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https://www.readbyqxmd.com/read/27936510/systematic-evaluation-of-cs-rosetta-for-membrane-protein-structure-prediction-with-sparse-noe-restraints
#1
Katrin Reichel, Olivier Fisette, Tatjana Braun, Olivier F Lange, Gerhard Hummer, Lars V Schäfer
We critically test and validate the CS-Rosetta methodology for de novo structure prediction of α-helical membrane proteins (MPs) from NMR data, such as chemical shifts and NOE distance restraints. By systematically reducing the number and type of NOE restraints, we focus on determining the regime in which MP structures can be reliably predicted and pinpoint the boundaries of the approach. Five MPs of known structure were used as test systems, phototaxis sensory rhodopsin II (pSRII), a subdomain of pSRII, disul_de binding protein B (DsbB), microsomal prostaglandin E2 synthase-1 (mPGES-1), and translocator protein (TSPO)...
December 9, 2016: Proteins
https://www.readbyqxmd.com/read/27936424/boar-taint-meat-quality-and-fail-rate-in-entire-male-pigs-and-male-pigs-immunized-against-gonadotrophin-releasing-factor-as-related-to-body-weight-and-feeding-regime
#2
K L Moore, B P Mullan, F R Dunshea
The objective of this experiment was to compare the pork quality of entire male pigs and pigs immunized against GnRF (IC males) at both light (64.8kg) and heavy (106kg) liveweights and two feeding regimes (restricted at 2.5 times maintenance and ad libitum). There was no difference in objective measurements (P>0.05) or eating pork quality (P>0.1) between entire male and IC males. Fail rates were reduced by 9.1% and 12% for pork from IC males for quality grade (P=0.007) and re-purchase intention (P=0.001), respectively, compared to pork from entire males...
December 2, 2016: Meat Science
https://www.readbyqxmd.com/read/27936272/uncertainty-of-sensory-signal-explains-variation-of-color-constancy
#3
Christoph Witzel, Carlijn van Alphen, Christoph Godau, J Kevin O'Regan
Color constancy is the ability to recognize the color of an object (or more generally of a surface) under different illuminations. Without color constancy, surface color as a perceptual attribute would not be meaningful in the visual environment, where illumination changes all the time. Nevertheless, it is not obvious how color constancy is possible in the light of metamer mismatching. Surfaces that produce exactly the same sensory color signal under one illumination (metamerism) may produce utterly different sensory signals under another illumination (metamer mismatching)...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27936270/the-relative-contribution-of-noise-and-adaptation-to-competition-during-tri-stable-motion-perception
#4
Andrew Isaac Meso, James Rankin, Olivier Faugeras, Pierre Kornprobst, Guillaume S Masson
Animals exploit antagonistic interactions for sensory processing and these can cause oscillations between competing states. Ambiguous sensory inputs yield such perceptual multistability. Despite numerous empirical studies using binocular rivalry or plaid pattern motion, the driving mechanisms behind the spontaneous transitions between alternatives remain unclear. In the current work, we used a tristable barber pole motion stimulus combining empirical and modeling approaches to elucidate the contributions of noise and adaptation to underlying competition...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27936122/association-of-odor-thresholds-and-responses-in-cerebral-blood-flow-of-the-prefrontal-area-during-olfactory-stimulation-in-patients-with-multiple-chemical-sensitivity
#5
Kenichi Azuma, Iwao Uchiyama, Mari Tanigawa, Ikuko Bamba, Michiyo Azuma, Hirohisa Takano, Toshikazu Yoshikawa, Kou Sakabe
Multiple chemical sensitivity (MCS) is a disorder characterized by nonspecific and recurrent symptoms from various organ systems associated with exposure to low levels of chemicals. Patients with MCS process odors differently than controls do. Previously, we suggested that this odor processing was associated with increased regional cerebral blood flow (rCBF) in the prefrontal area during olfactory stimulation using near-infrared spectroscopic (NIRS) imaging. The aim of this study was to investigate the association of odor thresholds and changes in rCBF during olfactory stimulation at odor threshold levels in patients with MCS...
2016: PloS One
https://www.readbyqxmd.com/read/27935990/hyperalgesia-and-persistent-pain-after-breast-cancer-surgery-a-prospective-randomized-controlled-trial-with-perioperative-cox-2-inhibition
#6
Noud van Helmond, Monique A Steegers, Gertie P Filippini-de Moor, Kris C Vissers, Oliver H Wilder-Smith
BACKGROUND: Persistent pain is a challenging clinical problem after breast cancer treatment. After surgery, inflammatory pain and nociceptive input from nerve injury induce central sensitization which may play a role in the genesis of persistent pain. Using quantitative sensory testing, we tested the hypothesis that adding COX-2 inhibition to standard treatment reduces hyperalgesia after breast cancer surgery. A secondary hypothesis was that patients developing persistent pain would exhibit more postoperative hyperalgesia...
2016: PloS One
https://www.readbyqxmd.com/read/27935970/sanshool-on-the-fingertip-interferes-with-vibration-detection-in-a-rapidly-adapting-ra-tactile-channel
#7
Scinob Kuroki, Nobuhiro Hagura, Shin'ya Nishida, Patrick Haggard, Junji Watanabe
An Asian spice, Szechuan pepper (sanshool), is well known for the tingling sensation it induces on the mouth and on the lips. Electrophysiological studies have revealed that its active ingredient can induce firing of mechanoreceptor fibres that typically respond to mechanical vibration. Moreover, a human behavioral study has reported that the perceived frequency of sanshool-induced tingling matches with the preferred frequency range of the tactile rapidly adapting (RA) channel, suggesting the contribution of sanshool-induced RA channel firing to its unique perceptual experience...
2016: PloS One
https://www.readbyqxmd.com/read/27935460/sensory-experience-memory-in-resource-therapy
#8
Gordon J Emmerson
A sensory experience memory (SEM) is an emotional memory that may be either connected to an intellectual memory or it may have become dissociated from its corresponding intellectual memory. Sensory experience memories are the cause of a number of pathologies, including PTSD, panic disorder, and anxiety. When a personality state that holds a negative SEM assumes the conscious, the client may display negative emotional reactions that appear unwarranted. SEMs can also play a central role in therapy to resolve pathology...
January 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/27935445/the-effects-of-sensory-manipulations-on-motor-behavior-from-basic-science-to-clinical-rehabilitation
#9
Taisei Sugiyama, Sook-Lei Liew
Modifying sensory aspects of the learning environment can influence motor behavior. Although the effects of sensory manipulations on motor behavior have been widely studied, there still remains a great deal of variability across the field in terms of how sensory information has been manipulated or applied. Here, the authors briefly review and integrate the literature from each sensory modality to gain a better understanding of how sensory manipulations can best be used to enhance motor behavior. Then, they discuss 2 emerging themes from this literature that are important for translating sensory manipulation research into effective interventions...
December 9, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27935438/assessing-proprioception-in-children-a-review
#10
Virginia Way Tong Chu
Proprioception is the subconscious and conscious awareness of the spatial and mechanical status of the musculoskeletal framework. When working with children with motor delays and sensory integrative dysfunction, occupational therapists routinely assess the client's proprioceptive system. However, currently available assessments for occupational therapists are primarily observer-based and concerns have been raised about the reliability of observer-based assessments of sensation. The author's purpose was to review measures of proprioception currently available to occupational therapists and explore direct measures of proprioception from neuroscience and rehabilitation that can be adapted for pediatric clinical use...
December 9, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27935069/nerve-ultrasound-abnormalities-mirror-the-course-of-vzv-sensory-motor-radiculoplexopathy
#11
Alessandro Salvalaggio, Mario Cacciavillani, Andrea Visentin, Marta Campagnolo, Livio Trentin, Chiara Briani
No abstract text is available yet for this article.
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27934976/influence-of-double-w1-o-w2-emulsion-composition-on-lubrication-properties
#12
A K L Oppermann, L C Verkaaik, M Stieger, E Scholten
Double (w1/o/w2) emulsions are potential fat replacers in foods. Fats are known for their lubricating properties, which contribute to texture perception. It is therefore of interest to understand how the composition of double emulsions influences lubrication properties. This study focuses on the understanding of the influence of the fraction of inner dispersed aqueous phase w1 and the gelation of the w1 droplets on the lubrication properties of double emulsions. The addition of an inner water phase w1 to the oil droplets decreased friction at low entrainment speeds due to adsorption of the lipophilic emulsifier polyglycerol polyricinoleate (PGPR) at the hydrophobic tribo-surface...
December 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27934777/rodent-model-for-assessing-the-long-term-safety-and-performance-of-peripheral-nerve-recording-electrodes
#13
Srikanth Vasudevan, Kunal Patel, Cristin Welle
OBJECTIVE: In the US alone, there are approximately 185 000 cases of limb amputation annually, which can reduce the quality of life for those individuals. Current prosthesis technology could be improved by access to signals from the nervous system for intuitive prosthesis control. After amputation, residual peripheral nerves continue to convey motor signals and electrical stimulation of these nerves can elicit sensory percepts. However, current technology for extracting information directly from peripheral nerves has limited chronic reliability, and novel approaches must be vetted to ensure safe long-term use...
December 9, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27933866/identification-of-hydrogen-disulfanes-and-hydrogen-trisulfanes-in-h2s-bottle-in-flint-and-in-dry-mineral-white-wine
#14
Christian Starkenmann, Charles Jean-Francois Chappuis, Yvan Niclass, Pascale Deneulin
Through the accidental contamination of a gas cylinder of H2S, the importance of polysulfanes for flint, gun powder, and match odors was discovered. The hydrogen disulfane was prepared from disulfanediylbis[methyl(diphenyl)silane], and its odor descriptor was evaluated in the gas phase from a gas chromatograph coupled to an olfaction port. The occurrence of this compound in flint and pebbles was confirmed by analyses after derivatization with pentafluorobromobenzene. The occurrence of this sulfane was also confirmed in two dry white Swiss Chasselas wines, sorted by a large-scale sensory analysis from 80 bottles and evaluated by 62 wine professionals...
November 30, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933285/developmental-profile-and-diagnoses-in-children-presenting-with-motor-stereotypies
#15
Francesco Cardona, Francesca Valente, Daniela Miraglia, Caterina D'Ardia, Valentina Baglioni, Flavia Chiarotti
INTRODUCTION: Motor stereotypies represent a typical example of the difficulty in distinguishing non-clinical behaviors (physiological and transient) from symptoms or among different disorders ["primary stereotypies," associated with autistic spectrum disorder (ASD), intellectual disabilities, genetic syndromes, and sensory impairment]. The aim of this study was to obtain an accurate assessment on the relationship between stereotypies and neurodevelopmental disorders. METHODS: We studied 23 children (3 girls), aged 36-95 months, who requested a consultation due to the persistence or increased severity of motor stereotypies...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27933259/deformity-correction-and-extremity-lengthening-in-the-lower-leg-comparison-of-clinical-outcomes-with-two-external-surgical-procedures
#16
Eugen Reitenbach, Robert Rödl, Georg Gosheger, Björn Vogt, Frank Schiedel
OBJECTIVE: Distraction osteogenesis is a method of stimulating the growth of new bone tissue in order to lengthen the extremities or bridge resected bone defects. In addition to the now-established intramedullary procedures, two different fixator systems are in use. The present study investigated the classical Ilizarov ring fixator (IRF) and a hexapod to assess the precision of lower-leg lengthening and complications classified using the Paley criteria for problems, obstacles, and complications...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933164/effect-of-elevated-carbon-dioxide-on-shoal-familiarity-and-metabolism-in-a-coral-reef-fish
#17
Lauren E Nadler, Shaun S Killen, Mark I McCormick, Sue-Ann Watson, Philip L Munday
Atmospheric CO2 is expected to more than double by the end of the century. The resulting changes in ocean chemistry will affect the behaviour, sensory systems and physiology of a range of fish species. Although a number of past studies have examined effects of CO2 in gregarious fishes, most have assessed individuals in social isolation, which can alter individual behaviour and metabolism in social species. Within social groups, a learned familiarity can develop following a prolonged period of interaction between individuals, with fishes preferentially associating with familiar conspecifics because of benefits such as improved social learning and greater foraging opportunities...
2016: Conservation Physiology
https://www.readbyqxmd.com/read/27932964/temporary-nerve-block-at-selected-digits-revealed-hand-motor-deficits-in-grasping-tasks
#18
Aude Carteron, Kerry McPartlan, Christina Gioeli, Emily Reid, Matt Turturro, Barry Hahn, Cynthia Benson, Wei Zhang
Peripheral sensory feedback plays a crucial role in ensuring correct motor execution throughout hand grasp control. Previous studies utilized local anesthesia to deprive somatosensory feedback in the digits or hand, observations included sensorimotor deficits at both corticospinal and peripheral levels. However, the questions of how the disturbed and intact sensory input integrate and interact with each other to assist the motor program execution, and whether the motor coordination based on motor output variability between affected and non-affected elements (e...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27932963/distinct-neural-substrates-for-maintaining-locations-and-spatial-relations-in-working-memory
#19
Kara J Blacker, Susan M Courtney
Previous work has demonstrated a distinction between maintenance of two types of spatial information in working memory (WM): spatial locations and spatial relations. While a body of work has investigated the neural mechanisms of sensory-based information like spatial locations, little is known about how spatial relations are maintained in WM. In two experiments, we used fMRI to investigate the involvement of early visual cortex in the maintenance of spatial relations in WM. In both experiments, we found less quadrant-specific BOLD activity in visual cortex when a single spatial relation, compared to a single spatial location, was held in WM...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27932960/noise-improves-visual-motion-discrimination-via-a-stochastic-resonance-like-phenomenon
#20
Mario Treviño, Braniff De la Torre-Valdovinos, Elias Manjarrez
The stochastic resonance (SR) is a phenomenon in which adding a moderate amount of noise can improve the signal-to-noise ratio and performance of non-linear systems. SR occurs in all sensory modalities including the visual system in which noise can enhance contrast detection sensitivity and the perception of ambiguous figures embedded in static scenes. Here, we explored how adding background white pixel-noise to a random dot motion (RDM) stimulus produced changes in visual motion discrimination in healthy human adults...
2016: Frontiers in Human Neuroscience
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