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https://www.readbyqxmd.com/read/29768262/mir-598-suppresses-invasion-and-migration-by-negative-regulation-of-derlin-1-and-epithelial-mesenchymal-transition-in-non-small-cell-lung-cancer
#1
Fengming Yang, Ke Wei, Zhiqiang Qin, Weitao Liu, Chuchu Shao, Chaoshan Wang, Ling Ma, Mengyan Xie, Yongqian Shu, Hua Shen
BACKGROUND/AIMS: MicroRNAs regulate a wide range of biological processes of non-small cell lung cancer (NSCLC). Although miR-598 has been reported to act as a suppressor in osteosarcoma and colorectal cancer, the physiological function of miR-598 in NSCLC remains unknown. In this study, the role of miR-598 in NSCLC was investigated. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to estimate the expression of miR-598 and Derlin-1 (DERL1) in both NSCLC tissues and cell lines...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29765562/a-myriad-of-roles-of-mir-25-in-health-and-disease
#2
REVIEW
Márta Sárközy, Zsuzsanna Kahán, Tamás Csont
Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in different predicted target mRNAs...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29755427/16s-rrna-gene-sequencing-for-deciphering-the-colorectal-cancer-gut-microbiome-current-protocols-and-workflows
#3
REVIEW
Muhammad-Afiq Osman, Hui-Min Neoh, Nurul-Syakima Ab Mutalib, Siok-Fong Chin, Rahman Jamal
The human gut holds the densest microbiome ecosystem essential in maintaining a healthy host physiology, whereby disruption of this ecosystem has been linked to the development of colorectal cancer (CRC). The advent of next-generation sequencing technologies such as the 16S rRNA gene sequencing has enabled characterization of the CRC gut microbiome architecture in an affordable and culture-free approach. Nevertheless, the lack of standardization in handling and storage of biospecimens, nucleic acid extraction, 16S rRNA gene primer selection, length, and depth of sequencing and bioinformatics analyses have contributed to discrepancies found in various published studies of this field...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29748135/oncogenic-kras-suppresses-store-operated-ca-2-entry-and-i-crac-through-erk-pathway-dependent-remodelling-of-stim-expression-in-colorectal-cancer-cell-lines
#4
Cristina Pierro, Xuexin Zhang, Cynthia Kankeu, Mohamed Trebak, Martin D Bootman, H Llewelyn Roderick
The KRAS GTPase plays a fundamental role in transducing signals from plasma membrane growth factor receptors to downstream signalling pathways controlling cell proliferation, survival and migration. Activating KRAS mutations are found in 20% of all cancers and in up to 40% of colorectal cancers, where they contribute to dysregulation of cell processes underlying oncogenic transformation. Multiple KRAS-regulated cell functions are also influenced by changes in intracellular Ca2+ levels that are concurrently modified by receptor signalling pathways...
March 14, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29736667/outcomes-following-colorectal-resection-in-kidney-transplant-recipients
#5
Sandra R DiBrito, Yewande Alimi, Israel O Olorundare, Courtenay M Holscher, Christine E Haugen, Dorry L Segev, Jacqueline Garonzik-Wang
BACKGROUND: Kidney transplant recipients (KTR) are at increased risk of requiring colorectal resection compared to the general population. Given the need for lifelong immunosuppression and the physiologic impact of years of renal replacement, we hypothesized that colorectal resection may be riskier for this unique population. METHODS: We investigated the differences in mortality, morbidity, length of stay (LOS), and cost between 2410 KTR and 1,433,437 non-KTR undergoing colorectal resection at both transplant and non-transplant centers using the National Inpatient Sample between 2000 and 2013, adjusting for patient and hospital level factors...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29731866/microrna-hsa-let-7e-5p-as-a-potential-prognosis-marker-for-rectal-carcinoma-with-liver-metastases
#6
Wenfeng Chen, Guosheng Lin, Yizhou Yao, Jishen Chen, Hanli Shui, Qinghai Yang, Xiaoya Wang, Xiaoyuan Weng, Ling Sun, Fei Chen, Sheng Yang, Yufeng Yang, Yongjian Zhou
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that target mRNAs for translational repression or cleavage. The present study was conducted to identify differentially expressed miRNAs in primary tumor tissues of rectal carcinoma (RC) that may be associated with heterochrony hepatic metastasis (HHM). Samples were collected exclusively from patients with RC but not colon cancer (CC); Next-generation high-throughput sequencing technology and bioinformatics tools were used to profile and analyze small RNAs and their corresponding targets in primary tumor tissues with HHM (n=2) or without metastases (non-metastatic, NM; n=2)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29731748/oral-bacterial-and-fungal-microbiome-impacts-colorectal-carcinogenesis
#7
REVIEW
Klara Klimesova, Zuzana Jiraskova Zakostelska, Helena Tlaskalova-Hogenova
Host's physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29730070/exercise-prehabilitation-in-elective-intra-cavity-surgery-a-role-within-the-eras-pathway-a-narrative-review
#8
REVIEW
Samuel T Orange, Matthew J Northgraves, Phil Marshall, Leigh A Madden, Rebecca V Vince
The Enhanced Recovery after Surgery (ERAS) model integrates several elements of perioperative care into a standardised clinical pathway for surgical patients. ERAS programmes aim to reduce the rate of complications, improve surgical recovery, and limit postoperative length of hospital stay (LOHS). One area of growing interest that is not currently included within ERAS protocols is the use of exercise prehabilitation (PREHAB) interventions. PREHAB refers to the systematic process of improving functional capacity of the patient to withstand the upcoming physiological stress of surgery...
May 3, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29722430/review-article-short-chain-fatty-acids-as-potential-therapeutic-agents-in-human-gastrointestinal-and-inflammatory-disorders
#9
REVIEW
P A Gill, M C van Zelm, J G Muir, P R Gibson
BACKGROUND: Butyrate, propionate and acetate are short chain fatty acids (SCFA), important for maintaining a healthy colon and are considered as protective in colorectal carcinogenesis. However, they may also regulate immune responses and the composition of the intestinal microbiota. Consequently, their importance in a variety of chronic inflammatory diseases is emerging. AIMS: To review the physiology and metabolism of SCFA in humans, cellular and molecular mechanisms by which SCFA may act in health and disease, and approaches for therapeutic delivery of SCFA...
May 3, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29719203/the-burgeoning-role-of-cytochrome-p450-mediated-vitamin-d-metabolites-against-colorectal-cancer
#10
REVIEW
Peili Wang, Xuan Qin, Mingyao Liu, Xin Wang
The metabolites of vitamin D3 (VD3) mediated by different cytochrome P450 (CYP) enzymes, play fundamental roles in many physiological processes in relation to human health. These metabolites regulate a variety of cellular signal pathways through the direct binding of activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodimeric complex to specific DNA sequences. Thus, the polymorphisms of VDR and VD3 metabolizing enzymes lead to differentiated efficiency of VD3 and further affect serum VD3 levels...
April 30, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29696237/the-interval-walking-in-colorectal-cancer-i-walk-crc-study-design-methods-and-recruitment-results-of-a-randomized-controlled-feasibility-trial
#11
Anna Banck-Petersen, Cecilie K Olsen, Sissal S Djurhuus, Anita Herrstedt, Sarah Thorsen-Streit, Mathias Ried-Larsen, Kell Østerlind, Jens Osterkamp, Peter-Martin Krarup, Kirsten Vistisen, Camilla S Mosgaard, Bente K Pedersen, Pernille Højman, Jesper F Christensen
Background: Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The "Interval Walking in Colorectal Cancer"(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29693702/glycine-and-succinic-acid-are-effective-indicators-of-the-suppression-of-epithelial-mesenchymal-transition-by-fucoxanthinol-in-colorectal-cancer-stem-like-cells
#12
Masaru Terasaki, Masatoshi Mima, Satoki Kudoh, Tetsuya Endo, Hayato Maeda, Junichi Hamada, Kazumi Osada, Kazuo Miyashita, Michihiro Mutoh
Fucoxanthinol (FxOH) is a strong anticancer metabolite of fucoxanthin that accumulates in abundance in edible brown algae and promises human health benefits. FxOH has been shown to suppress tumorigenicity and sphere formation in human colorectal cancer stem cell (CCSC)-like spheroids (colonospheres, Csps). In the present study, we aimed to clarify the inhibitory activity of FxOH on epithelial-mesenchymal transition (EMT), which is essential for cancer recurrence and distant metastasis, and to identify intracellular low-molecular-weight metabolites that may be useful for evaluating the cellular effects of FxOH on CCSCs...
April 24, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29682554/differential-expression-patterns-of-eph-receptors-and-ephrin-ligands-in-human-cancers
#13
REVIEW
Chung-Ting Jimmy Kou, Raj P Kandpal
Eph receptors constitute the largest family of receptor tyrosine kinases, which are activated by ephrin ligands that either are anchored to the membrane or contain a transmembrane domain. These molecules play important roles in the development of multicellular organisms, and the physiological functions of these receptor-ligand pairs have been extensively documented in axon guidance, neuronal development, vascular patterning, and inflammation during tissue injury. The recognition that aberrant regulation and expression of these molecules lead to alterations in proliferative, migratory, and invasive potential of a variety of human cancers has made them potential targets for cancer therapeutics...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29663265/telemedicine-and-mobile-health-technology-are-effective-in-the-management-of-digestive-diseases-a-systematic-review
#14
REVIEW
Brian C Helsel, Joel E Williams, Kristen Lawson, Jessica Liang, Jonathan Markowitz
BACKGROUND: Mobile applications and interactive websites are an increasingly used method of telemedicine, but their use lacks evidence in digestive diseases. AIM: This study aims to explore digestive disease studies that use telemedicine to effectively manage disease activity, help monitor symptoms, improve compliance to the treatment protocol, increase patient satisfaction, and enhance the patient-to-provider communication. METHODS: EBSCO, PubMed, and Web of Science databases were searched using Medical Subject Headings and other keywords to identify studies that utilized telemedicine in patients with digestive disease...
April 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29615557/wingless-wnt-signaling-in-intestinal-development-homeostasis-regeneration-and-tumorigenesis-a-drosophila-perspective
#15
REVIEW
Ai Tian, Hassina Benchabane, Yashi Ahmed
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis...
March 28, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615276/-cr-possum-and-surgical-apgar-score-as-predictive-factors-for-patients-allocation-after-colorectal-surgery
#16
Sílvia Pinho, Filipa Lagarto, Blandina Gomes, Liliana Costa, Catarina S Nunes, Carla Oliveira
BACKGROUND AND OBJECTIVES: Surgical patients frequently require admission in high-dependency units or intensive care units. Resources are scarce and there are no universally accepted admission criteria, so patients' allocation must be optimized. The purpose of this study was to investigate the relationship between postoperative destination of patients submitted to colorectal surgery and the scores ColoRectal Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (CR-POSSUM) and Surgical Apgar Score (SAS) and, secondarily find cut-offs to aid this allocation...
March 31, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29590399/patterns-of-cancer-treatment-in-different-age-groups-in-japan-an-analysis-of-hospital-based-cancer-registry-data-2012-2015
#17
Ayako Okuyama, Takahiro Higashi
Background: Because of the physiological decline and the diversity of preferences, treating older patients with cancer is challenging. Given the insufficient evidence applicable to treating cancer in older patients, some clinical guidance is necessary. This study provides a description of current treatment practices in Japan, which may shed light on possible treatment options. Methods: Using data from the national database of hospital-based cancer registries, we described the first-course treatment of nine common cancers in patients who received care in Designated Cancer Care Hospitals between 2012 and 2015...
March 26, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29589318/use-of-organoids-to-characterize-signaling-pathways-in-cancer-initiation
#18
Christina Oatway, Calley L Hirsch, Alex Gregorieff
The development of intestinal organoid technology has greatly accelerated research in the field of colorectal cancer. Contrary to traditional cancer cell lines, organoids are composed of multiple cell types arranged in 3D structures highly reminiscent of their native tissues. Thus, organoids provide a near-physiological and readily accessible model to study tissue morphogenesis, adult stem cell behavior and tumorigenesis. Here, we provide protocols for establishing intestinal organoid cultures from genetically modified mouse lines and describe methods to overexpress and knockout genes of interest using lentiviral-based approaches...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29566385/a-comprehensive-assessment-of-the-role-of-mirnas-as-biomarkers-in-gastroenteropancreatic-neuroendocrine-tumors
#19
Anna Malczewska, Mark Kidd, Somer Matar, Beata Kos-Kudla, Irvin M Modlin
BACKGROUND/AIMS: A key issue in neuroendocrine neoplasia management is the identification of blood signatures that specifically define the activity of a cancer or local tumor microenvironment. MicroRNAs (miRNAs) may represent such a candidate. To evaluate their clinical utility as biomarkers in gastroenteropancreatic neuroendocrine tumors (GEP-NETs), we assessed their expression in tissue and blood. METHODS: A systematic review of PubMed was undertaken to identify studies investigating miRNAs in GEP-NETs and their utility as blood or tissue biomarkers...
March 22, 2018: Neuroendocrinology
https://www.readbyqxmd.com/read/29545333/a-mir-29b-byproduct-sequence-exhibits-potent-tumor-suppressive-activities-via-inhibition-of-nf-%C3%AE%C2%BAb-signaling-in-kras-mutant-colon-cancer-cells
#20
Akira Inoue, Tsunekazu Mizushima, Xin Wu, Daisuke Okuzaki, Nanami Kambara, Sho Ishikawa, Jiaqi Wang, Yamin Qian, Haruka Hirose, Yuhki Yokoyama, Ryo Ikeshima, Masayuki Hiraki, Norikatsu Miyoshi, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto
We previously demonstrated that miR-29b-3p is a hopeful miRNA-based therapy against colorectal cancer. In this study, we aimed to clarify a value of miR-29b-1-5p as a next-generation treatment, especially for KRAS -mutant colorectal cancer. RT-PCR assay showed that the expression of miR-29b-3p was high, and its partner strand, miR-29b-1-5p, level was only negligible in clinical colorectal cancer samples. Mimic-miR-29b-1-5p significantly inhibited proliferation of KRAS -mutant colorectal cancer cell lines DLD1 and SW480 and KRAS wild-type HT29 cells...
May 2018: Molecular Cancer Therapeutics
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