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Andrea P Rossi, Lara Bianchi, Stefano Volpato, Stefania Bandinelli, Jack Guralnik, Mauro Zamboni, Luigi Ferrucci
Background: There are relatively few prospective studies evaluating the combined effect of abdominal obesity and low muscle strength on mortality, hospitalization, and incident disability. The aim of this study was to prospectively evaluate the prognostic value of dynapenic abdominal obesity on incident disability, hospitalization, and mortality in the population of the InCHIANTI study. Methods: In 370 men and 476 women aged between 65 and 95 years, handgrip strength, waist circumference (WC), body mass index, interleukin-6, C-reactive protein, education, medications, smoking status, and comorbidities were evaluated at the baseline...
March 8, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Ranjani N Moorthi, Keith G Avin
PURPOSE OF REVIEW: In this article, we review sarcopenia in chronic kidney disease (CKD). We aim to present how definitions of sarcopenia from the general population may pertain to those with CKD, its assessment by clinicians and emerging therapies for sarcopenia in CKD. For this review, we limit our description and recommendations to patients with CKD who are not on dialysis. RECENT FINDINGS: Poorer parameters of lean mass, strength and physical function are associated with worsening patient-centered outcomes such as limiting mobility, falls and mortality in CKD; however, the magnitude of these associations are different in those with and without CKD...
May 2017: Current Opinion in Nephrology and Hypertension
Esmee M Reijnierse, Nynke de Jong, Marijke C Trappenburg, Gerard Jan Blauw, Gillian Butler-Browne, Helena Gapeyeva, Jean-Yves Hogrel, Jamie S McPhee, Marco V Narici, Sarianna Sipilä, Lauri Stenroth, Rob C van Lummel, Mirjam Pijnappels, Carel G M Meskers, Andrea B Maier
BACKGROUND: Handgrip strength (HGS) is used to identify individuals with low muscle strength (dynapenia). The influence of the number of attempts on maximal HGS is not yet known and may differ depending on age and health status. This study aimed to assess how many attempts of HGS are required to obtain maximal HGS. METHODS: Three cohorts (939 individuals) differing in age and health status were included. HGS was assessed three times and explored as continuous and dichotomous variable...
February 2, 2017: Journal of Cachexia, Sarcopenia and Muscle
Masaki Iwamura, Masao Kanauchi
BACKGROUND: There are many reports that dynapenia, sarcopenia and frailty each have associations with bodily function or with Instrumental Activities of Daily Living (IADL). However, studies that compare all three conditions and their effects on IADL are lacking. The purpose of this study is to examine associations of sarcopenia, frailty, and dynapenia with IADL. METHODS: Participants included 123 community-dwelling older adults (31 men, 92 women,) aged 65 years or older (75...
January 3, 2017: BMC Geriatrics
Mylène Aubertin-Leheudre, Stephen Anton, Daniel P Beavers, Todd M Manini, Roger Fielding, Ann Newman, Tim Church, Stephen B Kritchevsky, David Conroy, Mary M McDermott, Anda Botoseneanu, Michelle E Hauser, Marco Pahor
OBJECTIVE: The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. METHODS: A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index...
April 1, 2017: Journal of the American Medical Directors Association
Valéria Teresa Saraiva Lino, Nádia Cristina Pinheiro Rodrigues, Gisele O'Dwyer, Mônica Kramer de Noronha Andrade, Inês Echenique Mattos, Margareth Crisóstomo Portela
INTRODUCTION: Sarcopenia is a condition diagnosed when the patient presents low muscle mass, plus low muscle strength or low physical performance. Muscle weakness in the oldest (dynapenia) is a major public health concern because it predicts future all-cause mortality and is associated with falls, disability, cardiovascular mortality and morbidity. Grip strength is a simple method for assessment of muscle function in clinical practice. OBJECTIVE: To estimate the grip strength and identify factors associated with handgrip strength variation in elderly people with low socioeconomic status...
2016: PloS One
Maude Dulac, Guy El Hajj Boutros, Charlotte Pion, Sébastien Barbat-Artigas, Gilles Gouspillou, Mylène Aubertin-Leheudre
Objective: To investigate whether handgrip strength normalized to body weight could be a useful clinical tool to identify dynapenia and assess functional capacity in post-menopausal women. Method: A total of 136 postmenopausal women were recruited. Body composition (Dual Energy X-ray Absorptiometry [DEXA], Bio-electrical Impedence Analysis [BIA]), grip strength (dynamometer) and functional capacity (senior fitness tests) were evaluated. Dynapenia was established according to a handgrip strength index (handgrip strength divided by body weight (BW) in Kg/KgBW) obtained from a reference population of young women: Type I dynapenic (<0...
November 2016: Brazilian Journal of Physical Therapy
Todd M Manini, Brian C Clark
No abstract text is available yet for this article.
September 2016: Journal of Cachexia, Sarcopenia and Muscle
W Kyle Mitchell, Daniel J Wilkinson, Bethan E Phillips, Jonathan N Lund, Kenneth Smith, Philip J Atherton
Healthy individuals maintain remarkably constant skeletal muscle mass across much of adult life, suggesting the existence of robust homeostatic mechanisms. Muscle exists in dynamic equilibrium whereby the influx of amino acids (AAs) and the resulting increases in muscle protein synthesis (MPS) associated with the intake of dietary proteins cancel out the efflux of AAs from muscle protein breakdown that occurs between meals. Dysregulated proteostasis is evident with aging, especially beyond the sixth decade of life...
July 2016: Advances in Nutrition
Scott C Adams, Roanne J Segal, Donald C McKenzie, James R Vallerand, Andria R Morielli, John R Mackey, Karen Gelmon, Christine M Friedenreich, Robert D Reid, Kerry S Courneya
The purpose of this study was to conduct an exploratory analysis of the START examining the effects of resistance exercise training (RET) and aerobic exercise training (AET) on sarcopenia, dynapenia, and associated quality of life (QoL) changes in breast cancer (BC) patients receiving adjuvant chemotherapy. Participants were randomized to usual care (UC) (n = 70), AET (n = 64), or RET (n = 66) for the duration of chemotherapy. Measures of sarcopenia [skeletal muscle index (SMI)] and dynapenia [upper extremity (UE) and lower extremity (LE) muscle dysfunction (MD)] were normalized relative to age-/sex-based clinical cut-points...
August 2016: Breast Cancer Research and Treatment
André de Camargo Smolarek, Luis Henrique Boiko Ferreira, Luis Paulo Gomes Mascarenhas, Steven R McAnulty, Karla Daniele Varela, Mônica C Dangui, Marcelo Paes de Barros, Alan C Utter, Tácito P Souza-Junior
Aging is a degenerative process marked by recognized functional, physiological, and metabolic impairments, such as dynapenia and diminished cognitive capacity. Therefore, the search for innovative strategies to prevent/delay these physiological and cognitive disorders is essential to guarantee the independence and life quality of an elderly population. The aim of this work is to verify the effect of a 12-week resistance exercise program on the general physical aptitude and cognitive capacities of elderly and sedentary women...
2016: Clinical Interventions in Aging
Michela Barichella, Giovanna Pinelli, Laura Iorio, Erica Cassani, Angela Valentino, Chiara Pusani, Valentina Ferri, Carlotta Bolliri, Marianna Pasqua, Gianni Pezzoli, Giuseppe Frazzitta, Emanuele Cereda
OBJECTIVES: To estimate prevalence of sarcopenia and dynapenia in outpatients with Parkinson disease (PD) and to investigate their association with the features of the disease. DESIGN: Cross-sectional study. SETTING: A specialized tertiary care center. PARTICIPANTS: Consecutive patients (n = 364) aged 65 years or older, affected by parkinsonian syndromes. MEASUREMENTS: Skeletal muscle mass (SMM), as well as strength and gait speed (GS) were assessed by bioimpedence analysis, handgrip dynamometry, and the 4-meter walking test, respectively...
July 1, 2016: Journal of the American Medical Directors Association
Timothy D Law, Leatha A Clark, Brian C Clark
For well over twenty centuries the muscle wasting (sarcopenia) and weakness (dynapenia) that occurs with old age has been a predominant concern of mankind. Exercise has long been suggested as a treatment to combat sarcopenia and dynapenia, as it exerts effects on both the nervous and muscular systems that are critical to positive physiological and functional adaptations (e.g., enhanced muscle strength). For more than two decades scientists have recognized the profound role that progressive resistance exercise training can have on increasing muscle strength, muscle size and functional capacity in older adults...
2016: Annual Review of Gerontology & Geriatrics
David Scott, Sahan D Chandrasekara, Laura L Laslett, Flavia Cicuttini, Peter R Ebeling, Graeme Jones
The purpose of this study is to determine whether low muscle mass (sarcopenia) or strength (dynapenia), in the presence of obesity, are associated with increased risk for osteoporosis and non-vertebral fracture over 5-10 years in community-dwelling older adults. N = 1089 volunteers (mean ± SD age 62 ± 7 years; 51 % female) participated at baseline and 761 attended follow-up clinics (mean 5.1 ± 0.5 years later). Total body, total hip and spine BMD, and appendicular lean and total fat mass were assessed by DXA...
July 2016: Calcified Tissue International
Doris Eglseer, Ruth Poglitsch, Regina Elisabeth Roller-Wirnsberger
Sarcopenia, as defined by the European working group on sarcopenia in older people (EWGSOP), is a highly prevalent syndrome characterized by age-related loss of muscle mass and muscle strength/power with impacts on physical function, health and quality of life in older people. The complex, multifaceted and still not completely elucidated etiology of sarcopenia and loss of muscle function (dynapenia) poses challenges for the design of interventional studies to combat loss of muscle strength. Several factors, however, have been demonstrated to have major impacts for maintenance of physiological muscle functioning, including nutrition and in particular specific nutrients...
February 2016: Zeitschrift Für Gerontologie und Geriatrie
Ana V Asaduroglu, M Tablada, J Cosiansi Bai, M Carrillo, M Canale, R Gallerano
UNLABELLED: Aging produces body changes such as redistribution of fat and loss of muscle mass and strength, predisposing to fragility, functional impairment and disability. OBJECTIVE: To analyze the relationship between body profile and physical and cognitive function by age in in ambulatory elderly women from the city of Córdoba. METHODS: 178 healthy older women (OW) ≥60 years free living were evaluated attending centers of retirees and day homes in the city of Córdoba...
2015: Revista de la Facultad de Ciencias Médicas
D J Cuthbertson, J A Bell, S Y Ng, G J Kemp, M Kivimaki, M Hamer
AIM: Obesity is a well-established risk factor for developing Type 2 diabetes. Evidence suggests that sarcopenia, the age-related decline in muscle mass and strength, may exacerbate diabetes risk in obese individuals. The aim of this study was to determine the combined effect of obesity and low muscle strength, dynapenia, on the risk of incident Type 2 diabetes in older adults. METHODS: Participants were 5953 (1670 obese) men and women from the English Longitudinal Study of Ageing without known Type 2 diabetes at baseline and for whom handgrip strength, biochemical and other clinical data were collected...
August 2016: Diabetic Medicine: a Journal of the British Diabetic Association
John A Batsis, Alicia J Zbehlik, Dawna Pidgeon, Stephen J Bartels
BACKGROUND: Obesity is associated with functional impairment, institutionalization, and increased mortality risk in elders. Dynapenia is defined as reduced muscle strength and is a known independent predictor of adverse events and disability. The synergy between dynapenia and obesity leads to worse outcomes than either independently. We identified the impact of dynapenic obesity in a cohort at risk for and with knee osteoarthritis on function. METHODS: We identified adults aged ≥ 60 years from the Osteoarthritis Initiative...
October 8, 2015: BMC Geriatrics
Ryoko Kawakami, Susumu S Sawada, I-Min Lee, Munehiro Matsushita, Yuko Gando, Takashi Okamoto, Koji Tsukamoto, Mitsuru Higuchi, Motohiko Miyachi, Steven N Blair
BACKGROUND: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear. METHODS: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 years. Weight and height were measured, and overweight/obesity was defined as a body mass index ≥25 kg/m(2). The prevalence of type 2 diabetes, defined as fasting plasma glucose ≥126 mg/dL and/or hemoglobin A1c ≥6...
2015: Journal of Epidemiology
Kathryn N Porter Starr, Connie W Bales
The health challenges prompted by obesity in the older adult population are poorly recognized and understudied. A defined treatment of geriatric obesity is difficult to establish, as it must take into account biological heterogeneity, age-related comorbidities, and functional limitations (sarcopenia/dynapenia). This retrospective article highlights the current understanding of the optimal body mass index (BMI) in later life, addressing appropriate recommendations based on BMI category, age, and health history...
August 2015: Clinics in Geriatric Medicine
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