Karin C Wu, Kathryn E McCauley, Susan V Lynch, Renuka R Nayak, Nicole J King, Sheena Patel, Tiffany Y Kim, Katherine Condra, Doug Fadrosh, Dat Nguyen, Din L Lin, Kole Lynch, Stanley J Rogers, Jonathan T Carter, Andrew M Posselt, Lygia Stewart, Anne L Schafer
Laparoscopic sleeve gastrectomy (LSG), the most common bariatric surgical procedure, leads to durable weight loss and improves obesity-related comorbidities. However, it induces abnormalities in bone metabolism. One unexplored potential contributor is the gut microbiome, which influences bone metabolism and is altered after surgery. We characterized the relationship between the gut microbiome and skeletal health in severe obesity and after LSG. In a prospective cohort study, 23 adults with severe obesity underwent skeletal health assessment and stool collection preoperatively and 6 mo after LSG...
January 4, 2024: Journal of Bone and Mineral Research