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Energency

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https://www.readbyqxmd.com/read/28302573/stair-walking-is-more-energizing-than-low-dose-caffeine-in-sleep-deprived-young-women
#1
Derek D Randolph, Patrick J O'Connor
INTRODUCTION: The acute energizing effect of exercise and caffeine has never been examined in a single study of adults with chronic sleep deprivation but evidence from a study of this type could help individuals choose between these two common alertness-enhancing options. AIM: The apriori primary aim of this experiment was to compare the influence of 10-min of low-to-moderate intensity stair walking to the consumption of capsules containing 50mg caffeine or flour (placebo) on feelings of energy in physically active, college female caffeine users with chronic insufficient sleep...
March 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28300620/catabolism-of-gaba-succinic-semialdehyde-or-gamma-hydroxybutyrate-through-the-gaba-shunt-impair-mitochondrial-substrate-level-phosphorylation
#2
Dora Ravasz, Gergely Kacso, Viktoria Fodor, Kata Horvath, Vera Adam-Vizi, Christos Chinopoulos
GABA is catabolized in the mitochondrial matrix through the GABA shunt, encompassing transamination to succinic semialdehyde followed by oxidation to succinate by the concerted actions of GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), respectively. Gamma-hydroxybutyrate (GHB) is a neurotransmitter and a psychoactive drug that could enter the citric acid cycle through transhydrogenation with α-ketoglutarate to succinic semialdehyde and d-hydroxyglutarate, a reaction catalyzed by hydroxyacid-oxoacid transhydrogenase (HOT)...
March 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28300410/delayed-molecular-triplet-generation-from-energized-lead-sulfide-quantum-dots
#3
Sofia Garakyaraghi, Cedric Mongin, Devin B Granger, John E Anthony, Felix N Castellano
The generation and transfer of triplet excitons across the molecular-semiconductor interface represents an important technological breakthrough featuring numerous fundamental scientific questions. This contribution demonstrates unprecedented delayed formation of TIPS-pentacene molecular triplet excitons bound on the surface of PbS nanocrystals mediated through the initial production of a proposed charge transfer intermediate following selective excitation of the PbS quantum dots. Ultrafast UV-Vis and near-IR transient absorption spectroscopy was used to track the dynamics of the initial PbS exciton quenching as well as time scale of the formation of molecular triplet excited states that persisted for 10 μs on the PbS surface, enabling subsequent energy and electron transfer reactivity...
March 16, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28300158/the-receptor-like-pseudokinase-mrh1-interacts-with-the-voltage-gated-potassium-channel-akt2
#4
Kamil Sklodowski, Janin Riedelsberger, Natalia Raddatz, Gonzalo Riadi, Julio Caballero, Isabelle Chérel, Waltraud Schulze, Alexander Graf, Ingo Dreyer
The potassium channel AKT2 plays important roles in phloem loading and unloading. It can operate as inward-rectifying channel that allows H(+)-ATPase-energized K(+) uptake. Moreover, through reversible post-translational modifications it can also function as an open, K(+)-selective channel, which taps a 'potassium battery', providing additional energy for transmembrane transport processes. Knowledge about proteins involved in the regulation of the operational mode of AKT2 is very limited. Here, we employed a large-scale yeast two-hybrid screen in combination with fluorescence tagging and null-allele mutant phenotype analysis and identified the plasma membrane localized receptor-like kinase MRH1/MDIS2 (AT4G18640) as interaction partner of AKT2...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264993/going-outside-the-tonb-box-identification-of-novel-fepa-tonb-interactions-in-vivo
#5
Michael G Gresock, Kathleen Postle
In Gram-negative bacteria, the cytoplasmic membrane protein TonB transmits energy derived from protonmotive force to energize transport of important nutrients through TonB-dependent transporters in the outer membrane. Each transporter consists of a beta-barrel domain and a lumen-occluding cork domain containing an essential sequence called the TonB box. To date, the only identified site of transporter-TonB interaction is between the TonB box and residues ∼158-162 of TonB. While the mechanism of ligand transport is a mystery, a current model based on site-directed spin labeling and molecular dynamics simulations is that, following ligand binding, the otherwise-sequestered TonB box extends into the periplasm for recognition by TonB, which mediates transport by pulling or twisting the cork...
March 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28257350/executive-summary-transforming-moral-distress-into-moral-resilience-in-nursing
#6
Cynda Hylton Rushton, Kathy Schoonover-Shoffner, Maureen Shawn Kennedy
To examine practices for addressing moral distress, a collaborative project was developed by the Johns Hopkins Berman Institute of Bioethics, the Johns Hopkins School of Nursing, the American Journal of Nursing, and the Journal of Christian Nursing, along with the American Association of Critical-Care Nurses and the American Nurses Association. Its purpose was to identify strategies that individuals and systems can use to mitigate the detrimental effects of moral distress and foster moral resilience. On August 11 and 12, 2016, an invitational symposium, State of the Science: Transforming Moral Distress into Moral Resilience in Nursing, was held at the Johns Hopkins School of Nursing in Baltimore, Maryland...
April 2017: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/28256846/anisotropic-electron-tail-generation-during-tearing-mode-magnetic-reconnection
#7
Ami M DuBois, Abdulgader F Almagri, Jay K Anderson, Daniel J Den Hartog, John David Lee, John S Sarff
The first experimental evidence of anisotropic electron energization during magnetic reconnection that favors a direction perpendicular to the guide magnetic field in a toroidal, magnetically confined plasma is reported in this Letter. Magnetic reconnection plays an important role in particle heating, energization, and transport in space and laboratory plasmas. In toroidal devices like the Madison Symmetric Torus, discrete magnetic reconnection events release large amounts of energy from the equilibrium magnetic field...
February 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28252098/hepatitis-c-drugs-re-energize-global-fight-over-patents
#8
Amy Maxmen
No abstract text is available yet for this article.
March 1, 2017: Nature
https://www.readbyqxmd.com/read/28249048/chloroquine-triggers-epstein-barr-virus-replication-through-phosphorylation-of-kap1-trim28-in-burkitt-lymphoma-cells
#9
Xiaofan Li, Eric M Burton, Sumita Bhaduri-McIntosh
Trials to reintroduce chloroquine into regions of Africa where P. falciparum has regained susceptibility to chloroquine are underway. However, there are long-standing concerns about whether chloroquine increases lytic-replication of Epstein-Barr virus (EBV), thereby contributing to the development of endemic Burkitt lymphoma. We report that chloroquine indeed drives EBV replication by linking the DNA repair machinery to chromatin remodeling-mediated transcriptional repression. Specifically, chloroquine utilizes ataxia telangiectasia mutated (ATM) to phosphorylate the universal transcriptional corepressor Krüppel-associated Box-associated protein 1/tripartite motif-containing protein 28 (KAP1/TRIM28) at serine 824 -a mechanism that typically facilitates repair of double-strand breaks in heterochromatin, to instead activate EBV...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28248980/tolerance-to-exercise-intensity-modulates-pleasure-when-exercising-in-music-the-upsides-of-acoustic-energy-for-high-tolerant-individuals
#10
Mauraine Carlier, Yvonne Delevoye-Turrell
Moderate physical activity can be experienced by some as pleasurable and by others as discouraging. This may be why many people lack sufficient motivation to participate in the recommended 150 minutes of moderately intense exercise per week. In the present study, we assessed how pleasure and enjoyment were modulated differently by one's tolerance to self-paced physical activity. Sixty-three healthy individuals were allocated to three independent experimental conditions: a resting condition (watching TV), a cycling in silence condition, and a cycling in music condition...
2017: PloS One
https://www.readbyqxmd.com/read/28246633/flocking-ferromagnetic-colloids
#11
Andreas Kaiser, Alexey Snezhko, Igor S Aranson
Assemblages of microscopic colloidal particles exhibit fascinating collective motion when energized by electric or magnetic fields. The behaviors range from coherent vortical motion to phase separation and dynamic self-assembly. Although colloidal systems are relatively simple, understanding their collective response, especially under out-of-equilibrium conditions, remains elusive. We report on the emergence of flocking and global rotation in the system of rolling ferromagnetic microparticles energized by a vertical alternating magnetic field...
February 2017: Science Advances
https://www.readbyqxmd.com/read/28243875/location-location-location-where-we-teach-primary-care-makes-all-the-difference
#12
Christine Cassel, Michael Wilkes
Creating a new model to train a high-quality primary care workforce is of great interest to American health care stakeholders. There is consensus that effective educational approaches need to be combined with a rewarding work environment, emphasize a good work/life balance, and a focus on achieving meaningful outcomes that center on patients and the public. Still, significant barriers limit the numbers of clinicians interested in pursuing careers in primary care, including low earning potential, heavy medical school debt, lack of respect from physician colleagues, and enormous burdens of record keeping...
February 27, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28237732/discerning-the-antioxidant-mechanism-of-rapanone-a-naturally-occurring-benzoquinone-with-iron-complexing-and-radical-scavenging-activities
#13
Karen de la Vega-Hernández, Manuel Antuch, Osmany Cuesta-Rubio, Yanier Núñez-Figueredo, Gilberto L Pardo-Andreu
Oxidative stress resulting from iron and reactive oxygen species (ROS) homeostasis breakdown has been implicated in several diseases. Therefore, molecules capable of binding iron and/or scavenging ROS may be reasonable strategies for protecting cells. Rapanone is a naturally occurring hydroxyl-benzoquinone with a privileged chelating structure. In this work, we addressed the antioxidant properties of rapanone concerning its iron-chelating and scavenging activities, and its protective potential against iron and tert-butyl hydroperoxide-induced damage to mitochondria...
February 20, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28237493/low-ph-induced-reversible-reorganizations-of-chloroplast-thylakoid-membranes-as-revealed-by-small-angle-neutron-scattering
#14
Renáta Ünnep, Ottó Zsiros, Zsolt Hörcsik, Márton Markó, Anjana Jajoo, Joachim Kohlbrecher, Győző Garab, Gergely Nagy
Energization of thylakoid membranes brings about the acidification of the lumenal aqueous phase, which activates important regulatory mechanisms. Earlier Jajoo and coworkers (2014 FEBS Lett. 588:970) have shown that low pH in isolated plant thylakoid membranes induces changes in the excitation energy distribution between the two photosystems. In order to elucidate the structural background of these changes, we used small-angle neutron scattering on thylakoid membranes exposed to low p(2)H (pD) and show that gradually lowering the p(2)H from 8...
February 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28236753/salt-stress-reduces-kernel-number-of-corn-by-inhibiting-plasma-membrane-h-atpase-activity
#15
Stephan Jung, Birgit W Hütsch, Sven Schubert
Salt stress affects yield formation of corn (Zea mays L.) at various physiological levels resulting in an overall grain yield decrease. In this study we investigated how salt stress affects kernel development of two corn cultivars (cvs. Pioneer 3906 and Fabregas) at and shortly after pollination. In an earlier study, we found an accumulation of hexoses in the kernel tissue. Therefore, it was hypothesized that hexose uptake into developing endosperm and embryo might be inhibited. Hexoses are transported into the developing endosperm by carriers localized in the plasma membrane (PM)...
February 9, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28206793/do-positive-spontaneous-thoughts-function-as-incentive-salience
#16
Elise L Rice, Barbara L Fredrickson
The present work explores the theoretical relationship between positive spontaneous thoughts and incentive salience-a psychological property thought to energize wanting and approach motivation by rendering cues that are associated with enjoyment more likely to stand out to the individual when subsequently encountered in the environment (Berridge, 2007). We reasoned that positive spontaneous thoughts may at least be concomitants of incentive salience, and as such, they might likewise mediate the effect of liking on wanting...
February 16, 2017: Emotion
https://www.readbyqxmd.com/read/28199904/cyclic-electron-flow-may-provide-some-protection-against-psii-photoinhibition-in-rice-oryza-sativa-l-leaves-under-heat-stress
#17
Jemaa Essemine, Yi Xiao, Mingnan Qu, Hualing Mi, Xin-Guang Zhu
Previously we have shown that a quick down-regulation in PSI activity compares to that of PSII following short-term heat stress for two rice groups including C4023 and Q4149, studied herein. These accessions were identified to have different natural capacities in driving cyclic electron flow (CEF) around PSI; i.e., low CEF (lcef) and high CEF (hcef) for C4023 and Q4149, respectively. The aim of this study was to investigate whether these two lines have different mechanisms of protecting photosystem II from photodamage under heat stress...
April 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28188726/the-roles-of-v-type-h-atpase-and-na-k-atpase-in-energizing-k-and-h-transport-in-larval-drosophila-gut-epithelia
#18
Natalie M D'Silva, Andrew Donini, Michael J O'Donnell
We analyzed V-type H(+)-ATPase (VA) and Na(+)/K(+)-ATPase (NKA) along the caeca and midgut of third instar Drosophila larvae using immunohistochemistry and ATPase activity assays. Corresponding H(+) and K(+) fluxes were characterized using the Scanning Ion-Selective Electrode Technique (SIET), and the roles of transport ATPases in energizing ion transport across the larval gut were investigated by basal application of bafilomycin, a VA inhibitor, and ouabain, a NKA inhibitor. Addition of bafilomycin led to a decrease in H(+) absorption along the caeca and midgut except at the copper cells and large flat cell zone of the middle midgut...
February 7, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28167264/surface-modified-particles-loaded-with-camkii-inhibitor-protect-cardiac-cells-against-mitochondrial-injury
#19
Amaraporn Wongrakpanich, Angie S Morris, Sean M Geary, Mei-Ling A Joiner, Aliasger K Salem
An excess of calcium (Ca(2+)) influx into mitochondria during mitochondrial re-energization is one of the causes of myocardial cell death during ischemic/reperfusion injury. This overload of Ca(2+) triggers the mitochondrial permeability transition pore (mPTP) opening which leads to programmed cell death. During the ischemic/reperfusion stage, the activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) enzyme is responsible for Ca(2+) influx. To reduce CaMKII-related cell death, sub-micron particles composed of poly(lactic-co-glycolic acid) (PLGA), loaded with a CaMKII inhibitor peptide were fabricated...
March 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28135573/retinal-venous-blood-carbon-monoxide-response-to-bright-light-in-male-pigs-a-preliminary-study
#20
Dan A Oren, Magdalena Duda, Katarzyna Kozioł, Maria Romerowicz-Misielak, Anna Koziorowska, Przemysław Sołek, Sławomir Nowak, Magdalena Kulpa, Marek Koziorowski
The physical mechanism by which light is absorbed in the eye and has antidepressant and energizing effects in Seasonal Affective Disorder and other forms of psychiatric major depression is of scientific interest. This study was designed to explore one specific aspect of a proposed humoral phototransduction mechanism, namely that carbon monoxide (CO) levels increase in retinal venous blood in response to bright light. Eleven mature male pigs approximately six months of age were kept for 7days in darkness and fasted for 12h prior to surgery...
January 21, 2017: Journal of Photochemistry and Photobiology. B, Biology
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