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https://www.readbyqxmd.com/read/29052054/suppression-of-the-toll-like-receptor-7-dependent-type-i-interferon-production-pathway-by-autophagy-resulting-from-enterovirus-71-and-coxsackievirus-a16-infections-facilitates-their-replication
#1
Jie Song, Yajie Hu, Jiaqi Li, Huiwen Zheng, Jingjing Wang, Lei Guo, Haijng Shi, Longding Liu
Toll-like receptors (TLRs) act as molecular sentinels, detecting invading viral pathogens and triggering host innate immune responses, including autophagy. However, many viruses have evolved a series of strategies to manipulate autophagy for their own benefit. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16), as the primary agents causing hand, foot and mouth disease (HFMD), can induce autophagy leading to their replication. Therefore, the objective of this study was to investigate whether enhanced viral replication caused by autophagy in EV71 and CA16 infections was associated with a TLR-related signaling pathway...
October 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29039681/complementary-and-alternative-medicine-services-in-the-military-health-system
#2
Patricia M Herman, Melony E Sorbero, Ann C Sims-Columbia
OBJECTIVES: Surveys of military personnel indicate substantial use of complementary and alternative medicine (CAM) that possibly exceeds use in the general U.S. POPULATION: Although military treatment facilities (MTFs) are known to offer CAM, surveys do not indicate where service members receive this care. This study offers a comprehensive system-wide accounting of the types of CAM offered across the military health system (MHS), the conditions for which it is used, and its level of use...
October 17, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29033783/the-mechanisms-of-psychedelic-visionary-experiences-hypotheses-from-evolutionary-psychology
#3
Michael J Winkelman
Neuropharmacological effects of psychedelics have profound cognitive, emotional, and social effects that inspired the development of cultures and religions worldwide. Findings that psychedelics objectively and reliably produce mystical experiences press the question of the neuropharmacological mechanisms by which these highly significant experiences are produced by exogenous neurotransmitter analogs. Humans have a long evolutionary relationship with psychedelics, a consequence of psychedelics' selective effects for human cognitive abilities, exemplified in the information rich visionary experiences...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29025788/brief-mindfulness-meditation-for-depression-and-anxiety-symptoms-in-patients-undergoing-hemodialysis-a-pilot-feasibility-study
#4
Zoë Thomas, Marta Novak, Susanna Gabriela Torres Platas, Maryse Gautier, Angela Potes Holgin, Rebecca Fox, Marilyn Segal, Karl J Looper, Mark Lipman, Steven Selchen, Istvan Mucsi, Nathan Herrmann, Soham Rej
BACKGROUND AND OBJECTIVES: Up to 50% of patients undergoing hemodialysis suffer from symptoms of depression and/or anxiety. Access to traditional pharmacotherapies and psychotherapies for depression or anxiety in this patient population has been inadequate. The objective of this study was to investigate the feasibility and effectiveness of brief mindfulness meditation intervention for patients on hemodialysis with depression and anxiety symptoms. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study was a randomized, controlled, assessor-blinded trial conducted in an urban hemodialysis unit...
October 12, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29025275/complementary-and-alternative-medicine-use-in-minority-and-medically-underserved-oncology-patients-assessment-and-implications
#5
Desiree Jones, Lorenzo Cohen, Alyssa G Rieber, Diana Urbauer, Bryan Fellman, Michael J Fisch, Arlene Nazario
INTRODUCTION: Complementary and alternative medicine (CAM) use in minority and medically underserved oncology patients is not well documented. We assessed knowledge and utilization of CAM in a sample of these patients receiving treatment at an urban community hospital. METHODS: Patients with cancer were interviewed using an electronic application that depicted specific CAM therapies. Patients were questioned on their knowledge and utilization of therapies, deterrents to use, and interest in using these therapies if they were made available...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29025117/preliminary-investigation-of-workplace-provided-compressed-mindfulness-based-stress-reduction-with-pediatric-medical-social-workers
#6
Kelly Trowbridge, Lisa Mische Lawson, Stephanie Andrews, Jodi Pecora, Sabra Boyd
Mindfulness practices, including mindfulness meditation, show promise for decreasing stress among health care providers. This exploratory study investigates the feasibility of a two-day compressed mindfulness-based stress reduction (cMBSR) course provided in the hospital workplace with pediatric health care social workers. The standard course of Jon Kabat-Zinn's MBSR requires a participant commitment to eight weeks of instruction consisting of one 2.5-hour-per-week class, a single day retreat, and 45 minutes of practice for six of seven days each week...
September 8, 2017: Health & Social Work
https://www.readbyqxmd.com/read/29025059/mindfulness-for-chronic-low-back-pain-a-qualitative-analysis
#7
José G Luiggi-Hernandez, Jean Woo, Megan Hamm, Carol M Greco, Debra K Weiner, Natalia E Morone
Objective: Mindfulness is a nonpharmacologic mind-body therapy that has been shown to be effective in older adults with chronic low back pain (cLBP). There are few first-person accounts in the literature that describe the older adult experience and perspective while learning mindfulness and meditation to treat pain. The objective of this study was to investigate dominant themes present in the experiences of older adults applying mindfulness and meditation to cope with cLBP. Design: Qualitative analysis of four focus groups...
August 16, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29022737/implementation-of-an-integrative-medicine-treatment-program-at-a-veterans-health-administration-residential-mental-health-facility
#8
Melinda A Gaddy
A 4-week interdisciplinary integrative medicine program was recently added to the core treatment offerings for veterans participating in the Mental Health Residential Rehabilitation Program at the Dwight D. Eisenhower Veterans Affairs Medical Center. The new integrative medicine program teaches veterans about using meditative practices, nutrition, creative expression, tai chi, hatha yoga, sensory and breathing techniques, and lifestyle changes to enhance well-being. The groups are run by professionals from a variety of disciplines including recreation therapy, art therapy, occupational therapy, psychology, and nutrition...
October 12, 2017: Psychological Services
https://www.readbyqxmd.com/read/29022034/mindfulness-a-new-paradigm-of-psychosocial-care-in-the-palliative-care-setting-in-southeast-asia
#9
Seng Beng Tan, David Paul Capelle, Nor Zuraida Zainal, Ee Jane Lim, Ee Chin Loh, Chee Loong Lam
Alleviation of suffering in palliative care needs a combination of good symptom control and psychosocial care. The capacity of mindfulness to promote psychological flexibility opens up possibilities of creating a paradigm shift that can potentially change the landscape of psychosocial care. In this review, we attempt to introduce 4 methods to establish mindfulness based on 'The Discourse on the Foundations of Mindfulness', a core text of Theravada Buddhism, followed by a brief comparison of the concepts and practices of mindfulness in different cultures and religions in Southeast Asia...
September 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29020861/psilocybin-occasioned-mystical-type-experience-in-combination-with-meditation-and-other-spiritual-practices-produces-enduring-positive-changes-in-psychological-functioning-and-in-trait-measures-of-prosocial-attitudes-and-behaviors
#10
Roland R Griffiths, Matthew W Johnson, William A Richards, Brian D Richards, Robert Jesse, Katherine A MacLean, Frederick S Barrett, Mary P Cosimano, Maggie A Klinedinst
Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduring changes in traits. This study administered psilocybin to participants who undertook a program of meditation/spiritual practices. Healthy participants were randomized to three groups (25 each): (1) very low-dose (1 mg/70 kg on sessions 1 and 2) with moderate-level ("standard") support for spiritual-practice (LD-SS); (2) high-dose (20 and 30 mg/70 kg on sessions 1 and 2, respectively) with standard support (HD-SS); and (3) high-dose (20 and 30 mg/70kg on sessions 1 and 2, respectively) with high support for spiritual practice (HD-HS)...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29017568/polychlorinated-biphenyls-and-depression-cross-sectional-and-longitudinal-investigation-of-a-dopamine-related-neurochemical-path-in-the-german-helpcb-surveillance-program
#11
Petra Maria Gaum, Monika Gube, Thomas Schettgen, Franziska Maria Putschögl, Thomas Kraus, Bruno Fimm, Jessica Lang
BACKGROUND: Exposure to polychlorinated biphenyls (PCBs) is associated with depressive symptomatology. A cause of depressive symptoms is a disturbance in the neurotransmitter system of dopamine (DA). Animal as well as human studies report that PCBs can influence the DA system. This study examined whether PCB-related depressive symptoms are affected by DA metabolites in humans with high PCB body burden. METHODS: This study is part of the German HELPcB surveillance program (Health Effects in high Level exposure to PCB) for occupationally exposed workers and their relatives...
October 10, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29016274/mind-the-hype-a-critical-evaluation-and-prescriptive-agenda-for-research-on-mindfulness-and-meditation
#12
Nicholas T Van Dam, Marieke K van Vugt, David R Vago, Laura Schmalzl, Clifford D Saron, Andrew Olendzki, Ted Meissner, Sara W Lazar, Catherine E Kerr, Jolie Gorchov, Kieran C R Fox, Brent A Field, Willoughby B Britton, Julie A Brefczynski-Lewis, David E Meyer
During the past two decades, mindfulness meditation has gone from being a fringe topic of scientific investigation to being an occasional replacement for psychotherapy, tool of corporate well-being, widely implemented educational practice, and "key to building more resilient soldiers." Yet the mindfulness movement and empirical evidence supporting it have not gone without criticism. Misinformation and poor methodology associated with past studies of mindfulness may lead public consumers to be harmed, misled, and disappointed...
September 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29016240/reiterated-concerns-and-further-challenges-for-mindfulness-and-meditation-research-a-reply-to-davidson-and-dahl
#13
Nicholas T Van Dam, Marieke K van Vugt, David R Vago, Laura Schmalzl, Clifford D Saron, Andrew Olendzki, Ted Meissner, Sara W Lazar, Jolie Gorchov, Kieran C R Fox, Brent A Field, Willoughby B Britton, Julie A Brefczynski-Lewis, David E Meyer
In response to our article, Davidson and Dahl offer commentary and advice regarding additional topics crucial to a comprehensive prescriptive agenda for future research on mindfulness and meditation. Their commentary raises further challenges and provides an important complement to our article. More consideration of these issues is especially welcome because limited space precluded us from addressing all relevant topics. While we agree with many of Davidson and Dahl's suggestions, the present reply (a) highlights reasons why the concerns we expressed are still especially germane to mindfulness and meditation research (even though those concerns may not be entirely unique) and (b) gives more context to other issues posed by them...
September 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29016238/outstanding-challenges-in-scientific-research-on-mindfulness-and-meditation
#14
Richard J Davidson, Cortland J Dahl
Van Dam et al. raise a number of critical issues in contemporary research on mindfulness and meditation and offer a prescriptive agenda for future work in this area. While we agree with all of the key points made in their article, there are a number of important issues omitted that are central to a comprehensive agenda for future research in this area. This commentary highlights five key points: (a) Many of the key methodological issues the article raises are not specific to research on mindfulness; (b) contemplative practices are varied, and the landscape of modern scientific research has evolved to focus almost exclusively on one or two types of practice to the exclusion of other forms of practice that are potentially highly impactful;...
September 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28989550/emotion-regulation-mediates-the-associations-of-mindfulness-on-symptoms-of-depression-and-anxiety-in-the-general-population
#15
Laura Freudenthaler, Josephine D Turba, Ulrich S Tran
In the last decade, clinical research on mindfulness and its positive effects on depression and anxiety have gained increased interest. Emotion regulation mediates the effects of mindfulness on mental health in clinical samples and among meditators. The present study examined whether these associations also generalize to the general population. Multi-group structural equation models tested with a sample of 853 adults whether difficulties in emotion regulation mediated the associations between overall mindfulness in addition to the Observe facet with symptoms of depression and anxiety and whether associations were similar among men and women...
2017: Mindfulness
https://www.readbyqxmd.com/read/28985918/longitudinal-examination-of-social-and-environmental-influences-on-motivation-for-physical-activity
#16
Elizabeth A Richards, Meghan McDonough, Rong Fu
BACKGROUND: Physical activity behavior is influenced by numerous factors including motivation, social interactions, and the walkability of the environment. AIM: To examine how social contexts and environmental features affect physical activity motivational processes across time. METHODS: Participants (N=104) completed 3 monthly online surveys assessing self-determination theory constructs, social partners in physical activity, neighborhood walkability, and weekly physical activity...
October 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28985151/a-randomized-pilot-study-of-a-phone-based-mindfulness-and-weight-loss-program
#17
Kelly M Carpenter, Katrina A Vickerman, Erica E Salmon, Harold S Javitz, Elissa S Epel, Jennifer C Lovejoy
This study evaluated the feasibility and efficacy of integrating mindfulness training into a phone-based weight loss program to improve outcomes in those with high levels of emotional eating. Participants were 75 enrollees into an employer-sponsored weight loss program who reported high levels of overeating in response to thoughts and feelings. Seventy-five overweight and obese participants (92% female, 65% Caucasian, aged 26 to 68) were randomized to the new mindfulness weight loss program (n = 50) or the standard behavioral weight loss program (n = 25)...
October 6, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28981919/mind-body-therapies-in-individuals-with-dementia-an-integrative-review
#18
Joel G Anderson, Carol E Rogers, Ann Bossen, Ingelin Testad, Karen M Rose
Mind-body therapies frequently derive from Eastern philosophies and are becoming increasingly popular. These therapies, such as meditation, yoga, tai chi, qigong, biofield therapies, and guided imagery, have many reported benefits for improving symptoms and physiological measures associated with various chronic diseases. However, clinical research data concerning the effectiveness of these practices in individuals with dementia have not been evaluated using a synthesis approach. Thus, an integrative review was conducted to evaluate studies examining the efficacy of mind-body therapies as supportive care modalities for management of symptoms experienced by individuals with dementia...
October 5, 2017: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/28976220/private-speech-in-simultaneous-and-early-spanish-english-bilinguals
#19
Alfredo Ardila, Kate Benettieri, Yoandra Church, Angela Orozco, Carlos Saucedo
This study analyzed private speech in a group of sixty Spanish-English bilinguals. A Private Speech Questionnaire including questions about seven different conditions, that is, spiritual thinking (e.g., praying, meditating), dreaming, thinking, problem-solving, recalling past events, recalling information, and dealing with stress, was designed. Furthermore, the sample was divided into two subgroups: born in the United States (simultaneous bilinguals) and born outside the United States but arriving to the country before the age of 10 (early successive bilinguals)...
October 4, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28976032/dna-methylation-patterns-of-genes-related-to-immune-response-in-the-different-clinical-forms-of-oral-lichen-planus
#20
Aline Fernanda Cruz, Renata Gonçalves de Resende, Júlio César Tanos de Lacerda, Núbia Braga Pereira, Leonardo Augusto Melo, Marina Gonçalves Diniz, Carolina Cavalieri Gomes, Ricardo Santiago Gomez
BACKGROUND: The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognized. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-meditated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus...
October 4, 2017: Journal of Oral Pathology & Medicine
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