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https://www.readbyqxmd.com/read/29465585/occurrence-of-signet-ring-cell-carcinoma-with-cholangiocarcinoma-25-years-after-choledochal-cyst-excision-a-case-report
#1
Conggui Zhang, Jianpeng Zhou, Kai Kou, Shouling Liu, Feng We, Guangyi Wang
RATIONALE: Choledochal cysts are a risk factor for the development of cholangiocarcinoma. Hence, complete surgical excision is the preferred treatment in most cases. However, cholangiocarcinoma still can develop from the remnant biliary system after surgical excision. Signet-ring cell carcinoma is a rare type of cancer of the biliary system, and the occurrence of signet-ring cell carcinoma after surgical excision of choledochal cysts has not been reported in the English literature to date...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464885/effect-of-roux-en-y-gastric-bypass-on-liver-mitochondrial-dynamics-in-a-rat-model-of-obesity
#2
Jessica Sacks, Anny Mulya, Ciaran E Fealy, Hazel Huang, John D Mosinski, Mangesh R Pagadala, Hideharu Shimizu, Esam Batayyah, Philip R Schauer, Stacy A Brethauer, John P Kirwan
Bariatric surgery provides significant and durable improvements in glycemic control and hepatic steatosis, but the underlying mechanisms that drive improvements in these metabolic parameters remain to be fully elucidated. Recently, alterations in mitochondrial morphology have shown a direct link to nutrient adaptations in obesity. Here, we evaluate the effects of Roux-en-Y gastric bypass (RYGB) surgery on markers of liver mitochondrial dynamics in a diet-induced obesity Sprague-Dawley (SD) rat model. Livers were harvested from adult male SD rats 90-days after either Sham or RYGB surgery and continuous high-fat feeding...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29464866/biliary-stricture-due-to-a-migrated-suture-after-laparoscopic-distal-gastrectomy
#3
Takehiro Noji, Yo Kurashima, Yoshitsugu Nakanishi, Toshimichi Asano, Yuma Ebihara, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Tomoko Mitsuhashi, Satoshi Hirano
Benign biliary strictures have a broad spectrum of etiologies. There have been no reported cases, however, of a biliary stricture secondary to a migrated suture after laparoscopic distal gastrectomy (LDG). Here, we report one such case. The patient was a 60-year-old man who underwent LDG with Roux-en-Y reconstruction for early gastric cancer. Pathology revealed early cancer (T1N0M0) with a curative resection. Two years after LDG, the patient was found to have elevated hepatobiliary enzymes. After further workup, the new diagnosis was invasive cholangiocarcinoma (T2N0M0), and the patient underwent pancreaticoduodenectomy...
February 20, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29462566/non-alcoholic-fatty-liver-disease-and-gastric-bypass-surgery-regulate-serum-and-hepatic-levels-of-pyruvate-kinase-isoenzyme-m2
#4
Luca Meoli, Nitin K Gupta, Nima Saeidi, Courtney Panciotti, Sudha B Biddinger, Kathleen E Corey, Nicholas Stylopoulos
Treatment of non-alcoholic fatty liver disease (NAFLD) focuses on the underlying metabolic syndrome, and Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective options. In rodents and human patients, RYGB induces an increase in the gene and protein expression levels of the M2 isoenzyme of Pyruvate Kinase (PKM2) in the jejunum. Since PKM2 can be secreted in the circulation, our hypothesis was that the circulating levels of PKM2 increase after RYGB. Our data, however, revealed an unexpected finding and a potential new role of PKM2 for the natural history of metabolic syndrome and NAFLD...
February 20, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29460379/5-years-long-term-clinical-outcome-after-bariatric-surgery-a-multi-ethnic-asian-population-in-singapore
#5
B C Toh, W H Chan, Akh Eng, Ekw Lim, C H Lim, K W Tham, S Fook-Chong, Jth Tan
Bariatric surgery is an effective treatment for morbid obesity and its metabolic related comorbidities - Type II Diabetes, Hypertension and Hyperlipidaemia.1 However, the literature is scarce regarding the long-term outcome after bariatric surgery especially among multi-ethnic Asian populations. Considering the growing number of bariatric metabolic operations in Asia, we have attempted to provide a regional perspective on 5-year long-term clinical outcomes post bariatric surgery in Singapore. Between years 2010 to 2016, all bariatric operative cases consisted of 393 Laparoscopic Sleeve Gastrectomy (LSG), 125 Laparoscopic Roux-En-Y Gastric Bypass (RYGB) and 43 Laparoscopic Mini-gastric Bypass (MGB) were included...
February 20, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29459613/complete-annular-pancreas-with-concurrent-entero-pancreatico-biliary-symptoms-in-adult-a-case-report
#6
M M Chowdhury, A A Ullah, R Karim, A Ahmed, S Mohammed, S A Sobhan, A A Farmidi, F Zuwaida, R Pradan, R Mahmud, B Rai, S Pervin, R Habib
Complete Annular pancreas (AP) is a rare congenital anomaly, often presented and operated at the early age of life. Adult presentation group usually presents with either biliary or duodenal or pancreatic symptoms. We report a case of 43 years old female presenting with concurrent enteric, biliary and pancreatic symptoms admitted on April 2016 in Hepatobiliary and Pancreatic Surgery Department of BSMMU, Dhaka, Bangladesh. A complete type of annular pancreas with partial duodenal stenosis and dilated common bile duct was observed during laparotomy...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29459013/the-family-coriobacteriaceae-is-a-potential-contributor-to-the-beneficial-effects-of-roux-en-y-gastric-bypass-on-type-2-diabetes
#7
Haijun Liu, Hong Zhang, Xiao Wang, Xuemei Yu, Cheng Hu, Xueli Zhang
BACKGROUND: Changes in gut microbiota induced by bariatric surgery have been associated with metabolic benefits. OBJECTIVES: Our aim was to identify specific gut microbiota that may contribute to the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB). SETTING: Laboratories of Shanghai Diabetes Institute and Shanghai Sixth People's Hospital. METHODS: Diabetic rats induced via a high-fat diet and low-dose streptozotocin administration were randomized to RYGB or sham surgery, and stool samples were collected at baseline and at postoperative week 8...
January 17, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29455407/a-single-center-experience-examining-the-length-of-stay-and-safety-of-early-discharge-after-laparoscopic-roux-en-y-gastric-bypass-surgery
#8
Melanie H Howell, Aaron Praiss, Dina Podolsky, Natan Zundel, Erin Moran-Atkin, Jenny J Choi, Diego R Camacho
PURPOSE: This study's objective was to describe our experience and evaluate the safety of early discharge (ED) following laparoscopic Roux-en-Y gastric bypass (LRYGB) in a specific patient population. MATERIALS AND METHODS: Patients undergoing LRYGB at Montefiore Medical Center were retrospectively reviewed. Patients readmitted in the first 30 days following surgery were compared to those patients who were not readmitted. Data analysis was used to compare groups and to determine factors associated with readmission...
February 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29455405/bariatric-surgery-in-patients-on-chronic-anticoagulation-therapy
#9
Gautam Sharma, Zubaidah Nor Hanipah, Ali Aminian, Suriya Punchai, Emre Bucak, Philip R Schauer, Stacy A Brethauer
BACKGROUND: Perioperative management of chronically anti-coagulated patients undergoing bariatric surgery requires a balance of managing hemorrhagic and thromboembolic risks. The aim of this study is to evaluate the incidence of hemorrhagic complications and their management in chronically anticoagulated (CAT) patients undergoing bariatric surgery. METHODS: A retrospective review of CAT patients undergoing bariatric surgery at an academic center from 2008 to 2015 was studied...
February 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29454535/insurance-mandated-preoperative-diet-and-outcomes-after-bariatric-surgery
#10
Charles J Keith, Lauren E Goss, Camille D Blackledge, Richard D Stahl, Jayleen Grams
BACKGROUND: Despite a lack of demonstrated patient benefit, many insurance providers mandate a physician-supervised diet before financial coverage for bariatric surgery. OBJECTIVES: To compare weight loss between patients with versus without insurance mandating a preoperative diet. SETTING: University hospital, United States. METHODS: Retrospective study of all patients who underwent laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy over a 5-year period, stratified based on whether an insurance-mandated physician-supervised diet was required...
February 2, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29453461/roux-en-y-gastric-bypass-and-sleeve-gastrectomy-induces-specific-shifts-of-the-gut-microbiota-without-altering-the-metabolism-of-bile-acids-in-the-intestinal-lumen
#11
Henri Duboc, Caroline Chong Nguyen, Jean-Baptiste Cavin, Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Dominique Rainteau, Lydie Humbert, Benoit Coffin, Maude Le Gall, André Bado, Harry Sokol
Some shifts in the gut microbiota composition and its metabolic fingerprints have been associated to Sleeve gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB). So far, plasma bile acids have been associated with post-operative glucose improvement and weight loss, but nothing is known about their metabolism in the gut lumen. As bile acids are physiologically transformed by the microbiota into various species, the aim of this work was to study how SG and RYGB-associated dysbiosis impact the bioconversion of bile acids in the intestinal lumen...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29450656/laparoscopic-subtotal-gastrectomy-in-morbid-obese-patients-a-valid-option-to-laparoscopic-gastric-bypass-in-particular-circumstances-prospective-study
#12
Italo Braghetto, Gustavo Martinez, Owen Korn, Marcelo Zamorano, Enrique Lanzarini, Enrique Narbona
BACKGROUND: Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) without resection of the distal stomach is largely performed over the world for morbid obesity. Potential risk of gastric remnant carcinoma development has been suggested. PURPOSE: To present the results obtained after LRYGB with resection of distal stomach. METHOD: This prospective study includes 400 consecutive patients. The mean body weight was 105.9 ± 16.8 Kg (range 83-145 kg), and body mass index (BMI) was 38...
February 15, 2018: Surgery Today
https://www.readbyqxmd.com/read/29449181/roux-en-y-gastric-bypass-hypoglycemia-resolves-with-gastric-feeding-or-reversal-confirming-a-non-pancreatic-etiology
#13
Dawn Belt Davis, Jad Khoraki, Martynas Ziemelis, Sirinart Sirinvaravong, Jee Young Han, Guilherme M Campos
OBJECTIVE: Postprandial hypoglycemia is an infrequent but disabling complication of Roux-en-Y gastric bypass (RYGB) surgery. Controversy still exists as to whether the postprandial hyperinsulinemia observed is due to inherent changes in pancreatic β-cell mass or function or to reversible alterations caused by RYGB anatomy. We aimed to determine if gastric feeding or reversal of RYGB would normalize postprandial glucose and hormone excursions in patients with symptomatic hypoglycemia...
January 31, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29435811/comparative-outcomes-of-bariatric-surgery-in-patients-with-impaired-mobility-and-ambulatory-population
#14
Gautam Sharma, Zubaidah Nor-Hanipah, Ivy N Haskins, Suriya Punchai, Andrew T Strong, Chao Tu, John H Rodriguez, Phillip R Schauer, Matthew Kroh
PURPOSE: This study aims to characterize complications, metabolic improvement, and change in ambulation status for patients with impaired mobility undergoing bariatric surgery. MATERIAL AND METHODS: Individuals undergoing primary sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) from February 2008 to December 2015 were included. Impaired mobility (WC) was defined as using a wheelchair or motorized scooter for at least part of a typical day. The WC group was propensity score matched to ambulatory patients (1:5 ratio)...
February 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29435755/surgical-management-of-gastroesophageal-reflux-disease-in-patients-with-systemic-sclerosis
#15
Jingliang Yan, Andrew T Strong, Gautam Sharma, Scott Gabbard, Prashanti Thota, John Rodriguez, Matthew Kroh
BACKGROUND: Systemic sclerosis (scleroderma) is frequently associated with both gastroesophageal reflux disease (GERD) and simultaneous esophageal dysmotility. Anti-reflux procedures in this patient population must account for the existing physiology of each patient and likely disease progression. We aim to compare perioperative and intermediate outcomes of fundoplication versus gastric bypass for the treatment of GERD. METHODS: After IRB approval, patients with systemic sclerosis undergoing fundoplication or gastric bypass for the treatment of GERD from 2004 to 2016 were identified...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435660/indications-for-total-esophagogastric-dissociation-in-children-with-gastroesophageal-reflux-disease
#16
REVIEW
Yujiro Tanaka, Takahisa Tainaka, Hiroo Uchida
Total esophagogastric dissociation (TED) is used to treat gastroesophageal reflux (GER) after failed fundoplication in neurologically impaired patients. It is now performed for some otherwise healthy patients with severe GER. In this procedure, the gastrointestinal tract is reconstructed in a non-physiological way with a Roux-en-Y esophagojejunal anastomosis and jejuno-jejunostomy. Although TED eliminates almost all GER, some patients experience late complications. In this review, we investigated the long-term outcomes after TED to determine the best indications...
February 12, 2018: Surgery Today
https://www.readbyqxmd.com/read/29432125/clinical-and-patient-centered-outcomes-in-obese-type-2-diabetes-patients-3-years-after-randomization-to-roux-en-y-gastric-bypass-surgery-versus-intensive-lifestyle-management-the-slimm-t2d-study
#17
Donald C Simonson, Florencia Halperin, Kathleen Foster, Ashley Vernon, Allison B Goldfine
OBJECTIVE: To compare the effect of Roux-en-Y gastric bypass (RYGB) surgery versus intensive medical diabetes and weight management (IMWM) on clinical and patient-reported outcomes in obese patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We prospectively randomized 38 obese patients with T2D (15 male and 23 female, with mean ± SD weight 104 ± 16 kg, BMI 36.3 ± 3.4 kg/m2, age 52 ± 6 years, and HbA1c 8.5 ± 1.3% [69 ± 14 mmol/mol]) to laparoscopic RYGB (n = 19) or IMWM (n = 19)...
February 6, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29428999/prospective-evaluation-of-insulin-and-incretin-dynamics-in-obese-adults-with-and-without-diabetes-for-2-years-after-roux-en-y-gastric-bypass
#18
Jonathan Q Purnell, Geoffrey S Johnson, Abdus S Wahed, Chiara Dalla Man, Francesca Piccinini, Claudio Cobelli, Ronald L Prigeon, Bret H Goodpaster, David E Kelley, Myrlene A Staten, Karen E Foster-Schubert, David E Cummings, David R Flum, Anita P Courcoulas, Peter J Havel, Bruce M Wolfe
AIMS/HYPOTHESIS: In this prospective case-control study we tested the hypothesis that, while long-term improvements in insulin sensitivity (S I ) accompanying weight loss after Roux-en-Y gastric bypass (RYGB) would be similar in obese individuals with and without type 2 diabetes mellitus, stimulated-islet-cell insulin responses would differ, increasing (recovering) in those with diabetes but decreasing in those without. We investigated whether these changes would occur in conjunction with favourable alterations in meal-related gut hormone secretion and insulin processing...
February 10, 2018: Diabetologia
https://www.readbyqxmd.com/read/29428692/routine-contrast-imaging-after-bariatric-surgery-and-the-effect-on-hospital-length-of-stay
#19
Uzma Rahman, Salvatore Docimo, Aurora D Pryor, Andrew Bates, Nabeel R Obeid, Konstantinos Spaniolas
BACKGROUND: Although multiple studies demonstrate that routine postoperative contrast studies have a low yield in diagnosing patients with early gastrointestinal (GI) leak after bariatric surgery, the practice pattern is unknown. Additionally, routine imaging may hinder procedural pathways that lead to accelerated postoperative discharge. OBJECTIVES: To report on the nationwide use of routine upper GI studies (UGI) and evaluate the effect on hospital resource utilization...
January 3, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29428234/same-day-discharge-after-laparoscopic-roux-en-y-gastric-bypass-an-analysis-of-the-mbsaqip-database
#20
Colette S Inaba, Christina Y Koh, Sarath Sujatha-Bhaskar, Lishi Zhang, Ninh T Nguyen
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) has been performed with successful discharge on postoperative day 1 (POD1). There are limited studies on same-day discharge after LRYGB. The objective of this study was to examine the frequency and outcomes of same-day discharge after LRYGB. STUDY DESIGN: The 2015 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database was analyzed for adult patients who underwent elective LRYGB cases with same-day versus POD1 discharge...
February 8, 2018: Journal of the American College of Surgeons
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