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https://www.readbyqxmd.com/read/29331425/low-picomolar-label-free-procalcitonin-analytical-detection-with-an-electrolyte-gated-organic-field-effect-transistor-based-electronic-immunosensor
#1
Preethi Seshadri, Kyriaki Manoli, Nicole Schneiderhan-Marra, Uwe Anthes, Piotr Wierzchowiec, Klaus Bonrad, Cinzia Di Franco, Luisa Torsi
Herein a label-free immunosensor based on electrolyte-gated organic field-effect transistor (EGOFET) was developed for the detection of procalcitonin (PCT), a sepsis marker. Antibodies specific to PCT were immobilized on the poly-3-hexylthiophene (P3HT) organic semiconductor surface through direct physical adsorption followed by a post-treatment with bovine serum albumin (BSA) which served as the blocking agent to prevent non-specific adsorption. Antibodies together with BSA (forming the whole biorecognition layer) served to selectively capture the procalcitonin target analyte...
December 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29330525/distinct-modulation-of-inactivation-by-a-residue-in-the-pore-domain-of-voltage-gated-na-channels-mechanistic-insights-from-recent-crystal-structures
#2
Rene Cervenka, Peter Lukacs, Vaibhavkumar S Gawali, Song Ke, Xaver Koenig, Lena Rubi, Touran Zarrabi, Karlheinz Hilber, Walter Sandtner, Anna Stary-Weinzinger, Hannes Todt
Inactivation of voltage-gated Na+ channels (VGSC) is essential for the regulation of cellular excitability. The molecular rearrangement underlying inactivation is thought to involve the intracellular linker between domains III and IV serving as inactivation lid, the receptor for the lid (domain III S4-S5 linker) and the pore-lining S6 segements. To better understand the role of the domain IV S6 segment in inactivation we performed a cysteine scanning mutagenesis of this region in rNav 1.4 channels and screened the constructs for perturbations in the voltage-dependence of steady state inactivation...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330065/stargazin-differentially-modulates-ampakine-gating-kinetics-and-pharmacology
#3
Daniel P Radin, Yong-Xin Li, Gary Rogers, Richard Purcell, Arnold Lippa
It was previously reported that Stargazin (STG) enhances the surface expression of AMPA receptors, controls receptor gating and slows channel desensitization as an auxiliary subunit of the receptors. Ampakines are a class of AMPA receptor positive allosteric modulators that modify rates of transmitter binding, channel activity and desensitization parameters. As such, they have shown efficacy in animal models of neurodegenerative diseases, where excitatory synaptic transmission is compromised. Given the functional similarities between STG and ampakines, the current study sought to probe interactions between STG and ampakine gating properties...
January 9, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29328731/high-resolution-quantum-sensing-with-shaped-control-pulses
#4
J Zopes, K Sasaki, K S Cujia, J M Boss, K Chang, T F Segawa, K M Itoh, C L Degen
We investigate the application of amplitude-shaped control pulses for enhancing the time and frequency resolution of multipulse quantum sensing sequences. Using the electronic spin of a single nitrogen-vacancy center in diamond and up to 10 000 coherent microwave pulses with a cosine square envelope, we demonstrate 0.6-ps timing resolution for the interpulse delay. This represents a refinement by over 3 orders of magnitude compared to the 2-ns hardware sampling. We apply the method for the detection of external ac magnetic fields and nuclear magnetic resonance signals of ^{13}C spins with high spectral resolution...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328625/double-channel-piezotronic-transistors-for-highly-sensitive-pressure-sensing
#5
Shuhai Liu, Longfei Wang, Zheng Wang, Yafeng Cai, Xiaolong Feng, Yong Qin, Zhong Lin Wang
Piezotronic transistor (PT) that utilize inner crystal potential generated by interface piezoelectric polarization charges as the gate voltage has great potential applications in force/pressure triggered or controlled electronics device, sensors, human-machine communication and microelectromechanical systems. Although the performance of PTs has been partly enhanced by exploring special materials with different geometry or high piezoelectricity, few studies have been focused on the structure design of PT itself to more effectively enhance the performance and structural reliability...
January 12, 2018: ACS Nano
https://www.readbyqxmd.com/read/29328278/controlled-phase-manipulation-module-for-orbital-angular-momentum-photon-states
#6
Fang-Xiang Wang, Juan Wu, Wei Chen, Zhen-Qiang Yin, Shuang Wang, Guang-Can Guo, Zheng-Fu Han
Phase manipulation is essential to quantum information processing, for which the orbital angular momentum (OAM) of photon is a promising high-dimensional resource. Dove prism (DP) is one of the most important elements to realize the nondestructive phase manipulation of OAM photons. DP usually changes the polarization of light and thus increases the manipulation error for a spin-OAM hybrid state. DP in a Sagnac interferometer also introduces a mode-dependent global phase to the OAM mode. In this work, we implemented a high-dimensional controlled-phase manipulation module (PMM), which can compensate the mode-dependent global phase and thus preserve the phase in the spin-OAM hybrid superposition state...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29326171/abdominal-vagal-afferents-modulate-the-brain-transcriptome-and-behaviors-relevant-to-schizophrenia
#7
Melanie Klarer, Jean-Philippe Krieger, Juliet Richetto, Ulrike Weber-Stadlbauer, Lydia Günther, Christine Winter, Myrtha Arnold, Wolfgang Langhans, Urs Meyer
Reduced activity of vagal efferents has long been implicated in schizophrenia and appears to be responsible for diminished parasympathetic activity and associated peripheral symptoms such as low heart rate variability and cardiovascular complications in affected individuals. In contrast, only little attention has been paid to the possibility that impaired afferent vagal signaling may be relevant for the disorder's pathophysiology as well. The present study explored this hypothesis using a model of subdiaphragmatic vagal deafferentation (SDA) in male rats...
January 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29326133/lipid-signaling-to-membrane-proteins-from-second-messengers-to-membrane-domains-and-adapter-free-endocytosis
#8
REVIEW
Donald W Hilgemann, Gucan Dai, Anthony Collins, Vincenzo Lariccia, Simona Magi, Christine Deisl, Michael Fine
Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein-membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable Journal of General Physiology publications that have contributed to our present understanding...
January 11, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29325855/gating-of-long-term-potentiation-ltp-in-the-thalamocortical-auditory-system-of-rats-by-serotonergic-5-ht-receptors
#9
Karen K Y Lee, Chloe N Soutar, Hans C Dringenberg
The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) plays an important role in controlling the induction threshold and maintenance of long-term potentiation (LTP) in the visual cortex and hippocampus of rodents. Serotonergic fibers also innervate the rodent primary auditory cortex (A1), but the regulation of A1 plasticity by 5-HT receptors (5-HTRs) is largely uncharted. Thus, we examined the role of several, predominant 5-HT receptor classes (5-HT1ARs, 5-HT2Rs, and 5-HT3Rs) in gating in vivo LTP induction at A1 synapses of adult, urethane-anesthetized rats...
January 8, 2018: Brain Research
https://www.readbyqxmd.com/read/29324848/platelet-rich-plasma-to-treat-experimentally-induced-skin-wounds-in-animals-a-systematic-review-and-meta-analysis
#10
Adolfo Maria Tambella, Anna Rita Attili, Gilles Dupré, Andrea Cantalamessa, Stefano Martin, Vincenzo Cuteri, Sabrina Marcazzan, Massimo Del Fabbro
The objective of the study was to review current literature to determine whether the topical application of platelet-rich plasma (PRP) promotes healing in experimentally-induced full-thickness skin wounds in animals. The hypothesis was that the adjunct of PRP has a positive effect on wound healing. An electronic search was carried out on the following databases: Web of Science, Cochrane Library, PubMed, Research Gate, Cochrane Wounds Group, Veterinary Information Network. No publication date nor language restrictions were applied...
2018: PloS One
https://www.readbyqxmd.com/read/29321139/bmp-smad-pathway-promotes-neurogenesis-of-midbrain-dopaminergic-neurons-in-vivo-and-in-human-induced-pluripotent-and-neural-stem-cells
#11
V M Jovanovic, A Salti, H Tilleman, K Zega, M M Jukic, H Zou, R H Friedel, N Prakash, S Blaess, F Edenhofer, C Brodski
The embryonic formation of midbrain dopaminergic (mDA) neurons in vivo provides critical guidelines for the in vitro differentiation of mDA neurons from stem cells, currently being developed for Parkinson's disease cell replacement therapy. Bone morphogenetic protein (BMP)/SMAD inhibition is routinely used during early steps of stem cell differentiation protocols, including for the generation of mDA neurons. However, the function of the BMP/SMAD pathway for in vivo specification of mammalian mDA neurons is virtually unknown...
January 10, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29320741/endocytosis-of-katp-channels-drives-glucose-stimulated-excitation-of-pancreatic-%C3%AE-cells
#12
Young-Eun Han, Jung Nyeo Chun, Min Jeong Kwon, Young-Sun Ji, Myong-Ho Jeong, Hye-Hyun Kim, Sun-Hyun Park, Jong Cheol Rah, Jong-Sun Kang, Suk-Ho Lee, Won-Kyung Ho
Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depends on the inhibition of KATP channel activity in HG. It is generally believed that HG-induced effects are mediated by the increase in intracellular ATP, but here, we showed that, in INS-1 cells, endocytosis of KATP channel plays a major role. Upon HG stimulation, resting membrane potential depolarized by 30.6 mV (from -69.2 to -38.6 mV) and KATP conductance decreased by 91% (from 0.243 to 0.022 nS/pF), whereas intracellular ATP was increased by only 47%...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29319611/comparison-of-somatosensory-cortex-excitability-between-migraine-and-strict-criteria-tension-type-headache-a-magnetoencephalographic-study
#13
Wei-Ta Chen, Fu-Jung Hsiao, Yu-Chieh Ko, Hung-Yu Liu, Pei-Ning Wang, Jong-Ling Fuh, Yung-Yang Lin, Shuu-Jiun Wang
Tension-type headache (TTH) and migraine are both common types of headaches. Despite distinct symptoms, TTH and migraine are highly comorbid and exhibit many clinical similarities. This study enrolled consecutive patients with TTH and age- and sex-matched patients with migraine and healthy controls to investigate whether TTH and migraine are similar in brain excitability change assessed by magnetoencephalography. Patients with TTH were excluded if they reported any headache features or associated symptoms of migraine...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29318679/magnetic-induced-piezopotential-gated-mos2-field-effect-transistor-at-room-temperature
#14
Yudong Liu, Junmeng Guo, Aifang Yu, Yang Zhang, Jinzong Kou, Ke Zhang, Rongmei Wen, Yan Zhang, Junyi Zhai, Zhong Lin Wang
Utilizing magnetic field directly modulating/turning the charge carrier transport behavior of field-effect transistor (FET) at ambient conditions is an enormous challenge in the field of micro-nanoelectronics. Here, a new type of magnetic-induced-piezopotential gated field-effect-transistor (MIPG-FET) base on laminate composites is proposed, which consists of Terfenol-D, a ferroelectric single crystal (PMNPT), and MoS2 flake. When applying an external magnetic field to the MIPG-FET, the piezopotential of PMNPT triggered by magnetostriction of the Terfenol-D can serve as the gate voltage to effectively modulate/control the carrier transport process and the corresponding drain current at room temperature...
January 10, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29317246/presynaptic-calcium-channels
#15
REVIEW
Sumiko Mochida
At the presynaptic terminal, neuronal firing activity induces membrane depolarization and subsequent Ca2+ entry through voltage-gated Ca2+ (CaV) channels triggers neurotransmitter release from the active zone. Presynaptic Ca2+ channels form a large signaling complex, which targets synaptic vesicles to Ca2+ channels for efficient release and mediates Ca2+ channel regulation. The presynaptic CaV2 channel family (comprising CaV2.1, CaV2.2 and CaV2.3 isoforms) encode the pore-forming α1 subunit. The cytoplasmic regions are the target of regulatory proteins for channel modulation...
January 6, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29316178/evaluation-of-cd229-as-a-new-alternative-plasma-cell-gating-marker-in-the-flow-cytometric-immunophenotyping-of-monoclonal-gammopathies
#16
Prashant R Tembhare, Sitaram Ghogale, Wilma Tauro, Yajamanam Badrinath, Nilesh Deshpande, Shweta Kedia, Keziah Cherian, Nikhil V Patkar, Gaurav Chatterjee, Sumeet Gujral, Papagudi G Subramanian
BACKGROUND: Current flow-cytometric plasma cell (PC) gating is based on CD138, CD38 and CD45 expression. CD138 is known for variable expression and loss during storage and processing. Introduction of anti-CD38 and anti-CD138 monoclonal-antibody therapies has limited the use of these markers during follow-up. Hence, additional reliable PC-gating markers are required. Recently, CD229 has been claimed as an alternative PC-gating marker. However, these studies are limited to a small cohort of samples...
January 9, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29315402/cardiac-optogenetics-the-next-frontier
#17
Amit Gruber, Oded Edri, Lior Gepstein
The emerging technology of optogenetics uses optical and genetic means to monitor and modulate the electrophysiological properties of excitable tissues. While transforming the field of neuroscience, the technology has recently gained popularity also in the cardiac arena. Here, we describe the basic principles of optogenetics, the available and evolving optogenetic tools, and the unique potential of this technology for basic and translational cardiac electrophysiology. Specifically, we discuss the ability to control (augment or suppress) the cardiac tissue's excitable properties using optogenetic actuators (microbial opsins), which are light-gated ion channels and pumps that can cause light-triggered membrane depolarization or hyperpolarization...
January 5, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29314772/the-contribution-of-executive-control-to-semantic-cognition-convergent-evidence-from-semantic-aphasia-and-executive-dysfunction
#18
Hannah E Thompson, Azizah Almaghyuli, Krist A Noonan, Ohr Barak, Matthew A Lambon Ralph, Elizabeth Jefferies
Semantic cognition, as described by the controlled semantic cognition (CSC) framework (Rogers et al., , Neuropsychologia, 76, 220), involves two key components: activation of coherent, generalizable concepts within a heteromodal 'hub' in combination with modality-specific features (spokes), and a constraining mechanism that manipulates and gates this knowledge to generate time- and task-appropriate behaviour. Executive-semantic goal representations, largely supported by executive regions such as frontal and parietal cortex, are thought to allow the generation of non-dominant aspects of knowledge when these are appropriate for the task or context...
January 3, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29314714/behavioral-fragmentation-in-the-d1ct-7-mouse-model-of-tourette-s-syndrome
#19
Andrea Santangelo, Marco Bortolato, Laura J Mosher, Giuseppe Crescimanno, Giuseppe Di Giovanni, Emanuele Cassioli, Valdo Ricca, Maurizio Casarrubea
AIM: The transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS. METHODS: The behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed...
January 3, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29313492/rufinamide-for-the-treatment-of-lennox-gastaut-syndrome-evidence-from-clinical-trials-and-clinical-practice
#20
Pasquale Striano, Rob McMurray, Estevo Santamarina, Mercè Falip
Rufinamide was granted orphan drug status in 2004 for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in patients aged ≥4 years, and was subsequently approved for this indication in several countries, including Europe and the United States. Structurally unrelated to other antiepileptic drugs, rufinamide is thought to act primarily by prolonging the inactivation phase of voltage-gated sodium channels. Rufinamide was approved on the basis of an international, randomised, placebo-controlled Phase III trial, conducted in 138 patients with Lennox-Gastaut syndrome, which demonstrated its favourable tolerability profile and efficacy in significantly reducing the frequency of drop attacks and total seizures, compared with placebo...
January 9, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
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