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https://www.readbyqxmd.com/read/29802818/a-randomized-controlled-phase-i-ii-study-to-evaluate-the-safety-and-efficacy-of-mgv354-for-ocular-hypertension-or-glaucoma
#1
Rebecca Stacy, Kenneth Huttner, Jen Watts, James Peace, David Wirta, Tom Walters, Kenneth Sall, John Seaman, Xiao Ni, Ganesh Prasanna, Muneto Mogi, Christopher Adams, Jing-He Yan, Michael Wald, Yunsheng He, Ronald Newton, Randall Kolega, Cynthia Grosskreutz
PURPOSE: To assess the clinical safety, tolerability, and efficacy of topically administered MGV354, a soluble guanylate cyclase (sGC) activator, in patients with ocular hypertension (OH) or glaucoma DESIGN: Double-masked, randomized, and vehicle-controlled study METHODS: Parts 1 and 2 evaluated safety and tolerability to identify the maximum tolerated dose (MTD) of once daily MGV354 in 32 healthy volunteers (Part 1) and 16 patients with OH or glaucoma (Part 2) at a single clinical site...
May 23, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29780928/spontaneous-regression-of-epithelial-downgrowth-from-clear-corneal-phacoemulsification-wound
#2
Ryan M Jaber, Mark Harrod, Jeffrey M Goshe
Purpose: To report a case of spontaneous regression of optical coherence tomography (OCT) and confocal microscopy-supported epithelial downgrowth associated with clear corneal phacoemulsification wound. Observations: A 66-year-old Caucasian male presented two years after phacoemulsification in the left eye with an enlarging cornea endothelial lesion in that eye. His early post-operative course had been complicated by corneal edema and iris transillumination defects...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780917/advanced-pigment-dispersion-glaucoma-secondary-to-phakic-intraocular-collamer-lens-implant
#3
Clara Ye, Cajal K Patel, Anna C Momont, Yao Liu
Purpose: We report a case of pigment dispersion glaucoma secondary to uncomplicated phakic intraocular collamer lens (ICL) (Visian ICL™, Staar Inc., Monrovia, CA) implant that resulted in advanced visual field loss. Observations: A 50-year-old man presented for routine follow-up status post bilateral phakic intraocular collamer lens (ICL) placement 8 years earlier. He was incidentally found to have a decline in visual acuity from an anterior subcapsular cataract and elevated intraocular pressure (IOP) in the left eye...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29777045/ten-year-incidence-of-primary-angle-closure-in-elderly-chinese-the-liwan-eye-study
#4
Lanhua Wang, Wenyong Huang, Shengsong Huang, Jian Zhang, Xinxing Guo, David S Friedman, Paul J Foster, Mingguang He
PURPOSE: To determine the 10-year incidence of all forms of primary angle closure (PAC) in phakic eyes and its risk factors in an urban Chinese population aged 50 years and older. METHODS: Survivors of 1405 baseline participants were invited to attend the 10-year follow-up visit in the Liwan Eye Study. Participants with established baseline angle closure, including primary angle closure suspects (PACS), PAC and primary angle closure glaucoma (PACG), or those who underwent bilateral cataract surgery during the 10-year period, as well as those who did not tolerate gonioscopic examinations, were excluded from this analysis...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29769188/sturge-weber-syndrome-associated-glaucoma-and-intraocular-osseous-metaplasia-a-unique-complicated-case
#5
Dmytro Pavlenko, Tetiana Scovpen, Oksana Vitovska
A 30-year-old European man was admitted to our centre complaining about severe pain of the right eye (OD) and right part of the face, redness and no vision of the OD. He had an 18-year history of secondary to Sturge-Weber syndrome glaucoma, 6-month history of red eye and 1-week history of pain in OD. The best-corrected visual acuity was no light perception OD and 20/20 OS. Intraocular pressure was 36 mm Hg OD. Examination revealed endophthalmitis, Sturge-Weber syndrome-associated glaucoma and complicated cataract of OD...
May 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29751260/forkhead-box-c1-gene-variant-causing-glaucoma-and-small-vessel-angiopathy-can-mimic-multiple-sclerosis
#6
Jagannadha R Avasarala, Julie R Jones, Curtis R Rogers
A 34-year old Caucasian female was initially diagnosed with multiple small-vessel strokes at age 20 years which were etiologically classified as secondary to anti-phospholipid antibody syndrome (APS) although she had no history or laboratory data to suggest APS. Based on her MRI of brain findings, one of her neurologists was concerned she could have multiple sclerosis (MS) and hence the patient was referred to our clinic for further evaluation. The patient's MRI of brain showed confluent lesions in the periventricular and juxta-cortical lesions that fulfil 2017 McDonald criteria for dissemination in space...
April 21, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29741535/amanita-muscaria-fly-agaric-from-a-shamanistic-hallucinogen-to-the-search-for-acetylcholine
#7
M R Lee, E Dukan, I Milne
The mushroom Amanita muscaria (fly agaric) is widely distributed throughout continental Europe and the UK. Its common name suggests that it had been used to kill flies, until superseded by arsenic. The bioactive compounds occurring in the mushroom remained a mystery for long periods of time, but eventually four hallucinogens were isolated from the fungus: muscarine, muscimol, muscazone and ibotenic acid. The shamans of Eastern Siberia used the mushroom as an inebriant and a hallucinogen. In 1912, Henry Dale suggested that muscarine (or a closely related substance) was the transmitter at the parasympathetic nerve endings, where it would produce lacrimation, salivation, sweating, bronchoconstriction and increased intestinal motility...
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29739991/systemic-hypertension-is-not-protective-against-chronic-intraocular-pressure-elevation-in-a-rodent-model
#8
Anna K van Koeverden, Zheng He, Christine T O Nguyen, Algis J Vingrys, Bang V Bui
High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure - intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703882/unusual-association-of-aniridia-with-aicardi-gouti%C3%A3-res-syndrome-related-congenital-glaucoma-in-a-tertiary-care-center
#9
Hebah M Musalem, Qais S Dirar, Selwa A F Al-Hazzaa, Abdul-Aziz A Al Zoba, Jeylan El-Mansoury
BACKGROUND Aicardi-Goutières syndrome (AGS) is a rare autosomal recessive encephalopathy of early onset. AGS visual dysfunction range from nystagmus and optic atrophy to cortical blindness in affected individuals; however, congenital glaucoma has been recently noticed among AGS pediatric patients. According to the literature, aniridia has never been recognized among AGS patients. CASE REPORT We report the case of a 4-year-old boy with AGS who had multiple congenital anomalies in the eyes. He was found to have congenital glaucoma, nystagmus, spherophakia with shallow chambers, and aniridia in both eyes...
April 28, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29674168/spikes-might-precede-seizures-and-predict-epilepsy-in-children-with-sturge-weber-syndrome-a-pilot-study
#10
Claire Bar, Anna Kaminska, Rima Nabbout
PURPOSE: Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by a facial port-wine stain, a glaucoma, and a leptomeningeal angioma. Epilepsy occurs in more than 75% of affected children, and seizures occurring in the first year of life are associated with a poor neurological prognosis. The aim of this study was to identify possible predictive markers of epilepsy on electroencephalogram (EEG) performed prior to seizure onset in children with SWS. METHODS: This study included children with a diagnosis of SWS who had an EEG performed prior to seizure onset...
July 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29613981/phacomorphic-angle-closure-following-silicone-oil-tamponade-in-a-pediatric-patient
#11
Victoria C Leung, Simon S M Fung, Rajeev Muni, Asim Ali
PURPOSE: The purpose of this study was to report a case of phacomorphic glaucoma following retinal detachment repair with silicone oil (SO) in a pediatric patient. STUDY DESIGN: Case report. METHODS: A chart review was conducted at St. Michael's Hospital and The Hospital for Sick Children (Toronto, Canada), where the patient received ophthalmic care from July 28, 2015 onwards. RESULTS: A 14-year-old boy with a history of traumatic retinal detachment and proliferative vitreoretinopathy in the left eye, requiring 2 pars plana vitrectomies, membrane peel, and SO tamponade, presented with 1-day history of decreased vision in the left eye, severe headache, nausea, and vomiting...
June 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29595636/evidence-based-practice-guideline-of-chinese-herbal-medicine-for-primary-open-angle-glaucoma-qingfeng-neizhang
#12
REVIEW
Yingxin Yang, Qiu-Yan Ma, Yue Yang, Yu-Peng He, Chao-Ting Ma, Qiang Li, Ming Jin, Wei Chen
BACKGROUND: Primary open angle glaucoma (POAG) is a chronic, progressive optic neuropathy. The aim was to develop an evidence-based clinical practice guideline of Chinese herbal medicine (CHM) for POAG with focus on Chinese medicine pattern differentiation and treatment as well as approved herbal proprietary medicine. METHODS: The guideline development group involved in various pieces of expertise in contents and methods. Authors searched electronic databases include CNKI, VIP, Sino-Med, Wanfang data, PubMed, the Cochrane Library, EMBASE, as well as checked China State Food and Drug Administration (SFDA) from the inception of these databases to June 30, 2015...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29569087/reversal-of-retinal-pigment-epithelial-detachment-after-cessation-of-topical-travoprost-therapy
#13
Venkataramana Kalikivayi, Jerry Joseph, Blessy Thankom Mathews, Rajkumar Maheswari, Satyajit Mulanjur Vadakara, Sajeev Cherian Jacob
PURPOSE: To report the rare incidence of retinal pigment epithelial detachment (RPED) followed by topical travoprost therapy and its subsequent reattachment after cessation of the drug. METHODS: A 60-year-old male presented with gradual loss of vision in both eyes and distorted images in right eye. He gave a history of visiting an ophthalmologist a week ago for a routine eye examination. His previous reports revealed best-corrected visual acuity (BCVA) of 6/6, N6 in both eyes with raised intraocular pressures...
March 22, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29564804/management-of-complications-of-cosmetic-iris-implants-in-a-phakic-eye-a-case-report-and-literature-review
#14
Millicent Bore, Nikhil Choudhari, Sunita Chaurasia
PURPOSE: To report the intricacies of managing complications that arose out of cosmetic iris implants (BrightOcular) placement. DESIGN: Interventional case report. METHODS: A thirty-year-old gentleman presented with complaint of progressive loss of vision after having cosmetic iris implant surgery to change his eye colour. He then developed raised intraocular pressures and had a right eye trabeculectomy conducted with the implants in situ...
March 21, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29561500/optic-disc-features-in-highly-myopic-eyes-the-zoc-bhvi-high-myopia-cohort-study
#15
Zhixi Li, Xinxing Guo, Ou Xiao, Pei Ying Lee, Ran Liu, Decai Wang, Padmaja Sankaridurg, Mingguang He
SIGNIFICANCE: Some studies reported that optic disc tilt and rotation might be risk factors for the susceptibility of high myopic eyes to develop glaucoma. However, data regarding optic disc manifestations in high myopia participants are few. It is crucial to characterize the features of optic disc manifestations among high myopes. PURPOSE: To describe optic disc characteristics of Chinese highly myopic eyes and to investigate associated factors. METHODS: This cross-sectional, observational study included 890 Chinese with bilateral high myopia (defined as ≤-6...
April 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29550190/six-month-longitudinal-comparison-of-a-portable-tablet-perimeter-with-the-humphrey-field-analyzer
#16
Selwyn Marc Prea, Yu Xiang George Kong, Aditi Mehta, Mingguang He, Jonathan G Crowston, Vinay Gupta, Keith R Martin, Algis J Vingrys
PURPOSE: To establish the medium-term repeatability of the iPad perimetry app Melbourne Rapid Fields (MRF) compared to Humphrey Field Analyzer (HFA) 24-2 SITA-standard and SITA-fast programs. DESIGN: Multicenter longitudinal observational clinical study. METHODS: Sixty patients (stable glaucoma/ocular hypertension/glaucoma suspects) were recruited into a 6-month longitudinal clinical study with visits planned at baseline and at 2, 4, and 6 months...
June 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29503962/intraocular-and-extraocular-hemorrhage-associated-with-ligature-release-of-non-valved-glaucoma-drainage-implant
#17
Michelle Go, J Niklas Ulrich, David Fleischman
Purpose: To report a rare complication of non-valved glaucoma drainage device surgery. Observations: An 85-year-old pseudophakic white male presented with painless vision loss and bloody tears. He was 5 weeks removed from uncomplicated non-valved glaucoma drainage device (Baerveldt 101-350, [AMO, Santa Clara, CA]). There was serosanguinous discharge without apparent source and a 25% layering hyphema in the anterior chamber. The tube was unobstructed in the anterior chamber and not abutting the iris...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29503950/surgical-interventions-for-late-ocular-complications-of-relapsing-polychondritis
#18
Yuan He, Huifeng Liu, Zhi Ji, Binliang Zhu
Purpose: To report a case of surgical interventions for a patient with relapsing polychondritis who presented with late ocular complications. Observations: A 44-year-old male was diagnosed to have relapsing polychondritis on the basis of recurrent acute auricular chondritis, deformity of the ear, saddle nose deformity and painful nasal chondritis, acute ocular inflammation with conjunctivitis, episcleritis and keratouveitis, laryngotracheal chondritis, erythema nodosum in the skin, a history of polyarthritis, and abnormal blood examination findings...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29501771/grgm-13-comprising-13-plant-and-animal-products-inhibited-oxidative-stress-induced-apoptosis-in-retinal-ganglion-cells-by-inhibiting-p2rx7-p38-mapk-signaling-pathway
#19
Qiu-Li Zhang, Wei Wang, Yan Jiang, A-Tuya, Dongmei, Lan-Lan Li, Zhan-Jun Lu, He Chang, Tian-Zi Zhang
OBJECTIVE: To determine the effectiveness of GRGM-13 on oxidative stress induced apoptosis of retinal ganglion cells (RGCs) and revealed its possible mechanism. MATERIALS AND METHODS: Caspase-3 activity, MDA level, and glutathione peroxidase level were detected by Caspase-3 assay kit, Lipid Peroxidation MDA Assay Kit, and Total Glutathione Peroxidase Assay Kit, respectively. Protein levels of Bax, Bcl-2, p-p38 and p38 were observed by Western Blot. Reactive oxygen species assay kit was used to determine intracellular ROS level...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29485475/extensive-submacular-hemorrhage-after-trabeculectomy-with-mitomycin-c
#20
Gyu-Nam Kim, Min-Ho Shin, Ja-Young Ahn, Yong-Seop Han, In-Young Chung, Seong-Wook Seo, Jong-Moon Park, Ji-Myong Yoo, Seong-Jae Kim
PURPOSE: We report the occurrence of an extensive submacular hemorrhage after trabeculectomy with mitomycin C in a patient with an occult choroidal neovascular membrane (CNVM). PATIENTS AND METHODS: A 66-year-old man had a 3-year history of primary open-angle glaucoma in the left eye, which had been treated with topical antiglaucoma medication. The patient had age-related macular degeneration with an occult CNVM, for which he had received 5 intravitreal injections of ranibizumab and 5 intravitreal injections of bevacizumab in the left eye over a 3-year period...
May 2018: Journal of Glaucoma
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