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https://www.readbyqxmd.com/read/29330917/mitochondrial-respiratory-capacity-remains-stable-despite-a-comprehensive-and-sustained-increase-in-insulin-sensitivity-in-obese-patients-undergoing-gastric-bypass-surgery
#1
Michael T Lund, Steen Larsen, Merethe Hansen, Julie Courraud, Andrea K Floyd, Mikael Støckel, Jørn W Helge, Flemming Dela
AIM: It has been proposed, but not yet demonstrated by convincing evidence in published articles, that insulin resistance and mitochondrial respiratory function are causally-related physiological phenomena. Here, we tested the prediction that weight loss induced increase in insulin sensitivity will correlate with a corresponding change in mitochondrial respiratory capacity over the same time period. METHODS: Insulin sensitivity was evaluated using the hyperinsulinaemic-euglycemic clamp technique and skeletal muscle mitochondrial respiratory capacity was evaluated by high-resolution respirometry in 26 patients with obesity...
January 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29327183/bidirectional-jejunojejunal-anastomosis-prevents-early-small-bowel-obstruction-due-to-the-kinking-after-closure-of-the-mesenteric-defect-in-the-laparoscopic-roux-en-y-gastric-bypass
#2
Pierre Munier, Hefzi Alratrout, Iole Siciliano, Philippe Keller
BACKGROUND: The closure of the mesenteric defects (CMD) in Roux-en-Y gastric bypass (RYGB) reduces the risk of small bowel obstruction (SBO) due to internal hernia but might be associated with an increased risk of early SBO triggered by the jejunojejunal anastomosis (JJS) kinking. The aim of this study was to assess how enlarging the JJS with a bidirectional linear stapling can aid in avoiding the risk of early SBO by kinking. MATERIALS AND METHODS: This retrospective cohort study concerns 1327 patients who underwent RYGB with CMD between May 2007 and August 2016...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29327182/changes-in-iron-absorption-after-roux-en-y-gastric-bypass
#3
Wendy Schijns, Marjolein A P Ligthart, Frits J Berends, Ignace M C Janssen, Cees J H M van Laarhoven, Edo O Aarts, Hans de Boer
INTRODUCTION: Iron deficiency is one of the most common deficiencies that may occur after Roux-en-Y gastric bypass (RYGB). Little is known about the optimal treatment of post-RYGB iron deficiency. AIM: The aim of this study is to evaluate the changes in iron absorption characteristics after RYGB for two oral iron formulations, one presented in tablet form and one as in the form of a solution. METHOD: Iron absorption in 24 obese women was studied before and 1 month after RYGB...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29318504/oral-vitamin-b12-supplementation-after-roux-en-y-gastric-bypass-a-systematic-review
#4
Kamal K Mahawar, Alastair Reid, Yitka Graham, Lindes Callejas-Diaz, Chetan Parmar, William Rj Carr, Neil Jennings, Rishi Singhal, Peter K Small
BACKGROUND: Many respectable guidelines recommend lifelong vitamin B12 injections for Roux-en-Y gastric bypass (RYGB) patients in the absence of lack of consensus on the efficacy of oral route of prophylaxis and the appropriate doses needed for this purpose. The purpose of this review was to examine the published English language scientific literature in accordance with PRISMA principles to find out if orally given vitamin B12 is adequate for prophylactic purposes in RYGB patients and the appropriate dosages needed for this purpose if it is...
January 9, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29317267/spiral-enteroscopy-assisted-ercp-in-bariatric-length-roux-en-y-anatomy-a-large-single-center-series-and-review-of-the-literature-with-video
#5
Mohammad F Ali, Rani Modayil, Krishna C Gurram, Collin Brathwaite, David Friedel, Stavros Stavropoulos
BACKGROUND: Deep enteroscopy-assisted ERCP (DEA-ERCP) in post-bariatric Roux-en-Y (RY) anatomy is challenging. Laparoscopy-assisted ERCP (LA-ERCP) or EUS-directed transgastric ERCP (EDGE) are technically easier and faster, but are more invasive and morbid procedures. Therefore, we have used DEA-ERCP as our first-line approach, reserving EDGE and LA-ERCP for cases in which adjunctive techniques that cannot be performed through an enteroscope are required (eg, EUS-FNA, SO manometry), or DEA-ERCP failures...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29310367/should-roux-en-y-gastric-bypass-biliopancreatic-limb-length-be-tailored-to-achieve-improved-diabetes-outcomes
#6
Mário Nora, Tiago Morais, Rui Almeida, Marta Guimarães, Mariana P Monteiro
The objective is to access the role of Roux-en-Y gastric bypass (RYGB) biliopancreatic limb (BPL) length in type 2 diabetes (T2D) outcomes.RYGB is more effective than medical intervention for T2D treatment in obese patients. Despite the scarcity of available data, previous reports suggest that modifications of the RYGB limb lengths could improve the antidiabetic effects of the surgery.A cohort of obese T2D patients (n = 114) were submitted to laparoscopic RYGB, either with a standard BPL (SBPL) (n = 41; BPL 84 ± 2 cm) or long BPL (LBPL) (n = 73; BPL = 200 cm) and routinely monitored for weight loss and diabetic status up to 5 years after surgery...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29307107/upregulation-of-ghrelin-gene-expression-in-the-excluded-stomach-of-obese-women-with-type-2-diabetes-after-roux-en-y-gastric-bypass-in-the-surmetagit-study
#7
Danielle Cristina Fonseca, Priscila Sala, Joelle Singer, Pierre Singer, Raquel Susana Torrinhas, Dan Linetzky Waitzberg
BACKGROUND: Mechanisms of type 2 diabetes remission (T2Dr) after Roux-en-Y gastric bypass (RYGB) in obese patients appear to involve gastrointestinal hormones. OBJECTIVE: The objective of this study is to explore changes in ghrelin plasma levels and ghrelin gastrointestinal gene expression (GHRL) after RYGB, and their relationships to T2Dr. SETTING: In 20 obese women with T2D, before and 3 months after RYGB, we assessed GHRL expression by microarray and quantitative RT-PCR in gastrointestinal biopsy samples and plasma levels of ghrelin...
January 6, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29306650/common-weight-loss-procedures-and-their-complications
#8
REVIEW
Maria S Altieri, Brian Wright, Andrew Peredo, Aurora D Pryor
BACKGROUND: As the number of obese patients in the United States continues to grow, there is a parallel increase in the number of bariatric surgery patients. A quarter of these patients will return to the Emergency Department (ED) within the first two years of the index procedure. OBJECTIVE: An understanding of the most common bariatric procedures and their related complications will greatly aide the Emergency Medicine physician in the care of these patients. DISCUSSION: Abdominal pain is the most common reason for bariatric patients to present to the ED and can represent a diagnostic challenge to EM physicians...
December 2, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29306011/adaptation-of-human-gut-microbiota-to-bariatric-surgeries-in-morbidly-obese-patients-a-systematic-review
#9
Hanieh-Sadat Ejtahed, Pooneh Angoorani, Shirin Hasani-Ranjbar, Seyed-Davar Siadat, Nasrin Ghasemi, Bagher Larijani, Ahmad-Reza Soroush
BACKGROUND: Bariatric surgeries have turned to be a popular therapeutic option for morbid obesity nowadays. Gut microbiota is supposed to be responsible as a part of the bariatric surgeries success. In this systematic review, we detailed the human studies which investigated the effect of different bariatric surgeries on the composition of gut microbiota. METHODS: We did a comprehensive search in PubMed, Web of Science, and Scopus for all clinical trials and longitudinal observational studies documented up to December 2015...
January 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29305304/sleeve-gastrectomy-surgery-when-2-alcoholic-drinks-are-converted-to-4
#10
María Belén Acevedo, J Christopher Eagon, Bruce D Bartholow, Samuel Klein, Kathleen K Bucholz, Marta Yanina Pepino
BACKGROUND: While it is well established that Roux-en-Y gastric bypass (RYGB) causes a rapid and heightened peak blood alcohol concentration (BAC), results from previous studies on the effects of sleeve gastrectomy (SG) on alcohol pharmacokinetics are conflicting. Data from 2 studies found SG did not affect BAC, whereas another study found SG caused a heightened peak BAC after alcohol ingestion. Moreover, these 3 studies estimated BAC from breathalyzers, which might not reliably estimate peak BAC...
November 10, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29295558/effects-of-sleeve-gastrectomy-vs-roux-en-y-gastric-bypass-on-eating-behavior-and-sweet-taste-perception-in-subjects-with-obesity
#11
Katie Nance, J Christopher Eagon, Samuel Klein, Marta Yanina Pepino
The goal of this study was to test the hypothesis that weight loss induced by Roux-en-Y gastric bypass (RYGB) has greater effects on taste perception and eating behavior than comparable weight loss induced by sleeve gastrectomy (SG). We evaluated the following outcomes in 31 subjects both before and after ~20% weight loss induced by RYGB (n = 23) or SG (n = 8): (1) sweet, savory, and salty taste sensitivity; (2) the most preferred concentrations of sucrose and monosodium glutamate; (3) sweetness palatability, by using validated sensory testing techniques; and (4) eating behavior, by using the Food Craving Inventory and the Dutch Eating Behavior Questionnaire...
December 24, 2017: Nutrients
https://www.readbyqxmd.com/read/29290921/gut-brain-crosstalk-regulates-craving-for-fatty-food
#12
REVIEW
Rajendra Raghow
Patients undergoing Roux-en-Y gastric bypass (RYGB) surgery elicit striking loss of body weight. Anatomical re-structuring of the gastrointestinal (GI) tract, leading to reduced caloric intake and changes in food preference, are thought to be the primary drivers of weight loss in bariatric surgery patients. However, the mechanisms by which RYGB surgery causes a reduced preference for fatty foods remain elusive. In a recent report, Hankir et al described how RYGB surgery modulated lipid nutrient signals in the intestine of rats to blunt their craving for fatty food...
December 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/29290011/the-outcome-of-bariatric-surgery-in-patients-aged-75%C3%A2-years-and-older
#13
Zubaidah Nor Hanipah, Suriya Punchai, Linden A Karas, Samuel Szomstein, Rahul J Rosenthal, Stacy A Brethauer, Ali Aminian, Philip R Schauer
BACKGROUND: Bariatric surgery has been shown to be safe and effective in patients aged 60-75 years; however, outcomes in patients aged 75 or older are undocumented. METHODS: Patients aged 75 years and older who underwent bariatric procedures in two academic centers between 2006 and 2015 were studied. RESULTS: A total of 19 patients aged 75 years and above were identified. Eleven (58%) were male, the median age was 76 years old (range 75-81), and the median preoperative body mass index (BMI) was 41...
December 30, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29289697/guanylin-and-uroguanylin-mrna-expression-is-increased-following-roux-en-y-gastric-bypass-but-guanylins-do-not-play-a-significant-role-in-body-weight-regulation-and-glycemic-control
#14
María L Fernandez-Cachon, Søren L Pedersen, Kristoffer T Rigbolt, Chen Zhang, Katrine Fabricius, Henrik H Hansen, Lisbeth Elster, Lisbeth N Fink, Matthias Schäfer, Nicolai A Rhee, Ebbe Langholz, Erik Wandall, Steffen U Friis, Peter Vilmann, Viggo B Kristiansen, Christina Schmidt, Kay Schreiter, Kristin Breitschopf, Thomas Hübschle, Tina Jorsal, Tina Vilsbøll, Thorsten Schmidt, Stefan Theis, Filip K Knop, Philip Just Larsen, Jacob Jelsing
AIM: To determine whether intestinal expression of guanylate cyclase activator 2A (GUCA2A) and guanylate cyclase activator 2B (GUCA2B) genes is regulated in obese humans following Roux-en-Y gastric bypass (RYGB), and to evaluate the corresponding guanylin (GN) and uroguanylin (UGN) peptides for potentially contributing to the beneficial metabolic effects of RYGB. METHODS: Enteroendocrine cells were harvested peri- and post-RYGB, and GUCA2A/GUCA2B mRNA expression was compared...
December 28, 2017: Peptides
https://www.readbyqxmd.com/read/29281126/effects-of-gastric-bypass-surgery-on-bone-mass-and-microarchitecture-occur-early-and-particularly-impact-postmenopausal-women
#15
Anne L Schafer, Galateia J Kazakia, Eric Vittinghoff, Lygia Stewart, Stanley J Rogers, Tiffany Y Kim, Jonathan T Carter, Andrew M Posselt, Courtney Pasco, Dolores M Shoback, Dennis M Black
Roux-en-Y gastric bypass (RYGB) surgery is a highly effective treatment for obesity but negatively affects the skeleton. Studies of skeletal effects have generally examined areal BMD by DXA, but DXA may be inaccurate in the setting of marked weight loss. Further, as a result of modestly sized samples of mostly premenopausal women and very few men, effects of RYGB by sex and menopausal status are unknown. We prospectively studied the effects of RYGB on skeletal health, including axial and appendicular volumetric BMD and appendicular bone microarchitecture and estimated strength...
December 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29276076/robotic-platform-for-gastric-bypass-is-associated-with-more-resource-utilization-an-analysis-of-mbsaqip-dataset
#16
Gautam Sharma, Andrew T Strong, Chao Tu, Stacy A Brethauer, Philip R Schauer, Ali Aminian
BACKGROUND: The current literature comparing robot-assisted Roux-en-Y gastric bypass (RA-RYGB) and laparoscopic Roux-en-Y gastric bypass (LRYGB) is limited to single center retrospective series. OBJECTIVES: This study aims to compare perioperative outcomes of patients who underwent RA-RYGB with those who underwent LRYGB. SETTING: National database. METHODS: Data on patients who underwent RA-RYGB and LRYGB were extracted from the 2015 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program participant use file...
November 22, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29275093/resting-energy-expenditure-after-roux-en-y-gastric-bypass-surgery
#17
Britta Wilms, Barbara Ernst, Martin Thurnheer, Sebastian M Schmid, Christina M Spengler, Bernd Schultes
BACKGROUND: The mechanisms by which Roux-en Y gastric bypass surgery (RYGB) provokes weight loss are incompletely understood. Enhanced energy expenditure may be one contributing mechanism. Previous results on changes in resting energy expenditure (REE) after RYGB are inconsistent. OBJECTIVES: The aim of the present study was to assess changes in REE after RYGB and whether REE predicts weight loss (percentage weight loss). SETTING: Obesity Clinic...
October 31, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29274838/metabolic-effect-of-foregut-exclusion-demonstrated-by-the-impact-of-gastrogastric-fistula-on-recurrence-of-diabetes
#18
Pichamol Jirapinyo, Andrew C Thompson, Paul T Kröner, Walter W Chan, Christopher C Thompson
BACKGROUND: Type 2 diabetes mellitus (T2DM) resolves in over 80% of patients after Roux-en-Y gastric bypass (RYGB). It has been hypothesized that foregut exclusion is mechanistically important to this observation. This study aims (1) to determine if GG fistula, with a loss of foregut exclusion, is associated with T2DM relapse, and (2) to assess if closure of GG fistula is associated with T2DM resolution. STUDY DESIGN: A matched cohort study of patients who experienced T2DM remission after RYGB...
December 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29273924/changes-in-physical-activities-and-body-composition-after-roux-y-gastric-bypass-surgery
#19
Alex Harley Crisp, Rozangela Verlengia, Michele Novaes Ravelli, Irineu Rasera Junior, Maria Rita Marques de Oliveira
PURPOSE: Given the importance of physical activities for health outcomes, it is still unclear whether bariatric surgery per se and the standard care after surgery would result in an increase of physical activity level. This study aimed to determine physical activities preoperatively and at 6 and 12 months postoperatively among female patients who underwent bariatric surgery, and to investigate its relationship with body composition changes. MATERIAL AND METHODS: Thirty-four women who had Roux-Y gastric bypass (RYGB) surgery completed the study...
December 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29243457/the-surgical-management-of-obesity
#20
Samuel Torres-Landa, Umashankkar Kannan, Isabella Guajardo, Octavia E Pickett-Blakely, Daniel T Dempsey, Noel N Williams, Kristoffel R Dumon
Obesity is a spreading epidemic associated with significant morbidity and mortality with a prevalence of over 36% worldwide. In the face of a growing epidemic, increasing medical costs, and the disappointing limitations of medical and lifestyle modification bariatric surgery was found to consistently lead to significant weight loss and improvement in obesity-associated comorbidities when compared to non-surgical interventions. Bariatric procedures fall within three basic categories: restrictive procedures, malabsorptive procedures, and procedures that combine both restrictive and malabsorptive mechanisms...
December 14, 2017: Minerva Chirurgica
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