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https://www.readbyqxmd.com/read/28716749/the-targeting-properties-of-folate-conjugate-pluronic-f127-poly-lactic-co-glycolic-nanoparticles
#1
Yue Yuan Luo, Xiang Yuan Xiong, Feng Cheng, Yan Chun Gong, Zi Ling Li, Yu Ping Li
Novel Folated Pluronic F127/poly (lactic-co-glycolic) (FA-F127-PLGA) and PLGA-F127-PLGA block copolymer were synthesized and nanoparticles self-assembled from these two copolymers were prepared by dialysis method. Paclitaxel (PTX) was successfully encapsulated in these two nanoparticles. According to in vitro release studies of PTX-loaded nanoparticles, after an initial burst release during the first 11h, the entrapped PTX released slowly in the following 82h. The cytotoxicity studies demonstrated that the in vitro antitumor effect of PTX could be improved by encapsulating PTX into PLGA-F127-PLGA nanoparticles...
July 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28710927/effects-of-brief-mindful-breathing-and-loving-kindness-meditation-on-shame-and-social-problem-solving-abilities-among-individuals-with-high-borderline-personality-traits
#2
Shian-Ling Keng, Jun Xian Tan
Borderline personality disorder (BPD) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities, including chronic shame and deficits in social problem solving (SPS) abilities. Little research however, has examined strategies that may alleviate shame and SPS deficits among individuals with BPD traits. Using a laboratory experimental approach, the present study compared the effects of a brief mindfulness versus loving-kindness meditation (LKM) induction on shame and SPS abilities in a sample of adults with high BPD traits...
July 8, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28702717/mindfulness-based-stress-reduction-and-group-support-decrease-stress-in-adolescents-with-cardiac-diagnoses-a-randomized-two-group-study
#3
Vicki A Freedenberg, Pamela S Hinds, Erika Friedmann
Adolescents with cardiac diagnoses face unique challenges that can cause psychosocial distress. This study compares a Mindfulness-Based Stress Reduction (MBSR) program to a video online support group for adolescents with cardiac diagnoses. MBSR is a structured psycho-educational program which includes yoga, meditation, cognitive restructuring, and group support. A published feasibility study by our group showed significant reduction in anxiety following this intervention. Participants were randomized to MBSR or video online support group, and completed measures of anxiety, depression, illness-related stress, and coping pre- and post-6-session interventions...
July 12, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28702704/ezrin-orchestrates-signal-transduction-in-airway-cells
#4
Lei-Miao Yin, Ting-Ting Duan, Luis Ulloa, Yong-Qing Yang
Ezrin is a critical structural protein that organizes receptor complexes and orchestrates their signal transduction. In this study, we review the ezrin-meditated regulation of critical receptor complexes, including the epidermal growth factor receptor (EGFR), CD44, vascular cell adhesion molecule (VCAM), and the deleted in colorectal cancer (DCC) receptor. We also analyze the ezrin-meditated regulation of critical pathways associated with asthma, such as the RhoA, Rho-associated protein kinase (ROCK), and protein kinase A (cAMP/PKA) pathways...
July 13, 2017: Reviews of Physiology, Biochemistry and Pharmacology
https://www.readbyqxmd.com/read/28701912/brain-responses-to-a-6-hz-binaural-beat-effects-on-general-theta-rhythm-and-frontal-midline-theta-activity
#5
Nantawachara Jirakittayakorn, Yodchanan Wongsawat
A binaural beat is a beat phenomenon that is generated by the dichotic presentation of two almost equivalent pure tones but with slightly different frequencies. The brain responses to binaural beats remain controversial; therefore, the aim of this study was to investigate theta activity responses to a binaural beat by controlling factors affecting localization, including beat frequency, carrier tone frequency, exposure duration, and recording procedure. Exposure to a 6-Hz binaural beat on a 250 Hz carrier tone for 30 min was utilized in this study...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28698643/effects-of-gratitude-meditation-on-neural-network-functional-connectivity-and-brain-heart-coupling
#6
Sunghyon Kyeong, Joohan Kim, Dae Jin Kim, Hesun Erin Kim, Jae-Jin Kim
A sense of gratitude is a powerful and positive experience that can promote a happier life, whereas resentment is associated with life dissatisfaction. To explore the effects of gratitude and resentment on mental well-being, we acquired functional magnetic resonance imaging and heart rate (HR) data before, during, and after the gratitude and resentment interventions. Functional connectivity (FC) analysis was conducted to identify the modulatory effects of gratitude on the default mode, emotion, and reward-motivation networks...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694775/yoga-meditation-and-mind-body-health-increased-bdnf-cortisol-awakening-response-and-altered-inflammatory-marker-expression-after-a-3-month-yoga-and-meditation-retreat
#7
B Rael Cahn, Matthew S Goodman, Christine T Peterson, Raj Maturi, Paul J Mills
Thirty-eight individuals (mean age: 34.8 years old) participating in a 3-month yoga and meditation retreat were assessed before and after the intervention for psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, and pro- and anti-inflammatory cytokines. Participation in the retreat was found to be associated with decreases in self-reported anxiety and depression as well as increases in mindfulness. As hypothesized, increases in the plasma levels of BDNF and increases in the magnitude of the cortisol awakening response (CAR) were also observed...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28694204/the-mind-body-wellness-in-supportive-housing-mi-wish-study-design-and-rationale-of-a-cluster-randomized-controlled-trial-of-tai-chi-in-senior-housing
#8
Peter M Wayne, Margaret M Gagnon, Eric A Macklin, Thomas G Travison, Bradley Manor, Margie Lachman, Cindy P Thomas, Lewis A Lipsitz
Supporting the health of growing numbers of frail older adults living in subsidized housing requires interventions that can combat frailty, improve residents' functional abilities, and reduce their health care costs. Tai Chi is an increasingly popular multimodal mind-body exercise that incorporates physical, cognitive, social, and meditative components in the same activity and offers a promising intervention for ameliorating many of the conditions that lead to poor health and excessive health care utilization...
July 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28689600/meditation-and-the-brain-neuronal-correlates-of-mindfulness-as-assessed-with-near-infrared-spectroscopy
#9
Friederike Gundel, Johanna von Spee, Sabrina Schneider, Florian B Haeussinger, Martin Hautzinger, Michael Erb, Andreas J Fallgatter, Ann-Christine Ehlis
Mindfulness meditation as a therapeutic intervention has been shown to have positive effects on psychological problems such as depression, pain or anxiety disorders. In this study, we used functional near-infrared spectroscopy (fNIRS) to detect differences in hemodynamic responses of meditation experts (14 participants) and a control group (16 participants) in a resting and a mindfulness condition. In both conditions, the sound of a meditation bowl was used to find group differences in the auditory system and adjacent cortical areas...
April 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28689469/a-mindfulness-program-manual-for-people-with-dementia
#10
Joanne Chan, Anna Churcher Clarke, Lindsay Royan, Joshua Stott, Aimee Spector
This article describes a 10-session group-based Mindfulness Program for people with mild to moderate dementia. It aims to equip people with dementia with skills to manage psychological distress, with support from carers. The Mindfulness Program was developed through reviews of existing literature, consultation with experts, and a focus group with people with dementia. In a randomized controlled feasibility and pilot trial with people with mild to moderate dementia in care homes, it was found to significantly increase quality of life...
July 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28687417/just-a-minute-meditation-rapid-voluntary-conscious-state-shifts-in-long-term-meditators
#11
Ajay Kumar Nair, Arun Sasidharan, John P John, Seema Mehrotra, Bindu M Kutty
Meditation induces a modified state of consciousness that remains under voluntary control. Can meditators rapidly and reversibly bring about mental state changes on demand? To check, we carried out 128 channel EEG recordings on Brahma Kumaris Rajayoga meditators (36 long term: median 14240h meditation; 25 short term: 1095h) and controls (25) while they tried to switch every minute between rest and meditation states in different conditions (eyes open and closed; before and after an engaging task). Long term meditators robustly shifted states with enhanced theta power (4-8Hz) during meditation...
July 4, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28683799/mindfulness-and-compassion-oriented-practices-at-work-reduce-distress-and-enhance-self-care-of-palliative-care-teams-a-mixed-method-evaluation-of-an-on-the-job-program
#12
Claudia L Orellana-Rios, Lukas Radbruch, Martina Kern, Yesche U Regel, Andreas Anton, Shane Sinclair, Stefan Schmidt
BACKGROUND: Maintaining a sense of self-care while providing patient centered care, can be difficult for practitioners in palliative medicine. We aimed to pilot an "on the job" mindfulness and compassion-oriented meditation training for interdisciplinary teams designed to reduce distress, foster resilience and strengthen a prosocial motivation in the clinical encounter. METHODS: Our objective was to explore the feasibility and effectiveness of this newly developed training...
July 6, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28682643/yy1-is-required-for-posttranscriptional-stability-of-sox2-and-oct4-proteins
#13
Mary C Wallingford, Jacob Hiller, Kun Zhang, Jesse Mager
Yinyang1 (YY1) participates in protein-DNA, protein-RNA, and protein-protein interactions and regulates developmental processes and disease mechanisms. YY1 interactions regulate a range of important biological functions, including oocyte maturation, epithelial to mesenchymal transition, and vascular endothelial growth factor (VEGF) signaling. We tested the hypothesis that YY1 is required for inner cell mass (ICM) lineage commitment during preimplantation development. In this study, we document gene expression patterns and protein localization of key transcription factors in Yy1 global, tissue-specific, and dsRNA-mediated knockout/down embryos...
July 6, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28676757/greater-cortical-thickness-in-elderly-female-yoga-practitioners-a-cross-sectional-study
#14
Rui F Afonso, Joana B Balardin, Sara Lazar, João R Sato, Nadja Igarashi, Danilo F Santaella, Shirley S Lacerda, Edson Amaro, Elisa H Kozasa
Yoga, a mind-body activity that requires attentional engagement, has been associated with positive changes in brain structure and function, especially in areas related to awareness, attention, executive functions and memory. Normal aging, on the other hand, has also been associated with structural and functional brain changes, but these generally involve decreased cognitive functions. The aim of this cross-sectional study was to compare brain cortical thickness (CT) in elderly yoga practitioners and a group of age-matched healthy non-practitioners...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28674509/acceptance-and-commitment-therapy-for-the-treatment-of-music-performance-anxiety-a-pilot-study-with-student-vocalists
#15
David G Juncos, Glenn A Heinrichs, Philip Towle, Kiera Duffy, Sebastian M Grand, Matthew C Morgan, Jonathan D Smith, Evan Kalkus
This study investigated the use of Acceptance and Commitment Therapy (ACT) as a treatment for music performance anxiety (MPA) in an uncontrolled pilot design. ACT is a newer, "third-wave" therapy that differs from previous MPA treatments, because its goal is not to reduce symptoms of MPA. Rather, ACT aims to enhance psychological flexibility in the presence of unwanted symptoms through the promotion of six core processes collectively known as the ACT "Hexaflex." A small group of student vocalists (N = 7) from an elite choral college were recruited using objective criteria for evaluating MPA...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28670311/what-is-the-molecular-signature-of-mind-body-interventions-a-systematic-review-of-gene-expression-changes-induced-by-meditation-and-related-practices
#16
REVIEW
Ivana Buric, Miguel Farias, Jonathan Jong, Christopher Mee, Inti A Brazil
There is considerable evidence for the effectiveness of mind-body interventions (MBIs) in improving mental and physical health, but the molecular mechanisms of these benefits remain poorly understood. One hypothesis is that MBIs reverse expression of genes involved in inflammatory reactions that are induced by stress. This systematic review was conducted to examine changes in gene expression that occur after MBIs and to explore how these molecular changes are related to health. We searched PubMed throughout September 2016 to look for studies that have used gene expression analysis in MBIs (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28666186/eeg-correlates-of-cognitive-time-scales-in-the-necker-zeno-model-for-bistable-perception
#17
J Kornmeier, E Friedel, M Wittmann, H Atmanspacher
The Necker-Zeno model of bistable perception provides a formal relation between the average duration of meta-stable percepts (dwell times T) of ambiguous figures and two other basic time scales (t0, ΔT) underlying cognitive processing. The model predicts that dwell times T covary with t0, ΔT or both. We tested this prediction by exploiting that observers, in particular experienced meditators, can volitionally control dwell times T. Meditators and non-meditators observed bistable Necker cubes either passively or tried to hold their current percept...
June 27, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28665541/feasibility-of-the-mobile-mindfulness-based-stress-reduction-for-breast-cancer-mmbsr-bc-program-for-symptom-improvement-among-breast-cancer-survivors
#18
Cecile A Lengacher, Richard R Reich, Sophia Ramesar, Carissa B Alinat, Manolete Moscoso, Lakeshia Cousin, Victoria R Marino, Maya N Elias, Carly L Paterson, Carmen S Rodriguez, Hsiao-Lan Wang, Kevin E Kip, Hongdao Meng, Jong Y Park
OBJECTIVE: The purpose of this pilot study was to test the feasibility of delivering the mobile Mindfulness-Based Stress Reduction for Breast Cancer (mMBSR(BC)) program using an iPad and to evaluate its impact on symptom improvement. METHODS: A single group, pre-posttest design was implemented among female stages 0-III breast cancer survivors (BCS) who completed treatment. Data were collected at baseline and week 6 on measures of psychological and physical symptoms and quality of life...
June 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28663069/meditation-is-associated-with-increased-brain-network-integration
#19
Remko van Lutterveld, Edwin van Dellen, Prasanta Pal, Hua Yang, Cornelis Jan Stam, Judson Brewer
INTRODUCTION: This study aims to identify novel quantitative EEG measures associated with mindfulness meditation. As there is some evidence that meditation is associated with higher integration of brain networks, we focused on EEG measures of network integration. METHODS: Sixteen novice meditators and sixteen experienced meditators participated in the study. Novice meditators performed a basic meditation practice that supported effortless awareness, which is an important quality of experience related to mindfulness practices, while their EEG was recorded...
June 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/28662502/microrna-133b-ameliorates-allergic-inflammation-and-symptom-in-murine-model-of-allergic-rhinitis-by-targeting-nlrp3
#20
Lifeng Xiao, Li Jiang, Qi Hu, Yuru Li
BACKGROUND: Emerging evidences indicate that post-transcriptional regulation by microRNAs is critical in allergic rhinitis (AR) pathogenesis. MircroRNA-133b (miR-133b) was recently suggested as a potential predictor of AR. However, the in vivo effect of miR-133b on AR is unclear. METHODS: AR model was established in BALB/c mice by intraperitoneal sensitization and intranasal challenge with ovalbumin (OVA). MiR-133b agomir was then intranasally administrated to mice after OVA challenge for another 7 days...
June 26, 2017: Cellular Physiology and Biochemistry
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