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Ig a nephropathy

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https://www.readbyqxmd.com/read/27815919/clinical-and-histological-risk-factors-for-progression-of-iga-nephropathy-an-update-in-children-young-and-adult-patients
#1
REVIEW
Rosanna Coppo
The identification of risk factors conditioning the progression of immunoglobulin (Ig)A nephropathy (IgAN) is needed due to the variability of the outcome of this renal disease, which ranges from remission or indolent course to progressive slow loss of renal function or rapidly evolving chronic renal failure. Based on the supposed individual risk of progression, the therapy is modulated from renin-angiotensin inhibitors to corticosteroids, alone or associated with other powerful but potentially harmful immunosuppressors...
November 4, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27811984/presence-of-streptococcus-mutans-strains-harbouring-the-cnm-gene-correlates-with-dental-caries-status-and-iga-nephropathy-conditions
#2
Taro Misaki, Shuhei Naka, Rina Hatakeyama, Akiko Fukunaga, Ryota Nomura, Taisuke Isozaki, Kazuhiko Nakano
Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of several systemic diseases. In this study, we analysed S. mutans strains isolated from the oral cavity of immunoglobulin (Ig)A nephropathy (IgAN) patients to determine potential relationships between cnm and caries status as well as IgAN conditions. Saliva specimens were collected from 109 IgAN patients and the cnm status of isolated S...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27788802/recurrent-iga-nephropathy-after-kidney-transplantation
#3
S Nijim, V Vujjini, S Alasfar, X Luo, B Orandi, C Delp, N M Desai, R A Montgomery, B E Lonze, N Alachkar
BACKGROUND: Immunoglobulin (Ig)A nephropathy is the most common primary glomerulonephritis worldwide, with a high recurrence rate after kidney transplantation. The aim of this study was to assess allograft survival, impact of recurrence on allograft function, and risk factors for post-transplant IgA recurrence. METHODS: We identified 104 patients with IgA nephropathy who underwent kidney transplantation at our center between 1993 and 2014. Fourteen patients underwent more than one allograft...
October 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27526707/paraprotein-related-kidney-disease-kidney-injury-from-paraproteins-what-determines-the-site-of-injury
#4
Mona Doshi, Amit Lahoti, Farhad R Danesh, Vecihi Batuman, Paul W Sanders
Disorders of plasma and B cells leading to paraproteinemias are associated with a variety of renal diseases. Understanding the mechanisms of injury and associated nephropathies provides a framework that aids clinicians in prompt diagnosis and appropriate adjunctive treatment of these disorders. Glomerular diseases that may be associated with paraproteinemias include amyloid deposition, monoclonal Ig deposition disease, proliferative GN with monoclonal Ig deposits, C3 glomerulopathy caused by alterations in the complement pathway, immunotactoid glomerulopathy, fibrillary GN, and cryoglobulinemia...
August 15, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27519936/cryoglobulinemia-in-a-patient-with-chronic-lymphocytic-leukemia-a-case-report-and-review-of-literature-of-renal-involvement-in-cll
#5
REVIEW
Swaty Arora, Daniel Levitan, Narottam Regmi, Gurinder Sidhu, Raavi Gupta, Anthony D Nicastri, Subodh J Saggi, Albert Braverman
The incidence of glomerulonephritis, as a manifestation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), has always been considered low. Though renal infiltration is usually detected at post-mortem, it does not often interfere with kidney function [1]. Though immunoglobulin (Ig) levels in most CLL patients are subnormal, small monoclonal Ig peaks are occasionally detected in serum. They were present in a number of reported CLL nephropathy patients, and not all were cryoglobulins; serum and glomerular staining were concordant for Ig type [2,3,4]...
September 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27368023/devastating-renal-outcome-caused-by-skin-infection-with-methicillin-resistant-staphylococcus-aureus-a-case-report
#6
Jun-Hua Liang, Yu-Wei Fang, An-Hung Yang, Ming Hsien Tsai
Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen that infects the skin and soft tissue. However, there are few reports of renal complications from MRSA involving immunoglobulin (Ig)A-dominated rapidly progressive glomerulonephritis (GN). Favorable renal outcomes from IgA GN are achieved by administering timely therapy. In the present study, we describe the case of a healthy young woman suffering from a cutaneous MRSA infection that initially presented with gross hematuria. Six months after eradicating the infection, severe impairment of renal function was noted because of intractable nausea and vomiting...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27163763/nephrology-update-glomerular-disease-in-children
#7
REVIEW
Beth Vogt
Although kidney disease is much less common in children than in adults, clinicians must remain alert for the renal conditions that occur in this population because prompt diagnosis and management are essential. Acute postinfectious glomerulonephritis occurs as an uncommon sequela of streptococcal and other infections. Management is focused on providing supportive measures, including management of fluid-electrolyte imbalance and hypertension, until the patient recovers. Immunoglobulin (Ig) A nephropathy is a primary glomerulonephritis related to abnormal IgA glycosylation...
May 2016: FP Essentials
https://www.readbyqxmd.com/read/27149502/epidemiology-of-glomerular-disease-in-southern-arizona-review-of-10-year-renal-biopsy-data
#8
Sangeetha Murugapandian, Iyad Mansour, Mohammad Hudeeb, Khaled Hamed, Emad Hammode, Babitha Bijin, Sepehr Daheshpour, Bijin Thajudeen, Pradeep Kadambi
Glomerulonephritis stands third in terms of the etiologies for end-stage kidney disease in the USA. The aim of this study was to look at the patterns of biopsy-proven glomerulonephritis based on data from a single center.Kidney biopsy specimens of all patients above the age of 18 years, over a 10-year period, who had diagnosis of nondiabetic glomerular disease, were selected for the study.The most common histopathological diagnosis was focal and segmental glomerulosclerosis (FSGS) (22.25%, 158/710) followed by membranous nephropathy (20...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27128404/-evidence-based-indications-for-tonsillectomy
#9
J P Windfuhr
BACKGROUND: One of the most significant clinical trials, demonstrating the efficacy of tonsillectomy (TE) for recurrent throat infection in severely affected children, was published in 1984. This systematic review was undertaken to compile various indications for TE as suggested in the literature after 1984 and to stratify the papers according to the current concept of Evidence-based Medicine. MATERIAL AND METHODS: A systematic Medline research was performed using the key word "tonsillectomy" in combination with different filters such as "systematic reviews", "meta-analysis", "English", "German" and "from 1984/01/01 to 2015/05/31"...
April 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27073891/regulation-of-iga-class-switch-recombination-in-immunoglobulin-a-nephropathy-retinoic-acid-signaling-and-batf
#10
Liyu He, Xiaofei Peng, Yinyin Chen, Guoyong Liu, Zhiwen Liu, Jiefu Zhu, Yexin Liu, Hong Liu, Yumei Liang, Fuyou Liu, Lin Sun, Youming Peng
BACKGROUND: Immunoglobulin (Ig) A nephropathy (IgAN) is the xFB01;nding of immune deposits predominantly containing polymeric IgA in the glomerular mesangium on renal biopsy. Increasing evidence suggested that retinoic acid (RA) signaling selectively induces IgA isotype switching and basic leucine zipper transcription factor, ATF-like (BATF) controls the global regulators of class switch recombination (CSR) in lymphocytes. Great effort has been paid to identify whether impaired immune regulation along the 'mucosa-bone marrow (BM) axis' play an important role in the pathogenesis of IgAN...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27055155/abatacept-treatment-does-not-preserve-renal-function-in-the-streptozocin-induced-model-of-diabetic-nephropathy
#11
Jenny Norlin, Lisbeth Nielsen Fink, Peter Helding Kvist, Elisabeth Douglas Galsgaard, Ken Coppieters
Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treatment of rheumatoid arthritis, could ameliorate DN. This study was designed to assess whether B7-1 signalling constitutes a promising therapeutic pathway for DN...
2016: PloS One
https://www.readbyqxmd.com/read/26971743/proliferative-glomerulonephritis-with-monoclonal-immunoglobulin-g-deposits-complicated-by-immunoglobulin-a-nephropathy-in-the-renal-allograft
#12
Anri Sawada, Kunio Kawanishi, Shigeru Horita, Junki Koike, Kazuho Honda, Ayami Ochi, Mizuki Komoda, Yoichiro Tanaka, Kohei Unagami, Masayoshi Okumi, Tomokazu Shimizu, Hideki Ishida, Kazunari Tanabe, Yoji Nagashima, Kosaku Nitta
Immunoglobulin (Ig) A nephropathy (IgAN) is a known autoimmune disease due to abnormal glycosylation of IgA1, and occasionally, IgG co-deposition occurs. The prognosis of IgG co-deposition with IgAN is adverse, as shown in the previous studies. However, in the clinical setting, monoclonality of IgG co-deposition with IgAN has not been observed. We describe a case of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) combined with IgAN in a renal allograft. A-21-year-old man developed end-stage renal failure with unknown aetiology and underwent living-donor kidney transplantation from his mother 2 years after being diagnosed...
July 2016: Nephrology
https://www.readbyqxmd.com/read/26895476/complement-gene-variants-determine-the-risk-of-immunoglobulin-associated-mpgn-and-c3-glomerulopathy-and-predict-long-term-renal-outcome
#13
Paraskevas Iatropoulos, Marina Noris, Caterina Mele, Rossella Piras, Elisabetta Valoti, Elena Bresin, Manuela Curreri, Elena Mondo, Anna Zito, Sara Gamba, Serena Bettoni, Luisa Murer, Veronique Fremeaux-Bacchi, Marina Vivarelli, Francesco Emma, Erica Daina, Giuseppe Remuzzi
BACKGROUND: Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) and C3 glomerulopathy (C3G). In this study we aimed: (1) to evaluate the complement genetic and biochemical profile in patients with Ig-MPGN/C3G; (2) to investigate whether genetic variants and different patterns of complement activation (i.e., fluid versus solid phase) correlate with disease manifestations and outcomes...
March 2016: Molecular Immunology
https://www.readbyqxmd.com/read/26877494/p-186-iga-nephropathy-clinical-and-hispathological-findings
#14
M Najjar, H Jebali, R Kheder, L Raïs, L Ben Fatma, W Smaoui, M Krid, F Ben Moussa, S Beji, K Zouaghi
OBJECTIFS: La néphropathie à IgA (NIgA) est une des glomérulonéphrites les plus communes caractérisée par le dépôt d'IgA dans le mésangium glomérulaire. Elle progresse vers l'insuffisance rénale (IR) terminale dans 10 à 30 % des cas après 20 ans d'évolution. MéTHODES: Il s'agit d'une étude rétrospective incluant 41 patients présentant un NIgA colligés sur une période de sept ans (2007-2015). Les données cliniques et para cliniques ont été recueillies à partir des observations médicales...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877366/p-067-feature-of-secondary-hypertension
#15
S Derbal, B Ben Kaab, M T Jomni, S Bellakhel, A Mestiri, H Smida, M H Dougui
OBJECTIFS: L'hypertension artérielle secondaire, ne représente que 10 % de l'ensemble de l'HTA tout venant. Les causes d'HTA secondaire sont multiples, regroupant des pathologies essentiellement endocriniennes, rénales et vasculaires. Le but de notre travail est de décrire le profil des sujets explorés pour une HTA secondaire, les étiologies et l'évolution sous traitement. MéTHODES: Nous rapportons le résultat d'une étude rétrospective sur les patients explorés pour une suspicion d'HTA secondaire que nous avons colligé au Service de Médecine Interne de l'Hôpital FSI de Tunis...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26842624/igm-nephropathy-is-it-closer-to-minimal-change-disease-or-to-focal-segmental-glomerulosclerosis
#16
REVIEW
R Brugnano, R Del Sordo, C Covarelli, E Gnappi, S Pasquali
Immunoglobulin (Ig)M nephropathy (IgMN), known since 1978, is a very controversial clinicopathological entity characterized by IgM diffuse deposits in the mesangium at immunofluorescence whereas light microscop identifies minimal glomerular lesion, hypercellularity and expansion of the mesangium or sclerotic focal, segmental lesion. Clinically, it is a nephrotic syndrome, especially in pediatric patients, or asymptomatic proteinuria and/or isolated hematuria. These characteristics narrowly define IgMN between minimal change disease and focal segmental glomerulosclerosis, so it is not often recognized as a separate pathology...
August 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/26838071/curcumin-attenuates-high-glucose-induced-podocyte-apoptosis-by-regulating-functional-connections-between-caveolin-1-phosphorylation-and-ros
#17
Li-Na Sun, Xiang-Chun Liu, Xiang-Jun Chen, Guang-Ju Guan, Gang Liu
AIM: Caveolin-1 (cav-1) is a major multifunctional scaffolding protein of caveolae. Cav-1 is primarily expressed in mesangial cells, renal proximal tubule cells and podocytes in kidneys. Recent evidence shows that the functional connections between cav-1 and ROS play a key role in many diseases. In this study we investigated whether regulating the functional connections between cav-1 and ROS in kidneys contributed to the beneficial effects of curcumin in treating diabetic nephropathy in vitro and in vivo...
May 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/26596464/canine-iga-nephropathy-a-case-report
#18
Akira Yabuki, Takako Shimokawa Miyama, Moeko Kohyama, Osamu Yamato
Immunoglobulin (Ig) A nephropathy is a rare form of canine glomerular disease. This report describes a case of canine IgA nephropathy showing characteristics typical of human IgA nephropathy. An 8-year-old, spayed female Miniature Dachshund showed persistent severe proteinuria without azotemia. She was receiving long-term glucocorticoid therapy due to chronic gastritis and an intra-abdominal suture granuloma. A renal biopsy demonstrated mesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition and electron-dense deposits in the paramesangium...
March 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26567243/mayo-clinic-renal-pathology-society-consensus-report-on-pathologic-classification-diagnosis-and-reporting-of-gn
#19
Sanjeev Sethi, Mark Haas, Glen S Markowitz, Vivette D D'Agati, Helmut G Rennke, J Charles Jennette, Ingeborg M Bajema, Charles E Alpers, Anthony Chang, Lynn D Cornell, Fernando G Cosio, Agnes B Fogo, Richard J Glassock, Sundaram Hariharan, Neeraja Kambham, Donna J Lager, Nelson Leung, Michael Mengel, Karl A Nath, Ian S Roberts, Brad H Rovin, Surya V Seshan, Richard J H Smith, Patrick D Walker, Christopher G Winearls, Gerald B Appel, Mariam P Alexander, Daniel C Cattran, Carmen Avila Casado, H Terence Cook, An S De Vriese, Jai Radhakrishnan, Lorraine C Racusen, Pierre Ronco, Fernando C Fervenza
Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim of standardizing the kidney biopsy report of GN. On the basis of etiology/pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy. The pathogenesis-based classification forms the basis of the kidney biopsy report...
May 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26537358/long-term-outcome-of-iga-nephropathy-with-minimal-change-disease-a-comparison-between-patients-with-and-without-minimal-change-disease
#20
Xiao-Wei Li, Shao-Shan Liang, Wei-Bo Le, Shui-Qin Cheng, Cai-Hong Zeng, Jin-Quan Wang, Zhi-Hong Liu
BACKGROUND: The clinicopathological characteristics, treatment response and long-term outcome of immunoglobulin (Ig)A nephropathy with minimal change disease (MCD-IgAN) are not well defined. METHODS: Patients with biopsy-proven MCD-IgAN from the Jinling Hospital IgA nephropathy Registry were systematically reviewed and compared with those with IgA nephropathy without minimal change disease (Non-MCD-IgAN). RESULTS: We compared data of 247 MCD-IgAN patients and 1,121 Non-MCD-IgAN patients...
August 2016: Journal of Nephrology
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