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https://www.readbyqxmd.com/read/29786848/annual-report-to-the-nation-on-the-status-of-cancer-part-i-national-cancer-statistics
#1
Kathleen A Cronin, Andrew J Lake, Susan Scott, Recinda L Sherman, Anne-Michelle Noone, Nadia Howlader, S Jane Henley, Robert N Anderson, Albert U Firth, Jiemin Ma, Betsy A Kohler, Ahmedin Jemal
BACKGROUND: The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate to provide annual updates on cancer occurrence and trends in the United States. METHODS: Incidence data were obtained from the CDC-funded and NCI-funded population-based cancer registry programs and compiled by NAACCR. Data on cancer deaths were obtained from the National Center for Health Statistics National Vital Statistics System...
May 22, 2018: Cancer
https://www.readbyqxmd.com/read/29786817/targeted-cardiopulmonary-resuscitation-training-focused-on-the-family-members-of-high-risk-patients-at-a-regional-medical-center-a-comparison-between-family-members-of-high-risk-and-no-risk-patients
#2
Kap Su Han, Ji Sung Lee, Su Jin Kim, Sung Woo Lee
BACKGROUND: We developed a hospital-based cardiopulmonary resuscitation (CPR) training model focused on the target population (family members of patients with potential risks for cardiac arrest) and compared the outcome of CPR training between target and non-target populations for validity. METHODS: Family members of patients in training were divided into three groups on the basis of patients' diseases, as follows: 1) the cardio-specific (CS) risk group, including family members of patients with cardiac disease at risk of cardiac arrest; 2) the cardiovascular (CV) risk group, including family members of patients with risk factors for cardiovascular disease; and 3) the no-risk group...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786776/a-framework-for-image-based-modeling-of-acute-myocardial-ischemia-using-intramurally-recorded-extracellular-potentials
#3
Brett M Burton, Kedar K Aras, Wilson W Good, Jess D Tate, Brian Zenger, Rob S MacLeod
The biophysical basis for electrocardiographic evaluation of myocardial ischemia stems from the notion that ischemic tissues develop, with relative uniformity, along the endocardial aspects of the heart. These injured regions of subendocardial tissue give rise to intramural currents that lead to ST segment deflections within electrocardiogram (ECG) recordings. The concept of subendocardial ischemic regions is often used in clinical practice, providing a simple and intuitive description of ischemic injury; however, such a model grossly oversimplifies the presentation of ischemic disease-inadvertently leading to errors in ECG-based diagnoses...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786766/bacterial-dna-detected-on-pathologically-changed-heart-valves-using-16s-rrna-gene-amplification
#4
Miroslava Chalupova, Anna Skalova, Tomas Hajek, Lenka Geigerova, Dana Kralova, Pavel Liska, Hana Hecova, Jiri Molacek, Jaroslav Hrabak
Nowadays, dental diseases are one of the most common illnesses in the world. Some of them can lead to translocation of oral bacteria to the bloodstream causing intermittent bacteraemia. Therefore, a potential association between oral infection and cardiovascular diseases has been discussed in recent years as a result of adhesion of oral microbes to the heart valves. The aim of this study was to detect oral bacteria on pathologically changed heart valves not caused by infective endocarditis. In the study, patients with pathologically changed heart valves were involved...
May 22, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29786755/cardiac-progenitor-cell%C3%A2-derived-exosomes-promote-h9c2-cell-growth-via-akt-mtor-activation
#5
Shentang Li, Jie Jiang, Zuocheng Yang, Zhuoying Li, Xing Ma, Xin Li
Exosomes are cell‑derived vesicles released from a variety of mammalian cells that are involved in cell‑to‑cell signalling. It has been reported that cardiac progenitor cells (CPCs) derived from an adult heart are one of the most promising stem cell types for cardioprotection and repair. The mammalian target of rapamycin (mTOR) signalling pathway is a pivotal regulator in CPCs, therefore, CPC‑derived exosomes were used in the present study to investigate whether it can promote H9C2 cell growth through the protein kinase B (PKB, or Akt)/mTOR signalling pathway...
May 21, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29786749/long-noncoding-rna-myocardial-infarction%C3%A2-associated-transcript-is-associated-with-the-microrna%C3%A2-150%C3%A2-5p-p300-pathway-in-cardiac-hypertrophy
#6
Zhao Li, Yamin Liu, Xiaofan Guo, Guozhe Sun, Qun Ma, Ying Dai, Guangshuo Zhu, Yingxian Sun
In numerous diseases, abnormal expression of myocardial infarction‑associated transcript (MIAT) has been reported to be involved in cell proliferation, apoptosis and migration. However, whether this long non‑coding RNA MIAT has a regulatory effect on heart hypertrophy requires further investigation. To this end, the present study evaluated MIAT in hypertrophic cardiomyocytes in vitro and in vivo. Neonatal rat ventricular myocytes (NRVMs) were induced by isoproterenol (ISO) to create a cell hypertrophy model, and mice were intraperitoneally injected with ISO to establish an animal model...
May 21, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29786595/-genetically-determined-abnormal-electrical-activity-of-the-brain-and-the-heart
#7
Iwona Mańka-Gaca, Beata Łabuz-Roszak, Agnieszka Machowska-Majchrzak
Mutations leading to disorders within ion (mainly potassium and sodium) channels, have different degrees of expression in the brain and in the heart, which can cause simultaneous occurrence of disorders in both organs. This is manifested by the occurrence of epileptic seizures and cardiac electrical disturbances, further exacerbated by stimulation of autonomic structures within the central nervous system. In all patients with unclear paroxysmal disorders, and in those with unexplained sudden cardiac death, consideration should be given to the possibility of occurrence of genetically determined disorders in the ion channels...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786570/combination-of-metformin-and-pioglitazone-and-its-effect-in-treatment-of-comorbid-pathology
#8
Zlatoslava O Shaienko, Lyudmila Ye Bobyreva
OBJECTIVE: Introduction: The early development and high incidence of cardiovascular lesion in patients with type 2 diabetes mellitus is one of the most serious challenges for the diabetology worldwide. The aim: The purpose of the paper is to determine the dynamics of the insulin resistance indices in patients with type 2 diabetes mellitus concomitant with coronary heart disease in the combination therapy with metformin and pioglitazone during 3 and 6 months. PATIENTS AND METHODS: Materials and methods: 95 patients with type 2 diabetes mellitus and coronary heart disease have been treated and randomized into two groups: the comparison group (n=37), treated with metformin and sulfonylureas, and the study group (n=58), treated with metformin in combination with pioglitazone...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786560/microfabrication-of-liver-and-heart-tissues-for-drug-development
#9
REVIEW
Grace E Brown, Salman R Khetani
Drug-induced liver- and cardiotoxicity remain among the leading causes of preclinical and clinical drug attrition, marketplace drug withdrawals and black-box warnings on marketed drugs. Unfortunately, animal testing has proven to be insufficient for accurately predicting drug-induced liver- and cardiotoxicity across many drug classes, likely due to significant differences in tissue functions across species. Thus, the field of in vitro human tissue engineering has gained increasing importance over the last 10 years...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786536/percutaneous-coronary-and-structural-interventions-in-women-a-position-statement-from-the-eapci-women-committee
#10
Alaide Chieffo, Gill Louise Buchanan, Julinda Mehilli, Davide Capodanno, Vijay Kunadian, Anna Sonia Petronio, Ghada W Mikhail, Piera Capranzano, Nieves Gonzal, Nicole Karam, Stéphane Manzo-Silberman, Stefanie Schüpke, Robert A Byrne, Giuliana Capretti, Yolande Appelman, Marie-Claude Morice, Patrizia Presbitero, Maria Radu, Josepa Mauri
Several expert documents on sex-based differences in interventional outcomes are now available, however this is the first position paper from the EAPCI Women Committee discussing the potential influence of sex in the percutaneous treatment of coronary and structural heart disease. Despite the misconception that coronary artery disease is a 'man's disease', contemporary data shows a growing incidence in women. However, women are under-represented in randomised coronary clinical trials (~25%). The generalisation of such studies is therefore problematic in decision-making for females undergoing coronary intervention...
May 22, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29786408/impact-of-additional-tricuspid-valve-annuloplasty-in-tof-patients-undergoing-pulmonary-valve-replacement
#11
Sabrina Lueck, Eike Bormann, Kathrin Rellensmann, Sven Martens, Andreas Rukosujew
BACKGROUND: Many patients with tetralogy of Fallot (TOF) who underwent surgical correction of their congenital cardiac malformation during infancy develop right ventricular dysfunction and exercise intolerance in the long term. The right ventricle (RV) dilates due to the development of severe pulmonary regurgitation (and secondary tricuspid insufficiency). To reduce RV dilation and improve exercise tolerance pulmonary valve replacement (PVR) is the common therapeutic strategy. Whether concomitant tricuspid valve repair (TVR) is beneficial in these pure volume-overload conditions is still unknown...
May 22, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29786183/-hyperkalemia-as-a-limiting-factor-in-the-use-of-drugs-that-block-the-renin-angiotensin-aldosterone-system-raas
#12
Antonio Santoro, Marcora Mandreoli
Angiotensin-converting enzyme (ACE-I) inhibitors and ARBs have shown real efficacy in reducing blood pressure, proteinuria, in slowing the progression of chronic kidney disease (MRC) and in clinical improvement. in patients with heart failure, diabetes mellitus and ischemic heart disease. However, their use is limited by some side effects such as the increase in serum potassium (K), which can be particularly severe in patients with renal insufficiency. In the 23,000 patients followed by the PIRP project of the Emilia-Romagna Region, hyperkalaemia at the first visit (K> 5...
May 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29785959/common-carotid-artery-diameter-and-risk-of-cardiovascular-events-and-mortality-pooled-analyses-of-four-cohort-studies
#13
Sanaz Sedaghat, Thomas T van Sloten, Stéphane Laurent, Gérard M London, Bruno Pannier, Maryam Kavousi, Francesco Mattace-Raso, Oscar H Franco, Pierre Boutouyrie, M Arfan Ikram, Coen D A Stehouwer
Carotid arterial diameter enlargement is a manifestation of arterial remodeling and may be a risk factor for cardiovascular disease (CVD). We evaluated the association between carotid artery diameter and risk of stroke, coronary heart disease, CVD, and all-cause mortality and explored whether the associations could be explained by processes involved in arterial remodeling, that is, blood pressure-related media thickening, arterial stiffness, arterial wall stress, and atherosclerosis. We included 4887 participants (mean age 67±9 years; 54% women) from 4 cohort studies: Rotterdam Study, NEPHROTEST, Hoorn Study, and a study by Blacher et al...
May 21, 2018: Hypertension
https://www.readbyqxmd.com/read/29785957/associations-of-egg-consumption-with-cardiovascular-disease-in-a-cohort-study-of-0-5-million-chinese-adults
#14
Chenxi Qin, Jun Lv, Yu Guo, Zheng Bian, Jiahui Si, Ling Yang, Yiping Chen, Yonglin Zhou, Hao Zhang, Jianjun Liu, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li
OBJECTIVE: To examine the associations between egg consumption and cardiovascular disease (CVD), ischaemic heart disease (IHD), major coronary events (MCE), haemorrhagic stroke as well as ischaemic stroke. METHODS: During 2004-2008, over 0.5 million adults aged 30-79 years were recruited from 10 diverse survey sites in China. Participants were asked about the frequency of egg consumption and were followed up via linkages to multiple registries and active investigation...
May 21, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29785872/effect-evaluation-on-use-of-bedside-fiber-bronchoscope-in-treating-stroke-associated-pneumonia
#15
Qiu Han, Chun Chen, Hai-Qin Hu, Jun Shen, Guang Yang, Bin Chen, Lei Xia
Background The bedside fiber bronchoscope has been widely used in the diagnosis and treatment of respiratory disease. This study aims to assess the effect of using bedside fiber bronchoscope in sputum suction and alveolar lavage for treatment of stroke-associated pneumonia (SAP), compared with the use of conventional suction catheter. Methods One hundred and six patients with SAP were randomly divided into control group (n = 53) and experimental group (n = 53) for a controlled study. Patients in the two groups were conventionally treated with phlegm-resolving and anti-infective therapy...
May 22, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29785790/the-role-of-mirna-regulation-in-fetal-cardiomyocytes-cardiac-maturation-and-the-risk-of-heart-disease-in-adults
#16
Mitchell C Lock, Ross L Tellam, Kimberley J Botting, Kimberley C W Wang, Joseph B Selvanayagam, Doug A Brooks, Mike Seed, Janna L Morrison
Myocardial infarction is a primary contributor towards the global burden of cardiovascular disease. Rather than repairing the existing damage of myocardial infarction, current treatments only address the symptoms of the disease and reducing the risk of a secondary infarction. Cardiac regenerative capacity is dependent on cardiomyocyte proliferation, which concludes soon after birth in humans and precocial species such as sheep. Human fetal cardiac tissue has some ability to repair following tissue damage, whereas a fully matured human heart has minimal capacity for cellular regeneration...
May 22, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29785727/body-composition-profiling-in-the-uk-biobank-imaging-study
#17
Jennifer Linge, Magnus Borga, Janne West, Theresa Tuthill, Melissa R Miller, Alexandra Dumitriu, E Louise Thomas, Thobias Romu, Patrik Tunón, Jimmy D Bell, Olof Dahlqvist Leinhard
OBJECTIVE: This study aimed to investigate the value of imaging-based multivariable body composition profiling by describing its association with coronary heart disease (CHD), type 2 diabetes (T2D), and metabolic health on individual and population levels. METHODS: The first 6,021 participants scanned by UK Biobank were included. Body composition profiles (BCPs) were calculated, including abdominal subcutaneous adipose tissue, visceral adipose tissue (VAT), thigh muscle volume, liver fat, and muscle fat infiltration (MFI), determined using magnetic resonance imaging...
May 22, 2018: Obesity
https://www.readbyqxmd.com/read/29785706/goal-striving-stress-is-associated-with-chronic-kidney-disease-among-participants-in-the-jackson-heart-study
#18
Loretta R Cain, LáShauntá Glover, Bessie Young, Mario Sims
OBJECTIVE: Research that assesses the relationship between psychosocial factors and chronic kidney disease (CKD) among African Americans (AAs) is limited. Using the Jackson Heart Study (JHS) cohort data, we investigated the association of goal-striving stress (GSS)-the stress experienced from not reaching goals-with prevalent CKD among AAs. DESIGN: This was a cross-sectional analysis of JHS exam 1 data that assessed the relationship between GSS and CKD. SETTING AND PARTICIPANTS: We utilized a sample from the JHS (n = 4967), an AA sample of women and men, 35-84 years old from the Jackson, MS metro area...
May 21, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29785543/outcome-of-hospitalised-heart-failure-in-japan-and-the-united-kingdom-stratified-by-plasma-n-terminal-pro-b-type-natriuretic-peptide
#19
Yasuyuki Shiraishi, Toshiyuki Nagai, Shun Kohsaka, Ayumi Goda, Yuji Nagatomo, Atsushi Mizuno, Takashi Kohno, Alan Rigby, Keiichi Fukuda, Tsutomu Yoshikawa, Andrew L Clark, John G F Cleland
BACKGROUND: Mortality subsequent to a hospitalisation for heart failure is reported to be much lower in Japan than in the United Kingdom (UK). This could reflect differences in disease severity or in management. Accordingly, we directly compared patient backgrounds and outcomes between Japan and UK. METHODS: Consecutive patients admitted to academic hospitals in the UK and Japan with heart failure had a common set of variables, including plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP), collected during admission...
May 21, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29785271/right-ventricular-dysfunction-and-pulmonary-hypertension-a-neglected-presentation-of-thyrotoxicosis
#20
Carolina Shalini Singarayar, Foo Siew Hui, Nicholas Cheong, Goay Swee En
Thyrotoxicosis is associated with cardiac dysfunction; more commonly, left ventricular dysfunction. However, in recent years, there have been more cases reported on right ventricular dysfunction, often associated with pulmonary hypertension in patients with thyrotoxicosis. Three cases of thyrotoxicosis associated with right ventricular dysfunction were presented. A total of 25 other cases of thyrotoxicosis associated with right ventricular dysfunction published from 1994 to 2017 were reviewed along with the present 3 cases...
2018: Endocrinology, Diabetes & Metabolism Case Reports
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