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https://www.readbyqxmd.com/read/27877085/the-evolving-functions-of-autophagy-in-ocular-health-a-double-edged-sword
#1
REVIEW
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis. Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27847689/a-comparison-of-perimetric-results-from-a-tablet-perimeter-and-humphrey-field-analyzer-in-glaucoma-patients
#2
Yu Xiang George Kong, Mingguang He, Jonathan G Crowston, Algis J Vingrys
PURPOSE: To determine the correlation between the perimetric outcomes from perimetry software Melbourne Rapid Fields (MRF) run on an Apple iPad tablet and those from the Humphrey Field Analyzer (HFA). METHODS: The MRF software was designed with features including variable fixation and fast thresholding using Bayes logic. Here, we report a cross-sectional study on 90 eyes from 90 participants: 12 had normal optic nerves and 78 had glaucoma with various degrees of visual field loss (41 mild and 37 moderate-severe)...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27800267/herpetic-keratouveitis-and-trabeculectomy-failure-during-infliximab-therapy-in-a-patient-with-beh%C3%A3-et-s-disease
#3
Sirel Gür Güngör, Leyla Asena, Ahmet Akman, Onur Gökmen
A 51-year-old man was diagnosed with Behçet's disease in 2001. The patient was resistant to all immunosuppressive therapies. After 6 months of infliximab therapy, he presented to our clinic with pain and blurred vision in his right eye. The visual acuity was 20/200 and the intraocular pressure was 35 mmHg in the right eye. Biomicroscopic examination revealed corneal dendritic ulcers and 2+ cells in the anterior chamber in the right eye. The herpetic keratouveitis attack was controlled with antiviral therapy but the patient needed another glaucoma surgery...
April 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27752377/a-rare-case-of-amyloidosis-of-the-eyelid-and-conjunctiva
#4
Zaria Ali, Bertie Fernando
Amyloidosis of the eyelid is uncommon and is typically associated with systemic associations. In contrast, amyloidosis of the conjunctiva is often localised with no other associations. We present a rare case of a 92-year-old gentleman with both cutaneous lid lesions and conjunctival amyloid with no systemic involvement. Biopsy demonstrated the hallmarks of amyloid and treatment has remained conservative. He remains at the department to be monitored for secondary glaucoma.
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27726460/boston-type-i-keratoprosthesis-implantation-following-autologous-submandibular-gland-transplantation-for-end-stage-ocular-surface-disorders
#5
Jianjun Gu, Jiajie Zhai, Guiqing Liao, Jiaqi Chen
PURPOSE: To describe the results of Boston keratoprosthesis implantation in a patient with Stevens-Johnson syndrome following autologous submandibular gland transplantation. DESIGN: Observational case report. METHODS: We report the case of a man diagnosed with Stevens-Johnson syndrome. Autologous submandibular gland transplantation was performed in the right eye in 2008 to ameliorate tear film deficiency. Due to the improvement in the microenvironment of the ocular surface, Boston keratoprosthesis implantation was performed in the right eye in 2011...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27711151/intraocular-pressure-induced-retinal-changes-identified-using-synchrotron-infrared-microscopy
#6
Hsin-Hui Shen, Guei-Sheung Liu, Seong Hoong Chow, Jiang-Hui Wang, Zheng He, Christine Nguyen, Tsung-Wu Lin, Bang V Bui
Infrared (IR) spectroscopy has been used to quantify chemical and structural characteristics of a wide range of materials including biological tissues. In this study, we examined spatial changes in the chemical characteristics of rat retina in response to intraocular pressure (IOP) elevation using synchrotron infrared microscopy (SIRM), a non-destructive imaging approach. IOP elevation was induced by placing a suture around the eye of anaesthetised rats. Retinal sections were collected onto transparent CaF2 slides 10 days following IOP elevation...
2016: PloS One
https://www.readbyqxmd.com/read/27704408/altered-functional-connectivity-within-and-between-the-default-model-network-and-the-visual-network-in-primary-open-angle-glaucoma-a-resting-state-fmri-study
#7
Jieqiong Wang, Ting Li, Peng Zhou, Ningli Wang, Junfang Xian, Huiguang He
To explore the alterations of functional connectivity (FC) and connections within and between the subnetworks of the visual network and the default mode network in glaucoma. We applied the independent component analysis to obtain two resting-state networks (RSNs), which were the visual network and the default mode network (DMN), from the resting-state fMRI data of 25 primary open-angle glaucoma (POAG) patients and 25 well-matched normal controls. Then FC analysis was performed to obtain the altered FC within the RSNs, whereas the functional network connectivity (FNC) analysis was performed within and between these two RSNs...
October 4, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27617027/chi-ju-di-huang-wan-protects-rats-against-retinal-ischemia-by-downregulating-matrix-metalloproteinase-9-and-inhibiting-p38-mitogen-activated-protein-kinase
#8
Hsiao-Ming Chao, Lei Hu, Ji-Min Cheng, Xiao-Qian Liu, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Xiu-Mei Zhang
BACKGROUND: Retinal ischemia is a retinal disorder related to retinal vascular occlusion, glaucoma, diabetic retinopathy and age-related macular degeneration. The study aimed to evaluate the protective effects and underlying mechanisms of Chi-Ju-Di-Huang-Wan (CJDHW) against retinal ischemia in rats. METHODS: High intraocular pressure (HIOP)-induced retinal ischemia was established in Wistar rats by raising their intraocular pressure to 120 mmHg for 60 min with in an eye whose anterior chamber was cannulated with a 30-guage needle adapted to a normal saline bottle through an intravenous line...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27586212/electroconvulsive-therapy-in-a-patient-with-glaucoma
#9
Ameya Amritwar, Sagar Karia, Avinash De Sousa, Sushma Sonavane
There is little information on the use of electroconvulsive therapy (ECT) in the presence of glaucoma. An elderly man with known severe depression underwent surgery for cataract and glaucoma in the left eye. His depression worsened in the postoperative period and he required two sessions of ECT within 2 months of the surgery. There were no ophthalmic complications or adverse events associated with ECT and he responded well to treatment.
March 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/27521670/intraoperative-floppy-iris-syndrome-associated-with-use-of-antipsychotic-drugs
#10
Masato Matsuo, Ichiya Sano, Yoshifumi Ikeda, Etsuko Fujihara, Masaki Tanito
OBJECTIVE: We report 3 cases of intraoperative floppy-iris syndrome (IFIS) during cataract surgery in patients without a history of selective α1-blocker use but with a long-term history of antipsychotic drug use. We reviewed previously reported cases of antipsychotic drug-associated IFIS cases. DESIGN: Observational case series. RESULTS: In case 1, bilateral IFIS developed in a 39-year-old man with chronic angle-closure glaucoma. He had used several classes of antipsychotic drugs to treat schizophrenia, including the first-generation antipsychotic drugs haloperidol and chlorpromazine, the dopamine system stabilizer aripiprazole, the dopamine serotonin antagonists olanzapine and quetiapine, and the serotonin dopamine antagonists risperidone and blonanserin for 7 years...
August 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27508422/large-retinal-pigment-epithelial-rip-associated-with-bullous-retinal-and-choroidal-detachment
#11
Jesse T McCann, Michael Engelbert
PURPOSE: To report a giant retinal pigment epithelium rip in a patient with a bullous retinal and choroidal detachment. METHODS: Case report with widefield imaging, fundus autofluorescence, and optical coherence tomography of the retina. RESULTS: This 62-year-old patient had a history of advanced glaucoma, trabeculectomy, blebitis, and endophthalmitis. He had cataract surgery 6 weeks before presentation. He was found to have a large bullous retinal and choroidal detachment with a large retinal pigment epithelium tear at the limit of the choroidal detachment...
August 9, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27432524/conversion-of-primary-to-phacomorphic-angle-closure-glaucoma-case-report
#12
Christine To Nguyen, Zheng He, Kangyi Luo
No abstract text is available yet for this article.
July 19, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27428613/matrix-metalloproteinase-1-rs1799750-polymorphism-and-glaucoma-a-meta-analysis
#13
Miao He, Wei Wang, Xiao Han, Wenyong Huang
PURPOSE: Several studies indicated that -1607 1G/2G (rs1799750) polymorphism in matrix metalloproteinase-1 (MMP-1) promoter was correlated with glaucoma susceptibility, but the results remain controversial. We performed a meta-analysis to assess whether rs1799750 confers glaucoma risk. METHODS: Eligible studies were retrieved by systematically searching Pubmed, Embase, Web of Science, and Chinese Biomedical database. The degree of correlation was expressed as odds ratios (ORs) and 95% confidence interval (CI)...
July 18, 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27398604/long-term-complications-of-posterior-chamber-phakic-refractive-lenses-case-report-and-literature-review
#14
X-P Chen, F Yuan, Y-Z Yuan, Q-L He
Aim: This article presents two cases of phakic refractive lens (PRL) complications in China. Methods: Case 1 presents a highly myopic patient with PRL's footplate partly subluxated into the anterior chamber by blunt trauma one year after implantation. The PRL was repositioned successfully without other complications. Case 2 represents a case of pigment dispersion glaucoma developed seven years after PRL implantation. Intraocular pressure (IOP) lowering therapy was initiated and the IOP continued to be in the normal range for both affected eyes with ongoing follow-up...
December 10, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27349783/elizabethkingia-meningoseptica-and-contact-lens-use
#15
Joao N Beato, Maria J Espinar, Luís Figueira, Yuliana O Eremina, Manuela Ribeiro, Raúl Moreira, Fernando Falcão-Reis
A 47-year-old man presented to our emergency department complaining of acute ocular pain and redness of his left eye. Ophthalmological antecedents included use of semi-rigid contact lens and primary open-angle glaucoma. Slit-lamp examination revealed a small central corneal ulcer associated with stromal inflammatory infiltrate. Scraping from the corneal ulcer was positive for Elizabethkingia meningoseptica. He was empirically treated with topical 0.5% levofloxacin and 0.3% gentamicin, and five weeks later the infection had resolved...
April 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27275656/juvenile-onset-normal-tension-glaucoma-from-chronic-recurrent-low-cerebrospinal-fluid-pressure
#16
Imran H Yusuf, Gokularaj Ratnarajan, Richard S Kerr, John F Salmon
INTRODUCTION: The evidence for low cerebrospinal fluid pressure (CSFP) as a key parameter in the pathogenesis of glaucoma is increasing. Primate models have demonstrated the onset normal tension glaucoma (NTG) from experimentally induced chronic intrathecal hypotension; an approach not possible in human subjects. CASE PRESENTATION: A 27-year-old man presented with a central scotoma in his left eye. He had undergone 8 CSF shunt revision procedures over a 25-year period secondary to recurrent low CSFP following surgical excision of a pinealoblastoma, aged 2...
August 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27253617/automated-screening-system-for-retinal-health-using-bi-dimensional-empirical-mode-decomposition-and-integrated-index
#17
U Rajendra Acharya, Muthu Rama Krishnan Mookiah, Joel E W Koh, Jen Hong Tan, Sulatha V Bhandary, A Krishna Rao, Hamido Fujita, Yuki Hagiwara, Chua Kuang Chua, Augustinus Laude
Posterior Segment Eye Diseases (PSED) namely Diabetic Retinopathy (DR), glaucoma and Age-related Macular Degeneration (AMD) are the prime causes of vision loss globally. Vision loss can be prevented, if these diseases are detected at an early stage. Structural abnormalities such as changes in cup-to-disc ratio, Hard Exudates (HE), drusen, Microaneurysms (MA), Cotton Wool Spots (CWS), Haemorrhages (HA), Geographic Atrophy (GA) and Choroidal Neovascularization (CNV) in PSED can be identified by manual examination of fundus images by clinicians...
August 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27239454/orbital-extension-of-an-unsuspected-choroidal-melanoma-presumably-through-an-aqueous-tube-shunt
#18
Hayyam Kiratli, İrem Koç, Berçin Tarlan
AIMS: To report a patient with unrecognized small macular melanoma, who gradually developed neovascular glaucoma that was treated with an Ahmed valve. We presume that tumor cells gained access to the orbit through this aqueous drainage device. METHODS: The medical records pertaining to 5 different centers, the results of imaging studies, the clinical course of the patient and histopathological findings were retrospectively reviewed. RESULTS: A 61-year-old man presented with a blind and painful proptotic right eye...
April 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27229700/clinical-efficacy-of-modified-partial-pars-plana-vitrectomy-combined-with-phacoemulsification-for-malignant-glaucoma
#19
F He, Z Qian, L Lu, J Jiang, X Fan, Z Wang, X Xu
ObjectiveThe objective of this study was to evaluate the clinical effects of modified partial pars plana vitrectomy together with phacoemulsification, intraocular lens (IOL) implantation, posterior capsulectomy, and zonulohyaloidectomy for patients with malignant glaucoma after trabeculectomy or cataract surgery.DesignRetrospective, cohort study.ParticipantsThirty consecutive patients (30 eyes) with malignant glaucoma after trabeculectomy surgery or ultrasonic phacoemulsification of cataract between January 2008 and September 2014 were enrolled...
August 2016: Eye
https://www.readbyqxmd.com/read/27225273/iridoschisis-and-keratoconus-in-a-patient-with-severe-allergic-eye-disease-and-compulsive-eye-rubbing-a-case-report
#20
Imran H Yusuf, John F Salmon
BACKGROUND: Iridoschisis is a rare disorder characterized by splitting of the anterior and posterior iris stroma, resulting in disintegrated iris fibrils which float freely in the anterior chamber. We report an exceptional case of bilateral iridoschisis occurring in conjunction with keratoconus and severe allergic eye disease. CASE PRESENTATION: A 24-year-old white man had had periocular contact dermatitis and allergic eye disease from the age of 3 years. He was allergic to grass, animal hair, and pollen and worked grooming horses...
2016: Journal of Medical Case Reports
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