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https://www.readbyqxmd.com/read/28931604/sublethal-total-body-irradiation-causes-long-term-deficits-in-thymus-function-by-reducing-lymphoid-progenitors
#1
Shiyun Xiao, Ivo D Shterev, Wen Zhang, Lauren Young, Jae-Hung Shieh, Malcolm Moore, Marcel van den Brink, Gregory D Sempowski, Nancy R Manley
Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation with aging remain unclear. In this study, we found that the impact of radiation on thymopoiesis in mice varied by sex and dose but, overall, thymopoiesis remained suppressed for ≥12 mo after a single exposure. Male and female mice showed a long-term dose-dependent reduction in thymic cKit(+) lymphoid progenitors that was maintained throughout life. Damage to hematopoietic stem cells (HSCs) in the bone marrow was dose dependent, with as little as 0...
September 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28929029/association-of-rs1801157-single-nucleotide-polymorphism-of-cxcl12-gene-in-breast-cancer-in-pakistan-and-in-silico-expression-analysis-of-cxcl12-cxcr4-associated-biological-regulatory-network
#2
Samra Khalid, Rumeza Hanif
BACKGROUND: C-X-C chemokine ligand 12 (CXCL12) has important implications in breast cancer (BC) pathogenesis. It is selectively expressed on B and T lymphocytes and is involved in hematopoiesis, thymocyte trafficking, stem cell motility, neovascularization, and tumorigenesis. The single nucleotide polymorphism (SNP) rs1801157 of CXCL12 gene has been found to be associated with higher risk of BC. METHODS: Our study focuses on the genotypic and allelic distribution of SNP (rs1801157; G/A) in Pakistani population as well as its association with the clinico-pathological features...
2017: PeerJ
https://www.readbyqxmd.com/read/28925480/the-role-of-pten-up-regulation-in-suppressing-glomerular-mesangial-cells-proliferation-and-nephritis-pathogenesis
#3
H-Y Gao, C-X Han
OBJECTIVE: Over-proliferation of mesangial cells is the major pathological change of mesangial proliferative glomerulonephritis (MPGN). PTEN-PI3K/AKT pathway plays a role in regulating proliferation of mesangial cells. Anti-thymocyte serum nephritis (ATSN) is a widely used animal model for studying MPGN. This study established ATSN model, on which the role of PTEN-PI3K/AKT signal pathway in MPGN pathogenesis was investigated. MATERIALS AND METHODS: ASTN rat model was established in parallel with control group...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28924581/data-on-the-effects-of-eif6-downmodulation-on-the-proportions-of-innate-and-adaptive-immune-system-cell-subpopulations-and-on-thymocyte-maturation
#4
Nicola Manfrini, Sara Ricciardi, Annarita Miluzio, Maya Fedeli, Alessandra Scagliola, Simone Gallo, Thure Adler, Dirk H Busch, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Stefano Biffo
The data described in this article are related to "High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4(+) T cells in both mice and humans" (Manfrini et al., in press) [1]. eIF6 is a translation initiation factor required for ribosomal biogenesis (Sanvito et al., 1999) [2] and for proper translational initiation (Gallo and Manfrini, 2015; Miluzio et al., 2016) [3], [4] whose protein abundance requires tight regulation...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28920671/development-of-a-multifunctional-nanobiointerface-based-on-self-assembled-fusion-protein-rsbpa-zz-for-blood-cell-enrichment-and-phenotyping
#5
Mario Rothbauer, Martin Frauenlob, Karoline Gutkas, Michael B Fischer, Eva Kathrin Sinner, Seta Küpcü, Peter Ertl
We present a multifunctional nanobiointerface for blood cell capture and phenotyping applications that features both excellent antifouling properties and high antibody activity. Multifunctionality is accomplished by modifying polymeric materials using self-assembled S-layer fusion-protein rSbpA/ZZ to immobilize high density antibodies at the two protein A binding sites of the rSbpA/ZZ nanolattice structure. Controlled orientation and alignment of the antibodies reduced antibody consumption 100-fold and increased cell capture efficiency 4-fold over standard methodologies...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28915633/selection-of-optimal-molecular-targets-for-tumor-specific-imaging-in-pancreatic-ductal-adenocarcinoma
#6
Willemieke S Tummers, Arantza Farina-Sarasqueta, Martin C Boonstra, Hendrica A Prevoo, Cornelis F Sier, Jan S Mieog, Johannes Morreau, Casper H van Eijck, Peter J Kuppen, Cornelis J van de Velde, Bert A Bonsing, Alexander L Vahrmeijer, Rutger-Jan Swijnenburg
Discrimination of pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP) or peritumoral inflammation is challenging, both at preoperative imaging and during surgery, but it is crucial for proper therapy selection. Tumor-specific molecular imaging aims to enhance this discrimination and to help select and stratify patients for resection. We evaluated various biomarkers for the specific identification of PDAC and associated lymph node metastases. Using immunohistochemistry (IHC), expression levels and patterns were investigated of integrin αvβ6, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), Cathepsin E (Cath E), epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), thymocyte differentiation antigen 1 (Thy1), and urokinase-type plasminogen activator receptor (uPAR)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900678/socs1-regulator-of-t-cells-in-autoimmunity-and-cancer
#7
Subburaj Ilangumaran, Diwakar Bobbala, Sheela Ramanathan
SOCS1 is a negative feedback regulator of cytokine and growth factor receptor signaling, and plays an indispensable role in attenuating interferon gamma signaling. Studies on SOCS1-deficient mice have established a crucial role for SOCS1 in regulating CD8(+) T cell homeostasis. In the thymus, SOCS1 prevents thymocytes that had failed positive selection from surviving and expanding, ensures negative selection and prevents inappropriate developmental skewing toward the CD8 lineage. In the periphery, SOCS1 not only controls production of T cell stimulatory cytokines but also attenuates the sensitivity of CD8(+) T cells to synergistic cytokine stimulation and antigen non-specific activation...
September 13, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28899870/mbd3-nurd-controls-lymphoid-cell-fate-and-inhibits-tumorigenesis-by-repressing-a-b-cell-transcriptional-program
#8
Stephen J Loughran, Federico Comoglio, Fiona K Hamey, Alice Giustacchini, Youssef Errami, Eleanor Earp, Berthold Göttgens, Sten Eirik W Jacobsen, Adam J Mead, Brian Hendrich, Anthony R Green
Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin remodeling complexes. Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneering during B cell programming of multipotent lymphoid progenitors by restricting chromatin accessibility at B cell enhancers and promoters...
September 12, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28899772/change-in-plasma-membrane-potential-of-rat-thymocytes-by-tert-butylhydroquinone-a-food-additive-possible-risk-on-lymphocytes
#9
Maki Takeda, Keisuke Oyama, Norio Kamemura, Kaori Kanemaru, Keizo Yuasa, Kumio Yokoigawa, Yasuo Oyama
Tertiary butylhydroquinone (TBHQ) is a food additive and has various beneficial actions under in vitro and in vivo experimental conditions. Therefore, it is necessary to collect additional data on the toxicity of TBHQ in order to avoid adverse effects during clinical applications. Changes in plasma membrane potential are associated with changes in physiological functions even in non-excitable cells such as lymphocytes. Thus, compounds that affect membrane potential may modify some lymphocytic functions. The effect of TBHQ on plasma membrane potential was examined in rat thymocytes using flow cytometric techniques...
September 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28890540/fine-tuning-of-thymocyte-development-by-ubiquitination-mediated-stability-control-of-the-escrt-protein-chmp5
#10
Masashi Watanabe, Shigetsugu Hatakeyama
No abstract text is available yet for this article.
September 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28890536/a-key-role-for-il-7r-in-the-generation-of-microenvironments-required-for-thymic-dendritic-cells
#11
Amanda J Moore, Tracy Sh In, Ashton Trotman-Grant, Kogulan Yoganathan, Bertrand Montpellier, Cynthia J Guidos, Juan Carlos Zúñiga-Pflücker, Michele K Anderson
Interleukin-7 receptor (IL-7R) signaling is critical for multiple stages of T-cell development, but a role in the establishment of the mature thymic architecture needed for T-cell development and thymocyte selection has not been established. Crosstalk signals between developing thymocytes and thymic epithelial cell (TEC) precursors are critical for their differentiation into cortical TECs (cTECs) and medullary TECs (mTECs). Additionally, mTECs-derived factors have been implicated in the recruitment of thymic dendritic cells (DCs) and intrathymic DC development...
September 11, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28886425/enhanced-thymocyte-apoptosis-induced-by-maternal-undernutrition-in-late-gestation-results-in-declined-mature-t-cells-in-rat-fetal-thymus
#12
Wen Qu, Liang-Peng Ma, Hui-Yi Yan, Sha Liu, Han-Xiao Liu, Ting Chen, Li-Fang Hou, Jie Ping
This study was designed to observe the effects of maternal food restriction (MFR) on the development of fetal thymus in different gestation periods. Timed pregnant rats were randomized into 3 groups: CN (free access to standard chow throughout gestation), MFR0-21 (50% MFR throughout gestation), MFR0-14 (50% MFR from gestational day (GD) 0 to GD14, early-mid gestation). Results showed that MFR during early-mid period had few impact on the fetal thymus and T cell subpopulations. However, MFR throughout gestation resulted in thymic atrophy, deceased frequency of both CD4(+) and CD8(+) single positive (SP) T cells and enhanced thymocyte apoptosis in fetus...
August 24, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28885618/loss-of-bim-augments-resistance-of-atm-deficient-thymocytes-to-dna-damage-induced-apoptosis-but-does-not-accelerate-lymphoma-development
#13
Alex Rd Delbridge, Stephanie Grabow, Andreas Strasser
No abstract text is available yet for this article.
September 8, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28883990/the-development-of-t-cells-from-stem-cells-in-mice-and-humans
#14
REVIEW
Farbod Famili, Anna-Sophia Wiekmeijer, Frank Jt Staal
T cells develop from hematopoietic stem cells in the specialized microenvironment of the thymus. The main transcriptional players of T-cell differentiation such as Notch, Tcf-1, Gata3 and Bcl11b have been identified, but their role and regulation are not yet completely understood. In humans, functional experiments on T-cell development have traditionally been rather difficult to perform, but novel in vitro culture systems and in vivo xenograft models have allowed detailed studies on human T-cell development...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28881594/the-mir-106a-363-xpcl1-mirna-cluster-induces-murine-t-cell-lymphoma-despite-transcriptional-activation-of-the-p27-kip1-cell-cycle-inhibitor
#15
Daniel A Kuppers, Thomas M Schmitt, Harry C Hwang, Lavanya Samraj, Bruce E Clurman, Matthew L Fero
The miR-106a~363 cluster encodes 6 miRNAs on the X-chromosome which are abundant in blood cells and overexpressed in a variety of malignancies. The constituent miRNA of miR-106a~363 have functional activities in vitro that are predicted to be both oncogenic and tumor suppressive, yet little is known about their physiological functions in vivo. Mature miR-106a~363 (Mirc2) miRNAs are processed from an intragenic, non-protein encoding gene referred to as Xpcl1 (or Kis2), situated at an X-chromosomal locus frequently targeted by retroviruses in murine lymphomas...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878277/increased-tcr-signal-strength-in-dn-thymocytes-promotes-development-of-gut-tcr%C3%AE-%C3%AE-cd8%C3%AE-%C3%AE-intraepithelial-lymphocytes
#16
Capucine L Grandjean, Nital Sumaria, Stefania Martin, Daniel J Pennington
CD4((+))CD8((+)) "double positive" (DP) thymocytes differentiate into diverse αβ T cell sub-types using mechanistically distinct programs. For example, conventional αβ T cells develop from DP cells after partial-agonist T cell receptor (TCR) interactions with self-peptide/MHC, whereas unconventional αβ T cells, such as TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes (IELs), require full-agonist TCR interactions. Despite this, DP cells appear homogeneous, and it remains unclear how distinct TCR signalling instructs distinct developmental outcomes...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878001/nlr-nod1-signaling-promotes-survival-of-bcr-engaged-mature-b-cells-through-up-regulated-nod1-as-a-positive-outcome
#17
Kyoko Hayakawa, Anthony M Formica, Yan Zhou, Daiju Ichikawa, Masanao Asano, Yue-Sheng Li, Susan A Shinton, Joni Brill-Dashoff, Gabriel Núñez, Richard R Hardy
Although B cell development requires expression of the B cell antigen receptor (BCR), it remains unclear whether engagement of self-antigen provides a positive impact for most B cells. Here, we show that BCR engagement by self-ligand during development in vivo results in up-regulation of the Nod-like receptor member Nod1, which recognizes the products of intestinal commensal bacteria. In anti-thymocyte/Thy-1 autoreactive BCR knock-in mice lacking self-Thy-1 ligand, immunoglobulin light chain editing occurred, generating B cells with up-regulated Nod1, including follicular and marginal zone B cells with natural autoreactivity...
September 6, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28877990/grb2-mediated-recruitment-of-usp9x-to-lat-enhances-themis-stability-following-thymic-selection
#18
Anne Garreau, Gaëtan Blaize, Jérémy Argenty, Nelly Rouquié, Audrey Tourdès, Stephen A Wood, Abdelhadi Saoudi, Renaud Lesourne
Themis is a new component of the TCR signaling machinery that plays a critical role during T cell development. The positive selection of immature CD4(+)CD8(+) double-positive thymocytes and their commitment to the CD4(+)CD8(-) single-positive stage are impaired in Themis(-/-) mice, suggesting that Themis might be important to sustain TCR signals during these key developmental processes. However, the analysis of Themis mRNA levels revealed that Themis gene expression is rapidly extinguished during positive selection...
September 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28873970/immunosuppressive-agents-in-adult-kidney-transplantation-in-the-national-health-service-a-model-based-economic-evaluation
#19
Tristan M Snowsill, Jason Moore, Ruben E Mujica Mota, Jaime L Peters, Tracey L Jones-Hughes, Nicola J Huxley, Helen F Coelho, Marcela Haasova, Chris Cooper, Jenny A Lowe, Jo L Varley-Campbell, Louise Crathorne, Matt J Allwood, Rob Anderson
Background: Immunosuppression is required in kidney transplantation to prevent rejection and prolong graft survival. We conducted an economic evaluation to support England's National Institute for Health and Care Excellence in developing updated guidance on the use of immunosuppression, incorporating new immunosuppressive agents, and addressing changes in pricing and the evidence base. Methods: A discrete-time state transition model was developed to simulate adult kidney transplant patients over their lifetime...
July 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28871661/update-on-aire-and-thymic-negative-selection
#20
REVIEW
Geraldo Aleixo Passos, Cesar A Speck-Hernandez, Amanda Freire Assis, Daniella A Mendes-da-Cruz
Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), cloned and sequenced. Its importance goes beyond its link with human autoimmune disease. Aire identification opened new perspectives to better understand the molecular basis of central tolerance and self-non-self-distinction, the main properties of the immune system. During these two last decades, a growing number of immunologists and molecular geneticists have made important discoveries about the function of Aire, which is essentially a pleiotropic gene...
September 4, 2017: Immunology
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