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Lentigo maligna

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https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#1
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29778279/outcomes-after-surgical-resection-of-lower-eyelid-tumors-and-reconstruction-using-a-nasal-chondromucosal-graft-and-an-upper-eyelid-myocutaneous-flap
#2
S Lemaître, C Lévy-Gabriel, L Desjardins, M González-Candial, S Gardrat, R Dendale, N Cassoux, B Couturaud
INTRODUCTION: Surgical excision of large malignant lower eyelid tumors may cause important full-thickness eyelid defects. The reconstruction of such defects must restore the physiologic function of the eyelid and also re-establish an acceptable aesthetic result. MATERIALS AND METHODS: We report the outcomes of full-thickness excision of tumors extending over half of the horizontal lid length, followed by reconstruction using a nasal chondromucosal graft (coming from the ipsilateral ala of the nose) and an upper eyelid myocutaneous flap...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29746652/malignant-melanoma-metastatic-to-oligodendroglioma-case-report-and-literature-review-of-tumor-to-tumor-metastasis-to-gliomas
#3
Alexandra Giantini Larsen, Benjamin L Grannan, Christine K Lee, Matthew J Koch, Erik A Williams, Matthew P Frosch, Daniel P Cahill
Tumor-to-tumor metastasis is an uncommon phenomenon, and a metastasis from an extracranial donor tumor to an intracranial recipient tumor is extremely rare. In particular, there are only 14 cases reported in the literature that describe a tumor-to-tumor metastasis involving a glioma. We present a rare case of an 83-year-old man with an 11-year history of lentigo maligna melanoma who presented with impaired balance and cognitive slowing and was found to have rapid progression of a previously known indolent right frontal brain mass...
May 8, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29704275/the-smart-approach-feasibility-of-lentigo-maligna-superficial-margin-assessment-with-handheld-reflectance-confocal-microscopy-technology
#4
G Pellacani, N De Carvalho, S Ciardo, B Ferrari, A M Cesinaro, F Farnetani, S Bassoli, P Guitera, P Star, R Rawson, E Rossi, C Magnoni, G Gualdi, C Longo, A Scope
BACKGROUND: Lentigo maligna may be challenging to clear surgically. OBJECTIVE: To evaluate feasibility of using superficial skin cuts as RCM imaging anchors for attaining negative surgical margins in lentigo maligna. METHODS: Included patients presented with lentigo maligna near cosmetically-sensitive facial structures. We evaluated, with handheld-RCM, microscopic clearance of melanoma beyond its dermoscopically-detected edges. Evaluated margins were annotated using shallow skin-cuts...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29697423/using-stratum-corneum-thickness-and-configuration-to-distinguish-lichenoid-dermatoses
#5
Amanda F Marsch
BACKGROUND: Clues in the stratum corneum (SC) can aide in histopathologic diagnosis of many conditions. OBJECTIVE: To determine if SC configuration and thickness could help differentiate the lichenoid dermatoses. METHODS: A retrospective study was performed. A total of 305 cases (55 lichenoid keratosis, 51 lichen planus, 7 hypertrophic lichen planus, 40 lichenoid drug eruption, 19 lichenoid graft-vs.-host disease, 14 hypertrophic lupus, 46 lichenoid actinic keratosis, 73 lentigo maligna) fulfilled the selection criteria...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29693252/bedside-diagnosis-of-lentigo-maligna-with-reflectance-confocal-microscopy
#6
Raheel Zubair, Attiya Haroon, Babar Rao
Early diagnosis of lentigo maligna (LM) is both critical and challenging. Biopsy at some sites can be problematic for functional and cosmetic reasons. Small specimens introduce sampling error and false negatives as a result of their heterogeneity, which can include collision with benign lesions and amelanotic components that conceal true margins extending beyond the pigmented edge.(1-2) Diagnostic uncertainty causes unnecessary excisions of the benign imitators of lentigo maligna. These biopsies have a non-negligible surgical morbidity...
April 25, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29683288/lentigo-maligna-diagnosis-and-treatment
#7
Erika V De Luca, Francesca Perino, Alessandro Di Stefani, Valeria Coco, Barbara Fossati, Ketty Peris
Lentigo maligna (LM) is an in situ subtype of melanoma, clinically presenting as a pigmented, asymmetric macule that originates mostly on the head and neck and spreads slowly. The diagnosis may be challenging both for clinicians and pathologists. Dermatoscopy and reflectance confocal microscopy represent a useful tool in the differentiation of LM from other pigmented lesions, such as pigmented actinic keratosis, solar lentigines, seborrheic keratosis and lichen planus-like keratosis. Moreover, those non-invasive diagnostic technique may be crucial in the selection of optimal biopsy sites in equivocal lesions, in pre-surgical mapping and in evaluating and monitoring response to non-surgical treatments...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29620004/a-new-dermoscopic-algorithm-for-the-differential-diagnosis-of-facial-lentigo-maligna-and-pigmented-actinic-keratosis
#8
Tamara Micantonio, Luca Neri, Caterina Longo, Simone Grassi, Alessandro Di Stefani, Ambra Antonini, Valeria Coco, Maria Concetta Fargnoli, Giuseppe Argenziano, Ketty Peris
The clinical and dermoscopic diagnosis of facial lentigo maligna (LM) and pigmented actinic keratosis (PAK) remains challenging, particularly at the early disease stages. To identify dermoscopic criteria that might be useful to differentiate LM from PAK, and to elaborate and validate an automated diagnostic algorithm for facial LM/PAK. We performed a retrospective multicentre study to evaluate dermoscopic images of histologically-proven LM and PAK, and assess previously described dermoscopic criteria. In the first part of the study, 61 cases of LM and 74 PAK were examined and a parsimonious algorithm was elaborated using stepwise discriminant analysis...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29573292/in-vivo-reflectance-confocal-microscopy-combined-with-the-spaghetti-technique-for-the-identification-of-surgical-margins-of-lentigo-maligna-experience-in-70-patients
#9
Emmanuelle Couty, Linda Tognetti, Bruno Labeille, Catherine Douchet, Cyril Habougit, Caroline Couzan, Anne Catherine Biron-Schneider, Frédéric Cambazard, Virginie Prade, Pietro Rubegni, Elisa Cinotti, J L Perrot
Lentigo maligna (LM) and lentigo maligna melanoma (LMM) account for 10% of all melanomas and are mainly located on head and neck areas.1-4 Complete surgical excision is the recommended treatment. However, this treatment is often challenging because of LM/LMM location in the face and the difficulty in the identification of its surgical margins1-5 . Local recurrence of LM/LMM still represents a major concern with recurrence rates after conventional surgical excision of 8 to 20% of cases, up to 47% in absence of Mohs micrographic surgery (MMS)...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29543619/treatment-for-lentigo-maligna-of-the-head-and-neck-survey-of-practices-in-ontario-canada
#10
Annie Liu, Alexis Botkin, Christian Murray, David Goldstein, Stefan O P Hofer, Nowell Solish, Jessica Kitchen, An-Wen Chan
BACKGROUND: Lentigo maligna is an in situ form of cutaneous melanoma that commonly arises on the head and neck. Various surgical and nonsurgical treatment options are available but no randomized trials exist to guide practice. OBJECTIVE: To determine the current treatment practices for lentigo maligna of the head and neck in Ontario, Canada. MATERIALS AND METHODS: Cross-sectional survey of dermatologists, plastic surgeons, and head and neck surgeons...
March 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29453870/comparison-of-melanocyte-density-counts-in-topical-imiquimod-treated-skin-surrounding-lentigo-maligna-vs-control-biopsy-specimens
#11
Shadai Flores, Nathan J Luby, Glen M Bowen
No abstract text is available yet for this article.
April 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29430695/immunocryosurgery-as-monotherapy-for-lentigo-maligna-or-combined-with-surgical-excision-for-lentigo-maligna-melanoma
#12
Clara Matas-Nadal, Xavier Sòria, María R García-de-la-Fuente, Valentín Huerva, Eugenia Ortega, Felip Vilardell, Sònia Gatius, Josep M Casanova, Rosa M Martí
The incidence of lentigo maligna (LM), in situ (LM) or invasive (lentigo maligna melanoma, LMM), has increased during the last decades. Due to functional or cosmetic outcomes, optimal treatment with surgical excision may not be appropriate in some cases. We tried less invasive therapy, immunocryosurgery, as a single treatment for LM or combined with surgery for LMM, with better aesthetic results. Three patients with LM or LMM not amenable to complete surgical excision were selected. LMM patients underwent limited surgical resection of the invasive area...
May 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29419913/variation-in-the-diagnosis-and-clinical-management-of-lentigo-maligna-across-europe-a-survey-study-among-european-association-of-dermatologists-and-venereologists-members
#13
D Tio, C A C Prinsen, B Dréno, R Hoekzema, M Augustin, C van Montfrans
BACKGROUND: Lentigo maligna (LM), a form of melanoma in situ, is treated to prevent progression to lentigo maligna melanoma (LMM). Surgical treatment is the gold standard. However, treatment guidelines are based on expert opinion, and comparative studies are lacking. OBJECTIVE: The objective of this study was to assess the diagnostic methods and clinical management of LM patients among European dermatologists and residents. METHODS: A survey consisting of 29 questions about diagnostic methods and treatment options used for LM patients was sent to 3308 members of the European Association of Dermatologists and Venereologists (EADV)...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29388348/benign-and-malignant-collision-tumors-of-melanocytic-skin-lesions-with-hemangioma-dermoscopic-and-reflectance-confocal-microscopy-features
#14
L Tognetti, E Cinotti, J L Perrot, M Campoli, M Fimiani, P Rubegni
BACKGROUND: Though the combination/collision of nevi or lentigo simplex and hemangiomas is frequent, the malignant collision tumor melanoma-hemangioma is exceptional and can sometime clinically simulate a benign collision. To date, a series of collision tumors of hemangiomas associated with either benign or malignant melanocytic skin lesions (MSL) has yet to be studied by non-invasive imaging and clinico-pathologic correlates. METHODS: We present 10 cases of patients with collision tumors of hemangioma with different MSL including: 2 in situ lentigo-maligna melanoma, 1 invasive melanoma, 5 melanocytic nevi, and 2 lentigo simplex...
May 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29377079/incidence-of-diseases-primarily-affecting-the-skin-by-age-group-population-based-epidemiologic-study-in-olmsted-county-minnesota-and-comparison-with-age-specific-incidence-rates-worldwide
#15
REVIEW
Laurel L Wessman, Louise K Andersen, Mark D P Davis
Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature...
January 29, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29341263/dermoscopy-versus-reflectance-confocal-microscopy-for-the-diagnosis-of-lentigo-maligna
#16
E Cinotti, B Labeille, S Debarbieux, C Carrera, F Lacarrubba, A M Witkowski, E Moscarella, E Arzberger, H Kittler, P Bahadoran, S Gonzalez, P Guitera, M Agozzino, F Farnetani, R Hofmann-Wellenhof, M Ardigò, P Rubegni, L Tognetti, J Łudzik, I Zalaudek, G Argenziano, C Longo, S Ribero, J Malvehy, G Pellacani, F Cambazard, J L Perrot
BACKGROUND: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques. OBJECTIVE: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. METHODS: 223 facial lesions were evaluated by 21 experts. Diagnostic accuracy of the clinical, dermoscopic and RCM examination were compared...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29327697/an-unusual-early-onset-of-lentigo-maligna-in-the-fourth-decade-of-life
#17
Eftychia Platsidaki, Nikolaos Kostopoulos, Kanellos Gesakis, Dorothea Polydorou, Efthymia Agiasofitou
No abstract text is available yet for this article.
January 5, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29274094/folliculotropism-in-pigmented-facial-macules-differential-diagnosis-with-reflectance-confocal-microscopy
#18
Flavia Persechino, Nathalie De Carvalho, Silvana Ciardo, Barbara De Pace, Alice Casari, Johanna Chester, Shaniko Kaleci, Ignazio Stanganelli, Caterina Longo, Francesca Farnetani, Giovanni Pellacani
Pigmented facial macules are common on sun damage skin. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging. Reflectance confocal microscopy (RCM) has been proven to increase diagnostic accuracy of facial lesions. A total of 154 pigmented facial macules, retrospectively collected, were evaluated for the presence of already-described RCM features and new parameters depicting aspects of the follicle. Melanocytic nests, roundish pagetoid cells, follicular infiltration, bulgings from the follicles and many bright dendrites and infiltration of the hair follicle (ie, folliculotropism) were found to be indicative of LM/LMM compared to non-melanocytic skin neoplasms (NMSNs), with an overall sensitivity of 96% and specificity of 83%...
March 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29250646/timps-expression-in-lentigo-maligna%C3%A3-lentigo-maligna-melanoma-versus-aged-skin-a-review-of-the-literature-and-personal-experience
#19
Alice Brînzea, Roxana Ioana Nedelcu, Gabriela Turcu, Mihaela Antohe, Sabina Andrada Zurac, Daniela Adriana Ion
Mechanisms involved in melanoma invasiveness and metastasis are essential to understanding the behavior of this aggressive melanocytic skin cancer. The epithelial-mesenchymal transition (EMT) is considered fundamental for overcoming the in situ stage of melanoma and its proliferation beyond the basal membrane. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are key molecules involved in EMT about whose expression in lentigo maligna (LM) and lentigo maligna melanoma (LMM) little has been studied so far...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29194224/a-population-based-analysis-of-melanoma-of-the-external-ear
#20
Tapan D Patel, Oliver Y Chin, Soly Baredes, Jean Anderson Eloy, Yu-Lan Mary Ying
OBJECTIVE: Malignant melanoma accounts for nearly 75% of all skin cancer deaths, and the incidence is on the rise in the United States. External ear melanoma (EEM) is rare, and there is little long-term data regarding the clinical behavior of this melanoma site. This study analyzes the demographic, clinicopathologic, and survival characteristics of EEM. METHODS: The SEER database was queried for EEM cases from 1973 to 2012 (8,982 cases). Data analyzed included patient demographics, incidence trends, and survival outcomes...
February 2018: Otology & Neurotology
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