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https://www.readbyqxmd.com/read/28725953/prognostic-significance-of-low-systolic-blood-pressure-at-discharge-in-patients-with-heart-failure-and-preserved-ejection-fraction
#1
Shijun Li, Xiaoying Li
INTRODUCTION: Systolic blood pressure (SBP) is emerging as a predictor of outcome in chronic heart failure and low SBP has been shown to be related to higher mortality. AIM: To investigate the relationship between low SBP and long-term outcome in patients with heart failure with preserved ejection fraction (HFpEF). METHODS: We use prospectively collected data and recruited 297 patients with chronic HFpEF to investigate the relationship between low SBP at discharge and long-term outcome...
July 19, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28725455/effect-of-respiratory-pattern-on-automated-clinical-blood-pressure-measurement-an-observational-study-with-normotensive-subjects
#2
Natalia Herakova, Nnenna Harmony Nzeribe Nwobodo, Ying Wang, Fei Chen, Dingchang Zheng
BACKGROUND: It has been reported that deep breathing could reduce blood pressures (BP) in general. It is also known that BP is decreased during inhalation and increased during exhalation. Therefore, the measured BPs could be potentially different during deep breathing with different lengths of inhalation and exhalation. This study aimed to quantitatively investigate the effect of different respiratory patterns on BPs. METHODS: Forty healthy subjects (20 males and 20 females, aged from 18 to 60 years) were recruited...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28724644/the-effect-of-magnesium-supplementation-on-blood-pressure-in-individuals-with-insulin-resistance-prediabetes-or-noncommunicable-chronic-diseases-a-meta-analysis-of-randomized-controlled-trials
#3
Daniel T Dibaba, Pengcheng Xun, Yiqing Song, Andrea Rosanoff, Michael Shechter, Ka He
Background: To our knowledge, the effect of magnesium supplementation on blood pressure (BP) in individuals with preclinical or noncommunicable diseases has not been previously investigated in a meta-analysis, and the findings from randomized controlled trials (RCTs) have been inconsistent.Objective: We sought to determine the pooled effect of magnesium supplementation on BP in participants with preclinical or noncommunicable diseases.Design: We identified RCTs that were published in English before May 2017 that examined the effect of magnesium supplementation on BP in individuals with preclinical or noncommunicable diseases through PubMed, ScienceDirect, Cochrane, clinicaltrials...
July 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28723834/talking-with-a-doctor-during-a-visit-elicits-increases-in-systolic-and-diastolic-blood-pressure
#4
Wenqiang Qi, Qinghua Wu, Yanqing Wu, Qiang Peng, Ping Li, Xiaoshu Cheng, Hai Su
OBJECTIVE: To investigate the impact of talking with doctors on blood pressure (BP) in outpatients. PATIENTS AND METHODS: This study included 122 hypertensive and 78 normotensive outpatients. BP was measured initially in silence with oscillometric BP monitors three times at 1-min intervals as follows: pre-1, pre-2, and pre-3. BP was then measured with the same device immediately, at 3 min, and at 5 min after talking commenced as follows: during-1, during-3, and during-5...
July 18, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28723587/evaluation-of-an-electronic-clinical-decision-support-tool-for-incident-elevated-bp-in-adolescents
#5
Elyse Olshen Kharbanda, Stephen E Asche, Alan Sinaiko, James D Nordin, Heidi L Ekstrom, Patricia Fontaine, Steven P Dehmer, Nancy E Sherwood, Patrick J O'Connor
OBJECTIVE: To evaluate, among adolescents 10-17 years with an incident hypertensive BP (≥95(th) percentile) at a primary care visit, whether TeenBP, a novel electronic health record (EHR) linked clinical decision support tool (CDS), improved recognition of elevated BP and return for follow-up BP evaluation. METHODS: We conducted a pragmatic cluster randomized trial in 20 primary care clinics in a large Midwestern medical group. Ten clinics received the TeenBP CDS, including an alert to remeasure a hypertensive BP at that visit, an alert that a hypertensive BP should be repeated in 1-3 weeks and patient-specific order sets...
July 16, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28722115/transcriptional-profiling-of-mechanically-and-genetically-sink-limited-soybeans
#6
Anne V Brown, Karen A Hudson
The absence of a reproductive sink causes physiological and morphological changes in soybean plants. These include increased accumulation of nitrogen and starch in the leaves and delayed leaf senescence. To identify transcriptional changes that occur in leaves of these sink-limited plants, we used RNAseq to compare gene expression levels in trifoliate leaves from depodded and ms6 male sterile soybean plants and control plants. In both sink-limited tissues, we observed a deferral of the expression of senescence-associated genes and a continued expression of genes associated with leaf maturity...
July 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28721143/the-effect-of-antihypertensive-treatment-on-arterial-stiffness-and-serum-concentration-of-selected-matrix-metalloproteinases
#7
Marek Rajzer, Wiktoria Wojciechowska, Tomasz Kameczura, Agnieszka Olszanecka, Danuta Fedak, Michał Terlecki, Kalina Kawecka-Jaszcz, Danuta Czarnecka
INTRODUCTION: The aim of the study was to assess the arterial stiffness and serum levels of selected metalloproteinases (MMPs) in hypertensive patients and their changes following antihypertensive therapy. MATERIAL AND METHODS: The study group consisted of 95 patients with essential arterial hypertension (HT) stage 1 or 2 (mean age: 53.1 ±13.0 years). The control group consisted of 31 normotensives of the same age range. Hypertension patients were randomized to one of the following monotherapies for 6 months: quinapril, losartan, amlodipine, hydrochlorothiazide or bisoprolol...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28719490/identification-of-hypotensive-emergency-department-patients-with-cardiogenic-etiologies
#8
Daniel J Henning, Kathleen E Kearney, M Kennedy Hall, Claudius Mahr, Nathan I Shapiro, Graham Nichol
OBJECTIVE: Identify predictors of cardiogenic etiology among Emergency Department (ED) patients with hypotension, and use these predictors to create a clinical tool to discern cardiogenic etiology of hypotension. METHODS: This secondary analysis evaluated a prospective cohort of consecutive patients with hypotension in an urban, academic, tertiary care ED from November 2012 to September 2013. We included adults with hypotension, defined as a new vasopressor requirement, systolic blood pressure (SBP) < 90 mmHg after at least 1L of crystalloid or 2 units packed red blood cells, or SBP < 90 mmHg and fluids withheld due to concern for fluid overload...
July 17, 2017: Shock
https://www.readbyqxmd.com/read/28718663/time-trends-and-socioeconomic-differences-in-blood-pressure-levels-the-northern-sweden-monica-study-1994-2014
#9
Marie Eriksson, Bo Carlberg, Johanna Pennlert, Stefan Söderberg, Mats Eliasson
Background People with low socioeconomic status have higher blood pressure (BP), increasing their risk of myocardial infarction and stroke. We hypothesized that the gap in systolic (SBP) and diastolic (DBP) BP, according to educational level, has decreased over time but, that economical vulnerability would confer higher BP. Methods A total of 4564 women and 4363 men aged 25-74 years participated in five population-based surveys in the Northern Sweden MONICA study between 1994 and 2014 (participation rate 76...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28716309/arginine-vasopressin-copeptin-and-the-development-of-relative-avp-deficiency-in-hemorrhagic-shock
#10
Carrie A Sims, Yuxia Guan, Meredith Bergey, Rebecca Jaffe, Lilias Holmes-Maguire, Niels Martin, Patrick Reilly
BACKGROUND: Arginine vasopressin (AVP) is critical for maintaining vasomotor tone and low levels have been associated with the development of irreversible shock. We investigated the clinical relationship between AVP, copeptin (the C-terminal fragment of the AVP precursor), and the development of relative AVP deficiency following hemorrhagic shock. METHODS: A prospective, observational study of 21 hypotensive (SBP<90 mmHg X 2) or presumptively bleeding trauma patients was conducted...
June 24, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28711972/the-relationship-of-blood-glucose-with-cardiovascular-disease-is-mediated-over-time-by-traditional-risk-factors-in-type-1-diabetes-the-dcct-edic-study
#11
Ionut Bebu, Barbara H Braffett, Rodica Pop-Busui, Trevor J Orchard, David M Nathan, John M Lachin
AIMS/HYPOTHESIS: Chronic hyperglycaemia, as measured by HbA1c levels, is a major risk factor for atherosclerosis and cardiovascular disease (CVD) in type 1 diabetes. Our aim was to describe the degree to which the effect of HbA1c on the risk of CVD is mediated by its effect on traditional risk factors over time, and how these mediation pathways change over time. METHODS: The DCCT and its observational follow-up study, the Epidemiology of Diabetes Interventions and Complications (EDIC), followed 1441 participants for a mean of 27 years, with periodic measurement of HbA1c and risk factors over time...
July 16, 2017: Diabetologia
https://www.readbyqxmd.com/read/28710615/aldosterone-antagonist-therapy-and-its-relationship-with-inflammation-fibrosis-thrombosis-mineral-bone-disorder-and-cardiovascular-complications-in-peritoneal-dialysis-pd-patients
#12
Rafał Donderski, Paweł Stróżecki, Beata Sulikowska, Magdalena Grajewska, Ilona Miśkowiec, Anna Stefańska, Joanna Siódmiak, Grażyna Odrowąż-Sypniewska, Jacek Manitius
BACKGROUND: High aldosterone level may contribute to pathogenesis of hypertension, vessels damage and cardiovascular system deterioration in chronic kidney disease patients. Besides its classical action via mineralocorticoid receptor, aldosterone is also involved in cell growth, inflammation, oxidative stress, endothelial dysfunction and exerts fibroproliferative effects. The aim of the study was to assess whether aldosterone antagonist treatment may influence serum level of inflammatory, fibrosis, thrombosis and mineral-bone metabolism markers in peritoneal dialysis (PD) patients and blood pressure, aortic stiffness, echocardiographic indices after 12 months of treatment...
July 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28710276/atp-binding-and-hydrolysis-disrupts-the-high-affinity-interaction-between-the-heme-abc-transporter-hmuuv-and-its-cognate-substrate-binding-protein
#13
Hiba Qasem Abdullah, Michal Perach, Nurit Livnat-Levanon, Oded Lewinson
Using the energy of ATP hydrolysis ABC transporters catalyze the trans-membrane transport of molecules. In bacteria they partner with a high affinity substrate binding protein (SBP) to import essential micronutrients. ATP binding by Type-I ABC transporters (importers of amino acids, sugars, peptides, small ions) stabilizes the interaction between the transporter and the SBP, thus allowing transfer of the substrate from the latter to the former. In Type-II ABC transporters (importers of trace elements, e.g., vitamin B12, heme, iron-siderophores) the role of ATP remains debatable...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28710073/zinc-mediates-the-srebp-scd-axis-to-regulate-lipid-metabolism-in-caenorhabditis-elegans
#14
Jing-Jing Zhang, Jun-Jun Hao, Yu-Ru Zhang, Yan-Li Wang, Ming-Yi Li, Hui-Lai Miao, Xiao-Ju Zou, Bin Liang
Maintenance of lipid homeostasis is crucial for cells in response to lipid requirements or surplus. The SREBPs transcription factors play essential roles in regulating lipid metabolism and are associated with many metabolic diseases. However, SREBP regulation of lipid metabolism is still less understood. Here, we show that reduction of SBP-1, the only homologue of SREBPs in C. elegans, surprisingly leads to high level of zinc. On the contrary, zinc reduction by mutation of sur-7, encoding a member of the cation diffusion facilitator (CDF) family, restores the fat accumulation and fatty acid profile of sbp-1(ep79) mutant...
July 14, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28709822/occurrence-of-trigeminocardiac-reflex-during-dental-implant-surgery-an-observational-prospective-study
#15
James I-Sheng Huang, Hui-Chieh Yu, Yu-Chao Chang
BACKGROUND/PURPOSE: Trigeminocardiac reflex (TCR) is a clinical phenomenon that manifests as s sudden onset of hemodynamic perturbations. TCR has been reported in cranio-maxillofacial surgery resulting in severe medical risks. Monitoring the hemodynamic changes during cranio-maxillofacial surgery can provide important information to ensure the continuous evaluation of patient's physical conditions. This prospective observational study was conducted to determine the hemodynamic alterations related to the possibly of occurrence of TCR in patients during dental implant surgery...
July 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28709559/blood-pressure-components-and-the-risk-for-proteinuria-in-japanese-men-the-kansai-healthcare-study
#16
Mikiko Shibata, Kyoko Kogawa Sato, Shinichiro Uehara, Hideo Koh, Shigeki Kinuhata, Keiko Oue, Hiroshi Kambe, Michio Morimoto, Tomoshige Hayashi
BACKGROUND: We examined prospectively which of the four blood pressure (BP) components (systolic BP [SBP], diastolic BP [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) was best in predicting the risk of proteinuria. METHODS: This prospective study included 9341 non-diabetic Japanese middle-aged men who had no proteinuria and an estimated glomerular filtration rate ≥60 mL/min/1.73 m(2) and were not taking antihypertensive medications at entry. Persistent proteinuria was defined if proteinuria was detected two or more times consecutively and persistently at the annual examination until the end of follow-up...
July 11, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28707603/ginseng-for-the-treatment-of-hypertension-a-systematic-review-and-meta-analysis-of-double-blind-randomized-placebo-controlled-trials
#17
Hye Won Lee, Hyun- Ja Lim, Ji Hee Jun, Jiae Choi, Myeong Soo Lee
BACKGROUND: Evidence of ginseng for reducing blood pressure (BP) in hypertensive patients is controversial. This systematic review updated the previous reviews and evidence for it. METHODS: Ten databases were searched from their inception through October 2016, without language restriction. Randomized clinical trials (RCTs) were included if any types of ginseng were tested as the sole treatment or as an adjunct to other treatments for pre-hypertension or hypertension...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28707234/the-elusive-search-for-optimal-blood-pressure-targets
#18
REVIEW
Alan H Gradman
BP treatment thresholds/targets determine when to initiate treatment and to what level BP should be reduced. The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) recommended a target of <140/90 for most patients and a target <130/80 mmHg for patients with diabetes or chronic kidney disease. Subsequently, meta-analyses, retrospective studies relating on-treatment BP to clinical outcomes and two large, randomized clinical trials (RCTs) have re-evaluated BP targets...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28706490/effects-of-6-weeks-high-intensity-interval-training-in-schoolchildren-with-insulin-resistance-influence-of-biological-maturation-on-metabolic-body-composition-cardiovascular-and-performance-non-responses
#19
Cristian Alvarez, Rodrigo Ramírez-Campillo, Robinson Ramírez-Vélez, Mikel Izquierdo
Background: Previous studies have observed significant heterogeneity in the magnitude of change in measures of metabolic response to exercise training. There are a lack of studies examining the prevalence of non-responders (NRs) in children while considering other potential environmental factors involved such as biological maturation. Aim: To compare the effects and prevalence of NRs to improve the insulin resistance level (by HOMA-IR), as well as to other anthropometric, cardiovascular, and performance co-variables, between early (EM) and normal maturation (NM) in insulin-resistance schoolchildren after 6-weeks of HIIT...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28704258/effect-of-alternating-standing-and-sitting-on-blood-pressure-and-pulse-wave-velocity-during-a-simulated-workday-in-adults-with-overweight-obesity
#20
Bethany Barone Gibbs, Robert J Kowalsky, Sophy J Perdomo, John M Taormina, Jeffrey R Balzer, John M Jakicic
OBJECTIVE: Reducing prolonged sitting at work has been recommended by an expert panel, but whether intermittent standing improves vascular health is unclear. We aimed to test whether using a sit-stand desk could reduce blood pressure (BP) and pulse wave velocity (PWV) during a simulated workday. METHODS: Overweight/obese adults with pre-to-Stage 1 hypertension completed a randomized crossover study with two simulated workday conditions: STAND-SIT (alternating standing and sitting condition every 30 min) and SIT (continuous sitting condition)...
July 12, 2017: Journal of Hypertension
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