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https://www.readbyqxmd.com/read/28550170/right-atrial-pressure-and-venous-return-during-cardiopulmonary-bypass
#1
Per Werner Moller, Berhard Winkler, Samuel Hurni, Paul Philipp Heinisch, Andreas Martin Bloch, Soren Sondergaard, Stephan M Matthias Jakob, Jukka Takala, David Christian Berger
The relevance of right atrial pressure (RAP) as the back-pressure for venous return (QVR) and mean systemic filling pressure (MSFP) as up-stream pressure is controversial during dynamic changes of circulation. To examine the immediate response of QVR (sum of caval vein flows) to changes in RAP and pump function we used a closed chest, central cannulation, heart bypass porcine preparation (n=10) with veno-arterial extracorporeal membrane oxygenation (ECMO). MSFP was determined by clamping ECMO tubing with open or closed arterio-venous shunt at Euvolemia, Volume Expansion (9...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28549431/insecticide-treated-nets-provide-protection-against-malaria-to-children-in-an-area-of-insecticide-resistance-in-southern-benin
#2
John Bradley, Aurore Ogouyèmi-Hounto, Sylvie Cornélie, Jacob Fassinou, Yolande Sissinto Savi de Tove, Adicath Adéola Adéothy, Filémon T Tokponnon, Patrick Makoutode, Alioun Adechoubou, Thibaut Legba, Telesphore Houansou, Dorothée Kinde-Gazard, Martin C Akogbeto, Achille Massougbodji, Tessa Bellamy Knox, Martin Donnelly, Immo Kleinschmidt
BACKGROUND: Malaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa. METHODS: In 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children. RESULTS: Children who used LLINs had lower levels of malaria infection [odds ratio = 0...
May 26, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28548964/the-value-of-phosphohistone-h3-as-a-proliferation-marker-for-evaluating-invasive-breast-cancers-a-comparative-study-with-ki67
#3
Ji-Ye Kim, Hyang Sook Jeong, Taek Chung, Moonsik Kim, Ji Hee Lee, Woo Hee Jung, Ja Seung Koo
BACKGROUND: Established measurements of proliferation in breast cancer are Ki67 and mitotic-activity-index (MAI), with problems in reproducibility and prognostic accuracy. Phosphohistone H3 (PHH3), a relatively novel IHC marker is specific for mitosis with good reproducibility. We hypothesized that PHH3 would be more reproducible and better represent proliferation than Ki67. RESULTS: PHH3 identified easily-missed mitosis by MAI, as demonstrated by upgrading M grade at diagnosis (n = 29/218, evenly distributed)...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548961/identification-and-validation-of-a-prognostic-9-genes-expression-signature-for-gastric-cancer
#4
Zhiqiang Wang, Gongxing Chen, Qilong Wang, Wei Lu, Meidong Xu
Gastric cancer (GC) is a common malignant tumor with high incidence and mortality. Reasonable assessment of prognosis is essential to improve the outcomes of patients. In this study, we constructed and validated a prognostic gene model to evaluate the risks of GC patients. To identify the differentially expressed genes between GC patients and controls, we extracted Gene expression profiles of GC patients (N=432) from Gene Expression Omnibus database and then stable signature genes by using Robust likelihood-based modeling with 1000 iterations...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28545731/enzyme-linked-immunoassay-based-on-imprinted-microspheres-for-the-detection-of-sulfamethazine-residue
#5
Dapeng Peng, Zhaozhou Li, Yulian Wang, Zhenli Liu, Feng Sheng, Zonghui Yuan
This study attempts to develop an enzyme-linked immunoassay (ELISA) using a molecularly imprinted polymer (MIP) as an artificial recognition element. The MIP microspheres were prepared using precipitation polymerization with SM2 as the template molecule, methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. After the microspheres were coated in microtiter plate wells, the molecular imprinting ELISA (MI-ELISA) method was established based on the direct competition between free SM2 and horseradish peroxidase (HRP)-labelled SM2 in heterogeneous mode...
May 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28545354/solid-lipid-nanoparticles-approach-for-lymphatic-targeting-through-intraduodenal-delivery-of-quetiapine-fumarate
#6
Mohd Yasir, Praveen Kumar Gaur, Dinesh Puri, Preeti Shekar, S Sadish Kumar
BACKGROUND: Lymphatic route is one of the prominent route for improving the poor bioavailability of the drugs which undergoes extensive hepatic first pass metabolism. Nanocarriers (solid lipid nanoparticles) offers a new drug delivery system that could hold great promise for attaining the bioavailability enhancement along with controlled and site specific drug delivery. OBJECTIVE: The aim of the present research work was to prepare and optimized the Quetiapine fumarate (an antipsychotic drug) loaded solid lipid nanoparticles for lymphatic targeting through intraduodenal administration Method: Thirteen quetiapine fumarate loaded solid lipid nanoparticle formulations were developed using different lipids by Microemulsion technique and optimized by box behnken design...
May 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28544060/predictive-factors-upon-discontinuation-of-renal-replacement-therapy-for-long-term-chronic-dialysis-and-death-in-acute-kidney-injury-patients
#7
Tingting Yang, Si Sun, Liping Lin, Mei Han, Qiang Liu, Xiaoxi Zeng, Yuliang Zhao, Yupei Li, Baihai Su, Songmin Huang, Lichuan Yang
The specific timing for discontinuing renal replacement therapy (RRT) in acute kidney injury (AKI) patients is debatable. The predictive abilities of variables at the time of discontinuation of RRT for the long-term prognoses of patients have not been explored. This study aimed to explore the prognostic factors upon discontinuation of RRT for long-term chronic dialysis and death of patients with acute RRT-requiring AKI, thus improving decision making regarding the discontinuation of RRT and the follow-up of patients thereafter...
May 23, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28540415/incidence-of-osteosynthesis-of-members-in-france
#8
Patrice Papin, Eric Berthonnaud
PURPOSE: Little data is available on the number of osteosynthesis of limbs in a country. Incidence of osteosynthesis is an essential element for the formation and organization of care. Based on the data from the work of the Hospital Information Technology Agency ( http://www.atih.sante.fr/ ) and available in open access, we wanted to know the incidence of the number of osteosynthesis performed in France and their evolution over ten years between 2006 and 2015. METHODS: The data analyzed are derived from the website of the technical agency of information on the hospitalization (ATIH)...
May 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28539748/rapid-development-and-validation-of-improved-reversed-phase-high-performance-liquid-chromatography-method-for-the-quantification-of-mangiferin-a-polyphenol-xanthone-glycoside-in-mangifera-indica
#9
P Naveen, H B Lingaraju, K Shyam Prasad
Mangiferin, a polyphenolic xanthone glycoside from Mangifera indica, is used as traditional medicine for the treatment of numerous diseases. The present study was aimed to develop and validate a reversed-phase high-performance liquid chromatography (RP-HPLC) method for the quantification of mangiferin from the bark extract of M. indica. RP-HPLC analysis was performed by isocratic elution with a low-pressure gradient using 0.1% formic acid: acetonitrile (87:13) as a mobile phase with a flow rate of 1.5 ml/min...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28538472/efficacy-of-intratympanic-gentamicin-in-m%C3%A3-ni%C3%A3-re-s-disease-with-and-without-migraine
#10
Yuan F Liu, Elizabeth Renk, Steven D Rauch, Helen X Xu
OBJECTIVE: To compare the efficacy of intratympanic gentamicin injection (ITG) on vertigo control, drop attacks, and functional level in Ménière's disease patients with and without a history of migraine. PATIENTS: Ménière's disease patients (patients with migraine and age- and sex-matched control patients without migraine) treated from 2002 to 2012 who failed medical management and received ITG, with a minimum 2-year follow up. INTERVENTION: ITG...
May 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28536711/a-target-triggered-proximity-combination-based-fluorescence-sensing-strategy-for-adenosine-detection
#11
Xiaowen Xu, Haiping Wei, Wei Jiang
Adenosine is a potent physiological and pharmacological regulator, and its abnormal level is closely related to disease development. The sensitive and specific detection of adenosine is crucial for health evaluation and disease diagnosis. In this work, a target triggered proximity combination-based fluorescence sensing strategy is developed for the sensitive and specific detection of adenosine. A difunctional probe showing target recognition and signal amplification is designed, by integration of DNA linker-connected split aptamer fragments with a fragment-elongated polymerase/nicking template...
May 24, 2017: Analyst
https://www.readbyqxmd.com/read/28535632/-short-term-effects-of-fine-particulate-matter-exposure-on-pulmonary-function-in-healthy-young-adults-a-time-series-study
#12
Q Yu, J P Liao, Y Hu, X Y Li, C Zhang, X L Li, C L Que, G F Wang
Objective: To explore the short-term effects of fine particulate matter (PM2.5) exposure on pulmonary function of healthy young adults in Beijing. Methods: In this time series study, twenty-four healthy young adults who living around Guanyuan area were investigated in Beijing. The follow-up study was lasted for 12 days in total from Nov. 28, 2016 to Dec. 9, 2016, and pulmonary spirometry and inpulse oscillometry parameters were measured daily. Air pollution data (including PM2.5, etc.) and meteorological data (temperature, humidity, etc...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28534360/association-of-microrna-933-variant-with-the-susceptibility-to-gastric-cancer
#13
Yitong Zhang, Yanyun Ma, Weihong Xu, Wenshuai Li, Pei Min, Jigang Qiu, Min Li, Feng Tang, Mingqing Zhang, Dongqin Yang, Jun Zhang
PURPOSE: Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRs) have been shown to be associated with susceptibility to several types of human cancer. However, the association of miR-933 rs79402775 with gastric cancer (GC) has not been explored. METHODS: The association between rs79402775 in miR- 933 and the risk of GC was explored in Chinese population based on MassARRAY technology. A total 374 GC patients and 999 cancer-free controls were enrolled in this study...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28532098/mechanical-behavior-of-yttria-stabilized-tetragonal-zirconia-polycrystalline-ceramic-after-different-zirconia-surface-treatments
#14
Joao Luiz Pozzobon, Gabriel Kalil Rocha Pereira, Vinicius Felipe Wandscher, Lucio Strazzabosco Dorneles, Luiz Felipe Valandro
This study investigated the effects of different zirconia surface conditioning methods on the biaxial flexure strength, surface characteristics and fractographic analysis of a Y-TZP ceramic. Disc-shaped specimens were manufactured according to ISO 6872-2008 for biaxial flexure strength testing, and then randomly assigned into seven groups (n=30). Control (CTRL): without treatment; Tribochemical silica coating (TBS): specimens were sandblasted with silica-coated aluminum oxide particles (CoJet-Sand) for 10s; Silica nanofilm (SNF): specimens were silica coated with a 5nm SiO2 nanofilm; and four protocols of low-fusing porcelain glaze (GLZ): etching with 10% hydrofluoric acid gel (HF) for 1min (GLZ1), 5min (GLZ5), 10min (GLZ10) and 15min (GLZ15)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529529/disclosure-of-traditional-and-complementary-medicine-use-and-its-associated-factors-to-medical-doctor-in-primary-care-clinics-in-kuching-division-sarawak-malaysia
#15
Anak Kelak Johny, Whye Lian Cheah, Safii Razitasham
The decision by the patients to disclose traditional and complementary medicine (TCM) use to their doctor is an important area to be explored. This study aimed to determine the disclosure of TCM use and its associated factors to medical doctor among primary care clinic attendees in Kuching Division, Sarawak. It was a cross-sectional study using questionnaire, interviewer administered questionnaire. A total of 1130 patients were screened with 80.2% reporting using TCM. Logistic regression analysis revealed that being female (AOR = 3...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28529150/preventive-effect-of-phosphodiesterase-inhibitor-pentoxifylline-against-medication-related-osteonecrosis-of-the-jaw-an-animal-study
#16
Gül Merve Yalcin-Ulker, Alev Cumbul, Gonca Duygu-Capar, Ünal Uslu, Kemal Sencift
PURPOSE: The aim of this experimental study was to investigate the prophylactic effect of pentoxifylline (PTX) on medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: Female Sprague-Dawley rats (n = 33) received zoledronic acid (ZA) for 8 weeks to create an osteonecrosis model. The left mandibular second molars were extracted and the recovery period lasted 8 weeks before sacrifice. PTX was intraperitoneally administered to prevent MRONJ...
April 26, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28527516/a-feasible-economical-and-accurate-analytical-method-for-simultaneous-determination-of-six-alkaloid-markers-in-aconiti-lateralis-radix-praeparata-from-different-manufacturing-sources-and-processing-ways
#17
Yi-Bei Zhang, Juan DA, Jing-Xian Zhang, Shang-Rong Li, Xin Chen, Hua-Li Long, Qiu-Rong Wang, Lu-Ying Cai, Shuai Yao, Jin-Jun Hou, Wan-Ying Wu, De-An Guo
Aconiti Lateralis Radix Praeparata (Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines (MDAs) and diester-diterpenoidaconitines (DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate HPLC method for simultaneous determination of six alkaloid markers using the Single Standard for Determination of Multi-Components (SSDMC) method was developed and fully validated...
April 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28526277/gene-expression-patterns-in-distinct-endoscopic-findings-for-eosinophilic-gastritis-in-children
#18
Masamichi Sato, Tetsuo Shoda, Hirotaka Shimizu, Kanami Orihara, Kyoko Futamura, Akio Matsuda, Yoshiyuki Yamada, Rie Irie, Takako Yoshioka, Toshiaki Shimizu, Yukihiro Ohya, Ichiro Nomura, Kenji Matsumoto, Katsuhiro Arai
BACKGROUND: Eosinophilic gastritis (EG) is clinicopathologically characterized by both marked gastric eosinophilia and clinical symptoms. The endoscopic findings in EG vary among patients, leading to clinical confusion. However, little is known about the relationship between precise endoscopic findings and the pathophysiological process responsible for EG. OBJECTIVE: We aimed to elucidate whether the gross endoscopic findings of EG can be classified into distinct gene expression profiles...
May 16, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28523410/genomic-portrait-of-population-of-jharkhand-india-drawn-with-15-autosomal-strs-and-17-y-strs
#19
Jahangir Imam, Romana Reyaz, Rama Shankar Singh, Arun Kumar Bapuly, Pankaj Shrivastava
We analysed 15 autosomal STRs in 200 unrelated individuals (102 males and 98 females) and 17 Y-STRs in 102 unrelated males living in Jharkhand, India, to establish parameters of forensic interest. The examined autosomal STRs revealed high combined power of exclusion (CPE) and combined power of discrimination (CPD) as equal to 0.9999 and greater than 0.99999, respectively. The combined probability of match (CPm) and combined paternity index (CPI) for all 15 autosomal STR loci were found to be 5.15 × 10(-18) and 6...
May 18, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28522338/year-round-influenza-immunisation-during-pregnancy-in-nepal-a-phase-4-randomised-placebo-controlled-trial
#20
Mark C Steinhoff, Joanne Katz, Janet A Englund, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Laveta Stewart, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, Monica McNeal, Adriana M Reedy, James M Tielsch
BACKGROUND: Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year. METHODS: In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal...
May 15, 2017: Lancet Infectious Diseases
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