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https://www.readbyqxmd.com/read/29346612/hyperpyrexia-in-a-patient-with-a-left-ventricular-assist-device-a-diagnosis-beyond-the-obvious
#1
Michalis Tsamatsoulis, Chris J Kapelios, Christos Charitos
As the number of patients receiving a left ventricular assist device increases, physicians must always keep in mind that several conditions can present with non-specific symptoms, such as fever, tachypnoea and confusion. We herein report the case of a left ventricular assist device patient who developed a life-threatening condition with acute hyperthermia, confusion and extremities' clonus and muscle spasms. The patient was diagnosed with serotonin syndrome, attributed to the coadministration of 2 commonly prescribed medications (citalopram and omeprazole)...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29338602/sequential-drug-treatment-algorithm-for-agitation-and-aggression-in-alzheimer-s-and-mixed-dementia
#2
Simon Jc Davies, Amer M Burhan, Donna Kim, Philip Gerretsen, Ariel Graff-Guerrero, Vincent L Woo, Sanjeev Kumar, Sarah Colman, Bruce G Pollock, Benoit H Mulsant, Tarek K Rajji
INTRODUCTION: Behavioural and psychological symptoms of dementia (BPSD) include agitation and aggression in people with dementia. BPSD is common on inpatient psychogeriatric units and may prevent individuals from living at home or in residential/nursing home settings. Several drugs and non-pharmacological treatments have been shown to be effective in reducing behavioural and psychological symptoms of dementia. Algorithmic treatment may address the challenge of synthesizing this evidence-based knowledge...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29334745/-citalopram-and-qt-prolongation
#3
Štefan Alušík, Zoltán Paluch
In 2011/2012, the US Food and Drug Administration issued a warning about the effect of citalopram on the QT interval and decreased its dosing. Further studies addressing this issue have been published since then. The authors were interested to know whether or not the studies have furnished new information that could modify or further specify the FDA-issued recommendations. After analyzing the most relevant studies, the authors concluded that even papers published within the last 5 years confirmed that, of the SSRI class of drugs, citalopram prolongs the QT interval most significantly...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29317102/the-role-of-chronic-nutritional-supplements-consumption-in-a-fulminant-serotonin-syndrome-due-to-citalopram-intoxication
#4
I de Dios, G Rialp, S Franco, M Romero, M Ortega, Y Nieto
No abstract text is available yet for this article.
January 6, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29287270/sorption-of-citalopram-irbesartan-and-fexofenadine-in-soils-estimation-of-sorption-coefficients-from-soil-properties
#5
Aleš Klement, Radka Kodešová, Martina Bauerová, Oksana Golovko, Martin Kočárek, Miroslav Fér, Olga Koba, Antonín Nikodem, Roman Grabic
The sorption of 3 pharmaceuticals, which may exist in 4 different forms depending on the solution pH (irbesartan in cationic, neutral and anionic, fexofenadine in cationic, zwitter-ionic and anionic, and citalopram cationic and neutral), in seven different soils was studied. The measured sorption isotherms were described by Freundlich equations, and the sorption coefficients, KF (for the fixed n exponent for each compound), were related to the soil properties to derive relationships for estimating the sorption coefficients from the soil properties (i...
December 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/29275963/qt-prolongation-torsades-de-pointes-and-psychotropic-medications-a-5-year-update
#6
REVIEW
Scott R Beach, Christopher M Celano, Alan M Sugrue, Caitlin Adams, Michael J Ackerman, Peter A Noseworthy, Jeff C Huffman
BACKGROUND: Some psychotropic medications have been associated with prolongation of the QT interval and QT prolongation, especially in those with medical illness, and are linked to lethal ventricular arrhythmias, such as Torsades de Pointes (TdP). In 2013, we published a review of QT prolongation, TdP, and psychotropic medications. OBJECTIVE: We provide an update over the past 5 years on the specific concerns most relevant to clinicians who see medically ill patients...
November 3, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29259144/antidepressants-for-depression-associated-with-traumatic-brain-injury-a-meta-analytical-study-of-randomised-controlled-trials
#7
A Paraschakis, A H Katsanos
INTRODUCTION: Depression following traumatic brain injury is experienced by 16% to 60% of affected patients. The present study aimed to update the best evidence-based pharmacological treatments for tackling such chronic and debilitating disorders. METHODS: We systematically reviewed and meta-analysed randomised controlled trials published from 1990 until August 2017 that compared the efficacy of antidepressants with placebo in the treatment of post-traumatic brain injury depression...
December 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/29258890/serotonergic-and-cholinergic-modulation-of-functional-brain-connectivity-a-comparison-between-young-and-older-adults
#8
Bernadet L Klaassens, Joop M A van Gerven, Erica S Klaassen, Jeroen van der Grond, Serge A R B Rombouts
Aging is accompanied by changes in neurotransmission. To advance our understanding of how aging modifies specific neural circuitries, we examined serotonergic and cholinergic stimulation with resting state functional magnetic resonance imaging (RS-fMRI) in young and older adults. The instant response to the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was measured in 12 young and 17 older volunteers during a randomized, double blind, placebo-controlled, crossover study...
December 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/29244076/reference-brain-blood-concentrations-of-citalopram-duloxetine-mirtazapine-and-sertraline
#9
Michael Nedahl, Sys Stybe Johansen, Kristian Linnet
Postmortem blood samples may not accurately reflect antemortem drug concentrations, as the levels of some drugs increase due to postmortem redistribution (PMR). The brain has been suggested as an alternative sampling site. The anatomically secluded site of the brain limits redistribution and prolongs the detection window, thereby enabling sampling from deceased individuals where blood is no longer suitable for analysis. We report concentrations in brain tissue and blood from 91 cases for the four antidepressants citalopram, duloxetine, mirtazapine and sertraline...
December 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29241655/citalopram-restores-short-term-memory-deficit-and-non-cognitive-behaviors-in-app-ps1-mice-while-halting-the-advance-of-alzheimer-s-disease-like-pathology
#10
Qin Zhang, Chen Yang, Tianyao Liu, Liang Liu, Fen Li, Yulong Cai, Keyi Lv, Xin Li, Junwei Gao, Dayu Sun, Haiwei Xu, Qingwu Yang, Xiaotang Fan
Alzheimer's disease (AD) is the most common cause of dementia. In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in AD. Here, we show that complex behavioral deficits in 6-month-old APPswe/PSEN1dE9 (APP/PS1) mice include impairments in object recognition, deficient social interaction, increased depression and buried marbles. Citalopram, one of the selective serotonin reuptake inhibitors (SSRIs), ameliorated the amyloid deposition in AD patients and transgenic animal models...
December 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29238651/management-of-treatment-resistant-panic-disorder
#11
REVIEW
Giampaolo Perna, Daniela Caldirola
Purpose of Review: Purpose of Review Management of treatment-resistant (TR) panic disorder (PD) is an unresolved issue. In this paper, we provide a brief summary of previous findings, an updated (2015-2017) systematic review of pharmacological/non-pharmacological studies, and our personal perspective on this topic. Recent Findings: Recent Findings We found a very limited number of recent findings. Quetiapine extended-release augmentation has not been found to be beneficial, in comparison to placebo, in non-responders to previously recommended pharmacotherapy...
2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/29208964/reduced-anxiety-is-associated-with-the-accumulation-of-six-serotonin-reuptake-inhibitors-in-wastewater-treatment-effluent-exposed-goldfish-carassius-auratus
#12
D B D Simmons, E S McCallum, S Balshine, B Chandramouli, J Cosgrove, J P Sherry
Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus) for 21-days at three sites along a contamination gradient downstream from a WWTP which discharges into Cootes Paradise Marsh, on the western tip of Lake Ontario. We also included a fourth caging site as an external reference site within Lake Ontario at the Jordan Harbour Conservation Area...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205633/a-combined-connectivity-mapping-and-pharmacoepidemiology-approach-to-identify-existing-medications-with-breast-cancer-causing-or-preventing-properties
#13
John Busby, Liam Murray, Ken Mills, Shu-Dong Zhang, Fabio Liberante, Chris R Cardwell
PURPOSE: We applied a novel combined connectivity mapping and pharmacoepidemiological approach to identify medications that alter breast cancer risk. METHODS: The connectivity mapping process identified 6 potentially cancer-causing (meloxicam, azithromycin, rizatriptan, citalopram, rosiglitazone, and verapamil) and 4 potentially cancer-preventing (bendroflumethiazide, sertraline, fluvastatin, and budesonide) medications that were suitable for pharmacoepidemiological investigation...
December 4, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29197738/efficacy-and-safety-of-levomilnacipran-vilazodone-and-vortioxetine-compared-with-other-second-generation-antidepressants-for-major-depressive-disorder-in-adults-a-systematic-review-and-network-meta-analysis
#14
REVIEW
Gernot Wagner, Marie-Therese Schultes, Viktoria Titscher, Birgit Teufer, Irma Klerings, Gerald Gartlehner
BACKGROUND: Second-generation antidepressants dominate the medical management of major depressive disorder (MDD). Levomilnacipran, vilazodone and vortioxetine are the latest therapeutic options approved for the treatment of MDD. This systematic review aims to compare the benefits and harms of vilazodone, levomilnacipran, and vortioxetine with one another and other second-generation antidepressants. METHODS: We searched electronic databases up to September 2017 and reviewed reference lists and pharmaceutical dossiers to detect published and unpublished studies...
November 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29197244/systematic-assessment-of-different-solvents-for-the-extraction-of-drugs-of-abuse-and-pharmaceuticals-from-an-authentic-hair-pool
#15
Milena M Madry, Thomas Kraemer, Markus R Baumgartner
Hair analysis has been established as a prevalent tool for retrospective drug monitoring. In this study, different extraction solvents for the determination of drugs of abuse and pharmaceuticals in hair were evaluated for their efficiency. A pool of authentic hair from drug users was used for extraction experiments. Hair was pulverized and extracted in triplicate with seven different solvents in a one- or two-step extraction. Three one- (methanol, acetonitrile, and acetonitrile/water) and four two-step extractions (methanol two-fold, methanol and methanol/acetonitrile/formate buffer, methanol and methanol/formate buffer, and methanol and methanol/hydrochloric acid) were tested under accurately equal experimental conditions...
November 23, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29185803/better-tolerance-of-citalopram-in-a-breastfed-infant-who-could-not-tolerate-sertraline-and-paroxetine
#16
Faruk Uguz
Postpartum depression is frequently observed in women. First-line antidepressants in treatment of postpartum depression are selective serotonin reuptake inhibitors (SSRIs). Although SSRIs are well tolerated by most breastfed infants, some adverse events may arise in exposed infants. This report presents the case of an infant of a breastfeeding woman using citalopram without any problem after sertraline and paroxetine were discontinued due to adverse events in the infant.
November 29, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29181593/real-patient-and-its-virtual-twin-application-of-quantitative-systems-toxicology-modelling-in-the-cardiac-safety-assessment-of-citalopram
#17
Nikunjkumar Patel, Barbara Wiśniowska, Masoud Jamei, Sebastian Polak
A quantitative systems toxicology (QST) model for citalopram was established to simulate, in silico, a 'virtual twin' of a real patient to predict the occurrence of cardiotoxic events previously reported in patients under various clinical conditions. The QST model considers the effects of citalopram and its most notable electrophysiologically active primary (desmethylcitalopram) and secondary (didesmethylcitalopram) metabolites, on cardiac electrophysiology. The in vitro cardiac ion channel current inhibition data was coupled with the biophysically detailed model of human cardiac electrophysiology to investigate the impact of (i) the inhibition of multiple ion currents (IKr, IKs, ICaL); (ii) the inclusion of metabolites in the QST model; and (iii) unbound or total plasma as the operating drug concentration, in predicting clinically observed QT prolongation...
November 27, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29179578/impact-of-ssri-therapy-on-risk-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-dementia-in-individuals-with-previous-depression
#18
Claudia Bartels, Michael Wagner, Steffen Wolfsgruber, Hannelore Ehrenreich, Anja Schneider
OBJECTIVE: Depression is associated with an increased risk of Alzheimer's disease. Research has shown that the selective serotonin reuptake inhibitor (SSRI) citalopram decreases amyloid-β generation and plaque load. The authors evaluated the impact of SSRI treatment on CSF biomarkers and progression from mild cognitive impairment (MCI) to Alzheimer's dementia. METHOD: Data sets from 755 currently nondepressed participants from the longitudinal Alzheimer's Disease Neuroimaging Initiative were evaluated by Kaplan-Meier analysis and analyses of variance and covariance with ApoE4 status and age as covariates...
November 28, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29173600/a-practical-approach-to-avoiding-cardiovascular-adverse-effects-of-psychoactive-medications
#19
REVIEW
Judith Brouillette, Stanley Nattel
Drugs that act on mental state, generally termed "psychoactive agents," are among the most widely used medications in medicine. Psychoactive agents can affect the cardiovascular system and must be used carefully to avoid negative cardiovascular consequences. In the present article we review the potential adverse cardiovascular consequences of psychoactive medications and provide suggestions for practical approaches to avoiding them. We consider adverse reactions in terms of: (1) arrhythmias (particularly acquired long QT syndrome); (2) blood pressure; (3) ventricular function; (4) effect on risk factors; (5) teratogenicity; and (6) drug interactions...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29169770/fatal-serotonin-syndrome-in-a-patient-with-marchiafava-bignami-disease-combined-neurological-and-psychiatric-emergency
#20
Saeed Alghamdi, Yehya Seddeq, Hussein Algahtani, Bader Shirah
Marchiafava-Bignami disease (MBD) is a rare fatal neurological disorder characterized by demyelination, primary degeneration, and necrosis of the corpus callosum. Although MBD is mostly associated with chronic alcohol consumption and malnutrition, it has been reported in non-alcoholic patients. Serotonin syndrome is a rare but potentially fatal side effect of antidepressants that results from overstimulation of both central and peripheral serotonergic receptors. In this report, we present a case with fatal serotonin syndrome happening in a non-alcoholic patient with the chronic form of MBD...
October 31, 2017: Neurologia i Neurochirurgia Polska
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