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Serena Marcelli, Elena Ficulle, Filomena Iannuzzi, Enikö Kövari, Robert Nisticò, Marco Feligioni
Synaptic dysfunction has been recognized as an early feature occurring at the onset of Alzheimer's disease (AD). Compromised neurotransmission leads over time to synaptic loss and these events correlate with the cognitive decline that progressively affects AD patients.Protein SUMOylation (Small Ubiquitin-like MOdifier) is a post-translational modification (PTM) involved in several cellular processes including synaptic transmission.We here demonstrate that cortical synaptosomes prepared from Tg2576 mice of 6 months of age show an increased SUMO-1ylation, which returns back to normal levels at 20 months although synaptic SUMOylation, at this age, resulted more sensible to KCl stimulus...
October 13, 2016: Molecular Neurobiology
Gisle Langslet, Andrei Breazna, Euridiki Drogari
BACKGROUND: The efficacy and safety of atorvastatin in children/adolescents aged 10-17 years with heterozygous familial hypercholesterolemia (HeFH) have been demonstrated in trials of up to 1 year in duration. However, the efficacy/safety of >1 year use of atorvastatin in children/adolescents with HeFH, including children from 6 years of age, has not been assessed. OBJECTIVE: To characterize the efficacy and safety of atorvastatin over 3 years and to assess the impact on growth and development in children aged 6-15 years with HeFH...
September 2016: Journal of Clinical Lipidology
Shengke Li, Yuan-Fu Ding, Hang Yin, Chunming Wang, David Bardelang, Lian-Hui Wang, Ruibing Wang
As determined by both (1) H NMR and UV/Vis spectroscopic titration, ESI-MS, isothermal titration calorimetry, and DFT molecular modeling, advanced glycation end products (AGE) breaker alagebrium (ALA) formed 1:1 guest-host inclusion complexes with cucurbit[7]uril (CB[7]), with a binding affinity, Ka , in the order of magnitude of 10(5)  m(-1) , thermodynamically driven by both enthalpy (ΔH=-6.79 kcal mol(-1) ) and entropy (TΔS=1.21 kcal mol(-1) ). For the first time, a dramatic inhibition of keto-enol tautomerism of the carbonyl α-hydrogen of ALA has been observed, as evidenced by over an order of magnitude decrease of both the first step rate constant, k1 , and the second step rate constant, k2 , during hydrogen/deuterium exchange in D2 O...
September 8, 2016: Chemistry, An Asian Journal
Nicholas Graves, Catherine Wloch, Jennie Wilson, Adrian Barnett, Alex Sutton, Nicola Cooper, Katharina Merollini, Victoria McCreanor, Qinglu Cheng, Edward Burn, Theresa Lamagni, Andre Charlett
BACKGROUND: A deep infection of the surgical site is reported in 0.7% of all cases of total hip arthroplasty (THA). This often leads to revision surgery that is invasive, painful and costly. A range of strategies is employed in NHS hospitals to reduce risk, yet no economic analysis has been undertaken to compare the value for money of competing prevention strategies. OBJECTIVES: To compare the costs and health benefits of strategies that reduce the risk of deep infection following THA in NHS hospitals...
July 2016: Health Technology Assessment: HTA
Katsumasa Takahashi, Kyoko Nakajima, Takaaki Murata, Masato Shino, Osamu Nikkuni, Minoru Toyoda, Yukihiro Takayasu, Kazuaki Chikamatsu
A total of 33 patients with advanced head and neck cancer (AHNC) treated with sequential chemoradiotherapy (SCRT) were retrospectively evaluated at Gunma University Hospital between 2009 and 2011. The regimen of SCRT was docetaxel, cisplatin, and fluorouracil (TPF)-based induction chemotherapy (ICT), accompanied by docetaxel and cisplatin-based concurrent chemoradiotherapy (CCRT), and oral administration of TS-1 after that. The response rate was 61%, the 3-year overall survival rate was 42%, the non-tumor-bearing survival rate was 27%, and the tumor-bearing survival rate was 15%...
May 2016: Nihon Jibiinkoka Gakkai Kaiho
Ryosuke Hara, Kazuya Yoshida, Toshiyuki Fujii, Akihiko Ikeda, Hiroshi Hashiyata, Kenbu Nakamoto, Motohiro Takeshige
The patient was a 58-year-old man with advanced gastric cancer with multiple liver metastases. He received TXL/TS-1 therapy during February 2009, but treatment was stopped immediately when he developed anorexia, diarrhea, and numbness in his fingers. Therefore, only TS-1 was administered. Following treatment initiation, tumor marker levels promptly dropped. The gastric lesion disappeared and, to date, only a slight scar remains since April 2010. Similarly, liver metastases have not been detected since August 2011...
July 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Bianca Colombo, Tommy Pepè Sciarria, Maria Reis, Barbara Scaglia, Fabrizio Adani
Two fermented cheese wheys (FCW), FCW1 composed of lactic, acetic and butyric acids in the proportion of 58/16/26 (% CODOrganic Acid (OA)) and FCW2 composed of acetic, propionic, butyric, lactic and valeric acids in the proportion of 58/19/13/6/4 (% CODOA) were used to produce polyhydroxyalkanoates (PHAs) by using a pre-selected mixed microbial culture (MMC). PHA accumulation gave for fermented FCW1 a PHA yield (Ytot) of 0.24±0.02mgCODPHAmgCODSolubleSubstrate(SS)(-1) and a total PHA production, referred to the substrate used, of 60gPHAkgcheesewheyTotalSolids(TS)(-1)...
October 2016: Bioresource Technology
Lizhi Wu, Xiujuan Deng, Shufang Zhao, Hanmei Yin, Zuoxi Zhuo, Xiangqing Fang, Yueming Liu, Mingyuan He
A facile strategy is proposed to construct a highly active oxidation catalyst with optimally distributed titanium coordination states containing "TiO4" and "TiO6" species. The "TiO6" species in TS-1(+) shows a superior catalytic oxidation activity, which is 2-3 times that of "TiO4" species in TS-1.
July 5, 2016: Chemical Communications: Chem Comm
Ngoc Thi Hong Hoang, Tetsuya Kadonosono, Takahiro Kuchimaru, Shinae Kizaka-Kondoh
Pancreatic cancer is one of the most lethal digestive system cancers with a 5-year survival rate of 4-7%. Despite extensive efforts, recent chemotherapeutic regimens have provided only limited benefits to pancreatic cancer patients. Gemcitabine and TS-1, the current standard-of-care chemotherapeutic drugs for treatment of this severe cancer, have a low response rate. Hypoxia is one of the factors contributing to treatment resistance. Specifically, overexpression of hypoxia-inducible factor, a master transcriptional regulator of cell adaption to hypoxia, is strongly correlated with poor prognosis in many human cancers...
August 2016: Cancer Science
Tetsuyuki Okubo, Masaya Kawada, Daisuke Saikawa, Kazuhiro Yamamoto, Yoshinori Suzuki, Yo Kawarada, Shuji Kitashiro, Shunichi Okushiba
A 33-year-old man underwent radical surgery for urachal cancer. Histology of the cancer revealed an adenocarcinoma of the urachus, Sheldon stage ⅢA. He developed a right lung nodule 23 months after the surgery. Partial lobectomy was performed;it revealed an adenocarcinoma compatible with urachal carcinoma. Additionally, 2 right lung metastases measuring 0.5 cm and 1.6 cm in diameter were found 12 months after partial lobectomy. The patient was treated with 4 different chemotherapy regimens including TS-1 and cisplatin, paclitaxel, folinic acid・fluorouracil・oxaliplatin(FOLFOX), and folinic acid・fluorouracil・irinotecan (FOLFIRI)...
March 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Muneyuki Koyama, Akiyoshi Kinoshita, Ken Tanaka, Kazuhiko Koike, Hirokazu Nishino
The patient was a 74-year-old man. A medical examination for diabetes revealed a hypovascular tumor in the pancreatic head. A heterogeneously enhanced tumor in the ascending colon with wall thickening was observed on enhanced CT of the abdomen. He was diagnosed with multiple primary cancers of the pancreas and colon. He received 12 courses of chemotherapy with gemcitabine (1,000 mg/m 2) and TS-1 (60 mg/m2). After 12 courses of chemotherapy, the size of the pancreatic tumor was slightly decreased and the size of the tumor in the colon was significantly decreased...
March 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Adi Setiawan, Jarrod Friggieri, Hadi Hosseiniamoli, Eric M Kennedy, Bogdan Z Dlugogorski, Adesoji A Adesina, Michael Stockenhuber
A novel Pd supported on TS-1 combustion catalyst was synthesized and tested in methane combustion under very lean and under highly humid conditions (<1%). A notable increase in hydrothermal stability was observed over 1900 h time-on-stream experiments, where an almost constant, steady state activity obtaining 90% methane conversion was achieved below 500 °C. Surface oxygen mobility and coverage plays a major role in the activity and stability of the lean methane combustion in the presence of large excess of water vapour...
April 21, 2016: Physical Chemistry Chemical Physics: PCCP
Chengli Zu, Sukrit Mukhopadhyay, Patrick S Hanley, Shijing Xia, Bruce M Bell, David Grigg, Jeffrey R Gilbert, John P O'Brien
An ion of m/z 110.06036 (ion formula [C6H8NO](+); error: 0.32 mDa) was observed in the collision induced dissociation tandem mass spectrometry experiments of protonated N-(3-aminophenyl)benzamide, which is a rearrangement product ion purportedly through nitrogen-oxygen (N-O) exchange. The N-O exchange rearrangement was confirmed by the MS/MS spectrum of protonated N-(3-aminophenyl)-O (18) -benzamide, where the rearranged ion, [C6H8NO (18) ](+) of m/z 112 was available because of the presence of O (18) . Theoretical calculations using Density Functional Theory (DFT) at B3LYP/6-31 g(d) level suggest that an ion-neutral complex containing a water molecule and a nitrilium ion was formed via a transition state (TS-1), followed by the water molecule migrating to the anilide ring, eventually leading to the formation of the rearranged ion of m/z 110...
May 2016: Journal of the American Society for Mass Spectrometry
Toshiaki Ishikawa, Hiroyuki Uetake, Kenta Murotani, Takashi Kobunai, Megumi Ishiguro, Shigeyuki Matsui, Kenichi Sugihara
BACKGROUND: The adjuvant chemotherapy trial of TS-1 for colon cancer phase III trial was designed to validate the non-inferiority of the oral fluoropyrimidine S-1 to uracil and tegafur/leucovorin as adjuvant chemotherapy for stage III colonic cancer. As a prospective biomarker study of this trial, DNA copy number was studied using formalin-fixed, paraffin-embedded specimens. MATERIALS AND METHODS: FFPE blocks were obtained from 795 patients of the 1,535 patients enrolled in the study...
March 2016: Anticancer Research
Takashi Nonoshita, Shinya Otsuka, Masaru Inagaki, Hiromi Iwagaki
A 58-year-old woman with advanced gastric cancer underwent total gastrectomy in May 2012. The histological diagnosis was poorly differentiated adenocarcinoma, cT4a (SE), pN1, cM0; fStage IIIA. Chemotherapy by S-1 was started after surgery. Six months after the operation, two metastatic nodules were noticed on the liver. Therefore, the chemotherapy was switched to S-1 plus cisplatin (CDDP) in November 2012. TS-1 (80 mg/body) was administrated from day 1 to 21 followed by 14 days rest as one course. CDDP (70 mg/body) was infused on day 1...
December 2015: Hiroshima Journal of Medical Sciences
Yuka Kono, Naoki Terada, Yasushi Takashima, Kensuke Hikami, Takuya Hida, Shuhei Goto, Takuro Sunada, Yoshiyuki Okada, Noboru Shibasaki, Hiromitsu Negoro, Takashi Kobayashi, Toshinari Yamasaki, Yoshiyuki Matsui, Takahiro Inoue, Tomomi Kamba, Osamu Ogawa
A 29-year-old woman had undergone gastrocystoplasty with Mitrofanoff appendicovesicostomy for urethral trauma at 9 years of age. Since then, she was being followed up for performing clean intermittent self-catheterization at regular intervals. Twenty years after the surgery, she presented with gross hematuria. Ultrasonographic findings revealed bilateral hydronephrosis. Cystoscopy and computed tomography (CT) revealed invasive bladder cancer with pelvic lymph node metastases. A biopsy confirmed the diagnosis of adenocarcinoma with signet ring cell carcinoma...
January 2016: Hinyokika Kiyo. Acta Urologica Japonica
Mohd Shahnawaz, Manisha K Sangale, Avinash B Ade
Polythene degradation leads to the production of various by-products depending upon the type of degradation process. The polythene degradation products (PEDP) in the culture supernatant of the two bacteria (Lysinibacillus fusiformis strain VASB14/WL and Bacillus cereus strain VASB1/TS) were analyzed with GC-MS technique. The major by-products in the PEDP in the culture supernatant of L. fusiformis strain VASB14/WL (1,2,3,4 tetra methyl benzene) and B. cereus strain VASB1/TS (1,2,3 trimethyl benzene, 1 ethyl 3,5-dimethyl benzene, 1,4 di methyl 2 ethyl benzene, and dibutyl phthalate) dissolved in diethyl ether were recorded...
June 2016: Environmental Science and Pollution Research International
Shuting Du, Fen Li, Qiming Sun, Ning Wang, Mingjun Jia, Jihong Yu
Hierarchical TS-1 zeolites with uniform intracrystalline mesopores have been successfully synthesized through the hydrothermal method by using the green and cheap surfactant Triton X-100 as the mesoporous template. The resultant materials exhibit remarkably enhanced catalytic activity in oxidative desulfurization reactions compared to the conventional TS-1 zeolite.
February 25, 2016: Chemical Communications: Chem Comm
Eriko Aotani, Tetsutaro Hamano, Akihiko Gemma, Masahiro Takeuchi, Toru Takebayashi, Kunihiko Kobayashi
PURPOSE: In the CATS (Cisplatin And TS-1) randomized trial comparing cisplatin plus either docetaxel (DP arm) or TS-1 (SP arm) in lung cancer, efficacy was found to be equivalent but the global quality of life (QOL) score was higher in the SP arm. The purpose of the current study was to identify which of the adverse events (AEs) contributed to the deterioration of QOL. METHODS: QOL and AE data from the CATS trial were used to quantitatively analyze the relationship between deterioration of QOL score and occurrence of AEs...
February 15, 2016: International Journal of Clinical Oncology
M O Soylu, I Altun, O Basaran, Y Uzun, V Dogan, G Ergun, F Akin, M Biteker
OBJECTIVE: Impairment of heart rate turbulence (HRT) and heart rate variability (HRV) are associated with poor prognosis in chronic heart failure (CHF). Although previous studies have demonstrated that patients with a left bundle branch block (LBBB) have a better outcome with cardiac resynchronization therapy (CRT), the effect of QRS morphology on HRV and HRT is not known. We aimed to evaluate the effect of QRS morphology on HRV and HRT after CRT implantation in patients with CHF. PATIENTS AND METHODS: Patients who had been implanted a CRT device with cardioversion-defibrillation feature were included to the study...
2016: European Review for Medical and Pharmacological Sciences
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