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https://www.readbyqxmd.com/read/28098416/motuporamine-derivatives-as-antimicrobial-agents-and-antibiotic-enhancers-against-resistant-gram-negative-bacteria
#1
Diane Borselli, Marine Blanchet, Jean-Michel Bolla, Aaron Muth, Kristen Skruber, Otto Phanstiel, Jean Michel Brunel
Dihydromotuporamine C and its derivatives were evaluated for their in vitro antimicrobial activities and antibiotic enhancement properties against Gram-negative bacteria and clinical isolates. The mechanism of action of one of these derivatives, MOTU-N44, was investigated against Enterobacter aerogenes by using fluorescent dyes to evaluate outer-membrane depolarization and permeabilization. Its efficiency correlated with inhibition of dye transport, thus suggesting that these molecules inhibit drug transporters by de-energization of the efflux pump rather than by direct interaction of the molecule with the pump...
January 18, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28079288/surface-enhanced-raman-spectra-promoted-by-a-finger-press-in-an-all-solid-state-flexible-energy-conversion-and-storage-film
#2
Haitao Li, Han Dai, Yihe Zhang, Wangshu Tong, Hua Gao, Qi An
Electrochemically up-regulated surface-enhanced Raman spectroscopy (E-SERS) effectively increases Raman signal intensities. However, the instrumental requirements and the conventional measurement conditions in an electrolyte cell have hampered its application in fast and on-site detection. To circumvent the inconveniences of E-SERS, we propose a self-energizing substrate that provides electrical potential by converting film deformation from a finger press into stored electrical energy. The substrate combines an energy conversion film and a SERS-active Ag nanowire layer...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28076263/-a-paradox-persists-when-the-paradigm-is-wrong-pisacano-scholars-reflections-from-the-inaugural-starfield-summit
#3
Noemi Doohan, Anastasia J Coutinho, Jennifer Lochner, Diana Wohler, Jennifer DeVoe
The inaugural Starfield Summit was hosted in April 2016 by the Robert Graham Center for Policy Studies in Family Medicine and Primary Care with additional partners and sponsors, including the Pisacano Leadership Foundation (PLF). The Summit addressed critical topics in primary care and health care delivery, including payment, measurement, and team-based care. Invited participants included an interdisciplinary group of pediatricians, family physicians, internists, behaviorists, trainees, researchers, and advocates...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28013504/macromolecule-biosynthesis-assay-and-fluorescence-spectroscopy-methods-to-explore-antimicrobial-peptide-mode-s-of-action
#4
Bimal Jana, Kristin Renee Baker, Luca Guardabassi
Antimicrobial peptides (AMPs) are viable alternatives to the currently available antimicrobials, and numerous studies have investigated their possible use as therapeutic agents for specific clinical applications. AMPs are a diverse class of antimicrobials that often act upon the bacterial cell membrane but may exhibit additional modes of action. Identification of the multiple modes of action requires a comprehensive study at subinhibitory concentrations and careful data analysis since additional modes of action can be eclipsed by AMP action on the cell membrane...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28011846/two-distinct-membrane-potential-dependent-steps-drive-mitochondrial-matrix-protein-translocation
#5
Alexander Benjamin Schendzielorz, Christian Schulz, Oleksandr Lytovchenko, Anne Clancy, Bernard Guiard, Raffaele Ieva, Martin van der Laan, Peter Rehling
Two driving forces energize precursor translocation across the inner mitochondrial membrane. Although the membrane potential (Δψ) is considered to drive translocation of positively charged presequences through the TIM23 complex (presequence translocase), the activity of the Hsp70-powered import motor is crucial for the translocation of the mature protein portion into the matrix. In this study, we show that mitochondrial matrix proteins display surprisingly different dependencies on the Δψ. However, a precursor's hypersensitivity to a reduction of the Δψ is not linked to the respective presequence, but rather to the mature portion of the polypeptide chain...
January 2, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28007968/nitrite-protects-mitochondrial-structure-and-function-under-hypoxia
#6
Kapuganti Jagadis Gupta, Chun Pong Lee, R George Ratcliffe
Oxygen deprivation leads to changes in mitochondrial morphology and impaired flow of reducing equivalents through the electron transport chain. The extent of these changes depends on the duration and severity of the treatment as well as on the species and cell type. Nitrate is known to ameliorate these effects in some instances, but it is possible that it is nitrite, rather than nitrate, that is the key to the mechanism. To test this, mitochondria were isolated from 21-day-old pea (Pisum sativum) roots and incubated for 90 min under normoxia or hypoxia in the presence or absence of 0...
October 25, 2016: Plant & Cell Physiology
https://www.readbyqxmd.com/read/27991824/symbolic-meanings-of-sex-in-relationships-developing-the-meanings-of-sexual-behavior-inventory
#7
Amanda M Shaw, Ronald D Rogge
Consistent with symbolic interactionism and motivation research, the study explored the meanings of sexual behavior in romantic relationships in a sample of 3,003 online respondents. Starting with a pool of 104 respondent-generated items, Exploratory and Confirmatory Factor analyses in separate sample halves revealed a stable set of 9 dimensions within that item pool that formed 2 higher-order factors representing positive (to share pleasure, to bond, to de-stress, to energize the relationship, to learn more about each other) and negative (to manage conflict, as an incentive, to express anger, and to control partner) meanings of sexual behavior within relationships...
December 19, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27986867/sucrose-transporter-localization-and-function-in-phloem-loading-and-unloading
#8
Ricky J Milne, Jai M Perroux, Anne L Rae, Anke Reinders, John M Ward, Christina E Offler, John William Patrick, Christopher P L Grof
How sucrose transporters (SUTs) regulate phloem unloading in monocot stems is poorly understood and particularly so for species storing high sucrose concentrations. To this end Sorghum bicolor SUTs, SbSUT1 and SbSUT5 were characterized, by determining their transport properties heterologously expressed in yeast or Xenopus oocytes, and their in planta cellular- and sub-cellular localization. The plasma membrane-localized SbSUT1 and SbSUT5 exhibited a strong selectivity for sucrose and high sucrose affinities in Xenopus oocytes at pH 5...
December 16, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27970230/tct-839-acute-safety-and-technical-performance-evaluation-of-a-novel-cto-crossing-device-based-on-a-shock-wave-energized-guidewire
#9
Louis-Philippe Riel, Manuel Charlebois-Ménard, Steven Dion, Stéphane Rinfret, Jean-Franà Ois Tanguay, Marie-Élaine Clavet, Marie-Jeanne Bertrand, Pascale Geoffroy, Simon Berube, Marc-Antoine Despatis, Marianne Brodmann, Éric Thérèse, Andrew Benko, Louis-Georges Guy, Guy LeClerc, Madeleine Chagnon, Martin Brouillette
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27967187/multispecies-plasma-expansion-into-vacuum-the-role-of-secondary-ions-and-suprathermal-electrons
#10
I S Elkamash, I Kourakis
The self-similar expansion of multispecies ion plasma is investigated by a two-ion fluid model with adiabatic equation of state for each ionic species. Our aim is to elucidate the effect of secondary ions on a plasma expansion front, in combination with energetic (suprathermal) electrons in the background, modeled by a kappa-type distribution function. The plasma density, velocity, and electric-field profile is investigated. It is shown that energetic electrons have a significant effect on the expansion front dynamics, essentially energizing the front, thus enhancing the ion acceleration mechanism...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27966965/the-symmetric-exchange-reaction-oh-h2o-%C3%A2-h2o-oh-convergent-quantum-mechanical-predictions
#11
Aifang Gao, Guoliang Li, Bin Peng, Yaoming Xie, Henry F Schaefer
The symmetric hydrogen exchange reaction OH + H2O → H2O + OH has been studied using the "gold standard" CCSD(T) method with the correlation-consistent basis sets up to aug-cc-pV5Z. The CCSDT and CCSDT(Q) methods were used for the final energic predictions. Two entrance complexes and two transition states on the H3O2 potential surface were located. The vibrational frequencies and the zero-point vibrational energies of these stationary points for the reaction are reported. The entrance complex H2O···HO is predicted to lie 3...
December 29, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27966081/vectorization-of-agrochemicals-amino-acid-carriers-are-more-efficient-than-sugar-carriers-to-translocate-phenylpyrrole-conjugates-in-the-ricinus-system
#12
Hanxiang Wu, Sophie Marhadour, Zhi-Wei Lei, Wen Yang, Cécile Marivingt-Mounir, Jean-Louis Bonnemain, Jean-François Chollet
Producing quality food in sufficient quantity while using less agrochemical inputs will be one of the great challenges of the twenty-first century. One way of achieving this goal is to greatly reduce the doses of plant protection compounds by improving the targeting of pests to eradicate. Therefore, we developed a vectorization strategy to confer phloem mobility to fenpiclonil, a contact fungicide from the phenylpyrrole family used as a model molecule. It consists in coupling the antifungal compound to an amino acid or a sugar, so that the resulting conjugates are handled by active nutrient transport systems...
December 13, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27936248/light-mediated-generation-of-silver-nanoparticles-by-spinach-thylakoids-chloroplasts
#13
Nisha Shabnam, P Sharmila, Hyunook Kim, P Pardha-Saradhi
The unique potential of chloroplasts/thylakoids to harness light energy to transport electrons from H2O to various entities was exploited for reduction of Ag+ to generate nanoparticles (NPs). Spinach thylakoids/chloroplasts turned AgNO3 solutions brown in light, but not in dark. Besides showing Ag-NPs specific surface plasmon resonance band, these brown solutions showed presence of 5-30 nm crystalline NPs composed of Ag. Powder X-ray diffraction (PXRD) analysis revealed that Ag-NPs were biphasic composed of face-centered cubic Ag0 and cubic Ag2O...
2016: PloS One
https://www.readbyqxmd.com/read/27935000/sheet-like-and-truncated-dodecahedron-like-agi-structures-via-a-surfactant-assisted-protocol-and-their-morphology-dependent-photocatalytic-performance
#14
Dan Xiao, Guangwei Geng, Penglei Chen, Tiesheng Li, Minghua Liu
Silver halide-based structures have been attracting great interest as efficient visible-light-driven photocatalysts towards the photodegradation of organic pollutants, and those studies focusing on their morphology-dependent catalytic performances have received particular attention. While great advancements in this regard have been witnessed in the past few years with respect to AgCl- and AgBr-based photocatalysts, relevant explorations concerning AgI-based species are relatively rare, even though the excellent durability of AgI-based structures renders them attractive candidates for potential photocatalytic uses...
December 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27930324/dopamine-release-from-the-locus-coeruleus-to-the-dorsal-hippocampus-promotes-spatial-learning-and-memory
#15
Kimberly A Kempadoo, Eugene V Mosharov, Se Joon Choi, David Sulzer, Eric R Kandel
Dopamine neurotransmission in the dorsal hippocampus is critical for a range of functions from spatial learning and synaptic plasticity to the deficits underlying psychiatric disorders such as attention-deficit hyperactivity disorder. The ventral tegmental area (VTA) is the presumed source of dopamine in the dorsal hippocampus. However, there is a surprising scarcity of VTA dopamine axons in the dorsal hippocampus despite the dense network of dopamine receptors. We have explored this apparent paradox using optogenetic, biochemical, and behavioral approaches and found that dopaminergic axons and subsequent dopamine release in the dorsal hippocampus originate from neurons of the locus coeruleus (LC)...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27922018/non-thermal-hydrogen-atoms-in-the-terrestrial-upper-thermosphere
#16
Jianqi Qin, Lara Waldrop
Model predictions of the distribution and dynamical transport of hydrogen atoms in the terrestrial atmosphere have long-standing discrepancies with ultraviolet remote sensing measurements, indicating likely deficiencies in conventional theories regarding this crucial atmospheric constituent. Here we report the existence of non-thermal hydrogen atoms that are much hotter than the ambient oxygen atoms in the upper thermosphere. Analysis of satellite measurements indicates that the upper thermospheric hydrogen temperature, more precisely the mean kinetic energy of the atomic hydrogen population, increases significantly with declining solar activity, contrary to contemporary understanding of thermospheric behaviour...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27911552/relativistic-electrons-produced-by-foreshock-disturbances-observed-upstream-of-earth-s-bow-shock
#17
L B Wilson, D G Sibeck, D L Turner, A Osmane, D Caprioli, V Angelopoulos
Charged particles can be reflected and accelerated by strong (i.e., high Mach number) astrophysical collisionless shock waves, streaming away to form a foreshock region in communication with the shock. Foreshocks are primarily populated by suprathermal ions that can generate foreshock disturbances-large-scale (i.e., tens to thousands of thermal ion Larmor radii), transient (∼5-10  per day) structures. They have recently been found to accelerate ions to energies of several keV. Although electrons in Saturn's high Mach number (M>40) bow shock can be accelerated to relativistic energies (nearly 1000 keV), it has hitherto been thought impossible to accelerate electrons beyond a few tens of keV at Earth's low Mach number (1≤M<20) bow shock...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27902924/simple-mechanisms-of-early-life-simulation-model-on-the-origin-of-semi-cells
#18
Adrian Klein, Martin Bock, Wolfgang Alt
The development of first cellular structures played an important role in the early evolution of life. Early evolution of life probably took place on a molecular level in a reactive environment. The iron-sulfur theory postulates the formation of cell-like structures on catalytic surfaces. Experiments show that H2S together with FeS and other metallic centers drive auto-catalytic surface reactions, in which organic molecules such as pyruvic and amino acids occur. It is questionable which mechanisms are needed to form cell-like structures under these conditions...
November 27, 2016: Bio Systems
https://www.readbyqxmd.com/read/27899503/postreplication-roles-of-the-brucella-virb-type-iv-secretion-system-uncovered-via-conditional-expression-of-the-virb11-atpase
#19
Erin P Smith, Cheryl N Miller, Robert Child, Jennifer A Cundiff, Jean Celli
: Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host phagocytes, where it undergoes an intracellular cycle within a dedicated membrane-bound vacuole, the Brucella-containing vacuole (BCV). Initially of endosomal origin (eBCV), BCVs are remodeled into replication-permissive organelles (rBCV) derived from the host endoplasmic reticulum, a process that requires modulation of host secretory functions via delivery of effector proteins by the Brucella VirB type IV secretion system (T4SS)...
November 29, 2016: MBio
https://www.readbyqxmd.com/read/27867796/highly-relativistic-radiation-belt-electron-acceleration-transport-and-loss-large-solar-storm-events-of-march-and-june-2015
#20
D N Baker, A N Jaynes, S G Kanekal, J C Foster, P J Erickson, J F Fennell, J B Blake, H Zhao, X Li, S R Elkington, M G Henderson, G D Reeves, H E Spence, C A Kletzing, J R Wygant
Two of the largest geomagnetic storms of the last decade were witnessed in 2015. On 17 March 2015, a coronal mass ejection-driven event occurred with a Dst (storm time ring current index) value reaching -223 nT. On 22 June 2015 another strong storm (Dst reaching -204 nT) was recorded. These two storms each produced almost total loss of radiation belt high-energy (E ≳ 1 MeV) electron fluxes. Following the dropouts of radiation belt fluxes there were complex and rather remarkable recoveries of the electrons extending up to nearly 10 MeV in kinetic energy...
July 2016: Journal of Geophysical Research. Space Physics
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