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https://www.readbyqxmd.com/read/29770924/roux-en-y-gastric-bypass-surgery-induced-weight-loss-and-metabolic-improvements-are-similar-in-tgr5-deficient-and-wildtype-mice
#1
Zheng Hao, R Leigh Townsend, Michael B Mumphrey, Thomas W Gettys, Sangho Yu, Heike Münzberg, Christopher D Morrison, Hans-Rudolf Berthoud
BACKGROUND AND PURPOSE: Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective treatments for obesity and type 2 diabetes. Despite this, the mechanisms through which it acts are still not well understood. Bile acid signaling through the transmembrane G-protein-coupled receptor TGR5 has been shown to have significant effects on metabolism and has recently been reported to be necessary for the full effects of vertical sleeve gastrectomy (VSG), a bariatric surgery with similar effects to RYGB...
May 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29768729/adaptive-changes-in-pancreas-post-roux-en-y-gastric-bypass-induced-weight-loss
#2
A Lautenbach, M Wernecke, N Riedel, J Veigel, J Yamamura, S Keller, R Jung, P Busch, O Mann, F K Knop, J J Holst, J J Meier, J Aberle
AIMS: Obesity has been shown to trigger adaptive increases in pancreas parenchymal and fat volume. Consecutively, pancreatic steatosis may lead to beta-cell dysfunction. However, it is not known, whether the pancreatic tissue components decrease with weight loss and pancreatic steatosis is reversible following RYGB. Therefore, the objective of the study was to investigate the effects of RYGB-induced weight loss on pancreatic volume and glucose homeostasis. MATERIALS AND METHODS: 11 patients were recruited in the Obesity Centre of the University Medical Centre Hamburg-Eppendorf...
May 16, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29766305/evaluation-of-vte-prophylaxis-and-the-impact-of-alternate-regimens-on-post-operative-bleeding-and-thrombotic-complications-following-bariatric-procedures
#3
Maria S Altieri, Jie Yang, Janos Hajagos, Konstantinos Spaniolas, Jihye Park, Antonios P Gasparis, Andrew T Bates, Salvatore Docimo, Mark Talamini, A Laurie Shroyer, Aurora D Pryor
BACKGROUND: Studies examining utilization and impact of venous thromboembolism (VTE) chemoprophylaxis for patients undergoing bariatric surgery are limited. Determination of the optimal prophylactic regimen to minimize complications is crucial. METHODS: The Cerner Health Facts database from 2003 to 2013 was queried using ICD-9 codes to identify patients undergoing laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB). VTE chemoprophylaxis regimens were divided into pre-operative alone (PreP), post-operative alone (PostP), both pre-operative and post-operative (PPP), or no prophylaxis (NP)...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29761876/differential-gip-glp-1-intestinal-cell-distribution-in-diabetics-yields-distinctive-rearrangements-depending-on-roux-en-y-biliopancreatic-limb-length
#4
António M Palha, Sofia S Pereira, Madalena M Costa, Tiago Morais, André F Maia, Marta Guimarães, Mário Nora, Mariana P Monteiro
As incretins are known to play an important role in type 2 diabetics (T2D) improvement observed after Roux-en-Y gastric bypass (RYGB), our aim was to assess whether increasing the length of RYGB biliopancreatic limb in T2D would modify the incretin staining cell density found after the gastric outlet. Small intestine biopsies (n = 38) were harvested during RYGB at two different distances from the duodenal angle; either 60-90 cm (n = 28), from non-diabetic (n = 18) patients, and T2D (n = 10), or 200 cm (n = 10) from T2D...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29756978/comparative-study-of-the-nutritional-status-of-vitamin-a-in-pregnant-women-and-in-women-who-became-pregnant-or-did-not-after-roux-en-y-gastric-bypass
#5
Sabrina Cruz, Suzana Machado, Suelem Cruz, Sílvia Pereira, Carlos Saboya, Andréa Ramalho
INTRODUCTION: the changes in digestive physiology after Roux-en-Y gastric bypass (RYGB), as well as pregnancy, maximizes the risk of vitamin A deficiency (VAD) and both can result in harm to the mother and child health. OBJECTIVE: to compare the nutritional status of vitamin A among women who became pregnant or did not after RYGB and in pregnant women who did not undergo surgery, and to assess the impact of VAD on the mother and child health. METHODS: this is a cross-sectional study of the analytical type...
January 18, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29755786/laparoscopic-assisted-transgastric-ercp-a-single-institution-experience
#6
Katherine Habenicht Yancey, Lauren Katherine McCormack, Stephen Samuel McNatt, Myron Sheavictor Powell, Adolfo Zachariah Fernandez, Carl Joseph Westcott
Background: Laparoscopic-assisted transgastric endoscopic retrograde cholangiopancreatography (LAERCP) is used for treatment in patients after Roux-en-Y gastric bypass (RYGB), where transoral access to the biliary tree is not possible. We describe our technique and experience with this procedure. Methods: Electronic medical record search was performed from September 2012 to January 2016, identifying patients who underwent LAERCP per operative records. Charts were reviewed for demographic, clinical, and outcomes data...
2018: Journal of Obesity
https://www.readbyqxmd.com/read/29754386/nutritional-deficiencies-in-chinese-patients-undergoing-gastric-bypass-and-sleeve-gastrectomy-prevalence-and-predictors
#7
Bingsheng Guan, Jingge Yang, Yanya Chen, Wah Yang, Cunchuan Wang
BACKGROUND: Nutritional deficiencies have been reported in bariatric surgery patients with inconsistent results. However, scarce data exist for Chinese patients. We aimed to assess nutritional deficiencies in Chinese patients undergoing Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), and to identify predictors of postoperative nutritional status. METHODS: A retrospective review of a prospectively collected database was conducted in the patients undergoing RYGB and SG in our hospital between June 2013 and January 2017...
May 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29754264/one-year-impact-of-bariatric-surgery-on-serum-anti-mullerian-hormone-levels-in-severely-obese-women
#8
Clara Vincentelli, Marie Maraninchi, René Valéro, Sophie Béliard, Flavia Maurice, Olivier Emungania, Bruno Berthet, Elise Lombard, Anne Dutour, Bénédicte Gaborit, Blandine Courbiere
INTRODUCTION: Although bariatric surgery seems to increase spontaneous fertility by improving ovulatory function in young women, its impact on ovarian reserve remains largely unknown. OBJECTIVE: To evaluate changes in serum anti-Mullerian hormone (AMH) levels in reproductive-age severely obese women after bariatric surgery (BS). METHODS: AMH levels were measured retrospectively in 39 women (mean age 34.6 ± 1.1 years, range 18-45) that underwent a sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) at baseline, and 6 and 12 months after BS...
May 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29748735/revisional-gastric-bypass-is-inferior-to-primary-gastric-bypass-in-terms-of-short-and-long-term-outcomes-systematic-review-and-meta-analysis
#9
Michał Pędziwiatr, Piotr Małczak, Mateusz Wierdak, Mateusz Rubinkiewicz, Magdalena Pisarska, Piotr Major, Michał Wysocki, W Konrad Karcz, Andrzej Budzyński
PURPOSE: Although Roux-en-Y gastric bypass (RYGB) is the main primary bariatric procedure, it has also been utilized as revisional bariatric surgery. Our aim is to compare revisionary gastric bypass with primary gastric bypass through systematic review with meta-analysis. METHODS: Available literature was searched for eligible studies up to December 2017. Inclusion criteria were reports on morbidity, %EWL, or diabetes remission. Secondary outcomes involved mortality, anastomotic leakage, operative time, and length of hospital stay...
May 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29748734/selection-of-bypass-vs-sleeve-for-the-management-of-type-2-diabetes-in-severely-obese-could-ethnicity-play-a-role
#10
Aparna Govil Bhasker, John B Dixon, Muffazal Lakdawala
PURPOSE: Prospective data was evaluated to see whether bariatric procedure type made any difference to diabetes remission. METHODS: One hundred eighty-six consecutive patients of Indian ethnicity (M:F 89:97) with type 2 diabetes mellitus (T2DM) and HbA1c > 6.5 were assessed before and at 1 year following surgery. Age, BMI, C-peptide and duration of diabetes (ABCD - described by WJ Lee), insulin use, baseline HbA1c, and % weight loss were tested as modifiers...
May 10, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29743040/a-dissonance-based-intervention-for-women-post-roux-en-y-gastric-bypass-surgery-aiming-at-improving-quality-of-life-and-physical-activity-24-months-after-surgery-study-protocol-for-a-randomized-controlled-trial
#11
Fanny Sellberg, Sofie Possmark, Ata Ghaderi, Erik Näslund, Mikaela Willmer, Per Tynelius, Anders Thorell, Magnus Sundbom, Joanna Uddén, Eva Szabo, Daniel Berglind
BACKGROUND: Roux-en-Y gastric bypass (RYGB) surgery is the most common bariatric procedure in Sweden and results in substantial weight loss. Approximately one year post-surgery weight regain for these patient are common, followed by a decrease in health related quality of life (HRQoL) and physical activity (PA). Our aim is to investigate the effects of a dissonance-based intervention on HRQoL, PA and other health-related behaviors in female RYGB patients 24 months after surgery. We are not aware of any previous RCT that has investigated the effects of a similar intervention targeting health behaviors after RYGB...
May 9, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29739229/efficacy-and-safety-of-transoral-outlet-reduction-via-endoscopic-suturing-in-patients-with-weight-regain-after-a-surgical-roux-en-y-gastric-bypass
#12
Eduardo Espinet Coll, Javier Nebreda Durán, Gontrand López-Nava Breviere, Manoel Galvao Neto, José Antonio Gómez Valero, Silvia Bacchiddu, Carmen Vila Lolo, Patricia Díaz Galán, Inmaculada Bautista-Castaño, Antonio Juan-Creix Comamala
INTRODUCTION: many patients that undergo bariatric surgery (Roux-en-Y gastric bypass [RYGB]) may regain some of their weight lost over time. A transoral outlet reduction (TORe) with endoscopic suture could be a valid alternative in these patients. METHODS: this was a retrospective initial series of 13 consecutive patients with weight regain after RYGB and a dilated gastro-jejunal anastomosis (> 15 mm). TORe was performed using an endoscopic transmural suture device (OverStitch-Apollo®), which was used to reduce the anastomosis aperture and also to treat the gastric pouch...
May 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29735346/severe-anemia-after-roux-en-y-gastric-bypass-a-cause-for-concern
#13
Emily McCracken, G Craig Wood, Wesley Prichard, Bruce Bistrian, Christopher Still, Glenn Gerhard, David Rolston, Peter Benotti
BACKGROUND: The current popularity of metabolic surgery has led to increasing attention to long-term nutritional complications. OBJECTIVE: The purpose of this retrospective study is to accurately define the long-term incidence of clinically significant anemia after Roux-en-Y gastric bypass (RYGB) and to identify factors that contribute to increased risk. METHODS: The study cohort consisted of 2116 patients who underwent RYGB with necessary laboratory information available, and with longitudinal follow-up available (mean 5...
March 28, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29732709/restoration-of-enteroendocrine-and-pancreatic-function-after-internal-hernia-and-short-bowel-syndrome-in-a-young-woman-with-gastric-bypass-a-2-year-follow-up
#14
Märta Borghede, Lars Vinter-Jensen, Henrik H Rasmussen, Simon Veedfald, Jens F Rehfeld, Bolette Hartmann, Jens J Holst, Filip K Knop, David P Sonne
A serious complication to the laparoscopic Roux-en-Y gastric bypass (RYGB) is internal hernia, which can lead to massive bowel necrosis that may result in short bowel syndrome. We determined postprandial enteropancreatic hormonal responses and metabolites in a 22-year-old nondiabetic woman with a history of RYGB experiencing severe internal herniation with widespread bowel necrosis. Extensive resections were performed leaving her with a saliva fistula from the pouch-enteric anastomosis, an intact duodenum, 15 cm of jejunum, 35 cm of ileum, and intact colon...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29730732/mechanisms-underlying-the-weight-loss-effects-of-rygb-and-sg-similar-yet-different
#15
REVIEW
A Pucci, R L Batterham
The worldwide obesity epidemic continues unabated, adversely impacting upon global health and economies. People with severe obesity suffer the greatest adverse health consequences with reduced life expectancy. Currently, bariatric surgery is the most effective treatment for people with severe obesity, resulting in marked sustained weight loss, improved obesity-associated comorbidities and reduced mortality. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), the most common bariatric procedures undertaken globally, engender weight loss and metabolic improvements by mechanisms other than restriction and malabsorption...
May 5, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29730228/an-international-multicenter-comparative-trial-of-eus-guided-gastrogastrostomy-assisted-ercp-versus-enteroscopy-assisted-ercp-in-patients-with-roux-en-y-gastric-bypass-anatomy
#16
Majidah Bukhari, Thomas Kowalski, Jose Nieto, Rastislav Kunda, Nitin K Ahuja, Shayan Irani, Apeksha Shah, David Loren, Olaya Brewer, Omid Sanaei, Lea Fayad, Yen-I Chen, Saowanee Ngamruengphong, Vivek Kumbhari, Vikesh Singh, Hanaa Dakour Aridi, Mouen A Khashab
BACKGROUND & AIMS: ERCP is challenging in patients with Roux-en-Y gastric bypass (RYGB) anatomy. EUS-guided gastrogastrostomy (GG) creation is a promising novel technique to access the excluded stomach in order to facilitate conventional ERCP. We aimed to compare procedural outcomes and adverse events (AEs) between EUS-guided gastrogastrostomy-assisted ERCP (EUS-GG-ERCP) and enteroscopy assisted ERCP (e-ERCP) in patients with RYGB. METHODS: Patients with RYGB anatomy who underwent EUS-GG-ERCP or e-ERCP between 2014 and 2016 at 5 tertiary centers were included...
May 3, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29725976/impact-of-weight-regain-on-the-evolution-of-non-alcoholic-fatty-liver-disease-after-roux-en-y-gastric-bypass-a-3-year-follow-up
#17
Laísa Simakawa Jimenez, Fábio Henrique Mendonça Chaim, Felipe David Mendonça Chaim, Murillo Pimentel Utrini, Martinho Antonio Gestic, Elinton Adami Chaim, Everton Cazzo
BACKGROUND: The influence of post-surgical weight regain on the course of non-alcoholic fatty liver disease (NAFLD) is unclear. OBJECTIVE: To evaluate the influence of weight regain on the NAFLD assessed by means of a non-invasive score after Roux-en-gastric bypass (RYGB) over a 3-year period. METHODS: This is a prospective observational cohort study which evaluated individuals who underwent RYGB. Comparisons were made between the periods immediately before surgery and 12, 24, and 36 months following surgery...
May 3, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29724681/incidence-of-cholecystectomy-after-bariatric-surgery
#18
Maria S Altieri, Jie Yang, Lizhou Nie, Salvatore Docimo, Mark Talamini, Aurora D Pryor
BACKGROUND: Bariatric surgery predisposes patients to development of cholelithiasis, and therefore the need of a subsequent cholecystectomy; however, the incidence of cholecystectomy after bariatric surgery is debated. OBJECTIVE: The purpose of our study is to assess the incidence of cholecystectomy after 3 of the most common bariatric procedures. SETTING: University Hospital, involving a large database in New York State. METHODS: The Statewide Planning and Research Cooperative System administrative longitudinal database was used to identify all patients undergoing Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and laparoscopic adjustable gastric banding (LAGB) between 2004 and 2010...
March 30, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29722910/glycemic-management-in-the-bariatric-surgery-population-a-review-of-the-literature
#19
Meredith L Howard, Taylor D Steuber, Sarah A Nisly
Obesity is a worldwide epidemic often complicated by multiple comorbidities, including type 2 diabetes mellitus (T2DM). Bariatric surgery is an increasingly common and effective weight loss strategy for obese patients that may result in resolution of metabolic related disease states, such as T2DM. Although bariatric surgery has many positive outcomes for patients, dietary and pathophysiologic changes can create difficult to control blood glucose, especially in the immediate perioperative setting. Depending on oral antidiabetic agent and insulin needs preoperatively, many patients require cessation of oral agents and reduction or cessation of insulin...
May 3, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29721762/effects-of-diet-on-bile-acid-metabolism-and-insulin-resistance-in-type-2-diabetic-rats-after-roux-en-y-gastric-bypass
#20
Cheng-Xiang Shan, Nian-Cun Qiu, Miao-E Liu, Si-Luo Zha, Xin Song, Zhi-Peng Du, Wen-Sheng Rao, Dao-Zhen Jiang, Wei Zhang, Ming Qiu
BACKGROUND: Roux-en-Y gastric bypass (RYGB) is effective for the treatment of type 2 diabetes mellitus; however, the mechanism remains unclear. METHODS: The effects of RYGB on postprandial responses to three different diets (low carbohydrate (CH)-rich diet, high CH-rich diet, and fat-rich diet) of different nutritional composition in a Goto-Kakizaki (GK) diabetic rat model were assessed by measuring glucose tolerance, insulin resistance, incretin responses, and bile acid (BA) metabolism...
May 2, 2018: Obesity Surgery
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