Louisa Bloudeau, Agnès Linglart, Sacha Flammier, Aurélie Portefaix, Aurélia Bertholet-Thomas, Sanaa Eddiry, Anna Barosi, Jean-Pierre Salles, Valérie Porquet-Bordes, Anya Rothenbuhler, Christelle Roger, Justine Bacchetta
BACKGROUND: The underlying mechanisms of obesity in X-linked hypophosphatemia (XLH) are not known. We aimed to evaluate whether FGF21, an endocrine FGF involved in the regulation of carbohydrate-lipid metabolism, could be involved. METHODS: We performed a prospective multicenter cross-sectional study comparing FGF23, Klotho, and FGF21 levels in teenagers with XLH compared to healthy controls (VITADOS cohort) after matching for age, gender, and puberty. Non-parametric tests were performed (results presented as median (min-max))...
June 27, 2022: Pediatric Nephrology