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https://www.readbyqxmd.com/read/28938338/mortality-implications-of-lower-dbp-with-lower-achieved-systolic-pressures-in-coronary-artery-disease-long-term-mortality-results-from-the-international-verapamil-trandolapril-study-us-cohort
#1
Anita Wokhlu, Steven M Smith, Yan Gong, Eileen M Handberg, Islam Y Elgendy, Anthony A Bavry, Rhonda M Cooper-DeHoff, Carl J Pepine
OBJECTIVES: A goal SBP 120 mmHg or less reduced mortality in high-risk Systolic Blood Pressure Intervention Trial patients; however, mortality implications of concomitant DBP lowering in coronary artery disease (CAD) are uncertain. We examined the relationship between DBP lowering and all-cause mortality with lower achieved SBPs in a large cohort. METHODS: We categorized 17 131 hypertensive patients from the INternational VErapamil-trandolapril STudy US cohort, aged at least 50 years with CAD, by mean achieved SBP (<120, 120 to <130, 130 to <140, and ≥140 mmHg) and DBP tertiles (low, middle, and high per SBP category) during active follow-up...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28936268/mildly-elevated-serum-total-bilirubin-is-negatively-associated-with-hemoglobin-a1c-independently-of-confounding-factors-among-community-dwelling-middle-aged-and-elderly-persons
#2
Ryuichi Kawamoto, Daisuke Ninomiya, Kensuke Senzaki, Teru Kumagi
Abnormally high glycated hemoglobin (Hb) (HbA1c) is significantly associated with oxidative stress and an increased risk of cardiovascular disease (CVD). Serum total bilirubin (T-B) may have a beneficial role in preventing oxidative changes and be a negative risk factor of CVD. Limited information is available on whether serum T-B is an independent confounding factor of HbA1c. The study subjects were 633 men aged 70 ± 9 (mean ± standard deviation (SD)) years and 878 women aged 70 ± 8 years who were enrolled consecutively from among patients aged ≥40 years through a community-based annual check-up process...
January 2017: J Circ Biomark
https://www.readbyqxmd.com/read/28935762/effect-of-different-anesthetic-methods-on-cellular-immune-functioning-and-the-prognosis-of-patients-with-ovarian-cancer-undergoing-oophorectomy
#3
Xin-Rui Han, Xin Wen, Yan-Yi Li, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Xing-Feng Sun, Gui-Qi Geng, Shen Sun, Shao-Qiang Huang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aimed to explore the effects of different anesthetic methods on cellular immune function and prognosis of patients with ovarian cancer (OC) undergoing oophorectomy. A total of 167 patients who received general anesthesia (GA) treatment (GA group) and 154 patients who received combined general/epidural anesthesia (GEA) treatment (GEA group) were collected retrospectively. Each group selected 124 patients that met the inclusion and exclusion criteria for further study. ELISA and radioimmunoassay were employed to detect levels of IL-2, TNF-α and CA-125...
September 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28933578/effects-of-resveratrol-supplementation-on-risk-factors-of-non-communicable-diseases-a-meta-analysis-of-randomized-controlled-trials
#4
Xiao-Fei Guo, Jiao-Mei Li, Jun Tang, Duo Li
The results of randomized controlled trials (RCTs) investigating resveratrol supplementation on risk factors of non-communicable diseases (NCDs) have been inconsistent. The present meta-analysis aimed to quantitatively evaluate the effects of resveratrol intervention on risk factors of NCDs. PubMed and Scopus databases were searched up to June 2017. Weighted mean differences were calculated for net changes in risk factors of NCDs by using a random-effects model. Pre-specified subgroup and univariate meta-regression analyses were carried out to explore the sources of heterogeneity...
September 21, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28932498/hemodynamic-effect-of-intravenous-lidocaine-during-aortic-cannulation-in-cardiac-surgery
#5
Ziya Totonchi, Shirin Salajegheh, Mahmoud Reza Mohaghegh, Mehrdad Mesbah Kiaei, Mohammad Shirvani, Masoud Ghorbanlo
BACKGROUND: Dissection of aorta is a rare, but fatal complication of aortic cannulation in cardiac surgery can be caused by the sudden rise in blood pressure and hemodynamic variations. METHODS: In this study, 90 patients aged 18 years or older undergoing cardiac surgery were divided into two equal groups. Under similar conditions, trial group received 1.5 mg/kg of lidocaine for 90 s before cannulation and control group received normal saline. Hemodynamic parameters of patients including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and central venous pressure before cannulation and 1, 3, and 5 min after cannulation were recorded in a form...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28932292/methotrexate-blood-pressure-and-markers-of-arterial-function-in-patients-with-rheumatoid-arthritis-a-repeated-cross-sectional-study
#6
Arduino A Mangoni, Leena R Baghdadi, E Michael Shanahan, Michael D Wiese, Sara Tommasi, David Elliot, Richard J Woodman
BACKGROUND: Methotrexate (MTX) treatment in rheumatoid arthritis (RA) has been associated with lower cardiovascular risk compared to other disease-modifying antirheumatic drugs (DMARDs). We sought to identify whether the MTX-associated cardioprotection involves changes in blood pressure (BP) and/or arterial function. METHODS: Clinic and 24-hour peripheral and central systolic and diastolic BP (SBP and DBP), augmentation index (AIx), pulse wave velocity (PWV) and plasma asymmetric dimethylarginine (ADMA) were assessed in RA patients on stable treatment with either MTX ± other DMARDs (MTX group, n = 56, age 61 ± 13 years, 70% females) or other DMARDs (non-MTX group, n = 30, age 63 ± 12 years, 76% females)...
September 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28930947/the-mortality-ascent-hourly-risk-of-death-for-hemodynamically-unstable-trauma-patients-at-level-ii-versus-level-i-trauma-centers
#7
Juan P Herrera-Escobar, Arturo J Rios-Diaz, Cheryl Zogg, Lindsey L Wolf, Alyssa Harlow, Eric B Schneider, Zara Cooper, Carlos A Ordonez, Ali Salim, Adil H Haider
BACKGROUND: Severely injured trauma patients have higher in-hospital mortality at Level II versus Level I Trauma Centers (TCs). In order to better understand these differences, we sought to determine if there were any time-periods during which hemodynamically unstable trauma patients are at higher risk of death at Level II versus Level I TCs within the first 24 hours post-admission. STUDY DESIGN: Trauma patients aged 18-64 years, with Injury Severity Score ≥15, SBP <90 mmHg at admission, and treated at Level II or Level I TCs, were identified using the 2007-2012 National Trauma Data Bank...
September 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930746/early-assessment-of-the-risk-factors-for-diabetic-retinopathy-can-reduce-the-risk-of-peripheral-arterial-and-cardiovascular-diseases-in-type-2-diabetes
#8
Juan Tang, Tao Li, Pinhong Li, Yuefei Ma, Momo Liu, Qiaoyun Shan, Fengqi Guo, Ting Zhou, Qianping Wei
BACKGROUNDS: There is still a lack of consensus about how to assess the risk of peripheral arterial disease (PAD) and cardiovascular disease (CVD) in patients with diabetic retinopathy (DR). AIMS: We investigated the risk factors for DR and their association with PAD and CVD in patients with type 2 diabetes (T2D). METHODS: A total of 1,421 patients diagnosed with T2D participated in this study. DR stages were classified as non-DR, nonproliferative DR (NPDR), or proliferative DR (PDR)...
September 21, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28928755/different-preclimacteric-events-in-apple-cultivars-with-modified-ripening-physiology
#9
Vikram Singh, Asya Weksler, Haya Friedman
"Anna" is an early season apple cultivar exhibiting a fast softening and juiciness loss during storage, in comparison to two mid-late season cultivars "Galaxy" and "GD." The poor storage capacity of "Anna" was correlated with high lipid oxidation-related autoluminescence, high respiration and ethylene production rates, associated with high expression of MdACO1, 2, 4, 7, and MdACS1. All cultivars at harvest responded to exogenous ethylene by enhancing ethylene production, typical of system-II. The contribution of pre-climacteric events to the poor storage capacity of "Anna" was examined by comparing respiration and ethylene production rates, response to exogenous ethylene, expression of genes responsible for ethylene biosynthesis and response, and developmental regulators in the three cultivars throughout fruit development...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28928581/a-comparative-study-of-intravenous-esmolol-labetalol-and-lignocaine-in-low-doses-for-attenuation-of-sympathomimetic-responses-to-laryngoscopy-and-endotracheal-intubation
#10
Ekta Ratnani, Om Prakash Sanjeev, Abhishek Singh, Manoj Tripathi, Hemant Kumar Chourasia
BACKGROUND: Direct layngoscopy and endotracheal intubation is a noxious stimuli and induces sympathomimetic responses. Although well tolerated in healthy subjects, it may impose life threatening arrhythmias, left ventricular failure or rupture of cerebral aneurysm in susceptible patients. Esmolol, Labetalol and Lignocaine attenuate these responses but are associated with side effects of bradycardia, hypotension etc. In lower doses, chances of these side effects are comparatively low. So we designed this prospective clinical trial to assess the efficacy of intravenous esmolol, labetalol and lignocaine in low doses for attenuation of sympathomimetic responses to endotracheal intubation...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28928111/personalized-hypertension-management-using-patient-generated-health-data-integrated-with-electronic-health-records-empower-h-six-month-pre-post-study
#11
Nan Lv, Lan Xiao, Martha L Simmons, Lisa G Rosas, Albert Chan, Martin Entwistle
BACKGROUND: EMPOWER-H (Engaging and Motivating Patients Online With Enhanced Resources-Hypertension) is a personalized-care model facilitating engagement in hypertension self-management utilizing an interactive Web-based disease management system integrated with the electronic health record. The model is designed to support timely patient-provider interaction by incorporating decision support technology to individualize care and provide personalized feedback for patients with chronic disease...
September 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28927404/food-intake-patterns-and-cardiovascular-risk-factors-in-japanese-adults-analyses-from-the-2012-national-health-and-nutrition-survey-japan
#12
Nay Chi Htun, Hitomi Suga, Shino Imai, Wakana Shimizu, Hidemi Takimoto
BACKGROUND: There is an increasing global interest in the role of Japanese diet as a possible explanation for the nation's healthy diet, which contributes to the world's highest life-expectancy enjoyed in Japan. However, nationwide studies on current food intake status among general Japanese population have not been established yet. This study examined the association between food intake patterns and cardiovascular risk factors (CVRF) such as waist circumference (WC), body mass index (BMI), blood pressure (SBP, DBP), HbA1c and blood lipid profiles among general Japanese adults...
September 19, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28926870/cardiovascular-responses-to-resistance-exercise-performed-with-large-and-small-muscle-mass
#13
Lenifran Matos-Santos, Paulo Farinatti, Juliana P Borges, Renato Massaferri, Walace Monteiro
Prior research about the effects of the amount of exercised muscle mass upon cardiovascular responses (CVR) has neglected a potential bias related to total exercise and concentric/eccentric duration. Autonomic responses and perceived exertion (RPE) were compared in resistance exercises performed with larger and smaller muscle mass and matched for total exercise and concentric/eccentric duration. Twelve men performed 4 sets of 12 repetitions of unilateral (UNI) and bilateral (BIL) knee extensions at 70% of 12RM...
September 19, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28926573/self-monitoring-of-blood-pressure-in-hypertension-a-systematic-review-and-individual-patient-data-meta-analysis
#14
Katherine L Tucker, James P Sheppard, Richard Stevens, Hayden B Bosworth, Alfred Bove, Emma P Bray, Kenneth Earle, Johnson George, Marshall Godwin, Beverly B Green, Paul Hebert, F D Richard Hobbs, Ilkka Kantola, Sally M Kerry, Alfonso Leiva, David J Magid, Jonathan Mant, Karen L Margolis, Brian McKinstry, Mary Ann McLaughlin, Stefano Omboni, Olugbenga Ogedegbe, Gianfranco Parati, Nashat Qamar, Bahman P Tabaei, Juha Varis, Willem J Verberk, Bonnie J Wakefield, Richard J McManus
BACKGROUND: Self-monitoring of blood pressure (BP) appears to reduce BP in hypertension but important questions remain regarding effective implementation and which groups may benefit most. This individual patient data (IPD) meta-analysis was performed to better understand the effectiveness of BP self-monitoring to lower BP and control hypertension. METHODS AND FINDINGS: Medline, Embase, and the Cochrane Library were searched for randomised trials comparing self-monitoring to no self-monitoring in hypertensive patients (June 2016)...
September 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28925411/birthweight-and-cardiometabolic-risk-patterns-in-multiracial-children
#15
D Sun, T Wang, Y Heianza, T Huang, X Shang, J Lv, S Li, E Harville, W Chen, V Fonseca, L Qi
BACKGROUND/OBJECTIVES: Prenatal growth, which is widely marked by birthweight, may have a pivotal role in affecting the lifelong risk of cardiometabolic disorders; however, comprehensive evaluation of its relations with childhood cardiometabolic risk patterns and the ethnic and gender disparities in national representative populations is still lacking. The aim of this study was to evaluate the associations between birthweight and comprehensive patterns of cardiometabolic risk in a nationally representative sample of children and adolescents...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28922954/determinants-of-carotid-femoral-pulse-wave-velocity-progression-in-hypertensive-patients-over-a-3-7-years-follow-up
#16
Paolo Meani, Alessandro Maloberti, Paola Sormani, Giulia Colombo, Luca Giupponi, Miriam Stucchi, Marisa Varrenti, Paola Vallerio, Rita Facchetti, Guido Grassi, Giuseppe Mancia, Cristina Giannattasio
OBJECTIVE: The role of risk factors on the progression of arterial stiffness has not yet been extensively evaluated. The aim of the current longitudinal study was to evaluate the determinants of the PWV progression over a 4 years follow-up period in hypertensive subjects. MATERIALS AND METHODS: We enrolled 333 consecutive hypertensive outpatients 18-80 aged, followed by the Hypertension Unit of St. Gerardo Hospital (Monza, Italy). At baseline anamnestic, clinical, BP, laboratory data and cfPWV were assessed...
September 18, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28922573/diastolic-blood-pressure-rises-with-the-exacerbation-of-obstructive-sleep-apnea-in-males
#17
Wei Hu, Xian Jin, Chengjun Chen, Peng Zhang, Dandan Li, Qian Su, Guizhi Yin, Yanwen Hang
OBJECTIVE: To characterize the association pattern between blood pressure (BP), metabolism changes, and obstructive sleep apnea (OSA) severity within male OSA patients. METHODS: The association between systolic BP (SBP), diastolic BP (DBP), glucose, lipids, apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and arousal index (ArI) was evaluated after adjustment for BMI and waist circumference/hip circumference ratio (WHR) in 1,370 male OSA patients. RESULTS: In the multiple linear regression models using SBP as an independent variable, SBP did not associate with the increase of any OSA indexes...
September 18, 2017: Obesity
https://www.readbyqxmd.com/read/28922068/influence-of-flaxseed-lignan-supplementation-to-older-adults-on-biochemical-and-functional-outcome-measures-of-inflammation
#18
Yunyun Di, Jennifer Jones, Kerry Mansell, Susan Whiting, Sharyle Fowler, Lilian Thorpe, Jennifer Billinsky, Navita Viveky, Pui Chi Cheng, Ahmed Almousa, Thomas Hadjistavropoulos, Jane Alcorn
Evidence from the literature suggests that dietary flaxseed lignans have the ability to modulate inflammation, which is recognized as the underlying basis of multiple chronic human diseases in older adults. Our objective was to determine the effects of oral lignan supplementation on biochemical and functional indicators of inflammation as well as safety and tolerability in older healthy adults. We designed a randomized, double-blind, placebo-controlled clinical trial in older healthy adults (60-80 years) to assess flaxseed lignan-enriched complex (∼38% secoisolariciresinol diglucoside [SDG]; 600 mg SDG dose) oral supplementation effects on biochemical and functional indicators of inflammation and safety and tolerability in older healthy adults after 6 months of once-daily oral administration...
September 18, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28921862/efficacy-and-safety-of-the-addition-of-ertugliflozin-in-patients-with-type-2-diabetes-mellitus-inadequately-controlled-with-metformin-and-sitagliptin-the-vertis-sita2-placebo-controlled-randomized-study
#19
Samuel Dagogo-Jack, Jie Liu, Roy Eldor, Guillermo Amorin, Jeremy Johnson, Darcy Hille, Yuqin Liao, Susan Huyck, Gregory Golm, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring
AIMS: To assess ertugliflozin in patients with type 2 diabetes inadequately controlled on metformin and sitagliptin. MATERIALS AND METHODS: In this double-blind randomized study (NCT02036515), patients (glycated haemoglobin [HbA1c] 7.0-10.5% [53-91 mmol/mol] on metformin ≥1500 mg/day and sitagliptin 100 mg/day; estimated glomerular filtration rate [eGFR] ≥60 mL/min/1.73 m(2) ) were randomized to ertugliflozin 5 mg once-daily, 15 mg once-daily, or placebo. Primary efficacy endpoint was change from baseline in HbA1c at Week 26; treatment was continued until Week 52...
September 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28921455/construction-of-an-hrp-streptavidin-bound-antigen-and-its-application-in-an-elisa-for-porcine-circovirus-2-antibodies
#20
Meng Ge, Run-Cheng Li, Tailong Qu, Wenjie Gong, Xing-Long Yu, Changchun Tu
A fusion protein SBP-Cap∆41, consisting of Cap∆41 (without 41 amino acids at the N-terminus) protein of porcine circovirus 2 (PCV2) and a streptavidin binding peptide (SBP), was constructed. This fusion protein binds to HRP-labeled streptavidin (HRP-SA) through high affinity between SBP and SA, forming an HRP-streptavidin bound antigen (Hsb-Ag) with both immunoreactivity and enzymatic activity, which can be used in a double-antigen sandwich ELISA for detection of PCV2 antibodies. Comparison of the characteristics of the HSb-Cap∆41 and chemical conjugates of the recombinant Cap∆41 protein showed that the HSb-Cap∆41 based double-antigen sandwich ELISA (HBDS-ELISA) had higher specificity and sensitivity...
September 18, 2017: AMB Express
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