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https://www.readbyqxmd.com/read/29169202/accessory-mitral-valve-mimicking-aortic-valve-endocarditis-as-a-cause-of-cerebrovascular-accident
#1
Benjamin C Degner, Mario Gaudino, Erin Iannacone, Christopher Lau, Leonard N Girardi
Accessory mitral valve (AMV) is a rare congenital cardiac malformation associated with left ventricular outflow tract obstruction and endocarditis. We report a patient with an AMV who presented with a cerebellar infarct and discuss the management of this anomaly.
November 23, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29169158/potential-targets-and-clinical-value-of-mir-224-5p-in-cancers-of-the-digestive-tract
#2
Lu Zhang, Lan-Shan Huang, Gang Chen, Zhen-Bo Feng
BACKGROUND/AIMS: MicroRNAs participate in various biological processes in malignant tumors. However, the mechanisms of miR-224-5p in digestive system cancers are not fully understood. A comprehensive investigation of the clinical value and potential targets of miR-224-5p in cancers of the digestive tract is necessary. METHODS: Expression profiling data and related-prognostic data of miR-224-5p were acquired from Gene Expression Omnibus, The Cancer Genome Atlas, ArrayExpress, and published literature...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169000/hidradenitis-suppurativa-and-crohn-s-disease-a-case-series
#3
S Kirthi, R Hellen, R O'Connor, M Connolly, A M Tobin, D McNamara
Hidradenitis Suppurativa (HS) is characterized by chronic recurrent abscesses, nodules and draining sinus tracts with scar formation. Cutaneous Crohn's Disease (CD) may also present similarly. We wished to identify and describe an Irish cohort with combined HS and CD, with a view to a better recognition of clinical manifestations and understanding of the pathophysiology underlying these two overlapping conditions. Cases were identified using the HIPE Code at Tallaght Hospital from 1990-2014 and retrospective review was performed...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168996/cancer-incidence-and-mortality-due-to-excess-body-weight-in-ireland-an-analysis-of-10-year-data
#4
A Collins, T McCarthy, M Laffoy
Excess body weight (EBW) increases the risk of specific cancers. The prevalence of EBW has risen significantly in Ireland over recent decades. To highlight the impact on cancer, and to inform future policies, we calculated the proportion of cancers in Ireland that were attributable to EBW using the Population Attributable Fraction (PAF). This fraction was then applied to Irish incidence and mortality data for specific cancers from 2003-2012 to estimate the number of new cancers and cancer deaths attributable to EBW...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168747/optimization-of-dissolution-compartments-in-a-biorelevant-dissolution-apparatus-golem-v2-supported-by-multivariate-analysis
#5
Ivan Stupák, Sylvie Pavloková, Jakub Vysloužil, Jiří Dohnal, Martin Čulen
Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization of dissolution compartments/vessels for an updated version of the biorelevant dissolution apparatus-Golem v2. We designed eight compartments of uniform size but different inner geometry. The dissolution performance of the compartments was tested using immediate release caffeine tablets and evaluated by standard statistical methods and principal component analysis...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29168466/new-delhi-metallo-%C3%AE-lactamase-type-carbapenemases-producing-escherichia-coli-isolates-from-hospitalized-patients-a-pilot-study
#6
Shyam Sunder Grover, Ananya Doda, Nupur Gupta, Inderjeet Gandhoke, Jyoti Batra, Charoo Hans, Shashi Khare
BACKGROUND & OBJECTIVES: Resistances to carbapenem group of antimicrobials among Escherichia coli due to production of carbapenemases, especially the New Delhi metallo-β-lactamase (NDM) types, pose serious challenges in the treatment of infections in healthcare settings. This study was undertaken to detect NDM producing E. coli isolates from hospitalized patients with urinary tract infection (UTI). METHODS: A total of 30 non-repetitive isolates of E. coli from hospitalized patients with clinical suspicion of UTI were subjected to antimicrobial susceptibility testing...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168442/seasonality-of-urinary-tract-infections-in-the-united-kingdom-in-different-age-groups-longitudinal-analysis-of-the-health-improvement-network-thin
#7
A Rosello, K B Pouwels, M Domenech DE Cellès, E VAN Kleef, A C Hayward, S Hopkins, J V Robotham, T Smieszek, L Opatowski, S R Deeny
Evidence regarding the seasonality of urinary tract infection (UTI) consultations in primary care is conflicting and methodologically poor. To our knowledge, this is the first study to determine whether this seasonality exists in the UK, identify the peak months and describe seasonality by age. The monthly number of UTI consultations (N = 992 803) and nitrofurantoin and trimethoprim prescriptions (N = 1 719 416) during 2008-2015 was extracted from The Health Improvement Network (THIN), a large nationally representative UK dataset of electronic patient records...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29168369/polyposis-deserves-a-perfect-physical-examination-for-final-diagnosis-bannayan-riley-ruvalcaba-syndrome
#8
Hayriye Hızarcıoğlu-Gülşen, Esra Kılıç, Elena Dominguez-Garrido, Yusuf Aydemir, Gülen Eda Utine, İnci Nur Saltık-Temizel
Hızarcıoğlu-Gülşen H, Kılıç E, Dominguez-Garrido E, Aydemir Y, Utine GE, Saltık-Temizel İN. Polyposis deserves a perfect physical examination for final diagnosis: Bannayan-Riley-Ruvalcaba syndrome. Turk J Pediatr 2017; 59: 80-83. Bannayan-Riley-Ruvalcaba syndrome (BRRS) is a rare autosomal dominant inherited polyposis syndrome characterized by macrocephaly, lipomatosis, hemangiomatosis, intestinal polyposis and pigmented macules on penis. The mutation of the PTEN gene that is responsible for controlling cellular proliferation, migration and apoptosis clarifies the reason of tissue overgrowth in BRRS...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29168282/risk-factors-for-asthma-occurrence-in-children-with-early-onset-atopic-dermatitis-an-8-year-follow-up-study
#9
Ching-Chun Huang, Tung-Liang Chiang, Pau-Chung Chen, Shio-Jean Lin, Hui-Ju Wen, Yue-Liang Guo
BACKGROUND: Children with early-onset atopic dermatitis (AD) are at substantial risk of developing asthma later in life, and identifying the critical window of detrimental exposure is advantageous for implementing preventive actions. The aim of this study was to evaluate the role of exposure to environmental modifiers during pregnancy and early childhood in asthma occurrence in an infantile AD cohort. METHODS: Eligible study participants were selected from the Taiwan Birth Cohort Study, which enrolled 24200 newborns in 2005...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29168235/effects-of-nutraceuticals-on-sexual-satisfaction-and-lower-urinary-tract-symptoms-in-a-cohort-of-young-old-men
#10
Anna Perri, Alessandro Ilacqua, Marina Valenti, Antonio Aversa
The aim of this study was to evaluate the effects of nutraceuticals containing multiple supplemental facts (Virherbe®/Rekupros®) on sexual satisfaction and lower urinary tract symptoms (LUTS) in young-old men. In an open-label trial, 40 males (mean age 66 ± 13) with sexual disturbances and mild LUTS but without cognitive/motor impairment and clinical hypogonadism were enrolled. Sexual desire (SD; IIEF-SD domain) and satisfaction (Global Assessment Question; GAQ), the capacity to perform daily activities (evaluated by 6-min walking test [6MWT]), and International Prostate Symptoms Scores (IPSS) were evaluated before and after oral administration of 2 capsules/day of each supplement for 8 weeks...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29168214/transdermal-light-neuromodulation-optogenetics-in-the-murine-urinary-tract
#11
Shannon L Wallace, Robert S Kelley, Shailja Mehta, Giannina Descalzi, John A Fantl, Charles Ascher-Walsh
BACKGROUND: Optogenetics is a biologic technique that uses light to control living neurons, which have been genetically modified to express light-sensitive ion-channels. OBJECTIVES: Using an adenovirus to modify the sciatic nerves of mice, we aim to demonstrate peripheral neuromodulation of bladder pain using transdermal light. STUDY DESIGN: This pilot study is divided into: A) Confirmation and Application and B) Behavioral Step. A) Six mice were injected with AAV6-hSyn-ChR2(H134R)-eYFP virus into their sciatic nerves...
November 23, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29168204/early-and-medium-term-outcomes-of-alfieri-mitral-valve-repair-in-the-management-of-systolic-anterior-motion-during-septal-myectomy
#12
Richard Collis, Oliver Watkinson, Antonis Pantazis, Maria Tome-Esteban, Perry M Elliott, Christopher G A McGregor
BACKGROUND: This report studies the early and medium-term clinical and echocardiographic outcomes of the Alfieri edge-to-edge mitral valve repair, as adjunctive therapy, to prevent and treat systolic anterior motion (SAM) at the time of septal myectomy (SM) for left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. METHODS: From 2009-2015, 11 consecutive patients had a trans-atrial Alfieri repair, to prevent (n = 7) or treat (n = 4) SAM at the time of SM...
November 23, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29168167/interdependent-feedback-regulation-of-breathing-by-the-carotid-bodies-and-the-retrotrapezoid-nucleus
#13
Patrice G Guyenet, Douglas A Bayliss, Ruth L Stornetta, Roy Kanbar, Yingtang Shi, Benjamin B Holloway, George M P R Souza, Tyler M Basting, Stephen B G Abbott, Ian C Wenker
The retrotrapezoid nucleus, RTN, regulates breathing in a CO2 and state-dependent manner. RTN neurons are glutamatergic and innervate principally the respiratory pattern generator; they regulate multiple aspects of breathing, including active expiration, and maintain breathing automaticity during non-REM sleep. RTN neurons encode arterial PCO2 /pH via cell-autonomous and paracrine mechanisms, and via input from other CO2 -responsive neurons. In short, RTN neurons are a pivotal structure for breathing automaticity and arterial PCO2 homeostasis...
November 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29167994/congenital-zika-virus-infection-a-neuropathological-review
#14
L Chimelli, E Avvad-Portari
BACKGROUND: A relationship between Zika virus (ZikV) infection in pregnancy and the occurrence of microcephaly was established during the Zika outbreak in Brazil (2015-2016). Neuropathological findings in congenital Zika syndrome helped to understand its pathogenetic mechanisms. RESULTS: The most relevant postmortem findings in the central nervous system (CNS) of fetuses and neonates infected with ZikV early in gestation are microcephaly with ex-vacuo ventriculomegaly and large head circumference associated with obstructive hydrocephalus due to severe midbrain and aqueduct distortion...
November 22, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29167892/association-of-prognostic-value-of-primary-tumor-location-in-stage-iii-colon-cancer-with-ras-and-braf-mutational-status
#15
Julien Taieb, Hampig Raphael Kourie, Jean-François Emile, Karine Le Malicot, Ralyath Balogoun, Josep Tabernero, Enrico Mini, Gunnar Folprecht, Jean-Luc Van Laethem, Claire Mulot, Olivier Bouché, Thomas Aparicio, Pierre Michel, Josef Thaler, John Bridgewater, Eric Van Cutsem, Géraldine Perkins, Come Lepage, Ramon Salazar, Pierre Laurent-Puig
Importance: We know of no data on the prognostic value of primary tumor location (PTL) according to BRAF, RAS, and microsatellite instability (MSI) status in patients who have undergone resection for colon cancer (CC) and have been treated with current standard adjuvant chemotherapy. Objective: To determine the prognostic and predictive value of PTL according to BRAF, RAS, and MSI status in patients with stage III CC receiving adjuvant treatment with FOLFOX (folinic acid [leucovorin calcium], fluorouracil, and oxaliplatin) with or without cetuximab...
November 22, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29167839/early-life-exposure-to-indoor-air-pollution-or-tobacco-smoke-and-lower-respiratory-tract-illness-and-wheezing-in-african-infants-a-longitudinal-birth-cohort-study
#16
Aneesa Vanker, Whitney Barnett, Lesley Workman, Polite M Nduru, Peter D Sly, Robert P Gie, Heather J Zar
Background: Indoor air pollution (IAP) and environmental tobacco smoke (ETS) are associated with lower respiratory tract illness (LRTI) or wheezing in children. However, the effect of the timing of these exposures, specifically antenatal versus postnatal, and of alternate fuel sources such as the increasingly used volatile organic compounds have not been well studied. We longitudinally investigated the effect of antenatal or postnatal IAP and ETS on LRTI or wheezing prevalence and severity in African infants...
November 2017: The Lancet. Planetary health
https://www.readbyqxmd.com/read/29167837/neighborhood-and-individual-sociodemographic-characteristics-associated-with-disparities-in-adult-obesity-and-perceptions-of-the-home-food-environment
#17
Michael T Halpern, Laura C Arena, Rachel A Royce, Robin E Soler, Breda Munoz, Caitlin M Hennessy
Purpose: Multiple studies have demonstrated significant disparities in the relationship between individual sociodemographic characteristics and risk of overweight or obesity. However, little information is available for assessing the complex associations among being overweight or obese with neighborhood and individual sociodemographic factors and the measured and perceived community food environment. Methods: Using 2014 national evaluation data from 20 communities (analyzed 2015-2016) that participated in the U...
2017: Health Equity
https://www.readbyqxmd.com/read/29167690/synchronous-gists-associated-with-multiple-sporadic-tumors-a-case-report
#18
Danila Comandini, Azzurra Damiani, Alessandro Pastorino
Gastrointestinal stromal tumors (GISTs) are rare neoplasms, but they also represent the most common mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal. GIST incidence ranges around 1% of all gastrointestinal malignancies. Approximately 5% of all GISTs have a hereditary etiology. The remaining 95% of GISTs are considered sporadic events, with up to 75% of cases driven by a constitutional activation of the c-KIT proto-oncogene. GISTs are generally solitary lesions. Nonetheless, multiple sporadic GISTs can occur and present as synchronous or metachronous tumors, usually associated with familial GIST...
2017: Drugs in Context
https://www.readbyqxmd.com/read/29167624/unique-ventricular-tachycardia-originating-from-the-right-bundle-branch
#19
Hongliang Yang, Daoyuan Si, Yaliang Tong, Zhe An, Ping Yang, Yuquan He
Ventricular tachycardia (VT), a common arrhythmia, frequently originates from in the right ventricular outflow tract, left ventricular outflow tract, aortic sinus, and left ventricular papillary muscle but infrequently from the His-Purkinje system, whereas the VT stemming from the right bundle branch has rarely been reported. Here we reported a case with of VT originating from the right bundle branch which was subsequently successfully treated with radiofrequency ablation and demonstrated the electrocardiac features of VT using an electrophysiological examination...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29167599/inhalable-dust-endotoxins-and-1-3-%C3%AE-d-glucans-as-indicators-of-exposure-in-waste-sorting-plant-environment
#20
Anna Kozajda, Karolina Jeżak, Marcin Cyprowski, Irena Szadkowska-Stańczyk
The aim of the study was to assess the levels of inhalable dust, endotoxins and (1-3)-β-d-glucans as agents harmful to the respiratory tract of workers of municipal waste sorting plants and interaction between these agents based on the measurements taken in two plants with different processing capacities. The study was conducted in summer season in two waste sorting plants (WSPs) differing in processing capacity. Samples of bioaerosol for inhalable dust (gravimetric method), endotoxins (LAL test in kinetic, chromogenic version) and (1-3)-β-d-glucans (Glucatell test in kinetic version) were collected from 42 sorting workers using individual aspirators with glass fiber filters during the work shift...
2017: Aerobiologia
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