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https://www.readbyqxmd.com/read/29346829/intraoperative-seizures-in-awake-craniotomy-for-perirolandic-glioma-resections-that-undergo-cortical-mapping
#1
Chikezie Ikechukwu Eseonu, Jordina Rincon-Torroella, Young M Lee, Karim ReFaey, Punita Tripathi, Alfredo Quinones-Hinojosa
BACKGROUND:  Perirolandic motor area gliomas present invasive eloquent region tumors within the precentral gyrus that are difficult to resect without causing neurologic deficits. STUDY AIMS:  This study evaluates the role of awake craniotomy and motor mapping on neurologic outcome and extent of resection (EOR) of tumor in the perirolandic motor region. It also analyzes preoperative risk factors for intraoperative seizures. METHODS:  We evaluated 57 patients who underwent an awake craniotomy for a perirolandic motor area eloquent region glioma...
January 18, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29346606/characteristics-of-cases-with-repeated-sexually-transmitted-infections-massachusetts-2014-2016
#2
Katherine K Hsu, Lauren E Molotnikov, Kathleen A Roosevelt, Heather R Elder, R Monina Klevens, Alfred DeMaria, Sevgi O Aral
Background: Persons with prior sexually transmitted infections (STIs) are at high risk for re-infection. No recent studies have examined the frequency with which persons within a geographic area are diagnosed and reported with multiple bacterial STIs over time. Methods: We conducted a retrospective, population-based study of confirmed syphilis, gonorrhea, and chlamydial infections reported to the Massachusetts state surveillance system within a two-year period, July 28, 2014 - July 27, 2016...
January 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29346080/new-insight-into-the-action-of-tryptanthrins-against-plasmodium-falciparum-pharmacophore-identification-via-a-novel-submolecular-qsar-descriptor
#3
Joel A Olson, Raymond J Terryn, Elizabeth L Stewart, J Clayton Baum, Mark J Novak
A new submolecular quantitative structure activity relationship (QSAR) descriptor was applied toward elucidating the anti-malarial pharmacophore of tryptanthrins, a class of compounds known for their anti-parasitic activities. The new descriptor is based on experimental and computational measurements of the tunneling barriers of individual lobes of the molecular orbitals. Lobe-by-lobe QSAR correlation plots revealed a single lobe of the LUMO to be strongly associated with tryptanthrin's anti-malarial activity...
December 27, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29345513/no-benefit-in-neurologic-outcomes-of-survivors-of-out-of-hospital-cardiac-arrest-with-mechanical-compression-device
#4
Ryan Newberry, Ted Redman, Elliot Ross, Rachel Ely, Clayton Saidler, Allyson Arana, David Wampler, David Miramontes
INTRODUCTION: Out-of-hospital cardiac arrest (OHCA) is a major cause of death and morbidity in the United States. Quality cardiopulmonary resuscitation (CPR) has proven to be a key factor in improving survival. The aim of our study was to investigate the outcomes of OHCA when mechanical CPR (LUCAS 2 Chest Compression System™) was utilized compared to conventional CPR. Although controlled trials have not demonstrated a survival benefit to the routine use of mechanical CPR devices, there continues to be an interest for their use in OHCA...
January 18, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29342955/pharmacokinetics-of-schizandrin-and-its-pharmaceutical-products-assessed-using-a-validated-lc-ms-ms-method
#5
Chi-Lin Li, Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
Schisandra chinensis has been used as an important component in various prescriptions in traditional Chinese medicine and, more recently, in Western-based medicine for its anti-hepatotoxic effect. The aim of this study was to develop a selective, rapid, and sensitive ultra-performance liquid chromatography-tandem mass spectrometry method for pharmacokinetic studies of schizandrin in rats. Liquid-liquid extraction was used for plasma sample preparation. A UHPLC reverse-phase C18e column (100 mm × 2.1 mm, 2 μm) coupled with a mobile phase of methanol-0...
January 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29340259/relationships-between-road-distance-to-primary-care-facilities-and-ischemic-heart-disease-and-stroke-mortality-in-hokkaido-japan-a-bayesian-hierarchical-approach-to-ecological-count-data
#6
Yasuaki Saijo, Eiji Yoshioka, Yasuyuki Kawanishi, Yoshihiko Nakagi, Sharon J B Hanley, Takahiko Yoshida
Objective: Poor access to a primary care physician may lead to poor control of risk factors for disease. This study investigated whether geographic access to a primary care physician was related to ischemic heart disease and stroke mortality. Methods: Road-distances from the centroids of the basic unit blocks of the 2010 Japanese Census to the nearest primary care facilities in Hokkaido, northern Japan, were measured using geographic information system (GIS) software...
January 2018: Journal of General and Family Medicine
https://www.readbyqxmd.com/read/29337687/comparison-of-the-solid-phase-and-liquid-liquid-extraction-methods-for-methadone-determination-in-human-serum-and-whole-blood-samples-using-gas-chromatography-mass-spectrometry
#7
Maja Veršić Bratinčević, Tanja Visković, Davorka Sutlović
The aim of this study was to determine the optimal biological sample and the optimal extraction technique for monitoring methadone concentrations in biological samples. We analysed methadone in serum and whole blood samples using gas chromatography/mass spectrometry (GC/MS). Before analysis, we compared five solid-phase extraction (SPE) and two liquid-liquid extraction (LLE) methods and determined that SPE with Supelco LC-18 in serum yielded the best extraction efficiency. The limit of detection was 10 ng mL-1 and the limit of quantification 25 ng mL-1...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337671/spectrophotometric-method-for-simultaneous-determination-of-valsartan-and-substances-from-the-group-of-statins-in-binary-mixtures
#8
Mariusz Stolarczyk, Anna Apola, Anna Maślanka, Anna Kwiecień, Włodzimierz Opoka
Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29336846/sex-differences-in-prevalence-of-emergency-department-patient-substance-use
#9
Robert D Cannon, Gillian A Beauchamp, Paige Roth, Jennifer Stephens, David B Burmeister, David M Richardson, Alanna M Balbi, Tennessee D Park, Stephen W Dusza, Marna Rayl Greenberg
PURPOSE: Substance use and misuse is prevalent in emergency department (ED) populations. While the prevalence of substance use and misuse is reported, sex-specific trends in ED populations have not been documented. We set out to determine the sex-specific prevalence of ED patient substance use during this current epidemic. METHODS: A retrospective electronic data abstraction tool, developed for quality-improvement purposes, was used to assess ED visits in 3 hospitals in northeastern Pennsylvania...
January 11, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29335780/a-comparison-of-semi-automated-volumetric-vs-linear-measurement-of-small-vestibular-schwannomas
#10
Samuel MacKeith, Tilak Das, Martin Graves, Andrew Patterson, Neil Donnelly, Richard Mannion, Patrick Axon, James Tysome
OBJECTIVE: Accurate and precise measurement of vestibular schwannoma (VS) size is key to clinical management decisions. Linear measurements are used in routine clinical practice but are prone to measurement error. This study aims to compare a semi-automated volume segmentation tool against standard linear method for measuring small VS. This study also examines whether oblique tumour orientation can contribute to linear measurement error. STUDY DESIGN: Experimental comparison of observer agreement using two measurement techniques...
January 15, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29331919/removal-of-pharmaceutical-pollutants-from-synthetic-wastewater-using-chemically-modified-biomass-of-green-alga-scenedesmus-obliquus
#11
Mohamed E M Ali, Azza M Abd El-Aty, Mohamed I Badawy, Rizka K Ali
Pharmaceutical compounds are considered emerging environmental pollutants that have a potential harmful impact on environment and human health. In this study, the biomass of alga (Scenedesmus obliquus) was modified using alkaline solution, and used for the biosorption of tramadol (TRAM) and other pharmaceuticals. The adsorption kinetics and isotherms were investigated. The obtained results reveal high adsorption capacity of tramadol over modified algal biomass (MAB) after 45min with removal percentage of 91%...
January 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29331256/measuring-non-administration-of-ordered-medications-in-the-pediatric-inpatient-setting
#12
Haresh L Bhatia, Neal R Patel, Catherine H Ivory, Phillip W Stewart, Kim M Unertl, Christoph U Lehmann
OBJECTIVE: Medication compliance in inpatient settings shows some significant gaps for adult patients. In pediatric settings prescribing and other administration errors have been studied but missed doses have not been specifically studied in the pediatric inpatient setting. We intended to apply health information technology and data processing methods to study the medication compliance for pediatric patients at our institution. STUDY DESIGN: We collected medication ordering, dispensing, and administration data spanning 42 months (7/1/2010 through 12/31/2013) for pediatric inpatients admitted to a major tertiary pediatric hospital...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29327210/paired-blood-cultures-increase-the-sensitivity-for-detecting-pathogens-in-both-inpatients-and-outpatients
#13
Bansidhar Tarai, Dinesh Jain, Poonam Das, Sandeeep Budhiraja
The objective of this study was to show the differences between paired blood cultures (PBC) versus single blood cultures (SBC) in the microbiologic yield, the sensitivity to detect pathogens and the time to positivity (TTP). We performed a retrospective study examining 112,570 blood culture samples over a 5-year period from July 2011 to May 2016 in the BacT/ALERT® 3D automated blood culture system (bioMérieux, Marcy l'Etoile, France). Bacteria and yeasts were identified using the VITEK® 2 Compact system (bioMérieux, Marcy l'Etoile, France)...
January 11, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29325186/qualitative-and-quantitative-radiological-measures-of-fracture-healing
#14
John R Field, Greg R Ruthenbeck
The formulation of appropriate postoperative strategies, following fracture repair, currently involves an understanding of radiological and clinical outcome measures. This study has evaluated several modalities used to assess the progression of bone healing in a sheep tibial segmental defect model. Measures of defect optical density and volumetric data including bone density (BD), bone volume (BV) and bone mass (BM) were compared with qualitative data involving visual appraisal of radiographs [% bridging callus and modified radiographic union score tibia (mRUST)] and a clinical outcome measure (locomotory function)...
January 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29322967/alternative-bibliometrics-from-the-web-of-knowledge-surpasses-the-impact-factor-in-a-2-year-ahead-annual-citation-calculation-linear-mixed-design-models-analysis-of-neuroscience-journals
#15
Araceli Diaz-Ruiz, Ulises Orbe-Arteaga, Camilo Rios, Ernesto Roldan-Valadez
CONTEXT: The decision about which journal to choose for the publication of research deserves further investigation. AIMS: In this study, we evaluate the predictive ability of seven bibliometrics in the Web of Knowledge to calculate total cites over a 7-year period in neuroscience journals. SETTINGS AND DESIGN: Coincidental bibliometrics appearing during 2007, 2008, 2009, 2010, and 2011, along with their corresponding cites in 2009, 2010, 2011, 2012, and 2013, were recorded from the journal citation reports (JCR) Science Edition...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322164/efficacy-of-transdermal-estradiol-and-micronized-progesterone-in-the-prevention-of-depressive-symptoms-in-the-menopause-transition-a-randomized-clinical-trial
#16
Jennifer L Gordon, David R Rubinow, Tory A Eisenlohr-Moul, Kai Xia, Peter J Schmidt, Susan S Girdler
Importance: The menopause transition and early postmenopausal period are associated with a 2- to 4-fold increased risk for clinically significant depressive symptoms. Although a few studies suggest that hormone therapy can effectively manage existing depression during this time, to our knowledge, there have been no studies testing whether hormone therapy can prevent the onset of perimenopausal and early postmenopausal depressive symptoms. Objective: To examine the efficacy of transdermal estradiol plus intermittent micronized progesterone (TE+IMP) in preventing depressive symptom onset among initially euthymic perimenopausal and early postmenopausal women...
January 10, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29321414/the-platelet-count-can-predict-in-hospital-death-in-hiv-negative-smear-positive-pulmonary-tuberculosis-inpatients
#17
Hideto Goto, Nobuyuki Horita, Ken Tashiro, Kenjiro Nagai, Masaki Yamamoto, Takashi Sato, Yu Hara, Hideyuki Nagakura, Yuji Shibata, Hiroki Watanabe, Kentaro Nakashima, Ryota Ushio, Akimichi Nagashima, Misako Ikeda, Atsuya Narita, Katsuhito Sasaki, Nobuaki Kobayashi, Makoto Kudo, Takeshi Kaneko
Introduction This retrospective cohort study investigated whether the three components of the blood cell count have prognostic implications in HIV-negative Japanese adult inpatients with smear-positive pulmonary tuberculosis. Methods We reviewed patients who were treated by the isoniazid, rifampicin, pyrazinamide, and ethambutol regimen or by the isoniazid, rifampicin, and ethambutol regimen. The association between the patient data on admission and the survival outcome was evaluated. Results We reviewed 367 consecutive patients (male, 60...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29321397/associations-between-socioeconomic-status-and-the-prevalence-and-treatment-of-hypercholesterolemia-in-a-general-japanese-population-nippon-data2010
#18
Naoko Fujiyoshi, Hisatomi Arima, Atsushi Satoh, Toshiyuki Ojima, Nobuo Nishi, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Atsushi Hozawa, Naoki Nakaya, Akira Fujiyoshi, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
AIM: To investigate associations between socioeconomic status (SES) and the prevalence and treatment status of hypercholesterolemia in a general Japanese population. METHODS: In 2010, we established a cohort study of 2417 adults (age 20-91 yr) from 300 randomly selected areas across Japan who participated in the National Health and Nutrition Survey of Japan. We cross-sectionally examined an association between SES and (1) prevalence of hypercholesterolemia in 2417 participants (999 men and 1418 women) and (2) not receiving medication for hypercholesterolemia in 654 participants (215 men and 439 women)...
January 11, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29318767/determination-of-synephrine-in-feeds-by-a-novel-quechers-solid-phase-extraction-method-combined-with-uhplc-ms-ms
#19
Yue Song, Tingting Chai, Shengting Lou, Yuechen Zhao, Xining Zhang, Shuming Yang, Yongzhong Qian, Jing Qiu
To detect and quantify synephrine in feed, an effective analytical method based on quick, easy, cheap, effective, rugged and safe solid-phase extraction coupled to ultra high performance liquid chromatography with tandem mass spectrometry was developed with isotopic internal standards. Pretreatment was performed using quick, easy, cheap, effective, rugged and safe solid-phase extraction with primary secondary amine (PSA) and C18 sorbent (C18) as sorbents in combination with Oasis MCX column clean-up to extract and purify feed samples...
January 10, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29317224/determining-reliability-of-a-dual-task-functional-mobility-protocol-for-individuals-with-lower-extremity-amputations
#20
Courtney Frengopoulos, Michael Wc Payne, Jeffrey Holmes, Ricardo Viana, Susan W Hunter
OBJECTIVES: To determine the relative and absolute reliability of a dual-task functional mobility assessment. DESIGN: Cross-sectional study. SETTING: Academic Rehabilitation Hospital. PARTICIPANTS: Sixty individuals with lower extremity amputation (LEA) attending an outpatient amputee clinic (age= 58.21±12.59; 80.0% male). Subjects were stratified into three groups: 1) transtibial amputations of vascular etiology (TTA-vas), transtibial amputations of non-vascular etiology (TTA-nonvas); transfemoral or bilateral amputees (TFA/bilat) of any etiology...
January 6, 2018: Archives of Physical Medicine and Rehabilitation
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