Mekel-Bobrov
Objective: Despite the high prevalence of chronic multisite pain, there is little consensus on methods to characterize it. Commonly used assessments report only one dimension of pain, that is, intensity, thus ignoring the spatial aspect of pain. We developed a novel pain quantification index, the Integrated Pain Quantification Index (IPQI), on a scale of 0 to 1 that integrates multiple distinct pain measures into a single value, thus representing multidimensional pain information with a single value...
February 21, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29474641/improvements-in-the-thermal-neutron-calibration-unit-tnf2-at-lnmri-ird
#17
A Astuto, S S Fernandes, K C S Patrão, E S Fonseca, W W Pereira, R T Lopes
The standard thermal neutron flux unit, TNF2, in the Brazilian National Ionizing Radiation Metrology Laboratory was rebuilt. Fluence is still achieved by moderating of four 241Am-Be sources with 0.6 TBq each. The facility was again simulated and redesigned with graphite core and paraffin added graphite blocks surrounding it. Simulations using the MCNPX code on different geometric arrangements of moderator materials and neutron sources were performed. The resulting neutron fluence quality in terms of intensity, spectrum and cadmium ratio was evaluated...
February 21, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29474563/effects-of-heat-stress-during-porcine-reproductive-and-respiratory-syndrome-virus-infection-on-metabolic-responses-in-growing-pigs
#18
K M Seelenbinder, L D Zhao, M D Hanigan, M W Hulver, R P McMillan, L H Baumgard, J T Selsby, J W Ross, N K Gabler, R P Rhoads
Heat stress and immune challenges negatively impact nutrient allocation and metabolism in swine, especially due to elevated heat load. In order to assess the effects of heat stress during porcine reproductive and respiratory syndrome virus (PRRSV) infection on metabolism, 9-week old crossbred barrows were individually housed, fed ad libitum, divided into four treatments: thermo-neutral (TN), thermo-neutral PRRSV infected (TP), heat stress (HS), and heat stress PRRSV infected (HP), and subjected to two experimental phases...
February 21, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29474545/simultaneous-determination-of-gatifloxacin-and-prednisolone-in-their-bulk-powder-synthetic-mixture-and-their-combined-ophthalmic-preparation-using-micellar-liquid-chromatography
#19
Reem N El Gammal, Mohammed E A Hammouda, Dalia R El-Wasseef, Saadia M El-Ashry
A simple rapid and accurate micellar high performance liquid chromatographic method was improved and validated for the analysis of mixture containing gatifloxacin sesquihydrate (GTF) and prednisolone acetate (PRED) in their synthetic mixture and their combined preparation. The separation was achieved using a C18 column, micellar mobile phase consisted of 0.2 M sodium dodecyl sulfate, 12.5% n-propanol and 0.3% triethylamine in 0.02 M orthophosphoric acid at pH 7.0 at a flow rate of 1 ml/min with UV detection at 270 nm...
February 21, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29474520/stability-indicating-rp-hplc-method-for-estimation-of-potential-impurities-in-ledipasvir-and-characterization-of-a-new-degradation-impurity
#20
R Siva Kumar, K V Sravan Kumar, L Kondareddy, K R Yogeshwara, Gangrade Manish, Jayachandran Jeenet, Kanyawar Nitesh
A new sensitive and stability indicating reverse phase high-performance liquid chromatography method has been developed for the quantitative determination of potential impurities of Ledipasvir, active pharmaceutical ingredient. Efficient chromatographic separation was achieved on waters × select column contains C18 stationary phase in gradient mode, quantitation at wavelength of 325 nm and mobile phase A is 50 mM ammonium formate pH 3.5 and mobile phase B is acetonitrile with flow rate 1.2 mL. The method was validated according to International Council for Hormonisation guideline, linearity studies has shown correlation coefficient value greater than 0...
February 21, 2018: Journal of Chromatographic Science
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