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https://www.readbyqxmd.com/read/28251899/acral-lentiginosis-associated-with-tegafur-gimeracil-oteracil-ts-1
#1
Young Joon Park, Byoung Woo Soh, Eun-So Lee
No abstract text is available yet for this article.
March 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28224562/solitary-choroidal-metastasis-from-gastric-adenocarcinoma-a-case-report
#2
Masanari Shimada, Susumu Amaya, Hiroaki Sugita, Yuichiro Furutani, Yoshinori Munemoto, Takeshi Mitsui, Toshiro Tanahashi, Yuzo Kikuchi
BACKGROUND: Metastatic choroidal carcinomas that originated from the gastrointestinal tract are extremely rare. We report a case of suspected solitary choroidal metastasis from gastric adenocarcinoma. CASE PRESENTATION: The patient was a 60-year-old man who had undergone laparoscopic distal gastrectomy with D1+ lymphadenecetomy for gastric cancer. The clinical stage was T1bN0M0 (TNM classification), but the pathological stage was T4aN0M0 beyond expectation. Adjuvant chemotherapy with oral Tegafur, Gimeracil, Oteracil potassium (TS-1(®)) was initiated...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28222207/impact-of-the-type-of-dialysis-membranes-on-the-circulating-concentration-of-markers-of-vitamin-d-metabolism
#3
Etienne Cavalier, Pablo U Torres, Bernard E Dubois, Nicole Smelten, Hans Pottel, Jean-Marie Krzesinski, Pierre Delanaye
INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to-patient inconsistency can be observed in response to the treatment. In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage. MATERIAL AND METHODS: Alb (Cobas), VDBP (R&D) and 25(OH)D (liquid chromatography-tandem mass spectrometry) were measured in 75 patients before and after a 4-hour dialysis session...
February 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28133332/-multidisciplinary-treatment-for-high-risk-gist-of-the-stomach
#4
Tomo Ishida, Shigeyuki Tamura, Atsushi Takeno, Kohei Murakami, Yohei Nose, Ryota Mori, Yasuo Oneda, Ryuichi Kuwahara, Takuya Sakamoto, Atsushi Naito, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Yutaka Takeda, Takeshi Kato
A 59-year-old man underwent total gastrectomy(with D2 dissection)and cholecystectomy for gastric cancer and a submucosal tumor of the stomach. The specimen was immunohistochemically positive for c-kit, the Ki-67 label index was 10%, and the mitotic count was 20/HPF. Finally, the patient was diagnosed with high-risk gastrointestinal stromal cancer with normal type gastric cancer. After discharge from hospital, we started administration of TS-1 as adjuvant therapy for the gastric cancer. As multiple recurrences of the GIST in the abdomen developed, the patient underwent 3 radical local resections...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133325/-a-patient-with-stage-iv-gastric-cancer-who-survived-more-than-five-years-after-gastrectomy
#5
Ayumi Takaoka, Shinsuke Usui, Yuuichi Kumaki, Tomohiro Akutsu, Hiroko Matsunaga, Masaki Tashiro, Kaida Arita, Shigeo Haruki, Koji Ito, Akiyo Matsumoto, Noriaki Takiguchi
The prognosis of patients with Stage IV gastric cancer is generally poor. The 5-year overall survival rate is less than 10%. The patient was a 73-year-old man with Stage IV gastric cancer. Before chemotherapy, peritoneal dissemination was observed using staging laparoscopy. The patient received first-line chemotherapy with TS-1 plus CDDP. Renal function worsened and consequently the therapy was stopped. He received 3 courses of chemotherapy with weekly PTX. The peritoneal dissemination had disappeared by the second staging laparoscopy and he underwent distal gastrectomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133302/-two-cases-of-locally-recurrent-rectal-cancer-after-intersphincteric-resection-that-were-controlled-with-a-combination-of-chemoradiotherapy-and-abdominoperineal-resection
#6
Yasuhiro Komatsu, Hitoshi Idani, Kazutaka Takahashi, Naoki Mimura, Toshihiro Ogawa, Soichiro Miyake, Michihiro Ishida, Daisuke Satoh, Yasuhiro Choda, Daisuke Sumitani, Masao Harano, Hiroyoshi Matsukawa, Yasutomo Ojima, Shigehiro Shiozaki, Masazumi Okajima
We report 2 cases of locally recurrent rectal cancer after intersphincteric resection(ISR)that were controlled with a combination of chemoradiotherapy and abdominoperineal resection(APR). In Case 1, we performed preoperative chemoradiotherapy( TS-1 plus RT 45 Gy)and APR for the local recurrence of ISR. On pathology, viable neoplastic cells were noted. In Case 2, we performed preoperative chemotherapy(Bmab plus mFOLFOX6)and APR for the local recurrence of ISR. On pathology, no viable neoplastic cells were noted...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133167/-a-case-of-t1a-early-gastric-cancer-that-metastasized-to-the-right-femoral-muscles-six-years-and-seven-months-after-radical-surgery
#7
Chikara Ebisui, Rie Hamano, Yoichiro Nushijima, Tetsu Yanagisawa, Shu Okamura, Nariaki Fukuchi, Kohei Murata, Hideoki Yokouchi, Masakatsu Kinuta, Kazuhito Ohishi
A 49-year-old woman presented to our hospital complaining of abdominal distension and right thigh edema 6 years and 7 months after undergoing total gastrectomy for early gastric cancer in December 2008. The histopathological type of the tumor was poorly differentiated adenocarcinoma. The pathological findings led to a diagnosis of T1aN2M0, Stage II A disease. In August 2015, abdominal CT and MRI revealed para-aortic lymph node swelling, ascites, and a tumor on the right femoral muscles. We performed a needle biopsy of the femoral muscle, and the final diagnosis was intramuscular metastasis from the primary gastric cancer...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133106/-treatment-outcome-of-anal-squamous-cell-carcinoma-treated-with-radical-chemoradiotherapy
#8
Harunobu Sato, Yoshikazu Koide, Miho Shiota, Zenichi Morise, Koutarou Maeda, Ichiro Uyama
We reviewed the clinical records of 7 patients with anal squamous cell carcinoma(SCC)to evaluate the effectiveness of radical chemoradiotherapy(CRT). The radiotherapy(RT)consisted of 40 Gy delivered to the pelvis and bilateral inguinal lesions, and a perianal booster dose of 20 Gy, in fractions of 2.0 Gy per day, 5 days per week. 5-fluorouracil(5-FU)and mitomycin C(MMC)were administered 3 times every 4weeks as standard chemotherapy. On the first day of RT, 750mg/m2 of 5-FU in the form of a continuous 24-hour infusion, for 5 days was administered...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133094/-experience-with-gemcitabine-plus-nab-paclitaxel-therapy-for-advanced-metastatic-pancreatic-cancer-in-our-hospital
#9
Shigeta Hagino, Akira Nakayama, Koya Sakamoto
A 71-year-old-man was referred to our hospital because of jaundice of the skin. On biochemical examination of blood, we identified an elevation in the levels of AST and ALT, the serum level of biliary enzymes, and the serum levels of tumor markers. We found pancreatic head cancer with invasion to the main blood vessels and duodenum, with liver metastases, on abdominal CT. We made a diagnosis of unresectable advanced pancreatic head cancer with distant metastasis, and we initiated gemcitabine plus nab-paclitaxel therapy as first-line chemotherapy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133087/-a-case-of-carcinoma-associated-with-an-anal-fistula-repaired-using-a-hatchet-flap-after-neoadjuvant-chemoradiotherapy
#10
Masatoshi Kuroda, Eiji Ikeda, Nobuji Yokoyama, Masaichi Kenmotsu, Shoji Takagi, Toshihisa Yamano
The patient was a 53-year-old man who complained of perianal pain. He had a 20-year history of an anal fistula. There was a 10 cm tumor with mucin-like discharge on the left side of the anus. His CEA level was high, at 7.3 ng/mL, and T2-weighted MRI revealed a multilocular cystic tumor with high signal intensity. The second biopsy result indicated mucinous adenocarcinoma. We performed neoadjuvant chemoradiotherapy. The chemotherapy regimen was TS-1 with radiation therapy, along with 4-port irradiation(50.4 Gy)of the primary tumor, located at the interior of the pelvis and inguinal lymph nodes...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133070/-a-case-of-surgical-resection-for-gallbladder-cancer-with-para-aortic-lymph-node-metastasis-following-neoadjuvant-chemotherapy-with-gemcitabine-cisplatin-and-ts-1
#11
Satoshi Nagaoka, Daisaku Yamada, Hidetoshi Eguchi, Takehiro Noda, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Koji Umeshita, Yuichiro Doki, Masaki Mori
A 60-year-old woman who visited a doctor during postoperative follow-up for breast cancer was found to have elevated CEA levels. Investigation with FDG-PET CT following enhanced CT suggested gallbladder cancer(GBC)accompanied with para-aortic lymph node(PAL)metastasis. Although we could not obtain any histological evidence, we recommended she be treated as a patient with advanced GBC, and she received 8 courses of chemotherapy consisting of gemcitabine, cisplatin, and TS-1, following the protocol of a clinical trial...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27987181/association-of-snps-in-dopamine-and-serotonin-pathway-genes-and-their-interacting-genes-with-temperament-traits-in-charolais-cows
#12
E Garza-Brenner, A M Sifuentes-Rincón, R D Randel, F A Paredes-Sánchez, G M Parra-Bracamonte, W Arellano Vera, F A Rodríguez Almeida, A Segura Cabrera
Cattle temperament is a complex trait, and molecular studies aimed at defining this trait are scarce. We used an interaction networks approach to identify new genes (interacting genes) and to estimate their effects and those of 19 dopamine- and serotonin-related genes on the temperament traits of Charolais cattle. The genes proopiomelanocortin (POMC), neuropeptide Y (NPY), solute carrier family 18, member 2 (SLC18A2) and FBJ murine osteosarcoma viral oncogene homologue (FOSFBJ) were identified as new candidates...
December 16, 2016: Journal of Applied Genetics
https://www.readbyqxmd.com/read/27814950/characteristics-of-dissolved-organic-matter-formed-in-aerobic-and-anaerobic-digestion-of-excess-activated-sludge
#13
Haixia Du, Fusheng Li
The characteristics of dissolved organic matter (DOM) formed in aerobic and anaerobic digestion of excess activated sludge (EAS) was investigated for three total solid (TS) concentrations (1.2, 2.3 and 5.2%) and three temperatures (5, 20 and 35 °C). The results on the overall concentration of DOM evaluated by TOC showed significantly higher values in anaerobic than aerobic digestion (2.8-6.9 times for TS 1.2-5.2% at 20 °C). Data analysis with a first-order sequential reaction model revealed that higher occurrence of DOM in anaerobic digestion was a result of comparatively faster hydrolysis (1...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27790371/total-or-partial-vertebrectomy-for-lung-cancer-invading-the-spine
#14
Soichi Oka, Hiroki Matsumiya, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Sohsuke Yamada, Hidetaka Uramoto, Eiichiro Nakamura, Fumihiro Tanaka
BACKGROUND: Surgery for lung cancer invading the spine remains challenging associated with high morbidity and mortality. However, recent advances in surgical techniques as well as in perioperative care may improve outcomes of lung cancer surgery with vertebrectomy. We describe our surgical approach and assess the outcome lung cancer invading the spine. METHODS: We retrospectively reviewed our recent experiences of lung cancer with vertebral invasion, in which we have performed total or partial vertebrectomy from January 2011 through April 2015...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27738871/targeting-sumo-1ylation-contrasts-synaptic-dysfunction-in-a-mouse-model-of-alzheimer-s-disease
#15
Serena Marcelli, Elena Ficulle, Filomena Iannuzzi, Enikö Kövari, Robert Nisticò, Marco Feligioni
Synaptic dysfunction has been recognized as an early feature occurring at the onset of Alzheimer's disease (AD). Compromised neurotransmission leads over time to synaptic loss and these events correlate with the cognitive decline that progressively affects AD patients.Protein SUMOylation (Small Ubiquitin-like MOdifier) is a post-translational modification (PTM) involved in several cellular processes including synaptic transmission.We here demonstrate that cortical synaptosomes prepared from Tg2576 mice of 6 months of age show an increased SUMO-1ylation, which returns back to normal levels at 20 months although synaptic SUMOylation, at this age, resulted more sensible to KCl stimulus...
October 13, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27678432/a-3-year-study-of-atorvastatin-in-children-and-adolescents-with-heterozygous-familial-hypercholesterolemia
#16
Gisle Langslet, Andrei Breazna, Euridiki Drogari
BACKGROUND: The efficacy and safety of atorvastatin in children/adolescents aged 10-17 years with heterozygous familial hypercholesterolemia (HeFH) have been demonstrated in trials of up to 1 year in duration. However, the efficacy/safety of >1 year use of atorvastatin in children/adolescents with HeFH, including children from 6 years of age, has not been assessed. OBJECTIVE: To characterize the efficacy and safety of atorvastatin over 3 years and to assess the impact on growth and development in children aged 6-15 years with HeFH...
September 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27605465/encapsulation-of-age-breaker-alagebrium-by-cucurbit-7-uril-improved-the-stability-of-both-its-carbonyl-%C3%AE-hydrogen-and-thiazolium-c2-hydrogen
#17
Shengke Li, Yuan-Fu Ding, Hang Yin, Chunming Wang, David Bardelang, Lian-Hui Wang, Ruibing Wang
As determined by both (1) H NMR and UV/Vis spectroscopic titration, ESI-MS, isothermal titration calorimetry, and DFT molecular modeling, advanced glycation end products (AGE) breaker alagebrium (ALA) formed 1:1 guest-host inclusion complexes with cucurbit[7]uril (CB[7]), with a binding affinity, Ka , in the order of magnitude of 10(5)  m(-1) , thermodynamically driven by both enthalpy (ΔH=-6.79 kcal mol(-1) ) and entropy (TΔS=1.21 kcal mol(-1) ). For the first time, a dramatic inhibition of keto-enol tautomerism of the carbonyl α-hydrogen of ALA has been observed, as evidenced by over an order of magnitude decrease of both the first step rate constant, k1 , and the second step rate constant, k2 , during hydrogen/deuterium exchange in D2 O...
November 7, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27468732/a-cost-effectiveness-modelling-study-of-strategies-to-reduce-risk-of-infection-following-primary-hip-replacement-based-on-a-systematic-review
#18
Nicholas Graves, Catherine Wloch, Jennie Wilson, Adrian Barnett, Alex Sutton, Nicola Cooper, Katharina Merollini, Victoria McCreanor, Qinglu Cheng, Edward Burn, Theresa Lamagni, Andre Charlett
BACKGROUND: A deep infection of the surgical site is reported in 0.7% of all cases of total hip arthroplasty (THA). This often leads to revision surgery that is invasive, painful and costly. A range of strategies is employed in NHS hospitals to reduce risk, yet no economic analysis has been undertaken to compare the value for money of competing prevention strategies. OBJECTIVES: To compare the costs and health benefits of strategies that reduce the risk of deep infection following THA in NHS hospitals...
July 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27459819/-sequential-chemoradiotherapy-for-advanced-head-and-neck-cancer-a-clinical-study-with-33-cases
#19
Katsumasa Takahashi, Kyoko Nakajima, Takaaki Murata, Masato Shino, Osamu Nikkuni, Minoru Toyoda, Yukihiro Takayasu, Kazuaki Chikamatsu
A total of 33 patients with advanced head and neck cancer (AHNC) treated with sequential chemoradiotherapy (SCRT) were retrospectively evaluated at Gunma University Hospital between 2009 and 2011. The regimen of SCRT was docetaxel, cisplatin, and fluorouracil (TPF)-based induction chemotherapy (ICT), accompanied by docetaxel and cisplatin-based concurrent chemoradiotherapy (CCRT), and oral administration of TS-1 after that. The response rate was 61%, the 3-year overall survival rate was 42%, the non-tumor-bearing survival rate was 27%, and the tumor-bearing survival rate was 15%...
May 2016: Nihon Jibiinkoka Gakkai Kaiho
https://www.readbyqxmd.com/read/27431636/-a-patient-with-stage-iv-advanced-gastric-cancer-with-multiple-liver-metastases-living-for-more-than-6-years-after-treatment-with-ts-1-alone
#20
Ryosuke Hara, Kazuya Yoshida, Toshiyuki Fujii, Akihiko Ikeda, Hiroshi Hashiyata, Kenbu Nakamoto, Motohiro Takeshige
The patient was a 58-year-old man with advanced gastric cancer with multiple liver metastases. He received TXL/TS-1 therapy during February 2009, but treatment was stopped immediately when he developed anorexia, diarrhea, and numbness in his fingers. Therefore, only TS-1 was administered. Following treatment initiation, tumor marker levels promptly dropped. The gastric lesion disappeared and, to date, only a slight scar remains since April 2010. Similarly, liver metastases have not been detected since August 2011...
July 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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