Toui Tsuchiya, Shinji Nakamura, Yuichiro Sugiyama, Yasuhiro Nakao, Tsutomu Mitsuie, Kota Inoue, Eri Inoue, Yinmon Htun, Makoto Arioka, Kenichi Ohta, Hirosuke Morita, Noriko Fuke, Sonoko Kondo, Kosuke Koyano, Takanori Miki, Masaki Ueno, Takashi Kusaka
BACKGROUND: We previously reported that hydrogen (H2 ) gas combined with therapeutic hypothermia (TH) improved short-term neurological outcomes in asphyxiated piglets. However, the effect on seizure burden was unclear. Using amplitude-integrated electroencephalography (aEEG), we compared TH + H2 with TH alone in piglets 24 h after hypoxic-ischemic (HI) insult. METHODS: After a 40-min insult and resuscitation, 36 piglets ≤24 h old were divided into three groups: normothermia (NT, n = 14), TH alone (33...
January 24, 2024: Pediatric Research