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https://www.readbyqxmd.com/read/29148432/a-singular-value-decomposition-linear-programming-svdlp-optimization-technique-for-circular-cone-based-robotic-radiotherapy
#1
Bin Liang, Yongbao Li, Wei Ran, Bin Guo, Xuang Xu, Bo Liu, Jiafeng Li, Qiuwen Wu, Fugen Zhou
With robot-controlled linac positioning, the robotic radiotherapy system such as CyberKnife significantly increases the freedom in radiation beam placement, but also imposes more challenges on treatment plan optimization. The resampling mechanism in vendor supplied treatment planning system (MultiPlan) could not fully explore the increased beam direction search space. Besides, a sparse treatment plan (using fewer beams) is desired to improve the treatment efficiency. This study proposes a singular value decomposition linear programming (SVDLP) optimization technique for circular collimator based robotic radiotherapy...
November 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29145553/tumour-boards-in-geriatric-oncology
#2
Tanya Marya Wildes, Anita O'Donovan, Giuseppe Ferdinando Colloca, Kwok-Leung Cheung
Multidisciplinary tumour board is an integral part of cancer treatment planning. Although no definite survival benefits have yet been shown by mostly observational studies, other benefits of multidisciplinary tumour board have been identified. Traditionally the multidisciplinary tumour board involves participation of treating clinicians-medical, radiation and surgical oncologists. They tend to focus on the cancer alone. There is an increasing awareness that the treatment goal for cancer in older adults is not primarily on prolonging survival, with functional preservation and quality of life being particularly important for this population...
November 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29143875/the-role-of-18f-fdg-pet-ct-and-pet-mri-in-pancreatic-ductal-adenocarcinoma
#3
Randy Yeh, Laurent Dercle, Ishan Garg, Zhen Jane Wang, David M Hough, Ajit H Goenka
Pancreatic ductal adenocarcinoma (PDAC) remains a difficult disease to treat and continues to portend a poor prognosis, as most patients are unresectable at diagnosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with CT (PET/CT) has been a cornerstone in oncological imaging of different cancers; however, the role of PET/CT in PDAC is continually evolving and currently not well established. Studies have shown the potential of PET/CT in guiding the management of patients with PDAC, with possible added benefit over anatomic imaging with CT or MRI in certain scenarios...
November 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29141779/five-field-imrt-class-solutions-and-dosimetric-planning-guidelines-for-implementing-accelerated-partial-breast-irradiation
#4
Sarah Quirk, Petra Grendarova, Michael Roumeliotis
PURPOSE: A comprehensive set of planning guidelines was developed to aid in achieving reproducible dosimetric results for external beam accelerated partial breast irradiation (APBI). The methodology for the development of class solutions for dosimetric planning of the APBI technique, including dose constraint recommendations, is presented for target coverage and conformity as well as normal tissues. METHODS AND MATERIALS: A conservative patient setup was simulated on a linear accelerator, and a comprehensive arrangement of gantry and couch angles was measured for clearance...
September 28, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29139208/a-knowledge-based-approach-to-automated-planning-for-hepatocellular-carcinoma
#5
Yujie Zhang, Tingting Li, Han Xiao, Weixing Ji, Ming Guo, Zhaochong Zeng, Jianying Zhang
PURPOSE: To build a knowledge-based model of liver cancer for Auto-Planning, a function in Pinnacle, which is used as an automated inverse intensity modulated radiation therapy (IMRT) planning system. METHODS AND MATERIALS: Fifty Tomotherapy patients were enrolled to extract the dose-volume histograms (DVHs) information and construct the protocol for Auto-Planning model. Twenty more patients were chosen additionally to test the model. Manual planning and automatic planning were performed blindly for all twenty test patients with the same machine and treatment planning system...
November 15, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29135471/first-patients-treated-with-a-1-5-t-mri-linac-clinical-proof-of-concept-of-a-high-precision-high-field-mri-guided-radiotherapy-treatment
#6
B W Raaymakers, I M Jürgenliemk-Schulz, G H Bol, M Glitzner, A N T J Kotte, B van Asselen, J C J de Boer, J J Bluemink, S L Hackett, M A Moerland, S J Woodings, J W H Wolthaus, H M van Zijp, M E P Philippens, R Tijssen, J G M Kok, E N de Groot-van Breugel, I Kiekebosch, L T C Meijers, C N Nomden, G G Sikkes, P A H Doornaert, W S C Eppinga, N Kasperts, L G W Kerkmeijer, J H A Tersteeg, K J Brown, B Pais, P Woodhead, J J W Lagendijk
The integration of 1.5 T MRI functionality with a radiotherapy linear accelerator (linac) has been pursued since 1999 by the UMC Utrecht in close collaboration with Elekta and Philips. The idea behind this integrated device is to offer unrivalled, online and real-time, soft-tissue visualization of the tumour and the surroundings for more precise radiation delivery. The proof of concept of this device was given in 2009 by demonstrating simultaneous irradiation and MR imaging on phantoms, since then the device has been further developed and commercialized by Elekta...
November 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29132644/delineating-sites-of-failure-following-post-prostatectomy-radiation-treatment-using-68-ga-psma-pet
#7
Keelan Byrne, Thomas Eade, Andrew Kneebone, Linxin Guo, Ed Hsiao, Geoff Schembri, Carolyn Kwong, Julia Hunter, Louise Emmett, George Hruby
PURPOSE: To identify sites of failure with (68)Ga-PSMA-PET (PSMA-PET) imaging in patients who have Biochemical Failure (BF) following post-prostatectomy radiotherapy. MATERIAL AND METHODS: Between June 2006 and January 2016, 409 men received post prostatectomy intensity modulated radiation treatment (IMRT) with protocolised planning. 310 patients received radiation treatment (RT) to the Prostate Fossa (PF) alone and 99 patients received RT to PF and pelvic lymphatics (PF + LN) usually in combination with androgen deprivation (AD) therapy...
November 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29131409/field-size-correction-factors-of-a-radiophotoluminescent-glass-dosimeter-for-small-field-and-intensity-modulated-radiation-therapy-beams
#8
Shimpei Hashimoto, Yukio Fujita, Tetsurou Katayose, Hideyuki Mizuno, Hidetoshi Saitoh, Katsuyuki Karasawa
PURPOSE: We evaluated the energy responses of a radiophotoluminescent glass dosimeter (RPLD) to variations in small-field and intensity-modulated radiation therapy (IMRT) conditions using experimental measurements and Monte Carlo simulation. METHODS: Several sizes of the jaw and multileaf collimator fields and various plan-class IMRT-beam measurements were performed using the RPLD and an ionization chamber. The field-size correction factor for the RPLD was determined for 6- and 10-MV X-rays...
November 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29129125/clinical-efficacy-and-safety-of-a-highly-conformal-supine-hybrid-forward-and-inverse-planned-intensity-modulated-radiation-therapy-technique-for-craniospinal-irradiation
#9
Safia K Ahmed, Jon J Kruse, Thomas B Bradley, Chris J Beltran, Nadia N Issa Laack
PURPOSE: To demonstrate the clinical efficacy and safety of a highly conformal, supine, hybrid forward and inverse planned intensity modulated radiation therapy (IMRT) technique for photon craniospinal irradiation (CSI). METHODS: Patients who received supine, hybrid IMRT CSI from 2009 to 2014 were included in this retrospective review. Clinical target volume (CTV) was defined as intracranial contents and thecal sac, including nerve roots. Dose was prescribed such that >99% of CTV received >99% of prescription and >95% of the planning target volume received >95% of prescription, with no attempt to include vertebral bodies...
November 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29128934/radiobiological-analysis-of-stereotactic-body-radiation-therapy-for-an-evidence-based-planning-target-volume-of-the-lung-using-multiphase-ct-images-obtained-with-a-pneumatic-abdominal-compression-apparatus-a-case-study
#10
Arun Chairmadurai, Harish Chandra Goel, Sandeep Kumar Jain, Pawan Kumar
This study evaluated the efficiency of stereotactic body radiation therapy of lung (SBRT-Lung) in generating a treatment volume using conventional multiple-phase three-dimensional computed tomography (3D-CT) of a patient immobilized with pneumatic abdominal compression. The institutional protocol for SBRT-Lung using the RapidArc technique relied on a planning target volume (PTV) delineated using 3D-CT and accounted for linear and angular displacement of the tumor during respiratory movements. The efficiency of the institutional protocol was compared with that of a conventional method for PTV delineation based on radiobiological estimates, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), evaluated using dose-volume parameters...
November 11, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29128008/practical-tips-for-mr-imaging-of-perineural-tumor-spread
#11
REVIEW
Claudia F E Kirsch, Ilona M Schmalfuss
Perineural tumor spread (PNS) substantially alters a patient's prognosis and treatment plan. Therefore, it is critical that the radiologists are familiar with the course of cranial nerves commonly affected by PNS and the neuronal connections to appropriately map the extent of PNS. Limited involvement of a nerve by PNS might be resectable, whereas advanced PNS may require radiation therapy.
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29127435/intensified-preoperative-chemoradiation-by-adding-oxaliplatin-in-locally-advanced-primary-operable-ct3nxm0-rectal-cancer-impact-on-long-term-outcome-results-of-the-phase%C3%A2-ii-tako-05-abcsg-r%C3%A2-02-trial
#12
P Kogler, A F DeVries, W Eisterer, J Thaler, L Sölkner, D Öfner
PURPOSE: The major goals of preoperative treatment for locally advanced rectal cancers (LARCs) are improvement of local tumor control, tumor downsizing, and downstaging. Modifications with respect to standardized chemoradiation protocol, e. g., integrating oxaliplatin, are realized with the aim of improving primary tumor response and patient outcome. PATIENTS AND METHODS: In this phase II multicenter study, patients with LARC of the mid- or lower rectum, cT3cNxcM0 as staged by MRI, were included and treated preoperatively with a combination of capecitabine and oxaliplatin following a standardized protocol during radiation...
November 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29126489/dental-treatment-planning-for-the-patient-with-oral-cancer
#13
REVIEW
Lauren E Levi, Rajesh V Lalla
Oral cancer therapy is associated with a multitude of head and neck sequelae that includes, but is not limited to, hyposalivation, increased risk for dental caries, osteoradionecrosis of the jaw, radiation fibrosis syndrome, mucositis, chemotherapy-induced neuropathy, dysgeusia, dysphagia, mucosal lesions, trismus, and infections. Preparing a comprehensive treatment plan for patients undergoing cancer therapy is essential to help minimize their risks for developing these oral and dental complications. In addition, dentists must take into account a patient's ongoing oncologic therapy for those patients who present to the dentist while concurrently receiving cancer treatment...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29126446/detection-level-and-pattern-of-positive-lesions-using-psma-pet-ct-for-staging-prior-to-radiation-therapy
#14
Nina-Sophie Schmidt-Hegemann, Wolfgang Peter Fendler, Alexander Buchner, Christian Stief, Paul Rogowski, Maximilian Niyazi, Chukwuka Eze, Minglun Li, Peter Bartenstein, Claus Belka, Ute Ganswindt
BACKGROUND: To determine the potential role of (68)Ga-PSMA positron emission tomography/computed tomography (PET/CT) in radiotherapy (RT) planning for prostate cancer (PCa). METHODS: One hundred twenty-nine patients (pts) with (68)Ga-PSMA PET/CT were retrospectively analysed. Potentially influencing factors (androgen deprivation therapy, amount of (68)Ga-PSMA-HBED-CC, PSA doubling time ≤/> 10 months, PSA before PET/CT, T-/N-category and Gleason score) were evaluated by logistic regression analysis...
November 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29123573/conformity-index-and-homogeneity-index-of-the-postoperative-whole-breast-radiotherapy
#15
Deva Petrova, Snezana Smickovska, Emilija Lazarevska
BACKGROUND: The treatment of breast cancer involves a multidisciplinary approach in which radiotherapy plays a key role. AIM: The conformity index and the homogeneity index are two analysis tools of a treatment plan using conformal radiotherapy. The purpose of this article is an analysis of these two parameters in the assessment of the treatment plans in 58 patients undergoing postoperative radiotherapy of the whole breast. MATERIALS AND METHODS: All 58 patients participating in the study had a conservatively treated early-stage breast cancer...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29123013/-68-ga-psma-pet-ct-mapping-of-prostate-cancer-biochemical-recurrence-following-radical-prostatectomy-in-270-patients-with-psa-1-0ng-ml-impact-on-salvage-radiotherapy-planning
#16
Jérémie Calais, Johannes Czernin, Minsong Cao, Amar U Kishan, John V Hegde, Narek Shaverdian, Kiri A Sandler, Fang-I Chu, Chris R King, Michael L Steinberg, Isabel Rausher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P Fendler, Matthias Eiber, Nicholas G Nickols
Background: Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography ((68)Ga-PSMA-11 PET/CT) detects recurrent PCa with sensitivity superior to standard of care imaging at serum prostate specific antigen (PSA) values low enough to impact target volume delineations for routine SRT. OBJECTIVE: To i) map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with (68)Ga-PSMA-11 PET/CT in patients with serum PSA levels <1 ng/ml, ii) determine how often consensus clinical target volumes (CTV) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover (68)Ga-PSMA-11 PET/CT-defined disease, and iii) assess the potential impact of (68)Ga-PSMA-11 PET/CT on SRT...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29122556/effect-of-imaging-frequency-on-ptv-margins-and-geographical-miss-during-image-guided-radiation-therapy-for-prostate-cancer
#17
Meetakshi Gupta, Poonam Gamre, Sadhana Kannan, Ganesh Rokde, Rahul Krishnatry, Vedang Murthy
BACKGROUND: The relationship between frequency of imaging during image guided radiation therapy (IGRT) and planning target volume (PTV) margin remains unclear. This issue is of practical significance given resource and time intensive nature of IGRT. The purpose of this study was to evaluate PTV margins with predefined and commonly used less-than-daily IGRT schedules using data obtained from patients treated with daily IGRT for prostate cancer. METHODS AND MATERIALS: Daily setup error and 3-dimensional daily alignment data for a total of 108 consecutive patients with prostate cancer treated with 2700 fractions of daily image guidance on tomotherapy were retrospectively analyzed...
October 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29121945/potential-dosimetric-benefits-of-adaptive-tumor-tracking-over-the-internal-target-volume-concept-for-stereotactic-body-radiation-therapy-of-pancreatic-cancer
#18
Konstantina Karava, Stefanie Ehrbar, Oliver Riesterer, Johannes Roesch, Stefan Glatz, Stephan Klöck, Matthias Guckenberger, Stephanie Tanadini-Lang
BACKGROUND: Radiotherapy for pancreatic cancer has two major challenges: (I) the tumor is adjacent to several critical organs and, (II) the mobility of both, the tumor and its surrounding organs at risk (OARs). A treatment planning study simulating stereotactic body radiation therapy (SBRT) for pancreatic tumors with both the internal target volume (ITV) concept and the tumor tracking approach was performed. The two respiratory motion-management techniques were compared in terms of doses to the target volume and organs at risk...
November 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29121047/dosimetric-comparison-of-ct-guided-iodine-125-seed-stereotactic-brachytherapy-and-stereotactic-body-radiation-therapy-in-the-treatment-of-nsclc
#19
Ranran Li, Ying Zhang, Yuan Yuan, Qi Lin, Jianjian Dai, Ruicai Xu, Xudong Hu, Mingyong Han
This study aimed to assess the dosimetric differences between iodine-125 seed stereotactic brachytherapy (SBT) and stereotactic body radiation therapy (SBRT) in the treatment of non-small cell lung cancer (NSCLC). An SBT plan and an SBRT plan were generated for eleven patients with T1-2 NSCLC. Prescription of the dose and fractionation (fr) for SBRT was 48Gy/4fr. The planning aim for SBT was D90 (dose delivered to 90% of the target volume)≥120Gy. Student's paired t test was used to compare the dosimetric parameters...
2017: PloS One
https://www.readbyqxmd.com/read/29120662/comparison-of-mri-visualisation-between-linearly-placed-iron-containing-and-non-iron-containing-fiducial-markers-for-prostate-radiotherapy
#20
Osamu Tanaka, Hisao Komeda, Masayoshi Tamaki, Kensaku Seike, Shota Fujimoto, Eiichi Yama, Shigeki Hirose, Masayuki Matsuo
OBJECTIVE: Visualising the gold marker (GM) in CT and MRI is critical, especially for registration in high-precision radiotherapy. GM sizes vary. Large markers are easily visualised in MRI. Small GMs show fewer artefacts in CT but are harder to detect in MRI because the signal is influenced by metal in MRI. Therefore, we compared MRI visualisation between linearly placed new iron-containing marker and non-iron containing marker. METHODS: Twenty-seven patients underwent CT/MRI fusion-based intensity-modulated radiotherapy...
November 9, 2017: British Journal of Radiology
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