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https://www.readbyqxmd.com/read/28722147/surface-isoelectric-focusing-sief-with-carrier-ampholyte-ph-gradient
#1
Zhichao Wang, Cornelius Ivory, Adrienne R Minerick
Isoelectric focusing (IEF) is a powerful tool for amphoteric protein separations because of high sensitivity, bio-compatibility, and reduced complexity compared to chromatography or mechanical separation techniques. IEF miniaturization is attractive because it enables rapid analysis, easier adaptation to point of care applications, and smaller sample demands. However, existing small-scale IEF tools have not yet been able to analyze single protein spots from array libraries, which are ubiquitous in many pharmaceutical discovery and screening protocols...
July 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28716463/combination-strategies-on-the-basis-of-immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer-where-do-we-stand
#2
REVIEW
Meng Qiao, Tao Jiang, Shengxiang Ren, Caicun Zhou
The era of immune checkpoint inhibitors, especially programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) antibodies in the treatment of advanced non-small-cell lung cancer (NSCLC) is coming. Because of the lack of the definite biomarkers to select the optimal responders, only approximately 20% of patients with advanced NSCLC would respond to single checkpoint inhibitors-based immunotherapy. Moreover, primary or acquired resistance to conventional therapies is inevitable in most cases. Thus, combinations are pushed to move forward to be an alternative strategy and surely, it would be a future direction...
June 23, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28698776/the-sleeping-brain
#3
Chiara Cirelli, Giulio Tononi
The role of sleep has long baffled scientists, but the latest research is providing new indicators about what it does for both the brain and body. While scientists believe that sleep re-energizes the body's cells, clears waste from the brain, and supports learning and memory, much still needs to be learned about the part it plays in regulating mood, appetite and libido. Source/Shutterstock.
May 2017: Cerebrum: the Dana Forum on Brain Science
https://www.readbyqxmd.com/read/28675240/a-multi-dielectric-layered-triboelectric-nanogenerator-as-energized-by-corona-discharge
#4
Jia Jia Shao, Wei Tang, Tao Jiang, Xiang Yu Chen, Liang Xu, Bao Dong Chen, Tao Zhou, Chao Ran Deng, Zhong Lin Wang
Triboelectric nanogenerators (TENGs) have been invented recently for meeting the power requirements of small electronics and potentially solving the worldwide energy crisis. Here, we developed a vertical contact-separation mode TENG based on a novel multi-dielectric-layered (MDL) structure, which was comprised of parylene C, polyimide and SiO2 films. By using the corona discharge approach, the surface charge density was enhanced to as high as 283 μC m(-2), and especially the open-circuit voltage could be increased by a factor of 55 compared with the original value...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28659511/ronald-epstein-md-bringing-mindfulness-into-the-examination-room
#5
Ronald Epstein
Advances in Mind-Body Medicine (Advances): You have come out with a book recently, titled Attending: Medicine, Mindfulness, and Humanity. What was the motive for writing this book? Dr Epstein: I knew that it was time to expand beyond writing for medical audiences and peer-reviewed journals when 2 realizations struck me. One is that important change in medicine often comes from the outside in as opposed to from the inside out. The degree to which the public is educated and energized about an issue can produce a change in medicine...
April 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28643868/the-potassium-battery-a-mobile-energy-source-for-transport-processes-in-plant-vascular-tissues
#6
REVIEW
Ingo Dreyer, Judith Lucia Gomez-Porras, Janin Riedelsberger
Contents I. II. III. IV. V. VI. VII. VIII. References SUMMARY: Plant roots absorb potassium ions from the soil and transport them in the xylem via the transpiration stream to the shoots. There, in source tissues where sufficient chemical energy (ATP) is available, K(+) is loaded into the phloem and then transported with the phloem stream to other parts of the plant; in part, transport is also back to the roots. This, at first sight, futile cycling of K(+) has been uncovered to be part of a sophisticated mechanism that (1) enables the shoot to communicate its nutrient demand to the root, (2) contributes to the K(+) nutrition of transport phloem tissues and (3) transports energy stored in the K(+) gradient between phloem cytosol and the apoplast...
June 23, 2017: New Phytologist
https://www.readbyqxmd.com/read/28596814/enhancement-of-mitochondrial-transfer-by-antioxidants-in-human-mesenchymal-stem-cells
#7
Chia-Jung Li, Po-Kong Chen, Li-Yi Sun, Cheng-Yoong Pang
Excessive reactive oxygen species is the major component of a harsh microenvironment after ischemia/reperfusion injury in human tissues. Combined treatment of N-acetyl-L-cysteine (NAC) and L-ascorbic acid 2-phosphate (AAP) promoted the growth of human mesenchymal stem cells (hMSCs) and suppressed oxidative stress-induced cell death by enhancing mitochondrial integrity and function in vitro. In this study, we aimed to determine whether NAC and AAP (termed MCA) could enhance the therapeutic potential of hMSCs...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28594520/pediatric-metacarpal-fractures
#8
Jenna Godfrey, Roger Cornwall
Metacarpal fractures account for 10% to 35% of all pediatric hand fractures. Pediatric metacarpal fractures commonly occur in patients aged 13 to 16 years, with most injuries sustained during sports activities. Pseudoepiphyses can be confused with metacarpal fractures; however, a careful physical examination can help physicians distinguish the two. Thumb metacarpal base fractures that involve the physis warrant special attention. Thumb metacarpal base fractures with lateral metaphyseal fragments and pediatric Bennett fracture variants (Salter-Harris type III and type IV fractures) are unstable and require surgical management...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28581300/reverse-ego-depletion-acts-of-self-control-can-improve-subsequent-performance-in-indian-cultural-contexts
#9
Krishna Savani, Veronika Job
The strength model of self-control has been predominantly tested with people from Western cultures. The present research asks whether the phenomenon of ego-depletion generalizes to a culture emphasizing the virtues of exerting mental self-control in everyday life. A pilot study found that whereas Americans tended to believe that exerting willpower on mental tasks is depleting, Indians tended to believe that exerting willpower is energizing. Using dual task ego-depletion paradigms, Studies 1a, 1b, and 1c found reverse ego-depletion among Indian participants, such that participants exhibited better mental self-control on a subsequent task after initially working on strenuous rather than nonstrenuous cognitive tasks...
June 5, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28580284/nnt-reverse-mode-of-operation-mediates-glucose-control-of-mitochondrial-nadph-and-glutathione-redox-state-in-mouse-pancreatic-%C3%AE-cells
#10
Laila R B Santos, Carole Muller, Arnaldo H de Souza, Hilton K Takahashi, Peter Spégel, Ian R Sweet, Heeyoung Chae, Hindrik Mulder, Jean-Christophe Jonas
OBJECTIVE: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depends on increased production of metabolic coupling factors, including NADPH. Nicotinamide nucleotide transhydrogenase (NNT) typically produces NADPH at the expense of NADH and ΔpH in energized mitochondria. Its spontaneous inactivation in C57BL/6J mice was previously shown to alter ATP production, Ca(2+) influx, and GSIS, thereby leading to glucose intolerance. Here, we tested the role of NNT in the glucose regulation of mitochondrial NADPH and glutathione redox state and reinvestigated its role in GSIS coupling events in mouse pancreatic islets...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28579421/an-interactive-ambulatory-nephrology-curriculum-for-internal%C3%A2-medicine-interns-design-implementation-and-participant%C3%A2-feedback
#11
Alexis C Gomez, Karen M Warburton, Rachel K Miller, Dan Negoianu, Jordana B Cohen
While diminishing nephrology fellow recruitment is a known issue, more work is needed to evaluate possible interventions to reverse this trend. We designed and implemented a curriculum to increase exposure to ambulatory nephrology among internal medicine interns. The curriculum focused on key aspects of outpatient nephrology practice, including supervised clinic visits, formal themed didactic content, and an online interactive forum with assigned evidence-based readings and small-group responses to relevant cases...
June 2, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28540223/asian-herbals-and-aphrodisiacs-used-for-managing-ed
#12
REVIEW
Peter H C Lim
In the East, many herbal tonics and preparations are used to assist the aging male improve his sexual drive or ability to perform penetrative sex by increasing sexual stimulation, erectile, ejaculatory, orgasmic and other responses for sexual function and satisfaction. The herbs and tonics act as or as "pick-me-ups" and energizing tonics which help the tired and fatigued male and those with sexual asthenia. The myths and realities concerning Tongkat Ali, sea horse, cobra meat and blood, animal penises and testicles amongst many other herbs and portions for oral intake or local application used by traditional "medical" practitioners and village doctors will be discussed...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28537287/reaction-mechanism-and-product-branching-ratios-of-the-ch-c3h4-reactions-a-theoretical-study
#13
Joao Marcelo Ribeiro, Alexander M Mebel
Two ground-state CH radical reactions with the C3H4 isomers allene and methylacetylene occurring along the C4H5 potential energy surface (PES) were studied to probe the reaction mechanisms and final product distributions. The calculations were performed using a CCSD(T)-F12//B2PLYPD3 PES in combination with the 1-D chemical master equation. The reaction between the CH radical and allene was found to lead to exclusive "funneling" of the energized C4H5 intermediates into linear C4H5 configurations before reaching the exit channels, regardless of the specific nature of the initial bimolecular reactive encounter...
June 7, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28531097/evolution-not-revolution-nutrition-and-obesity
#14
Elaine C Rush, Mary R Yan
The increasing prevalence of obesity over the course of life is a global health challenge because of its strong and positive association with significant health problems such as type 2 diabetes, cardiovascular disease, stroke, and some cancers. The complex causes and drivers of obesity include genetic factors, social, ecological and political influences, food production and supply, and dietary patterns. Public health messages and government food and activity guidelines have little impact; the retail food environment has many low-priced, nutrient-poor, but energy-dense products and there is a gap between what an individual knows and what they do...
May 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28515085/regulation-of-atp-production-dependences-on-calcium-concentration-and-respiratory-state
#15
Brian D Fink, Fan Bai, Liping Yu, William I Sivitz
Nanomolar free calcium enhances oxidative phosphorylation. However, the effects over a broad concentration range, at different respiratory states, or on specific energy substrates are less clear. We examined the action of varying [Ca(2+)] over respiratory states ranging 4 to 3 on skeletal muscle mitochondrial respiration, potential, ATP production, and H2O2 production using ADP recycling to clamp external [ADP]. 450 nM calcium enhanced respiration in mitochondria energized by the complex I substrates, glutamate/malate (but not succinate) at [ADP] of 4-256 µM, but more substantially at intermediate respiratory states and not all at state 4...
May 17, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28504659/structure-of-the-macab-tolc-abc-type-tripartite-multidrug-efflux-pump
#16
Anthony W P Fitzpatrick, Salomé Llabrés, Arthur Neuberger, James N Blaza, Xiao-Chen Bai, Ui Okada, Satoshi Murakami, Hendrik W van Veen, Ulrich Zachariae, Sjors H W Scheres, Ben F Luisi, Dijun Du
The MacA-MacB-TolC assembly of Escherichia coli is a transmembrane machine that spans the cell envelope and actively extrudes substrates, including macrolide antibiotics and polypeptide virulence factors. These transport processes are energized by the ATPase MacB, a member of the ATP-binding cassette (ABC) superfamily. We present an electron cryo-microscopy structure of the ABC-type tripartite assembly at near-atomic resolution. A hexamer of the periplasmic protein MacA bridges between a TolC trimer in the outer membrane and a MacB dimer in the inner membrane, generating a quaternary structure with a central channel for substrate translocation...
May 15, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28499548/mortality-risks-associated-with-emergency-admissions-during-weekends-and-public-holidays-an-analysis-of-electronic-health-records
#17
A Sarah Walker, Amy Mason, T Phuong Quan, Nicola J Fawcett, Peter Watkinson, Martin Llewelyn, Nicole Stoesser, John Finney, Jim Davies, David H Wyllie, Derrick W Crook, Tim E A Peto
BACKGROUND: Weekend hospital admission is associated with increased mortality, but the contributions of varying illness severity and admission time to this weekend effect remain unexplored. METHODS: We analysed unselected emergency admissions to four Oxford University National Health Service hospitals in the UK from Jan 1, 2006, to Dec 31, 2014. The primary outcome was death within 30 days of admission (in or out of hospital), analysed using Cox models measuring time from admission...
July 1, 2017: Lancet
https://www.readbyqxmd.com/read/28498434/a-ligand-based-and-enediyne-energized-bispecific-fusion-protein-targeting-epidermal-growth-factor-receptor-and-insulin-like-growth-factor-1-receptor-shows-potent-antitumor-efficacy-against-esophageal-cancer
#18
Hai-Ying Cao, Xiao-Fang Guo, Xiao-Fei Zhu, Sai-Sai Li, Yong-Su Zhen
Recent studies have revealed that the epidermal growth factor receptor (EGFR) and insulin-like growth factor-1 receptor (IGF-1R) are overexpressed in various types of human tumors and are attractive targets for anticancer drugs. In the present study, the expression of EGFR and IGF-1R in esophageal squamous cell carcinoma (ESCC) and adjacent normal tissues in a tissue microarray was firstly detected by immunohistochemical staining. In addition, their co-overexpression was observed in 48 out of 75 (64%) patients...
April 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28484817/pen-torch-transillumination-difficult-venepuncture-made-easy
#19
Elijah Zhengyang Cai, Kalarani Sankaran, Monica Tan, Yiong Huak Chan, Thiam Chye Lim
INTRODUCTION: Our novel technique of pen torch transillumination (PTI) uses a cheap and easily available instrument (Penlite-LP212(®), Energizer(®), Missouri, USA) to visualize superficial veins invisible to the naked eye. We evaluate the efficacy of PTI in improving venepuncture success rate (SR) for patients with poor venous access. METHODS: This prospective randomized controlled trial looked at adult patients (n = 69) aged 21-90 with difficult venous access (history of ≥3 consecutive attempts required for successful cannulation during the current admission) requiring non-emergent venepuncture...
May 8, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28471396/under-5-energize-tracking-progress-of-a-preschool-nutrition-and-physical-activity-programme-with-regional-measures-of-body-size-and-dental-health-at-age-of-four-years
#20
Elaine Rush, Vladimir Obolonkin, Leanne Young, Madeleine Kirk, Marilyn Tseng
To reduce weight gain and encourage healthy eating including reduced sugar intake, Under 5 Energize (U5E) was introduced to 121 early-childhood-centres in the Waikato region of New Zealand in July 2013. Using anonymized data collected from January 2013 to September 2016 through free physical assessments of all 4-year-olds provided by the NZ Ministry of Health, the prevalence of obesity and dental decay children measured in the Waikato region was examined. Data were divided into four periods representing pre-implementation and 3 years of gradual implementation...
May 4, 2017: Nutrients
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