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Gazzard glaucoma

Alexander C Day, David Cooper, Jennifer Burr, Paul J Foster, David S Friedman, Gus Gazzard, Jemaima Che-Hamzah, Tin Aung, Craig R Ramsay, Augusto Azuara-Blanco
BACKGROUND: To describe the surgical technique and refractive outcomes following clear lens extraction (CLE) in the Effectiveness, in Angle-closure Glaucoma, of Lens Extraction trial. METHODS: Review of prospectively collected data from a multicentre, randomised controlled trial comparing CLE and laser peripheral iridotomy. Eligible participants were ≥50 years old and newly diagnosed with (1) primary angle closure (PAC) with intraocular pressure above 30 mm Hg or (2) PAC glaucoma...
February 16, 2018: British Journal of Ophthalmology
A Garg, G Gazzard
Over the past two decades, selective laser trabeculoplasty (SLT) has increasingly become an established laser treatment used to lower intraocular pressure in open-angle glaucoma and ocular hypertensive patients. In this review we trace the origins of SLT from previous argon laser trabeculoplasty and review the current role it has in clinical practice. We outline future directions of SLT research and introduce emerging technologies that are further developing this intervention in the treatment paradigm of glaucoma...
January 5, 2018: Eye
Mitchell Lawlor, Ana Quartilho, Catey Bunce, Neil Nathwani, Emily Dowse, Debbie Kamal, Gus Gazzard
Purpose: We determined whether there is relative sparing of pupil function in glaucoma patients with normal pressures compared to those with high pressures. Methods: A cross-sectional study was done of 68 patients with primary open angle glaucoma (POAG): 38 had normal IOPs on all-day phasing before treatment (never >21 mm Hg), with confirmed progression of glaucomatous optic neuropathy (NTG) and 30 had glaucomatous optic neuropathy associated with elevated intraocular pressures (>25 mm Hg; HP-POAG)...
October 1, 2017: Investigative Ophthalmology & Visual Science
Evgenia Konstantakopoulou, Gus Gazzard, Victoria Vickerstaff, Yuzhen Jiang, Neil Nathwani, Rachael Hunter, Gareth Ambler, Catey Bunce
PURPOSE: The laser in glaucoma and ocular hypertension (LiGHT) trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior to initial treatment with topical medication for primary open angle glaucoma (POAG) or ocular hypertension (OHT). DESIGN: LiGHT is a prospective unmasked, multicentre, pragmatic, randomised controlled trial (RCT). PARTICIPANTS: 718 previously untreated patients with POAG or OHT were recruited at 6 UK centres between 2012 and 2014...
May 2018: British Journal of Ophthalmology
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Keith Barton, Richard Wormald, Stephen Morris, Rachael Hunter, Gary Rubin, Marta Buszewicz, Gareth Ambler, Catey Bunce
PURPOSE: The Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior to initial treatment with topical medication for primary open-angle glaucoma (POAG) or ocular hypertension (OHT). DESIGN: The LiGHT Trial is a prospective, unmasked, multicentre, pragmatic, randomised controlled trial. 718 previously untreated patients with POAG or OHT were recruited at six collaborating centres in the UK between 2012 and 2014...
May 2018: British Journal of Ophthalmology
Victoria Vickerstaff, Gareth Ambler, Catey Bunce, Wen Xing, Gus Gazzard
No abstract text is available yet for this article.
July 11, 2017: Trials
Jimmy T Le, Benjamin Rouse, Gus Gazzard
This is the protocol for a review and there is no abstract. The objectives are as follows: The primary objective is to assess the role of iridotomy-compared with observation-in the prevention of visual field loss for individuals who have primary angle closure or primary angle-closure glaucoma in at least one eye. We will also examine the role of iridotomy in the prevention of elevated intraocular pressure (IOP) in individuals with narrow angles (primary angle-closure suspect) in at least one eye.
2016: Cochrane Database of Systematic Reviews
Kuang Hu, Gus Gazzard, Catey Bunce, Richard Wormald
BACKGROUND: Glaucoma is the leading cause of irreversible blindness. Minimally invasive surgical techniques, such as ab interno trabecular bypass surgery, have been introduced to prevent glaucoma progressing. OBJECTIVES: The main objective was to assess the results at two years of ab interno trabecular bypass surgery with Trabectome for open angle glaucoma in comparison to conventional medical, laser, or surgical treatment in terms of efficacy and safety. A secondary objective was to examine the effects of Trabectome surgery in people who have concomitant phacoemulsification in comparison to those who do not have concomitant phacoemulsification...
August 15, 2016: Cochrane Database of Systematic Reviews
Victoria Vickerstaff, Gareth Ambler, Catey Bunce, Wen Xing, Gus Gazzard
BACKGROUND: The LiGHT trial (Laser-1st versus Drops-1st for Glaucoma and Ocular Hypertension Trial) is a multicentre randomised controlled trial of two treatment pathways for patients who are newly diagnosed with open-angle glaucoma (OAG) and ocular hypertension (OHT). The main hypothesis for the trial is that lowering intraocular pressure (IOP) with selective laser trabeculoplasty (SLT) as the primary treatment ('Laser-1st') leads to a better health-related quality of life than for those started on IOP-lowering drops as their primary treatment ('Medicine-1st') and that this is associated with reduced costs and improved tolerability of treatment...
November 11, 2015: Trials
R M H Lee, J D Oleszczuk, J N Hyer, G Gazzard
No abstract text is available yet for this article.
April 2014: Eye
Rahat Husain, Wen Li, Gus Gazzard, Paul J Foster, Paul T Chew, Francis T Oen, Rachel Phillips, Peng T Khaw, Steve K Seah, Tin Aung
BACKGROUND/AIMS: To investigate longitudinal changes in anterior chamber depth (ACD) and axial length (AXL) over 5 years after trabeculectomy surgery in Asian patients with primary glaucoma, and to identify factors associated with these changes. METHODS: In this prospective cohort study, phakic subjects with primary glaucoma who underwent trabeculectomy had ACD and AXL measured over 5 years. The effect of intraocular pressure (IOP) on ACD and AXL was determined...
July 2013: British Journal of Ophthalmology
Cheryl S F Ngo, Maria Cecilia Aquino, Shabana Noor, Seng Chee Loon, Chelvin C A Sng, Gus Gazzard, Wan-ling Wong, Paul T K Chew
INTRODUCTION: To describe the optic disc, visual field and ocular characteristics of a consecutive cohort of Asian patients with chronic primary angle-closure glaucoma (CPACG), and compare them with those having primary open-angle glaucoma (POAG). METHODS: In a prospective comparative case series of new patients with POAG or CPACG in Singapore, all patients underwent visual acuity assessment, slit-lamp examination, tonometry, gonioscopy, refraction, Heidelberg Retina Tomograph (HRT) and Humphrey visual field (HVF) assessment...
March 2013: Singapore Medical Journal
Melissa H Y Wong, Rahat Husain, Bryan C H Ang, Gus Gazzard, Paul J Foster, Hla M Htoon, Tina T Wong, Francis T Oen, Peng T Khaw, Steve K Seah, Tin Aung
OBJECTIVE: To report the 8-year outcomes of Asian subjects who underwent trabeculectomy augmented by intraoperative 5-fluorouracil (5-FU) or placebo. DESIGN: Retrospective review of a randomized controlled trial. PARTICIPANTS: Subjects with primary open-angle or angle-closure glaucoma. METHODS: Study subjects were prospectively followed up for 3 years. After the last subject recruited had completed 8 years of follow-up, the charts of all subjects were reviewed to capture data from the year 3 visit onward...
June 2013: Ophthalmology
Rahat Husain, Gus Gazzard, Tin Aung, Yuming Chen, Vishwanath Padmanabhan, Francis T S Oen, Steve K L Seah, Sek-Tien Hoh
PURPOSE: To compare the 2-year efficacy of phacoemulsification and intraocular lens implant (phaco/IOL) with laser peripheral iridotomy (LPI) in the early management of acute primary angle closure (APAC) and coexisting cataract. DESIGN: Randomized, controlled trial. PARTICIPANTS: We included 37 subjects presenting with APAC who had responded to medical treatment such that intraocular pressure (IOP) was ≤30 mmHg within 24 hours, and had cataract with visual acuity of ≤6/15...
November 2012: Ophthalmology
Alexander C Day, Gianluca Baio, Gus Gazzard, Catey Bunce, Augusto Azuara-Blanco, Beatriz Munoz, David S Friedman, Paul J Foster
AIM: To estimate the prevalence of primary angle closure glaucoma (PACG) in European derived populations. METHOD: Systematic review and modelling of PACG prevalence data from population studies. PACG was defined according to the ISGEO definition requiring structural and/or functional evidence of glaucomatous optic neuropathy. Prevalence estimates were applied to the 2010 United Nations projected population figures to estimate case numbers. RESULTS: The prevalence of PACG in those 40 years or more is 0...
September 2012: British Journal of Ophthalmology
Rahat Husain, Shen Liang, Paul J Foster, Gus Gazzard, Catey Bunce, Paul T K Chew, Francis T S Oen, Peng T Khaw, Steve K L Seah, Tin Aung
OBJECTIVE: To determine whether the timing of cataract surgery after trabeculectomy has an effect on trabeculectomy function in terms of intraocular pressure control. METHODS: This was a cohort study nested within a randomized clinical trial. There were 235 participants with glaucoma who had a single previous trabeculectomy augmented with either intraoperative 5-fluorouracil or placebo. Cataract surgery with intraocular lens implantation was performed on participants judged to have significant lens opacity...
February 2012: Archives of Ophthalmology
Alexander C Day, David Machin, Tin Aung, Gus Gazzard, Rahat Husain, Paul T K Chew, Peng T Khaw, Steve K L Seah, Paul J Foster
PURPOSE: To examine the association between central corneal thickness (CCT) and glaucoma. METHODS: This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore. RESULTS: Mean CCT in 938 community subjects was 539 μm ± 32 μm, and in 12 community subjects with primary open angle glaucoma (POAG) the mean CCT was 545 μm ± 38 μm...
October 2011: Investigative Ophthalmology & Visual Science
D Julian de Silva, Alexander C Day, Catey Bunce, Gus Gazzard, Paul J Foster
AIMS: To compare iridotomy outcomes in dark irides by 1064 nm pulsed Nd:YAG laser with and without 532 nm continuous-wave Nd:YAG (frequency-doubled) green laser pretreatment. METHODS: 30 patients with occludable anterior chamber angles underwent bilateral standard pulsed 1064 nm Nd:YAG laser iridotomy with one eye randomly assigned to sequential pretreatment with 532 nm continuous-wave Nd:YAG laser. Outcome measures were iridotomy patency and complications including haemorrhage and elevated intraocular pressure (IOP)...
February 2012: British Journal of Ophthalmology
Seng Chee Loon, Louis Tong, Gus Gazzard, Yiong Huak Chan, Ee Ling Sim, Tin Aung, Donald T H Tan, P R Healey, Tien Yin Wong, Victor Koh, Seang Mei Saw
PURPOSE: To evaluate the measurement of optic disc morphology using Heidelberg Retinal Tomography (HRT) with and without the aid of optic disc photos. METHODS: One hundred three children (aged 11 and 12 y, 52 boys) were selected randomly from the Singapore Cohort study of Risk Factors for Myopia. Optic nerve head topography and retinal nerve fiber layer thickness measurements were assessed using the HRT-II (Heidelberg, Germany) scanning laser ophthalmoscope. All contour lines were drawn by the same researcher on 2 occasions...
April 2011: Journal of Glaucoma
Tina T Wong, Peng T Khaw, Tin Aung, Paul J Foster, Hla Myint Htoon, Francis T S Oen, Gus Gazzard, Rahat Husain, Joe G Devereux, Darwin Minassian, Say-Beng Tan, Paul T K Chew, Steve K L Seah
PURPOSE: To report 3-year results of a randomized, controlled trial comparing the use of a single application of 5-fluorouracil (5-FU) with placebo in trabeculectomy surgery. DESIGN: Prospective, randomized, double-blinded treatment trial. PARTICIPANTS: Two hundred forty-three Asian patients with primary open-angle or primary angle-closure glaucoma undergoing primary trabeculectomy. METHODS: One eye of each patient was randomized to receive either intraoperative 5-FU or normal saline (placebo) during trabeculectomy...
February 2009: Ophthalmology
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