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https://www.readbyqxmd.com/read/28445152/multiplexed-gene-expression-profiling-identifies-the-fgfr4-pathway-as-a-novel-biomarker-in-intrahepatic-cholangiocarcinoma
#1
Changhoon Yoo, Jihoon Kang, Deokhoon Kim, Kyu-Pyo Kim, Baek-Yeol Ryoo, Seung-Mo Hong, Jung Jin Hwang, Seong-Yun Jeong, Shin Hwang, Ki-Hun Kim, Young-Joo Lee, Klaus P Hoeflich, Oleg Schmidt-Kittler, Stephen Miller, Eun Kyung Choi
BACKGROUND: The fibroblast growth factor receptor 4 (FGFR4) pathway is an essential regulatory component of bile acid synthesis, and its relationship with hepatocellular carcinoma (HCC) has been reported. We investigated the gene expression and clinical significance of FGFR4 and related pathways in intrahepatic cholangiocarcinoma (iCCA). RESULTS: The median age was 56 years (range 30-78) and 34 patients (74%) were male. Six patients (13%) had hepatitis B virus infection, with or without liver cirrhosis...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415155/letter-to-the-editor-regarding-dounousi-e-et%C3%A2-al-intact-fgf23-and-%C3%AE-klotho-during-acute-inflammation-sepsis-in-ckd-patients-eur-j-clin-invest-2016-46-234-41
#2
Axel Schlitt, Urban Sester, Martina Sester, Sarah Seiler-Mussler, Vincent Brandenburg, Elke Schäffner, Gunnar H Heine
With interest we read the recent European Journal of Clinical Investigation paper entitled "Intact FGF23 and α-Klotho during acute inflammation/sepsis in CKD patients" by E. Dounousi and coworkers (1). In their article, the authors analyse the association between acute infection and plasma levels of the phosphaturic hormone fibroblast growth factor 23 (FGF-23). The physiological regulation of FGF-23 is not fully understood so far, and hence novel pathophysiological data are of importance. Particularly the link between FGF23 and inflammation is a growing field...
April 17, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28378806/fibroblast-growth-factor-2-drives-and-maintains-progressive-corneal-neovascularization-following-hsv-1-infection
#3
H R Gurung, M M Carr, K Bryant, A J Chucair-Elliott, D Jj Carr
Herpes simplex virus type 1 (HSV-1) infection of the cornea induces vascular endothelial growth factor A (VEGF-A)-dependent lymphangiogenesis that continues to develop well beyond the resolution of infection. Inflammatory leukocytes infiltrate the cornea and have been implicated to be essential for corneal neovascularization, an important clinically relevant manifestation of stromal keratitis. Here we report that cornea infiltrating leukocytes including neutrophils and T cells do not have a significant role in corneal neovascularization past virus clearance...
April 5, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28246406/evaluation-of-recombinant-human-fgf-2-and-pdgf-bb-in-periodontal-regeneration-a-systematic-review-and-meta-analysis
#4
Feifei Li, Fanyuan Yu, Xin Xu, Chunjie Li, Dingming Huang, Xuedong Zhou, Ling Ye, Liwei Zheng
The prognosis for successful treatment of periodontal diseases is generally poor. Current therapeutic strategies often fail to regenerate infected periodontium. Recently an alternative strategy has been developed that combines conventional treatment with the application of recombinant human growth factors (rhGFs). But ambiguities in existed studies on the clinical efficacy of rhGFs do not permit either the identification of the specific growth factors effective for therapeutic interventions or the optimal concentration of them...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169840/bile-acid-disease-the-emerging-epidemic
#5
Ibironke Oduyebo, Michael Camilleri
PURPOSE OF REVIEW: Our objective was to review advances in bile acids in health and disease published in the last 2 years. Bile acid diarrhea (BAD) is recognized as a common cause of chronic diarrhea, and its recognition has been facilitated by development of new screening tests. RECENT FINDINGS: Primary BAD can account for 30% of cases of chronic diarrhea. The mechanisms leading to BAD include inadequate feedback regulation by fibroblast growth factor 19 (FGF-19) from ileal enterocytes, abnormalities in synthesis or degradation of proteins involved in FGF-19 regulation in hepatocytes and variations as a function of the bile acid receptor, TGR5 (GPBAR1)...
May 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28057033/reducing-the-risk-of-impaired-bone-apposition-to-titanium-screws-with-the-use-of-fibroblast-growth-factor-2-apatite-composite-layer-coating
#6
Kengo Fujii, Atsuo Ito, Hirotaka Mutsuzaki, Shinji Murai, Yu Sogo, Yuki Hara, Masashi Yamazaki
BACKGROUND: Loosening of screws is a common problem in orthopedic and maxillofacial surgery. Modifying the implant surface to improve the mechanical strength of screws has been tried and reported. We developed screws coated with fibroblast growth factor-2 (FGF-2)-apatite composite layers. We then showed, in a percutaneous external fixation model, that this composite layer had the ability to hold and release FGF-2 slowly, thereby reducing the risk of pin tract infection of the percutaneous external fixation...
January 5, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27863549/cytokine-and-chemokine-profiles-of-aqueous-humor-and-serum-in-horses-with-uveitis-measured-using-multiplex-bead-immunoassay-analysis
#7
Elizabeth Curto, Kristen M Messenger, Jacklyn H Salmon, Brian C Gilger
OBJECTIVE: To determine whether horses with clinically diagnosed Equine Recurrent Uveitis (ERU) and those with Leptospirosis infection have a specific cytokine profile in their aqueous humor (AH) and serum that differs from horses with uveitis secondary to other ocular inflammatory processes and from horses with normal eyes. ANIMALS STUDIED: Twenty-five client-owned horses with uveitis that were presented to the North Carolina State University Ophthalmology Service, and four University-owned horses without history or clinical signs of ocular disease...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27704252/extrarenal-effects-of-fgf23
#8
Dieter Haffner, Maren Leifheit-Nestler
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular mortality, infections, and impaired cognitive function. It is characterized by excessively increased levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23) and a deficiency of its co-receptor Klotho. Despite the important physiological effect of FGF23 in maintaining phosphate homeostasis, there is increasing evidence that higher FGF23 levels are a risk factor for mortality and cardiovascular disease. FGF23 directly induces left ventricular hypertrophy via activation of the FGF receptor 4/calcineurin/nuclear factor of activated T cells signaling pathway...
May 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27590203/fgf-and-eda-pathways-control-initiation-and-branching-of-distinct-subsets-of-developing-nasal-glands
#9
Alison J May, Denis Headon, David P Rice, Alistair Noble, Abigail S Tucker
Hypertrophy, hyperplasia and altered mucus secretion from the respiratory submucosal glands (SMG) are characteristics of airway diseases such as cystic fibrosis, asthma and chronic bronchitis. More commonly, hyper-secretion of the nasal SMGs contributes to allergic rhinitis and upper airway infection. Considering the role of these glands in disease states, there is a significant dearth in understanding the molecular signals that regulate SMG development and patterning. Due to the imperative role of FGF signalling during the development of other branched structures, we investigated the role of Fgf10 during initiation and branching morphogenesis of murine nasal SMGs...
November 15, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27470512/fibroblast-growth-factor-12-is-a-novel-regulator-of-vascular-smooth-muscle-cell-plasticity-and-fate
#10
Sun-Hwa Song, Kyungjong Kim, Eun-Kyung Jo, Young-Wook Kim, Jin-Sook Kwon, Sun Sik Bae, Jong-Hyuk Sung, Sang Gyu Park, Jee Taek Kim, Wonhee Suh
OBJECTIVE: Vascular smooth muscle cells (VSMCs) modulate their phenotype between synthetic and contractile states in response to environmental changes; this modulation plays a crucial role in the pathogenesis of restenosis and atherosclerosis. Here, we identified fibroblast growth factor 12 (FGF12) as a novel key regulator of the VSMC phenotype switch. APPROACH AND RESULTS: Using murine models and human specimens, we found that FGF12 was highly expressed in contractile VSMCs of normal vessel walls but was downregulated in synthetic VSMCs from injured and atherosclerotic vessels...
September 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27382436/fgf19-functions-as-autocrine-growth-factor-for-hepatoblastoma
#11
David J Elzi, Meihua Song, Barron Blackman, Susan T Weintraub, Dolores López-Terrada, Yidong Chen, Gail E Tomlinson, Yuzuru Shiio
Hepatoblastoma is the most common liver cancer in children, accounting for over 65% of all childhood liver malignancies. Hepatoblastoma is distinct from adult liver cancer in that it is not associated with hepatitis virus infection, cirrhosis, or other underlying liver pathology. The paucity of appropriate cell and animal models has been hampering the mechanistic understanding of hepatoblastoma pathogenesis. Consequently, there is no molecularly targeted therapy for hepatoblastoma. To gain insight into cytokine signaling in hepatoblastoma, we employed mass spectrometry to analyze the proteins secreted from Hep293TT hepatoblastoma cell line we established and identified the specific secretion of fibroblast growth factor 19 (FGF19), a growth factor for liver cells...
March 2016: Genes & Cancer
https://www.readbyqxmd.com/read/27330885/skeletal-muscle-wasting-and-renewal-a-pivotal-role-of-myokine-il-6
#12
REVIEW
José E Belizário, Cibely C Fontes-Oliveira, Janaina Padua Borges, Janete Akemi Kashiabara, Edouard Vannier
Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-renew by means of a controlled process of activation and proliferation of tissue-resident stem cells named satellite cells. Many growth factors, cytokines and myokines produced by skeletal muscle cells play critical roles in local regulation of the inflammatory process and skeletal muscle regeneration during different pathological conditions. IL-6 is a pleiotropic cytokine released in large amount during infection, autoimmunity and cancer...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27142667/characterization-of-the-viral-fibroblast-growth-factor-homolog-of-helicoverpa-armigera-single-nucleopolyhedrovirus
#13
Feifei Yin, Ruikun Du, Wenhua Kuang, Guang Yang, Hualin Wang, Fei Deng, Zhihong Hu, Manli Wang
Fibroblast growth factor (FGF) is found throughout multicellular organisms; however, fgf homologs (vfgf) have only been identified among viruses in lepidopteran baculoviruses. The function of vFGFs from Group I alphabaculoviruses, including Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and Bombyx mori nucleopolyhedrovirus (BmNPV), involves accelerated killing of infected larvae by both viruses. The vFGF of Group II alphabaculovirus is structurally different from that of Group I alphabaculovirus, with a larger C-terminal region and additional N-linked glycosylation sites...
June 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27097314/circulating-fibroblast-growth-factor-2-hiv-tat-and-vascular-endothelial-cell-growth-factor-a-in-hiv-infected-children-with-renal-disease-activate-rho-a-and-src-in-cultured-renal-endothelial-cells
#14
Jharna R Das, J Silvio Gutkind, Patricio E Ray
Renal endothelial cells (REc) are the first target of HIV-1 in the kidney. The integrity of REc is maintained at least partially by heparin binding growth factors that bind to heparan sulfate proteoglycans located on their cell surface. However, previous studies showed that the accumulation of two heparin-binding growth factors, Vascular Endothelial Cell Growth Factor-A (VEGF-A) and Fibroblast Growth Factor-2 (FGF-2), in combination with the viral protein Tat, can precipitate the progression of HIV-renal diseases...
2016: PloS One
https://www.readbyqxmd.com/read/27012053/the-superiority-of-an69st-membrane-in-the-adsorption-of-fibroblast-growth-factor-23
#15
COMPARATIVE STUDY
Yusuke Minematsu, Masafumi Yamato, Yuta Ikemiya, Takahito Ito
BACKGROUND: The most frequent cause of acute kidney injury (AKI) needing renal replacement therapy is sepsis, with the prognosis of patients with septic AKI worse than for other causes of this disease. Recent studies have shown that fibroblast growth factor-23 (FGF-23) levels, one of the phosphaturic and prognostic factors in chronic kidney disease, are also elevated in patients with AKI and correlate with an increased risk of death or a need for dialysis. In addition, FGF-23 was found to inhibit the extra-renal synthesis of 1,25-dihydroxyvitamin D by human monocytes...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/26919948/effect-of-lentivirus-mediated-integrin-%C3%AE-v%C3%AE-3-shrna-on-tumor-growth-of-mice-with-lung-cancer-xenografts
#16
Tao Liang, Yong-Fu Ma, Jian Chu, Dao-Xi Wang, Yang Liu
OBJECTIVE: To study the effect of lentivirus-mediated integrin αVβ3-shRNA on tumor growth of mice with lung cancer xenograft. METHODS: Lung cancer tissue, paracancer tissue and normal tissue were collected and integrin αVβ3 expression was detected; BALB/c nude mice were selected, divided into integrin αVβ3 knockdown group (KD group) and negative control group (NC group), and inoculated with cells stably infected by integrin αVβ3-shRNA lentivirus and cells stably infected by negative control-shRNA lentivirus, respectively, the growth of tumor tissue was continuously observed, and the number of apoptosis cells as well as the expression of angiogenesis, apoptosis and invasion genes in tumor tissue were detected...
February 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/26878171/fgf23-signaling-impairs-neutrophil-recruitment-and-host-defense-during-ckd
#17
Jan Rossaint, Jessica Oehmichen, Hugo Van Aken, Stefan Reuter, Hermann J Pavenstädt, Melanie Meersch, Mark Unruh, Alexander Zarbock
Chronic kidney disease (CKD) has been associated with impaired host response and increased susceptibility to infections. Leukocyte recruitment during inflammation must be tightly regulated to protect the host against pathogens. FGF23 levels are increased in blood during CKD, and levels of this hormone have been associated with a variety of adverse effects in CKD patients. Here, we have shown that CKD impairs leukocyte recruitment into inflamed tissue and host defense in mice and humans. FGF23 neutralization during CKD in murine models restored leukocyte recruitment and host defense...
March 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26872365/mir-214-attenuates-osteogenic-differentiation-of-mesenchymal-stem-cells-via-targeting-fgfr1
#18
Lei Yang, Dawei Ge, Xiaojian Cao, Yingbin Ge, Hongtao Chen, Weiwei Wang, Hongxiu Zhang
BACKGROUND/AIMS: Postmenopausal osteoporosis is closely associated with reduction in the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. Previous studies have demonstrated that miR-214 plays an important role in the genesis and development of postmenopausal osteoporosis. Here, we performed this study to investigate the potential mechanism by which miR-214 regulates osteoblast differentiation of MSCs. METHODS: First, we explored the expression of miR-214 in MSCs of osteoporotic mice...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26741963/a-cell-internalizing-antibody-targeting-capsid-protein-p24-inhibits-the-replication-of-hiv-1-in-t-cells-lines-and-pbmcs-a-proof-of-concept-study
#19
Syed A Ali, Sin-Yeang Teow, Tasyriq Che Omar, Alan Soo-Beng Khoo, Tan Soo Choon, Narazah Mohd Yusoff
There remains a need for newer therapeutic approaches to combat HIV/AIDS. Viral capsid protein p24 plays important roles in HIV pathogenesis. Peptides and small molecule inhibitors targeting p24 have shown to inhibit virus replication in treated cell. High specificity and biological stability of monoclonal antibodies (mAbs) make them an attractive contender for in vivo treatments. However, mAbs do not enter into cells, thus are restricted to target surface molecules. This also makes targeting intracellular HIV-1 p24 a challenge...
2016: PloS One
https://www.readbyqxmd.com/read/26650279/organoids-as-model-for-infectious-diseases-culture-of-human-and-murine-stomach-organoids-and-microinjection-of-helicobacter-pylori
#20
Sina Bartfeld, Hans Clevers
Recently infection biologists have employed stem cell derived cultures to answer the need for new and better models to study host-pathogen interactions. Three cellular sources have been used: Embryonic stem cells (ESC), induced pluripotent stem cells (iPSC) or adult stem cells. Here, culture of mouse and human gastric organoids derived from adult stem cells is described and used for infection with the gastric pathogen Helicobacter pylori. Human gastric glands are isolated from resection material, seeded in a basement matrix and embedded in medium containing growth factors epidermal growth factor (EGF), R-spondin, Noggin, Wnt, fibroblast growth factor (FGF) 10, gastrin and transforming growth factor (TGF) beta inhibitor...
2015: Journal of Visualized Experiments: JoVE
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