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https://www.readbyqxmd.com/read/28822325/are-there-regional-tendencies-toward-controversial-screening-practices-a-study-of-prostate-and-breast-cancer-screening-in-a-medicare-population
#1
Eric Raffin, Tracy Onega, Julie Bynum, Andrea Austin, Donald Carmichael, Kristen Bronner, Philip Goodney, Elias S Hyams
INTRODUCTION: Prostate and breast cancer screening in older patients continue to be controversial. Balancing the desire for early detection with avoidance of over-diagnosis has led to competing and contradictory guidelines for both practices. Despite similarities, it is not known how these screening practices are related at the regional level. In this study, we examined how screening PSA and mammography are related within healthcare regions, and, to better understand what may be driving these practices, whether they are associated with local intensity of care...
August 16, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28822267/a-similar-pro-anti-inflammatory-cytokine-balance-is-present-in-the-airways-of-competitive-athletes-and-non-exercising-asthmatics
#2
Marcin Kurowski, Janusz Jurczyk, Agnieszka Olszewska-Ziąber, Marzanna Jarzębska, Hubert Krysztofiak, Marek L Kowalski
PURPOSE: Intensive exercise modifies airway inflammation and infection susceptibility. We aimed to determine the effect of exercise on pro- and anti-inflammatory cytokine (TNF-α, IL-1ra, IL-10) and innate immunity protein (HSPA1, sCD14) levels in exhaled breath condensate (EBC) and nasal secretions of competitive athletes, non-exercising asthmatics and healthy controls (HC). MATERIAL AND METHODS: The study group consisted of 15 competitive athletes (five speed skaters and ten swimmers) aged 15-25...
August 16, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28822262/evaluating-the-influence-of-at-risk-alcohol-use-on-factors-associated-with-smoking-cessation-combining-laboratory-and-ecological-momentary-assessment
#3
Joanna R Sells, Andrew J Waters, R Ross MacLean
OBJECTIVE: Most smokers want to quit but most cessation attempts end in failure. Alcohol consumption is associated with smoking behavior and relapse. We examined the associations between severity of drinking and psychological processes during a cessation attempt in the laboratory and during a quit attempt. METHODS: Smokers (N=209) enrolled in a smoking cessation study were followed from 2 weeks pre-quit through 4 weeks post-quit. Participants scoring 0-7 and 8-15 on the Alcohol Use Disorders Identification Test (AUDIT) were classified as low-risk and high-risk drinkers, respectively...
July 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28822258/photochemical-oxidation-of-dimethylsulphide-to-dimethylsulphoxide-in-estuarine-and-coastal-waters
#4
Günther Uher, J Julian Pillans, Angela D Hatton, Robert C Upstill-Goddard
Dimethylsulphide (DMS) photo-oxidation and dimethylsulphoxide (DMSO) photoproduction were estimated in 26 laboratory irradiations of coastal samples from NE England (Tyne estuary) and W Scotland (Loch Linnhe and River Nant at Taynuilt). Pseudo-first order rate constants of DMS photo-oxidation (0.038 h(-1) to 0.345 h(-1)) and DMSO photo-production (0.017 h(-1) to 0.283 h(-1)) varied by one order of magnitude and were lowest in the coastal North Sea. Estuarine samples (salinity S < 30) had a mean DMSO yield of 96 ± 16% (n = 14), consistent with 1:1 M conversion via photosensitised oxidation by singlet oxygen...
August 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28822240/statin-use-and-venous-thromboembolism-in-cancer-a-large-active-comparator-propensity-score-matched-cohort-study
#5
Sherif M El-Refai, Esther P Black, Val R Adams, Jeffery C Talbert, Joshua D Brown
BACKGROUND: Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS: Patients with newly diagnosed cancer were followed for up to one year in a healthcare claims database (2010-2013). Three treatment groups included statin users, non-statin cholesterol lowering medication users, and an untreated group with pre-existing indications for statin therapy (hyperlipidemia, diabetes, or heart disease)...
August 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28822224/is-it-necessary-for-all-samples-to-quantify-25ohd2-and-25ohd3-using-lc-ms-ms-in-clinical-practice
#6
Songlin Yu, Ruiping Zhang, Weiyan Zhou, Xinqi Cheng, Qian Cheng, Liangyu Xia, Shaowei Xie, Yicong Yin, Dandan Sun, Wei Su, Ling Qiu
BACKGROUND: The demand for vitamin D testing is increasing in China. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) immunoassay is specific and accurate but requires expensive equipment, experienced operators, and complicated pretreatment of serum. Automated immunoassays are simple and convenient but only determine total 25-hydroxyvitamin D (25OHD). The objective of this study was to quantify 25OHD2 and 25OHD3 in patients to assist clinical physicians and laboratory directors in choosing the most appropriate method to determine 25OHD...
August 19, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28822212/comparison-of-start-and-salt-triage-methodologies-to-reference-standard-definitions-and-to-a-field-mass-casualty-simulation
#7
Salvatore Silvestri, Adam Field, Neal Mangalat, Tory Weatherford, Christopher Hunter, Zoe McGowan, Zachary Stamile, Trevor Mattox, Tanner Barfield, Aarian Afshari, George Ralls, Linda Papa
OBJECTIVES: We compared Sort, Assess, Lifesaving Intervention, Treatment/Transport (SALT) and Simple Triage and Rapid Treatment (START) triage methodologies to a published reference standard, and evaluated the accuracy of the START method applied by emergency medical services (EMS) personnel in a field simulation. DESIGN: Simulated mass casualty incident (MCI). Paramedics trained in START triage assigned each victim to green (minimal), yellow (delayed), red (immediate), or black (dead) categories...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28822210/evaluation-of-the-association-between-disaster-training-and-confidence-in-disaster-response-among-graduate-medical-trainees-a-cross-sectional-study
#8
Andrew Grock, Adam R Aluisio, Elizabeth Abram, Patricia Roblin, Bonnie Arquilla
OBJECTIVE: Disasters by definition overwhelm the resources of a hospital and may require a response from a range of practitioners. Disaster training is part of emergency medicine (EM) resident curricula, but less emphasized in other training programs. This study aimed to compare disaster educational training and confidence levels among resident trainees from multiple specialties. DESIGN: A structured questionnaire assessed graduate medical training in disaster education and self-perceived confidence in disaster situations...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28822156/-hplc-ms-ms-determination-of-residual-amount-of-4-plant-growth-retardants-in-6-dried-root-and-rhizome-herbs
#9
Yu-Yao Zhai, Bao-Lin Guo
HPLC-MS/MS was applied to the determination of residual amount of plant growth retardant such as paclobutrazol, daminozide, chlormequat and mepiquat chloride in dried root and rhizome herbs. The sample was extracted twice with acetonitrile containing 0.1% formic acid. The separation was performed on a Waters Atlantis HILIC column with an elution system consisting of acetonitrile-5 mmol•L⁻¹ ammonium acetate solution with 0.1% formic acid, methanol and acetonitrile. The MS spectrum was acquired in positive mode with multiple reactions monitoring (MRM)...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822077/increased-serum-levels-of-fetuin-b-in-patients-with-coronary-artery-disease
#10
Kefu Zhu, Yuming Wang, Pengqin Shu, Qinyi Zhou, Jinzhou Zhu, Wenjing Zhou, Changqing Du, Chenkai Xu, Xiaowei Liu, Lijiang Tang
BACKGROUND: Recent evidence indicates a pivotal role for fetuin B, one of the cystatin superfamily of cysteine protease inhibitors, in the pathogenesis of metabolic diseases. This study investigated whether serum fetuin B levels are associated with the presence of coronary artery disease. METHODS: Serum fetuin B levels were assessed in 87 patients with coronary artery disease (41 with acute coronary syndromes and 46 with stable angina pectoris) and 87 healthy controls using an enzyme-linked immunosorbent assay...
August 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28822076/studies-of-the-benzopyran-class-of-selective-cox-2-inhibitors-using-3d-qsar-and-molecular-docking
#11
Dharmendra K Yadav, Saloni, Praveen Sharma, Sanjeev Misra, Harpreet Singh, Ricardo L Mancera, Kang Kim, Cheongyun Jang, Mi-Hyun Kim, Horacio Pérez-Sánchez, Eun Ha Choi, Surendra Kumar
The Gaussian-based 3D-QSAR studies for 58 selective COX-2 (cyclooxygenase-2) inhibitors belonging to benzopyran chemical class were performed. Partial least squares analysis produced statistically significant model with (R training(2)  = 0.866) and predictability (Q training(2)  = 0.66, Q test(2)  = 0.846). The 3D-QSAR model includes steric, electrostatic, hydrophobic, and hydrogen bond acceptor field indicators, whereas the potential field contributions indicate that the steric and hydrophobic features of the molecules play an important role in governing their biological activity...
August 18, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28822067/association-between-serum-osteocalcin-and-body-mass-index-a-systematic-review-and-meta-analysis
#12
Hamed Kord-Varkaneh, Kurosh Djafarian, Masoud Khorshidi, Sakineh Shab-Bidar
PURPOSE: Osteocalcin is considered as a bone-derived hormone affecting on the body fat distribution and body mass index. Several cross-sectional studies have investigated the association between serum osteocalcin and body mass index. The aim of this study was to summarize the evidence on the relationship between serum osteocalcin and body mass index. METHODS: We conducted a complete search up to November 2016 in PubMed and SCOPUS and reviewed reference list of all relevant articles and reviews...
August 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28822055/social-inequalities-in-children-s-oral-health-related-quality-of-life-the-generation-r-study
#13
Lea Kragt, Eppo B Wolvius, Hein Raat, Vincent W V Jaddoe, Edwin M Ongkosuwito
PURPOSE: Oral health-related quality of life (OHRQoL) is the most important patient-reported outcome measure in oral health research. The purpose of the present research was to study the association of family socioeconomic position (SEP) with children's OHRQoL. METHODS: This cross-sectional study was embedded in the Generation R Study, a population-based cohort study conducted in Rotterdam, The Netherlands. For the present study, OHRQoL was assessed of 3871 ten-year old children...
August 18, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28822023/pulse-contour-derived-cardiac-output-measurements-in-morbid-obesity-influence-of-actual-ideal-and-adjusted-bodyweight
#14
Chantal A Boly, Pieter Schraverus, Floris van Raalten, Jan-Willem Coumou, Christa Boer, Simone van Kralingen
The non-invasive Nexfin cardiac output (CO) monitor shows a low level of agreement with the gold standard thermodilution method in morbidly obese patients. Here we investigate whether this disagreement is related to excessive bodyweight, and can be improved when bodyweight derivatives are used instead. We performed offline analyses of cardiac output recordings of patient data previously used and partly published in an earlier study by our group. In 30 morbidly obese patients (BMI > 35 kg/m(2)) undergoing laparoscopic gastric bypass, cardiac output was simultaneously determined with PiCCO thermodilution and Nexfin pulse-contour method...
August 18, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28822017/validation-of-a-non-contact-screening-device-for-the-combination-of-sleep-disordered-breathing-and-periodic-limb-movements-in-sleep
#15
Gerhard Weinreich, Sarah Terjung, Yi Wang, Stefanie Werther, Alberto Zaffaroni, Helmut Teschler
PURPOSE: Recent studies found that the non-contact screening device SleepMinder (ResMed Sensor Technologies, Dublin, Ireland) detects sleep-disordered breathing (SDB) with high diagnostic accuracy in cohorts suspected of this disorder. However, it was reported that in patients with periodic limb movement in sleep (PLMS), this non-contact device overestimates the apnea-hypopnea index (AHI). We aimed to overcome this limitation by introducing the novel sleep disorder index (SDI) which is sum of the AHI and the period limb movement index (PLMI)...
August 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28821966/application-of-transcutaneous-ultrasonography-for-the-diagnosis-of-muscle-mass-loss-in-patients-with-liver-cirrhosis
#16
Kazufumi Kobayashi, Hitoshi Maruyama, Soichiro Kiyono, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Tetsuhiro Chiba, Naoya Kato, Tadashi Yamaguchi
BACKGROUND: To propose an ultrasound-based parameter for the diagnosis of muscle mass loss (MML) in cirrhosis. METHODS: This is an IRB-approved cross-sectional study (October 2013 to January 2017) with written informed consent including 357 subjects-234 cirrhosis and 123 controls. MML was diagnosed using the skeletal muscle index at the L3 level (L3-SMI) on computed tomography (CT). Transcutaneous ultrasound was used to demonstrate a cross section of the right iliopsoas muscle, and the iliopsoas muscle index (IP index) was defined by the iliopsoas muscle area/height(2) (mm(2)/m(2))...
August 18, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28821962/influence-of-aerobic-fitness-on-vasoreactivity-in-young-men
#17
Preston L Bell, Edward T Kelley, Stephanie M McCoy, Daniel P Credeur
Previous work has demonstrated a direct relationship between aerobic fitness and vasodilatory function (i.e., flow-mediated dilation; FMD); however, the relation between aerobic fitness and vasoconstrictor responsiveness (i.e., low flow-mediated constriction; L-FMC), and the overall vasoactive range (FMD + L-FMC) is unclear. PURPOSE: To test the hypothesis that L-FMC and the overall vasoactive range (FMD + L-FMC) will be related to aerobic fitness in young, healthy men. METHODS: Twenty men (age: 23 ± 5 years) were recruited, and divided evenly into a higher (HF) vs...
August 18, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28821950/the-effects-of-supramaximal-versus-submaximal-intensity-eccentric-training-when-performed-until-volitional-fatigue
#18
Joel R Krentz, Philip D Chilibeck, Jonathan P Farthing
PURPOSE: Our purpose was to compare supramaximal versus submaximal intensity eccentric training performed until volitional fatigue. METHODS: Thirty-two young adults (19 males) were randomized into one of three groups: (1) ECC110 performed eccentric (ECC) only contractions at 110% of concentric (CON) 1-repetition maximum (1RM); (2) ECC80 performed ECC only contractions at 80% of CON 1RM; (3) a control group. Training progressed from 3 to 6 sets of unilateral ECC training of the elbow flexors over 8 weeks, with each set performed until volitional fatigue...
August 18, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28821947/the-influence-of-microvascular-injury-on-native-t1-and-t2-relaxation-values-after-acute-myocardial-infarction-implications-for-non-contrast-enhanced-infarct-assessment
#19
Lourens F H J Robbers, Robin Nijveldt, Aernout M Beek, Paul F A Teunissen, Maurits R Hollander, P Stefan Biesbroek, Henk Everaars, Peter M van de Ven, Mark B M Hofman, Niels van Royen, Albert C van Rossum
OBJECTIVES: Native T1 mapping and late gadolinium enhancement (LGE) imaging offer detailed characterisation of the myocardium after acute myocardial infarction (AMI). We evaluated the effects of microvascular injury (MVI) and intramyocardial haemorrhage on local T1 and T2* values in patients with a reperfused AMI. METHODS: Forty-three patients after reperfused AMI underwent cardiovascular magnetic resonance imaging (CMR) at 4 [3-5] days, including native MOLLI T1 and T2* mapping, STIR, cine imaging and LGE...
August 18, 2017: European Radiology
https://www.readbyqxmd.com/read/28821920/tspo-pet-for-glioma-imaging-using-the-novel-ligand-18-f-ge-180-first-results-in-patients-with-glioblastoma
#20
Nathalie L Albert, M Unterrainer, D F Fleischmann, S Lindner, F Vettermann, A Brunegraf, L Vomacka, M Brendel, V Wenter, C Wetzel, R Rupprecht, J-C Tonn, C Belka, P Bartenstein, M Niyazi
OBJECTIVE: The 18-kDa mitochondrial translocator protein (TSPO) was reported to be upregulated in gliomas. (18)F-GE-180 is a novel 3rd generation TSPO receptor ligand with improved target-to-background contrast compared to previous tracers. In this pilot study, we compared PET imaging with (18)F-GE-180 and MRI of patients with untreated and recurrent pretreated glioblastoma. METHODS: Eleven patients with histologically confirmed IDH wildtype gliomas (10 glioblastomas, 1 anaplastic astrocytoma) underwent (18)F-GE-180 PET at initial diagnosis or recurrence...
August 19, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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