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https://www.readbyqxmd.com/read/28089364/the-impact-of-neoadjuvant-chemotherapy-on-skeletal-muscle-depletion-and-preoperative-sarcopenia-in-patients-with-resectable-colorectal-liver-metastases
#1
Sam Eriksson, Jan H Nilsson, Peter Strandberg Holka, Jakob Eberhard, Inger Keussen, Christian Sturesson
BACKGROUND: Preoperative skeletal muscle depletion or sarcopenia has been suggested to predict worse outcome after resection of colorectal liver metastases. The aim of the present study was to investigate the impact of neoadjuvant chemotherapy on preoperative skeletal muscle mass prior to liver resection. METHODS: Patients operated with liver resection for colorectal liver metastases between 2010 and 2014 were retrospectively reviewed. Muscle mass was evaluated by measuring muscle area on a cross-sectional computed tomography image at the level of the third lumbar vertebra, and normalized for patient height, presenting a skeletal muscle index...
January 11, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28074267/reduced-serum-myostatin-concentrations-associated-with-genetic-muscle-disease-progression
#2
Peter M Burch, Oksana Pogoryelova, Joe Palandra, Richard Goldstein, Donald Bennett, Lori Fitz, Michela Guglieri, Chiara Marini Bettolo, Volker Straub, Teresinha Evangelista, Hendrik Neubert, Hanns Lochmüller, Carl Morris
Myostatin is a highly conserved protein secreted primarily from skeletal muscle that can potently suppress muscle growth. This ability to regulate skeletal muscle mass has sparked intense interest in the development of anti-myostatin therapies for a wide array of muscle disorders including sarcopenia, cachexia and genetic neuromuscular diseases. While a number of studies have examined the circulating myostatin concentrations in healthy and sarcopenic populations, very little data are available from inherited muscle disease patients...
January 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28072766/the-impact-of-body-composition-parameters-on-ipilimumab-toxicity-and-survival-in-patients-with-metastatic-melanoma
#3
Louise E Daly, Derek G Power, Áine O'Reilly, Paul Donnellan, Samantha J Cushen, Kathleen O'Sullivan, Maria Twomey, David P Woodlock, Henry P Redmond, Aoife M Ryan
BACKGROUND: Body composition is an important predictor of drug toxicity and outcome. Ipilimumab (Ipi), a monoclonal antibody used to treat metastatic melanoma, has specific toxicities. No validated biomarkers that predict Ipi toxicity and efficacy exist. Also, the impact of Ipi on body composition has not been established. METHODS: Patients with metastatic melanoma treated with Ipi between 2009 and 2015 were included. Body composition was assessed by computed tomography at baseline and after four cycles of Ipi...
January 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28061014/a-new-definition-of-sarcopenia-in-patients-with-cirrhosis-undergoing-liver-transplantation
#4
Nicolas Golse, Petru Octav Bucur, Oriana Ciacio, Gabriella Pittau, Antonio Sa Cunha, René Adam, Denis Castaing, Teresa Antonini, Audrey Coilly, Didier Samuel, Daniel Cherqui, Eric Vibert
Although sarcopenia is a common complication of cirrhosis, its diagnosis remains nonconsensual: computed tomography (CT) scan determinations vary and no cutoff values have been established in cirrhotic populations undergoing liver transplantation (LT). Our aim was to compare the accuracy of the most widely used measurement techniques and to establish useful cutoffs in the setting of LT. From the 440 patients transplanted between January 2008 and May 2011 in our tertiary center, we selected 256 patients with cirrhosis for whom a recent CT scan was available during the 4 months prior to LT...
November 7, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/28051799/%C3%A2-sarcopenia-predicts-reduced-survival-in-patients-with-hepatocellular-carcinoma-at-first-diagnosis
#5
Paola Begini, Elia Gigante, Giulio Antonelli, Francesco Carbonetti, Elsa Iannicelli, Giulia Anania, Barbara Imperatrice, Adriano Maria Pellicelli, Gianfranco Delle Fave, Massimo Marignani
:  Background. Sarcopenia is a complication and independent risk factor for mortality in patients with liver cirrhosis. AIM: To assess the prevalence and influence of sarcopenia on overall survival in a cohort of cirrhotic patients with hepatocellular carcinoma managed in a tertiary center. MATERIAL AND METHODS: Abdominal computed tomography of 92 consecutive hepatocellular carcinoma cirrhotic patients, enrolled and followed from 2004 to 2014, were retrospectively studied with a software analyzing the cross-sectional areas of muscles at third lumbar vertebra level...
January 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28049443/performance-of-edmonton-frail-scale-on-frailty-assessment-its-association-with-multi-dimensional-geriatric-conditions-assessed-with-specific-screening-tools
#6
Simone Perna, Matthew D'Arcy Francis, Chiara Bologna, Francesca Moncaglieri, Antonella Riva, Paolo Morazzoni, Pietro Allegrini, Antonio Isu, Beatrice Vigo, Fabio Guerriero, Mariangela Rondanelli
BACKGROUND: The aim of this study was to evaluate the performance of Edmonton Frail Scale (EFS) on frailty assessment in association with multi-dimensional conditions assessed with specific screening tools and to explore the prevalence of frailty by gender. METHODS: We enrolled 366 hospitalised patients (women\men: 251\115), mean age 81.5 years. The EFS was given to the patients to evaluate their frailty. Then we collected data concerning cognitive status through Mini-Mental State Examination (MMSE), health status (evaluated with the number of diseases), functional independence (Barthel Index and Activities Daily Living; BI, ADL, IADL), use of drugs (counting of drugs taken every day), Mini Nutritional Assessment (MNA), Geriatric Depression Scale (GDS), Skeletal Muscle Index of sarcopenia (SMI), osteoporosis and functionality (Handgrip strength)...
January 4, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28041587/inflammation-and-sarcopenia-a-systematic-review-and-meta-analysis
#7
REVIEW
Giulia Bano, Caterina Trevisan, Sara Carraro, Marco Solmi, Claudio Luchini, Brendon Stubbs, Enzo Manzato, Giuseppe Sergi, Nicola Veronese
Inflammatory cytokines have been shown to prompt muscle wasting, ultimately stimulating protein catabolism and suppressing muscle synthesis. However, the possible association between inflammatory parameters and sarcopenia is poorly understood. We therefore aimed to summarize the current evidence about this topic with a meta-analysis of studies reporting serum inflammatory parameters in patients with sarcopenia vs. people without sarcopenia (controls). An electronic PubMed and Scopus search through to 09/01/2016 and meta-analysis of cross-sectional studies comparing serum levels of inflammatory cytokines between patients with sarcopenia and controls was made, calculating random-effects standardized mean differences (SMDs) ±95% confidence intervals (CIs) as the effect size...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28032232/effectiveness-of-a-preoperative-exercise-and-nutritional-support-program-for-elderly-sarcopenic-patients-with-gastric-cancer
#8
Kazuyoshi Yamamoto, Yukiko Nagatsuma, Yasunari Fukuda, Motohiro Hirao, Kazuhiro Nishikawa, Atsushi Miyamoto, Masataka Ikeda, Shoji Nakamori, Mitsugu Sekimoto, Kazumasa Fujitani, Toshimasa Tsujinaka
We established a preoperative exercise and nutritional support program for elderly sarcopenic patients with gastric cancer. Twenty-two gastric cancer patients aged 65 years or older with a diagnosis of sarcopenia according to the algorithm proposed by the European Working Group on Sarcopenia in Older People received our preoperative program. The median duration of the program participation was 16 days. Total calorie and protein intakes were significantly higher after the program than before [29.4 ± 6.9 kcal/kg ideal body weight (IBW) vs 27...
December 28, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/28031974/physical-activity-and-sarcopenic-obesity-definition-assessment-prevalence-and-mechanism
#9
REVIEW
Duck-Chul Lee, Robin P Shook, Clemens Drenowatz, Steven N Blair
Sarcopenic obesity is the coexistance of sarcopenia and obesity. Modern sarcopenia definition includes low muscle mass, weak muscle strength (handgrip strength) and poor physical function (slow walking), although the clinical definition of each varies worldwide. The cut-points for low muscle mass for men and women using appendicular lean mass divided by height (kg/m(2)) are ≤7.0 and ≤5.4 in Asians, and ≤7.23 and ≤5.67 in Caucasians, respectively. The cut-points for weak handgrip strength (kg) for men and women are <26 and <18 in Asians, and <30 and <20 in Caucasians, respectively...
September 2016: Future Science OA
https://www.readbyqxmd.com/read/28029078/nutrition-and-exercise-in-sarcopenia
#10
Stephen D Anton, Azumi Hida, Robert Mankowski, Andrew Layne, Lawrence Solberg, Arch G Mainous, Thomas W Buford
Sarcopenia is a debilitating condition that involves loss of muscle mass and function, which affects virtually everyone as they age, and can lead to frailty and ultimately disability. In growing recognition of the importance of both muscle strength and muscle mass relative to body size in contributing to functional decline, recent definitions have now incorporated grip strength and a correction for body mass as part of the key criteria that define sarcopenia. With this new definition, a much larger population of older adults are now at risk of sarcopenia...
December 27, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28024944/impact-of-sarcopenia-on-outcome-in-patients-with-esophageal-resection-following-neoadjuvant-chemotherapy-for-esophageal-cancer
#11
M Paireder, R Asari, I Kristo, E Rieder, D Tamandl, A Ba-Ssalamah, S F Schoppmann
BACKGROUND: Nutritional status and body composition parameters such as sarcopenia are important risk factors for impaired outcome in patients with esophageal cancer. This study was conducted to evaluate the effect of sarcopenia on long-term outcome after esophageal resection following neoadjuvant treatment. METHODS: Skeletal muscle index (SMI) and body composition parameters were measured in patients receiving neoadjuvant treatment for locally advanced esophageal cancer...
December 14, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28012805/clinical-implications-of-sarcopenia-on-decreased-bone-density-in-men-with-chronic-obstructive-pulmonary-disease
#12
Ji An Hwang, Young Sam Kim, Ah Young Leem, Moo Suk Park, Se Kyu Kim, Joon Chang, Ji Ye Jung
BACKGROUND: Sarcopenia and osteoporosis are systemic features of chronic obstructive pulmonary disease (COPD). The present study investigated the association between sarcopenia and osteopenia/osteoporosis, and the factors associated with low bone mineral density (BMD) in men with COPD. METHODS: Data of 777 men with COPD who underwent both pulmonary function test and dual energy X-ray absorptiometry were extracted from the Korean National Health and Nutritional Examination Survey database between 2008 and 2011...
December 21, 2016: Chest
https://www.readbyqxmd.com/read/28012107/the-future-prevalence-of-sarcopenia-in-europe-a-claim-for-public-health-action
#13
O Ethgen, C Beaudart, F Buckinx, O Bruyère, J Y Reginster
Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected burden of sarcopenia in the coming years. Age- and gender-specific population projections were retrieved until 2045 from the Eurostat online database (28 European countries). Age- and gender-specific prevalences of sarcopenia were interpolated from a study that compared prevalence estimates according to the different diagnostic cutoffs of the EWGSOP proposed definition...
December 24, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/28004299/evaluation-of-sarcopenia-in-patients-with-distal-radius-fractures
#14
Young Hak Roh, Young Do Koh, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
: Sarcopenia is more prevalent in patients with distal radius fracture (DRF) than in age- and sex-matched controls. Lower appendicular mass index in men and weaker grip strength in both men and women increase the likelihood of DRF. INTRODUCTION: Sarcopenia is a core component of physical frailty that predisposes older people to falls and negatively impacts the activities of daily living. The objectives of this study were to compare the prevalence of sarcopenia in patients with DRF with that in age- and sex-matched controls without DRF; and evaluate the association between sarcopenia and the occurrence of DRF...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27957783/russian-caucasians-have-a-higher-risk-of-erosive-reflux-disease-compared-with-east-asians-a-direct-endoscopic-comparison
#15
S-H Ko, M K Baeg, H S Jung, P Kim, M-G Choi
BACKGROUND: Erosive reflux disease (ERD) is prevalent in the West, and its incidence is increasing in the East. The differences between the West and East, especially in body composition, have not been investigated thoroughly. METHODS: Subjects who underwent esophagogastroduodenoscopy and body composition analysis during health screening were analyzed retrospectively. Russian Caucasians who visited Korea were propensity matched with native Koreans. Endoscopy results were analyzed to identify ERD and gastroesophageal flap valve (GEFV) status...
December 12, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27932368/longitudinal-associations-between-body-composition-sarcopenic-obesity-and-outcomes-of-frailty-disability-institutionalisation-and-mortality-in-community-dwelling-older-men-the-concord-health-and-ageing-in-men-project
#16
Vasant Hirani, Vasi Naganathan, Fiona Blyth, David G Le Couteur, Markus J Seibel, Louise M Waite, David J Handelsman, Robert G Cumming
BACKGROUND: to explore the longitudinal associations between body composition measures, sarcopenic obesity and outcomes of frailty, activities of daily living (ADL) and instrumental ADL (IADL) disability, institutionalisation and mortality. METHODS: men aged ≥ 70 years (2005-07) from the Concord Health and Ageing in Men Project were assessed at baseline (n = 1,705), 2 (n = 1,366) and 5 years (n = 954). The main outcome measures were frailty (adapted Fried criteria), ADL, including personal care and mobility and IADL disability (ability to perform tasks for independent living), institutionalisation and mortality...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27920508/impact-of-whole-body-electromyostimulation-on-cardiometabolic-risk-factors-in-older-women-with-sarcopenic-obesity-the-randomized-controlled-formosa-sarcopenic-obesity-study
#17
Katharina Wittmann, Cornel Sieber, Simon von Stengel, Matthias Kohl, Ellen Freiberger, Franz Jakob, Michael Lell, Klaus Engelke, Wolfgang Kemmler
BACKGROUND: Sarcopenic obesity (SO) is characterized by a combination of low muscle and high fat mass with an additive negative effect of both conditions on cardiometabolic risk. The aim of the study was to determine the effect of whole-body electromyostimulation (WB-EMS) on the metabolic syndrome (MetS) in community-dwelling women aged ≥70 years with SO. METHODS: The study was conducted in an ambulatory university setting. Seventy-five community-dwelling women aged ≥70 years with SO living in Northern Bavaria, Germany, were randomly allocated to either 6 months of WB-EMS application with (WB-EMS&P) or without (WB-EMS) dietary supplementation (150 kcal/day, 56% protein) or a non-training control group (CG)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27903148/obesity-and-energy-balance-in-gi-cancer
#18
Justin C Brown, Jeffrey A Meyerhardt
The prevalence of overweight (body mass index [BMI], 25 to 29.9 kg/m(2)) and obesity (BMI ≥ 30 kg/m(2)) have increased dramatically in the United States. Because increasing BMI is associated with the development of multiple different cancer types, including most GI cancers, providers will frequently encounter patients with GI cancer who are overweight or obese. Mounting evidence associates overweight and/or obesity with worsened prognosis in multiple GI cancers, including esophageal, gastric, hepatocellular, pancreatic, and colorectal...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27900103/muscle-wasting-associated-with-the-long-term-use-of-mtor-inhibitors
#19
Bishal Gyawali, Tomoya Shimokata, Kazunori Honda, Chihiro Kondoh, Naomi Hayashi, Yasushi Yoshino, Naoto Sassa, Yasuyuki Nakano, Momokazu Gotoh, Yuichi Ando
Some targeted therapies alter muscle mass due to interference with pathways of muscle metabolism. The effects of mammalian target of ra pamycin (mTOR) inhibitors on muscle mass have yet to be fully elucidated. In the present study, the computerized tomography (CT) scans of patients receiving mTOR inhibitors for at least 6 months taken at baseline and post-therapy were retrospectively retrieved, and body composition analyses were performed using the software, sliceOmatic version 5.0 (TomoVision, Inc., Magog, QC, Canada)...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27897430/validation-of-the-sarqol%C3%A2-a-specific-health-related-quality-of-life-questionnaire-for-sarcopenia
#20
Charlotte Beaudart, Emmanuel Biver, Jean-Yves Reginster, René Rizzoli, Yves Rolland, Ivan Bautmans, Jean Petermans, Sophie Gillain, Fanny Buckinx, Nadia Dardenne, Olivier Bruyère
BACKGROUND: A specific self-administrated health-related quality of life questionnaire for sarcopenia, the Sarcopenia and Quality Of Life (SarQoL®), has been recently developed. This questionnaire is composed of 55 items translated into 22 questions and organized into seven domains of quality of life. The objective of the present work is to evaluate the psychometric properties (discriminative power, validity, reliability, floor and ceiling effects) of the SarQoL® questionnaire. METHODS: Sarcopenic subjects were recruited in an outpatient clinic in Liège, Belgium and were diagnosed according to the algorithm developed by the European Working Group on Sarcopenia in Older People...
October 22, 2016: Journal of Cachexia, Sarcopenia and Muscle
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