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https://www.readbyqxmd.com/read/29166350/competency-crosswalk-a-multispecialty-review-of-the-accreditation-council-for-graduate-medical-education-milestones-across-four-competency-domains
#1
Laura Edgar, Sydney Roberts, Nicholas Yaghmour, Andrea Leep Hunderfund, Stanley J Hamstra, Lisa Conforti, Eric S Holmboe
PURPOSE: To identify common and overlapping themes among the interpersonal and communication skills (ICS), practice-based learning and improvement (PBLI), professionalism (PROF), and systems-based practice (SBP) milestones of the transitional year and 26 specialties. METHOD: In May 2017, milestones were accessed from the Accreditation Council for Graduate Medical Education specialties website. A thematic analysis of the ICS, PBLI, PROF, and SBP milestones was performed to determine unique and common themes across these competencies and across specialties...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29164797/impact-of-systolic-blood-pressure-on-the-safety-and-tolerability-of-initiating-and-up-titrating-sacubitril-valsartan-in-patients-with-heart-failure-and-reduced-ejection-fraction-insights-from-the-titration-study
#2
Michele Senni, John J V McMurray, Rolf Wachter, Hugh F McIntyre, Inder S Anand, Vincenzo Duino, Arnab Sarkar, Victor Shi, Alan Charney
AIMS: The TITRATION trial investigated two strategies to initiate and up-titrate sacubitril/valsartan (LCZ696) to the same target dose, over a condensed (3-week) or conservative (6-week) period, in patients with heart failure with reduced ejection fraction (HFrEF) and systolic blood pressure (SBP) of ≥100 mmHg. This post hoc analysis examined the relationship between baseline SBP at screening and achievement of the target dose of sacubitril/valsartan of 97 mg/103 mg (also termed 'LCZ696 200 mg') twice per day during the study...
November 22, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29164516/mineralocorticoid-receptor-antagonism-protects-the-aorta-from-vascular-smooth-muscle-cell-proliferation-and-collagen-deposition-in-a-rat-model-of-adrenal-aldosterone-producing-adenoma
#3
Yongji Yan, Chao Wang, Yiqin Lu, Huijie Gong, Zhun Wu, Xin Ma, Hongzhao Li, Baojun Wang, Xu Zhang
The number of patients with adrenal aldosterone-producing adenomas (APAs) has gradually increased. However, even after adenoma resection, some patients still suffer from high systolic blood pressure (SBP), which is possibly due to great arterial remodeling. Moreover, mineralocorticoid receptors (MRs) were found to be expressed in vascular smooth muscle cells (VSMCs). This study aims to determine whether MR antagonism protects the aorta from aldosterone-induced aortic remolding. Male rats were subcutaneously implanted with an osmotic minipumps and randomly divided into four groups: control; aldosterone (1 μg/h); aldosterone plus a specific MR antagonist, eplerenone (100 mg/kg/day); and aldosterone plus a vasodilator, hydralazine (25 mg/kg/day)...
November 21, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29164391/association-between-low-diastolic-blood-pressure-and-subclinical-myocardial-injury
#4
George S Waits, Wesley T O'Neal, Pratik B Sandesara, Yabing Li, Amit J Shah, Elsayed Z Soliman
BACKGROUND: Coronary arteries perfuse cardiac myocytes during diastole. We hypothesized that marked lowering of diastolic blood pressure (DBP) is associated with increased risk of subclinical myocardial injury (SC-MI). METHODS: This analysis included 6107 participants without history of cardiovascular disease (CVD) from the third National Health and Nutrition Examination Survey. SC-MI was determined by a validated electrocardiogram-based scoring system. Logistic regression was used to examine the cross-sectional association between DBP (< 70, 70-80 mmHg (reference group), and > 80 mmHg; and per each 10 mmHg decrease, separately) with SC-MI across levels of systolic blood pressure (SBP) (< 120, 120-139, or > 140 mmHg)...
November 21, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29161063/impact-of-the-2010-us-healthy-hunger-free-kids-act-on-school-breakfast-and-lunch-participation-rates-between-2008-and-2015
#5
Nicole Vaudrin, Kristen Lloyd, Michael J Yedidia, Michael Todd, Punam Ohri-Vachaspati
OBJECTIVES: To evaluate National School Lunch Program (NSLP) and School Breakfast Program (SBP) participation over a 7-year period before and after the implementation of the 2010 Healthy, Hunger-Free Kids Act (HHFKA), which required healthier school lunch options beginning in school year (SY) 2012-2013 and healthier school breakfast options beginning in SY2013-2014. METHODS: Data were gathered from low-income, high-minority public schools in 4 New Jersey cities...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29158982/genome-wide-in-silico-identification-of-membrane-bound-transcription-factors-in-plant-species
#6
Shixiang Yao, Lili Deng, Kaifang Zeng
Membrane-bound transcription factors (MTFs) are located in cellular membranes due to their transmembrane domains. In plants, proteolytic processing is considered to be the main mechanism for MTF activation, which ensures the liberation of MTFs from membranes and further their translocation into the nucleus to regulate gene expression; this process skips both the transcriptional and translational stages, and thus it guarantees the prompt responses of plants to various stimuli. Currently, information concerning plant MTFs is limited to model organisms, including Arabidopsis thaliana and Oryza sativa, and little is known in other plant species at the genome level...
2017: PeerJ
https://www.readbyqxmd.com/read/29158710/the-impact-of-pharmacists-providing-direct-patient-care-as-members-of-interprofessional-teams-on-diabetes-management
#7
Osamah M Alfayez, Majed S Al Yami, Maryam T Fazel
The purpose of this study was to evaluate the impact of pharmacist providing direct patient care as a member of interprofessional team on diabetes management. This study is a retrospective chart review of diabetes patients seen by a pharmacist in an endocrinology clinic affiliated with an academic medical center. The following patient outcomes were recorded pre and post the pharmacist intervention: glycemic control as measured by change in hemoglobin A1c (HbA1c), change in systolic blood pressure (SBP) and diastolic blood pressure (DBP), statin use, and use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs)...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29158677/a-meta-analysis-of-effects-of-selective-serotonin-reuptake-inhibitors-on-blood-pressure-in-depression-treatment-outcomes-from-placebo-and-serotonin-and-noradrenaline-reuptake-inhibitor-controlled-trials
#8
REVIEW
Zhuoyuan Zhong, Limin Wang, Xiaojun Wen, Yunyun Liu, Yafei Fan, Zhonglin Liu
Background: Selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) have been commonly prescribed for depression treatment. However, their effects on blood pressure are unclear. Materials and methods: Effects on blood pressure of depressive patients in two groups (SSRIs versus placebo and SSRIs versus SNRIs) were evaluated. A search was conducted for double-blind, randomized controlled trials (RCTs) in PubMed, EMBASE, ISI Web of Science, PsycNET, CCRCT, and DARE (up to March 2017)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29158613/blood-pressure-heart-rate-and-perceived-enjoyment-after-small-sided-soccer-games-and-repeated-sprint-in-untrained-healthy-adolescents
#9
Amri Hammami, Sofien Kasmi, Paulo Farinatti, Taieb Fgiri, Karim Chamari, Ezdine Bouhlel
The purpose of this study was to examine systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), rating of perceived exertion (RPE) and perceived enjoyment responses to a repeated-sprint training session (RST) compared to a small-sided soccer game session (SSG) in untrained adolescents. Twelve healthy post-pubertal adolescent males (age 15.8±0.6 years, body mass 59.1±3.7 kg, height 1.7±0.1m) performed RST and SSG sessions in a randomized and counterbalanced order. Blood pressure and HR were measured at rest and at 10, 20 and 30 minutes after interventions, and RPE and enjoyment were assessed...
September 2017: Biology of Sport
https://www.readbyqxmd.com/read/29156835/indonesian-herbal-medicine-prevents-hypertension-induced-left-ventricular-hypertrophy-by-diminishing-nadph-oxidase-dependent-oxidative-stress
#10
Erna Sulistyowati, Jong-Hau Hsu, Yuan-Bin Cheng, Fang-Rong Chang, Ying-Fu Chen, Jwu-Lai Yeh
Indonesian herbal medicine Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced left ventricular hypertrophy (H-LVH). This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stress-related cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4. Forty-weeks-old SHRs and normotensive-WKY rats, were both randomly divided into 2 groups: CJID and control...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156411/relationship-between-carotid-artery-sclerosis-and-blood-pressure-variability-in-essential-hypertension-patients
#11
Xianglin Chi, Min Li, Xia Zhan, Honghao Man, Shunliang Xu, Dingchang Zheng, Jianzhong Bi, Yingcui Wang, Chengyu Liu
OBJECTIVES: This study aimed to investigate the relationship between the presence of carotid arteriosclerosis (CAS) and blood pressure variability (BPV) in patients with essential hypertension. METHODS: One hundred and forty four essential hypertension patients underwent ambulatory BP monitoring for 24h after hospitalization. Common BPV metrics were calculated. General clinical parameters, including age, gender, height, weight, history of coronary heart disease, stroke, diabetes, hypertension, smoking and drink, were recorded...
March 18, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29156004/obesity-modulates-the-association-between-systolic-blood-pressure-and-albuminuria
#12
James Fotheringham, Bisher Kawar, William McKane, Timothy Ellam
Background: Obesity is associated with albuminuria and incident kidney disease. Increased vulnerability of the glomerular microcirculation to elevated systemic blood pressure is postulated to contribute to adverse effects of obesity on the kidney. We therefore hypothesized that obesity would modulate the association between systolic blood pressure (sBP) and albuminuria. Methods: The relationship between obesity and albuminuria [fractional albumin excretion (FE alb ) or albumin:creatinine ratio (ACR)] was modelled using linear/logistic regression in the US National Health and Nutrition Examination Survey 1999-2010 cohorts ( N  = 23 710)...
May 30, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29155883/admixture-mapping-in-the-hispanic-community-health-study-study-of-latinos-reveals-regions-of-genetic-associations-with-blood-pressure-traits
#13
Tamar Sofer, Leslie J Baier, Sharon R Browning, Timothy A Thornton, Gregory A Talavera, Sylvia Wassertheil-Smoller, Martha L Daviglus, Robert Hanson, Sayuko Kobes, Richard S Cooper, Jianwen Cai, Daniel Levy, Alex P Reiner, Nora Franceschini
Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local ancestry allele counts and the trait of interest. We performed admixture mapping of the blood pressure traits systolic and diastolic blood pressure (SBP, DBP), mean arterial pressure (MAP), and pulse pressure (PP), in a dataset of 12,116 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos have three predominant ancestral populations (European, African, and Amerindian), for each of which we separately tested local ancestry intervals across the genome...
2017: PloS One
https://www.readbyqxmd.com/read/29154726/comparison-of-apolipoprotein-apob-apoa-1-and-lipoprotein-total-cholesterol-hdl-ratios-in-obese-adolescents
#14
Ramin Alemzadeh, Jessica Kichler
BACKGROUND: Serum (ApoB/ApoA-1) ratio is considered a stronger predictor of systemic inflammation and atherosclerosis than serum total cholesterol/HDL (TC/HDL) ratio among adults. We evaluated the relationships between ApoB/ApoA-1 and TC/HDL ratios with surrogate markers of inflammation and insulin resistance (IR) among obese adolescents. METHODS: Body mass index z-score (BMI-z), body composition, fasting glucose, insulin, lipids, high-sensitive c-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 143 obese adolescents...
November 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29153856/the-effect-of-viscous-soluble-fiber-on-blood-pressure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
K Khan, E Jovanovski, H V T Ho, A C R Marques, A Zurbau, S B Mejia, J L Sievenpiper, V Vuksan
AIMS: Dietary fiber intake, especially viscous soluble fiber, has been established as a means to reduce cardiometabolic risk factors. Whether this is true for blood pressure remains controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the effects of viscous soluble fiber supplementation on blood pressure and quantify the effect of individual fibers. DATA SYNTHESIS: MEDLINE, Embase, and Cochrane databases were searched...
October 7, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29153692/effects-of-postpartum-uterine-curettage-in-the-recovery-from-preeclampsia-eclampsia-a-randomized-controlled-trial
#16
Gamaliel Mc Lean, Osvaldo Reyes, Rodrigo Velarde
OBJECTIVE: To evaluate if postpartum uterine curettage improved the clinical and laboratory parameters in patients with preeclampsia or eclampsia. METHODS: A total of 442 patients with preeclampsia/eclampsia were randomized to postpartum curettage (223) or no procedure (219). Systolic and diastolic blood pressure were recorded and analyzed at hours 6, 12, 24 and 48. Also, several laboratory values and diuresis were evaluated. RESULTS: No statistical differences were found between groups (curettage vs...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153682/home-blood-pressure-measurement-in-women-with-pregnancy-related-hypertensive-disorders
#17
Patrick G Lan, Jon Hyett, Adrian G Gillin
OBJECTIVES: To determine if home blood pressure measurement (HBPM) provides comparable results to clinic blood pressure (BP) measurement. STUDY DESIGN: A prospective, single-centre study of 37 pregnant and early post-partum women with a hypertensive pregnancy or at high-risk of developing a hypertensive pregnancy were asked to perform HBPM for a minimum period of one week. This was subsequently compared to clinic BP measurement both before and after the period of home measurement...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153113/a-systematic-review-of-economic-evidence-on-community-hypertension-interventions
#18
REVIEW
Donglan Zhang, Guijing Wang, Heesoo Joo
CONTEXT: Effective community-based interventions are available to control hypertension. It is important to determine the economics of these interventions. EVIDENCE ACQUISITION: Peer-reviewed studies from January 1995 through December 2015 were screened. Interventions were categorized into educational interventions, self-monitoring interventions, and screening interventions. Incremental cost-effectiveness ratios were summarized by types of interventions. The review was conducted in 2016...
December 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29151830/antihypertensive-properties-of-tilapia-oreochromis-spp-frame-and-skin-enzymatic-protein-hydrolysates
#19
Hsin-Chieh Lin, Adeola M Alashi, Rotimi E Aluko, Bonnie Sun Pan, Yu-Wei Chang
Proteins from tilapia frame and skin can potentially be precursors of antihypertensive peptides according to the result of BIOPEP analyses. The aim was to generate peptides with inhibitory effects against angiotensin-converting enzyme (ACE) and renin from tilapia frame and skin protein isolates (FPI and SPI). The most active hydrolysate was then tested for blood pressure-lowering ability in spontaneously hypertensive rats (SHRs). Tilapia frame and skin protein hydrolysates (FPHs and SPHs) were respectively produced from FPI and SPI hydrolysis using pepsin, papain, or bromelain...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29151530/successful-autologous-hematopoietic-stem-cell-transplantation-followed-by-bortezomib-maintenance-in-a-patient-with-relapsed-cd138-low-multiple-solitary-plasmacytomas-harboring-a-17p-deletion
#20
Hiroaki Kitamura, Yasushi Kubota, Kyosuke Yamaguchi, Kazuharu Kamachi, Atsujiro Nishioka, Masako Yokoo, Takero Shindo, Toshihiko Ando, Kensuke Kojima, Shinya Kimura
Solitary plasmacytoma of bone (SBP) tends to progress to multiple myeloma (MM); however, progression to multiple solitary plasmacytomas (MSP) is rare. We report a case of CD138-low MSP with 17p deletion in a patient with relapsed SBP. 17p deletion is associated with a poor outcome in patients with MM, and the low expression of CD138 in myeloma cells is associated with drug resistance and a poor prognosis. The patient was successfully treated with bortezomib plus dexamethasone induction therapy and autologous hematopoietic stem cell transplantation followed by bortezomib maintenance therapy...
November 20, 2017: Internal Medicine
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