Isabel Rodriguez, Nicole M Rossi, Ayse Keskus, Yi Xie, Tanveer Ahmad, Asher Bryant, Hong Lou, Jesica Godinez Paredes, Rose Milano, Nina Rao, Sonam Tulsyan, Joseph F Boland, Wen Luo, Jia Liu, Tim O'Hanlon, Jazmyn Bess, Vera Mukhina, Daria Gaykalova, Yuko Yuki, Laksh Malik, Kimberley Billingsley, Cornelis Blauwendraat, Mary Carrington, Meredith Yeager, Lisa Mirabello, Mikhail Kolmogorov, Michael Dean
Cervical cancer is caused by human papillomavirus (HPV) infection, has few approved targeted therapeutics, and is the most common cause of cancer death in low-resource countries. We characterized 19 cervical and four head and neck cell lines using long-read DNA and RNA sequencing and identified the HPV types, HPV integration sites, chromosomal alterations, and cancer driver mutations. Structural variation analysis revealed telomeric deletions associated with DNA inversions resulting from breakage-fusion-bridge (BFB) cycles...
August 22, 2023: medRxiv