Le Li, Huan Wang, Shucai Pang, Liangshun Wang, Zhengkai Fan, Chunyu Ma, Shufen Yang, Joshua Banda, Qi Hui, Fangyi Lv, Haibing Fan, Tongzhou Huang, Xiaobi Zhang, Xiaojie Wang
Diabetic Keratopathy (DK), commonly associated with a hyperactive inflammatory response, is one of the most common eye complications of diabetes. The peptide hormone fibroblast growth factor 21 (FGF-21) has been demonstrated to have anti-inflammatory and antioxidant properties. However, whether administration of recombinant human (rh) FGF21 can potentially regulate DK is still unknown. Therefore, in this work we investigated the role of rhFGF-21 in the modulation of corneal epithelial wound healing, the inflammation response, and oxidative stress using type 1 diabetic mice and high glucose-treated human corneal epithelial cells (HCECs)...
August 4, 2023: Journal of Biological Chemistry