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https://www.readbyqxmd.com/read/28421144/prevalence-of-sarcopenic-obesity-in-adults-with-class-ii-iii-obesity-using-different-diagnostic-criteria
#1
Carlene A Johnson Stoklossa, Arya M Sharma, Mary Forhan, Mario Siervo, Raj S Padwal, Carla M Prado
Background/Objective. Sarcopenic obesity (SO) is a hidden condition of reduced lean soft tissue (LST) in context of excess adiposity. SO is most commonly reported in older adults and both its risk and prevalence increase with age. A variety of body composition indices and cut points have been used to define this condition, leading to conflicting prevalence and risk prediction. Here, we investigate variability in the prevalence of SO in an adult sample of individuals with class II/III obesity (BMI ≥ 35 kg/m(2)) using different diagnostic criteria...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28410342/sarcopenia-is-common-in-overweight-patients-with-inflammatory-bowel-disease-and-may-predict-need-for-surgery
#2
Dawn W Adams, Shelly Gurwara, Heidi J Silver, Sara N Horst, Dawn B Beaulieu, David A Schwartz, Douglas L Seidner
BACKGROUND: Inflammatory bowel disease (IBD) is associated with altered body composition, such as low muscle mass, which affects clinical outcomes. Body composition changes in overweight patients with IBD are less understood. The study aim was to determine the prevalence of sarcopenic overweight and obese patients in a cohort of patients with IBD starting new anti-tumor necrosis factor-α therapy and examine differences in response. METHODS: This is a retrospective review of patients with IBD starting a new anti-tumor necrosis factor-α medication that had computed tomography within 3 months of initiation...
April 13, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28407041/effects-of-low-muscle-mass-on-albuminuria-and-chronic-kidney-disease-in-patients-with-type-2-diabetes-the-korean-sarcopenic-obesity-study-ksos
#3
Hye Soo Chung, Soon Young Hwang, Ju Hee Choi, Hyun Jung Lee, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Dong Seop Choi, Sei Hyun Baik, Kyung Mook Choi
Background: Previous studies have shown that chronic kidney disease (CKD) is associated with accelerated loss of skeletal muscle in patients on dialysis. However, the relationships of sarcopenia with albuminuria and early-stage CKD in patients with type 2 diabetes have not been examined. Methods: We analyzed diabetic subgroup data from 409 patients with type 2 diabetes from the Korean Sarcopenic Obesity Study (KSOS). Sarcopenia was defined as a skeletal muscle mass index (SMI; SMI [%] = total skeletal muscle mass [kg]/weight [kg] × 100) less than 2 SD below the sex-specific mean for a younger reference group...
April 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28396974/sarcopenic-overweight-is-associated-with-early-acute-limiting-toxicity-of-anti-pd1-checkpoint-inhibitors-in-melanoma-patients
#4
Heidelberger Valentine, Goldwasser François, Kramkimel Nora, Jouinot Anne, Huillard Olivier, Boudou-Rouquette Pascaline, Chanal Johan, Arrondeau Jennifer, Franck Nathalie, Alexandre Jérôme, Blanchet Benoît, Leroy Karen, Avril Marie-Françoise, Dupin Nicolas, Aractingi Sélim
Little is known on factors predicting toxicity of anti-PD1 checkpoint inhibitors. Sarcopenic obesity is associated with increased acute toxicity of cytotoxic agents and targeted therapies. We explored whether body composition also influenced the occurrence of early acute limiting toxicity (ALT) of anti-PD1 in melanoma patients. This is a monocentric, retrospective study analyzing toxicity outcome in consecutive melanoma patients treated with nivolumab or pembrolizumab. Various parameters linked to the patient or the disease status have been analysed...
April 10, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28388378/protein-turnover-and-metabolism-in-the-elderly-intensive-care-unit-patient
#5
Stuart M Phillips, Roland N Dickerson, Frederick A Moore, Douglas Paddon-Jones, Peter J M Weijs
Many intensive care unit (ICU) patients do not achieve target protein intakes particularly in the early days following admittance. This period of iatrogenic protein undernutrition contributes to a rapid loss of lean, in particular muscle, mass in the ICU. The loss of muscle in older (aged >60 years) patients in the ICU may be particularly rapid due to a perfect storm of increased catabolic factors, including systemic inflammation, disuse, protein malnutrition, and reduced anabolic stimuli. This loss of muscle mass has marked consequences...
April 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28386715/radiologically-determined-sarcopenia-predicts-morbidity-and-mortality-following-abdominal-surgery-a-systematic-review-and-meta-analysis
#6
REVIEW
Keaton Jones, Alex Gordon-Weeks, Claire Coleman, Michael Silva
BACKGROUND: Individualised risk prediction is crucial if targeted pre-operative risk reduction strategies are to be deployed effectively. Radiologically determined sarcopenia has been shown to predict outcomes across a range of intra-abdominal pathologies. Access to pre-operative cross-sectional imaging has resulted in a number of studies investigating the predictive value of radiologically assessed sarcopenia over recent years. This systematic review and meta-analysis aimed to determine whether radiologically determined sarcopenia predicts post-operative morbidity and mortality following abdominal surgery...
April 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28379719/a-simple-anthropometric-tool-for-the-assessment-of-pre-sarcopenia-in-postmenopausal-women
#7
M E Morosano, I M Menoyo, M F Tomat, A M Masoni, S M Pezzotto
OBJECTIVES: The purpose of this research was to explore the performance of anthropometric tools in the assessment of low muscle mass in a group of postmenopausal women. METHOD: Fifty consecutive ambulatory postmenopausal women were studied. A complete clinical examination and an anthropometric evaluation following a standardized procedure were performed. Three indicators were devised: upper limb adjusted perimeter (ULAP), lower limb adjusted perimeter (LLAP), and appendicular adjusted perimeter (AAP)...
April 5, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28374624/elevated-serum-leptin-levels-are-associated-with-low-vitamin-d-sarcopenic-obesity-poor-muscle-strength-and-physical-performance-in-knee-osteoarthritis
#8
Pacharee Manoy, Wilai Anomasiri, Pongsak Yuktanandana, Aree Tanavalee, Srihatach Ngarmukos, Thanathep Tanpowpong, Sittisak Honsawek
CONTEXT: The associations between serum leptin, vitamin D status, sarcopenic obesity, muscle strength and physical performance in osteoarthritis (OA) remain uncertain. OBJECTIVE: To analyse the relationships between serum leptin, vitamin D status, muscle strength and physical performance in OA patients. METHODS: A total of 208 knee OA patients were enrolled. Serum leptin, vitamin D, muscle strength and physical performance were evaluated. RESULTS: OA patients with sarcopenic obesity had significantly higher serum leptin levels than those with non-sarcopenic obesity...
April 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28371474/muscle-mass-decline-arterial-stiffness-white-matter-hyperintensity-and-cognitive-impairment-japan-shimanami-health-promoting-program-study
#9
Katsuhiko Kohara, Yoko Okada, Masayuki Ochi, Maya Ohara, Tokihisa Nagai, Yasuharu Tabara, Michiya Igase
BACKGROUND: There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to the development of cognitive impairment is unclear. We investigated the possible association between muscle mass decline and cognitive impairment in a cross-sectional study of 1518 subjects aged 55 years or above. We also evaluated arterial stiffness and white matter hyperintensities (WMHs) as possible underlying mechanisms for this association. METHODS: Two sarcopenic indices were measured: thigh muscle cross-sectional area (CSA; calculated by computed tomography) and skeletal muscle mass (bioelectric impedance)...
March 29, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28364311/erratum-to-sarcopenia-and-sarcopenic-obesity-in-comparison-prevalence-metabolic-profile-and-key-differences-a-cross-sectional-study-in-italian-hospitalized-elderly
#10
Simone Perna, Gabriella Peroni, Milena Anna Faliva, Arianna Bartolo, Maurizio Naso, Alessandra Miccono, Mariangela Rondanelli
No abstract text is available yet for this article.
March 31, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28358295/body-adiposity-index-but-not-visceral-adiposity-index-correlates-with-inflammatory-markers-in-sarcopenic-obese-elderly-women
#11
Maurílio Tiradentes Dutra, André Bonadias Gadelha, Otávio Toledo Nóbrega, Ricardo Moreno Lima
Background/Study Context: The association of body adiposity index (BAI) and visceral adiposity index (VAI) with inflammatory markers has yet to be understood. The aim of this work was to investigate the association of BAI and VAI with inflammatory markers in elderly women with sarcopenic obesity (SO). METHODS: A total of 130 women (age: 66.7 ± 5.2 years) underwent body composition analysis by dual-energy x-ray absorptiometry (DEXA). Volunteers were classified according to SO definition...
May 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28346492/dual-energy-x-ray-absorptiometry-body-composition-reference-values-of-limbs-and-trunk-from-nhanes-1999-2004-with-additional-visualization-methods
#12
Benjamin J Hinton, Bo Fan, Bennett K Ng, John A Shepherd
Body Mass Index has traditionally been used as a measure of health, but Fat Mass Index (FMI) and Lean Mass Index (LMI) have been shown to be more predictive of mortality and health risk. Total body FMI and LMI reference curves have particularly been useful in quantifying sarcopenia and sarcopenic obesity. Research has shown regional composition has significant associations to health outcomes. We derived FMI and LMI reference curves of the regions of the body (leg, arm, and trunk) for 15,908 individuals in the 1999-2004 National Health and Nutrition Examination Survey data for each sex and ethnicity using the Lambda-Mu-Sigma (LMS) method and developed software to visualize this regional composition...
2017: PloS One
https://www.readbyqxmd.com/read/28343799/characterization-of-deficits-across-the-spectrum-of-motor-abilities-in-dialysis-patients-and-the-impact-of-sarcopenic-overweight-and-obesity
#13
Maja Bučar Pajek, Jernej Pajek
BACKGROUND & AIMS: Physical performance deficits in kidney failure predict mortality and quality of life. We aimed to quantify deficits in multiple motor abilities, investigate associations of lean and fat tissue content with test results and analyzed performance of sarcopenic individuals with adipose tissue excess. METHODS: Ninety hemodialysis patients and 140 healthy controls performed 6-minute walk test, gait speed measurement, sit-to-stand and time up and go tests, upper extremity handgrip and tapping tests, Stork balance and forward bend flexibility tests...
March 16, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28337365/body-composition-as-a-prognostic-factor-of-neoadjuvant-chemotherapy-toxicity-and-outcome-in-patients-with-locally-advanced-gastric-cancer
#14
Carolina Palmela, Sónia Velho, Lisa Agostinho, Francisco Branco, Marta Santos, Maria Pia Costa Santos, Maria Helena Oliveira, João Strecht, Rui Maio, Marília Cravo, Vickie E Baracos
PURPOSE: Neoadjuvant chemotherapy has been shown to improve survival in locally advanced gastric cancer, but it is associated with significant toxicity. Sarcopenia and sarcopenic obesity have been studied in several types of cancers and have been reported to be associated with higher chemotherapy toxicity and morbi-mortality. The aim of this study was to assess the prevalence of sarcopenia/sarcopenic obesity in patients with gastric cancer, as well as its association with chemotherapy toxicity and long-term outcomes...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28326296/association-between-sarcopenic-obesity-and-metabolic-syndrome-in-postmenopausal-women-a-cross-sectional-study-based-on-the-korean-national-health-and-nutritional-examination-surveys-from-2008-to-2011
#15
Sun-Young Kang, Gyeong Eun Lim, Yang Keun Kim, Hye Won Kim, Kayoung Lee, Tae-Jin Park, Jinseung Kim
BACKGROUND: Menopause contributes to an increase in visceral fat mass and a decrease in muscle protein synthesis. Therefore, we performed this study to examine their relationship how effect the changes of body composition as obesity and sarcopenia on metabolic syndrome (MS) as a predictor of cardiovascular disease in postmenopausal women. METHODS: Using data from the Korean National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011, we estimated that 4,183 postmenopausal women underwent dual energy X-ray absorptiometry scans...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28317484/redox-systems-antioxidants-and-sarcopenia
#16
Bertrand Fougère, Gabor Abellan van Kan, Bruno Vellas, Matteo Cesari
According to the free-radical theory of aging, oxidative stress is a key contributor to the onset of age-related conditions by inducing structural and functional alterations in several cellular components. Although innate defenses exist for limiting the occurrence of such detrimental effects, their ability to counteract the continuous and large production of reactive oxygen species becomes increasingly inefficient with aging. In this context, interventions aimed at preserving the homeostatic balance between oxidant production and antioxidant protection may be beneficial on the pathophysiological modifications and clinical manifestations featuring the aging process...
March 17, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28315175/associations-of-adipose-and-muscle-tissue-parameters-at-colorectal-cancer-diagnosis-with-long-term-health-related-quality-of-life
#17
Eline H van Roekel, Martijn J L Bours, Malou E M Te Molder, José J L Breedveld-Peters, Steven W M Olde Damink, Leo J Schouten, Silvia Sanduleanu, Geerard L Beets, Matty P Weijenberg
PURPOSE: Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2-10 years post-diagnosis...
March 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28295148/reliability-and-minimum-detectable-change-for-common-clinical-physical-function-tests-in-sarcopenic-men-and-women
#18
Nathaniel D M Jenkins, Joel T Cramer
OBJECTIVES: To determine the test-retest reliability and minimum detectable change scores for seven common clinical measurements of muscle strength and physical function in a multiethnic sample of sarcopenic, malnourished men and women. DESIGN: Each participant visited the laboratory seven times over 25 to 26 weeks. Reliability was assessed for each measurement from Familiarization 1 to Familiarization 2 (R1), Familiarization 2 to baseline testing (R2), Familiarization 3 to 12-week testing (R3), and Familiarization 4 to 24-week testing (R4)...
March 15, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28293382/sarcopenia-and-non-alcoholic-fatty-liver-disease-is-there-a-relationship-a-systematic-review
#19
Cristiane V Tovo, Sabrina A Fernandes, Caroline Buss, Angelo A de Mattos
AIM: To perform a systematic review to evaluate the incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) in adult patients with sarcopenia. METHODS: Randomized clinical trials, cross-sectional or cohort studies including adult patients (over 18 years) with sarcopenia were selected. The primary outcomes of interest were the prevalence or incidence of NAFLD in sarcopenic patients. In the screening process, 44 full-text articles were included in the review and 41 studies were excluded...
February 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28291562/consequences-of-sarcopenia-among-nursing-home-residents-at%C3%A2-long-term%C3%A2-follow-up
#20
Tim Henwood, Bothaina Hassan, Paul Swinton, Hugh Senior, Justin Keogh
The consequences of and transition into sarcopenia with long-term survival was investigated in the nursing home setting. Eligible residents from 11 nursing homes were followed-up 18-months after their assessment for sarcopenia using the European Working Group on Sarcopenia in Older People criteria, with other demographic, physical and cognitive health measures collected. Of the 102 older adults who consented at baseline, 22 had died and 58 agreed to participate at follow-up, 51.7% of whom had sarcopenic. Sarcopenia at baseline was associated with a depression (p < ...
March 10, 2017: Geriatric Nursing
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