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https://www.readbyqxmd.com/read/28338488/respiratory-complications-management-and-treatments-for-neuromuscular-disease-in-children
#1
MyMy C Buu
PURPOSE OF REVIEW: To summarize current literature describing the respiratory complications of neuromuscular disease (NMD) and the effect of respiratory interventions and to explore new gene therapies for patients with NMD. RECENT FINDINGS: Measurements of respiratory function focus on vital capacity and maximal inspiratory and expiratory pressure and show decline over time. Management of respiratory complications includes lung volume recruitment, mechanical insufflation-exsufflation, chest physiotherapy and assisted ventilation...
March 23, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28334924/throat-swabs-in-children-with-respiratory-tract-infection-associations-with-clinical-presentation-and-potential-targets-for-point-of-care-testing
#2
Hannah V Thornton, Alastair D Hay, Niamh M Redmond, Sophie L Turnbull, Hannah Christensen, Tim J Peters, John P Leeming, Andrew Lovering, Barry Vipond, Peter Muir, Peter S Blair
Background and objectives.: Diagnostic uncertainty over respiratory tract infections (RTIs) in primary care contributes to over-prescribing of antibiotics and drives antibiotic resistance. If symptoms and signs predict respiratory tract microbiology, they could help clinicians target antibiotics to bacterial infection. This study aimed to determine relationships between symptoms and signs in children presenting to primary care and microbes from throat swabs. Methods.: Cross-sectional study of children ≥3 months to <16 years presenting with acute cough and RTI, with subset follow-up...
February 18, 2017: Family Practice
https://www.readbyqxmd.com/read/28332104/exhaustive-mathematical-analysis-of-simple-clinical-measurements-for-childhood-pneumonia-diagnosis
#3
Keegan Kosasih, Udantha Abeyratne
BACKGROUND: Pneumonia is the leading cause of mortality for children below 5 years of age. The majority of these occur in poor countries with limited access to diagnosis. The World Health Organization (WHO) criterion for pneumonia is the de facto method for diagnosis. It is designed targeting a high sensitivity and uses easy to measure parameters. The WHO criterion has poor specificity. METHODS: We propose a method using common measurements (including the WHO parameters) to diagnose pneumonia at high sensitivity and specificity...
March 22, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28327684/outbreak-investigation-of-influenza-in-pajaru-vdc-of-jajarkot-district-of-nepal
#4
S K Upadhyay, P M Singh Pradhan, R K Mahato, B Marasini, B Upadhyaya, G Shakya, G Baral, K P Baral
BACKGROUND: An outbreak investigation study was conducted in Pajaru, one of the initially affected Village Development Committees (VDCs) of the Jajarkot district in Nepal following an outbreak of respiratory illness in early 2015. The objectives of this study were to identify the cases and magnitude of the outbreak. METHODS: A cross-sectional study was carried out in mid-April 2015 covering five most affected wards of Pajaru VDC to assess the patients using standard case definition for Influenza like Illness (ILI)...
September 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28318199/-foreign-body-in-the-esophagus-as-a-cause-of-respiratory-symptoms-in-children-clinical-cases
#5
Giselle Cuestas, Verónica Rodríguez, Flavia Doormann, Patricio Bellia Munzón, Gastón Bellia Munzón
Foreign bodies in esophagus are avoidable accidents that occur most often in children younger than 3 years. The most common presenting symptoms are dysphagia, drooling and vomiting. Occasionally a foreign body in the esophagus may present with respiratory symptoms such as cough, stridor and respiratory distress. This is more common in young children and when the object remains lodged in the esophagus for a prolonged period. Clinical suspicion is essential for early diagnosis, which allows to avoid potential complications...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28316098/therapeutic-options-for-dysfunctional-breathing-in-children-and-adolescents
#6
Bodo Niggemann, Christine Lehmann, Dorothea Pfeiffer-Kascha, Christa Weiss
Dysfunctional breathing is common and represents important differential diagnoses for respiratory discomfort. Typical examples include habit cough, sighing dyspnoea, hyperventilation syndrome, dysfunctional breathing patterns or vocal cord dysfunction (1,2). Comorbidities are frequent, especially with bronchial asthma. In some cases dysfunctional breathing may be a sequelae of child neglect or abuse. This article is protected by copyright. All rights reserved.
March 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28301447/mercury-spill-responses-five-states-2012-2015
#7
Ryan J Wozniak, Anne E Hirsch, Christina R Bush, Stuart Schmitz, Jeff Wenzel
Despite measures to educate the public about the dangers of elemental mercury, spills continue to occur in homes, schools, health care facilities, and other settings, endangering the public's health and requiring costly cleanup. Mercury is most efficiently absorbed by the lungs, and exposure to high levels of mercury vapor after a release can cause cough, sore throat, shortness of breath, nausea, vomiting, diarrhea, headaches, and visual disturbances (1). Children and fetuses are most susceptible to the adverse effects of mercury vapor exposure...
March 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28296782/the-safety-and-efficacy-of-dexmedetomidine-remifentanil-in-children-undergoing-flexible-bronchoscopy-a-retrospective-dose-finding-trial
#8
Xia Li, Xue Wang, Shuguang Jin, Dongsheng Zhang, Yanuo Li
Flexible bronchoscopy is more and more used for diagnosis and management of various pulmonary diseases in pediatrics. As poor coordination of children, the procedure is usually performed under general anesthesia with spontaneous or controlled ventilation to increase children and bronchoscopists' safety and comfort. Previous studies have reported that dexmedetomidine (DEX) could be safely and effectively used for flexible bronchoscopy in both adulate and children. However, there is no trial to evaluate the dose-finding of safety and efficacy of dexmedetomidine-remifentanil (DEX-RF) in children undergoing flexible bronchoscopy...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28293045/a-narrative-review-of-influenza-a-seasonal-and-pandemic-disease
#9
REVIEW
Mohsen Moghadami
Influenza is an acute respiratory disease caused by the influenza A or B virus. It often occurs in outbreaks and epidemics worldwide, mainly during the winter season. Significant numbers of influenza virus particles are present in the respiratory secretions of infected persons, so infection can be transmitted by sneezing and coughing via large particle droplets. The mean duration of influenza virus shedding in immunocompetent adult patients is around 5 days but may continue for up to 10 days or more-particularly in children, elderly adults, patients with chronic illnesses, and immunocompromised hosts...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28289448/when-is-cough-functional-and-how-should-it-be-treated
#10
REVIEW
Miles Weinberger, Boris Lockshin
KEY POINTS: Habit cough is most commonly characterised by a repetitive loud barking cough that persists for prolonged periods.The cough interferes with normal activity and substantially decreases the quality of life.The sine qua non is the total absence of this troublesome cough once asleep.The age distribution ranges from 4 years to late adolescence, with 85% of cases occurring from 8 to 14 years of age; similar cough in adults is much less common and poorly characterised.Pharmacological treatment is ineffective...
March 2017: Breathe
https://www.readbyqxmd.com/read/28289114/parents-expectations-and-experiences-of-antibiotics-for-acute-respiratory-infections-in-primary-care
#11
Peter D Coxeter, Chris Del Mar, Tammy C Hoffmann
PURPOSE: Primary care visits for children with acute respiratory infections frequently result in antibiotic prescriptions, although antibiotics have limited benefits for common acute respiratory infections and can cause harms, including antibiotic resistance. Parental demands are often blamed for antibiotic prescription. We aimed to explore parents' beliefs about antibiotic necessity, quantify their expectations of antibiotic benefit, and report experiences of other management options and exposure to and preferences for shared decision making...
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28284980/the-kingston-allergy-birth-cohort-exploring-parentally-reported-respiratory-outcomes-through-the-lens-of-the-exposome
#12
Michelle L North, Jeffrey R Brook, Elizabeth Y Lee, Vanessa Omana, Nadia M Daniel, Lisa M Steacy, Greg J Evans, Miriam L Diamond, Anne K Ellis
BACKGROUND: The Kingston Allergy Birth Cohort (KABC) is a prenatally recruited cohort initiated to study the developmental origins of allergic disease. Kingston General Hospital was chosen for recruitment because it serves a population with notable diversity in environmental exposures relevant to the emerging concept of the exposome. OBJECTIVES: To establish a profile of the KABC using the exposome framework and examine parentally reported respiratory symptoms to 2 years of age...
March 8, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28270741/sensitization-to-secretoglobin-and-lipocalins-in-a-group-of-young-children-with-risk-of-developing-respiratory-allergy
#13
Mizuho Nagao, Magnus P Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel, Takao Fujisawa
BACKGROUND: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development. METHODS: Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28264080/effect-of-an-integrated-pest-management-intervention-on-asthma-symptoms-among-mouse-sensitized-children-and-adolescents-with-asthma-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Elizabeth C Matsui, Matthew Perzanowski, Roger D Peng, Robert A Wise, Susan Balcer-Whaley, Michelle Newman, Amparito Cunningham, Adnan Divjan, Mary E Bollinger, Shuyan Zhai, Ginger Chew, Rachel L Miller, Wanda Phipatanakul
Importance: Professionally delivered integrated pest management (IPM) interventions can reduce home mouse allergen concentrations, but whether they reduce asthma morbidity among mouse-sensitized and exposed children and adolescents is unknown. Objective: To determine the effect of an IPM intervention on asthma morbidity among mouse-sensitized and exposed children and adolescents with asthma. Design, Setting, and Participants: Randomized clinical trial conducted in Baltimore, Maryland, and Boston, Massachusetts...
March 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28262319/initiation-of-an-inhaled-corticosteroid-during-a-pediatric-emergency-visit-for-asthma-a%C3%A2-randomized-clinical-trial
#15
Esther M Sampayo, Maryann Mazer-Amirshahi, Elizabeth A Camp, Joseph J Zorc
STUDY OBJECTIVE: We determine whether prescribing an inhaled corticosteroid during a pediatric emergency department (ED) asthma visit increases ongoing use and improves outcomes. METHODS: This randomized trial enrolled children aged 1 to 18 years, with persistent asthma not previously prescribed a controller medication, and who were being discharged after ED asthma treatment. Intervention subjects received a 1-month prescription for an inhaled corticosteroid (fluticasone or budesonide by age) in addition to standard asthma therapy and instructions given to all patients...
February 24, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28262075/minimising-wheeze-in-the-under-threes-developing-a-respiratory-assessment-clinic-for-children
#16
Elizabeth Jane Wood
A reluctance to diagnose asthma in children under three who have recurrent cough and wheeze causes delays in the commencement of appropriate asthma treatment. Timely inhaled corticosteroid use may reduce asthma exacerbations and unnecessary visits to the emergency department and GPs. To address this delay, an advanced nurse practitioner in one children's community nursing team set up a respiratory assessment clinic for children under three who had recurrent respiratory difficulties. This article describes the rationale and the evidence base that supports a clinic of this kind and reports on its initial results...
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28259853/effectiveness-of-a-cough-management-algorithm-at-the-transitional-phase-from-acute-to-chronic-cough-in-australian-children-aged-15%C3%A2-years-protocol-for-a-randomised-controlled-trial
#17
Kerry-Ann F O'Grady, Keith Grimwood, Maree Toombs, Theo P Sloots, Michael Otim, David Whiley, Jennie Anderson, Sheree Rablin, Paul J Torzillo, Helen Buntain, Anne Connor, Don Adsett, Oon Meng Kar, Anne B Chang
INTRODUCTION: Acute respiratory infections (ARIs) are leading causes of hospitalisation in Australian children and, if recurrent, are associated with increased risk of chronic pulmonary disorders later in life. Chronic (>4 weeks) cough in children following ARI is associated with decreased quality-of-life scores and increased health and societal economic costs. We will determine whether a validated evidence-based cough algorithm, initiated when chronic cough is first diagnosed after presentation with ARI, improves clinical outcomes in children compared with usual care...
March 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28258928/inhaled-dry-powder-mannitol-in-children-with-cystic-fibrosis-a-randomised-efficacy-and-safety-trial
#18
K De Boeck, E Haarman, J Hull, L C Lands, A Moeller, A Munck, J Riethmüller, H Tiddens, S Volpi, J Leadbetter, B Charlton, A Malfroot
INTRODUCTION: Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This trial examined the efficacy of inhaled mannitol in children with cystic fibrosis (CF). METHODS: The efficacy of inhaled mannitol in children with CF aged 6-17years was assessed in a phase 2, randomised, placebo-controlled crossover study. Subjects were randomly assigned to mannitol 400mg every 12h or matching placebo for 8weeks, followed by an 8week washout and an 8week period with the alternate treatment...
February 28, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28250606/successful-removal-of-foreign-body-bronchus-using-c-arm-guided-insertion-of-fogarty-catheter-through-plastic-bead
#19
Ravindra Ganuji Wankhede, Gaurab Maitra, Subhabrata Pal, Anirban Ghoshal, Soumen Mitra
Foreign body aspiration is still a cause of significant morbidity in children. Complications occur due to difficulty in diagnosis and treatment. An eight-year-old child presented with a history of recurrent cough for 3 days. Rigid bronchoscopy under general anesthesia revealed plastic bead occupying right main bronchus. Removal with grasping forceps failed for several times due to spherical, smooth, and large bead. Finally, Fogarty catheter was passed through bead under C-arm guidance and successfully removed...
February 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28249822/ethnobotanical-survey-of-herbal-tea-plants-from-the-traditional-markets-in-chaoshan-china
#20
Dong-Lin Li, Xi-Long Zheng, Lei Duan, Shuang-Wen Deng, Wen Ye, Ai-Hua Wang, Fu-Wu Xing
ETHNOPHARMACOLOGICAL RELEVANCE: Herbal tea, which refers to "cooling tea", "cool beverage", or "liáng chá" in China, includes a range of drinks with heat-clearing and detoxification qualities. Herbal tea plants are great contributive to the health and prosperity of Chaoshan people. The aim of the study was to document herbal tea plant species used and commercialized as "liáng chá" in Chaoshan area, to facilitate the use and development of herbal tea enterprises, and to promote the further development of national herbal tea...
February 26, 2017: Journal of Ethnopharmacology
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