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https://www.readbyqxmd.com/read/28426322/formative-research-to-design-a-promotional-campaign-to-increase-drinking-water-among-central-american-latino-youth-in-an-urban-area
#1
Nicole Barrett, Uriyoán Colón-Ramos, Allison Elkins, Ivonne Rivera, W Douglas Evans, Mark Edberg
Latinos consume more sugary drinks and less water than other demographic groups. Our objective was to understand beverage choice motivations and test promotional concepts that can encourage Central American Latino urban youth to drink more water. Two rounds of focus group discussions were conducted (n = 10 focus groups, 61 participants, 6-18 years old). Data were transcribed verbatim and analyzed using inductive and deductive coding approaches. Youth motivations for drinking water were shaped by level of thirst, weather, energy, and perceptions of health benefits...
April 20, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28409644/amphiphilic-tobramycin-lysine-conjugates-sensitize-multidrug-resistant-gram-negative-bacteria-to-rifampicin-and-minocycline
#2
Yinfeng Lyu, Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Temilolu Idowu, Ronald Domalaon, George G Zhanel, Anshan Shan, Frank M Schweizer
Chromosomally-encoded low membrane permeability and highly efficient efflux systems are major mechanisms by which Pseudomonas aeruginosa evades antibiotic actions. Our previous reports have shown that amphiphilic tobramycin-fluoroquinolone hybrids can enhance efficacy of fluoroquinolone antibiotics against multidrug-resistant (MDR) P. aeruginosa isolates. Herein, we report on a novel class of tobramycin-lysine conjugates containing an optimized amphiphilic tobramycin-C12 tether which sensitize Gram-negative bacteria to legacy antibiotics...
April 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28393831/determining-the-bacterial-cell-biology-of-planctomycetes
#3
Christian Boedeker, Margarete Schüler, Greta Reintjes, Olga Jeske, Muriel C F van Teeseling, Mareike Jogler, Patrick Rast, Daniela Borchert, Damien P Devos, Martin Kucklick, Miroslava Schaffer, Roberto Kolter, Laura van Niftrik, Susanne Engelmann, Rudolf Amann, Manfred Rohde, Harald Engelhardt, Christian Jogler
Bacteria of the phylum Planctomycetes have been previously reported to possess several features that are typical of eukaryotes, such as cytosolic compartmentalization and endocytosis-like macromolecule uptake. However, recent evidence points towards a Gram-negative cell plan for Planctomycetes, although in-depth experimental analysis has been hampered by insufficient genetic tools. Here we develop methods for expression of fluorescent proteins and for gene deletion in a model planctomycete, Planctopirus limnophila, to analyse its cell organization in detail...
April 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28389964/ion-selectivity-of-the-flagellar-motors-derived-from-the-alkaliphilic-bacillus-and-paenibacillus-species
#4
Yuka Takahashi, Masahiro Ito
Many bacteria can swim using their flagella, which are filamentous organelles that extend from the cell surface. The flagellar motor is energized by either a proton (H(+)) or sodium ion (Na(+)) as the motive force. MotAB-type stators use protons, whereas MotPS- and PomAB-type stators use Na(+) as the coupling ions. Recently, alkaliphilic Bacillus alcalophilus was shown to use potassium ions (K(+)) and rubidium ions (Rb(+)) for flagellar rotation, and the flagellar motor from Paenibacillus sp. TCA-20 uses divalent cations such as magnesium ions (Mg(2+)), calcium ions (Ca(2+)), and strontium ions (Sr(2+)) for coupling...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28389963/dynamics-in-the-dual-fuel-flagellar-motor-of-shewanella-oneidensis%C3%A2-mr-1
#5
Susanne Brenzinger, Kai M Thormann
The stator is an eminent component of the flagellar motor and determines a number of the motor's properties, such as the rotation-energizing coupling ion (H(+) or Na(+)) or the torque that can be generated. The stator consists of several units located in the cytoplasmic membrane surrounding the flagellar drive shaft. Studies on flagellar motors of several bacterial species have provided evidence that the number as well as the retention time of stators coupled to the motor is highly dynamic and depends on the environmental conditions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28367242/the-nor1-oscp1-proteins-in-cancer-from-epigenetic-silencing-to-functional-characterization-of-a-novel-tumor-suppressor
#6
REVIEW
Mei Yi, Jianbo Yang, Wenjuan Li, Xiaoling Li, Wei Xiong, James B McCarthy, Guiyuan Li, Bo Xiang
NOR1 (Oxidored-nitro domain-containing protein 1), also known as OSCP1, was first identified in nasopharyngeal carcinoma (NPC) cells in 2003. NOR1 is evolutionarily conserved among species with its expression is restricted to brain, testis and respiratory epithelial cells. NOR1 was downregulated in NPC and the downregulation associates with poor prognosis. Previous study demonstrated that hypermethylation of NOR1 promoter was observed in NPC and hematological malignancies, which has been believed to be the main epigenetic cause for NOR1 silencing in these cancers...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28356327/the-crossover-conformational-shift-of-the-gtpase-atlastin-provides-the-energy-driving-er-fusion
#7
James Winsor, David D Hackney, Tina H Lee
The homotypic fusion of endoplasmic reticulum membranes is catalyzed by the atlastin GTPase. The mechanism involves trans-dimerization between GTPase heads and a favorable crossover conformational shift, catalyzed by GTP hydrolysis, that converts the dimer from a "prefusion" to "postfusion" state. However, whether crossover formation actually energizes fusion remains unclear, as do the sequence of events surrounding it. Here, we made mutations in atlastin to selectively destabilize the crossover conformation and used fluorescence-based kinetic assays to analyze the variants...
March 29, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28322636/health-care-providers-spirit-at-work-within-a-restructured-workplace
#8
Joan I J Wagner, Denise Brooks, Ann-Marie Urban
Spirit at work (SAW) research emerged as a response to care provider determination to maintain a healthy and productive health care work environment, despite restructuring. The aim of this descriptive mixed-methods research is to present the care provider's perceptions of SAW. SAW is a holistic measure of care provider workplace outcomes, defined as the unique experience of individuals who are passionate about and energized by their work. A mixed group of licensed and unlicensed care providers in a continuing care workplace were surveyed...
December 1, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28302573/stair-walking-is-more-energizing-than-low-dose-caffeine-in-sleep-deprived-young-women
#9
Derek D Randolph, Patrick J O'Connor
INTRODUCTION: The acute energizing effect of exercise and caffeine has never been examined in a single study of adults with chronic sleep deprivation but evidence from a study of this type could help individuals choose between these two common alertness-enhancing options. AIM: The apriori primary aim of this experiment was to compare the influence of 10-min of low-to-moderate intensity stair walking to the consumption of capsules containing 50mg caffeine or flour (placebo) on feelings of energy in physically active, college female caffeine users with chronic insufficient sleep...
March 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28300620/catabolism-of-gaba-succinic-semialdehyde-or-gamma-hydroxybutyrate-through-the-gaba-shunt-impair-mitochondrial-substrate-level-phosphorylation
#10
Dora Ravasz, Gergely Kacso, Viktoria Fodor, Kata Horvath, Vera Adam-Vizi, Christos Chinopoulos
GABA is catabolized in the mitochondrial matrix through the GABA shunt, encompassing transamination to succinic semialdehyde followed by oxidation to succinate by the concerted actions of GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), respectively. Gamma-hydroxybutyrate (GHB) is a neurotransmitter and a psychoactive drug that could enter the citric acid cycle through transhydrogenation with α-ketoglutarate to succinic semialdehyde and d-hydroxyglutarate, a reaction catalyzed by hydroxyacid-oxoacid transhydrogenase (HOT)...
March 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28300410/delayed-molecular-triplet-generation-from-energized-lead-sulfide-quantum-dots
#11
Sofia Garakyaraghi, Cédric Mongin, Devin B Granger, John E Anthony, Felix N Castellano
The generation and transfer of triplet excitons across the molecular-semiconductor interface represents an important technological breakthrough featuring numerous fundamental scientific questions. This contribution demonstrates curious delayed formation of TIPS-pentacene molecular triplet excitons bound on the surface of PbS nanocrystals mediated through the initial production of a proposed charge transfer intermediate following selective excitation of the PbS quantum dots. Ultrafast UV-vis and near-IR transient absorption spectroscopy was used to track the dynamics of the initial PbS exciton quenching as well as time scale of the formation of molecular triplet excited states that persisted for 10 μs on the PbS surface, enabling subsequent energy and electron transfer reactivity...
March 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28300158/the-receptor-like-pseudokinase-mrh1-interacts-with-the-voltage-gated-potassium-channel-akt2
#12
Kamil Sklodowski, Janin Riedelsberger, Natalia Raddatz, Gonzalo Riadi, Julio Caballero, Isabelle Chérel, Waltraud Schulze, Alexander Graf, Ingo Dreyer
The potassium channel AKT2 plays important roles in phloem loading and unloading. It can operate as inward-rectifying channel that allows H(+)-ATPase-energized K(+) uptake. Moreover, through reversible post-translational modifications it can also function as an open, K(+)-selective channel, which taps a 'potassium battery', providing additional energy for transmembrane transport processes. Knowledge about proteins involved in the regulation of the operational mode of AKT2 is very limited. Here, we employed a large-scale yeast two-hybrid screen in combination with fluorescence tagging and null-allele mutant phenotype analysis and identified the plasma membrane localized receptor-like kinase MRH1/MDIS2 (AT4G18640) as interaction partner of AKT2...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264993/going-outside-the-tonb-box-identification-of-novel-fepa-tonb-interactions-in-vivo
#13
Michael G Gresock, Kathleen Postle
In Gram-negative bacteria, the cytoplasmic membrane protein TonB transmits energy derived from protonmotive force to energize transport of important nutrients through TonB-dependent transporters in the outer membrane. Each transporter consists of a beta-barrel domain and a lumen-occluding cork domain containing an essential sequence called the TonB box. To date, the only identified site of transporter-TonB interaction is between the TonB box and residues ∼158-162 of TonB. While the mechanism of ligand transport is a mystery, a current model based on site-directed spin labeling and molecular dynamics simulations is that, following ligand binding, the otherwise-sequestered TonB box extends into the periplasm for recognition by TonB, which mediates transport by pulling or twisting the cork...
March 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28257350/executive-summary-transforming-moral-distress-into-moral-resilience-in-nursing
#14
Cynda Hylton Rushton, Kathy Schoonover-Shoffner, Maureen Shawn Kennedy
To examine practices for addressing moral distress, a collaborative project was developed by the Johns Hopkins Berman Institute of Bioethics, the Johns Hopkins School of Nursing, the American Journal of Nursing, and the Journal of Christian Nursing, along with the American Association of Critical-Care Nurses and the American Nurses Association. Its purpose was to identify strategies that individuals and systems can use to mitigate the detrimental effects of moral distress and foster moral resilience. On August 11 and 12, 2016, an invitational symposium, State of the Science: Transforming Moral Distress into Moral Resilience in Nursing, was held at the Johns Hopkins School of Nursing in Baltimore, Maryland...
April 2017: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/28256846/anisotropic-electron-tail-generation-during-tearing-mode-magnetic-reconnection
#15
Ami M DuBois, Abdulgader F Almagri, Jay K Anderson, Daniel J Den Hartog, John David Lee, John S Sarff
The first experimental evidence of anisotropic electron energization during magnetic reconnection that favors a direction perpendicular to the guide magnetic field in a toroidal, magnetically confined plasma is reported in this Letter. Magnetic reconnection plays an important role in particle heating, energization, and transport in space and laboratory plasmas. In toroidal devices like the Madison Symmetric Torus, discrete magnetic reconnection events release large amounts of energy from the equilibrium magnetic field...
February 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28252098/hepatitis-c-drugs-re-energize-global-fight-over-patents
#16
Amy Maxmen
No abstract text is available yet for this article.
March 1, 2017: Nature
https://www.readbyqxmd.com/read/28249048/chloroquine-triggers-epstein-barr-virus-replication-through-phosphorylation-of-kap1-trim28-in-burkitt-lymphoma-cells
#17
Xiaofan Li, Eric M Burton, Sumita Bhaduri-McIntosh
Trials to reintroduce chloroquine into regions of Africa where P. falciparum has regained susceptibility to chloroquine are underway. However, there are long-standing concerns about whether chloroquine increases lytic-replication of Epstein-Barr virus (EBV), thereby contributing to the development of endemic Burkitt lymphoma. We report that chloroquine indeed drives EBV replication by linking the DNA repair machinery to chromatin remodeling-mediated transcriptional repression. Specifically, chloroquine utilizes ataxia telangiectasia mutated (ATM) to phosphorylate the universal transcriptional corepressor Krüppel-associated Box-associated protein 1/tripartite motif-containing protein 28 (KAP1/TRIM28) at serine 824 -a mechanism that typically facilitates repair of double-strand breaks in heterochromatin, to instead activate EBV...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28248980/tolerance-to-exercise-intensity-modulates-pleasure-when-exercising-in-music-the-upsides-of-acoustic-energy-for-high-tolerant-individuals
#18
Mauraine Carlier, Yvonne Delevoye-Turrell
Moderate physical activity can be experienced by some as pleasurable and by others as discouraging. This may be why many people lack sufficient motivation to participate in the recommended 150 minutes of moderately intense exercise per week. In the present study, we assessed how pleasure and enjoyment were modulated differently by one's tolerance to self-paced physical activity. Sixty-three healthy individuals were allocated to three independent experimental conditions: a resting condition (watching TV), a cycling in silence condition, and a cycling in music condition...
2017: PloS One
https://www.readbyqxmd.com/read/28246633/flocking-ferromagnetic-colloids
#19
Andreas Kaiser, Alexey Snezhko, Igor S Aranson
Assemblages of microscopic colloidal particles exhibit fascinating collective motion when energized by electric or magnetic fields. The behaviors range from coherent vortical motion to phase separation and dynamic self-assembly. Although colloidal systems are relatively simple, understanding their collective response, especially under out-of-equilibrium conditions, remains elusive. We report on the emergence of flocking and global rotation in the system of rolling ferromagnetic microparticles energized by a vertical alternating magnetic field...
February 2017: Science Advances
https://www.readbyqxmd.com/read/28243875/location-location-location-where-we-teach-primary-care-makes-all-the-difference
#20
Christine Cassel, Michael Wilkes
Creating a new model to train a high-quality primary care workforce is of great interest to American health care stakeholders. There is consensus that effective educational approaches need to be combined with a rewarding work environment, emphasize a good work/life balance, and a focus on achieving meaningful outcomes that center on patients and the public. Still, significant barriers limit the numbers of clinicians interested in pursuing careers in primary care, including low earning potential, heavy medical school debt, lack of respect from physician colleagues, and enormous burdens of record keeping...
April 2017: Journal of General Internal Medicine
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