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Dynapenia

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https://www.readbyqxmd.com/read/29904611/urinary-diagnostic-proteomic-markers-for-dynapenia-in-cancer-patients
#1
Holger Husi, Alisdair MacDonald, Richard J E Skipworth, Janice Miller, Andrew Cronshaw, Carolyn Greig, Kenneth C H Fearon, James A Ross
Dynapenia is defined as the age-related loss of muscle strength, and plays a significant role in the loss of physical function and increased risk of disability among older individuals. The need for an early diagnosis supports the search for a biomarker that reflects muscle 'weakening'. This has previously proven difficult due to patient heterogeneity at presentation and lack of understanding of the underlying molecular mechanisms. The aim of the present study was to identify potential urinary biomarkers of dynapenia in patients undergoing potentially curative surgery for upper gastrointestinal cancer...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29872161/association-between-hospitalization-related-outcomes-dynapenia-and-body-mass-index-the-glisten-study
#2
Andrea P Rossi, Francesco Fantin, Pasquale Abete, Giuseppe Bellelli, Mario Bo, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Giovanna Maria Manca, Maria Rosaria Rizzo, Lara Bianchi, Francesco Landi, Stefano Volpato
OBJECTIVE: To compare the prognostic value of dynapenia, as evaluated by handgrip, and body mass index (BMI) on length of stay (LOS), days of bed rest, and other hospitalization-related outcomes in a population of older adults admitted to 12 italian acute care divisions. METHODS: Data on age, weight, BMI, comorbidities, ADL, physical activity level, muscle strength, were recorded at hospital admission. LOS, days of bed rest, intrahospital falls, and discharge destination were also recorded during the hospitalization...
June 5, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29752635/incidence-of-sarcopenia-and-dynapenia-according-to-stage-in-patients-with-idiopathic-parkinson-s-disease
#3
Tamer Yazar, Hülya Olgun Yazar, Emel Zayimoğlu, Soner Çankaya
AIM: In this study, the aim was to identify the incidence of sarcopenia and dynapenia according to disease stage among idiopathic Parkinson's disease (IPD) patients and collect data to illuminate precautions related to reducing the disease load. METHOD: The study was completed with 166 patients divided by stage according to modified Hoehn and Yahr (HYR) criteria and 249 healthy volunteers aged from 18 to 39 and 68 to 75 years met the inclusion criteria. In our prospective and cross-sectional study, patients with IPD according to "UK Brain Bank" diagnostic criteria had the Unified Parkinson's Disease Rating Scale (UPDRS) and HYR scales applied...
May 12, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29751507/effects-of-whey-protein-supplementation-pre-or-post-resistance-training-on-muscle-mass-muscular-strength-and-functional-capacity-in-pre-conditioned-older-women-a-randomized-clinical-trial
#4
Hellen C G Nabuco, Crisieli M Tomeleri, Paulo Sugihara Junior, Rodrigo R Fernandes, Edilaine F Cavalcante, Melissa Antunes, Alex S Ribeiro, Denilson C Teixeira, Analiza M Silva, Luís B Sardinha, Edilson S Cyrino
Aging is associated with sarcopenia and dynapenia, with both processes contributing to functional dependence and mortality in older adults. Resistance training (RT) and increased protein intake are strategies that may contribute to health improvements in older adults. Therefore, the aim was to investigate the effects of whey protein (WP) supplementation consumed either immediately pre- or post-RT on skeletal muscle mass (SMM), muscular strength, and functional capacity in pre-conditioned older women. Seventy older women participated in this investigation and were randomly assigned to one of three groups: whey protein pre-RT and placebo post-RT (WP-PLA, n = 24), placebo pre-RT and whey protein post-RT (PLA-WP, n = 23), and placebo pre- and post-RT (PLA-PLA, n = 23)...
May 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29734464/low-muscle-strength-and-mass-is-associated-with-the-accelerated-decline-of-bone-microarchitecture-at-the-distal-radius-in-older-men-the-prospective-strambo-study
#5
Philippe Wagner, Roland Chapurlat, René Ecochard, Pawel Szulc
Low muscle mass and strength are associated with poor bone microarchitecture. We studied the association of muscle mass and strength with changes in bone microarchitecture of distal radius in 821 older men during an 8-year prospective follow-up. Bone microarchitecture was assessed by high resolution peripheral quantitative computed tomography (XtremeCT-1, Scanco) at baseline, then after 4 and 8 years. Relative appendicular lean mass of the upper limbs (RALM-u.l.) was calculated as DXA-measured lean mass of upper limbs divided by (height)2 ...
May 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29656012/muscle-strength-and-size-are-associated-with-motor-unit-connectivity-in-aged-mice
#6
Kajri A Sheth, Chitra C Iyer, Christopher G Wier, Alexander E Crum, Anna Bratasz, Stephen J Kolb, Brian C Clark, Arthur H M Burghes, W David Arnold
In older adults, the loss of muscle strength (dynapenia) and the loss of muscle mass (sarcopenia) are important contributors to the loss of physical function. We sought to investigate dynapenia, sarcopenia, and the loss of motor unit function in aging mice. C57BL/6J mice were analyzed with cross-sectional (males: 3 vs. 27 months; males and females: 8 vs. 12 vs. 20 months) and longitudinal studies (males: 10-25 months) using in vivo electrophysiological measures of motor unit connectivity (triceps surae compound muscle action potential and motor unit number estimation), in vivo measures of plantar flexion torque, magnetic resonance imaging of hind limb muscle volume, and grip strength...
July 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29644921/cognitive-frailty-and-its-association-with-all-cause-mortality-among-community-dwelling-older-adults-in-taiwan-results-from-i-lan-longitudinal-aging-study
#7
Li-Kuo Liu, Wei-Ju Lee, Yi-Hui Wu, An-Chun Hwang, Ming-Hsien Lin, Hiroyuki Shimada, Li-Ning Peng, Ching-Hui Loh, Hidenori Arai, Liang-Kung Chen
BACKGROUND: The definition of cognitive frailty and its prediction for adverse outcome of community-living older adults remains controversial. This study aims to evaluate the association between cognitive frailty and all-cause mortality among community-living older adults. METHODS: Data of the I-Lan Longitudinal Aging Study (ILAS) were retrieved for study. Frailty was defined by Fried's criteria, and a series of neuropsychological assessments, including the Mini-Mental State Examination (MMSE), Center for Epidemiology Studies-Depression (CES-D), the delay free recall in the Chinese Version Verbal Learning Test, the Boston Naming Test, the category (animal) Verbal Fluency Test, the Taylor Complex Figure Test, the digital backward and the Clock Drawing Test were performed...
April 12, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29627421/depressive-symptoms-and-muscle-weakness-a-two-way-relation
#8
Marco Bertoni, Stefania Maggi, Enzo Manzato, Nicola Veronese, Guglielmo Weber
The potential association between depressive symptoms and dynapenia - i.e. muscle weakness - is limited to few, mainly cross-sectional, studies. We use SHARE (Survey on Health, Ageing and Retirement in Europe) panel data to investigate whether the onset of dynapenia at 4-year follow-up can be explained by pre-existing (either at baseline, or at 2-year follow-up) depressive symptoms, or vice versa. Depressive symptoms were identified as a score of 4 or more on the 12-item EURO-D scale. Individuals were classified as affected by dynapenia if they had handgrip strength of <20 kg for women and 30 kg for men...
April 5, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29604401/limb-muscle-quality-and-quantity-in-elderly-adults-with-dynapenia-but-not-sarcopenia-an-ultrasound-imaging-study
#9
Ke-Vin Chang, Wei-Ting Wu, Kuo-Chin Huang, Wei Han Jan, Der-Sheng Han
BACKGROUND: Dynapenia is prevalent in people with reduced skeletal muscle mass, i.e. sarcopenia, but a certain population develops muscle strength loss despite having normal skeletal muscle volume. To date, studies investigating muscle quality and quantity in groups with dynapenia but not sarcopenia are limited. METHODS: Echogenicity and thickness of the biceps brachii, triceps brachii, rectus femoris, and medial gastrocnemius muscles were measured using high-resolution ultrasonography in 140 community-dwelling elderly adults...
March 28, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29531601/dynapenia-and-sarcopenia-as-a-risk-factor-for-disability-in-a-falls-and-fractures-clinic-in-older-persons
#10
Angela-María Benjumea, Carmen-Lucía Curcio, Gustavo Duque, Fernando Gómez
BACKGROUND: The role of sarcopenia and dynapenia in disability in older persons from falls and bone health clinics remain unknown. AIM: This study aims to compare the association of sarcopenia and dynapenia with physical and instrumental disability in a population of older persons attending a falls and fractures clinic. METHODS: This is a cross-sectional study in Manizales, Andes Mountains, Colombia. A cohort of 534 subjects (mean age = 74, 75% female) Sarcopenia was measured according to the European Working Group on Sarcopenia in Older People (EWGSOP) including an index of skeletal mass, muscle strength, and gait speed...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29476104/exploring-the-link-between-serum-phosphate-levels-and-low-muscle-strength-dynapenia-and-sarcopenia
#11
Yuan-Yuei Chen, Tung-Wei Kao, Cheng-Wai Chou, Chen-Jung Wu, Hui-Fang Yang, Ching-Huang Lai, Li-Wei Wu, Wei-Liang Chen
Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrition Examination Survey, a total of 7421 participants aged 20 years or older were included in our study with comprehensive examinations included anthropometric parameters, strength of the quadriceps muscle, and appendicular lean masses...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421778/prevalence-of-sarcopenia-and-dynapenia-and-their-determinants-in-iranian-peritoneal-dialysis-patients
#12
Atefeh As'habi, Iraj Najafi, Hadi Tabibi, Mehdi Hedayati
INTRODUCTION: Uremic sarcopenia and dynapenia are prevalent in chronic kidney disease patients, including dialysis patients. The present study was designed to determine the prevalence of sarcopenia and dynapenia and their determinants in peritoneal dialysis (PD) patients in Tehran, Iran. MATERIALS AND METHODS: All eligible PD patients at the peritoneal dialysis centers of Tehran were included in this cross-sectional study. Skeletal muscle mass and muscle strength were assessed using bioelectrical impedance analysis and hand grip strength, respectively...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29368427/physical-activity-unveils-the-relationship-between-mitochondrial-energetics-muscle-quality-and-physical-function-in-older-adults
#13
Giovanna Distefano, Robert A Standley, Xiaolei Zhang, Elvis A Carnero, Fanchao Yi, Heather H Cornnell, Paul M Coen
BACKGROUND: The concept of mitochondrial dysfunction in ageing muscle is highly controversial. In addition, emerging evidence suggests that reduced muscle oxidative capacity and efficiency underlie the aetiology of mobility loss in older adults. Here, we hypothesized that studying well-phenotyped older cohorts across a wide range of physical activity would unveil a range of mitochondrial function in skeletal muscle and in turn allow us to more clearly examine the impact of age per se on mitochondrial energetics...
January 24, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29300433/dynapenic-abdominal-obesity-increases-mortality-risk-among-english-and-brazilian-older-adults-a-10-year-follow-up-of-the-elsa-and-sabe-studies
#14
T da Silva Alexandre, S Scholes, J L Ferreira Santos, Y A de Oliveira Duarte, C de Oliveira
BACKGROUND/OBJECTIVE: There is little epidemiological evidence demonstrating that dynapenic abdominal obesity has higher mortality risk than dynapenia and abdominal obesity alone. Our main aim was to investigate whether dynapenia combined with abdominal obesity increases mortality risk among English and Brazilian older adults over ten-year follow-up. DESIGN: Cohort study. SETTING: United Kingdom and Brazil. PARTICIPANTS: Data came from 4,683 individuals from the English Longitudinal Study of Ageing (ELSA) and 1,490 from the Brazilian Health, Well-being and Aging study (SABE), hence the final sample of this study was 6,173 older adults...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29289723/diaphragm-muscle-dysfunction-in-patients-with-heart-failure
#15
Mari Miyagi, Yoshiharu Kinugasa, Takeshi Sota, Kensaku Yamada, Takuya Ishisugi, Masayuki Hirai, Kiyotaka Yanagihara, Nobuhiko Haruki, Koichi Matsubara, Masahiko Kato, Kazuhiro Yamamoto
BACKGROUND: Inspiratory muscle weakness is associated with the development of exercise intolerance in patients with heart failure (HF). Ultrasound assessment of the diaphragm is used to evaluate respiratory muscle function, but its application in patients with HF remains undefined. We examined the relationship of diaphragm function as assessed by ultrasonography with inspiratory muscle strength and exercise tolerance in HF. METHODS AND RESULTS: Seventy-seven patients hospitalized with HF were enrolled...
April 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29278424/feasibility-of-systematic-handgrip-strength-testing-in-digestive-cancer-patients-treated-with-chemotherapy-the-fightdigo-study
#16
Marie-Amélie Ordan, Camille Mazza, Coralie Barbe, Marine Perrier, Damien Botsen, Yohann Renard, Johanna Moreau, Mathilde Brasseur, Barbara Taillière, Éric Bertin, Olivier Bouché
BACKGROUND: Handgrip strength (HGS) is a widely studied noninvasive test. Weak strength (dynapenia) seems to be associated with high morbidity and mortality in different populations, notably oncology populations. Despite this, HGS testing is not used in daily practice in oncology. The study was aimed at evaluating the feasibility and acceptability of HGS testing in patients with digestive cancer treated with ambulatory chemotherapy. METHODS: In this prospective, single-center study, enrolled patients were followed for 6 months...
April 1, 2018: Cancer
https://www.readbyqxmd.com/read/29212996/-a-comparison-of-the-associations-of-dynapenia-and-sarcopenia-with-fear-of-falling-in-elderly-diabetic-patients
#17
Satoshi Ida, Kazuya Murata, Yuki Ishihara, Kanako Imataka, Ryutaro Kaneko, Ryoko Fujiwara, Hiroka Takahashi
AIM: To comparatively investigate whether dynapenia and sarcopenia, as defined by the Asian Working Group for Sarcopenia (AWGS), are associated with fear of falling in elderly patients with diabetes. METHODS: The subjects were outpatients with diabetes who were at least 65 years of age when they visited our hospital. Sarcopenia was evaluated based on the AWGS definition. The cutoff values for the appendicular skeletal mass index (multi-frequency bioelectrical impedance method), grip strength, and walking speed were, respectively, 7...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29091148/relation-between-functional-mobility-and-dynapenia-in-institutionalized-frail-elderly
#18
Antonio Vinicius Soares, Elessandra Marcelino, Késsia Cristina Maia, Noé Gomes Borges
OBJECTIVE: To investigate the relation between functional mobility and dynapenia in institutionalized frail elderly. METHODS: A descriptive, correlational study involving 26 institutionalized elderly men and women, mean age 82.3±6 years. The instruments employed were the Mini Mental State Examination, the Geriatric Depression Scale, the International Physical Activity Questionnaire, the Timed Up and Go test, a handgrip dynamometer and a portable dynamometer for large muscle groups (shoulder, elbow and hip flexors, knee extensors and ankle dorsiflexors)...
July 2017: Einstein
https://www.readbyqxmd.com/read/29033231/the-combination-of-dynapenia-and-abdominal-obesity-as-a-risk-factor-for-worse-trajectories-of-iadl-disability-among-older-adults
#19
Tiago da Silva Alexandre, Shaun Scholes, Jair Licio Ferreira Santos, Yeda Aparecida de Oliveira Duarte, Cesar de Oliveira
BACKGROUND/OBJECTIVES: The concept of dynapenic obesity has been gaining great attention recently. However, there is little epidemiological evidence demonstrating that dynapenic abdominal obese individuals have worse trajectories of disability than those with dynapenia and abdominal obesity alone. Our aim was to investigate whether dynapenia combined with abdominal obesity can result in worse trajectories of instrumental activities of daily living (IADL) among English and Brazilian older adults over eight and ten years of follow-up, respectively...
October 2, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28986697/targeting-mitochondrial-function-and-proteostasis-to-mitigate-dynapenia
#20
REVIEW
Robert V Musci, Karyn L Hamilton, Benjamin F Miller
Traditionally, interventions to treat skeletal muscle aging have largely targeted sarcopenia-the age-related loss of skeletal muscle mass. Dynapenia refers to the age-related loss in skeletal muscle function due to factors outside of muscle mass, which helps to inform treatment strategies for aging skeletal muscle. There is evidence that mechanisms to maintain protein homeostasis and proteostasis, deteriorate with age. One key mechanism to maintain proteostasis is protein turnover, which is an energetically costly process...
January 2018: European Journal of Applied Physiology
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