Yasuhiro Kamii, Koji Hayashizaki, Toshio Kanno, Akio Chiba, Taku Ikegami, Mitsuru Saito, Yukihiro Akeda, Toshiaki Ohteki, Masato Kubo, Kiyotsugu Yoshida, Kazuyoshi Kawakami, Kazunori Oishi, Jun Araya, Kazuyoshi Kuwano, Mitchell Kronenberg, Yusuke Endo, Yuki Kinjo
Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that express an invariant T cell receptor α chain and contribute to bridging innate and acquired immunity with rapid production of large amounts of cytokines after stimulation. Among effecter subsets of iNKT cells, follicular helper NKT (NKTFH ) cells are specialized to help B cells. However, the mechanisms of NKTFH cell differentiation remain to be elucidated. In this report, we studied the mechanism of NKTFH cell differentiation induced by pneumococcal surface protein A and α-galactosylceramide (P/A) vaccination...
February 27, 2024: Proceedings of the National Academy of Sciences of the United States of America