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Lentigo maligna

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https://www.readbyqxmd.com/read/28329643/epidemiology-of-lentigo-maligna-and-lentigo-maligna-melanoma-in-the-netherlands-1989-2013
#1
Karin Greveling, Marlies Wakkee, Tamar Nijsten, Renate R Vane den Bos, Loes M Hollestein
Lentigo maligna (LM) is considered a precursor to LM melanoma (LMM). We assessed trends in LM and LMM incidence rates between 1989 and 2013 in the Netherlands, and estimated the risk of a LMM after LM. Data on newly diagnosed LM and LMM were obtained from the Netherlands Cancer Registry and PALGA (Dutch Pathology Database). Age-standardized incidence rates (European standardized rate [ESR]), estimated annual percentage changes (EAPC), and the cumulative incidence of LMM after LM were calculated. Between 1989-2013, 10,545 patients were diagnosed with a primary LM and 2,898 with a primary LMM in the Netherlands...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28296789/locally-recurrent-lentigo-maligna-and-lentigo-maligna-melanoma-characteristics-and-time-to-recurrence-after-surgery
#2
Karen L Connolly, Brian P Hibler, Erica H Lee, Anthony M Rossi, Klaus J Busam, Kishwer S Nehal
BACKGROUND: Various studies have reported local recurrence (LR) rates after surgical treatment of lentigo maligna (LM) and lentigo maligna melanoma (LMM). However, the time to LR of LM/LMM is not currently known, as few studies report time to LR and have long-term follow-up. OBJECTIVE: To define time to LR in LM/LMM after surgical treatment, and to describe features of observed LR. MATERIALS AND METHODS: Retrospective single-center study of consecutive patients presenting with locally recurrent LM/LMM...
March 14, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28295169/characteristic-features-of-cutaneous-melanoma-in-a-dermatology-referral-centre-in-tehran-iran
#3
Kambiz Kamyab, Sheyda Kazemi, Pourya Azimi, Arghavan Azizpour, Narges Ghandi, Elham Pirooz, Pedram Noormohammadpour, Mostafa Mirshams-Shahshahani, Maryam Daneshpazhooh
BACKGROUND/OBJECTIVES: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran. METHODS: A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Clinical data included age and gender of the patients at the time of diagnosis, tumour location and tumour size. Histological characteristics included Breslow thickness, Clark level and subtype of tumour...
March 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28247492/lentigo-maligna-successfully-treated-with-combination-therapy-of-topical-tazarotene-and-imiquimod
#4
S Menzies, M Mc Menamin, R Barry
No abstract text is available yet for this article.
March 1, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28224656/diagnosis-and-management-of-lentigo-maligna-an-observational-study-comparing-2005-with-2014-data-in-one-institution
#5
S Hawkey, A Affleck
The incidence, clinical characteristics and management of lentigo maligna (LM) were assessed in a university hospital setting in 2005 and 2014. Multiple clinical variables were compared, and 28 and 43 cases, respectively were identified during the two time periods. The most common site of presentation was the cheek (50% vs. 44%), and an accurate clinical diagnosis of LM was made in 60% vs. 72%) of cases. Most of the patients received surgical treatment (75% in 2005 vs. 97% in 2014), with 47% and 33% of excisions, respectively, remaining involved at the peripheral surgical margin...
February 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28218469/diagnostic-accuracy-of-reflectance-confocal-microscopy-using-vivascope-for-detecting-and-monitoring-skin-lesions-a-systematic-review
#6
S J Edwards, G Osei-Assibey, R Patalay, V Wakefield, C Karner
BACKGROUND: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy. AIM: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins...
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28099598/dermatoscopy-guided-therapy-of-pigmented-basal-cell-carcinoma-with-imiquimod
#7
Husein Husein-ElAhmed, Maria Antonia Fernandez-Pugnaire
BACKGROUND: Dermatoscopy is a non-invasive diagnostic tool used to examine skin lesions with an optical magnification. It has been suggested as a useful tool for monitoring therapeutic response in lentigo maligna patients treated with imiquimod. OBJECTIVE: To examine the accuracy of dermatoscopy as a tool to monitor the therapeutic response of pigmented basal cell carcinoma treated with imiquimod. METHOD: The authors designed a prospective study...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27987308/a-systematic-review-on-the-role-of-imiquimod-in-lentigo-maligna-and-lentigo-maligna-melanoma-need-for-standardization-of-treatment-schedule-and-outcome-measures
#8
REVIEW
D Tio, J van der Woude, C A C Prinsen, E P Jansma, R Hoekzema, C van Montfrans
BACKGROUND: Lentigo maligna (LM) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma (LMM). METHODS: PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Articles were included if they described histologically proven LM treated with imiquimod 5% monotherapy or combined with another topical therapy...
December 17, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27926588/incidence-trends-and-clinical-pathological-characteristics-of-invasive-cutaneous-melanoma-from-1980-to-2010-in-the-canton-of-zurich-switzerland
#9
Remo Minini, Sabine Rohrmann, Ralph Braun, Dimitri Korol, Silvia Dehler
The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Incidence trends were age standardized to the European standard population...
December 6, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27906694/follicular-malignant-melanoma-a-rare-morphologic-variant-of-melanoma-report-of-a-case-and-review-of-the-literature
#10
Iona Chapman, Sharon Horton, Wenhua Liu
Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Criteria have been suggested to help distinguish FMM from lentigo maligna melanoma; however, no clear criteria distinguish this cancer clinically. FMM cannot be distinguished from follicular metastases of melanoma based on histology, requiring close clinical correlation and detailed history taking on the part of the practitioner...
November 29, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27898656/interval-cancers-after-skin-cancer-screening-incidence-tumour-characteristics-and-risk-factors-for-cutaneous-melanoma
#11
J Hübner, A Waldmann, A C Geller, M A Weinstock, N Eisemann, M Noftz, S Bertram, S Nolte, B Volkmer, R Greinert, E Breitbart, A Katalinic
BACKGROUND: The rate of interval cancers is an established indicator for the performance of a cancer-screening programme. METHODS: We examined the incidence, tumour characteristics and risk factors of melanoma interval cancers that occurred in participants of the SCREEN project, which was carried out 2003/2004 in Schleswig-Holstein, Germany. Data from 350 306 SCREEN participants, who had been screened negative for melanoma, were linked to data of the state cancer registry...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27873142/university-hospital-waterford-5-year-experience-of-cutaneous-melanoma
#12
R Sehgal, C X Cheung, R Alradadi, D A Healy, R Landers, G T O'Donoghue
INTRODUCTION: The incidence of cutaneous melanoma (CM) continues to rise in Ireland. Despite significant advances in melanoma molecular therapy, surgery remains the mainstay of treatment for CM. The University Hospital Waterford (UHW) prospectively maintained CM registry was established in 2010. AIM: To summarize 5-year experience (2010-2015) of primary CM presenting to UHW. METHODS: Data were retrospectively obtained from a central electronic pathology and radiology repository augmented by HIPE data and theatre logs...
November 21, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27728982/desmoplastic-melanoma-a-challenge-for-the-oncologist
#13
Marco Manfredini, Giovanni Pellacani, Lorena Losi, Monia Maccaferri, Aldo Tomasi, Giovanni Ponti
AIM: To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM). MATERIALS & METHODS: Analysis of all DM records from 1991 to 2015. RESULTS: The most common location of DMs was the head and neck (69%); median age and follow-up were 60.5 and 7.3 years, respectively. A familial predisposition for DMs and others malignancies was analyzed. Thin Breslow thickness (<4.5 mm) was associated with an intraepidermal component or a previous lentigo maligna, whereas high Breslow thickness (>4...
February 2017: Future Oncology
https://www.readbyqxmd.com/read/27714781/effect-of-topical-imiquimod-as-primary-treatment-for-lentigo-maligna-the-limit-1-study
#14
J R Marsden, R Fox, N M Boota, M Cook, K Wheatley, L Billingham, N Steven
BACKGROUND: Topical imiquimod is sometimes used for lentigo maligna (LM) in-situ melanoma instead of surgery, but frequency of cure is uncertain. Pathological complete regression (pCR) is a logical surrogate marker for cure after imiquimod, although residual LM and atypical melanocytic hyperplasia may not be reliably distinguished. A trial comparing imiquimod versus surgery might be justified by a high imiquimod pCR rate. OBJECTIVES: Primary: to estimate pCR rate for LM following imiquimod...
October 6, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27692455/in%C3%A2-vivo-and-ex%C3%A2-vivo-confocal-microscopy-for-dermatologic-and-mohs-surgeons
#15
REVIEW
Caterina Longo, Moira Ragazzi, Milind Rajadhyaksha, Kishwer Nehal, Antoni Bennassar, Giovanni Pellacani, Josep Malvehy Guilera
Confocal microscopy is a modern imaging device that has been extensively applied in skin oncology. More specifically, for tumor margin assessment, it has been used in two modalities: reflectance mode (in vivo on skin patient) and fluorescence mode (on freshly excised specimen). Although in vivo reflectance confocal microscopy is an add-on tool for lentigo maligna mapping, fluorescence confocal microscopy is far superior for basal cell carcinoma and squamous cell carcinoma margin assessment in the Mohs setting...
October 2016: Dermatologic Clinics
https://www.readbyqxmd.com/read/27692448/lentigo-maligna-macules-of-the-face-and-lesions-on-sun-damaged-skin-confocal-makes-the-difference
#16
REVIEW
Phoebe Star, Pascale Guitera
Distinguishing lentigo maligna (LM) and lentigo maligna melanoma (LMM) from background pigmented non-melanoma lesions is challenging. The field of solar damage can obscure clinical assessment, and diagnostic ambiguities are created due to the overlap of the clinical features of LM with other benign lesions. Moreover, margin assessment on histology is limited by the resemblance between melanocytic hyperplasia of actinically damaged skin and scattered atypical melanocytes of LM/LMM. Dermoscopy has made a significant contribution but is often not sufficient for diagnosis and margin assessment...
October 2016: Dermatologic Clinics
https://www.readbyqxmd.com/read/27692447/melanomas
#17
REVIEW
Caterina Longo, Giovanni Pellacani
Melanomas are a wide range of tumors that differ in their epidemiology, morphology, genetic profile, and biological behavior. They can be grouped as superficial spreading melanoma, lentigo maligna, and nodular melanoma. Reflectance confocal microscopy is useful for the evaluation of skin lesions that are dermoscopically doubtful by increasing diagnostic accuracy and specificity. This article provides a comprehensive overview of the different confocal main morphologies of distinct melanoma types as a function of the anatomic location of the tumor...
October 2016: Dermatologic Clinics
https://www.readbyqxmd.com/read/27689028/cutaneous-melanoma-in-asians
#18
REVIEW
Sang Yub Kim, Sook Jung Yun
Malignant melanoma is a rare disease in Asians but potentially the most aggressive form of skin cancer worldwide. It can occur in any melanocyte-containing anatomic site. Four main cutaneous melanoma subtypes are recognized: lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma (ALM), and nodular melanoma. Generally, excessive exposure to ultraviolet (UV) radiation increases the risk of melanoma. The exception is ALM, which is the most common melanoma subtype in Asians and is not associated with UV radiation...
September 2016: Chonnam Medical Journal
https://www.readbyqxmd.com/read/27640136/associations-between-childhood-height-and-morphologically-different-variants-of-melanoma-in-adulthood
#19
Kathrine Damm Meyle, Michael Gamborg, Lisbet Rosenkrantz Hölmich, Jennifer Lyn Baker
AIM OF THE STUDY: Melanoma subtypes have different aetiological characteristics. Child height is positively associated with adult melanoma; however, a clarification of associations with specific melanoma variants is necessary for an improved understanding of risk factors underlying the histologic entities. This study investigated associations between childhood height and future development of cutaneous melanoma variants. METHOD: A cohort study of 316,193 individuals from the Copenhagen School Health Records Register, with measured heights at ages 7-13 years who were born from 1930 to 1989...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27617721/segmental-neurofibromatosis-and-cancer-report-of-triple-malignancy-in-a-woman-with-mosaic-neurofibromatosis-1-and-review-of-neoplasms-in-segmental-neurofibromatosis
#20
Philip R Cohen
BackgroundSegmental neurofibromatosis, referred to as mosaic neurofibromatosis 1, patients present with neurofibromas or café au lait macules or both in a unilateral segment of the body.PurposeA woman with segmental neurofibromatosis and triple cancer (renal cell carcinoma, mixed thyroid carcinoma, and lentigo maligna) is described and cancers observed in patients with segmental neurofibromatosis are reviewed.MethodsPubMed was used to search the following terms, separately and in combination: cancer, malignancy, mosaic, neoplasm, neurofibroma, neurofibromatosis, segment, segmental, tumor...
July 15, 2016: Dermatology Online Journal
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