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https://www.readbyqxmd.com/read/28938726/preparing-interventional-fellows-for-advanced-training-in-structural-heart-disease-interventions
#1
Ankur Kalra, Ankur Kalra, Ali Andalib, Ronnie Ramadan, Abdul Moiz Hafiz, Marie-France Poulin, Hector Tamez, Duane S Pinto, Jeffrey J Popma
No abstract text is available yet for this article.
March 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28938406/ct-derived-body-fat-distribution-and-incident-cardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#2
Morgana L Mongraw-Chaffin, Matthew A Allison, Gregory L Burke, Michael H Criqui, Kunihiro Matsushita, Pamela Ouyang, Ravi V Shah, Christina M Shay, Cheryl A M Anderson
Background: Visceral fat has been shown to be associated with increased cardiometabolic risk, but the role of subcutaneous fat remains unclear, and evidence from diverse populations is lacking. We hypothesized that visceral, but not subcutaneous fat, would be independently associated with incident cardiovascular disease and all-cause mortality. Methods: Among 1,910 participants from the Multi-Ethnic Study of Atherosclerosis with abdominal fat measurements from computed tomography (CT) scans and followed for an average of 9...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937981/cognitive-function-in-patients-with-stable-coronary-heart-disease-related-cerebrovascular-and-cardiovascular-responses
#3
Mathieu Gayda, Vincent Gremeaux, Louis Bherer, Martin Juneau, Joffrey Drigny, Olivier Dupuy, Gabriel Lapierre, Véronique Labelle, Annik Fortier, Anil Nigam
Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and [Formula: see text] peak compared to age-matched and young healthy control subjects. Twenty-two young healthy controls (YHC), 20 age-matched old healthy controls (OHC) and 25 patients with stable CHD were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28937939/trend-and-predictors-of-unplanned-hospitalization-of-older-patients-during-the-first-year-after-admission-into-a-home-medical-service
#4
Rakhi Mittal, C S Tan, W Y Tham, Lydia P S Seong, Tl Tan, G Choon-Huat Koh
The primary aim was to determine the trend and predictors of unplanned hospitalization of home medical patients. Records of 1,069 patients were obtained from the medical records. Out of 1069, we analyzed 512 patients who had utilized services across all four quarters in the first year of admission. There was a significant decline in unplanned hospitalization between the first two quarters. The potential risk factors were male sex [IRR (95% CI), 1.29 (0.99-1.67)], chronic pulmonary disease [1.53 (1.08-2.16)], dementia [1...
September 22, 2017: Home Health Care Services Quarterly
https://www.readbyqxmd.com/read/28937531/median-effective-dose-of-intranasal-dexmedetomidine-sedation-for-transthoracic-echocardiography-examination-in-postcardiac-surgery-and-normal-children-an-up-and-down-sequential-allocation-trial
#5
Yang Liu, Qing Yu, Mang Sun, Shangyingying Li, Jing Zhang, Yao Lei, Chaofeng Li, Fei Yang, Shengfen Tu
BACKGROUND: Dexmedetomidine (DEX) has been used for sedation in young infants and children undergoing transthoracic echocardiography (TTE). The median effective dose of intranasal DEX has not been described for postcardiac surgery children. Postcardiac surgery children could require more DEX to achieve satisfactory sedation for TTE examination than children suspected of congenital heart disease. OBJECTIVES: To study whether postcardiac surgery children need a larger dose of DEX for TTE than normal children...
September 20, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28937442/orally-active-epoxyeicosatrienoic-acid-analogs
#6
William B Campbell, John D Imig, James M Schmitz, John R Falck
Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory cell adhesion and cytokine release. Renal EETs promote sodium excretion and vasodilation to decrease hypertension. Cardiac EETs reduce infarct size after ischemia-reperfusion injury and decrease fibrosis and inflammation in heart failure. In diabetes, EETs improve insulin sensitivity, increase glucose tolerance, and reduce the renal injury...
September 19, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28937256/evaluation-of-left-and-right-ventricular-systolic-and-diastolic-electromechanical-synchrony-in-older-people-a-population-based-observational-study
#7
R Laszlo, H Konz, K Kunz, D Dallmeier, J Klenk, M Denkinger, W Koenig, D Rothenbacher, J M Steinacker
It is unknown whether physiological ageing also goes along with electromechanical asynchrony of contraction. Aim of the study was to evaluate synchrony of contraction in older people with ("non-healthy") or without ("healthy") evidence for structural cardiac disease. In 547 persons (age 76.7+/-5.5 years, 306 male, 241 female) recruited from a population-based cohort of the ActiFE-Um study including a random sample of people >/= 65 years old living in the region of Ulm, Germany, various PW- and TDI-Doppler based markers for asynchrony were obtained by echocardiography...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937039/safety-and-necessity-of-antiplatelet-therapy-on-patients-underwent-endovascular-aortic-repair-with-both-stanford-type-b-aortic-dissection-and-coronary-heart-disease
#8
Rui-Xia He, Lei Zhang, Tie-Nan Zhou, Wen-Jie Yuan, Yan-Jie Liu, Wen-Xia Fu, Quan-Min Jing, Hai-Wei Liu, Xiao-Zeng Wang
BACKGROUND: Acute aortic dissection is known as the most dangerous aortic disease, with management and prognosis determined as the disruption of the medial layer provoked by intramural bleeding. The objective of this study was to evaluate the safety and necessity of antiplatelet therapy on patients with Stanford Type B aortic dissection (TBAD) who underwent endovascular aortic repair (EVAR). METHODS: The present study retrospectively analyzed 388 patients with TBAD who underwent EVAR and coronary angiography...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936993/coarctation-of-the-aorta-with-aortic-arch-hypoplasia-midterm-outcomes-of-aortic-arch-reconstruction-with-autologous-pulmonary-artery-patch
#9
Zhi-Ling Ma, Jun Yan, Shou-Jun Li, Zhong-Dong Hua, Fu-Xia Yan, Xu Wang, Qiang Wang
BACKGROUND: Coarctation of the aorta (CoA) with aortic arch hypoplasia (AAH) is a relatively common congenital heart disease in clinical practice. Nonetheless, the corrective surgical technique for infants and children is a clinical problem that remains controversial. In this study, we sought to evaluate the surgical effects of aortic arch (AA) reconstruction with coarctation resection and aortoplasty with autologous pulmonary artery patch for infants and young children with CoA and AAH...
September 21, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936832/-clinical-medication-characteristics-of-shuxuening-injection-in-treatment-of-cerebral-infarction-research-based-on-registration
#10
Jun-Jie Jiang, Yan-Ming Xie, Yin Zhang, Yi-Kai Zhang, Zuo-Ming Wang, Bing Han
To understand the medication characteristics of Xingxue@Shuxuening solutions in the real world, multi-center, large-sample-size registration design method is adopted in this study. Between October 2012 and October 2015, hospitalized patients in 27 medical institutions who used Shuxuening and diagnosed as cerebral infarction were observed, including their general information, diagnosis information and medication information. Totally 9 473 cases of cerebral infarction were included, with old people as the majority, and males were slightly more men than females; they were complicated with coronary heart disease, vertebrobasilar artery insufficiency, transient brain ischemia and other cerebrovascular diseases; the medication duration was mostly within 14 days; the dosage was mainly 8-20 mL; 0...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936747/exosomes-outlook-for-future-cell-free-cardiovascular-disease-therapy
#11
Bahar Barani, Sheeja Rajasingh, Johnson Rajasingh
Cardiovascular diseases are the number one cause of death globally with an estimated 7.4 million people dying from coronary heart disease. Studies have been conducted to identify the therapeutic utility of exosomes in many diseases, including cardiovascular diseases. It has been demonstrated that exosomes are immune modulators, can be used to treat cardiac ischemic injury, pulmonary hypertension and many other diseases, including cancers. Exosomes can be used as a biomarker for disease and cell-free drug delivery system for targeting the cells...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936746/therapeutic-effects-of-ischemic-preconditioned-exosomes-in-cardiovascular-diseases
#12
Shengguang Ding, Zhiqing Fan, Che Lin, Qiying Dai, Jinzhe Zhou, Haitao Huang, Yiming Xu, Chongjun Zhong
Despite years of researches, cardiovascular disease (CVD) remains the most common cause of death around the world. Lots of studies showed that by pretreating with short nonfatal ischemia in in situ organ or distant organ, one could develop tolerance to the following fatal ischemia. The process is called ischemic preconditioning (IPC). IPC prepare the heart for damage by producing inflammatory signals, miRNA, neuro system stimulation and exosomes. Among them, exosomes have been gaining increasing interest since it is characterized by its capability to carry information and its specific ligand-receptor system...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936744/cardiac-telocyte-derived-exosomes-and-their-possible-implications-in-cardiovascular-pathophysiology
#13
Mirca Marini, Lidia Ibba-Manneschi, Mirko Manetti
Among cardiac interstitial cells, the recently described telocytes (TCs) display the unique ability to build a supportive three-dimensional network formed by their very long and thin prolongations named telopodes. Cardiac TCs are increasingly regarded as pivotal regulators in intercellular signaling with multiple cell types, such as cardiomyocytes, stem/progenitor cells, microvessels, nerve endings, fibroblasts and immune cells, thus converting the cardiac stromal compartment into an integrated system that may drive either heart development or maintenance of cardiac homeostasis in post-natal life...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936743/therapeutic-potential-of-hematopoietic-stem-cell-derived-exosomes-in-cardiovascular-disease
#14
Jana Radosinska, Monika Bartekova
As other stem cells, hematopoietic stem cells (HSCs) are able to produce extracellular vesicles (EVs) including exosomes and microvesicles. This chapter summarizes the knowledge about the production of EVs by the HSCs, their role in the intercellular communication, and will discuss the cargo of these EVs as well as protective effects of HSCs-derived exosomes and microvesicles in cardiovascular diseases (CVD). Available data showed that cardioprotective action of injected HSCs could not be explained by direct transdifferentiationof injected cells into the cardiomyocytes, this effect is suggested to be mediated via paracrine communication (by EVs) between donor and recipient cells...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936742/cardiac-progenitor-cell-derived-exosomes-as-cell-free-therapeutic-for-cardiac-repair
#15
E A Mol, M J Goumans, J P G Sluijter
Cardiac progenitor cells (CPCs) have emerged as potential therapy to improve cardiac repair and prevent damage in cardiac diseases. CPCs are a promising cell source for cardiac therapy as they can generate all cardiovascular lineages in vitro and in vivo. Originating from the heart itself, CPCs may be destined to activate endogenous repair mechanisms. These CPCs release paracrine molecules that are able to stimulate cardiac repair mechanisms, including stimulation of vessel formation and inhibition of cardiomyocyte apoptosis...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936741/exosomes-derived-from-embryonic-stem-cells-as-potential-treatment-for-cardiovascular-diseases
#16
Yao-Hua Song, Lianbo Shao, Yu Zhang, Jin Zhou, Bin Liu, Xiangbin Pan, Yong-Jian Geng, Xi-Yong Yu, Yangxin Li
Cardiovascular diseases resulting from ischemic heart diseases remain to be the main causes of heart failure and death despite significant advances in medical treatment. The development of new therapies for heart failure is thus required to improve the outcome in these patients, and this has led to the development of cell-based therapies. Animal studies showed interesting results using various cell types. Some stem cell based therapies have been tested in clinical trials. Although the results were encouraging, challenges remain...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936740/therapeutic-effects-of-mesenchymal-stem-cell-derived-exosomes-in-cardiovascular-disease
#17
Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Hiroaki Nishimatsu
Mesenchymal stem cells (MSCs) are multipotent stem cells that reside in various organs. They have the capacity to differentiate into various cell types, including cardiomyocytes, vascular endothelial cells, and vascular smooth muscle cells. Among the various MSCs, bone marrow-derived MSCs (BMMSCs) have been widely used for treating acute myocardial infarction (AMI) and ischemic heart failure (IHF) in preclinical and clinical studies. Although the beneficial effects of BMMSCs in treating AMI and IHF were originally attributed to their capacity to differentiate into cardiac cell types, recent evidence suggests that the differentiation capacity of BMMSCs appears to be minimal and that BMMSCs exert cardioprotective effects by secreting paracrine factors...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936737/peripartum-cardiomyopathy-do-exosomes-play-a-role
#18
Huanyu Gu, Qiying Dai, Zhuyuan Liu, Hongbao Wang, Jianhua Yao, Lei Zhou
Peripartum cardiomyopathy (PPCM) refers to irreversible cardiomyocyte damage that occurs during the last month of pregnancy, or within 5 months after giving birth. It is characterized by systolic heart failure. This life-threatening condition is relatively uncommon, but the incidence has been climbing up. Because of its high mortality, it is crucial for physicians to have high suspicious for the disease. Studies have been done to search into specific lab test and treatment for PPCM. Therapies like anti-viral, anti-inflammatory and immunosuppression regimen have been explored...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936736/pathological-effects-of-exosomes-in-mediating-diabetic-cardiomyopathy
#19
Esam S B Salem, Guo-Chang Fan
Diabetic subjects are at risk of developing cardiovascular disease, which accounts for 60-80% of diabetes-related mortality. Atherosclerosis is still considered as a leading cause of heart failure in diabetic patients, but it could also be an intrinsic and long-term effect of contractile cardiac cells malfunction, known as diabetic cardiomyopathy (DCM). Pathologically, this cardiac dysfunction is manifested by inflammation, apoptosis, fibrosis, hypertrophy and altered cardiomyocytes metabolism. However, the underlying molecular mechanisms of DCM pathophysiology are not clearly understood...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936735/dual-behavior-of-exosomes-in-septic-cardiomyopathy
#20
Valter Vinícius Silva Monteiro, Jordano Ferreira Reis, Rafaelli de Souza Gomes, Kely Campos Navegantes, Marta Chagas Monteiro
Sepsis is one of the main causes of ICU hospitalization worldwide, with a high mortality rate, and is associated with a large number of comorbidities. One of the main comorbidities associated with sepsis is septic cardiomyopathy. This process occurs mainly due to mechanisms of damage in the cardiovascular system that will lead to changes in cardiovascular physiology, such as decreased Ca(2+) response, mitochondrial dysfunction and decreased β-adrenergic receptor response. Within this process the exosomes play an important role in the pathophysiology of this disease, in which the exosomal content is related to mechanisms that will trigger its development...
2017: Advances in Experimental Medicine and Biology
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