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https://www.readbyqxmd.com/read/28630253/cold-induced-thermogenesis-and-inflammation-associated-cold-seeking-behavior-are-represented-by-different-dorsomedial-hypothalamic-sites-a-three-dimensional-functional-topography-study-in-conscious-rats
#1
Samuel P Wanner, M Camila Almeida, Yury P Shimansky, Daniela L Oliveira, Justin R Eales, Cândido C Coimbra, Andrej A Romanovsky
In the past, we showed that large electrolytic lesions of the dorsomedial hypothalamus (DMH) promoted hypothermia in cold-exposed restrained rats, but attenuated hypothermia in rats challenged with a high dose of bacterial lipopolysaccharide (LPS) in a thermogradient apparatus. The goal of this study was to identify the thermoeffector mechanisms and DMH representation of the two phenomena and, hence, understand how the same lesion could produce two opposite effects on body temperature. We found that the permissive effect of large electrolytic DMH lesions on cold-induced hypothermia was due to suppressed thermogenesis...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28623762/cortisol-stress-response-in-post-traumatic-stress-disorder-panic-disorder-and-major-depressive-disorder-patients
#2
Susann Wichmann, Clemens Kirschbaum, Carsten Böhme, Katja Petrowski
BACKGROUND: Previous research has focussed extensively on the distinction of HPA-axis functioning between patient groups and healthy volunteers, with relatively little emphasis on a direct comparison of patient groups. The current study's aim was to analyse differences in the cortisol stress response as a function of primary diagnosis of panic disorder (PD), post-traumatic stress disorder (PTSD), and major depressive disorder (MDD). METHODS: A total of n=30 PD (mean age±SD: 36...
June 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28622552/fornix-microalterations-associated-with-early-trauma-in-panic-disorder
#3
Seung-Taek Yu, Kang-Soo Lee, Sang-Hyuk Lee
BACKGROUND: It is well accepted that panic disorder (PD) is associated with early trauma, and that the limbic systems are one of the main structures involved in PD pathophysiology. However, previous studies have not addressed the relationship between early trauma and major limbic white-matter (WM) structures in PD. METHODS: Participants enrolled in the study consisted of 53 right-handed patients with PD and 21 healthy controls (HC). The Early Trauma Inventory Self Report-Short Form (ETISR-SF), Anxiety Sensitivity Inventory-Revised (ASI-R), and the Albany Panic and Phobia Questionnaire (APPQ) were applied in the study...
May 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28622039/determinants-for-craniofacial-pains-in-children-6-8-years-of-age-the-panic-study
#4
Anu Vierola, Anna Liisa Suominen, Aino-Maija Eloranta, Niina Lintu, Tiina Ikävalko, Matti Närhi, Timo A Lakka
OBJECTIVE: Determinants for orofacial pain, headache, morning headache and painful signs of temporomandibular disorders (TMD) were investigated in prepubertal children. MATERIAL AND METHODS: The participants were a population sample of 439 children aged 6-8 years. Craniofacial pains, eating meals and snacks, sleep bruxism, sleep quality, sleep-disordered breathing (SDB), psychological well-being, parental education and household income were assessed by questionnaires filled out by the parents...
June 16, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28619227/efficacy-and-safety-of-praziquantel-in-preschool-aged-and-school-aged-children-infected-with-schistosoma-mansoni-a-randomised-controlled-parallel-group-dose-ranging-phase-2-trial
#5
Jean T Coulibaly, Gordana Panic, Kigbafori D Silué, Jana Kovač, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Praziquantel has been the drug of choice for schistosomiasis control for more than 40 years, yet surprisingly, the optimal dose for children younger than 4 years is not known. We aimed to assess the efficacy and safety of escalating praziquantel dosages in preschool-aged children (PSAC). METHODS: We did a randomised controlled, parallel-group, single-blind, dose-ranging, phase 2 trial in PSAC (2-5 years) and school-aged children (SAC; aged 6-15 years) as a comparator group in southern Côte d'Ivoire...
July 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28617392/-panic-disorder-clinical-phenomena-and-treatment-options
#6
Yu P Sivolap
Panic disorder is a common mental disease with high psychiatric comorbidity. It is considered that a combination of genetic predisposition and a special psychic vulnerability plays a key role in the occurrence of panic disorder. Clinically proven efficacy in the treatment of panic disorder have benzodiazepines, tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors; antidepressants from other pharmaceutical groups are also used...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28615769/gender-life-events-and-depression-an-exploratory-study
#7
Subahani Shaik, Ravi Philip Rajkumar, Vikas Menon, Siddharth Sarkar
CONTEXT: Literature is inconsistent about the role of gender in mediating the relationship between life events and depression. AIM: Our objective was to explore gender differences in patterns and frequencies of stressful life events before onset of a depressive episode. SETTING AND DESIGN: Cross-sectional study at a tertiary care center. SUBJECTS AND METHODS: One hundred patients fulfilling Diagnostic and Statistical Manual of Mental Disorders fourth edition criteria for current major depression (50 males and 50 females) were recruited for the study...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28614176/correlation-between-cytochrome-p450-2c19-genetic-polymorphism-and-treatment-response-to-escitalopram-in-panic-disorder
#8
Qianqian He, Zhuo Yuan, Yuanyuan Liu, Jian Zhang, Hong Yan, Li Shen, Xingguang Luo, Yong Zhang
OBJECTIVES: Escitalopram (S-CT) is used widely to treat patients with panic disorder (PD) and the CYP2C19 enzyme is responsible for S-CT metabolism. We hypothesized that CYP2C19 polymorphisms were associated with S-CT treatment response in Chinese patients with PD. PATIENTS AND METHODS: Seventy-eight patients with PD completed the assessment by the Panic Disorder Severity Scale - Chinese Version (PDSS-CV) and the Hamilton Anxiety Scale (HAMA-14) during an 8-week period...
June 13, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28613010/immobilized-monolithic-enzymatic-reactors-and-its-application-on-analysis-of-in-vitro-fertilization-media-samples
#9
Wei-Qiang Chen, Philipp Obermayr, Urh Černigoj, Jana Vidič, Tanja Panić-Janković, Goran Mitulović
Classical proteomics approaches involve enzymatic hydrolysis of proteins (either separated by polyacrylamide gels or in solution) followed by peptide identification using LC-MS/MS analysis. This method requires normally more than sixteen hours to complete. In the case of clinical analysis, it is of the utmost importance to provide fast and reproducible analysis with minimal manual sample handling. Herein we report the method development for online protein digestion on immobilized monolithic enzymatic reactors (IMER) to accelerate protein digestion, reduce manual sample handling, and provide reproducibility to the digestion process in clinical laboratory...
June 14, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28610672/agoraphobic-avoidance-predicts-emotional-distress-and-increased-physical-concerns-in-chronic-obstructive-pulmonary-disease
#10
Pawel Holas, Jaroslaw Michałowski, Łukasz Gawęda, Joanna Domagała-Kulawik
BACKGROUND: Anxiety and panic attacks are more common in chronic obstructive pulmonary disease (COPD) than in the overall population. Individuals with panic attacks often attempt to avoid situations perceived as at risk of eliciting bodily sensations such as dyspnea, which paradoxically may lead to anxiety-related responsivity. Although there is some evidence that COPD individuals restrict their participation in various life activities because they fear that these may trigger breathlessness, little is known about agoraphobic avoidance and its impact on cognitions and emotional distress in this population...
July 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28610592/xenon-in-the-treatment-of-panic-disorder-an-open-label-study
#11
Alexander Dobrovolsky, Thomas E Ichim, Daqing Ma, Santosh Kesari, Vladimir Bogin
BACKGROUND: Current treatments of panic disorder (PD) are limited by adverse effects, poor efficacy, and need for chronic administration. The established safety profile of subanesthetic concentrations of xenon gas, which is known to act as a glutamate subtype NMDA receptor antagonist, coupled with preclinical studies demonstrating its effects in other anxiety related conditions, prompted us to evaluate its feasibility and efficacy in treatment of patients with PD. METHODS: An open-label clinical trial of xenon-oxygen mixture was conducted in 81 patients with PD; group 1 consisting of patients only with PD (N = 42); and group 2 patients with PD and other comorbidities (N = 39)...
June 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28609311/gender-differences-of-stressful-life-events-coping-style-symptom-severity-and-health-related-quality-of-life-in-patients-with-panic-disorder
#12
Ji Eun Kim, In Han Song, Sang-Hyuk Lee
Although affective disorders have been known to have sex differences in the associated clinical characteristics and quality of life (QOL), sex differences among patients with panic disorder (PD) have remained relatively unexplored in Korea. We examined the sex differences in different types of stressful life events (SLEs), coping styles, symptom severity, and health-related QOL (HRQOL) in patients with PD. Data from 291 female and 254 male participants diagnosed with PD were analyzed using a structured clinical interview following the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria...
June 12, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28609307/a-6-year-posttreatment-follow-up-of-panic-disorder-patients-treatment-with-clonazepam-predicts-lower-recurrence-than-treatment-with-paroxetine
#13
Rafael C Freire, Roman Amrein, Marina D Mochcovitch, Gisele P Dias, Sergio Machado, Marcio Versiani, Oscar Arias-Carrión, Mauro G Carta, Antonio E Nardi
BACKGROUND: The aim of this study was to identify factors associated with relapse in panic disorder (PD). METHODS: This was an observational study conducted in the outpatient clinic of a psychiatric hospital in Rio de Janeiro, Brazil. In a previous study, 120 patients diagnosed as having PD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria were randomized to receive clonazepam or paroxetine. After 3 years, treatment was discontinued in patients who had achieved remission...
June 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28608575/association-between-comt-val158met-and-psychiatric-disorders-a-comprehensive-meta-analysis
#14
Steven Taylor
Catechol-O-methyltransferase (COMT) Val158Met is widely regarded as potentially important for understanding the genetic etiology of many different psychiatric disorders. The present study appears to be the first comprehensive meta-analysis of COMT genetic association studies to cover all psychiatric disorders for which there were available data, published in any language, and with an emphasis on investigating disorder subtypes (defined clinically or by demographic or other variables). Studies were included if they reported one or more datasets (i...
June 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28606869/predicting-mental-conditions-based-on-history-of-present-illness-in-psychiatric-notes-with-deep-neural-networks
#15
Tung Tran, Ramakanth Kavuluru
BACKGROUND: Applications of natural language processing to mental health notes are not common given the sensitive nature of the associated narratives. The CEGS N-GRID 2016 Shared Task in Clinical Natural Language Processing (NLP) changed this scenario by providing the first set of neuropsychiatric notes to participants. This study summarizes our efforts and results in proposing a novel data use case for this dataset as part of the third track in this shared task. OBJECTIVE: We explore the feasibility and effectiveness of predicting a set of common mental conditions a patient has based on the short textual description of patient's history of present illness typically occurring in the beginning of a psychiatric initial evaluation note...
June 9, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28601869/rejoinder-to-commentary-panic-self-disorder-and-ease-research-methodological-considerations
#16
Luís Madeira, Sergio Carmenates, Cristina Costa, Ludgero Linhares, Giovanni Stanghellini, Maria Luísa Figueira, Louis Sass
No abstract text is available yet for this article.
June 10, 2017: Psychopathology
https://www.readbyqxmd.com/read/28599192/psychophysiological-and-self-reported-reactivity-associated-with-social-anxiety-and-public-speaking-fear-symptoms-effects-of-fear-versus-distress
#17
Georgia Panayiotou, Maria Karekla, Dora Georgiou, Elena Constantinou, Michaela Paraskeva-Siamata
This study examines psychophysiological and subjective reactivity to anxiety-provoking situations in relation to social anxiety and public speaking fear. We hypothesized that social anxiety symptoms would be associated with similar reactivity across types of imaginary anxiety scenes and not specifically to social anxiety-related scenes. This would be attributed to co-existing depression symptoms. Public speaking fear was expected to be associated with more circumscribed reactivity to survival-threat scenes, due to its association with fearfulness...
June 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28598929/association-of-job-stressors-with-panic-attack-and-panic-disorder-in-a-working-population-in-japan-a-cross-sectional-study
#18
Yumi Asai, Kotaro Imamura, Norito Kawakami
OBJECTIVE: This study aimed to investigate associations of job stressors with panic attack (PA) and panic disorder (PD) among Japanese workers. METHODS: A cross-sectional online questionnaire survey was conducted of 2060 workers. Job strain, effort/reward imbalance, and workplace social support were measured by the job content questionnaire and effort/reward imbalance questionnaire. These variables were classified into tertiles. PA/PD were measured by self-report based on the mini international neuropsychiatric interview (MINI)...
June 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28596667/air-bubbles-produced-during-rapid-blood-warming-with-inline-blood-warmer-leading-to-panic-of-air-embolism
#19
Vijay Kumawat, Anil Aribandi
No abstract text is available yet for this article.
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28595115/the-weakest-link-as-an-indicator-of-cognitive-vulnerability-differentially-predicts-symptom-dimensions-of-anxiety-in-adolescents-in-china
#20
Junyi Wang, Danyang Wang, Lixia Cui, Chad M McWhinnie, Li Wang, Jing Xiao
This multiwave longitudinal study examined the cognitive vulnerability-stress component of hopelessness theory to differentially predict symptom dimensions of anxiety using a "weakest link" approach in a sample of adolescents from Hunan Province, China. Baseline and 6-month follow-up data were obtained from 553 middle-school students. During an initial assessment, participants completed measures of assessing their weakest links, anxious symptoms, and the occurrence of stress. Participants subsequently completed measures assessing stress, and anxious symptoms one a month for six months...
May 26, 2017: Journal of Anxiety Disorders
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