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https://www.readbyqxmd.com/read/28230786/sex-specificity-of-mineralocorticoid-target-gene-expression-during-renal-development-and-long-term-consequences
#1
Laurence Dumeige, Caroline Storey, Lyvianne Decourtye, Melanie Nehlich, Christophe Lhadj, Say Viengchareun, Laurent Kappeler, Marc Lombès, Laetitia Martinerie
Sex differences have been identified in various biological processes, including hypertension. The mineralocorticoid signaling pathway is an important contributor to early arterial hypertension, however its sex-specific expression has been scarcely studied, particularly with respect to the kidney. Basal systolic blood pressure (SBP) and heart rate (HR) were measured in adult male and female mice. Renal gene expression studies of major players of mineralocorticoid signaling were performed at different developmental stages in male and female mice using reverse transcription quantitative PCR (RT-qPCR), and were compared to those of the same genes in the lung, another mineralocorticoid epithelial target tissue that regulates ion exchange and electrolyte balance...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230063/effects-of-calcium-plus-vitamin-d-supplementation-on-blood-pressure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
L Wu, D Sun
The effect of calcium or vitamin D supplement on blood pressure (BP) has been explored in previous meta-analyses, but the results are conflicting. The combined efficacy of calcium and vitamin D on BP has not been systematically assessed. Thus, we conducted a meta-analysis of randomized controlled trials (RCTs) to explore the effect of calcium plus vitamin D (CaD) supplementation on changes of systolic blood pressure (SBP) and diastolic blood pressure among male and female participants (with and without diagnosed hypertension) aged 18 years or older...
February 23, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28227971/a-feature-exploration-methodology-for-learning-based-cuffless-blood-pressure-measurement-using-photoplethysmography
#3
Kefeng Duan, Zhiliang Qian, Mohamed Atef, Guoxing Wang, Kefeng Duan, Zhiliang Qian, Mohamed Atef, Guoxing Wang, Zhiliang Qian, Kefeng Duan, Guoxing Wang, Mohamed Atef
In this work, we propose a feature exploration method for learning-based cuffless blood pressure measurement. More specifically, to efficiently explore a large feature space from the photoplethysmography signal, we have applied several analytical techniques, including random error elimination, adaptive outlier removal, maximum information coefficient and Pearson's correlation coefficient based feature assessment methods. We evaluate fifty-seven possible feature candidates and propose three separate feature sets with each containing eleven features to predict the systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP), respectively...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227114/photoplethysmography-derivatives-and-pulse-transit-time-in-overnight-blood-pressure-monitoring
#4
Sobhan Salari Shahrbabaki, Beena Ahmed, Thomas Penzel, Dean Cvetkovic, Sobhan Salari Shahrbabaki, Beena Ahmed, Thomas Penzel, Dean Cvetkovic, Sobhan Salari Shahrbabaki, Beena Ahmed, Thomas Penzel, Dean Cvetkovic
Overnight continuous blood pressure measurement provides simultaneous monitoring of blood pressure and sleep architecture. By this means, we are able to investigate whether different sleep events are associated to blood pressure fluctuations. In this paper, we used the Pulse Transit Time (PTT) to develop and evaluate functions for measurement of blood pressure. We focused on the first and second derivatives of fingertip Photoplethysmography (PPG) recordings to detect PPG critical points. By applying R wave of ECG and PPG critical points, we created two PTT-based models for estimation of systolic and diastolic blood pressure (SBP and DBP)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226984/analysis-of-causal-cardio-postural-interaction-under-orthostatic-stress-using-convergent-cross-mapping
#5
Ajay K Verma, Amanmeet Garg, Andrew Blaber, Reza Fazel-Rezai, Kouhyar Tavakolian, Ajay K Verma, Amanmeet Garg, Andrew Blaber, Reza Fazel-Rezai, Kouhyar Tavakolian, Ajay K Verma, Amanmeet Garg, Kouhyar Tavakolian, Reza Fazel-Rezai, Andrew Blaber
Knowledge of a cause-and-effect relationship between different physiological systems is helpful in predicting their performance under perturbations, such as orthostatic challenge. The causal coupling between representative signals of the cardiovascular and postural systems under orthostatic challenge remains unknown. Understanding the causal relationship between these two systems is critical, as their interplay is vital to maintain stable upright posture of the human body during quiet standing. In this research, convergent cross mapping (CCM) method was applied to study the causal relationship between the cardiovascular and postural systems previously shown to have coherent activity during quiet standing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226589/arterial-pressure-beat-to-beat-characterization-during-post-occlusive-reactive-hyperemia
#6
L J Cymberknop, C R Arbeitman, M R Alfonso, I Farro, R L Armentano, L J Cymberknop, C R Arbeitman, M R Alfonso, I Farro, R L Armentano, R L Armentano, M R Alfonso, I Farro, L J Cymberknop, C R Arbeitman
INTRODUCTION: In recent years, peripheral arterial tonometry (PAT, a non-invasive and reproducible technique) has gained considerable interest. In this sense, arterial capacity to react to vasoactive stimulus (induced by reactive hyperemia) is known as vascular reactivity (VR). OBJECTIVE: Post ischemic beat to beat VR characterization was performed based on PAT measurements. METHODS: Systolic Blood Pressure (SBP) and Augmentation index (AIx) variations were modeled, as a response to flow stimulus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226573/a-preliminary-study-on-multi-wavelength-ppg-based-pulse-transit-time-detection-for-cuffless-blood-pressure-measurement
#7
Jing Liu, Yuan-Ting Zhang, Xiao-Rong Ding, Wen-Xuan Dai, Ni Zhao, Jing Liu, Yuan-Ting Zhang, Xiao-Rong Ding, Wen-Xuan Dai, Ni Zhao, Wen-Xuan Dai, Yuan-Ting Zhang, Xiao-Rong Ding, Ni Zhao, Jing Liu
Pulse transit time (PTT) has been widely studied as an index of blood pressure (BP) changes. In recent years, some prototypes of PTT-based wearable BP measurement devices have been developed, which can relieve users from the discomfort caused by the inflating cuff used in auscultatory and oscillometric BP measurement techniques. However, in the common practice for PTT detection, multi-site sensor implementation on human body is required, making it difficult for the integration of wearable devices. Since multi-wavelength (MW) photoplethysmogram (PPG) signals carry blood pulsation information of different blood vessels embedded in different skin depths, the time difference between different wavelength PPG signals collected at the same body site can be treated as a special PTT on a short length of blood vessels beneath the skin...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226571/cuff-less-ppg-based-continuous-blood-pressure-monitoring-a-smartphone-based-approach
#8
Aman Gaurav, Maram Maheedhar, Vijay N Tiwari, Rangavittal Narayanan, Aman Gaurav, Maram Maheedhar, Vijay N Tiwari, Rangavittal Narayanan, Maram Maheedhar, Rangavittal Narayanan, Vijay N Tiwari, Aman Gaurav
Cuff-less estimation of systolic (SBP) and diastolic (DBP) blood pressure is an efficient approach for non-invasive and continuous monitoring of an individual's vitals. Although pulse transit time (PTT) based approaches have been successful in estimating the systolic and diastolic blood pressures to a reasonable degree of accuracy, there is still scope for improvement in terms of accuracies. Moreover, PTT approach requires data from sensors placed at two different locations along with individual calibration of physiological parameters for deriving correct estimation of systolic and diastolic blood pressure (BP) and hence is not suitable for smartphone deployment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225859/prevalence-of-metabolic-syndrome-in-pre-and-postmenopausal-women
#9
Ricardo de Marchi, Cátia Millene Dell'Agnolo, Tiara Cristina Romeiro Lopes, Angela Andréia França Gravena, Marcela de Oliveira Demitto, Sheila Cristina Rocha Brischiliari, Deise Helena Pelloso Borghesan, Maria Dalva de Barros Carvalho, Sandra Marisa Pelloso
Objective: The objective of this study was to determine the prevalence of metabolic syndrome (MS) and its components among pre- and postmenopausal women, as well as the association between menopausal status and MS. Materials and methods: A retrospective study was conducted at a reference cardiology outpatient clinic in a city located in Northwestern Paraná State, Brazil. A total of 958 medical records of symptomatic climacteric women evaluated between 2010 and 2014 were analyzed...
February 16, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225488/association-between-beat-to-beat-blood-pressure-variability-and-vascular-elasticity-in-normal-young-adults-during-the-cold-pressor-test
#10
Yufa Xia, Dan Wu, Zhifan Gao, Xin Liu, Qian Chen, Lijie Ren, Wanqing Wu
The beat-to-beat blood pressure (BP) monitoring parameters, such as average beat-to-beat BP, BP variability (BPV), could have an influence on the vascular elasticity. This study hypothesized that the elevated beat-to-beat BPV could evoke the reduction of the vascular elasticity independent of BP levels. We measured the beat-to-beat BP recordings and total arterial compliance (TAC), which was used to assess the vascular elasticity, in 80 young healthy adults during the cold pressor test (CPT). The CPT included 3 phases: baseline phase, cold stimulus phase, recovery phase...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225023/traditional-chinese-medicine-suppresses-left-ventricular-hypertrophy-by-targeting-extracellular-signal-regulated-kinases-signaling-pathway-in-spontaneously-hypertensive-rats
#11
Xingjiang Xiong, Xiaochen Yang, Lian Duan, Wei Liu, Yun Zhang, Yongmei Liu, Pengqian Wang, Shengjie Li, Xiaoke Li
Chinese herbal medicine Bu-Shen-Jiang-Ya decoction (BSJYD) is reported to be beneficial for hypertension. Over expression of extracellular signal regulated kinases (ERK) pathway plays an important role in left ventricular hypertrophy (LVH). This study aimed to observe effects of BSJYD on LVH in spontaneously hypertensive rats (SHRs) and explore its possible mechanism on regulation of ERK pathway. Sixty 12-week-old SHRs were randomly allocated into 5 groups: BSJYD high dose group, middle dose group, low dose group, captopril group, and control group...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224694/the-clinical-relevance-of-orthostatic-hypotension-in-elderly-patients
#12
Laura Hartog, Nanne Kleefstra, Rene Luigies, Sophia de Rooij, Henk Bilo, Kornelis van Hateren
AIM: Orthostatic hypotension (OH) is highly prevalent in old age. The impact of OH on orthostatic complaints and falling is questionable. We wondered if the consensus definition of OH plays an essential role in the accuracy and direction of the prediction of these endpoints. We aimed to explore the relation between different definitions of OH, including relative decrease of blood pressure, and orthostatic complaints and falling. METHODS: A cross-sectional study was performed with 1415 participants aged ≥65 years visiting a mobile fall-prevention team...
February 22, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28222633/association-of-blood-pressure-in-the-supine-position-with-target-organ-damage-in-subjects-over-60-years-old
#13
Feng Wang, Hualing Zhao, Chao Yang, Guilan Kong, Lu Song, Chunhui Li, Yiming Wang, Shuohua Chen, Jing Wang, Shouling Wu
Objective Toexplore the correlation between blood pressure in the supine position and target organ damage in subjects over 60 years of age. Methods In 2444 individuals, we investigated the association of systolic blood pressure (SBP) in the supine position with the target organ damage indices microalbuminuria (ALBU), brachial-ankle pulse wave velocity (baPWV), and carotid intima-media thickness (IMT). Supine hypertension (SH) is defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28222365/the-cessation-of-the-long-term-exposure-to-low-doses-of-mercury-ameliorates-the-increase-in-systolic-blood-pressure-and-vascular-damage-in-rats
#14
Danize Aparecida Rizzetti, João Guilherme Dini Torres, Alyne Goulart Escobar, Taiz Martins da Silva, Paola Zambelli Moraes, Raquel Hernanz, Franck Maciel Peçanha, Marta Miguel Castro, Dalton Valentim Vassallo, Mercedes Salaices, Maria Jesús Alonso, Giulia Alessandra Wiggers
This study aimed to verify whether a prolonged exposure to low-level mercury promotes haemodynamic disorders and studied the reversibility of this vascular damage. Rats were divided into seven groups: three control groups received saline solution (im) for 30, 60 or 90 days; two groups received HgCl2 (im, first dose, 4.6μg/kg, subsequent doses 0.07μg/kg/day) for 30 or 60 days; two groups received HgCl2 for 30 or 60 days (im, same doses) followed by a 30-day washout period. Systolic blood pressure (SBP) was measured, along with analysis of vascular response to acetylcholine (ACh) and phenylephrine (Phe) in the absence and presence of endothelium, a nitric oxide (NO) synthase inhibitor, an NADPH oxidase inhibitor, superoxide dismutase, a non-selective cyclooxygenase (COX) inhibitor and an AT1 receptor blocker...
February 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28222036/vascular-risk-factors-are-associated-with-retinal-arteriolar-narrowing-and-venular-widening-in-children-and-adolescents-with-type-1-diabetes
#15
Stuart Keel, Catherine Itsiopoulos, Konstandina Koklanis, Meri Vukicevic, Fergus Cameron, Laima Brazionis
BACKGROUND: The aim of the study was to describe the relationship of retinal arteriolar and venular calibre with vascular risk factors in children and adolescents with type 1 diabetes. METHODS: In this hospital-based cross-sectional study, the medical files of 483 children and adolescents with type 1 diabetes were audited to collect retinal images and relevant clinical data. Retinal vascular calibre was measured using standardised protocols. RESULTS: After multivariable adjustments, a vascular risk profile that included: older age, higher serum creatinine, higher systolic blood pressure (SBP), higher body mass index (BMI), abnormal estimated glomerular filtration rate (eGFR), lower high-density lipoproteins (HDL) cholesterol, longer duration of diabetes and higher serum sodium was associated with narrower central retinal artery equivalent (CRAE) (95% CI=-4...
February 21, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28220817/a-simple-approach-for-preparation-of-affinity-matrices-simultaneous-purification-and-reversible-immobilization-of-a-streptavidin-mutein-to-agarose-matrix
#16
Sau-Ching Wu, Chris Wang, Dave Hansen, Sui-Lam Wong
SAVSBPM18 is an engineered streptavidin for affinity purification of both biotinylated biomolecules and recombinant proteins tagged with streptavidin binding peptide (SBP) tags. To develop a user-friendly approach for the preparation of the SAVSBPM18-based affinity matrices, a designer fusion protein containing SAVSBPM18 and a galactose binding domain was engineered. The galactose binding domain derived from the earthworm lectin EW29 was genetically modified to eliminate a proteolytic cleavage site located at the beginning of the domain...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219804/the-immediate-cardiovascular-response-to-joint-mobilization-of-the-neck-a-randomized-placebo-controlled-trial-in-pain-free-adults
#17
Emmanuel Y Yung, Cheongeun Oh, Michael S Wong, Jason K Grimes, Erica M Barton, Muhammad I Ali, David Cameron
BACKGROUND: Some normotensive patients can have a spike in resting systolic blood pressure (SBP) in response to acute neck pain. Applying the typical dosage of mobilization may potentially result in a sympatho-excitatory response, further increasing resting SBP. Therefore, there is a need to explore other dosage regimens that could result in a decrease in SBP. OBJECTIVES: To compare the blood pressure (BP) and heart rate (HR) response of pain-free, normotensive adults when receiving unilateral posterior-to-anterior mobilization (PA) applied to the neck versus its corresponding placebo (PA-P)...
February 4, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28217594/effectiveness-of-yoga-program-in-the-management-of-diabetes-using-community-health-workers-in-the-urban-slums-of-bangalore-city-a-non-randomized-controlled-trial
#18
Hemavathi Dasappa, Farah Naaz Fathima, Rugmani Prabhakar
TRIAL DESIGN: Nonrandomized controlled trial. METHODS: Nonrandomized controlled trial. This was an interventional study that was conducted in 4 slums of Bengaluru. Of the 256 diabetes participants, only 109 people agreed to participate in the program. Of 109 people, 52 people agreed to participate in the intervention (agreed to learn and practice Yoga) while the remaining 57 people were assigned to nonintervention group. Randomization and blinding could not be done...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28216283/life-course-path-analysis-of-total-and-central-adiposity-throughout-adolescence-on-adult-blood-pressure-and-insulin-resistance
#19
J Araújo, M Severo, S Santos, E Ramos
BACKGROUND AND AIM: We aimed to study whether the effect of adolescent adiposity on adult blood pressure and insulin resistance was mediated by adult adiposity. METHODS AND RESULTS: Data from the EPITeen cohort at 13, 17 and 21 years was used (n = 2211). Sex- and age-specific body mass index z-scores (BMIz) and waist-to-hip ratio (WHR) were used as indicators of total and central adiposity, respectively. Systolic blood pressure (SBP), glucose and insulin were assessed at 21 years and the homeostasis model assessment (HOMA-IR) was used as a marker of insulin resistance...
December 24, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28215413/ratio-of-systolic-blood-pressure-to-right-atrial-pressure-a-novel-marker-to-predict-morbidity-and-mortality-in-acute-systolic-heart-failure
#20
Hesham R Omar, Richard Charnigo, Maya Guglin
Congestion is the main contributor to heart failure (HF) morbidity and mortality. We assessed the combined role of congestion and decreased forward flow in predicting morbidity and mortality in acute systolic HF. The Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness trial data set was used to determine if the ratio of simultaneously measured systolic blood pressure (SBP)/right atrial pressure (RAP) on admission predicted HF rehospitalization and 6-month mortality...
January 6, 2017: American Journal of Cardiology
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