keyword
MENU ▼
Read by QxMD icon Read
search

Gate control

keyword
https://www.readbyqxmd.com/read/29146521/hla-dq-gluten-tetramer-blood-test-accurately-identifies-patients-with-and-without-celiac-disease-in-absence-of-gluten-consumption
#1
Vikas K Sarna, Knut E A Lundin, Lars Mørkrid, Shuo-Wang Qiao, Ludvig M Sollid, Asbjørn Christophersen
BACKGROUND & AIMS: Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten proteins. A diagnosis of celiac disease based on serologic and histologic evidence and duodenal histology requires patients to be on gluten-containing diets. The growing number of individuals adhering to a gluten-free diet (GFD) without exclusion of celiac disease complicates its detection. HLA-DQ-gluten tetramers can be used to detect gluten-specific T cells in blood of patients with celiac disease, even if they are on a GFD...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29146176/neosaxitoxin-a-paralytic-shellfish-poison-toxin-effectively-manages-bucked-shins-pain-as-a-local-long-acting-pain-blocker-in-an-equine-model
#2
Gricel Riquelme, Joaquín M Sepúlveda, Zaki Al Ghumgham, Miguel Del Campo, Cecilia Montero, Nestor Lagos
Local anesthesia is an effective method to control pain. Neosaxitoxin is a phycotoxin whose molecular mechanism includes a reversible inhibition of voltage-gated sodium channels at the axonal level, impeding nerve impulse propagation. The present study was designed to evaluate the clinical efficacy of Neosaxitoxin as a local long-acting pain blocker in horse bucked shins, and it was found to effectively control pain. While Neosaxitoxin and Gonyautoxin, another Paralytic Shellfish Poison (PSP) toxin, have been successfully used in humans as long-lasting pain blockers, this finding marks the first time a PSP has been shown to have an established effect in veterinary medicine...
November 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29144127/area-controllable-stamping-of-semicrystalline-copolymer-ionogels-for-solid-state-electrolyte-gated-transistors-and-light-emitting-devices
#3
Hyun Je Kim, Hae Min Yang, Jaemok Koo, Moon Sung Kang, Kihyon Hong, Keun Hyung Lee
Two types of thin-film electrochemical devices (electrolyte-gated transistors and electrochemical light-emitting cells) are demonstrated by using area-controllable ionogel patches generated by transfer stamping. For the successful transfer of ionogel patches on various target substrates thermoreversible gelation by phase-separated polymer crystals within the ionogel is essential because it allows the gel to form a conformal contact with the acceptor substrate, and thereby lowering the overall Gibbs energy of the system upon transfer of the ionogel...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29140977/low-cost-and-open-source-multi-fluorescence-imaging-system-for-teaching-and-research-in-biology-and-bioengineering
#4
Isaac Nuñez, Tamara Matute, Roberto Herrera, Juan Keymer, Timothy Marzullo, Timothy Rudge, Fernán Federici
The advent of easy-to-use open source microcontrollers, off-the-shelf electronics and customizable manufacturing technologies has facilitated the development of inexpensive scientific devices and laboratory equipment. In this study, we describe an imaging system that integrates low-cost and open-source hardware, software and genetic resources. The multi-fluorescence imaging system consists of readily available 470 nm LEDs, a Raspberry Pi camera and a set of filters made with low cost acrylics. This device allows imaging in scales ranging from single colonies to entire plates...
2017: PloS One
https://www.readbyqxmd.com/read/29140681/orthogonal-operation-of-constitutional-dynamic-networks-consisting-of-dna-tweezer-machines
#5
Liang Yue, Shan Wang, Alessandro Cecconello, Jean-Marie Lehn, Itamar Willner
Overexpression or down-regulation of cellular processes are often controlled by dynamic chemical networks. Bioinspired by nature, we introduce constitutional dynamic networks (CDNs) as systems that emulate principle of the nature processes. The CDNs comprise of dynamically exchangeable equilibrated constituents that respond to external triggers by adapting the composition of the dynamic mixture to the energetic stabilization of the constituents. We introduce a nucleic acid-based CDN that includes four exchangeable and mechanically-triggered tweezers AA', BB', AB' and BA' existing in close, close, open and open configurations, respectively...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29139188/biomimic-peptide-gated-nanoporous-membrane-for-on-demand-molecule-transport
#6
Kai Xiao, Kai Wu, Lu Chen, Xiang-Yu Kong, Yuqi Zhang, Liping Wen, Lei Jiang
The controllable molecule transport is crucial to realize many highly valuable applications both in vivo and in vitro. Nanoporous membrane, with nanoscopic pores, high porosity, uniform pore dimension, and controllable surface chemical properties, hold tremendous potential to achieve this function. Here, we report a nano-gating system for on-demand molecule transport based on peptide-gated nanoporous membrane. Acting as gatekeeper, the peptides introduced to the nanoporous membrane provide an opportunity to realize on-demand on-off-states transport profiles via reversible conformational switch of peptides...
November 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29138838/effects-of-scn9a-gene-modification-on-na-channel-and-the-expression-of-nerve-growth-factor-in-a-rat-model-of-diarrhea%C3%A2-predominant-irritable-bowel-syndrome
#7
Yong-Yan Cai, Chen Li, Zhi-Xin Yan, Na Ma, Fang-Fang Li
The aim of the present study was to identify whether the sodium voltage-gated channel alpha subunit 9 (SCN9A) gene modification is a potential treatment for diarrhea‑predominant irritable bowel syndrome (D‑IBS), via regulating the Na+ channel and the expression of nerve growth factor (NGF). The recombinant adenovirus vector of the SCN9A gene was established, and rat colon cells were isolated for SCN9A gene modification. All subjects were divided into four groups: i) The SCN9A‑modified (D‑IBS rat model implanted with SCN9A‑modified colon cells), ii) negative control (NC; D‑IBS rat model implanted with colon cells without SCN9A gene modification), iii) blank (D‑IBS rat model without any treatment) and iv) normal (normal rats without any treatment)...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138504/facilitation-of-information-processing-in-the-primary-somatosensory-area-in-the-ball-rotation-task
#8
Toshiaki Wasaka, Tetsuo Kida, Ryusuke Kakigi
Somatosensory input to the brain is known to be modulated during voluntary movement. It has been demonstrated that the response in the primary somatosensory cortex (SI) is generally gated during simple movement of the corresponding body part. This study investigated sensorimotor integration in the SI during manual movement using a motor task combining movement complexity and object manipulation. While the amplitude of M20 and M30 generated in the SI showed a significant reduction during manual movement, the subsequent component (M38) was significantly higher in the motor task than in the stationary condition...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136384/field-effect-modulation-of-heterogeneous-charge-transfer-kinetics-at-back-gated-2d-mos2-electrodes
#9
Yan Wang, Chang-Hyun Kim, Youngdong Yoo, James E Johns, C Daniel Frisbie
The ability to improve and to modulate the heterogeneous charge transfer kinetics of two dimensional (2D) semiconductors, such as MoS2, is a major challenge for electrochemical and photoelectrochemical applications of these materials. Here we report a continuous and reversible physical method for modulating the heterogeneous charge transfer kinetics at a monolayer MoS2 working electrode supported on a SiO2/p-Si substrate. The heavily doped p-Si substrate serves as a back gate electrode; application of a gate voltage (VBG) to p-Si tunes the electron occupation in the MoS2 conduction band and shifts the conduction band edge position relative to redox species dissolved in electrolyte in contact with the front side of the MoS2...
November 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/29136106/cell-type-specific-burst-firing-interacts-with-theta-and-beta-activity-in-prefrontal-cortex-during-attention-states
#10
B Voloh, T Womelsdorf
Population-level theta and beta band activity in anterior cingulate and prefrontal cortices (ACC/PFC) are prominent signatures of self-controlled, adaptive behaviors. But how these rhythmic activities are linked to cell-type specific activity has remained unclear. Here, we suggest such a cell-to-systems level linkage. We found that the rate of burst spiking events is enhanced particularly during attention states and that attention-specific burst spikes have a unique temporal relationship to local theta and beta band population-level activities...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29132613/identification-and-management-of-shigella-infection-in-children-with-diarrhoea-a-systematic-review-and-meta-analysis
#11
Kirkby D Tickell, Rebecca L Brander, Hannah E Atlas, Jeffrey M Pernica, Judd L Walson, Patricia B Pavlinac
BACKGROUND: Shigella infections are a leading cause of diarrhoeal death among children in low-income and middle-income countries. WHO guidelines reserve antibiotics for treating children with dysentery. Reliance on dysentery for identification and management of Shigella infection might miss an opportunity to reduce Shigella-associated morbidity and mortality. We aimed to systematically review and evaluate Shigella-associated and dysentery-associated mortality, the diagnostic value of dysentery for the identification of Shigella infection, and the efficacy of antibiotics for children with Shigella or dysentery, or both...
December 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29131863/long-term-retinal-cone-rescue-using-a-capsid-mutant-aav8-vector-in-a-mouse-model-of-cnga3-achromatopsia
#12
Xufeng Dai, Ying He, Hua Zhang, Yangyang Zhang, Yan Liu, Muran Wang, Hao Chen, Ji-Jing Pang
Adeno-associated virus (AAV) vectors are important gene delivery tools for the treatment of many recessively inherited retinal diseases. For example, a wild-type (WT) AAV5 vector can deliver a full-length Cnga3 (cyclic nucleotide-gated channel alpha-3) cDNA to target cells of the cone photoreceptor function loss 5 (cpfl5) mouse, a spontaneous animal model of achromatopsia with a Cnga3 mutation. Gene therapy restores cone-mediated function and blocks cone degeneration in the mice. However, since transgene expression delivered by an AAV vector shows relatively short-term effectiveness, this cannot be regarded as a very successful therapy...
2017: PloS One
https://www.readbyqxmd.com/read/29129436/effects-of-teriparatide-and-risedronate-on-new-fractures-in-post-menopausal-women-with-severe-osteoporosis-vero-a-multicentre-double-blind-double-dummy-randomised-controlled-trial
#13
David L Kendler, Fernando Marin, Cristiano A F Zerbini, Luis A Russo, Susan L Greenspan, Vit Zikan, Alicia Bagur, Jorge Malouf-Sierra, Péter Lakatos, Astrid Fahrleitner-Pammer, Eric Lespessailles, Salvatore Minisola, Jean Jacques Body, Piet Geusens, Rüdiger Möricke, Pedro López-Romero
BACKGROUND: No clinical trials have compared osteoporosis drugs with incident fractures as the primary outcome. We compared the anti-fracture efficacy of teriparatide with risedronate in patients with severe osteoporosis. METHODS: In this double-blind, double-dummy trial, we enrolled post-menopausal women with at least two moderate or one severe vertebral fracture and a bone mineral density T score of less than or equal to -1·50. Participants were randomly assigned to receive 20 μg of teriparatide once daily plus oral weekly placebo or 35 mg of oral risedronate once weekly plus daily injections of placebo for 24 months...
November 9, 2017: Lancet
https://www.readbyqxmd.com/read/29126600/effect-of-treatment-delay-on-the-effectiveness-and-safety-of-antifibrinolytics-in-acute-severe-haemorrhage-a-meta-analysis-of-individual-patient-level-data-from-40%C3%A2-138-bleeding-patients
#14
Angèle Gayet-Ageron, David Prieto-Merino, Katharine Ker, Haleema Shakur, François-Xavier Ageron, Ian Roberts
BACKGROUND: Antifibrinolytics reduce death from bleeding in trauma and post-partum haemorrhage. We examined the effect of treatment delay on the effectiveness of antifibrinolytics. METHODS: We did an individual patient-level data meta-analysis of randomised trials done with more than 1000 patients that assessed antifibrinolytics in acute severe bleeding. We identified trials done between Jan 1, 1946, and April 7, 2017, from MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, PubMed, Popline, and the WHO International Clinical Trials Registry Platform...
November 7, 2017: Lancet
https://www.readbyqxmd.com/read/29123860/diagnostic-accuracy-of-radiographs-for-detecting-supraglottitis-a-systematic-review-and-meta-analysis
#15
Takashi Fujiwara, Toyohisa Miyata, Hironobu Tokumasu, Hiroko Gemba, Toshio Fukuoka
Aim: To assess the diagnostic performance of lateral radiograph of the neck for supraglottitis in adults and children. Methods: Electronic database searches (including PubMed, EMBASE, CINAHL, Web of Science, and WHO International Clinical Trials Registry Platform) were carried out through July 2014. Citations of included studies and recent narrative reviews were searched. Studies that compared lateral radiograph of the neck with a reference standard of direct/indirect laryngoscopy were included...
April 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122596/studies-of-lysine-cyclodeaminase-from-streptomyces-pristinaespiralis-insights-into-the-complex-transition-nad-state
#16
Hanxiao Ying, Jing Wang, Ting Shi, Yilei Zhao, Xin Wang, Pingkai Ouyang, Kequan Chen
Lysine cyclodeaminase (LCD) catalyzes the piperidine ring formation in macrolide-pipecolate natural products metabolic pathways from a lysine substrate through a combination of cyclization and deamination. This enzyme belongs to a unique enzyme class, which uses NAD(+) as the catalytic prosthetic group instead of as the co-substrate. To understand the molecular details of NAD(+) functions in lysine cyclodeaminase, we have determined four ternary crystal structure complexes of LCD-NAD(+) with pipecolic acid (LCD-PA), lysine (LCD-LYS), and an intermediate (LCD-INT) as ligands at 2...
November 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29120600/recoil-effect-and-photoemission-splitting-of-trions-in-monolayer-mos2
#17
Qicheng Zhang, Carl H Naylor, Zhaoli Gao, Ruizhe Wu, Irfan Haider Abidi, Meng-Qiang Zhao, Yao Ding, Aldrine Abenoja Cagang, Minghao Zhuang, Xuewu Ou, Zhengtang Luo
The 2D geometry nature and low dielectric constant in transition-metal dichalcogenides lead to easily formed strongly bound excitons and trions. Here, we studied the photoluminescence of van der Waals heterostructures of monolayer MoS2 and graphene at room temperature and observed two photoluminescence peaks that are associated with trion emission. Further study of different heterostructure configurations confirms that these two peaks are intrinsic to MoS2 and originate from a bound state and Fermi level, respectively, of which both accept recoiled electrons from trion recombination...
November 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/29120523/a-magic-ratio-rule-for-beginners-a-chemist-s-guide-to-quantum-interference-in-molecules
#18
Colin J Lambert, Shi-Xia Liu
This overview will give a glimpse into chemical design principles for gating quantum interference (QI) effects in molecular-scale devices. Direct observation of room temperature QI in single-molecule junctions has stimulated growing interest in fabrication of tailor-made molecular electronic devices. Herein, we outline a new conceptual advance in the scientific understanding and technological know-how necessary to control QI effects in single molecules by chemical modification. We start by discussing QI from a chemical viewpoint and then describe a new magic ratio rule (MRR), which captures a minimal description of connectivity-driven charge transport and provides a useful starting point for chemists to design appropriate molecules for molecular electronics with desired functions...
November 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29118219/nonhuman-primate-optogenetics-recent-advances-and-future-directions
#19
Adriana Galvan, William R Stauffer, Leah Acker, Yasmine El-Shamayleh, Ken-Ichi Inoue, Shay Ohayon, Michael C Schmid
Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity. By targeting opsin expression to specific cell types and neuronal pathways, optogenetics can expand our understanding of the neural basis of normal and pathological behavior. To maximize the potential of optogenetics to study human cognition and behavior, optogenetics should be applied to the study of nonhuman primates (NHPs). The homology between NHPs and humans makes these animals the best experimental model for understanding human brain function and dysfunction...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29115566/downregulation-of-microrna%C3%A2-155-by-preoperative-administration-of-valproic-acid-prevents-postoperative-seizures-by-upregulating-scn1a
#20
Zhijie Zhang, Zhenzhong Wang, Bo Zhang, Yan Liu
The risk of seizure is increased following brain surgery such as cranioplasty. Patients with seizures that are treated with valproic acid (VPA) may have a decreased risk of further seizures. To verify microRNA (miR)‑155 as a potential biomarker for the occurrence of seizures, reverse transcription quantitative polymerase chain reaction (RT‑qPCR) was used. Computational analysis and luciferase reporter assay was performed to identify the putative target of miR‑155. RT‑qPCR and western blot analyses were used to determine the expression level of miR‑155, sodium voltage‑gated channel α subunit 1 (SCN1A) mRNA and protein...
November 7, 2017: Molecular Medicine Reports
keyword
keyword
20576
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"