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https://www.readbyqxmd.com/read/29330550/a-metabolomics-pilot-study-on-desmoid-tumors-and-novel-drug-candidates
#1
Kelly A Mercier, Mushriq Al-Jazrawe, Raymond Poon, Zachery Acuff, Benjamin Alman
Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The majority of desmoid tumors are related to T41A and S45F mutations of the beta-catenin encoding gene (CTNNB1). Using broad spectrum metabolomics, differences were investigated between paired normal fibroblast and desmoid tumor cells from affected patients...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329998/common-error-pathways-seen-in-the-ro-ils-data-that-demonstrate-opportunities-for-improving-treatment-safety
#2
Gary Ezzell, Bhisham Chera, Adam Dicker, Eric Ford, Louis Potters, Lakshmi Santanam, Sheri Weintraub
PURPOSE: The Radiation Oncology Incident Learning System (RO-ILS) receives event reports from facilities across the country. This effort extracted common error pathways seen in the data. These pathways, expressed as fault trees, demonstrate the need for, and opportunities for, preventing these errors and/or limiting their propagation to treatment. METHODS AND MATERIALS: As of the third quarter of 2016, 2344 event reports had been submitted to RO-ILS and reviewed...
January 9, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29328046/spatiotemporal-radiotherapy-planning-using-a-global-optimization-approach
#3
Ali Adibi, Ehsan Salari
This paper aims at quantifying the extent of potential therapeutic gain, measured using biologically effective dose (BED), that can be achieved by altering the radiation dose distribution over treatment sessions in fractionated radiotherapy. To that end, a spatiotemporally integrated planning approach is developed, where the spatial and temporal dose modulations are optimized simultaneously. The concept of equivalent uniform BED (EUBED) is used to quantify and compare the clinical quality of spatiotemporally heterogeneous dose distributions in target and critical structures...
January 12, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29325801/editorial-the-role-of-medical-physics-in-lung-sbrt
#4
EDITORIAL
Pietro Mancosu, Andrew Nisbet, Núria Jornet
Stereotactic body radiation therapy (SBRT) has become a standard treatment for non-operable patients with early stage non-small cell lung cancer (NSCLC). In this context, medical physics community has largely helped in the starting and the growth of this technique. In fact, SBRT requires the convergence of many different features for delivering large doses in few fractions to small moving target in an heterogeneous medium. The special issue of last month, was focused on the different physics challenges in lung SBRT...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29324911/psychological-consideration-in-patients-with-cerebral-gliomas-candidates-for-intra-operative-radiation-therapy-based-on-tumor-location
#5
Tohid Emami Meybodi, Masoumeh Najafi, Ali Keipourfard, Amir Nikouei, Afsoun Seddighi
OBJECTIVE: Intra-operative Radiation Therapy (IORT) is gaining popularity as an adjuvant option to surgical resection, in treatment of glioblastoma multiforme (GBM) for increasing survival rate, which a highly aggressive cerebral tumor with poor prognosis. Τhe authors plan to investigate the effects of IORT combined with surgical resection on the psychological status of these patients based on tumor location. SUBJECT AND METHODS: From December 2013 to February 2017, we have enrolled 109 patients with high grade cerebral gliomas, documented by Magnetic Resonance Spectroscopy (MRS)...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324556/observer-variation-in-the-delineation-of-organs-at-risk-for-head-and-neck-radiation-therapy-treatment-planning-a-systematic-review-protocol
#6
Alisha Moore
The objective of this review is to examine inter- and intra-observer agreement and reliability in the delineation of head and neck organs at risk (OAR) as part of the radiation therapy treatment planning process.More specifically, the objectives are to identify.
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29323550/assessing-the-effect-of-weight-based-protocol-modifications-to-lower-dose-for-ct-guided-hepatic-and-renal-tumor-radiofrequency-ablations
#7
Supriya Gupta, Ronald S Arellano, Debra A Gervais, Dushyant V Sahani
OBJECTIVE: This study assessed radiation dose after CT-guided percutaneous radiofrequency ablations (RFAs) of hepatic and renal tumors and the effect of weight-based CT protocol modification for lowering overall dose in these procedures. MATERIALS AND METHODS: CT-guided RFA for renal and hepatic ablations performed from January 1, 2009, through December 31, 2009, were retrospectively reviewed (90 men and 48 women; age, 42-81 years). The radiation dose was recorded during each of the following steps: planning, performing, and postprocedure...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29322072/plan-in-2-d-execute-in-3-d-an-augmented-reality-solution-for-cup-placement-in-total-hip-arthroplasty
#8
Javad Fotouhi, Clayton P Alexander, Mathias Unberath, Giacomo Taylor, Sing Chun Lee, Bernhard Fuerst, Alex Johnson, Greg Osgood, Russell H Taylor, Harpal Khanuja, Mehran Armand, Nassir Navab
Reproducibly achieving proper implant alignment is a critical step in total hip arthroplasty procedures that has been shown to substantially affect patient outcome. In current practice, correct alignment of the acetabular cup is verified in C-arm x-ray images that are acquired in an anterior-posterior (AP) view. Favorable surgical outcome is, therefore, heavily dependent on the surgeon's experience in understanding the 3-D orientation of a hemispheric implant from 2-D AP projection images. This work proposes an easy to use intraoperative component planning system based on two C-arm x-ray images that are combined with 3-D augmented reality (AR) visualization that simplifies impactor and cup placement according to the planning by providing a real-time RGBD data overlay...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29316969/proton-and-helium-ion-radiotherapy-for-meningioma-tumors-a-monte-carlo-based-treatment-planning-comparison
#9
Thomas Tessonnier, Andrea Mairani, Wenjing Chen, Paola Sala, Francesco Cerutti, Alfredo Ferrari, Thomas Haberer, Jürgen Debus, Katia Parodi
BACKGROUND: Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain and ocular meningiomas with protons and helium ions, using for the first time a dedicated Monte Carlo (MC) based treatment planning engine (MCTP) thoroughly validated both in terms of physical and biological models. METHODS: Starting from clinical treatment plans of four patients undergoing proton therapy with a fixed relative biological effectiveness (RBE) of 1...
January 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29316270/robot-guided-stereoelectroencephalography-without-a-computed-tomography-scan-for-referencing-analysis-of-accuracy
#10
Andrea Spyrantis, Adriano Cattani, Adam Strzelczyk, Felix Rosenow, Volker Seifert, Thomas M Freiman
OBJECTIVE: Recent studies with robot-guided stereotaxy use computed tomography (CT) scans for referencing. We will provide evidence that using preoperative MRI datasets referenced with a laser scan of the patient's face is sufficient for sEEG implantation. METHODS: In total, 40 sEEG electrodes were implanted in five patients by the robotic surgical assistant (ROSA). The postoperative CT scan for identifying electrode positions was fused with the preoperative MRI-based planning data...
January 8, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29316134/dosimetric-benefit-of-adaptive-radiotherapy-in-the-neoadjuvant-management-of-canine-and-feline-thymoma-an-exploratory-case-series
#11
C Rohrer Bley, V Meier, U Schneider
While surgery is the treatment of choice for thymomas, complete excision is not possible in a significant proportion of cases. For these patients, radiotherapy can be used as neoadjunctive, post-operative adjunctive or sole therapy. During radiotherapy, rapid biological clearance of tumour cells is often observed, requiring adaptation of the treatment plan. Adaptive radiation therapy (RT) is a dynamic process, whereby the treatment plan is altered throughout the treatment course due to changes in morphologic, functional or positioning changes...
January 8, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29314051/water-equivalent-presage%C3%A2-for-synchrotron-radiation-therapy-dosimetry
#12
Frank M Gagliardi, Liam Day, Christopher M Poole, Rick D Franich, Moshi Geso
PURPOSE: Synchrotron Radiation Therapy techniques are currently being trialled and commissioned at synchrotrons around the world. The patient treatment planning systems (TPS) developed for these treatments use simulated data of the synchrotron x-ray beam to produce the dosimetry in the treatment plan. The purpose of this study was to investigate a water equivalent PRESAGE® dosimeter capable of 3D dosimetry over an energy range suitable for synchrotron x-ray beams. METHODS: Water equivalent PRESAGE® dosimeters were fabricated with a radiological effective atomic number similar to water over an energy range of 10 keV to 10 MeV...
January 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29313654/lung-cancer-clinical-presentation-and-diagnosis
#13
Kelly M Latimer
In the absence of screening, most patients with lung cancer are not diagnosed until later stages, when the prognosis is poor. The most common symptoms are cough and dyspnea, but the most specific symptom is hemoptysis. Digital clubbing, though rare, is highly predictive of lung cancer. Symptoms can be caused by the local tumor, intrathoracic spread, distant metastases, or paraneoplastic syndromes. Clinicians should suspect lung cancer in symptomatic patients with risk factors. The initial study should be chest x-ray, but if results are negative and suspicion remains, the clinician should obtain a computed tomography scan with contrast...
January 2018: FP Essentials
https://www.readbyqxmd.com/read/29312634/experimental-verification-of-a-3d-in-vivo-dose-monitoring-system-based-on-epid
#14
Xiaoyong Wang, Lixin Chen, Conghua Xie, Dajiang Wang, Gaili Chen, Zhengming Fu, Hui Liu
Purpose: To evaluate the Edose system, a novel three-dimensional (3D) in vivo dose monitoring system based on electronic portal imaging device (EPID), prior to clinical application, we analyzed the preliminary clinical data using Edose system in patients receiving intensity-modulated radiation therapy (IMRT). Materials and methods: After the physical modeling, the measured results from the Edose system were examined in homogeneous and inhomogeneous phantoms, respectively...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29309676/survival-impact-of-postoperative-radiotherapy-timing-in-pediatric-and-adolescent-medulloblastoma
#15
Alexander L Chin, Everett J Moding, Sarah S Donaldson, Iris C Gibbs, Scott G Soltys, Susan M Hiniker, Erqi L Pollom
Background: Radiation therapy (RT) remains a critical component of multimodality treatment for medulloblastoma. Traditionally, clinicians strive to start RT within 4-5 weeks of surgery, but the optimal timing after surgery remains unclear. Methods: Using the National Cancer Database, we identified pediatric and adolescent patients with medulloblastoma treated with curative-intent surgery, RT, and chemotherapy. Factors associated with early or delayed RT were identified using Pearson chi-squared tests...
January 4, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29307445/plan-quality-comparison-between-4-arc-and-6-arc-noncoplanar-volumetric-modulated-arc-stereotactic-radiotherapy-for-the-treatment-of-multiple-brain-metastases
#16
Kotaro Yoshio, Toshiharu Mitsuhashi, Akihisa Wakita, Takahiro Kitayama, Kento Hisazumi, Daisaku Inoue, Tsuyoki Shiode, Shiro Akaki, Susumu Kanazawa
To compare the plans of 4-arc and 6-arc noncoplanar volumetric modulated arc stereotactic radiotherapy (VMA-SRT) for multiple brain metastases and to investigate the cutoff value for the tumor number and volume for 6-arc rather than 4-arc VMA-SRT. We identified 24 consecutive multiple-target cases (3 to 19 targets in each case) with 189 total targets. We constructed plans using both 4- and 6-arc noncoplanar VMA-SRT. The prescribed dose was 36 Gy/6 fr, and it was delivered to 95% of the planning target volume (PTV)...
January 4, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29306538/comparison-of-calculated-dose-distributions-reported-as-dose-to-water-and-dose-to-medium-for-intensity-modulated-radiotherapy-of-nasopharyngeal-cancer-patients
#17
Ðeni Smilović Radojčić, Manda Švabić Kolacio, Milan Radojčić, David Rajlić, Božidar Casar, Dario Faj, Slaven Jurković
Advanced dose calculation algorithms for radiation therapy treatment planning can report external beam photon dose 2-sided, in terms of dose-to-medium (Dm) and dose-to-water (Dw). The purpose of our study was to determinate the effect of Dw and Dm reporting modes built in Elekta Monaco treatment planning system on intensity-modulated radiotherapy dose distributions for patients with nasopharyngeal cancer. For 13 patients involved in this retrospective study, 2 plans were created: 1 using Dw and another according to Dm reporting mode...
January 4, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29306379/variation-assessment-of-deformable-registration-in-stereotactic-radiosurgery
#18
C-S Chang, R Shih, J-M Hwang, K-S Chuang
INTRODUCTION: The regular functions of CT-MRI registration include delineation of targets and organs-at-risk (OARs) in radiosurgery planning. The question of whether deformable image registration (DIR) could be applied to stereotactic radiosurgery (SRS) in its place remains a subject of debate. METHODS: This study collected data regarding 16 patients who had undergone single-fraction SRS treatment. All lesions were located close to the brainstem. CT and MRI two image sets were registered by both rigid image registration (RIR) and DIR algorithms...
February 2018: Radiography
https://www.readbyqxmd.com/read/29305806/wintertime-carbonaceous-aerosols-over-dhauladhar-region-of-north-western-himalayas
#19
Deepika Kaushal, Ajay Kumar, Shweta Yadav, Ankit Tandon, Arun K Attri
Carbonaceous aerosols play an important role in affecting human health, radiative forcing, hydrological cycle, and climate change. As our current understanding about the carbonaceous aerosols, the source(s) and process(es) associated with them in the ecologically sensitive North-Western Himalayas are limited; this systematic study was planned to understand inherent dynamics in the mass concentration and source contribution of carbonaceous aerosols in the Dhauladhar region. During four winter months (January 2015-April 2015), 24-h PM10 samples were collected every week simultaneously at the rural site of Pohara (32...
January 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29304901/indoor-tanning-a-gianus-bifrons-vitamin-d-and-human-cancer
#20
Giuseppe Lippi, Gianfranco Cervellin, Elisa Danese
Despite it is now undeniable that indoor tanning exposure is associated with a number of skin cancers, its favorable effects on vitamin D status may bear some underestimated and currently unexplored health benefits. Vitamin D is a fat-soluble vitamin naturally present in a limited number of foods, the concentration of which largely depends on ultraviolet (UV) B sources exposure in humans. A strong, graded, and inverse association has been documented between serum vitamin D and the risk of developing certain types of malignancy, especially colorectal, breast, lung, bladder, and kidney cancers...
2018: Advances in Clinical Chemistry
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