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https://www.readbyqxmd.com/read/28944998/enhanced-immune-response-induced-by-p5-her2-neu-derived-peptide-pulsed-dendritic-cells-as-a-preventive-cancer-vaccine
#1
Zahra Gholizadeh, Jalil Tavakkol-Afshari, Amin Reza Nikpoor, Seyed Amir Jalali, Mahmoud Reza Jaafari
Dendritic cells are special and powerful antigen-presenting cells that can induce primary immune responses against tumour-associated antigens. They can present antigens via both MHC-I and MHC-II, so they have the ability to stimulate both cytotoxic T lymphocytes and T helper cells. Furthermore, CD8(+) cytotoxic T lymphocytes require activation by CD4(+) T cells. This requires a CD4(+) T cell activator molecule, of which PADRE is one of the best. We chose an approach to use both of these important arms of the immune system...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944986/development-and-in-vitro-in-vivo-evaluation-of-a-novel-benznidazole-liquid-dosage-form-using-a-quality-by-design-approach
#2
Higo Fernando Santos Souza, Daniel Real, Darío Leonardi, Sandra Carla Rocha, Victoria Alonso, Esteban Serra, Ariel Mariano Silber, Claudio Javier Salomon
OBJECTIVES: To develop an alcohol-free solution suitable for children of benznidazole, the drug of choice for treatment of Chagas disease. METHODS: In a quality-by-design approach a systematic optimization procedure was carried out in order to estimate the values of the factors leading to the maximum drug concentration. The formulations were analyzed in terms of chemical and physical stability and drug content. The final preparation was subjected to an in-vivo palatability assay...
September 25, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28944979/dosimetric-validation-of-monaco-treatment-planning-system-on-an-elekta-versahd-linear-accelerator
#3
Ganesh Narayanasamy, Daniel L Saenz, Dewayne Defoor, Niko Papanikolaou, Sotirios Stathakis
The purpose of this study is to perform dosimetric validation of Monaco treatment planning system version 5.1. The Elekta VersaHD linear accelerator with high dose rate flattening filter-free photon modes and electron energies was used in this study. The dosimetric output of the new Agility head combined with the FFF photon modes warranted this investigation into the dosimetric accuracy prior to clinical usage. A model of the VersaHD linac was created in Monaco TPS by Elekta using commissioned beam data including percent depth dose curves, beam profiles, and output factors...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944759/optimization-of-an-ultralow-dose-high-resolution-pediatric-pet-scanner-design-based-on-monolithic-scintillators-with-dual-sided-digital-sipm-readout-a-simulation-study
#4
Ekaterina Mikhaylova, Valerio Tabacchini, Giacomo Borghi, Pieter Mollet, Ester D'Hoe, Dennis R Schaart, Stefaan Vandenberghe
The goal of this simulation study is the performance evaluation and comparison of six potential designs for a time-of-flight PET scanner for pediatric patients of up to about 12 years of age. It is designed to have a high sensitivity and provide high-contrast and high-resolution images. The simulated pediatric PET is a full ring scanner, consisting of 32 × 32 mm<sup>2</sup> monolithic LYSO:Ce crystals coupled to digital silicon photomultiplier (dSiPM) arrays. The six considered designs differ in axial lengths (27...
September 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28944738/an-industry-update-the-latest-developments-in-therapeutic-delivery
#5
Oliver C Steinbach
The present industry update covers the period 1-30 June 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. The combination of drug and devices such as improved, safer injectables (see various market reports, companies Adamis and Baxter), patches (Microdermis) and (nano)carriers are moving increasingly from the R&D stage into clinical trials and toward the market. This addresses increased safety and effectiveness requirements, limiting physico-chemical properties of active ingredients, cost-effectiveness and patient comfort through ease of use...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944714/gymnemic-acids-lozenge-reduces-short-term-consumption-of-high-sugar-food-a-placebo-controlled-experiment
#6
Eric Stice, Sonja Yokum, Jeff M Gau
Gymnemic acids (GA) suppress sweet taste and reduce consumption of high-sugar foods (HSF) which has been attributed to the reduction in pleasure. Herein we tested whether GA reduces the desire to eat HSF, before any HSF is tasted post GA dosing, which would implicate another mechanism of action not previously examined. In this double-blind experiment, 67 adults selected a favourite candy, consumed one standardized serving, rated candy pleasantness along with desire for more candy, and were randomly assigned to consume a GA or placebo lozenge...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28944563/a-randomized-controlled-trial-of-levodopa-in-patients-with-angelman-syndrome
#7
Wen-Hann Tan, Lynne M Bird, Anjali Sadhwani, Rene L Barbieri-Welge, Steven A Skinner, Lucia T Horowitz, Carlos A Bacino, Lisa M Noll, Cary Fu, Rachel J Hundley, Logan K Wink, Craig A Erickson, Gregory N Barnes, Anne Slavotinek, Rita Jeremy, Alexander Rotenberg, Sanjeev V Kothare, Heather E Olson, Annapurna Poduri, Mark P Nespeca, Hillary C Chu, Jennifer M Willen, Kevin F Haas, Edwin J Weeber, Paul A Rufo
Treatment for Angelman syndrome (AS) is currently limited to symptomatic interventions. A mouse model of AS has reduced calcium/calmodulin-dependent kinase II activity due to excessive phosphorylation of specific threonine residues, leading to diminished long-term potentiation. In a rat model of Parkinson disease, levodopa reduced phosphorylation of various proteins, including calcium/calmodulin-dependent kinase II. Further studies demonstrated that AS mice treated with levodopa performed better on rotarod testing than untreated AS mice...
September 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28944554/limited-potential-of-cebranopadol-to-produce-opioid-type-physical-dependence-in-rodents
#8
Thomas M Tzschentke, Babette Y Kögel, Stefanie Frosch, Klaus Linz
Cebranopadol is a novel potent analgesic agonist at the nociceptin/orphanin FQ peptide (NOP) and classical opioid receptors. As NOP receptor activation has been shown to reduce side effects related to the activation of μ-opioid peptide (MOP) receptors, the present study evaluated opioid-type physical dependence produced by cebranopadol in mice and rats. In a naloxone-precipitated withdrawal assay in mice, a regimen of seven escalating doses of cebranopadol over 2 days produced only very limited physical dependence as evidenced by very little withdrawal symptoms (jumping) even at cebranopadol doses clearly exceeding the analgesic dose range...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944496/the-unidirectional-hypoxia-activated-prodrug-oct1002-inhibits-growth-and-vascular-development-in-castrate-resistant-prostate-tumors
#9
Heather Nesbitt, Jenny Worthington, Rachel J Errington, Laurence H Patterson, Paul J Smith, Stephanie R McKeown, Declan J McKenna
BACKGROUND: OCT1002 is a unidirectional hypoxia-activated prodrug (uHAP) OCT1002 that can target hypoxic tumor cells. Hypoxia is a common feature in prostate tumors and is known to drive disease progression and metastasis. It is, therefore, a rational therapeutic strategy to directly target hypoxic tumor cells in an attempt to improve treatment for this disease. Here we tested OCT1002 alone and in combination with standard-of-care agents in hypoxic models of castrate-resistant prostate cancer (CRPC)...
September 24, 2017: Prostate
https://www.readbyqxmd.com/read/28944361/cone-beam-computed-tomography-with-ultra-low-dose-protocols-for-pre-implant-radiographic-assessment-an-in-vitro-study
#10
Robert Liljeholm, Nils Kadesjö, Daniel Benchimol, Kristina Hellén-Halme, Xie-Qi Shi
PURPOSE: To evaluate the ultra-low dose scanning protocols of a newly developed CBCT for pre-implant radiographic assessment. MATERIALS AND METHODS: A total number of 32 CBCT scans were exposed at 90 kV using ProMax 3D's standard (GS) and three ultra-low dose scanning protocols: high, mid and low definition (UL-HD, UL-MD and UL-LD) on eight human dry skulls with simulated soft tissue. The mAs values and the voxel size were 96mAs/200 µm, 28mAs/150 µm, 22.4mAs/200 µm and 7...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28944326/the-anti-inflammatory-effect-of-hydrogen-sulphide-on-acute-necrotizing-pancreatitis-in-rats
#11
Kutay Sağlam, Etem Alhan, Serdar Türkyılmaz, Birgül Kural Vanizor, Cengiz Erçin
OBJECTIVE: The aim of this study was to investigate the dose-dependent anti-inflammatory effect of the Hydrogen sulfidedonor sodiumhydrosulphide on acute necrotizing pancreatitis in rats. MATERIAL AND METHODS: A total of 42 male Sprague-Dawley rats were divided into 4 groups: sham+saline (group 1), sham+NaHS (group 2), acute necrotizing pancreatitis+saline (group 3), and acute necrotizing pancreatitis+NaHS (group 4). Acute pancreatitis was induced in rats in groups 3 and 4 with the infusion of glycodeoxycholic acidinto the biliopancreatic canal and infusion of cerulein parenterally...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944123/preventing-cushing-iatrogenic-cushing-syndrome-due-to-ritonavir-fluticasone-interaction
#12
Fasil Tiruneh, Ahmad Awan, Abiot Didana, Saumil Doshi
Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been treated with inhaled fluticasone, who presented with back pain. He had central obesity, prominent abdominal striae and wasted extremities on physical examination...
July 17, 2017: Curēus
https://www.readbyqxmd.com/read/28944056/magnetic-resonance-guided-high-intensity-focused-ultrasound-in-the-presence-of-biopsy-markers
#13
Charles Mougenot, Chrit Moonen
BACKGROUND: Magnetic Resonance guided High Intensity Focused ultrasound (MR-HIFU) offers precise non-invasive thermotherapy for clinical applications such as the treatment of breast lesions. However, patients with a biopsy marker are usually not eligible for MR-HIFU treatment. This study investigates the interaction of some MR-compatible markers with MR-HIFU thermotherapy. METHODS: The MR-HIFU compatibility of 14 markers (6 Gold Anchor and 4 Visicoil markers in gold, 1 Visicoil marker in brass, 3 BiomarC markers in carbon coated) were tested using the Sonalleve breast MR-HIFU platform at 1...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28944001/recurrent-graves-hyperthyroidism-after-prolonged-radioiodine-induced-hypothyroidism
#14
REVIEW
Fariha Salman, Hooman Oktaei, Solomon Solomon, Ebenezer Nyenwe
BACKGROUND: Radioactive iodine (RAI) is the most cost effective therapy for Graves' disease (GD). Patients with GD who have become hypothyroid after therapeutic RAI, rarely develop recurrence of disease. Herein we describe a case of recurrence of thyrotoxicosis after 2 years of hypothyroidism. METHODS: We present the clinical features, laboratory findings, imaging and management of an unusual case of recurrent hyperthyroidism. RESULTS: A 48-year-old male presented to the emergency room with a 2-day history of palpitation, chest discomfort and 30 pounds of weight loss...
July 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28943978/impact-of-targeted-educational-interventions-on-appropriateness-of-stress-ulcer-prophylaxis-in-critically-ill-adults
#15
Drayton A Hammond, Catherine A Killingsworth, Jacob T Painter, Rose E Pennick, Kshitij Chatterjee, Bradley Boye, Nikhil Meena
BACKGROUND: Acid suppression therapy (AST) is routinely used in critically ill patients to prevent stress-related mucosal bleeding (SRMB). OBJECTIVE: Our objective was to determine the impact of a structured educational intervention on AST used for prevention of SRMB on appropriateness of AST. METHODS: A single-center, retrospective, cohort study of appropriate use of AST in critically ill patients admitted to the medical intensive care unit (ICU) at an academic medical center between January to June of 2014 (no intervention) and January to June of 2015 (intervention) was conducted...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943870/gastrointestinal-tract-as-entry-route-for-hantavirus-infection
#16
Peter T Witkowski, Casey C Perley, Rebecca L Brocato, Jay W Hooper, Christian Jürgensen, Jörg-Dieter Schulzke, Detlev H Krüger, Roland Bücker
Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion of PUUV-infected patients suffer from gastrointestinal symptoms of unclear origin. In this study we demonstrate that PUUV infection can occur via the alimentary tract. Methods: We investigated susceptibility of the human small intestinal epithelium for PUUV infection and analyzed the resistance of virions to gastric juice...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28943850/withanolide-d-exhibits-similar-cytostatic-effect-in-drug-resistant-and-drug-sensitive-multiple-myeloma-cells
#17
Mark E Issa, E M K Wijeratne, A A L Gunatilaka, Muriel Cuendet
In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtually all conventional therapies. In this study, the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera, on drug-sensitive tumoral plasma cells and drug-resistant MM cells have been investigated...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28943825/can-a-short-video-improve-inhaler-use-in-urban-youth
#18
Sara Brown, Victoria Tutag Lehr, Nathan French, Christopher Alan Giuliano
OBJECTIVE: The primary aim was to determine whether watching a short video in the inpatient setting could produce an immediate improvement in pediatric patients' asthma knowledge and inhaler technique. METHODS: This prospective, quasi-experimental, pre-post study was conducted in a single center, in Detroit, Michigan, which primarily serves an urban, African-American population. Patients were eligible if they were between 8- and 16-years-old, had asthma, and would be discharged with an albuterol metered-dose inhaler...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28943819/evaluation-of-safety-in-exceeding-maximum-adult-doses-of-commonly-used-second-generation-antiepileptic-drugs-in-pediatric-patients
#19
Mindl M Messinger, Sunita N Misra, Gary D Clark, Shannon M DiCarlo
OBJECTIVE: Pediatric patients often require larger doses of antiepileptic drug (AED) than adults in order to attain therapeutic serum concentrations and/or achieve seizure control. Safety and efficacy data are often extrapolated from adult literature; hence, optimal dosage may only be determined anecdotally or based on expert opinion. With limited pediatric dosing guidelines, milligrams per day that are based on weight may exceed the maximum adult dose. The primary objective of this study is to evaluate the safety of exceeding maximum doses as specified by the US Food and Drug Administration or manufacturers of commonly used AEDs in pediatric patients...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28943720/host-plant-location-by-the-guatemalan-potato-moth-tecia-solanivora-is-assisted-by-floral-volatiles
#20
Miriam Frida Karlsson, Magali Proffit, Göran Birgersson
Insects locate their host plants using mainly visual and olfactory cues, generally of the exploited plant structure. However, when the resource is difficult to access, it could be beneficial to utilise indirect cues, which indicates the presence of reward (e.g., oviposition site or mate). In the present study, we investigated the host-plant location strategy of the monophagous Guatemalan potato moth Tecia solanivora (Lepidoptera: Gelechiidae). The larva of the moth feed exclusively on potato Solanum spp. (Solanaceae) tubers usually hidden below ground...
2017: Chemoecology
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