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Maude Dulac, Guy El Hajj Boutros, Charlotte Pion, Sébastien Barbat-Artigas, Gilles Gouspillou, Mylène Aubertin-Leheudre
Objective: To investigate whether handgrip strength normalized to body weight could be a useful clinical tool to identify dynapenia and assess functional capacity in post-menopausal women. Method: A total of 136 postmenopausal women were recruited. Body composition (Dual Energy X-ray Absorptiometry [DEXA], Bio-electrical Impedence Analysis [BIA]), grip strength (dynamometer) and functional capacity (senior fitness tests) were evaluated. Dynapenia was established according to a handgrip strength index (handgrip strength divided by body weight (BW) in Kg/KgBW) obtained from a reference population of young women: Type I dynapenic (<0...
September 15, 2016: Brazilian Journal of Physical Therapy
Todd M Manini, Brian C Clark
No abstract text is available yet for this article.
September 2016: Journal of Cachexia, Sarcopenia and Muscle
W Kyle Mitchell, Daniel J Wilkinson, Bethan E Phillips, Jonathan N Lund, Kenneth Smith, Philip J Atherton
Healthy individuals maintain remarkably constant skeletal muscle mass across much of adult life, suggesting the existence of robust homeostatic mechanisms. Muscle exists in dynamic equilibrium whereby the influx of amino acids (AAs) and the resulting increases in muscle protein synthesis (MPS) associated with the intake of dietary proteins cancel out the efflux of AAs from muscle protein breakdown that occurs between meals. Dysregulated proteostasis is evident with aging, especially beyond the sixth decade of life...
July 2016: Advances in Nutrition
Scott C Adams, Roanne J Segal, Donald C McKenzie, James R Vallerand, Andria R Morielli, John R Mackey, Karen Gelmon, Christine M Friedenreich, Robert D Reid, Kerry S Courneya
The purpose of this study was to conduct an exploratory analysis of the START examining the effects of resistance exercise training (RET) and aerobic exercise training (AET) on sarcopenia, dynapenia, and associated quality of life (QoL) changes in breast cancer (BC) patients receiving adjuvant chemotherapy. Participants were randomized to usual care (UC) (n = 70), AET (n = 64), or RET (n = 66) for the duration of chemotherapy. Measures of sarcopenia [skeletal muscle index (SMI)] and dynapenia [upper extremity (UE) and lower extremity (LE) muscle dysfunction (MD)] were normalized relative to age-/sex-based clinical cut-points...
August 2016: Breast Cancer Research and Treatment
André de Camargo Smolarek, Luis Henrique Boiko Ferreira, Luis Paulo Gomes Mascarenhas, Steven R McAnulty, Karla Daniele Varela, Mônica C Dangui, Marcelo Paes de Barros, Alan C Utter, Tácito P Souza-Junior
Aging is a degenerative process marked by recognized functional, physiological, and metabolic impairments, such as dynapenia and diminished cognitive capacity. Therefore, the search for innovative strategies to prevent/delay these physiological and cognitive disorders is essential to guarantee the independence and life quality of an elderly population. The aim of this work is to verify the effect of a 12-week resistance exercise program on the general physical aptitude and cognitive capacities of elderly and sedentary women...
2016: Clinical Interventions in Aging
Michela Barichella, Giovanna Pinelli, Laura Iorio, Erica Cassani, Angela Valentino, Chiara Pusani, Valentina Ferri, Carlotta Bolliri, Marianna Pasqua, Gianni Pezzoli, Giuseppe Frazzitta, Emanuele Cereda
OBJECTIVES: To estimate prevalence of sarcopenia and dynapenia in outpatients with Parkinson disease (PD) and to investigate their association with the features of the disease. DESIGN: Cross-sectional study. SETTING: A specialized tertiary care center. PARTICIPANTS: Consecutive patients (n = 364) aged 65 years or older, affected by parkinsonian syndromes. MEASUREMENTS: Skeletal muscle mass (SMM), as well as strength and gait speed (GS) were assessed by bioimpedence analysis, handgrip dynamometry, and the 4-meter walking test, respectively...
July 1, 2016: Journal of the American Medical Directors Association
Timothy D Law, Leatha A Clark, Brian C Clark
For well over twenty centuries the muscle wasting (sarcopenia) and weakness (dynapenia) that occurs with old age has been a predominant concern of mankind. Exercise has long been suggested as a treatment to combat sarcopenia and dynapenia, as it exerts effects on both the nervous and muscular systems that are critical to positive physiological and functional adaptations (e.g., enhanced muscle strength). For more than two decades scientists have recognized the profound role that progressive resistance exercise training can have on increasing muscle strength, muscle size and functional capacity in older adults...
2016: Annual Review of Gerontology & Geriatrics
David Scott, Sahan D Chandrasekara, Laura L Laslett, Flavia Cicuttini, Peter R Ebeling, Graeme Jones
The purpose of this study is to determine whether low muscle mass (sarcopenia) or strength (dynapenia), in the presence of obesity, are associated with increased risk for osteoporosis and non-vertebral fracture over 5-10 years in community-dwelling older adults. N = 1089 volunteers (mean ± SD age 62 ± 7 years; 51 % female) participated at baseline and 761 attended follow-up clinics (mean 5.1 ± 0.5 years later). Total body, total hip and spine BMD, and appendicular lean and total fat mass were assessed by DXA...
July 2016: Calcified Tissue International
Doris Eglseer, Ruth Poglitsch, Regina Elisabeth Roller-Wirnsberger
Sarcopenia, as defined by the European working group on sarcopenia in older people (EWGSOP), is a highly prevalent syndrome characterized by age-related loss of muscle mass and muscle strength/power with impacts on physical function, health and quality of life in older people. The complex, multifaceted and still not completely elucidated etiology of sarcopenia and loss of muscle function (dynapenia) poses challenges for the design of interventional studies to combat loss of muscle strength. Several factors, however, have been demonstrated to have major impacts for maintenance of physiological muscle functioning, including nutrition and in particular specific nutrients...
February 2016: Zeitschrift Für Gerontologie und Geriatrie
Ana V Asaduroglu, M Tablada, J Cosiansi Bai, M Carrillo, M Canale, R Gallerano
UNLABELLED: Aging produces body changes such as redistribution of fat and loss of muscle mass and strength, predisposing to fragility, functional impairment and disability. OBJECTIVE: To analyze the relationship between body profile and physical and cognitive function by age in in ambulatory elderly women from the city of Córdoba. METHODS: 178 healthy older women (OW) ≥60 years free living were evaluated attending centers of retirees and day homes in the city of Córdoba...
2015: Revista de la Facultad de Ciencias Médicas
D J Cuthbertson, J A Bell, S Y Ng, G J Kemp, M Kivimaki, M Hamer
AIM: Obesity is a well-established risk factor for developing Type 2 diabetes. Evidence suggests that sarcopenia, the age-related decline in muscle mass and strength, may exacerbate diabetes risk in obese individuals. The aim of this study was to determine the combined effect of obesity and low muscle strength, dynapenia, on the risk of incident Type 2 diabetes in older adults. METHODS: Participants were 5953 (1670 obese) men and women from the English Longitudinal Study of Ageing without known Type 2 diabetes at baseline and for whom handgrip strength, biochemical and other clinical data were collected...
August 2016: Diabetic Medicine: a Journal of the British Diabetic Association
John A Batsis, Alicia J Zbehlik, Dawna Pidgeon, Stephen J Bartels
BACKGROUND: Obesity is associated with functional impairment, institutionalization, and increased mortality risk in elders. Dynapenia is defined as reduced muscle strength and is a known independent predictor of adverse events and disability. The synergy between dynapenia and obesity leads to worse outcomes than either independently. We identified the impact of dynapenic obesity in a cohort at risk for and with knee osteoarthritis on function. METHODS: We identified adults aged ≥ 60 years from the Osteoarthritis Initiative...
October 8, 2015: BMC Geriatrics
Ryoko Kawakami, Susumu S Sawada, I-Min Lee, Munehiro Matsushita, Yuko Gando, Takashi Okamoto, Koji Tsukamoto, Mitsuru Higuchi, Motohiko Miyachi, Steven N Blair
BACKGROUND: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear. METHODS: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 years. Weight and height were measured, and overweight/obesity was defined as a body mass index ≥25 kg/m(2). The prevalence of type 2 diabetes, defined as fasting plasma glucose ≥126 mg/dL and/or hemoglobin A1c ≥6...
2015: Journal of Epidemiology
Kathryn N Porter Starr, Connie W Bales
The health challenges prompted by obesity in the older adult population are poorly recognized and understudied. A defined treatment of geriatric obesity is difficult to establish, as it must take into account biological heterogeneity, age-related comorbidities, and functional limitations (sarcopenia/dynapenia). This retrospective article highlights the current understanding of the optimal body mass index (BMI) in later life, addressing appropriate recommendations based on BMI category, age, and health history...
August 2015: Clinics in Geriatric Medicine
Stuart M Phillips
Age-related sarcopenia, composed of myopenia (a decline in muscle mass) and dynapenia (a decline in muscle strength), can compromise physical function, increase risk of disability, and lower quality of life in older adults. There are no available pharmaceutical treatments for this condition, but evidence shows resistance training (RT) is a viable and relatively low-cost treatment with an exceptionally positive side effect profile. Further evidence suggests that RT-induced increases in muscle mass, strength, and function can be enhanced by certain foods, nutrients, or nutritional supplements...
July 2015: Advances in Nutrition
Chung-Yu Huang, An-Chun Hwang, Li-Kuo Liu, Wei-Ju Lee, Liang-Yu Chen, Li-Ning Peng, Ming-Hsien Lin, Liang-Kung Chen
A decline in physical and/or cognitive function is a common feature of aging, and frailty has been shown to be associated with cognitive impairment and dementia. This study aimed to evaluate the association between dynapenia, sarcopenia, and cognitive impairment among community-dwelling older people in Taiwan. Data from the I-Lan Longitudinal Aging Study (ILAS) were retrieved for study. Global cognitive function was assessed by Mini-Mental State Examination (MMSE), whereas the Chinese Version Verbal Learning Test, Boston Naming Test, Verbal Fluency Test, Taylor Complex Figure Test, Digits Backward Test, and Clock Drawing Test were used to assess different domains of cognitive function...
February 2016: Rejuvenation Research
David Scott, Robin M Daly, Kerrie M Sanders, Peter R Ebeling
Due to their differing etiologies and consequences, it has been proposed that the term "sarcopenia" should revert to its original definition of age-related muscle mass declines, with a separate term, "dynapenia", describing muscle strength and function declines. There is increasing interest in the interactions of sarcopenia and dynapenia with obesity. Despite an apparent protective effect of obesity on fracture, increased adiposity may compromise bone health, and the presence of sarcopenia and/or dynapenia ("sarcopenic obesity" and "dynapenic obesity") may exacerbate the risk of falls and fracture in obese older adults...
August 2015: Current Osteoporosis Reports
Richard Salcido
No abstract text is available yet for this article.
April 2015: Advances in Skin & Wound Care
Pedro Ángel Latorre-Román, Víctor Segura-Jiménez, Virginia A Aparicio, María Aparecida Santos E Campos, Felipe García-Pinillos, Manuel Herrador-Colmenero, Inmaculada C Álvarez-Gallardo, Manuel Delgado-Fernández
Fibromyalgia is associated with physical disabilities in daily activities. Moreover, patients with fibromyalgia present similar levels of functional capacity and physical condition than elderly people. The aim of this study was to analyse the evolution of strength and muscle mass in women with fibromyalgia along ageing. A total sample of 492 fibromyalgia patients and 279 healthy control women were included in the study. Participants in each group were further divided into four age subgroups: subgroup 1: 30-39 years old, subgroup 2: 40-49 years old, subgroup 3: 50-59 years old and subgroup 4: 60-69 years old...
July 2015: Rheumatology International
Tae Nyun Kim, Kyung Mook Choi
The important changes in body composition associated with aging are a decline in skeletal muscle mass and an increase in body fat. Body fat distribution also changes with age; subcutaneous fat decreases and visceral abdominal fat increase, which contributes to numerous cardiometabolic diseases (CMDs) such as type 2 diabetes, dyslipidemia, and cardiovascular disease (CVD). Sarcopenia often accompanied by an increase in body fat and vice versa, a scenario termed sarcopenic obesity (SO), which might lead to the cumulative risk of both sarcopenia and obesity...
July 2015: Journal of Cellular Biochemistry
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