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https://www.readbyqxmd.com/read/28549090/sigma-1-receptor-regulates-mitochondrial-function-in-glucose-and-oxygen-deprived-retinal-ganglion-cells
#1
Dorette Z Ellis, Linya Li, Yong Park, Shaoqing He, Brett Mueller, Thomas Yorio
Purpose: Understanding the role of mitochondria in retinal ganglion cells (RGCs) is relevant to human disease as studies have shown mitochondrial abnormalities in primary open-angle glaucoma patients. This study seeks to determine the effects of the sigma-1 receptor (σ-1r) and its agonists on mitochondrial function in oxygen- and glucose- deprived (OGD) purified neonatal RGCs. Methods: Retinal ganglion cells were isolated from rat pups and subjected to OGD in varying conditions in the presence or absence of σ-1r agonist and antagonist and following addition of an AAV2-σ-1r vector that was used to increase σ-1r expression...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28450688/a-case-of-55-year-old-man-with-first-ever-generalized-seizure-diagnosed-with-sturge-weber-syndrome-type-iii-by-characteristic-mri-findings
#2
Hidehiro Ishikawa, Yuichiro Ii, Atsushi Niwa, Keita Matsuura, Masayuki Maeda, Hidekazu Tomimoto
A 55-year-old man with no mental retardation had presented a history of frequent transient clumsiness of his right upper and lower extremities for about 20 years. He was admitted to a general hospital with weakness of right side of the body, and first-ever generalized seizure attack occurred the next day. Brain CT showed calcification in the left cerebral cortices. So he was referred to our hospital. On neurological examination, he had mild clumsiness of his right upper limb and right pyramidal tract sign. He had neither facial port-wine stain nor glaucoma...
April 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28440470/proliferation-and-differentiation-of-direct-co%C3%A2-culture-of-bone-marrow-mesenchymal-stem-cells-and-pigmented-cells-from-the-ciliary-margin
#3
Yan Li, Xinzheng He, Jun Li, Fangfang Ni, Qingqing Sun, Yan Zhou
Damage of retinal ganglion cells (RGCs) is the major consequence of glaucoma and regeneration of RGCs is extremely difficult once the damage has occurred. Retinal stem cells (RSCs) are considered an ideal choice for RGC regeneration. Pigmented cells from the ciliary margin (PCMs) have great retinal differentiation potential and may be an ideal RSC candidate. However, the ciliary margin is too small, so the number of cells that can be obtained is limited. Bone marrow‑derived mesenchymal stem cells (BMMSCs) are another type of stem cell that have been previously investigated for RGC regeneration...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28424493/regulation-of-intraocular-pressure-by-microrna-cluster-mir-143-145
#4
Xinyu Li, Fangkun Zhao, Mei Xin, Guorong Li, Coralia Luna, Guigang Li, Qinbo Zhou, Yuguang He, Bo Yu, Eric Olson, Pedro Gonzalez, Shusheng Wang
Glaucoma is a major cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP), which causes optic nerve damage and retinal ganglion cell death, is the primary risk factor for blindness in glaucoma patients. IOP is controlled by the balance between aqueous humor secretion from the ciliary body (CB) and its drainage through the trabecular meshwork (TM). How microRNAs (miRs) regulate IOP and glaucoma in vivo is largely unknown. Here we show that miR-143 and miR-145 expression is enriched in the smooth muscle and trabecular meshwork in the eye...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416752/cdkn2b-gene-rs1063192-polymorphism-decreases-the-risk-of-glaucoma
#5
Zhenxian Hu, Chenliang He
The aim of this meta-analysis was to evaluate the association between cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene rs1063192 polymorphism and glaucoma risk. We searched the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 14 case-control studies involving 11,316 cases and 24,055 controls were included. Meta-analysis showed that CDKN2B gene rs1063192 polymorphism was associated with a decreased risk of glaucoma...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410254/decompression-retinopathy-after-goniotomy-in-a-child-a-case-report
#6
Eitan S Burstein, Peter A Netland
PURPOSE: To report a case of ocular decompression retinopathy that developed in a child after undergoing goniotomy for uncontrolled pediatric uveitic glaucoma. PATIENT AND METHODS: We describe an 11-year-old Hispanic boy with a history of idiopathic uveitis and elevated intraocular pressure (IOP) in both eyes. He developed marked elevation of the IOP in the right eye (44 mm Hg) despite glaucoma medical therapy. RESULTS: The patient's right eye was treated with goniotomy, with reduction of vision to 20/70 and IOP to between 4 and 7 mm Hg during the first week postoperatively...
April 13, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28302248/ocular-features-in-a-case-of-nevus-of-ota
#7
Murtaza Sameen Junejo, Muhammad Saim Khan, Ahsan Mukhtar
Oculodermal melanocytosis, also known as Nevus of Ota, is a hamartomatous melanocytic nevus of dermal melanocytes. It presents as a bluish grey patch on the face, which may be congenital or acquired involving the area of distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The nevus can be unilateral or bilateral, and, in addition to skin, it may involve ocular and oral mucosal surfaces. It is a rare disorder and the ocular complications, such as glaucoma and melanoma, may be vision or life-threatening...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28301497/long-term-outcomes-of-ciliary-sulcus-versus-capsular-bag-fixation-of-intraocular-lenses-in-children-an-ultrasound-biomicroscopy-study
#8
Yun-E Zhao, Xian-Hui Gong, Xue-Ning Zhu, He-Ming Li, Meng-Jun Tu, Terry G Coursey, Stephen C Pflugfelder, Feng Gu, Ding Chen
PURPOSE: To evaluate the long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses (IOLs) in children after pediatric cataract surgery. METHODS: IOL was implanted in the ciliary sulcus in 21 eyes of 14 children, and in the capsular bag in 19 eyes of 12 children for the treatment of pediatric cataract in an institutional setting. Ultrasound biomicroscopy (UBM) was performed. Main outcome measures included IOL decentration, IOL tilt, anterior chamber depth (ACD), angle-opening distance at 500 μm (AOD500), trabecular-iris angle (TIA), best-corrected visual acuity (BCVA), intraocular pressure (IOP), and incidence of postoperative complications...
2017: PloS One
https://www.readbyqxmd.com/read/28301490/a-novel-flexible-microfluidic-meshwork-to-reduce-fibrosis-in-glaucoma-surgery
#9
Behzad Amoozgar, Xiaoling Wei, Jun Hui Lee, Michele Bloomer, Zhengtuo Zhao, Paul Coh, Fei He, Lan Luan, Chong Xie, Ying Han
PURPOSE/RELEVANCE: Fibrosis and hence capsule formation around the glaucoma implants are the main reasons for glaucoma implant failure. To address these issues, we designed a microfluidic meshwork and tested its biocompatibility in a rabbit eye model. The amount of fibrosis elicited by the microfluidic meshwork was compared to the amount elicited by the plate of conventional glaucoma drainage device. METHODS: Six eyes from 3 New Zealand albino rabbits were randomized to receive either the novel microfluidic meshwork or a plate of Ahmed glaucoma valve model PF7 (AGV PF7)...
2017: PloS One
https://www.readbyqxmd.com/read/28300746/a-unique-case-of-keratoconus-with-cogan-reese-syndrome-and-secondary-glaucoma
#10
Lipi Chakrabarty
Keratoconus (KC), though one of the most common corneal degeneration, still continues to be a mystique regarding its pathogenesis, diagnosis, associations, and management; with newer discoveries and evolutions being reported. We report, what we believe to be another new association of KC- Cogan Reese syndrome with secondary glaucoma. A 32-year-old male, diagnosed as bilateral KC, presented for examination. Unilateral Cogan-Reese syndrome and associated secondary glaucoma was identified. These associations had been missed by previous ophthalmologists...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28288590/iridoschisis-a-case-report-and-literature-review
#11
Yiyi Chen, Yiyong Qian, Peirong Lu
BACKGROUND: Iridoschisis is a rare condition that is characterized by the separation of the iris stroma into layers, with portions of the anterior layer floating freely in the aqueous humour. Here, we report three cases of iridoschisis that were complicated by either a cataract or glaucoma. Based on these cases, we speculate that the scope of iridoschisis has a rare association with intraocular pressure and the loss of corneal endothelial cells after surgery, which is mainly due to the surgery and not iridocorneal mechanical contact...
March 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28269173/abnormal-interhemispheric-resting-state-functional-connectivity-in-primary-open-angle-glaucoma
#12
Peng Zhou, Jieqiong Wang, Ting Li, Ningli Wang, Junfang Xian, Huiguang He
Glaucoma is the second leading cause of blindness and it has been the topic of massive studies to explore the underlying mechanisms of the disease. Resting-state neuroimaging studies have been widely applied to investigate the functional damage of the brain, but little is known about the alterations of the interhemispheric resting-state functional connectivity (RSFC) in patients with primary open-angle glaucoma (POAG). In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to explore the interhemispheric RSFC of the brain in POAG patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260366/-application-value-of-corneal-hysteresis-in-diagnosis-and-treatment-of-glaucoma
#13
L Y He, L Liang, M N Zhu
Glaucoma is the first leading cause of irreversible blindness world widely, but the pathogenesis was still unclear. The collagen fibers from cornea and sclera connect to each other and both of them have similar extracellular matrix components. The biomechanical characteristics of optic nerve lamina cribrosa may associated with the biomechanical properties of the cornea. Therefore, the study of corneal physiological can indirectly reflex the compression and damage in optic nerve lamina cribrosa. The technical developments in corneal hysteresis examination had been updated these years constantly...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251080/clinical-results-of-non-descemet-stripping-endothelial-keratoplasty
#14
Tao Zhang, Shao-Wei Li, Tie-Hong Chen, Jing-Liang He, Yan-Wei Kang, Fang-Qi Lyu, Jian-Hua Ning, Chang Liu
AIM: To investigate the impact of non-Descemet stripping endothelial keratoplasty (non-DSEK) on graft rejection rate, and its overall procedural effectiveness in patients. METHODS: Non-DSEK was performed on 65 eyes of 64 patients, and the procedural outcomes, including rejection episodes, failure and dislocation of the grafts, best corrected visual acuity (BCVA), endothelial cell density (ECD), and other complications, were analyzed retrospectively. RESULTS: Of the 65 eyes, 63 recovered from bullous keratopathy with a clear cornea...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28249604/upregulation-of-the-endothelin-a-eta-receptor-and-its-association-with-neurodegeneration-in-a-rodent-model-of-glaucoma
#15
Nolan R McGrady, Alena Z Minton, Dorota L Stankowska, Shaoqing He, Hayden B Jefferies, Raghu R Krishnamoorthy
BACKGROUND: Primary open angle glaucoma is a heterogeneous group of optic neuropathies that results in optic nerve degeneration and a loss of retinal ganglion cells (RGCs) ultimately causing blindness if allowed to progress. Elevation of intraocular pressure (IOP) is the most attributable risk factor for developing glaucoma and lowering of IOP is currently the only available therapy. However, despite lowering IOP, neurodegenerative effects persist in some patients. Hence, it would be beneficial to develop approaches to promote neuroprotection of RGCs in addition to IOP lowering therapies...
March 1, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28248867/structural-and-functional-brain-changes-in-early-and-mid-stage-primary-open-angle-glaucoma-using-voxel-based-morphometry-and-functional-magnetic-resonance-imaging
#16
Ming-Ming Jiang, Qing Zhou, Xiao-Yong Liu, Chang-Zheng Shi, Jian Chen, Xiang-He Huang
To investigate structural and functional brain changes in patients with primary open-angle glaucoma (POAG) by using voxel-based morphometry based on diffeomorphic anatomical registration through exponentiated Lie algebra (VBM-DARTEL) and blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), respectively.Thirteen patients diagnosed with POAG and 13 age- and sex-matched healthy controls were enrolled in the study. For each participant, high-resolution structural brain imaging and blood flow imaging were acquired on a 3...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28227403/abnormal-interhemispheric-resting-state-functional-connectivity-in-primary-open-angle-glaucoma
#17
Peng Zhou, Jieqiong Wang, Ting Li, Ningli Wang, Junfang Xian, Huiguang He, Peng Zhou, Jieqiong Wang, Ting Li, Ningli Wang, Junfang Xian, Huiguang He, Ningli Wang, Junfang Xian, Huiguang He, Ting Li, Jieqiong Wang, Peng Zhou
Glaucoma is the second leading cause of blindness and it has been the topic of massive studies to explore the underlying mechanisms of the disease. Resting-state neuroimaging studies have been widely applied to investigate the functional damage of the brain, but little is known about the alterations of the interhemispheric resting-state functional connectivity (RSFC) in patients with primary open-angle glaucoma (POAG). In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to explore the interhemispheric RSFC of the brain in POAG patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220849/the-long-term-anterior-segment-configuration-after-pediatric-cataract-surgery-and-the-association-with-secondary-glaucoma
#18
Ding Chen, Xian-Hui Gong, He Xie, Xue-Ning Zhu, Jin Li, Yun-E Zhao
Secondary glaucoma constitutes major sight-threatening complication of pediatric cataract surgery, yet the etiology remains unclear. The purpose of this study was to investigate the long-term anterior segment configuration and the association with secondary glaucoma in pediatric pseudophakia. Ultrasound biomicroscopy (UBM) was performed on 40 eyes of 26 children underwent pediatric cataract surgery and intraocular lens (IOL) implantation. The anterior chamber depth (ACD), angle-opening distance at 500 μm (AOD500), trabecular-iris angle (TIA), central corneal thickness (CCT), structural abnormities, IOL position, IOP, and incidence of glaucoma were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219191/-study-of-optic-radiations-in-patients-with-primary-open-angle-glaucoma-with-diffusion-tensor-imaging
#19
T Li, W Miao, H G He, J F Xian
Objective: To study the alteration of the optic radiations in patients with primary open-angle glaucoma (POAG) by diffusion tensor imaging (DTI) and tractography, and to reveal the correlation between the DTI derived parameters and the severity of the disease. Methods: A total of 24 patients with POAG and 20 age- and gender-matched healthy controls were enrolled in this study from January 2011 to June 2013.All subjects underwent ophthalmoscopy, standard automatic perimetry, intraocular pressure measurement and MRI scanning...
February 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28203189/a-mystery-of-bilateral-annular-choroidal-and-exudative-retinal-detachment-with-no-systemic-involvement-is-it-part-of-vogt-koyanagi-harada-disease-spectrum-or-a-new-entity
#20
Ibrahim Elaraoud, Walter Andreatta, Li Jiang, Kenan Damer, Jalil Al-Ibrahim
A 65-year-old Caucasian male presented to the eye emergency department with bilateral significant visual loss. He was otherwise healthy with no significant past medical history. Ophthalmic history was significant for chronic open-angle glaucoma, for which the patient was using latanoprost once daily to both eyes. There was no preceding history of trauma or ocular surgery and the patient was emmetropic. Two weeks prior to his presentation, he reported a headache, which settled spontaneously. Slit-lamp examination demonstrated bilateral keratic precipitates, bilateral significantly shallow anterior chamber, and bilaterally normal intraocular pressures of 16 mm Hg...
January 2017: Case Reports in Ophthalmology
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