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https://www.readbyqxmd.com/read/29452841/impact-of-age-following-treatment-of-severely-calcified-coronary-lesions-with-the-orbital-atherectomy-system-3-year-follow-up
#1
Michael S Lee, Richard A Shlofmitz, Brad J Martinsen, Sanjum Sethi, Jeffrey W Chambers
OBJECTIVES: We investigated the safety and efficacy of coronary orbital atherectomy to treat severely calcified lesions prior to stenting based upon age. BACKGROUND: The ORBIT II study reported the safety and efficacy with orbital atherectomy in 443 patients with severely calcified lesions. Elderly patients undergoing percutaneous coronary intervention may be at increased risk for major adverse cardiac events (MACE) and death compared with younger patients. METHODS: Patients were stratified according to age (≥75 year old [174/443, 39...
January 31, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29450473/elevated-blood-viscosity-and-micro-recirculation-linked-to-coronary-stent-malapposition
#2
Eric Poon, Vikas Thondapu, Umair Hayat, Peter Barlis, Chooi Yap, Po Kuo, Qisen Wang, Jiawei Ma, Shuang Zhu, Stephen Moore, Andrew Ooi
One particular complexity of coronary artery is the natural tapering of the vessel with proximal segments having larger caliber and distal tapering as the vessel get smaller. The natural tapering of a coronary artery often leads to proximal incomplete stent apposition (ISA). ISA alters coronary hemodynamics and creates pathological path to develop complications such as in-stent restenosis, and more worryingly, stent thrombosis. By employing state-of-the-art computer-aided design software, generic stent hoops were virtually deployed in an idealized tapered coronary artery with decreasing malapposition distance...
February 14, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29448010/improved-outcomes-in-management-of-hypoplastic-left-heart-syndrome-associated-with-congenital-diaphragmatic-hernia-an-algorithmic-approach
#3
Kaitlin Balduf, T K Susheel Kumar, Umar Boston, Shyam Sathanandam, Marc V Lee, Tim Jancelewicz, Christopher J Knott-Craig
BACKGROUND: Hypoplastic left heart syndrome (HLHS) is the second most common congenital heart disease associated with congenital diaphragmatic hernia (CDH). The reported survival of neonates with CDH and HLHS is only 1-5%. We review our experience with CDH and HLHS and compare our outcomes to published literature. METHODS: Retrospective review of all neonates with CDH and HLHS at our institution over a 10 year period was performed. The morphology of cardiac and diaphragm defects, clinical course, treatment strategies and outcomes were reviewed and an algorithmic approach is proposed...
February 12, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29447780/nonprimary-pci-at-hospitals-without-cardiac-surgery-on-site-consistent-outcomes-for-all
#4
Matthew J Czarny, Julie M Miller, Daniel Q Naiman, Chao-Wei Hwang, Rani K Hasan, Cynthia C Lemmon, Thomas Aversano
BACKGROUND: The CPORT-E trial showed the noninferiority of nonprimary percutaneous coronary intervention (PCI) at hospitals without cardiac surgery on-site (SoS) compared with hospitals with SoS for 6-week mortality and 9-month major adverse cardiac events (MACE). However, target vessel revascularization (TVR) was increased at non-SoS hospitals. Therefore, we aimed to determine the consistency of the CPORT-E trial findings across the spectrum of enrolled patients. METHODS: Post hoc subgroup analyses of 6-week mortality and 9-month MACE, defined as the composite of death, Q-wave myocardial infarction, or TVR, were performed...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447002/recent-treatment-modalities-for-cardiovascular-diseases-with-a-focus-on-stem-cells-aptamers-exosomes-and-nanomedicine
#5
Rahul Mittal, Vasanti M Jhaveri, Hannah S McMurry, Sae-In Samantha Kay, Kyle J Sutherland, Lin Nicole, Jeenu Mittal, Rahul Dev Jayant
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Due to the significant impact of CVD on humans, there is a need to develop novel treatment modalities tailored to major classes of cardiac diseases including hypertension, coronary artery disease, cardiomyopathies, arrhythmias, valvular disease and inflammatory diseases. In this article, we discuss recent advancements regarding development of therapeutic strategies based on stem cells, aptamers, exosomes, drug-eluting and dissolvable stents, immunotherapy and nanomedicine for the treatment of CVD...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29443350/coronary-stent-restenosis-and-the-association-with-allergy-to-metal-content-of-316l-stainless-steel
#6
D Slodownik, C Danenberg, D Merkin, F Swaid, S Moshe, A Ingber, H Lotan, R Durst
BACKGROUND: Most intra-coronary stents in use are made of 316 L stainless steel, which contains nickel, chromate and molybdenum. Whether inflammatory and allergic reactions to metals contribute to in-stent restenosis is still a matter of debate. AIM: The aim of this study was to ascertain the relationship between metal allergy and the occurrence of in-stent restenosis. METHODS: Ninety-nine adult patients who underwent two cardiac catheterisations, up to two years apart, were included in the study...
January 24, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29437817/atherothrombotic-out-of-hospital-cardiac-arrest-watch-out-for-a-second-train
#7
Laura Petruescu, Fabien Picard, Alain Cariou, Olivier Varenne
A 63-year-old man presented with an out-of-hospital cardiac arrest. The coronary angiogram with intravascular imaging was performed and showed a mid-left anterior descending artery atherosclerotic cap rupture with thrombus burden treated with drug-eluting stent (DES) implantation. During the hospitalisation in the intensive care unit, the patient experienced recurrent ventricular fibrillations and asystole with transient ST-segment elevation in the inferior leads with normal coronary angiography. A methylergonovine provocative test was therefore performed and showed an occlusive right coronary artery (RCA) spasm...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29435272/optimal-antithrombotic-therapy-in-patients-with-atrial-fibrillation-following-percutaneous-coronary-intervention-a-systemic-review-and-meta-analysis
#8
Jing-Xiu Li, Yang Li, Shu-Jun Yan, Bai-He Han, Zhao-Yan Song, Wei Song, Shi-Hao Liu, Ji-Wei Guo, Shuo Yin, Ye-Ping Chen, De-Jun Xia, Xin Li, Xue-Qi Li, En-Ze Jin
A challenge for antithrombotic treatment is patients who present with atrial fibrillation (AF) and acute coronary syndrome, particularly in patients who have undergone coronary percutaneous intervention with stenting (PCIS). In the present study, a total of nine observational trials published prior to July 2017 that investigated the effects of dual antiplatelet therapy (DAPT; aspirin + clopidogrel) and triple oral antithrombotic therapy (TOAT; DAPT + warfarin) among patients with AF concurrent to PCIS were collected from the Medline, Cochrane and Embase databases and conference proceedings of cardiology, gastroenterology and neurology meetings...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29432400/treatment-of-coronary-artery-disease-with-a-new-generation-drug-coated-balloon-final-results-of-the-italian-elutax-sv-registry-dcb-rise
#9
Bernardo Cortese, Fabrizio D'Ascenzo, Raffaela Fetiveau, Vruyr Balian, Simonetta Blengino, Massimo Fineschi, Renata Rogacka, Corrado Lettieri, Andrea Pavei, Maurizio D'Amico, Arnaldo Poli, Gaetano Di Palma, Roberto A Latini, Pedro S Orrego, Romano Seregni
AIMS: Drug-coated balloons (DCBs) are a recognized alternative to stents for the treatment of in-stent restenosis (ISR), and there is some initial clinical evidence about their efficacy for the treatment of small coronary vessels. Newer-generation DCBs were developed to overcome the reduced deliverability of the previous generation, also warranting a more effective drug delivery to vessel wall. However, the vast majority of new-generation DCBs still lack of reliability due to paucity of clinical data...
February 9, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29428458/routine-angiographic-follow-up-versus-clinical-follow-up-in-patients-with-diabetes-following-percutaneous-coronary-intervention-with-drug-eluting-stents-in-korean-population
#10
Yong Hoon Kim, Ae-Young Her, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Yoonji Park, Man Jong Baek, Yang Gi Ryu, Ahmed Mashaly, Won Young Jang, Woohyeun Kim, Eun Jin Park, Jah Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Seung-Woon Rha
AIMS: The usefulness of routine angiographic follow-up (RAF) and clinical follow-up (CF) after percutaneous coronary intervention (PCI) in patients with diabetes is not well understood. We compare 3-year clinical outcomes of RAF and CF in diabetic patients underwent PCI with drug-eluting stents (DES). METHODS: A total of 843 patients with diabetes who underwent PCI with DES were enrolled. RAF was performed at 6 to 9 months after PCI (n=426). Rest of patients were medically managed and clinically followed (n=417); symptom-driven events were captured...
February 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29426631/outcomes-of-a-novel-thin-strut-bioresorbable-polymer-sirolimus-eluting-stent-in-patients-with-chronic-total-occlusions-a-multicenter-registry
#11
Lorenzo Azzalini, Ozan M Demir, Gabriele L Gasparini, Luca Grancini, Alessio La Manna, Soledad Ojeda, Susanna Benincasa, Barbara Bellini, Enrico Poletti, Davide Maccagni, Margherita Soldi, Loredana Iannetta, Daniela Trabattoni, Giacomo Gravina, Francisco Hidalgo, Francesco Giannini, Manuel Pan, Corrado Tamburino, Antonio L Bartorelli, Bernhard Reimers, Cosmo Godino, Mauro Carlino, Antonio Colombo
BACKGROUND: We aimed to evaluate the mid-term outcomes of a novel thin-strut bioresorbable-polymer sirolimus-eluting stent (BP-SES) in chronic total occlusion (CTO) percutaneous coronary intervention (PCI), as compared with durable-polymer everolimus-eluting stents (EES). METHODS: We compiled a multicenter registry of patients undergoing CTO recanalization followed by BP-SES or EES implantation. The primary endpoint was the incidence of target-lesion failure (TLF, a composite of cardiac death, target-vessel myocardial infarction, and target-lesion revascularization) at one year...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29415314/a-patient-with-lower-gastrointestinal-bleeding-common-history-very-uncommon-cause-minimally-invasive-treatment
#12
Guntram Lock, Thies Daniels, Lars Kock
An 81-year-old patient with significant cardiac comorbidities, a history of sigmoid resection 6 years ago, and iliac bypass surgery 19 years ago presented with mild hematochezia for the previous 3 days. While hemodynamically stable at first, he developed massive bleeding during preparation for colonoscopy and underwent a short course of cardiopulmonary resuscitation. Colonoscopy revealed no active bleeding but a protuberance of the colonic wall and a coagulation clot. In ultrasonography immediately after endoscopy, a large aneurysm was diagnosed and diagnosis of an iliaco-colonic fistula was assumed...
February 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29408354/increased-gradients-after-aortic-valve-replacement-with-the-perceval-valve-the-role-of-oversizing
#13
Alfredo Giuseppe Cerillo, Francesca Amoretti, Massimiliano Mariani, Emanuele Cigala, Michele Murzi, Tommaso Gasbarri, Marco Solinas, Dante Chiappino
BACKGROUND: Significant underexpansion or distortion of valved stents may be associated with altered leaflet function, leading to increased transprosthetic gradients and, possibly, early structural degeneration. We investigated the relationship between a computed tomography (CT) measure of the degree of oversizing and the early haemodynamic and clinical outcomes in patients undergoing aortic valve replacement with the Perceval sutureless aortic valve. METHODS: The degree of oversizing of the implanted prosthesis was calculated as the ratio between the patients' aortic annulus cross-sectional area (CSA) and the ex-vivo CSA of the implanted prosthesis in 151 perceval patients that had a preoperative cardiac CT...
February 2, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29407132/comparison-of-mid-term-clinical-outcomes-after-treatment-of-ostial-right-coronary-artery-lesions-with-early-and-new-generation-drug-eluting-stents-insights-from-an-international-multicenter-registry
#14
Satoru Mitomo, Richard J Jabbour, Yusuke Watanabe, Antonio Mangieri, Marco Ancona, Damiano Regazzoli, Akihito Tanaka, Akihiro Nakajima, Toru Naganuma, Francesco Giannini, Azeem Latib, Sunao Nakamura, Antonio Colombo
BACKGROUND: There are only a limited number of studies comparing clinical outcomes after treatment of right coronary artery (RCA) aorto-ostial (AO) lesions with early (E-) and new (N-) generation drug-eluting stents (DES). METHODS: From January 2005 to December 2013, 334 de novo RCA AO lesions treated with DES (E-:142 lesions, N-:192 lesions) at 2 high-volume centers (Italy and Japan) were included in this study. The primary endpoint was target lesion failure (TLF) defined as composite of cardiac mortality, target vessel myocardial infarction, and target lesion revascularization (TLR)...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29405596/hybrid-coronary-revascularization-time-for-a-new-comparator
#15
EDITORIAL
Naoki Misumida, David J Moliterno
The present meta-analysis found no significant difference between hybrid coronary revascularization (HCR) and bypass surgery (CABG) regarding intermediate-term major adverse cardiac and cerebrovascular events. HCR is feasible, historically with higher revascularization rates but less perioperative morbidity With a comparable frequency of repeat revascularization between current-generation drug-eluting stents and CABG, future trials of HCR are considering multi-vessel PCI as the new comparator.
February 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29399998/association-of-stent-induced-changes-in-coronary-geometry-with-late-stent-failure-insights-from-three-dimensional-quantitative-coronary-angiographic-analysis
#16
Bu Chun Zhang, Sheng Xian Tu, Antonios Karanasos, Robert-Jan van Geuns, Peter de Jaegere, Felix Zijlstra, Evelyn Regar
BACKGROUND: The relationship between vessel angulation and large changes in vessel geometry after stent implantation and the occurrence of stent failure still remains unclear. We sought to investigate the association of the change in the coronary bending angle after stenting and the risk for late stent failure by three-dimensional quantitative coronary angiography (3D QCA). METHODS: The bending angle in coronary lesions that presented with late stent failure and those without stent failure was computed during the cardiac cycle, before and after stenting using a recently developed 3D QCA software...
February 5, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29399567/safety-and-efficacy-of-the-endeavor-resolute%C3%A2-stent-in-patients-with-multivessel-disease-the-heart-honam-endeavor-resolute-prospective-multicenter-trial
#17
Doo Sun Sim, Myung Ho Jeong, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Keun Ho Park, Sun Ho Hwang, Dong Goo Kang, Seung Uk Lee, Joon Woo Kim, Jong Pil Park, Jay Young Rhew, Sang Rok Lee, Jei Keon Chae, Kyeong Ho Yun, Seok Kyu Oh, Won You Kang, Su Hyun Kim, Jang Hyun Cho
The Endeavor Resolute® (ER) is a zotarolimus-eluting stent (ZES) with a biocompatible BioLinx polymer. This study prospectively compared the clinical outcomes of 2 versions of ZES, ER and Endeavor Sprint® (ES), in patients with multivessel disease. A total of 488 patients who underwent multivessel percutaneous coronary intervention (PCI) were divided into 2 groups the ER group (n=288) and the ES group (n=200). The primary endpoint was a composite of major adverse cardiac events (MACE) consisting of death, myocardial infarction, and target vessel revascularization after 12 months...
January 2018: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29398632/transradial-experience-with-bioresorbable-vascular-scaffolds-a-case-matched-study-with-metallic-drug-eluting-stents
#18
Frédéric Maes, Olivier Costerousse, Tomas Cieza, Mélaine Henry, Jean-Pierre Déry, Gérald Barbeau, Robert Delarochellière, Jean-Michel Paradis, Eric Larose, Can M Nguyen, Charles Pirlet, Rosaire Mongrain, Olivier F Bertrand
BACKGROUND: Whether polymeric bioresorbable vascular scaffolds (BVS) implantation with transradial approach is feasible and safe is unknown. We compared the feasibility and safety of the transradial approach for BVS delivery with metallic drug-eluting stents (DES). METHODS: We identified 118 consecutive patients who underwent BVS implantation and we compared 30-days and 1-year results with 118 matched patients with DES. Patients were matched for age, sex, risk factors and clinical indication...
January 6, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29397139/management-of-antiplatelet-therapy-in-patients-with-coronary-stents-undergoing-noncardiac-surgery-association-with-adverse-events
#19
A Rodriguez, N Guilera, A Mases, P Sierra, J C Oliva, C Colilles
BACKGROUND: Perioperative discontinuation of antiplatelet therapy (APT) in patients with coronary stents has been associated with major adverse cardiac events. Our aim was to analyse the perioperative management of APT in such patients and its relationship to the incidence of major adverse cardiac and cerebrovascular events (MACCE) and major bleeding events (MBE) in noncardiac surgery. METHODS: We completed a prospective multicentre observational study of patients with coronary stents undergoing noncardiac surgery in 11 hospitals in Spain...
January 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29395703/long-term-outcomes-of-percutaneous-coronary-intervention-for-chronic-total-occlusion-in-patients-who-have-undergone-coronary-artery-bypass-grafting-vs-those-who-have-not
#20
Lorenzo Azzalini, Soledad Ojeda, Aris Karatasakis, Joren Maeremans, Masaki Tanabe, Alessio La Manna, Rustem Dautov, Luiz F Ybarra, Susanna Benincasa, Barbara Bellini, Luciano Candilio, Ozan M Demir, Francisco Hidalgo, Judit Karacsonyi, Giacomo Gravina, Eligio Miccichè, Guido D'Agosta, Giuseppe Venuti, Corrado Tamburino, Manuel Pan, Mauro Carlino, Joseph Dens, Emmanouil S Brilakis, Antonio Colombo, Stéphane Rinfret
BACKGROUND: We aimed to investigate the procedural and long-term outcomes of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in patients who had undergone previous coronary artery bypass grafting (CABG) vs those who had not, and to evaluate the role of the Registry of CrossBoss and Hybrid procedures in France, the Netherlands, Belgium, and United Kingdom (RECHARGE) score in predicting acute and long-term outcomes. METHODS: We compiled a multicentre registry of consecutive patients undergoing CTO PCI at 7 centres between January 2009 and April 2017...
December 26, 2017: Canadian Journal of Cardiology
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