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https://www.readbyqxmd.com/read/27555298/loss-of-ctrp1-disrupts-glucose-and-lipid-homeostasis
#1
Susana Rodriguez, Xia Lei, Pia S Petersen, Stefanie Y Tan, Hannah C Little, G William Wong
C1q/TNF-related protein 1 (CTRP1) is a conserved plasma protein of the C1q family with notable metabolic and cardiovascular functions. We have previously shown that CTRP1 infusion lowers blood glucose and that transgenic mice with elevated circulating CTRP1 are protected from diet-induced obesity and insulin resistance. Here, we used a genetic loss-of-function mouse model to address the requirement of CTRP1 for metabolic homeostasis. Despite similar body weight, food intake, and energy expenditure, Ctrp1 knockout (KO) mice fed a low-fat diet developed insulin resistance and hepatic steatosis...
October 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27178737/exenatide-treatment-decreases-fasting-fibroblast-growth-factor-21-levels-in-patients-with-newly-diagnosed-type-2-diabetes-mellitus
#2
Y Hu, J Liu, H Zhang, Y Xu, T Hong, G Wang
AIM: Fibroblast growth factor 21 (FGF21) has been demonstrated to be a metabolic regulator with beneficial effects. Several studies have shown that type 2 diabetes mellitus (T2DM) patients have increased FGF21 levels and decreased expression of FGF receptors, suggesting a state of 'FGF21 resistance'. The aim of this study was to investigate the effects of the glucagon-like peptide (GLP)-1 receptor agonist exenatide on FGF21 levels and other metabolic parameters in patients with newly diagnosed T2DM...
May 10, 2016: Diabetes & Metabolism
https://www.readbyqxmd.com/read/27134062/insulin-resistance-postprandial-glp-1-and-adaptive-immunity-are-the-main-predictors-of-nafld-in-a-homogeneous-population-at-high-cardiovascular-risk
#3
L Bozzetto, G Annuzzi, M Ragucci, O Di Donato, G Della Pepa, G Della Corte, E Griffo, G Anniballi, A Giacco, M Mancini, A A Rivellese
BACKGROUND AND AIMS: The role of the different factors associated with fatty liver is still poorly defined. We evaluated the relationships between liver fat content (LF) and metabolic, inflammatory and nutritional factors in a homogeneous cohort of individuals at high cardio-metabolic risk. METHODS AND RESULTS: In 70 individuals with high waist circumference and at least one more criterion for metabolic syndrome enrolled in a nutritional intervention study, LF was evaluated at baseline by hepatic/renal echo intensity ratio (H/R), together with dietary habits (7-day dietary record), insulin sensitivity and β-cell function (fasting and OGTT-derived indices), fasting and postprandial plasma GLP-1 and lipoproteins, and plasma inflammatory markers...
July 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/26649086/laparoscopic-gastric-plication-and-its-effect-on-saccharide-and-lipid-metabolism-a-12-month-prospective-study
#4
Marek Bužga, Pavol Holéczy, Zdeněk Švagera, Pavel Zonča
INTRODUCTION: Laparoscopic greater curvature plication (LGCP) is a novel restrictive technique that reduces gastric volume by plication of the greater curvature. The advantage of LGCP is its reversibility in comparison to laparoscopic sleeve gastrectomy. Nowadays, the long-term LGCP efficacy, safety and metabolic effect are being investigated. AIM: To assess body composition, clinical complications and metabolic changes in obese patients 6 and 12 months after laparoscopic greater curvature plication...
September 2015: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/26409958/the-effect-of-grape-seed-and-grape-marc-meal-extract-on-milk-performance-and-the-expression-of-genes-of-endoplasmic-reticulum-stress-and-inflammation-in-the-liver-of-dairy-cows-in-early-lactation
#5
D K Gessner, C Koch, F-J Romberg, A Winkler, G Dusel, E Herzog, E Most, K Eder
During the periparturient phase, cows are typically in an inflammation-like condition, and it has been suggested that inflammation associated with the development of stress of the endoplasmic reticulum (ER) in the liver contributes to the development of fatty liver syndrome and ketosis. In the present study, we investigated the hypothesis that feeding grape seed and grape marc meal extract (GSGME) as a plant extract rich in flavonoids attenuates inflammation and ER stress in the liver of dairy cows. Two groups of cows received either a total mixed ration as a control diet or the same total mixed ration supplemented with 1% of GSGME over the period from wk 3 prepartum to wk 9 postpartum...
December 2015: Journal of Dairy Science
https://www.readbyqxmd.com/read/26382974/klotho-related-molecules-upregulated-by-smoking-habit-in-apparently-healthy-men-a-cross-sectional-study
#6
Kaori Nakanishi, Makoto Nishida, Masaya Harada, Tohru Ohama, Noritaka Kawada, Masaaki Murakami, Toshiki Moriyama, Keiko Yamauchi-Takihara
While aging is unavoidable, the aging mechanism is still unclear because of its complexity. Smoking causes premature death and is considered as an environmental aging accelerator. In the present study, we focused on the influence of smoking to the serum concentration of anti-aging protein α-klotho (αKl) and the β-klotho-associated protein fibroblast growth factor (FGF)-21 in men. Subjects consisted of apparently healthy men over 40 years of age who underwent health examination. Physical and biochemical parameters, including the levels of several cytokines and growth factors, were obtained from the subjects...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26045262/diet1-is-a-regulator-of-fibroblast-growth-factor-15-19-dependent-bile-acid-synthesis
#7
Karen Reue, Jessica M Lee, Laurent Vergnes
BACKGROUND: A fascinating aspect of bile acid homeostasis is the coordination between bile acid uptake in intestine and hepatic bile acid synthesis. In response to bile acid uptake in enterocytes, farnesoid X receptor is activated and induces transcription of fibroblast growth factor (FGF)15 in mice, or FGF19 in humans. FGF15/19 is secreted into the enterohepatic circulation, and through activation of hepatic receptors, leads to repression of Cyp7a1, a rate-limiting enzyme for bile acid synthesis...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/25612224/changes-in-bile-acids-fgf-19-and-sterol-absorption-in-response-to-bile-salt-hydrolase-active-l-reuteri-ncimb-30242
#8
Christopher J Martoni, Alain Labbé, Jorge G Ganopolsky, Satya Prakash, Mitchell L Jones
The size and composition of the circulating bile acid (BA) pool are important factors in regulating the human gut microbiota. Disrupted regulation of BA metabolism is implicated in several chronic diseases. Bile salt hydrolase (BSH)-active Lactobacillus reuteri NCIMB 30242, previously shown to decrease LDL-cholesterol and increase circulating BA, was investigated for its dose response effect on BA profile in a pilot clinical study. Ten otherwise healthy hypercholesterolemic adults, recruited from a clinical trial site in London, ON, were randomized to consume delayed release or standard release capsules containing L...
2015: Gut Microbes
https://www.readbyqxmd.com/read/25604607/fibroblast-growth-factor-19-targeted-therapies-for-the-treatment-of-metabolic-disease
#9
REVIEW
Jacek Rysz, Anna Gluba-Brzózka, Dimitri P Mikhailidis, Maciej Banach
INTRODUCTION: Fibroblast growth factors (FGFs) belong to the FGF superfamily with diverse biological functions, including proliferation, cellular differentiation, wound repair, angiogenesis and tumorigenesis. The ability to reduce liver fat content and concentrations of triglycerides, total cholesterol and plasma glucose, and to improve sensitivity and limit pro-lipogenic properties of insulin, makes FGF19 a promising therapeutic target for the treatment of metabolic syndrome. FGF19 regulates bile acid biosynthesis in the bile duct, glucose metabolism and vitamin D and phosphate homeostasis, raises the metabolic rate, reduces body weight, and ameliorates diabetes in mice...
May 2015: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/25598538/modulation-of-the-intestinal-microbiota-is-associated-with-lower-plasma-cholesterol-and-weight-gain-in-hamsters-fed-chardonnay-grape-seed-flour
#10
Hyunsook Kim, Dong-Hyeon Kim, Kun-Ho Seo, Jung-Whan Chon, Seung-Yeol Nah, Glenn E Bartley, Torey Arvik, Rebecca Lipson, Wallace Yokoyama
The relationship between the intestinal microbiota and the hypocholesterolemic and antiobesity effects of whole grape seed flour from white and red winemaking was evaluated. Male Golden Syrian hamsters were fed a high-fat (HF) control diet or a HF diet supplemented with 10% partially defatted grape seed flours from either Chardonnay (ChrSd) or Cabernet Sauvignon (CabSd) grapes for 3 weeks. The numbers of total bacteria and relative abundances of Bifidobacterium spp., Lactobacillus spp., and Firmicutes in feces were significantly lower, while the relative abundance of Bacteroides fragilis was greater than the control from feeding the ChrSd diet...
February 11, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25533425/differential-profile-in-inflammatory-and-mineral-metabolism-biomarkers-in-patients-with-ischemic-heart-disease-without-classical-coronary-risk-factors
#11
Ana María Pello, Carmen Cristóbal, Nieves Tarín, Ana Huelmos, Álvaro Aceña, Rocío Carda, María Luisa González-Casaus, Joaquín Alonso, Óscar Lorenzo, Luis Blanco-Colio, José Luis Martín-Ventura, Juan Antonio Franco Peláez, Ignacio Mahíllo-Fernández, Jerónimo Farré, Lorenzo López-Bescós, Jesús Egido, José Tuñón
BACKGROUND: Patients with coronary heart disease (CHD) without classical cardiovascular risk factors (CRFs) are uncommon, and their profile has not been thoroughly studied. In CHD patients, we have assessed the differences in several biomarkers between those with and without CRF. METHODS: We studied 704 patients with CHD, analyzing plasma levels of biomarkers related to inflammation, thrombosis, renal damage, and heart failure: high-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), galectin-3, N-terminal fragment of brain natriuretic peptide (NT-pro-BNP), calcidiol (vitamin D metabolite), fibroblast growth factor-23 (FGF-23), parathormone, and phosphate...
July 2015: Journal of Cardiology
https://www.readbyqxmd.com/read/25501997/thyroid-hormone-receptor-regulates-most-genes-independently-of-fibroblast-growth-factor-21-in-liver
#12
Aijun Zhang, Douglas H Sieglaff, Jean Philippe York, Ji Ho Suh, Stephen D Ayers, Glenn E Winnier, Alexei Kharitonenkov, Christopher Pin, Pumin Zhang, Paul Webb, Xuefeng Xia
Thyroid hormone (TH) acts through specific receptors (TRs), which are conditional transcription factors, to induce fibroblast growth factor 21 (FGF21), a peptide hormone that is usually induced by fasting and that influences lipid and carbohydrate metabolism via local hepatic and systemic endocrine effects. While TH and FGF21 display overlapping actions when administered, including reductions in serum lipids, according to the current models these hormones act independently in vivo. In this study, we examined mechanisms of regulation of FGF21 expression by TH and tested the possibility that FGF21 is required for induction of hepatic TH-responsive genes...
March 2015: Journal of Endocrinology
https://www.readbyqxmd.com/read/24724557/fibroblast-growth-factor-21-and-its-relation-to-metabolic-parameters-in-women-with-polycystic-ovary-syndrome
#13
Serap B Sahin, Teslime Ayaz, Medine C Cure, Hacer Sezgin, Ulku M Ural, Gulsah Balik, Figen K Sahin
OBJECTIVE: The aim of this study was to compare the serum levels of fibroblast growth factor 21 (FGF-21) between patients with polycystic ovary syndrome (PCOS) and control subjects and to assess the possible relation with the hormonal and metabolic parameters. METHODS: A total of 91 patients with PCOS and 53 age- and body mass index (BMI)-matched healthy controls were included in the study. We evaluated anthropometric, hormonal and metabolic parameters in all the cases...
September 2014: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/24638201/levels-of-circulating-selenoprotein-p-fibroblast-growth-factor-fgf-21-and-fgf23-in-relation-to-the-metabolic-syndrome-in-young-children
#14
B-J Ko, S M Kim, K H Park, H S Park, C S Mantzoros
BACKGROUND/OBJECTIVES: Circulating selenoprotein P (SeP), fibroblast growth factor (FGF) 21 and FGF23 have been associated with metabolic syndrome (MetS) in adults but not in children. We sought to evaluate the association among SeP, FGF21, FGF23 and MetS in young children. SUBJECTS/METHODS: A cross-sectional study conducted during a school health examination on 210 children aged 9 years. We measured serum SeP, FGF21 and FGF23 levels, and assessed anthropometric and cardiometabolic variables...
December 2014: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/24321096/srebp-2-negatively-regulates-fxr-dependent-transcription-of-fgf19-in-human-intestinal-cells
#15
Masaaki Miyata, Tatsuya Hata, Yasushi Yamazoe, Kouichi Yoshinari
Sterol regulatory element-binding protein-2 (SREBP-2) is a basic helix-loop-helix-leucine zipper transcription factor that positively regulates transcription of target genes involved in cholesterol metabolism. In the present study, we have investigated a possible involvement of SREBP-2 in human intestinal expression of fibroblast growth factor (FGF)19, which is an endocrine hormone involved in the regulation of lipid and glucose metabolism. Overexpression of constitutively active SREBP-2 decreased FGF19 mRNA levels in human colon-derived LS174T cells...
January 10, 2014: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24043573/different-associations-of-adipokines-in-lean-and-healthy-adults
#16
T Ebert, I Roth, J Richter, A Tönjes, S Kralisch, U Lossner, J Kratzsch, M Blüher, M Stumvoll, M Fasshauer
Regulation of adipokines in lean adults without metabolic disease and without eating disorders has not been comprehensively elucidated. We hypothesized that some of the established associations of these adipocyte-secreted proteins with anthropometric and biochemical measures of glucose homeostasis, lipid metabolism, renal function, as well as inflammation, differ in healthy and low weight adults as compared to overweight/obese patients. Eighty-one subjects with a body mass-index below 22.0 kg/m2 and without malnutrition or eating disorders, as well as fifty overweight/obese patients, were recruited for the study...
January 2014: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/23981342/additive-relationship-between-serum-fibroblast-growth-factor-21-level-and-coronary-artery-disease
#17
Yun Shen, Xiaojing Ma, Jian Zhou, Xiaoping Pan, Yaping Hao, Mi Zhou, Zhigang Lu, Meifang Gao, Yuqian Bao, Weiping Jia
BACKGROUND: Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development of several metabolic disorders. This study was designed to investigate whether serum FGF21 level was also associated with the metabolic syndrome-related cardiovascular disease, atherosclerosis, and its clinical features in a Chinese cohort. METHODS: Two-hundred-and-fifty-three subjects visiting the Cardiology Department (Sixth People's Hospital affiliated to Shanghai JiaoTong University) were examined by coronary arteriography (to diagnose coronary artery disease (CAD)) and hepatic ultrasonography (to diagnose non-alcoholic fatty liver disease (NAFLD))...
August 28, 2013: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/23729782/digestive-physiology-of-the-pig-symposium-intestinal-bile-acid-sensing-is-linked-to-key-endocrine-and-metabolic-signaling-pathways
#18
REVIEW
D Burrin, B Stoll, D Moore
Bile acids have historically been considered to mainly function in cholesterol homeostasis and facilitate fat digestion in the gastrointestinal tract. Recent discoveries show that bile acids also function as signaling molecules that exert diverse endocrine and metabolic actions by activating G protein-coupled bile acid receptor 1 (GPBAR1/G-protein-coupled bile acid receptor 1 or TGR5), a membrane G protein-coupled receptor, and farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily...
May 2013: Journal of Animal Science
https://www.readbyqxmd.com/read/23545215/serum-levels-of-the-adipokine-fibroblast-growth-factor-21-are-increased-in-preeclampsia
#19
Holger Stepan, Karoline Kley, Janka Hindricks, Susan Kralisch, Alexander Jank, Wiebke Schaarschmidt, Susanne Schrey, Thomas Ebert, Ulrike Lössner, Jürgen Kratzsch, Matthias Blüher, Michael Stumvoll, Judit Richter, Mathias Fasshauer
BACKGROUND: Preeclampsia (PE) is a serious cardiovascular complication in pregnancy, which is associated with an increased future metabolic and cardiovascular risk for mother and newborn. Fibroblast growth factor (FGF)-21 was recently introduced as a novel adipokine improving glucose metabolism in vitro and in vivo. MATERIAL AND METHODS: We investigated serum FGF-21 levels in patients with PE (n=51) as compared to healthy, age-matched controls (n=51) during and 6 months after pregnancy...
May 2013: Cytokine
https://www.readbyqxmd.com/read/23204296/dual-actions-of-fibroblast-growth-factor-19-on-lipid-metabolism
#20
Xinle Wu, Hongfei Ge, Hélène Baribault, Jamila Gupte, Jennifer Weiszmann, Bryan Lemon, Jonitha Gardner, Preston Fordstrom, Jie Tang, Mingyue Zhou, Minghan Wang, Yang Li
Elevated triglyceride (TG) and cholesterol levels are risk factors for cardiovascular disease and are often associated with diabetes and metabolic syndrome. Recent reports suggest that fibroblast growth factor (FGF)19 and FGF21 can dramatically improve metabolic dysfunction, including hyperglycemia, hypertriglyceridemia, and hypercholesterolemia. Due to their similar receptor specificities and co-receptor requirements, FGF19 and FGF21 share many common properties and have been thought to be interchangeable in metabolic regulation...
February 2013: Journal of Lipid Research
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