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Alessandro Jose Nunes da Silva, Ildeberto Muniz de Almeida, Rodolfo Andrade de Gouveia Vilela, Renata Wey Berti Mendes, Sandra Lorena Beltran Hurtado
The Brazilian electricity sector has recorded high work-related mortality rates that have been associated with outsourcing, used to cut costs. In order to decrease the power outage time for consumers, the industry adopted the automatic circuit recloser as the technical solution. The device has hazardous implications for maintenance workers. The aim of this study was to analyze the origins and consequences of work accidents in power systems with automatic circuit recloser, using the Accident Analysis and Prevention (AAP) model...
May 10, 2018: Cadernos de Saúde Pública
Jóhanna Vilhjálmsdóttir, Robert B Gennis, Peter Brzezinski
Cytochrome c oxidase catalyzes reduction of O2 to H2 O at a catalytic site that is composed of a copper ion and heme group. The reaction is linked to translocation of four protons across the membrane for each O2 reduced to water. The free energy associated with electron transfer to the catalytic site is unequal for the four electron-transfer events. Most notably, the free energy associated with reduction of the catalytic site in the oxidized cytochrome c oxidase (state O) is not sufficient for proton pumping across the energized membrane...
May 14, 2018: Scientific Reports
Simone Cappelletti, Daria Piacentino, Vittorio Fineschi, Paola Frati, Luigi Cipolloni, Mariarosaria Aromatario
Caffeine is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet markets. Mechanisms of action are dose-dependent. Serious toxicities such as seizure and cardiac arrhythmias, seen with caffeine plasma concentrations of 15 mg/L or higher, have caused poisoning or, rarely, death; otherwise concentrations of 3⁻6 mg/kg are considered safe. Caffeine concentrations of 80⁻100 mg/L are considered lethal...
May 14, 2018: Nutrients
Shraddha Shukla, Kashyap Kumar Dubey
Coenzyme Q10 (CoQ) or ubiquinone is found in the biological system which is synthesized by the conjugation of benzoquinone ring with isoprenoid chain of variable length. Coenzyme Q10 supplementation energizes the body and increases body energy production in the form of ATP and helps to treat various human diseases such as cardiomyopathy, muscular dystrophy, periodontal disease, etc. Reports of these potential therapeutic advantages of CoQ10 have resulted in its high market demand, which focus the researchers to work on this molecule and develop better bioprocess methods for commercial level production...
May 2018: 3 Biotech
Jesper Torbøl Pedersen, Tamara Kanashova, Gunnar Dittmar, Michael Palmgren
The yeast plasma membrane H+ -ATPase Pma1p is a P-type ATPase that energizes the yeast plasma membrane. Pma1p exists in two activation states: an autoinhibited basal state and an activated state. Here we show that functional and stable Pma1p can be purified in native form and reconstituted in artificial liposomes without altering its activation state. Acetylated tubulin has previously been reported to maintain Pma1p in the basal state but, as this protein was absent from the purified preparations, it cannot be an essential component of the autoinhibitory mechanism...
May 2018: FEBS Open Bio
Arun B Gurung, Atanu Bhattacharjee
Non-synonymous single nucleotide polymorphisms (nsSNPs) are genetic variations at single base resulting in an amino acid change which have been associated with various complex human diseases. The human Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) gene harbours a rare Q281R polymorphism which was previously reported to cause loss of enzymatic function. Lp-PLA2 is an important enzyme which catalyzes the hydrolysis of polar phospholipids releasing pro-atherogenic and pro-inflammatory mediators involved in the pathogenesis of atherosclerosis...
May 8, 2018: Journal of Cellular Biochemistry
Carolin Hagelskamp, David Schleifer, Chloe Rinehart, Rebecca Silliman
Participatory budgeting (PB)-a democratic process where ordinary residents decide directly how to spend part of a public budget-has gained impressive momentum in US municipalities, spreading from one pilot project in Chicago's 49th ward in 2009 to 50 active PB processes across 14 cities in 2016-2017. Over 93,600 US residents voted in a PB process in 2015-2016, deciding over a total of about $49.5 million and funding 264 projects intended to improve their communities. The vast majority of US PB processes take place in large urban centers (e...
May 7, 2018: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Philip C Michael, Jiho Lee, John Voccio, Juan Bascuñán, Seungyong Hahn, Yukikazu Iwasa
We present design and test results for a thermally-activated persistent-current switch (PCS) applied to a double pancake (DP) coil (151 mm ID, 172 mm OD), wound, using the no-insulation (NI) technique, from a 120-m long, 76-μm thick, 6-mm wide REBCO tape. For the experiments reported in this paper, the NI DP assembly was immersed in a volume of solid nitrogen (SN2), cooled to a base temperature of 10 K by conduction to a two-stage cryocooler, and energized at up to 630 A. The DP assembly operated in quasi-persistent mode, with the conductor tails soldered together to form a close-out joint with resistance below 6 nΩ...
April 2018: IEEE Transactions on Applied Superconductivity: a Publication of the IEEE Superconductivity Committee
Waqas Waheed, Anas Alazzam, Bobby Mathew, Nicolas Christoforou, Eiyad Abu-Nada
This short communication introduces a continuous-flow, dielectrophoresis-based lateral fluid flow fractionation microdevice for detection/isolation of circulating tumor cells in the presence of other haematological cells. The device utilizes two sets of planar interdigitated transducer electrodes micropatterned on top of a glass wafer using standard microfabrication techniques. A microchannel with a single inlet and two outlets, realized in polydimethylsiloxane, is bonded on the glass substrate. The two sets of electrodes slightly protrude into the microchannel...
April 30, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Alejandro de Athayde Moncorvo Collado, Paula B Salazar, Carlos Minahk
The interaction of enterodiol and the well-described polyphenol epigallocatechin gallate (EGCG) with hepatic membranes has been matter of interest in the last few years. On one hand, EGCG is only able to bind to the phospholipid polar head groups, as it has been already described in synthetic lipid bilayers and erythrocyte membranes but cannot get inserted into the hydrophobic core or be transported into the lumen of membrane vesicles. On the other, enterodiol has no interaction with non-energized membranes either, but it is able to interact and even be transported upon addition of ATP...
May 4, 2018: Journal of Membrane Biology
Indu Raj, Miran Mozetic, Jayachandran V Prabhu, Jiya Jose, Sabu Thomas, Nandakumar Kalarikkal
Antimicrobial, antibiofilm adherent, fracture resistant nano Zinc Oxide (ZnO NP) formulations based on poly methyl methacrylate (PMMA) matrix were developed by ex situ compression moulding technique in a facile manner. These formulations demonstrated potent, long-term biofilm-resisting effects against Candida Albicans (9000 CFU to 1000CFU) and Streptococcal Mutans. Proposed mechanism of biofilm resistance was the release of metallic ions/metal oxide by 'particle-corrosion'. MTT and cellular proliferation assays confirmed both qualitatively and quantitatively equal human skin fibroblast cell line proliferations (approximately 75%) on both PMMA/ZnO formulation and on neat PMMA...
May 4, 2018: Nanotechnology
Koji Yonekura, Saori Maki-Yonekura, Rei Matsuoka, Yoshiki Yamashita, Hirofumi Shimizu, Maiko Tanaka, Fumie Iwabuki
No abstract text is available yet for this article.
May 4, 2018: ELife
Ugonna Ohiri, C Wyatt Shields, Koohee Han, Talmage Tyler, Orlin D Velev, Nan Jokerst
Locally energized particles form the basis for emerging classes of active matter. The design of active particles has led to their controlled locomotion and assembly. The next generation of particles should demonstrate robust control over their active assembly, disassembly, and reconfiguration. Here we introduce a class of semiconductor microparticles that can be comprehensively designed (in size, shape, electric polarizability, and patterned coatings) using standard microfabrication tools. These custom silicon particles draw energy from external electric fields to actively propel, while interacting hydrodynamically, and sequentially assemble and disassemble on demand...
May 3, 2018: Nature Communications
Sankha Shuvra Das, Shantimoy Kar, Tarique Anwar, Partha Saha, Suman Chakraborty
We exploit the combinatorial advantage of electrokinetics and tortuosity of a cellulose-based paper network on laboratory grade filter paper for the development of a simple, inexpensive, yet extremely robust (shows constant performance for 12 days) 'paper-and-pencil'-based device for energy harvesting applications. We successfully achieve harvesting of a maximum output power of ∼640 pW in a single channel, while the same is significantly improved (by ∼100 times) with the use of a multichannel microfluidic array (maximum of up to 20 channels)...
May 3, 2018: Lab on a Chip
Shahnawaz Rafiq, Máté J Bezdek, Marius Koch, Paul J Chirik, Gregory D Scholes
Among the many metal-dinitrogen complexes synthesized, the end-on bridging (M-NN-M) coordination mode is notoriously unreactive for nitrogen fixation. This is principally due to the large activation energy for ground-state nitrogen-element bond formation and motivates exploration of the photoexcited reactivity of this coordination mode. To provide the foundation for this concept, the photophysics of a dinitrogen-bridged molybdenum complex was explored by ultrafast electronic spectroscopies. The complex absorbs light from the UV to near-IR and the transitions are predominantly of metal-to-ligand charge transfer (MLCT) character...
May 2, 2018: Journal of the American Chemical Society
Jessica Ashurst, Irene van Woerden, Genevieve Dunton, Michael Todd, Punam Ohri-Vachaspati, Pamela Swan, Meg Bruening
BACKGROUND: Studies have examined the associations between emotions and overeating but have only rarely considered associations between emotions and specific food choices. The purpose of this secondary data analysis was to use mobile ecological momentary assessments (mEMAs) to examine associations between emotions and food choices among first-year college students living in residence halls. METHODS: Using an intensive repeated-measures design, mEMAs were used to assess concurrent emotions and food choices in a racially/ethnically diverse sample of first-year college students (n = 663)...
May 2, 2018: BMC Public Health
P Dean, K M Sendra, T A Williams, A K Watson, P Major, S Nakjang, E Kozhevnikova, A V Goldberg, E R S Kunji, R P Hirt, T M Embley
The acquisition of genes by horizontal transfer can impart entirely new biological functions and provide an important route to major evolutionary innovation. Here we have used ancient gene reconstruction and functional assays to investigate the impact of a single horizontally transferred nucleotide transporter into the common ancestor of the Microsporidia, a major radiation of intracellular parasites of animals and humans. We show that this transporter provided early microsporidians with the ability to steal host ATP and to become energy parasites...
April 27, 2018: Nature Communications
Mary H Mundt
This article presents reflections of a recently retired dean of nursing on lessons learned and recommendations on the decanal role. The experience reflects a twenty-year period in dean positions at research universities in three states. The lessons learned relate to 1) forming a strategic vision, 2) using vision and strategic priorities to inform decisions and actions, and 3) communicating the vision and strategic framework. The conclusion looks to the future development of a cadre of energized and supported future leaders who will assume deanships in nursing...
March 2018: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
Huicheng Wang, Ergang Wang, Baorong Zhang
In this paper, scientific theory was used to prove that the meridian was the resonant channel of information energy of life, and experiment and demonstration was performed to reveal meridians to explore the significance of revealing meridian. Based on the theory of physics, biochemistry, molecular biology and information theory, the essence of meridian was demonstrated in theory. According to TCM meridian theory, acupuncture was applied at selected acupoints; the infrared thermograms of stomach meridian of foot yangming , large intestine meridian of hand yangming , small intestine meridian of hand taiyang , pericardium meridian of hand jueyin , heart meridian of hand shaoyin , triple energizer meridian of hand shaoyang , liver meridian of foot jueyin , bladder meridian of foot taiyang were recorded before and after acupuncture...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Denisa Baci, Antonino Bruno, Barbara Bassani, Matilde Tramacere, Lorenzo Mortara, Adriana Albini, Douglas M Noonan
Carnitines play an important role in the energy exchange in cells, involved in the transport of fatty acids across the inner mitochondrial membrane. L-Acetylcarnitine (ALCAR) is an acetic acid ester of carnitine that has higher bioavailability than carnitine and is considered a fat-burning energizer supplement. We previously found that in serum samples from prostate cancer (PCa) patients, 3 carnitine family members were significantly decreased, suggesting a potential protective role of carnitine against PCa...
April 17, 2018: Cancer Letters
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