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https://www.readbyqxmd.com/read/28425920/development-of-a-fast-monte-carlo-dose-calculation-system-for-online-adaptive-radiation-therapy-quality-assurance
#1
Yuhe Wang, Thomas Mazur, Justin Park, Deshan Yang, Sasa Mutic, H Harold Li
Online adaptive radiation therapy (ART) based on real-time magnetic resonance imaging represents a paradigm-changing treatment scheme. However, conventional quality assurance (QA) methods based on phantom measurements are not feasible with the patient on the treatment couch. The purpose of this work is to develop a fast Monte Carlo system for validating online re-optimized tri-60Co IMRT adaptive plans with both high accuracy and speed. The Monte Carlo system is based on Dose Planning Method (DPM) code with further simplification of electron transport and consideration of external magnetic fields...
April 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28425348/integration-of-functional-mri-and-white-matter-tractography-in-cyberknife-radiosurgery
#2
Lu Sun, Baolin Qu, Jinyuan Wang, Zhongjian Ju, Zizhong Zhang, Zhiqiang Cui, Yang Jack, Zhipei Ling, Xinguang Yu, Longsheng Pan
PURPOSE: To investigate the efficacy of the integration of functional magnetic resonance imaging and diffusion-tensor imaging tractography data into CyberKnife radiosurgery for intracranial tumor management. MATERIALS AND METHODS: Functional neuroimaging, anatomical magnetic resonance imaging, and computed tomography images of patients with brain lesions in critical areas were acquired before radiosurgery. The acquired data sets were coregistered using the MIM image fusion software module and then were imported into the CyberKnife Robotic Radiosurgery System (Multiplan 4...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28424876/extent-of-surgical-resection-and-adjuvant-temozolomide-improves-survival-in-pediatric-gbm-a-single-center-experience
#3
Subhash Gupta, Supriya Mallick, Rony Benson, K P Haresh, Pramod Kumar Julka, Goura Kishor Rath
BACKGROUND: Pediatric glioblastoma (pGBM) is an uncommon entity. The importance of concurrent and adjuvant temozolomide is not known in this subset of patients. METHODS: We retrospectively analyzed our database between 2000 and 2015. All patients were treated with maximally safe surgical resection. This was followed by a uniform treatment schedule of post-operative radiation with concurrent daily temozolomide at 75 mg/m(2). Radiation dose was 60 Gy in 30 fractions planned by 3-dimensional conformal radiotherapy...
April 19, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28424830/-when-is-a-nonsurgical-approach-possible-for-metastatic-primary-tumors-and-lymph-node-metastases-of-the-urinary-bladder-and-prostate
#4
R Fietkau
For metastatic carcinomas of the urinary bladder and prostate, systemic therapy is of primary importance. Due to technological advances in radiation oncology such as stereotactic radiotherapy, intensity-modulated radiotherapy, interstitial radiotherapy, and the combination of radiotherapy and chemotherapy, pelvic irradiation can nowadays be carried out effectively and without the risk of major side effects. New data from other tumor entities and retrospective analyses suggest that the use of these technologies can lead to a clinical benefit in terms of improvement in quality of life, local control, and overall survival...
April 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28423530/patterns-of-failure-and-clinical-outcomes-of-definitive-radiotherapy-for-cervical-esophageal-cancer
#5
Lina Zhao, Yongchun Zhou, Yunfeng Mu, Guangjin Chai, Feng Xiao, Lina Tan, Steven H Lin, Mei Shi
PURPOSE: Because of the scarcity of cervical esophageal cancer (CEC), data for this disease entity is limited. We aim to evaluate the outcomes, prognostic factors and failure patterns of CEC treated by contemporary radiotherapy (RT). METHODS: We retrospectively analyzed 86 CEC patients consecutively treated between 2007 and 2015 by definitive RT with or without concurrent chemotherapy. RT was mainly delivered with Intensity Modulated Irradiation Therapy (IMRT) or Volumetric-Modulated Arc Therapy (VMAT)...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421483/update-on-embolization-therapies-for-hepatocellular-carcinoma
#6
REVIEW
Sirish Kishore, Tamir Friedman, David C Madoff
PURPOSE OF REVIEW: The purpose of the review is to summarize the latest applications for embolotherapy in the management of patients with HCC according to BCLC stage. RECENT FINDINGS: While traditionally reserved for patients with unresectable HCC and stage B disease, there is an important role for embolization therapies in earlier stage patients as an adjunct to ablation, bridging, or downstaging therapy, as a means to improve safety of resection, and potentially as an arterial ablative option in the case of radioembolization...
June 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28420598/1-5-t-augmented-reality-navigated-interventional-mri-paravertebral-sympathetic-plexus-injections
#7
David R Marker, Paweena U Thainual, Tamas Ungi, Aaron J Flammang, Gabor Fichtinger, Iulian I Iordachita, John A Carrino, Jan Fritz
PURPOSE: The high contrast resolution and absent ionizing radiation of interventional magnetic resonance imaging (MRI) can be advantageous for paravertebral sympathetic nerve plexus injections. We assessed the feasibility and technical performance of MRI-guided paravertebral sympathetic injections utilizing augmented reality navigation and 1.5 T MRI scanner. METHODS: A total of 23 bilateral injections of the thoracic (8/23, 35%), lumbar (8/23, 35%) and hypogastric (7/23, 30%) paravertebral sympathetic plexus were prospectively planned in twelve human cadavers using a 1...
April 18, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28419482/fmea-of-manual-and-automated-methods-for-commissioning-a-radiotherapy-treatment-planning-system
#8
Amy Wexler, Bruce Gu, Sreekrishna Goddu, Maya Mutic, Sridhar Yaddanapudi, Lindsey Olsen, Taylor Harry, Camille Noel, Todd Pawlicki, Sasa Mutic, Bin Cai
PURPOSE: To evaluate the level of risk involved in treatment planning system (TPS) commissioning using a manual test procedure, and to compare the associated process-based risk to that of an automated commissioning process (ACP) by performing an in-depth failure modes and effects analysis (FMEA). METHODS: The authors collaborated to determine the potential failure modes of the TPS commissioning process using 1) approaches involving manual data measurement, modeling, and validation tests HYPERLINK \l "Fra98" 1, HYPERLINK \l "Smi15" 2 and 2) an automated process utilizing application programming interface (API) scripting, pre-loaded and pre-modeled standard radiation beam data, digital heterogeneous phantom, and an automated commissioning test suite (ACTS)...
April 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28419357/stereoelectroencephalography-using-magnetic-resonance-angiography-for-avascular-trajectory-planning-technical-report
#9
Krasimir Minkin, Kaloyan Gabrovski, Marin Penkov, Yuri Todorov, Rositsa Tanova, Yoana Milenova, Kiril Romansky, Petia Dimova
BACKGROUND: Stereoelectroencephalography (SEEG) requires high-quality angiographic studies because avascular trajectory planning is a prerequisite for the safety of this procedure. Some epilepsy surgery groups have begun to use computed tomography angiography and magnetic resonance T1-weighted sequence with contrast enhancement for this purpose. OBJECTIVE: To present the first series of patients with avascular trajectory planning of SEEG based on magnetic resonance angiography (MRA)...
April 13, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28419246/quality-assurance-for-a-multicenter-phase-ii-study-of-stereotactic-ablative-radiotherapy-for-hepatocellular-carcinoma-%C3%A2-5-cm-a-planning-dummy-run
#10
Sun Hyun Bae, Mi-Sook Kim, Won Il Jang, Kum Bae Kim, Kwang Hwan Cho, Woo Chul Kim, Chang Yeol Lee, Eun Seog Kim, Chul Won Choi, A Ram Chang, Sunmi Jo, Jin-Young Kim
Objective: The Korean Radiation Oncology Group (12-02) investigated the outcome of stereotactic ablative radiotherapy for hepatocellular carcinoma ≤5 cm using 60 Gy in three fractions. To evaluate dosimetric differences and compliance in a multicenter trial, a planning dummy run procedure was performed. Methods: All six participating institutions were provided the contours of two dummy run cases. Plans were performed following the study protocol to cover the planning target volume with a minimum of 90% of the prescription dose and to satisfy the constraints for organs at risk...
April 13, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28417100/data-for-trots-the-radiotherapy-optimisation-test-set
#11
Sebastiaan Breedveld, Ben Heijmen
The Radiotherapy Optimisation Test Set (TROTS) is an extensive set of problems originating from radiotherapy (radiation therapy) treatment planning. This dataset is created for 2 purposes: (1) to supply a large-scale dense dataset to measure performance and quality of mathematical solvers, and (2) to supply a dataset to investigate the multi-criteria optimisation and decision-making nature of the radiotherapy problem. The dataset contains 120 problems (patients), divided over 6 different treatment protocols/tumour types...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28414799/comprehensive-evaluation-of-ten-deformable-image-registration-algorithms-for-contour-propagation-between-ct-and-cone-beam-ct-images-in-adaptive-head-neck-radiotherapy
#12
Xin Li, Yuyu Zhang, Yinghua Shi, Shuyu Wu, Yang Xiao, Xuejun Gu, Xin Zhen, Linghong Zhou
Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) for propagating contours between planning computerized tomography (CT) images and treatment CT/cone-beam CT (CBCT) images to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR) contour mapping, ten intensity-based DIR strategies, which were classified into four categories-optical flow-based, demons-based, level-set-based and spline-based-were tested on planning CT and fractional CBCT images acquired from twenty-one head & neck (H&N) cancer patients who underwent 6~7-week intensity-modulated radiation therapy (IMRT)...
2017: PloS One
https://www.readbyqxmd.com/read/28413798/treatment-planning-challenges-for-prosthesis-prostate-cancer-patients-in-radiation-therapy
#13
N Adhikari, Dinesh Babu Pandey
No abstract text is available yet for this article.
January 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28412775/defining-value-in-radiation-oncology-approaches-to-weighing-benefits-vs-costs
#14
REVIEW
Andre A Konski
The passage of the Affordable Care Act in 2010 initiated discussion regarding transitioning from a fee-for-service arrangement of care reimbursement to value-based care. Cost-effectiveness analysis (CEA) has been used in the past to quantify value as it relates to the provision of healthcare. New treatments or techniques being compared with other new or existing therapies or approaches to care were determined to be cost-effective if the incremental cost-effectiveness ratio was less than $50,000/life-year or quality-adjusted life-year...
April 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28412761/preoperative-assessment-of-hepatocellular-carcinoma-with-split-bolus-combined-phase-contrast-enhanced-computed-tomography
#15
Jian Jiang, Ke Wang, Yufeng Xu, Jianxin Liu, Jingjing Luo, Xin Tao, Xiaoying Wang
BACKGROUND The aim of this study was to investigate the feasibility of a split-bolus combined phase contrast-enhanced computed tomography protocol in evaluation of liver vasculature in hepatocellular carcinoma (HCC) patients for the purpose of surgery guidance. MATERIAL AND METHODS Two groups of patients were recruited for the study: 24 consecutive cases of HCC who underwent multiphasic CT examination, and 22 consecutive cases who afterwards underwent split-bolus combined phase CT examination. The multiphasic protocol included an unenhanced scan and 3 image acquisitions after contrast injection...
April 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28410691/quantification-of-the-uncertainties-of-a-biological-model-and-their-impact-on-variable-rbe-proton-treatment-plan-optimization
#16
A F Resch, G Landry, F Kamp, G Cabal, C Belka, J J Wilkens, K Parodi, G Dedes
PURPOSE: In proton radiation therapy, a relative biological effectiveness (RBE) equal to 1.1 is currently assumed, although biological experiments show that it is not constant. The purpose of this study was to quantify the uncertainties of a published biological model and explore their impact on variable RBE treatment plan (TP) optimization. METHODS: Two patient cases with a high and a low (α/β)x tumor were investigated. Firstly, intensity modulated proton therapy TPs assuming constant RBE were derived, and subsequently the variable RBE weighted dose (RWD), including the uncertainty originating in the fit to the experimental data and the uncertainty of the (α/β)x, were calculated...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28410687/the-evaluation-of-the-feasibility-of-carotid-sparing-intensity-modulated-radiation-therapy-technique-for-comprehensive-breast-irradiation
#17
Ozge Petek Erpolat, Muge Akmansu, Serap Catli Dinc, Koray Akkan, Huseyin Bora
PURPOSE: To investigate the feasibility of carotid sparing intensity modulated radiation therapy (CS-IMRT) to minimize the radiation dose to carotid arteries for comprehensive irradiation of breast cancer patients who have risk factors for atherosclerosis. The dose distribution of CS-IMRT technique and the conventional irradiation technique were also compared. PATIENTS AND METHODS: Ten patients who were previously treated with comprehensive three-dimensional conformal radiation therapy (3DCRT) were selected...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28410686/relations-between-doses-cumulated-in-bone-marrow-and-dose-delivery-techniques-during-radiation-therapy-of-cervical-and-endometrial-cancer
#18
Agata Jodda, Bartosz Urbański, Tomasz Piotrowski, Julian Malicki
PURPOSE: To compare normal tissue complication probability (NTCP) and average doses in the bone marrow (BM), obtained for five different radiotherapy delivery and planning strategies of cervical and endometrial cancer. MATERIAL/METHODS: 50 patients were taken to analysis. For each case, 3 different dose delivery techniques were used: 4-field, X15MV, 3DCRT; 7-field, X6MV, IMRT; and 2-arc, X6MV, VMAT. Two optimization scenarios were used for the IMRT and VMAT plans generation: with (+) and without (-) the inclusion of the BM as an optimized structure...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28410682/integrated-digital-tomosynthesis-for-patient-positioning-of-image-guided-radiation-therapy
#19
Hui Yan, Jian-Rong Dai
PURPOSE: Digital Tomosynthesis (DTS), originally developed for diagnostic applications, has been recently introduced to image guided radiotherapy (IGRT). Due to limited scan range, DTS was featured by anisotropic spatial resolution. A new approach, integrated DTS (IDTS), was developed to improve image resolution of DTS for patient positioning in IGRT. MATERIALS AND METHODS: For registration purpose, both on-board IDTS (O-IDTS) and reference IDTS (R-IDTS) were required...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28408649/external-arrhythmia-ablation-using-photon-beams-ablation-of-the-atrioventricular-junction-in-an-intact-animal-model
#20
H Immo Lehmann, Amanda J Deisher, Mitsuru Takami, Jon J Kruse, Limin Song, Sarah E Anderson, Jack T Cusma, Kay D Parker, Susan B Johnson, Samuel J Asirvatham, Robert C Miller, Michael G Herman, Douglas L Packer
BACKGROUND: This study sought to investigate external photon beam radiation for catheter-free ablation of the atrioventricular junction in intact pigs. METHODS AND RESULTS: Ten pigs were randomized to either sham irradiation or irradiation of the atrioventricular junction (55, 50, 40, and 25 Gy). Animals underwent baseline electrophysiological evaluation, cardiac gated multi-row computed tomographic imaging for beam delivery planning, and intensity-modulated radiation therapy...
April 2017: Circulation. Arrhythmia and Electrophysiology
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