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Chronic kidney disease state of art

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https://www.readbyqxmd.com/read/27835681/cognitive-performance-is-highly-stable-over-a-2-year-follow-up-in-chronic-kidney-disease-patients-in-a-dedicated-medical-environment
#1
Janine Gronewold, Olga Todica, Ulla K Seidel, Michaela Volsek, Andreas Kribben, Heike Bruck, Dirk M Hermann
BACKGROUND: As kidney and brain functions decline with aging, chronic kidney disease (CKD) and dementia are becoming increasing health burdens worldwide. Among the risk factors for cognitive impairment, CKD is increasingly recognized. The precise impact of CKD on the development of cognitive impairment is poorly understood. METHODS: In the New Tools for the Prevention of Cardiovascular Disease in Chronic Kidney Disease (NTCVD) cohort, which was recruited in a dedicated nephrology department, we examined the 2-year course of cognitive performance in 120 patients (73 patients with CKD stages 3-5D, 47 control patients without CKD with similar vascular risk profile) using a comprehensive battery of 10 neuropsychological tests...
2016: PloS One
https://www.readbyqxmd.com/read/27717781/1-3-%C3%A3-d-glucan-testing-is-highly-specific-in-patients-undergoing-dialysis-treatment
#2
Juergen Prattes, Daniel Schneditz, Florian Prueller, Eva Jaindl, Notburga Sauseng, Martin Hoenigl, Gernot Schilcher, Robert Krause
BACKGROUND: The aim of this combined in-vitro and in-vivo study was to investigate whether state of the art dialysis modalities produce false positive serum 1,3-ß-d-Glucan (BDG) levels. METHODS: Dialysis fluid for simulated dialysis treatments was spiked with BDG from different sources. Samples were taken from the dialysate and dialyzer blood compartments at various time points. In addition, serum samples were obtained in three groups of patients without invasive fungal disease: a...
October 4, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27647650/-andrologic-consequences-of-chronic-renal-failure-state-of-the-art-for-the-yearly-scientific-report-of-the-french-national-association-of-urology
#3
Y Neuzillet, R Thuret, F Kleinclauss, M-O Timsit
OBJECTIVE: To describe the state of the art of current knowledge regarding gonadal consequences of end-stage chronic kidney disease (CKD) and renal transplantation. MATERIAL AND METHOD: A systematic review of the literature search was performed from the databases Medline (NLM, Pubmed) and Embase, focused on the following keywords: "chronic kidney disease"; "chronic renal failure"; "hypogonadism"; "kidney transplantation"; "testicular dysfunction"; "testosterone"...
September 16, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27565581/the-role-of-the-gut-microbiome-on-chronic-kidney-disease
#4
B Sampaio-Maia, L Simões-Silva, M Pestana, R Araujo, I J Soares-Silva
Chronic kidney disease (CKD) is estimated to affect nearly 500 million people worldwide and cardiovascular (CV) disease is a major cause of death in this population. However, therapeutic interventions targeting traditional CV risks are not effective at lowering the incidence of CV events or at delaying the progression of the disease in CKD patients. In recent years, disturbances of normal gut microbiome were recognized in the pathogenesis of diverse chronic diseases. Gut dysbiosis is being unraveled in CKD and pointed as a nontraditional risk factor for CV risk and CKD progression...
2016: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/27458559/update-on-kidney-transplantation-in-human-immunodeficiency-virus-infected-recipients
#5
REVIEW
Khaled Nashar, Kalathil K Sureshkumar
Improved survival of human immunodeficiency virus (HIV) infected patients with chronic kidney disease following the introduction of antiretroviral therapy resulted in the need to revisit the topic of kidney transplantation in these patients. Large cohort studies have demonstrated favorable outcomes and proved that transplantation is a viable therapeutic option. However, HIV-infected recipients had higher rates of rejection. Immunosuppressive therapy did not negatively impact the course of HIV infection. Some of the immunosuppressive drugs used following transplantation exhibit antiretroviral effects...
July 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/26839638/advances-in-hepatitis-c-therapy-what-is-the-current-state-what-come-s-next
#6
REVIEW
Steffen Zopf, Andreas E Kremer, Markus F Neurath, Juergen Siebler
Chronic hepatitis C virus (HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease. It is only a few years ago that standard treatment regimes were based on pegylated interferon alpha and ribavirin. However, treatment of HCV has undergone a revolutionary change in recent years. The admission of the nucleotide polymerase inhibitor Sofosbuvir enabled an interferon-free regimen with direct antiviral agents (DAA). Meanwhile seven DAAs are available and can be applied in several combinations for 8 to 24 wk depending on HCV genotype and patient characteristics such as cirrhosis and chronic renal failure...
January 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/26371526/medical-management-of-chronic-kidney-disease-in-the-renal-transplant-recipient
#7
REVIEW
Song Ching Ong, Robert S Gaston
PURPOSE OF REVIEW: An updated overview of the state-of-the-art approaches to the care of chronic kidney disease-related issues in renal transplant recipients. RECENT FINDINGS: These include the impact of immunosuppression therapy on kidney function, the management of cardiovascular risk, metabolic bone disease, and hematologic complications, with a focus on the care of the patient with a failing allograft. SUMMARY: A kidney transplant improves patient morbidity and mortality, but almost all transplant patients continue to have morbidity related to chronic kidney disease...
November 2015: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/26169430/neonatal-acute-kidney-injury
#8
REVIEW
David T Selewski, Jennifer R Charlton, Jennifer G Jetton, Ronnie Guillet, Maroun J Mhanna, David J Askenazi, Alison L Kent
In recent years, there have been significant advancements in our understanding of acute kidney injury (AKI) and its impact on outcomes across medicine. Research based on single-center cohorts suggests that neonatal AKI is very common and associated with poor outcomes. In this state-of-the-art review on neonatal AKI, we highlight the unique aspects of neonatal renal physiology, definition, risk factors, epidemiology, outcomes, evaluation, and management of AKI in neonates. The changes in renal function with gestational and chronologic age are described...
August 2015: Pediatrics
https://www.readbyqxmd.com/read/26080612/challenges-and-clinical-decision-making-in-hiv-to-hiv-transplantation-insights-from-the-hiv-literature
#9
REVIEW
B J Boyarsky, C M Durand, F J Palella, D L Segev
Life expectancy among HIV-infected (HIV+) individuals has improved dramatically with effective antiretroviral therapy. Consequently, chronic diseases such as end-stage liver and kidney disease are growing causes of morbidity and mortality. HIV+ individuals can have excellent outcomes after solid organ transplantation, and the need for transplantation in this population is increasing. However, there is a significant organ shortage, and HIV+ individuals experience higher mortality rates on transplant waitlists...
August 2015: American Journal of Transplantation
https://www.readbyqxmd.com/read/26046738/cardio-pulmonary-renal-interactions-a-multidisciplinary-approach
#10
REVIEW
Faeq Husain-Syed, Peter A McCullough, Horst-Walter Birk, Matthias Renker, Alessandra Brocca, Werner Seeger, Claudio Ronco
Over the past decade, science has greatly advanced our understanding of interdependent feedback mechanisms involving the heart, lung, and kidney. Organ injury is the consequence of maladaptive neurohormonal activation, oxidative stress, abnormal immune cell signaling, and a host of other mechanisms that precipitate adverse functional and structural changes. The presentation of interorgan crosstalk may include an acute, chronic, or acute on chronic timeframe. We review the current, state-of-the-art understanding of cardio-pulmonary-renal interactions and their related pathophysiology, perpetuating nature, and cycles of increased susceptibility and reciprocal progression...
June 9, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25863473/drug-induced-renal-damage-in-preterm-neonates-state-of-the-art-and-methods-for-early-detection
#11
REVIEW
Anna Girardi, Emanuel Raschi, Silvia Galletti, Elisabetta Poluzzi, Giacomo Faldella, Karel Allegaert, Fabrizio De Ponti
Only a small fraction of drugs widely used in neonatal intensive care units (NICU) are specifically authorized for this population. Even if unlicensed or off-label use is necessary, it is associated with increased adverse drug reactions, which must be carefully weighed against expected benefits. In particular, renal damage is frequent among preterm babies, and is considered a predisposing factor for the development of chronic kidney disease in adulthood. Apart from specific conditions affecting premature neonates (e...
June 2015: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/25801638/pro-urine-proteomics-as-a-liquid-kidney-biopsy-no-more-kidney-punctures
#12
Harald Mischak
In this article, the benefits of urinary proteomics in comparison with kidney biopsy are discussed. The majority of urinary proteins are generated by the kidney, hence the urinary proteome holds substantial information on the kidney, and assessment of the urinary proteome could be considered a 'liquid biopsy'. The main question is how well the information contained in the urinary proteome can be assessed today, if it is ready to be routinely used, and what are the advantages and possible disadvantages in comparison with current standards...
April 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25744703/bone-imaging-and-fracture-risk-assessment-in-kidney-disease
#13
REVIEW
Sophie A Jamal, Thomas L Nickolas
Fractures are more common and are associated with greater morbidity and morality in patients with kidney disease than in members of the general population. Thus, it is troubling that in chronic kidney disease (CKD) patients there has been a paradoxical increase in fracture rates over the past 20 years compared to the general population. Increased fracture incidence in CKD patients may be driven in part by the lack of screening for fracture risk. In the general population, dual energy X-ray absorptiometry (DXA) is the clinical standard to stratify fracture risk, and its use has contributed to decreases in fracture incidence...
June 2015: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/25672470/laboratory-diagnostics-of-chronic-kidney-disease-in-croatia-state-of-the-art
#14
Vanja Radišić Biljak, Lorena Honović, Jasminka Matica, Branka Knežević, Sanela Šimić Vojak
INTRODUCTION: Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease. In 2014, the Joint Croatian Working Group (JCWG) for laboratory diagnostic of CKD on the behalf of Croatian society of medical biochemistry and laboratory medicine (CSMBLM) and Croatian chamber of medical biochemists (CCMB) conducted a survey across Croatian medical-biochemistry laboratories to assess the current practice in this area of laboratory medicine...
2015: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/25573484/therapeutic-advances-in-the-treatment-of-polycystic-kidney-disease
#15
REVIEW
Cristian Riella, Peter G Czarnecki, Theodore I Steinman
The spectrum of polycystic kidney disease (PKD) comprises a family of inherited syndromes defined by renal cyst formation and growth, progressive renal function loss and variable extrarenal manifestations. The most common form, autosomal-dominant PKD is caused by mutations in one of two genes, PKD1 or PKD2. Recent developments in genomic and proteomic medicine have resulted in the discovery of novel genes implicated in the wide variety of less frequent, recessive PKD syndromes. Cysts are the disease, and overall cystic burden, measured by MRI as total kidney volume, is being established as the best available biomarker of disease progression...
2014: Nephron. Clinical Practice
https://www.readbyqxmd.com/read/25352843/state-of-the-art-in-the-treatment-of-systemic-vasculitides
#16
REVIEW
Raashid Ahmed Luqmani
Anti-neutrophil cytoplasm antibodies (ANCA) are associated with small vessel vasculitides (AASV) affecting the lungs and kidneys. Structured clinical assessment using the Birmingham Vasculitis Activity Score and Vasculitis Damage Index should form the basis of a treatment plan and be used to document progress, including relapse. Severe disease with organ or life threatening manifestations needs cyclophosphamide or rituximab, plus high dose glucocorticoids, followed by lower dose steroid plus azathioprine, or methotrexate...
2014: Frontiers in Immunology
https://www.readbyqxmd.com/read/25341357/the-role-of-cardiotonic-steroids-in-the-pathogenesis-of-cardiomyopathy-in-chronic-kidney-disease
#17
REVIEW
Davor Pavlovic
Cardiotonic steroids (CTS) are a new class of hormones that circulate in the blood and are divided into two distinct groups, cardenolides, such as ouabain and digoxin, and bufadienolides, such as marinobufagenin, telocinobufagin and bufalin. They have the ability to bind and inhibit the ubiquitous transport enzyme sodium potassium pump, thus regulating intracellular Na(+) concentration in every living cell. Although digoxin has been prescribed to heart failure patients for at least 200 years, the realization that CTS are endogenously produced has intensified research into their physiological and pathophysiological roles...
2014: Nephron. Clinical Practice
https://www.readbyqxmd.com/read/25242761/sclerostin-and-dickkopf-1-in-post-menopausal-renal-allograft-recipients
#18
P Tomei, G Zaza, S Granata, D Gatti, C Fraccarollo, L Gesualdo, L Boschiero, A Lupo
BACKGROUND: Age, pre-existing renal osteodistrophy, impaired renal function, and chronic use of immunosuppressive drugs are the main factors involved in the onset and development of bone metabolism disturbances and skeletal alterations occurring after renal transplantation. However, at the state of the art, no reports have analyzed the additional post-menopausal physiological mechanisms associated with the onset and development of bone complications in renal transplant recipients. METHODS: We measured by means of molecular strategies (enzyme-linked immunoassay, chemiluminescence) the serum levels of Sclerostin and Dickkopf-1 (DKK1), two major antagonists of the Wnt/β-catenin pathway, and several bone resorption/formation biomarkers (N-terminal procollagen type 1, bone-specific alkaline phosphatase, and serum C-terminal telopeptides of type I collagen) in 19 post-menopausal kidney transplant patients and 12 post-menopausal chronic kidney disease patients (CKD group) matched for age and renal function...
September 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/24931712/pre-clinical-functional-magnetic-resonance-imaging-part-i-the-kidney
#19
REVIEW
Frank G Zöllner, Raffi Kalayciyan, Jorge Chacón-Caldera, Fabian Zimmer, Lothar R Schad
The prevalence of chronic kidney disease (CKD) is increasing worldwide. In Europe alone, at least 8% of the population currently has some degree of CKD. CKD is associated with serious comorbidity, reduced life expectancy, and high economic costs; hence, the early detection and adequate treatment of kidney disease is important. Pre-clinical research can not only give insights into the mechanisms of the various kidney diseases but it also allows for investigating the outcome of new drugs developed to treat kidney disease...
December 2014: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/24867672/can-one-evaluate-bone-disease-in-chronic-kidney-disease-without-a-biopsy
#20
REVIEW
Revekka Babayev, Thomas L Nickolas
PURPOSE OF REVIEW: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a complex disorder of bone and mineral metabolism that results in an excess risk of fractures, cardiovascular events and mortality. The management of the bone disorder aspect of CKD-MBD may require bone biopsy to determine appropriate treatment strategies. However, it is unclear when biopsy may be necessary and whether or not state-of-the art imaging and serologic testing can supplant the bone biopsy as a tool to assist with management decisions...
July 2014: Current Opinion in Nephrology and Hypertension
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