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https://www.readbyqxmd.com/read/28231495/drug-induced-panic-attacks-analysis-of-cases-registered-in-the-french-pharmacovigilance-database
#1
Delphine Abadie, Anaïs Essilini, Virginie Fulda, Aurore Gouraud, Mélissa Yéléhé-Okouma, Joëlle Micallef, François Montastruc, Jean Louis Montastruc
BACKGROUND: The potential role of drugs in the onset of panic attacks (PAs) is poorly understood. AIM: The objective of our study was to characterize drug-induced PAs. METHOD: We performed an analysis of PAs registered in the French pharmacovigilance database between 01/01/1985 and 05/11/2014. RESULTS: Among the 163 recorded cases, 136 (83.4%) were directly related to drugs, mainly antidepressants (11.3%, mainly serotonin reuptake inhibitors), mefloquine (7...
February 9, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28230390/effectiveness-of-an-internet-intervention-deprexis-for-depression-in-a-united-states-adult-sample-a-parallel-group-pragmatic-randomized-controlled-trial
#2
Christopher G Beevers, Rahel Pearson, James S Hoffman, A Alban Foulser, Jason Shumake, Björn Meyer
OBJECTIVE: To examine the effectiveness of an Internet intervention for depression with a randomized, controlled trial in a large sample of adults recruited from the United States. METHOD: The current study examines the effectiveness of Deprexis, an Internet treatment for depression that was provided with relatively minimal support. There were 376 treatment-seeking adults (mean age = 32 years; 74% female; 77% Caucasian, 7% Asian, 7% multiple races, 4% African American, and 11% Hispanic/Latino) with elevated depression (Quick Inventory of Depressive Symptoms-Self-Report [QIDS-SR] > = 10) who were randomized to receive an 8-week course of treatment immediately (n = 285) or after an 8-week delay (n = 91; i...
February 23, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28229356/symptoms-of-swallowing-anxiety-in-panic-disorder-patients-and-associated-psychopathologic-factors
#3
Ersin Budak, İbrahim Taymur, Sinay Önen, Bilgen Biçer Kanat, Önder Akdeniz, Hakan Demirci
AIM: The aim of this study was to investigate symptoms of swallowing difficulty in Panic Disorder (PD) patients and the factors associated with these symptoms. METHODS: In the pre-phase of the study, 22 PD patients who were treated in psychiatry outpatient clinics and who were found to have swallowing difficulty were evaluated. PD patients were asked to write about their thoughts, feelings and behaviors associated with swallowing difficulty. Later, these texts were examined and 41 expressions were identified in which patients described their swallowing difficulty...
February 22, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28225509/psychometric-properties-of-the-reconstructed-hamilton-depression-and-anxiety-scales
#4
Eliora Porter, Dianne L Chambless, Kevin S McCarthy, Robert J DeRubeis, Brian A Sharpless, Marna S Barrett, Barbara Milrod, Steven D Hollon, Jacques P Barber
Although widely used, the Hamilton Rating Scale for Depression (HRSD) and Hamilton Anxiety Rating Scale (HARS) discriminate poorly between depression and anxiety. To address this problem, Riskind, Beck, Brown, and Steer (J Nerv Ment Dis. 175:474-479, 1987) created the Reconstructed Hamilton Scales by reconfiguring HRSD and HARS items into modified scales. To further analyze the reconstructed scales, we examined their factor structure and criterion-related validity in a sample of patients with major depressive disorder and no comorbid anxiety disorders (n = 215) or with panic disorder and no comorbid mood disorders (n = 149)...
February 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28223243/on-the-verge-of-a-respiratory-type-panic-attack-selective-activations-of-rostrolateral-and-caudoventrolateral-periaqueductal-gray-matter-following-short-lasting-escape-to-a-low-dose-of-potassium-cyanide
#5
Cláudia Janaina Torres Müller, Jeyce Willig Quintino-Dos-Santos, Fagna Giacomin Schimitel, Sérgio Tufik, Vanessa Beijamini, Newton Sabino Canteras, Luiz Carlos Schenberg
Intravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO2, it is suppressed by both lesions of PAG and clinically-effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxia-sensitive alarm system which activation could both precipitate panic and render the subject hypersensitive to CO2. Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (>60 µg) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior...
February 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28220872/human-enterovirus-71-protein-interaction-network-prompts-antiviral-drug-repositioning
#6
Lu Han, Kang Li, Chaozhi Jin, Jian Wang, Qingjun Li, Qiling Zhang, Qiyue Cheng, Jing Yang, Xiaochen Bo, Shengqi Wang
As a predominant cause of human hand, foot, and mouth disease, enterovirus 71 (EV71) infection may lead to serious diseases and result in severe consequences that threaten public health and cause widespread panic. Although the systematic identification of physical interactions between viral proteins and host proteins provides initial information for the recognition of the cellular mechanism involved in viral infection and the development of new therapies, EV71-host protein interactions have not been explored...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216786/clinical-practice-guidelines-for-the-management-of-generalised-anxiety-disorder-gad-and-panic-disorder-pd
#7
Shiv Gautam, Akhilesh Jain, Manaswi Gautam, Vihang N Vahia, Anita Gautam
No abstract text is available yet for this article.
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28215269/is-there-an-association-between-short-sleep-duration-and-adolescent-anxiety-disorders
#8
Robert E Roberts, Hao T Duong
OBJECTIVE: The purpose of this study is to provide the first data on the prospective, reciprocal association between short sleep duration and DSM-IV anxiety disorders among adolescents. METHODS: A community-based two-wave cohort study included 4175 youths aged 11-17 years at baseline, with 3134 of these followed up a year later, drawn from a metropolitan area with a population of over 4 million. Anxiety is defined as any DSM-IV anxiety disorder in the past year generalized anxiety: panic disorder, agoraphobia without panic, social phobia, and post-traumatic stress disorder...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28213340/demographic-and-indication-specific-characteristics-have-limited-association-with-social-network-engagement-evidence-from-24-954-members-of-four-health-care-support-groups
#9
Trevor van Mierlo, Xinlong Li, Douglas Hyatt, Andrew T Ching
BACKGROUND: Digital health social networks (DHSNs) are widespread, and the consensus is that they contribute to wellness by offering social support and knowledge sharing. The success of a DHSN is based on the number of participants and their consistent creation of externalities through the generation of new content. To promote network growth, it would be helpful to identify characteristics of superusers or actors who create value by generating positive network externalities. OBJECTIVE: The aim of the study was to investigate the feasibility of developing predictive models that identify potential superusers in real time...
February 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28209208/food-safety-in-vietnam-where-we-are-at-and-what-we-can-learn-from-international-experiences
#10
Hung Nguyen-Viet, Tran Thi Tuyet-Hanh, Fred Unger, Sinh Dang-Xuan, Delia Grace
Food-borne diseases are attracting a lot of attention in Vietnam as a result of repeated episodes of adulterated and unsafe food. In this paper, we provide some perspectives on food safety in Vietnam from the point of view of an international research institution working on food safety with partners in the country. We argue that one of the key issues of food safety in Vietnam is that certain food value chain stakeholders lack ethics, which leads to the production and trading of unsafe foods in order to make profits irrespective of adverse health effects on consumers...
February 16, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28194546/a-multisite-benchmarking-trial-of-capnometry-guided-respiratory-intervention-for-panic-disorder-in-naturalistic-treatment-settings
#11
David F Tolin, Patrick B McGrath, Lisa R Hale, Daniel N Weiner, Ralitza Gueorguieva
Panic disorder (PD) is associated with hyperventilation. The efficacy of a brief respiratory feedback program for PD has been established. The aim of the present study was to expand these results by testing a similar program with more clinically representative patients and settings. Sixty-nine adults with PD received 4 weeks of Capnometry Guided Respiratory Intervention (CGRI) using Freespira, which provides feedback of end-tidal CO2 (PETCO2) and respiration rate (RR), in four non-academic clinical settings...
February 13, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28188857/sensitivity-to-carbon-dioxide-and-translational-studies-of-anxiety-disorders
#12
Marco Battaglia
Heightened concentrations of CO2 in inhaled air provoke temporary acidification of the brain, followed by compensatory hyperventilation and increased arousal/anxiety. These responses are likely to map a basic, latent general alarm/avoidance system that is largely shared across mammals, and are sources of individual differences. By showing paroxysmal respiratory and emotional responses to CO2 challenges, humans with panic and separation anxiety disorders lie at one extreme of the distribution for CO2 sensitivity...
February 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28178858/technology-based-tools-and-services-for-people-with-dementia-and-carers-mapping-technology-onto-the-dementia-care-pathway
#13
Klara Lorenz, Paul P Freddolino, Adelina Comas-Herrera, Martin Knapp, Jacqueline Damant
The extent to which technology may be able to support people with dementia and their carers along the care pathway and in different care settings is of interest to policy makers and governments. In this paper we provide an overview of the role of technology in dementia care, treatment and support by mapping existing technologies - by function, target user and disease progression. Technologies identified are classified into seven functions: memory support, treatment, safety and security, training, care delivery, social interaction and other...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28177062/critical-neuropsychobiological-analysis-of-panic-attack-and-anticipatory-anxiety-like-behaviors-in-rodents-confronted-with-snakes-in-polygonal-arenas-and-complex-labyrinths-a-comparison-to-the-elevated-plus-and-t-maze-behavioral-tests
#14
Norberto C Coimbra, Tatiana Paschoalin-Maurin, Gabriel S Bassi, Alexandre Kanashiro, Audrey F Biagioni, Tatiana T Felippotti, Daoud H Elias-Filho, Joyce Mendes-Gomes, Jade P Cysne-Coimbra, Rafael C Almada, Bruno Lobão-Soares
Objective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors' research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined...
February 6, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28173886/comparison-of-the-dsm-5-and-icd-10-panic-and-other-anxiety-disorders
#15
Borwin Bandelow
Anxiety disorders are the most prevalent mental disorders and are associated with substantial healthcare costs and a high burden of disease. In this article, changes in the new Diagnostic and Statistical Manual for Mental Disorders (the DSM-5) with respect to panic disorder/agoraphobia, generalized anxiety disorder, social anxiety disorder, specific phobias, and selective mutism are compared with the International Classification of Diseases (ICD-10) system.
February 8, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28167838/glrb-allelic-variation-associated-with-agoraphobic-cognitions-increased-startle-response-and-fear-network-activation-a-potential-neurogenetic-pathway-to-panic-disorder
#16
J Deckert, H Weber, C Villmann, T B Lonsdorf, J Richter, M Andreatta, A Arias-Vasquez, L Hommers, L Kent, C Schartner, S Cichon, C Wolf, N Schaefer, C R von Collenberg, B Wachter, R Blum, D Schümann, R Scharfenort, J Schumacher, A J Forstner, C Baumann, M A Schiele, S Notzon, P Zwanzger, J G E Janzing, T Galesloot, L A Kiemeney, A Gajewska, E Glotzbach-Schoon, A Mühlberger, G Alpers, T Fydrich, L Fehm, A L Gerlach, T Kircher, T Lang, A Ströhle, V Arolt, H-U Wittchen, R Kalisch, C Büchel, A Hamm, M M Nöthen, M Romanos, K Domschke, P Pauli, A Reif
The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P=3...
February 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28166808/erratum-to-a-feasibility-study-of-the-clinical-effectiveness-and-cost-effectiveness-of-individual-cognitive-behavioral-therapy-for-panic-disorder-in-a-japanese-clinical-setting-an-uncontrolled-pilot-study
#17
Yoichi Seki, Shinobu Nagata, Takayuki Shibuya, Naoki Yoshinaga, Mizue Yokoo, Hanae Ibuki, Noriko Minamitani, Muga Kusunoki, Yasushi Inada, Nobuko Kawasoe, Soichiro Adachi, Kensuke Yoshimura, Michiko Nakazato, Masaomi Iyo, Akiko Nakagawa, Eiji Shimizu
No abstract text is available yet for this article.
February 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28164755/regulation-of-na-k-atpase-by-estradiol-and-igf-1-in-cardio-metabolic-diseases
#18
Milan Obradovic, Julijana Stanimirovic, Anastasija Panic, Nikola Bogdanovic, Emina Sudar-Milovanovic, Desanka Cenic-Milosevic, Esma R Isenovic
BACKGROUND: The sodium/potassium- adenosine- triphosphatase (Na+/K+-ATPase) is an important mediator in vasculature tone and contractility, and its abnormal regulation has been implicated in many diseases such as obesity, insulin resistance, diabetes, and hypertension. Decreased Na+/K+-ATPase abundance and its altered isoform expression induce cardiomyocytes death and cardiac dysfunction, possibly leading to the development of myocardial dilation and heart failure. Therefore, the regulation of Na+/K+-ATPase activity/expression could be important in treatment and possible prevention of cardio-metabolic diseases...
February 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28163133/how-many-blinks-are-necessary-for-a-reliable-startle-response-a-test-using-the-npu-threat-task
#19
Lynne Lieberman, Elizabeth S Stevens, Carter J Funkhouser, Anna Weinberg, Casey Sarapas, Ashley A Huggins, Stewart A Shankman
Emotion-modulated startle is a frequently used method in affective science. Although there is a growing literature on the reliability of this measure, it is presently unclear how many startle responses are necessary to obtain a reliable signal. The present study therefore evaluated the reliability of startle responding as a function of number of startle responses (NoS) during a widely used threat-of-shock paradigm, the NPU-threat task, in a clinical (N=205) and non-clinical (N=92) sample. In the clinical sample, internal consistency was also examined independently for healthy controls vs...
February 2, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28163046/temporal-stability-of-multiple-response-systems-to-7-5-carbon-dioxide-challenge
#20
Roxann Roberson-Nay, Eugenia I Gorlin, Jessica R Beadel, Therese Cash, Scott Vrana, Bethany A Teachman
Self-reported anxiety, and potentially physiological response, to maintained inhalation of carbon dioxide (CO2) enriched air shows promise as a putative marker of panic reactivity and vulnerability. Temporal stability of response systems during low-dose, steady-state CO2 breathing challenge is lacking. Outcomes on multiple levels were measured two times, one week apart, in 93 individuals. Stability was highest during the CO2 breathing phase compared to pre-CO2 and recovery phases, with anxiety ratings, respiratory rate, skin conductance level, and heart rate demonstrating good to excellent temporal stability (ICCs≥0...
February 2, 2017: Biological Psychology
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