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Nao Yoshida, Shintaro Yamazaki, Masahiko Sugitani, Tadatoshi Takayama
Energy devices can cause significant thermal damage to surrounding tissues causing unanticipated organ trauma. To evaluate the safety and feasibility of a novel electric device (DD1) for soft tissue dissection. Three series of measurements were performed in a pig model. First, macro- and microscopic tissue damage was compared between the DD1 and an electric scalpel (ES). Second, the time course of tissue temperature was measured for the DD1 and three other energy devices (ES, Harmonic and LigaSure). Third, the time required for mobilization of a peripheral artery of the intestine was compared between the DD1 and manual, non-energized forceps...
2018: Bioscience Trends
Simone Aparecida Penimpedo Calamita, Daniela Aparecida Biasotto-Gonzalez, Nívea Cristina De Melo, Marco Antônio Fumagalli, César Ferreira Amorim, Cid André Fidelis de Paula Gomes, Fabiano Politti
OBJECTIVE: The objective of this study was to assess changes in upper trapezius myoelectric activity and pain in patients with nonspecific neck pain after a single session of acupuncture (ACP). METHODS: A blinded randomized clinical trial was conducted. Fifteen patients with nonspecific neck pain and 15 healthy participants were enrolled in a randomized, single-blinded, crossover study. Each participant was subjected to a single session of ACP and sham acupuncture (SACP)...
March 2018: Journal of Manipulative and Physiological Therapeutics
Bo Hou, Eyleen S Heidrich, Denise Mehner-Breitfeld, Thomas Brüser
The twin-arginine translocation (Tat) system that comprises the TatA, TatB, and TatC components transports folded proteins across energized membranes of prokaryotes and plant plastids. It is not known, however, how the transport of this protein cargo is achieved. Favored models suggest that the TatA component supports transport by weakening the membrane upon full translocon assembly. Using Escherichia coli as model organism, we now demonstrate in vivo that the N-terminus of TatA can indeed destabilize the membrane, resulting in a lowered membrane energization in growing cells...
March 13, 2018: Journal of Biological Chemistry
Hideki Kandori, Keiichi Inoue, Satoshi P Tsunoda
Ion pumps perform active transport of ions by using energy. The active transport mechanism can be illustrated by the Panama Canal model, which considers two gates and a gain in energy. The Panama Canal model is consistent with the alternating access model that is used to describe active transport, in which the substrate ion is bound, energized, and released. It was generally accepted that energization occurs only for an ion-bound protein but not for an ion-unbound protein. Light-driven proton and chloride pumps, two of the best studied pumps, are represented by the Panama Canal model...
March 7, 2018: Chemical Reviews
Jae-Hun Jeoung, Holger Dobbek
Chemically demanding reductive conversions in biology, such as the reduction of dinitrogen to ammonia or the Birch-type reduction of aromatic compounds, depend on Fe/S-cluster-containing ATPases. These reductions are typically catalyzed by two-component systems, in which an Fe/S-cluster-containing ATPase energizes an electron to reduce a metal site on the acceptor protein that drives the reductive reaction. Here, we show a two-component system featuring a double-cubane [Fe8 S9 ]-cluster [{Fe4 S4 (SCys)3 }2 ( μ 2 -S)]...
March 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
John Vissing, Corrado Angelini
No abstract text is available yet for this article.
March 2, 2018: Neurology
Vera L Rasera Zotelli, Cássia M Grillo, Maria L Bressiani Gil, Ronaldo S Wada, Jorge E Sato, Maria da Luz R de Sousa
Temporomandibular dysfunction (TMD) is a set of changes that affects the muscles of mastication, temporomandibular joint, teeth, and associated periodontal and orofacial structures. According to Traditional Chinese Medicine, the imbalance of energy (Qi) circulating in the acupuncture meridians is always the primary etiologic cause of any physical manifestation. The aim of this study was to describe the patterns of Qi imbalance in patients with TMD by means of an objective measurement. The clinical study was conducted at the Piracicaba Dental School (FOP/Unicamp), in Piracicaba-SP, Brazil...
February 2018: Journal of Acupuncture and Meridian Studies
Pengna Zhao, Yanping Wang, Feifei Gu, Chaozheng Li, Yulong Wei, Guangjun Wang, Weibo Zhang
OBJECTIVE: To observe the impacts of the intervention with electric thermal bian stone and air suction cup on blood perfusion (BP) at meridian points and explore the approach of accurate measurement and regulation of meridian qi and blood balance in "precise acupuncture". METHODS: The laser Doppler line scanner (LDLS) was used to measure BP at bilateral yua n-primary points at the pericardium meridian, the triple energizer meridian, the gallbladder meridian and the liver meridian (small cycle of jueyin to shaoyang meridians) at 31 healthy receptors...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Róli R Simões, Scheila I Kraus, Igor S Coelho, Daniela Dal-Secco, Diogo A Siebert, Gustavo A Micke, Michele D Alberton, Adair R S Santos
ETHNOPHARMACOLOGICAL RELEVANCE: Eugenia brasiliensis Lam. (Myrtaceae) is a Brazilian tree distributed throughout Atlantic rain forest, since Bahia until Santa Catarina state, and is popularly known as "grumixaba, grumixameira, cumbixaba, ibaporoiti, and cereja-brasileira". The bark and leaves of Eugenia brasiliensis are used in folk medicine as adstringent, diuretic, energizing, anti-rheumatic and anti-inflammatory. This study aimed at investigating the chemical composition, antinociceptive and anti-inflammatory effect of the hydroalcoholic extract of Eugenia brasiliensis (HEEb)...
February 17, 2018: Journal of Ethnopharmacology
Susan M Squier
Parasites!, a 2010 comic sponsored by the Wellcome Trust Centre for Molecular Parasitology, demonstrates that a graphic narrative can play a role in energizing public debate. Part of the genre known as graphic medicine-comics about illness, treatment, disability, and caregiving-Parasites! is intended to educate readers of all ages about illnesses less known in the developed world. Two visual strategies in particular enable the comic to offer an alternative and aesthetic response to questions about developing drugs to treat tropical diseases for profit...
February 1, 2018: AMA Journal of Ethics
Dániel Szöllősi, Gergely Szakács, Peter Chiba, Thomas Stockner
P-glycoprotein, also known as multidrug resistance protein 1 or ABCB1, can export a wide range of chemically unrelated compounds, including chemotherapeutic drugs. ABCB1 consists of two transmembrane domains that form the substrate binding and translocation domain, and of two cytoplasmic nucleotide binding domains (NBDs) that energize substrate transport by ATP binding and hydrolysis. ATP binding triggers dimerization of the NBDs, which switches the transporter from an inward facing to an outward facing transmembrane domain conformation...
January 23, 2018: Biophysical Journal
Ziye Wu, Peng Cui, Guozhen Zhang, Yi Luo, Jun Jiang
Achieving high charge recombination probability has been the major challenge for the practical utilization of molecule-based solar harvesting. Molecular switches were introduced to stabilize the charge separation state in donor-acceptor systems, but it is difficult to seamlessly incorporate the ON/OFF switching actions into the opto-electronic conversion cycle. Here we present a self-adaptive system where the donor and acceptor are bridged by a switchable moiety that enables a complete charge separation repeatedly...
February 3, 2018: Journal of Physical Chemistry Letters
Hope M Tiesman, Melody Gwilliam, Srinivas Konda, Jeff Rojek, Suzanne Marsh
INTRODUCTION: Limited studies exist that describe nonfatal work-related injuries to law enforcement officers. The aim of this study is to provide national estimates and trends of nonfatal injuries to law enforcement officers from 2003 through 2014. METHODS: Nonfatal injuries were obtained from the National Electronic Injury Surveillance System-Occupational Supplement. Data were obtained for injuries treated in U.S. emergency departments from 2003 to 2014. Nonfatal injury rates were calculated using denominators from the Current Population Survey...
January 26, 2018: American Journal of Preventive Medicine
Juan J Pérez, Ana González-Suárez, Andre d'Avila, Enrique Berjano
PURPOSE: Although bipolar radiofrequency (RF) ablation (RFA) is broadly used to eliminate ventricular tachycardias in the interventricular septum wall, it can fail to create transmural lesions in thick ventricular walls. To solve this problem, we explored whether an RF-energized guidewire inserted into the ventricular wall would enhance bipolar RFA in the creation of transmural lesions through the ventricular wall. METHODS: We built three-dimensional computational models including two irrigated electrodes placed on opposing sides of the interventricular septum and a metal guidewire inserted into the septum...
February 2, 2018: International Journal of Hyperthermia
I H Cairns, V V Lobzin, A Donea, S J Tingay, P I McCauley, D Oberoi, R T Duffin, M J Reiner, N Hurley-Walker, N A Kudryavtseva, D B Melrose, J C Harding, G Bernardi, J D Bowman, R J Cappallo, B E Corey, A Deshpande, D Emrich, R Goeke, B J Hazelton, M Johnston-Hollitt, D L Kaplan, J C Kasper, E Kratzenberg, C J Lonsdale, M J Lynch, S R McWhirter, D A Mitchell, M F Morales, E Morgan, S M Ord, T Prabu, A Roshi, N Udaya Shankar, K S Srivani, R Subrahmanyan, R B Wayth, M Waterson, R L Webster, A R Whitney, A Williams, C L Williams
Type III solar radio bursts are the Sun's most intense and frequent nonthermal radio emissions. They involve two critical problems in astrophysics, plasma physics, and space physics: how collective processes produce nonthermal radiation and how magnetic reconnection occurs and changes magnetic energy into kinetic energy. Here magnetic reconnection events are identified definitively in Solar Dynamics Observatory UV-EUV data, with strong upward and downward pairs of jets, current sheets, and cusp-like geometries on top of time-varying magnetic loops, and strong outflows along pairs of open magnetic field lines...
January 26, 2018: Scientific Reports
Xin Wang, Marcin Habrych, Bogdan Miedzinski, Julian Wosik
This paper presents and discusses usefulness and possibility of control of the singular points location of a driving magnetic field under as structure considerations as well as selection of energizing magnet systems for miniature electromagnetic switches. The sample results of theoretical analysis and experimental testing concern selected reed switches with normally open contacts as well as a developed miniature switch with a metallic ball contact. It must be noted that the switch with the contact performed by means of the metallic tiny ball can be effectively used both as a change-over switch as well as a detector of the energizing magnetic field distribution under designing and assembling of any electromagnetic contact device preferably with an increased degree of integration and miniaturization...
January 26, 2018: Sensors
Karl-Josef Dietz, G Heinrich Krause, Katharina Siebke, Anja Krieger-Liszkay
The dynamic and efficient coordination of primary photosynthetic reactions with leaf energization and metabolism under a wide range of environmental conditions is a fundamental property of plants involving processes at all functional levels. The present historical perspective covers 60 years of research aiming to understand the underlying mechanisms, linking major breakthroughs to current progress. It centers on the contributions of Ulrich Heber who had pioneered novel concepts, fundamental methods, and mechanistic understanding of photosynthesis...
January 24, 2018: Photosynthesis Research
Heinz Isliker, Loukas Vlahos, Dana Constantinescu
We analyze statistically the energization of particles in a large scale environment of strong turbulence that is fragmented into a large number of distributed current filaments. The turbulent environment is generated through strongly perturbed, 3D, resistive magnetohydrodynamics simulations, and it emerges naturally from the nonlinear evolution, without a specific reconnection geometry being set up. Based on test-particle simulations, we estimate the transport coefficients in energy space for use in the classical Fokker-Planck (FP) equation, and we show that the latter fails to reproduce the simulation results...
July 28, 2017: Physical Review Letters
Richard A Tell, Christopher A Tell
BACKGROUND: Limits for exposure to radiofrequency (RF) contact currents are specified in the two dominant RF safety standards and guidelines developed by the Institute of Electrical and Electronics Engineers (IEEE) and the International Commission on Non-Ionizing Radiation Protection (ICNIRP). These limits are intended to prevent RF burns when contacting RF energized objects caused by high local tissue current densities. We explain what contact currents are and review some history of the relevant limits with an emphasis on so-called "touch" contacts, i...
January 15, 2018: Biomedical Engineering Online
Denis G Knyazev, Roland Kuttner, Mirjam Zimmermann, Ekaterina Sobakinskaya, Peter Pohl
This review focusses on the energetics of protein translocation via the Sec translocation machinery. First we complement structural data about SecYEG's conformational rearrangements by insight obtained from functional assays. These include measurements of SecYEG permeability that allow assessment of channel gating by ligand binding and membrane voltage. Second we will discuss the power stroke and Brownian ratcheting models of substrate translocation and the role that the two models assign to the putative driving forces: (i) ATP (SecA) and GTP (ribosome) hydrolysis, (ii) interaction with accessory proteins, (iii) membrane partitioning and folding, (iv) proton motive force (PMF), and (v) entropic contributions...
January 12, 2018: Journal of Membrane Biology
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