keyword
https://read.qxmd.com/read/38537201/prospective-evaluation-of-serum-free-thiols-in-inflammatory-bowel-disease-a-candidate-to-replace-c-reactive-protein-for-disease-activity-assessment
#1
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Pavel Sluka, Olga Niewiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited, with serum samples obtained concurrently for SFTs and routine bloods, plus fecal calprotectin and immunochemical tests were collected ±30 days from ileocolonoscopy...
March 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38537185/influence-of-body-mass-normalization-on-the-correlations-between-muscle-cross-sectional-area-and-physical-performance-outcomes-in-older-women
#2
JOURNAL ARTICLE
Ty B Palmer, Bailey M Palmer
AIMS: Normalization is a method used to account for body mass in clinical practice and research. It is unclear if this method will improve the correlation between muscle cross-sectional area (CSA) and physical performance. We examined the correlations between quadriceps muscle morphology parameters and physical performance outcomes in older women. Material and methods: Twenty older women participated in this study. Ultrasound imaging was used to measure quadriceps muscle CSA and echo intensity...
January 30, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537184/multiparametric-ultrasound-evaluation-of-liver-fibrosis-steatosis-and-viscosity-in-patients-with-chronic-liver-disease
#3
JOURNAL ARTICLE
Iulia Minciuna, Madalina Taru, Andreea Fodor, Oana Nicoara Farcau, Petra Fischer, Corina Radu, Monica Lupsor-Platon, Horia Stefanescu, Bogdan Procopet
AIMS: This study assessed the effectiveness of three ultrasound-based techniques (2D-SWE.PLUS, Att.PLUS, Vi.PLUS) for non-invasive evaluation of liver fibrosis, steatosis, and inflammation in chronic liver disease (CLD) patients.Materials and methods: Involving 209 consecutive compensated CLD patients, the study compared these ultrasound methods from Aixplorerwith standard Vibration-controlled Transient Elastography (VCTE) and Controlled Attenuation Parameter (CAP) from Fibroscan, alongside non-invasive serological markers...
February 7, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537176/toward-development-of-a-novel-proprioceptive-trail-making-test-comparing-healthy-dancers-and-non-dancers
#4
JOURNAL ARTICLE
Madison R Card, Anthony J Ryals
There is a pressing need for ecologically valid versions of traditional neuropsychological tests indexing executive function (EF), such as the Trail-Making Task (TMT), that incorporate movement and bodily awareness in healthy participants with varying abilities. We designed a proprioceptive version of the TMT (pTMT) that involved coordinated gross motor movement and proprioceptive awareness to investigate whether this measure of visual attention, task switching, and working memory positively correlated with a computerized version of the TMT (the dTMT)...
March 27, 2024: Perceptual and Motor Skills
https://read.qxmd.com/read/38537129/the-association-between-mean-arterial-pressure-and-acute-kidney-injury-reversal-among-decompensated-cirrhosis-patients
#5
JOURNAL ARTICLE
Giuseppe Cullaro, Andrew S Allegretti, Cynthia Fenton, Jin Ge, Kavish R Patidar, Jessica Rubin, Arjun Sharma, Jennifer C Lai
BACKGROUND: This study informs how mean arterial pressure (MAP) impacts AKI recovery among all patients hospitalized with cirrhosis, regardless of etiology. METHODS: We identified incident AKI episodes among subjects in our cohort of decompensated cirrhosis patients. AKI was defined as a ≥50% increase in creatinine (sCr) from an outpatient baseline (≥7 days prior) that required hospitalization. Linear mixed-effects models were completed to determine the impact between AKI recovery, MAP, and time...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537121/influence-of-low-level-tannin-supplementation-on-comparative-growth-performance-of-holstein-and-angus-x-holstein-cross-calf-fed-concentrate-based-finishing-diets-for-328-days
#6
JOURNAL ARTICLE
Pedro H V Carvalho, Brooke C Latack, Marcos V C Ferraz, Lester J R P Nolasco, Willi R Meireles, Heitor O M Oliveira, Richard A Zinn
The objective of the current study was to evaluate the effects of tannin and monensin supplementation in feedlot diets and breed (Holstein vs. Angus × Holstein) on growth performance, energetic efficiency, and carcass characteristics. Eighty purebred Holstein calves (HOL; initial body weight (BW) = 130 ± 5 kg) and eighty Angus × Holstein calves (AXH; initial BW = 129 ± 6 kg) were blocked by initial BW and randomly assigned to 40 pens. Dietary treatments consisted of a steam-flaked corn-based diet supplemented with 1) no feed additive (CON); 2) 30 mg of monensin/ kg of dry matter (DM) (MON; Rumensin 90, Elanco, Greenfield, IN); 3) 1...
March 27, 2024: Journal of Animal Science
https://read.qxmd.com/read/38537065/a-multicenter-study-of-venetoclax-based-treatment-for-patients-with-richter-transformation-of-chronic-lymphocytic-leukemia
#7
JOURNAL ARTICLE
Paul Joseph Hampel, Mahesh Swaminathan, Kerry A Rogers, Erin M Parry, Jan A Burger, Matthew S Davids, Wei Ding, Alessandra Ferrajoli, Jonathan Mitry Hyak, Nitin Jain, Saad S Kenderian, Yucai Wang, William G Wierda, Jennifer A Woyach, Sameer A Parikh, Philip A Thompson
Patients with chronic lymphocytic leukemia (CLL) who develop Richter transformation (RT) have a poor prognosis when treated with chemoimmunotherapy regimens used for de novo diffuse large B-cell lymphoma. Venetoclax, a BCL2 inhibitor, has single agent efficacy in patients with RT and is potentially synergistic with chemoimmunotherapy. In this multicenter, retrospective study, we evaluated 62 patients with RT who received venetoclax-based treatment outside of a clinical trial, in combination with a Bruton tyrosine kinase inhibitor (BTKi; n=28), R-CHOP (n=13), or intensive chemoimmunotherapy other than R-CHOP (n=21)...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537046/evaluation-of-early-ocular-discomfort-after-glaucoma-surgery-trabeculectomy-versus-ahmed-glaucoma-valve-implantation
#8
JOURNAL ARTICLE
Ricardo Y Abe, Douglas R Yamamoto, Fernanda Maria Silveira Souto, José Paulo Cabral Vasconcellos, Vital Paulino Costa
PURPOSE: This study aims to compare the initial ocular discomfort symptoms resulting from trabeculectomy and Ahmed glaucoma valve implantation surgeries. METHODS: A prospective comparative study was conducted. The evaluation of ocular discomfort employed a questionnaire designed to identify the frequency and severity of distinct symptoms: ocular pain, general discomfort, tearing, foreign body sensation, and burning. This questionnaire was administered prior to surgery as a baseline, and subsequently at 7, 30, and 90 days post-surgery...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38537043/choroidal-macrovascular-and-capillary-alterations-in-eyes-with-idiopathic-epiretinal-membranes
#9
JOURNAL ARTICLE
Ahmet M Hondur, Yavuz Kemal Aribas
PURPOSE: To evaluate the choroidal vascular alterations and effect of surgical treatment in the setting of idiopathic epiretinal membranes. METHODS: The structure of the choroid was studied in 33 patients with unilateral idiopathic epiretinal membrane using optical coherence tomography with enhanced depth imaging and optical coherence tomography angiography. Eyes with epiretinal membrane underwent 25-gauge vitrectomy with epiretinal membrane and internal limiting membrane peeling...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38537022/influence-of-genetic-polymorphisms-on-oral-health-related-quality-of-life-after-root-canal-treatment
#10
JOURNAL ARTICLE
Graciane E R Queiroz, Thuanny Castilho, Ludmila Silva Guimarães, Vania Gomes Moraes, Erlange Andrade Borges da Silva, Erika Calvano Küchler, Alice Corrêa Silva-Sousa, Manoel Damião Sousa-Neto, Lívia Azeredo Alves Antunes, Leonardo Santos Antunes
UNLABELLED: To evaluate the impact of genetic polymorphisms in interleukins (IL1A rs17561, rs1304037; IL10 rs1800871; IL1RN rs9005), nitric oxide (NOS2 rs2779249, rs2897518) and suppressor of cytokine signaling (SOCS1 rs243327, rs33977706) on oral health-related quality of life (OHRQoL) of patients under-going root canal treatment (RCT). METHODS: The sample consisted of 108 participants, presenting single-rooted teeth with asymptomatic periapical periodontitis. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) before, seven, and 30 days after RCT...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38537018/natural-canal-deviation-and-dentin-thickness-of-mesial-root-canals-of-mandibular-first-molars-assessed-by-microcomputed-tomography
#11
JOURNAL ARTICLE
Carolina Alonso Amorim, Marília F Marceliano-Alves, Isabelle Louise Gomes, José C Provenzano, Flávio R F Alves
The aim of this study was to assess the centralization and dentin thickness of mesial root canals of the first mandibular molars by microcomputed tomography (micro-CT). Material and methods: Ninety-nine mandibular molars of Vertucci's type IV canals were scanned by micro-CT. The mesiodistal deviation and centroid were assessed, in both mesiobuccal (MB) and mesiolingual (ML) canals, for the apical 4mm and the full canal length. Results: The dentin thickness was similar for both MB and ML canals. The narrowest thickness was in the distal wall of an MB canal (0...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#12
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536881/small-intestine-bacterial-overgrowth-is-associated-with-increased-campylobacter-and-epithelial-injury-in-duodenal-biopsies-of-bangladeshi-children
#13
JOURNAL ARTICLE
Shah Mohammad Fahim, Jeffrey R Donowitz, Ekaterina Smirnova, Ning-Juin Jan, Subhasish Das, Mustafa Mahfuz, S M Abdul Gaffar, William A Petri, Chelsea Marie, Tahmeed Ahmed
Small intestine bacterial overgrowth (SIBO) has been associated with enteric inflammation, linear growth stunting, and neurodevelopmental delays in children from low-income countries. Little is known about the histologic changes or epithelial adherent microbiota associated with SIBO. We sought to describe these relationships in a cohort of impoverished Bangladeshi children. Undernourished 12-18-month-old children underwent both glucose hydrogen breath testing for SIBO and duodenoscopy with biopsy. Biopsy samples were subject to both histological scoring and 16s rRNA sequencing...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536873/quality-and-sustainability-of-ethiopia-s-national-surgical-indicators
#14
JOURNAL ARTICLE
Kayleigh R Cook, Zebenay B Zeleke, Ephrem Gebrehana, Daniel Burssa, Bantalem Yeshanew, Atkilt Michael, Yoseph Tediso, Taylor Jaraczewski, Chris Dodgion, Andualem Beyene, Katherine R Iverson
In 2015, the Ethiopian Federal Ministry of Health (FMOH) developed the Saving Lives through Safe Surgery (SaLTS) initiative to improve national surgical care. Previous work led to development and implementation of 15 surgical key performance indicators (KPIs) to standardize surgical data practices. The objective of this project is to investigate current practices of KPI data collection and assess quality to improve data management and strengthen surgical systems. The first portion of the study documented the surgical data collection process including methods, instruments, and effectiveness at 10 hospitals across 2 regions in Ethiopia...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536838/comparative-evaluation-of-different-modalities-for-measuring-in-vivo-carnosine-levels
#15
JOURNAL ARTICLE
Alok R Amraotkar, David Hoetker, Mohammad J Negahdar, Chin K Ng, Pawel Lorkiewicz, Ugochukwu S Owolabi, Shahid P Baba, Aruni Bhatnagar, Timothy E O'Toole
Carnosine is an endogenous di-peptide (β-alanine -L- histidine) involved in maintaining tissue homeostasis. It is most abundant in skeletal muscle where its concentration has been determined in biopsy samples using tandem mass spectrometry (MS-MS). Carnosine levels can also be assessed in intact leg muscles by proton magnetic resonance spectroscopy (1H-MRS) or in blood and urine samples using mass spectrometry. Nevertheless, it remains uncertain how carnosine levels from these distinct compartments are correlated with each other when measured in the same individual...
2024: PloS One
https://read.qxmd.com/read/38536807/turkish-cultural-adaptation-validity-and-reliability-of-the-stroke-activity-scale-in-individuals-with-hemiparesis
#16
JOURNAL ARTICLE
Ayşe Göktaş, Volkan Türkmen, Fulya Damla Çolak, Gamze Ekici
AIM: The aim of this study was to make the Turkish cultural adaptation of the the Stroke Activity Scale (SAS). METHOD: This study was designed as a methodological research. The psychometric properties of the SAS scale were evaluated by validity and reliability analyses. RESULTS: The average age of 84 stroke patients (mean ± SD) was 59.52 ± 14.03 years. Kaiser-Meyer-Olkin (0.816) and Bartlett's Test of Sphericity (χ2 = 288...
March 27, 2024: Topics in Stroke Rehabilitation
https://read.qxmd.com/read/38536658/development-of-diagnostic-algorithm-for-cushing-s-syndrome-a-tertiary-centre-experience
#17
JOURNAL ARTICLE
A Efthymiadis, H Loo, B Shine, T James, B Keevil, J W Tomlinson, A Pal, R Pofi
PURPOSE: No consensus exists as the gold standard for Cushing's Syndrome (CS) screening. This study aimed to evaluate the diagnostic accuracy and utility of late-night salivary cortisol (LNSC) and cortisone (LNSE), overnight dexamethasone suppression test (ODST), and urinary free cortisol (UFC) in developing a screening algorithm for CS. METHODS: A retrospective, single-centre analysis on 93 adult patients referred to the Oxford Centre for Diabetes, Endocrinology, and Metabolism for CS evaluation (2017-2022)...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536636/a-direct-comparison-of-three-screening-methods-for-autism-spectrum-disorder-in-a-high-likelihood-sibling-population
#18
JOURNAL ARTICLE
Chui Mae Wong, Nurhafizah Mohd Zambri, Hui Hua Fan, Lily H S Lau, L Mary Daniel, Hwan Cui Koh
Targeted screening of children at increased likelihood of autism is recommended. However, autism screening tools are usually validated for use mainly in low-likelihood populations. This study compared the accuracy of the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F), the ASDetect app, and the Social Attention and Communication Surveillance, Revised (SACS-R). Siblings of autistic children underwent autism screening at 12, 18 and 30 months old. At each visit, caregivers completed the M-CHAT-R/F and ASDetect while trained nurses tested the siblings using the SACS-R...
March 27, 2024: Journal of Autism and Developmental Disorders
https://read.qxmd.com/read/38536629/association-of-premorbid-glp-1ra-and-sglt-2i-prescription-alone-and-in-combination-with-covid-19-severity
#19
JOURNAL ARTICLE
Klara R Klein, Trine J Abrahamsen, Anna R Kahkoska, G Caleb Alexander, Christopher G Chute, Melissa Haendel, Stephanie S Hong, Hemalkumar Mehta, Richard Moffitt, Til Stürmer, Kajsa Kvist, John B Buse
INTRODUCTION: People with type 2 diabetes are at heightened risk for severe outcomes related to COVID-19 infection, including hospitalization, intensive care unit admission, and mortality. This study was designed to examine the impact of premorbid use of glucagon-like peptide-1 receptor agonist (GLP-1RA) monotherapy, sodium-glucose cotransporter-2 inhibitor (SGLT-2i) monotherapy, and concomitant GLP1-RA/SGLT-2i therapy on the severity of outcomes in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
March 27, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38536623/gut-barrier-dysfunction-and-the-risk-of-icu-acquired-bacteremia-a-case-control-study
#20
JOURNAL ARTICLE
Meri R J Varkila, Diana M Verboom, Lennie P G Derde, Tom van der Poll, Marc J M Bonten, Olaf L Cremer
BACKGROUND: Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative importance of gut translocation as a source for ICU-acquired enterococcal bacteremia of unknown origin. METHODS: We conducted a nested case-control study in two mixed medical-surgical tertiary ICUs in the Netherlands among patients enrolled between 2011 and 2018...
March 27, 2024: Annals of Intensive Care
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