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https://www.readbyqxmd.com/read/28645134/-arterial-hyper-and-hypotension-associated-with-psychiatric-medications-a-risk-assessment-based-on-the-summaries-of-product-characteristics-smpcs
#1
Roland W Freudenmann, Ninja Freudenmann, Bartosz Zurowski, Carlos Schönfeldt-Lecuona, Ludwig Maier, Roland E Schmieder, Christian Lange-Asschenfeldt, Maximilian Gahr
Introduction Psychiatric medications are well-known triggers of clinically relevant blood pressure changes. Therefore, we aimed at creating ranking lists for their risk of causing arterial hyper- or hypotension. Methods We analyzed 784 Summaries of Product characteristics (SmPCs, available online from "Rote Liste" or "Gelbe Liste" websites) from 105 psychiatric medications registered in adult psychiatry in Germany and extracted the standardized reported risks of increasing or decreasing arterial blood pressure...
June 23, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28628496/proton-pump-inhibitor-and-selective-serotonin-reuptake-inhibitor-therapy-for-the-management-of-noncardiac-chest-pain
#2
Nikos Viazis, Konstantina Katopodi, George Karamanolis, Konstantinos Denaxas, Lazaros Varytimiadis, Michail Galanopoulos, Emmanouela Tsoukali, Dimitirs Kamberoglou, Angeliki Christidou, Dimitrios G Karamanolis, George Papatheodoridis, Gerasimos J Mantzaris
INTRODUCTION: Although gastroesophageal reflux disease is the main cause of noncardiac chest pain (NCCP), proton pump inhibitors (PPIs) benefit a minority of patients. Our prospective study evaluated the effect of PPI and selective serotonin reuptake inhibitors on the different subtypes of NCCP characterized by impedance-pH monitoring. METHODS: All NCCP patients underwent impedance-pH monitoring and on the basis of the results, those with abnormal distal esophageal acid exposure received PPIs twice daily (group A), those with a positive symptom index for chest pain received citalopram 20 mg and PPI once daily (group B), and those with a negative symptom index for chest pain received citalopram 20 mg once daily (group C)...
June 16, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28619470/whole-body-hyperthermia-and-a-subthreshold-dose-of-citalopram-act-synergistically-to-induce-antidepressant-like-behavioral-responses-in-adolescent-rats
#3
Matthew W Hale, Jodi L Lukkes, Kathleen F Dady, Kyle J Kelly, Evan D Paul, David G Smith, Charles L Raison, Christopher A Lowry
BACKGROUND: Open and randomized, double blind, placebo-controlled clinical trials have demonstrated clinical efficacy of infrared whole-body hyperthermia in treatment of major depressive disorder (MDD). Demonstration of antidepressant-like behavioral effects of whole-body hyperthermia in preclinical rodent models would provide further support for the clinical use of infrared whole-body hyperthermia for the treatment of MDD, and would provide additional opportunities to explore underlying mechanisms...
June 12, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28608626/serotonergic-5httlpr-rs25531-s-allele-homozygosity-associates-with-violent-suicides-in-male-citalopram-users
#4
Anna-Liina Rahikainen, Salla Majaharju, Jari Haukka, Jukka U Palo, Antti Sajantila
Depressive disorders are involved as a background factor in over 50% of suicide cases. The most widely used antidepressants today are serotonin selective reuptake inhibitors (SSRIs). However, not all users benefit from SSRI medication. Although the overall number of suicides in Finland have decreased notably during the last decade, the annual rate is still relatively high, particularly in male population. In this study, we tested the hypothesis that the genetic variants associated with decreased citalopram efficiency, 5HTTLPR/rs25531, and increased impulsive behavior, MAOA-uVNTR and HTR2B Q20*, are more frequent among citalopram users committing suicide than among the citalopram users in general...
June 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28599860/molecularly-imprinted-nanoparticles-grafted-to-porous-silica-as-chiral-selectors-in-liquid-chromatography
#5
Raquel Gutierrez-Climente, Alberto Gomez-Caballero, Antonio Guerreiro, Deiene Garcia-Mutio, Nora Unceta, M Aránzazu Goicolea, Ramon J Barrio
The work presented here explores the grafting of molecularly imprinted nanoparticles (MIN) on silica beads for the development of new chiral stationary phases (CSP). Both solid-phase imprinting and precipitation polymerisation were tested for MIN synthesis though the latter approach was the only one that provided efficient chiral selectors. MIN particles were prepared by iniferter polymerisation initiated by UV radiation, using itaconic acid as functional monomer and ethylene dimethacrylate as cross-linker...
June 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28570499/stable-remission-of-multiple-chemical-sensitivity-syndrome-and-major-depression-with-citalopram-and-1-month-deep-transcranial-magnetic-stimulation-a-case-report
#6
Antonio Del Casale, Chiara Rapinesi, Georgios D Kotzalidis, Serena Sorice, Alessio Padovano, Giovanna Gentile, Gloria Angeletti, Stefano Ferracuti, Gabriele Sani, Maurizio Pompili, Maurizio Simmaco, Paolo Girardi
No abstract text is available yet for this article.
May 31, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28549262/passive-sampling-of-wastewater-as-a-tool-for-the-long-term-monitoring-of-community-exposure-illicit-and-prescription-drug-trends-as-a-proof-of-concept
#7
J A Baz-Lomba, Christopher Harman, Malcolm Reid, Kevin V Thomas
A passive sampling device, the Polar Organic Chemical Integrative Sampler (POCIS), was calibrated in-situ over a 4-week period in Oslo (Norway) for 10 illicit drugs and pharmaceuticals with the goal of developing an approach for monitoring long-term wastewater drug loads. The calibrations were performed in triplicate using three different overlapping calibration sets under changing environmental conditions that allowed the uncertainty of the sampling rates to be evaluated. All 10 compounds exhibited linear uptake kinetics and provided sampling rates of between 0...
May 20, 2017: Water Research
https://www.readbyqxmd.com/read/28544353/chiral-separation-of-12-pairs-of-enantiomers-by-capillary-electrophoresis-using-heptakis-2-3-diacetyl-6-sulfato-%C3%AE-cyclodextrin-as-the-chiral-selector-and-the-elucidation-of-the-chiral-recognition-mechanism-by-computational-methods
#8
Yaqi Yao, Peilu Song, Xiaoli Wen, Miaoduo Deng, Jian Wang, Xingjie Guo
Chiral separation of 12 pairs of basic analyte enantiomers including oxybutynin, bambuterol, tradinterol, clenbuterol, clorprenaline, terbutaline, tulobuterol, citalopram, phencynonate, fexofenadine, salbutamol and penehyclidine was conducted by capillary electrophoresis using a single-isomer anionic β-cyclodextrin derivative, heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin as the chiral selector. Parameters influencing separation were studied, including background electrolyte pH, heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin concentration, buffer concentration and separation voltage...
May 24, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28541924/characterizing-highly-benefited-patients-in-randomized-clinical-trials
#9
Vivek Charu, Paul B Rosenberg, Lon S Schneider, Lea T Drye, Lisa Rein, David Shade, Constantine G Lyketsos, Constantine E Frangakis
Physicians and patients may choose a certain treatment only if it is predicted to have a large effect for the profile of that patient. We consider randomized controlled trials in which the clinical goal is to identify as many patients as possible that can highly benefit from the treatment. This is challenging with large numbers of covariate profiles, first, because the theoretical, exact method is not feasible, and, second, because usual model-based methods typically give incorrect results. Better, more recent methods use a two-stage approach, where a first stage estimates a working model to produce a scalar predictor of the treatment effect for each covariate profile; and a second stage estimates empirically a high-benefit group based on the first-stage predictor...
May 20, 2017: International Journal of Biostatistics
https://www.readbyqxmd.com/read/28528584/autism-risk-following-antidepressant-medication-during-pregnancy
#10
A Viktorin, R Uher, A Reichenberg, S Z Levine, S Sandin
BACKGROUND: Previous studies have examined if maternal antidepressant medication during pregnancy increase the risk of autism spectrum disorder (ASD) in the offspring, but the results have been conflicting. METHODS: In a population-based cohort of 179 007 children born in 2006 and 2007 and followed through 2014 when aged 7 and 8, we estimated relative risks (RRs) of ASD and 95% confidence intervals (CIs) from Cox regression in children exposed to any antidepressant medication during pregnancy, and nine specific antidepressant drugs...
May 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28527719/involvement-of-serotonin-in-the-ventral-tegmental-area-in-thermoregulation-of-freely-moving-rats
#11
Takayuki Ishiwata, Hiroshi Hasegawa, Benjamin N Greenwood
We have recently reported that the serotonin (5-HT) projections from the midbrain's raphe nuclei that contains 5-HT cell bodies may play a role both in heat production and in heat loss. The purpose of the present study was to clarify the involvement of 5-HT in the ventral tegmental area (VTA), where 5-HT is suggested to participate in thermoregulation, using the combined methods of telemetry, microdialysis, and high performance liquid chromatography, with a special emphasis on regulation of the body temperature (Tb) in freely moving rats...
May 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28522397/cellulose-acetate-poly-lactic-acid-coaxial-wet-electrospun-scaffold-containing-citalopram-loaded-gelatin-nanocarriers-for-neural-tissue-engineering-applications
#12
Mahdi Naseri-Nosar, Majid Salehi, Shahriar Hojjati-Emami
The current study aimed to develop a biodegradable three-dimensional drug-loaded scaffold with the core-shell structured fibrils using coaxial wet-electrospinning for neural tissue engineering application. Poly lactic acid was wet-electrospun as the core, whereas cellulose acetate was fabricated into the fibril's shell. The scaffold then was coated with the citalopram-loaded gelatin nanocarriers (CGNs) produced by nanoprecipitation method. Scanning electron microscope observation revealed that the fibrils formed a nonwoven structure with the average diameter of ∼950nm...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28511118/simultaneous-determination-of-selective-serotonin-reuptake-inhibitors-and-their-main-metabolites-in-human-breast-milk-by-liquid-chromatography-electrospray-mass-spectrometry
#13
Etienne Weisskopf, Alice Panchaud, Kim An Nguyen, Delphine Grosjean, Jean-Michel Hascoët, Chantal Csajka, Chin B Eap, Nicolas Ansermot
A bioanalytical method by high performance liquid chromatography coupled to electrospray mass spectrometry (HPLC-ESI-MS), adapted from a previously published method in plasma, was validated in breast milk for the simultaneous quantification of all antidepressants belonging to the class of selective serotonin reuptake inhibitors (citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) and their major metabolites (desmethylcitalopram and norfluoxetine). Milk samples (250μl) first underwent protein precipitation followed by solid-phase extraction on a reversed phase/cation exchange sorbent...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28494335/ultrasound-assisted-low-density-solvent-dispersive-liquid-liquid-microextraction-for-the-simultaneous-determination-of-12-new-antidepressants-and-2-antipsychotics-in-whole-blood-by-gas-chromatography-mass-spectrometry
#14
Xiujuan Chen, Shuiqing Zheng, Jian Le, Zheyuan Qian, Runsheng Zhang, Zhanying Hong, Yifeng Chai
Antidepressant drugs are widely used in the treatment of different psychiatric disorders, as well as in conjunction with antipsychotics for the treatment of major depressive disorder. In this study, a simple and rapid ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction (UA-LDS-DLLME) method was developed for the simultaneous determination of 12 new antidepressants (norfluoxetine, fluoxetine, fluvoxamine, agomelatine, mirtazapine, moclobemide, melitracen, N-desmethylmirtazapine, maprotiline, sertraline, citalopram, paroxetine) and 2 antipsychotics (clozapine and haloperidol) in human whole blood by gas chromatography-mass spectrometry (GC-MS)...
April 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28493335/response-of-htr3a-ko-mice-to-antidepressant-treatment-and-chronic-stress
#15
Vincent Martin, Armance Riffaud, Tevrasamy Marday, Charly Brouillard, Bernard Franc, Jean-Pol Tassin, Caroline Sevoz-Couche, Raymond Mongeau, Laurence Lanfumey
BACKGROUND AND PURPOSE: It has recently been suggested that 5-HT3 receptor blockade enhances selective serotonin reuptake inhibitor (SSRI) antidepressants efficacy and may reverse stress-induced deficits in rodents. EXPERIMENTAL APPROACH: To further explore this hypothesis, we used mice lacking the 5-HT3 receptor (Htr3a KO) and their wild-type (WT) controls to assess their response in behavioural paradigms relevant to anxiety and depression. Mice were studied under basal, antidepressant treatments and chronic social defeat stress (CSDS) conditions...
May 10, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28470399/predicting-relapse-with-individual-residual-symptoms-in-major-depressive-disorder-a-reanalysis-of-the-star-d-data
#16
Hitoshi Sakurai, Takefumi Suzuki, Kimio Yoshimura, Masaru Mimura, Hiroyuki Uchida
BACKGROUND: Residual symptoms are detrimental to prognosis in major depressive disorder (MDD); however, little is known about the contribution of each residual symptom in predicting outcomes. The objective of this analysis was to identify which individual symptoms, based on self-report and clinician interview, could predict subsequent relapse. METHODS: The data of 1133 outpatients with nonpsychotic MDD who entered a 12-month naturalistic follow-up phase after achieving remission with level 1 treatment (i...
May 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28467792/assessment-of-citalopram-and-escitalopram-on-neuroblastoma-cell-lines-cell-toxicity-and-gene-modulation
#17
Laurent Sakka, Nathalie Delétage, Maryse Chalus, Youssef Aissouni, Valérie Sylvain-Vidal, Stéphane Gobron, Guillaume Coll
Selective serotonin reuptake inhibitors (SSRI) are common antidepressants which cytotoxicity has been assessed in cancers notably colorectal carcinomas and glioma cell lines. We assessed and compared the cytotoxicity of 2 SSRI, citalopram and escitalopram, on neuroblastoma cell lines. The study was performed on 2 non-MYCN amplified cell lines (rat B104 and human SH-SY5Y) and 2 human MYCN amplified cell lines (IMR32 and Kelly). Citalopram and escitalopram showed concentration-dependent cytotoxicity on all cell lines...
April 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28457161/clarifying-methods-in-a-study-of-outcomes-of-citalopram-dosage-risk-mitigation-in-a-veteran-population-response-to-krijnsen-et-al
#18
Thomas S Rector
No abstract text is available yet for this article.
May 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28457157/citalopram-discontinuation-more-harmful-than-gradual-dosage-reduction
#19
Petrus J C Krijnsen, Titus W D P van Os, Lex Wunderink
No abstract text is available yet for this article.
May 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28454498/efficacy-of-citalopram-on-acute-ischemic-stroke-outcome-a-randomized-clinical-trial
#20
Daryoush Savadi Oskouie, Ehsan Sharifipour, Homayoun Sadeghi Bazargani, Mazyar Hashemilar, Masoud Nikanfar, Saeed Ghazanfari Amlashi, Zahra Abbaszade, Elyar Sadeghihokmabadi, Reza Rikhtegar, Samad E J Golzari
BACKGROUND AND PURPOSE: Ischemic stroke (IS) is one of the main causes of death and disability in the adult population, and recovery from it is a major health concern worldwide. The aim of the present study was to evaluate the effectiveness of citalopram on 3-mounth outcome of nondepressed acute IS patients. METHODS: In a randomized, placebo-controlled clinical trial, 144 patients with acute IS were studied for 3 months. In one group, the patients received oral citalopram 20 mg (once daily), and in the other group, they received placebo...
April 1, 2017: Neurorehabilitation and Neural Repair
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