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Tongda Li, Dongmei Li, Hui Xu, Huamin Zhang, Danli Tang, Hongxin Cao
BACKGROUND: Nitric oxide (NO) is the most powerful vasodilator that inhibits leukocyte adhesion, platelet aggregation, and vascular smooth muscle cell proliferation. However, excessive NO can cause lipid peroxidation and direct endothelial cell damage. Therefore, investigation of the role of NO in artherosclerosis development is important. Wen-Xin Decoction (WXD) has been shown to relieve myocardial ischemia reperfusion injury and prevent leukocyte adhesion and invasion; in addition, it can accelerate angiogenesis and prevent platelet activation and aggregation...
2016: BMC Complementary and Alternative Medicine
Jesús Millán Núñez-Cortés, Teresa Mantilla Morató, Rocio Toro, Joaquín Millán Pérez, Alipio Mangas Rojas
INTRODUCTION: hypertriglyceridemic waist phenotype has been associated with metabolic syndrome. OBJETIVES: in the present work has been raised to study the relationship between hypertriglyceridemic waist phenotype and metabolic syndrome as well as other metabolic risk factors. And finally, assess whether it is associated with an increased cardiovascular risk. METHODS: this study was conducted recruiting patients in a national registry of hypertriglyceridemia of the Spanish Society of Artherosclerosis...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Dongmei Zhang, Damin Yuan, Jianhong Shen, Yaohua Yan, Chen Gong, Jun Gu, Huaqing Xue, Yuhang Qian, Weidong Zhang, Xiaojuan He, Li Yao, Yuhong Ji, Aiguo Shen
Vascular cell adhesion molecule 1 (VCAM1) is a member of the Immunoglobulin superfamily and encodes a cell surface sialoglycoprotein expressed in cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion, facilitates the downstream signaling, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Accumulating evidence has demonstrated that VCAM1 exerts an anti-apoptotic effect in several tumor tissues such as ovarian cancer and breast cancer...
May 2015: Neurochemical Research
Rudolf Schicho, Gunther Marsche, Martin Storr
Over the past years, a growing number of studies have indicated that patients suffering from inflammatory bowel disease (IBD) have an increased risk of developing cardiovascular disease. Both are chronic inflammatory diseases and share certain pathophysiological mechanisms that may influence each other. High levels of cytokines, C-reactive protein (CRP), and homocysteine in IBD patients may lead to endothelial dysfunction, an early sign of atherosclerosis. IBD patients, in general, do not show the typical risk factors for cardiovascular disease but changes in lipid profiles similar to the ones seen in cardiovascular events have been reported recently...
2015: Current Drug Targets
Wendan Yuan, Wei Liu, Jingmin Li, Xiaoyan Li, Xuhong Sun, Fang Xu, Xuejing Man, Qiang Fu
In this study an in vitro model of simulated blood vessel injury was used to study the effects of bone marrow-derived mesenchymal stem cells (BMSCs) morphology and to detect vascular smooth muscle actin (SM α-actin) expression in the presence of adventitial fibroblasts. BMSCs from rats with DAPI-labeled nuclei were co-cultured with adventitial fibroblasts for 7 days, while BMSCs cultured alone served as controls. Cell morphology of BMSCs was assessed by laser confocal microscopy and SM α-actin or calponin expression in BMSCs was detected by immunofluorescence staining...
2014: International Journal of Clinical and Experimental Pathology
C Chaabane, C Brun, A Roatti, S Konig, Y Audigier, Aj Baertschi, Ml Bochaton-Piallat
BACKGROUND: Apelin, and its receptor APJ, are a peptidic system playing a crucial role in vascular diseases. However, the role of apelin in atherogenesis and smooth muscle cell (SMC) proliferation remains unclear. We isolated 2 distinct SMC phenotypes from porcine coronary artery: spindle-shaped (S) and rhomboid (R). Biological features of R-SMCs (i.e. enhanced proliferative and migratory activities as well as poor level of differentiation) explain their capacity to accumulate into the intima...
July 15, 2014: Cardiovascular Research
Tomasz Bereza, Krzysztof Tomaszewski, Janusz Skrzat, Wieslawa Klimek-Piotrowska, Mateusz Sporek, Ewa Mizia, Grzegorz Lis, Artur Pasternak
AIM: Aim of this study was to assess the quality of the corrosion specimens obtained during autopsies of human body for scanning electron microscopy procedures. MATERIALS AND METHOD: Ninety seven uteri were obtained upon autopsy of women aged 25-56 years, deceased due to causes not related to disorders of the reproductive system. Fourty three of them contained large subserosal uterine leiomyomata. twenty uteri were injected with acrylic emulsion Liquitex R via the arteries or veins...
2013: Folia Medica Cracoviensia
Jinbao Zhang, Pengwei Zhuang, Zhiqiang Lu, Mixia Zhang, Teng Zhang, Yanjun Zhang, Jinlei Wang, Dan Liu, Yongling Tong
: Suxiaojiuxin pill (SX) is a famous Chinese formulated product, which has been used to treat coronary heart disease and angina pectoris in China. This study was carried out to investigate the effect and possible mechanism of SX on the stability of atherosclerotic plaque in ApoE-deficient mice. ApoE-/- mice of 6-8 weeks old were fed with high-fat diet for developing artherosclerosis. After oral administration of SX for 8 weeks, histopathology of aortic plaque was performed by Sudan III and hematoxylin-eosin staining, and muscle protein was detected by Western blotting (WB)...
August 2014: Journal of Cardiovascular Pharmacology
Feyza Aksu, Fatih Ozçelik, Hakan Kunduracilar, Ahmet Barutçu, Mesih Yel, Elif Gülsüm Umit, Armağan Altun
BACKGROUND: Osteoprotegerin (OPG), an inhibitor of osteoclastogenesis, has recently been under the spotlight in studies regarding the pathophysiology of atherosclerosis. AIM: To evaluate the value of serum OPG in the diagnosis and severity in patients with stable angina pectoris (SA) and unstable angina pectoris/non ST elevation myocardial infarction. METHODS: This study involved 160 patients, SA (n = 65), acute coronary syndrome (NSTE-ACS; n = 65), and a control group (n = 30)...
2014: Kardiologia Polska
Umi Kalthum Md Noh, Amin Ahem, Mushawiahti Mustapha
Uncontrolled hypertension is well- known to give rise to systemic complications involving multiple central organs. Artherosclerosis leads to damage of the retinal vessels wall, contributing to venous stasis, thrombosis and finally, occlusion. Retinal vein occlusions compromise vision through development of ischaemic maculopathy, macular oedema, and rubeotic glaucoma. Laser photocoagulation remains the definitive treatment for ischaemic vein occlusion with secondary neovascularization. Timely treatment with anti- vascular endothelial growth factor prevents development of rubeotic glaucoma...
2013: Acta Medica Iranica
Mengquan Li, Yue Guan, Jiaqi Liu, Fengguo Zhai, Xiuping Zhang, Lixin Guan
BACKGROUND/AIMS: Total saponin extracted from Tribulus terrestris (TSETT) has been reported to protect against atherosclerosis. We here investigate the cellular and molecular mechanisms of TSETT underlying protection against atherosclerosis. METHODS: Cell proliferation was measured with Methyl thiazolyl tetrazolium (MTT); Intracellular H2O2 was measured with DCFH-DA, a fluorescent dye; Intracellular free Ca(2+) was measured with a confocal laser scanning microscopy; Genes expression was measured with gene array and real-time quantitative polymerase chain reaction (RT-PCR); Phosphorylation of extracellular signal-regulated kinase 1/2 (phospho-ERK1/2) was measured with cell-based enzyme-linked immunosorbent assay (ELISA) and western blotting...
2013: Cellular Physiology and Biochemistry
Isabel De Castro-Orós, Miguel Pocoví, Fernando Civeira
Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism characterized by high plasma concentrations of low-density lipoprotein cholesterol (LDLc), tendon xanthomas, and increased risk of premature coronary heart disease. FH is one of the most common inherited disorders; there are 10,000,000 people with FH worldwide, mainly heterozygotes. The most common FH cause is mutations along the entire gene that encode for LDL receptor (LDLR) protein, but it has been also described that mutations in apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 genes produce this phenotype...
2010: Application of Clinical Genetics
Sandra Siehler
G-protein-coupled receptors (GPCRs) transmit extracellular signals across the plasma membrane via intracellular activation of heterotrimeric G proteins. The signal transduction pathways of Gs, Gi and Gq protein families are widely studied, whereas signaling properties of G12 proteins are only emerging. Many GPCRs were found to couple to G12/13 proteins in addition to coupling to one or more other types of G proteins. G12/13 proteins couple GPCRs to activation of the small monomeric GTPase RhoA. Activation of RhoA modulates various downstream effector systems relevant to diseases such as hypertension, artherosclerosis, asthma and cancer...
December 2007: Expert Opinion on Drug Discovery
Peter Uciechowski, Eva Maria Oellig, Erminia Mariani, Marco Malavolta, Eugenio Mocchegiani, Lothar Rink
UNLABELLED: HASH(0x36b1d10) BACKGROUND: Advanced age results in crucial alterations of the innate and adaptive immune system leading to functional defects resulting in infection and chronic diseases. Toll-like receptors (TLR) recognize pathogenic structures and are important in the immune response to infections and vaccination. However, the role of TLR single nucleotide polymorphisms (SNP) is poorly understood in the setting of human ageing. This study investigated the impact of the TLR1 SNPs A743G and T1805G on ageing in different age groups from two European populations...
2013: Immunity & Ageing: I & A
Luis García-Olmos, Angel Alberquilla, Victoria Ayala, Pilar García-Sagredo, Leticia Morales, Montserrat Carmona, María José de Tena-Dávila, Mario Pascual, Adolfo Muñoz, Carlos H Salvador, Jose L Monteagudo
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is frequent and often coexists with other diseases. The aim of this study was to quantify the prevalence of COPD and related chronic comorbidity among patients aged over 40 years visiting family practices in an area of Madrid. METHODS: An observational, descriptive, cross-sectional study was conducted in a health area of the Madrid Autonomous Region (Comunidad Autónoma de Madrid). The practice population totalled 198,670 persons attended by 129 Family Physicians (FPs), and the study population was made up of persons over the age of 40 years drawn from this practice population...
2013: BMC Family Practice
Sudha S Deo, Arun R Chogle, Kejal J Mistry, Rashmi R Shetty, Umakant L Nadkar
BACKGROUND: Studies have shown that rheumatoid arthritis (RA) patients are two to five times more likely to develop premature cardiovascular disease, thus shortening their life expectancy by five to 10 years. This risk has risen to approximately 12.6% in the urban population and 7.4% in the rural population of India. The Framingham risk score (FRS) identifies patients at increased cardiovascular risk and helps determine the need for preventive interventions. An investigation of the patients' coronary arteries and coronary artery calcification (CAC) - a measure of atherosclerotic plaque - has been found to be a strong predictor of cardiovascular disease...
2012: Experimental and Clinical Cardiology
Yueying Ma, Jianxun Liu, Peng Li, Sheng Zhu, Chengren Lin
OBJECTIVE: To observe the protective effect of serum containing Tanyu Tongzhi formula (TYTZF) on ox-LDL-induced human umbilical vein endothelial cells (HUVECs) injury and detect its mechanism on anti-artherosclerosis. METHOD: HUVECs were pretreated with serum containing TYTZF and simvastatin respectively for 2 hours and then added with 100 mg x L(-1) of ox-LDL and laid aside for 24 hours. The activity of HUVECs were measured by the methyl thiazolyl tetrazolium (MTF) method and the NO content in cell culture supernatants were examined by the Griess method...
April 2012: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ding-Zhu Shen, Chuan Chen, Hui-Ying Chi
Atherosclerosis, a chronic degenerative disease mainly attacks the middle-aged and the aged population as they grow old. Anti-angiocellular aging has gradually become a new strategy for atherosclerosis. In the process of atherosclerosis developing, endothelial cell renewing is speeding. Various biological function disorders that induce blood vessel aging emerge, which leads to changes of the telomere and telomerase, resulting in aged endothelial cells and dysfunction. Telomere and telomerase may play key roles in the etiological factors such as inflammation and AS plaque...
February 2012: Chinese Journal of Integrated Traditional and Western Medicine
Stanisław Niemczyk, Katarzyna Romejko-Ciepielewska, Longin Niemczyk
The authors discussed disorders in adipocytokines' function in chronic renal failure (CRF) and their clinical implications. Adipocytokines' concentrations in CRF are in most cases elevated, which is associated with decreased level of their excretion. This may cause number of clinical implications such as inflammation, loss of appetite, development of protein energy wasting (PEW) syndrome and the progress of artherosclerosis, what leads to increased mortality in a group of patients with end-stage renal disease (ESRD)...
2012: Endokrynologia Polska
Helge Frieling, Viktoria Leitmeier, Mani Haschemi-Nassab, Johannes Kornhuber, Mathias Rhein, Stefan Bleich, Thomas Hillemacher
Asymmetric di-methylarginine, an endogenous inhibitor of nitric oxide synthase, is increasingly recognized as vascular risk factor. Elevated ADMA levels have been described not only in 'typical' vascular diseases like congestive heart failure, artherosclerosis and diabetes but also for major depression and Alzheimer's disease. As homocysteine increases ADMA levels and elevated homocysteine serum levels are present in patients with alcohol dependence, the aim of the present study was to examine plasma ADMA levels in patients with alcohol dependence during withdrawal...
November 2012: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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