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https://www.readbyqxmd.com/read/29115915/neuromodulation-in-multiple-sclerosis
#1
Hesham Abboud, Eddie Hill, Junaid Siddiqui, Alessandro Serra, Benjamin Walter
Neuromodulation, or the utilization of advanced technology for targeted electrical or chemical neuronal stimulation or inhibition, has been expanding in several neurological subspecialties. In the past decades, immune-modulating therapy has been the main focus of multiple sclerosis (MS) research with little attention to neuromodulation. However, with the recent advances in disease-modifying therapies, it is time to shift the focus of MS research to neuromodulation and restoration of function as with other neurological subspecialties...
November 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29100969/imipramine-for-refractory-daytime-incontinence-in-the-pediatric-population
#2
Israel Franco, Angela M Arlen, Therese Collett-Gardere, Paul F Zelkovic
INTRODUCTION AND OBJECTIVE: Lower urinary tract (LUT) and voiding dysfunction constitute a large percentage of pediatric urology referrals. Children with urinary incontinence unresponsive to behavioral modifications and traditional pharmacotherapy including anticholinergics and alpha blockers remain a challenge. We evaluated the impact of imipramine on treatment outcomes in children with refractory incontinence. STUDY DESIGN: Children ≤18 years of age with refractory non-neurogenic daytime incontinence prescribed imipramine were identified...
October 9, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29070575/saphenous-nerve-stimulation-normalizes-bladder-underactivity-induced-by-tibial-nerve-stimulation-in-cats
#3
Shun Li, Xing Li, Katherine Theisen, Jeffrey Browning, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
This study in α-chloralose anesthetized cats aimed at investigating the bladder responses to saphenous nerve stimulation (SNS). A urethral catheter was used to infuse the bladder with saline and to record changes in bladder pressure. With the bladder fully distended, SNS at 1 Hz frequency and an intensity slightly below the threshold (T) for inducing an observable motor response of the hindlimb muscles induced large amplitude (40-150 cmH2O) bladder contractions. Application of SNS (1 Hz, 2-4T) during cystometrograms (CMGs), when the bladder was slowly (1-3 ml/min) infused with saline, significantly (p<0...
October 25, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29064651/effectiveness-and-durability-of-solifenacin-versus-percutaneous-tibial-nerve-stimulation-versus-their-combination-for-the-treatment-of-women-with-overactive-bladder-syndrome-a-randomized-controlled-study-with-a-follow-up-of-ten-months
#4
Carlo Vecchioli-Scaldazza, Carolina Morosetti
PURPOSE: To assess effectiveness and durability of Solifenacin (SS) versus tibial nerve stimulation (PTNS) versus combination therapy (PTNS + SS) in women with overactive bladder syndrome (OAB). MATERIALS AND METHODS: 105 women with OAB were divided randomly into three groups of 35 patients each. In group A women received SS, in group B women underwent PTNS, in group C women underwent combination of PTNS + SS. Improvements in OAB symptoms were assessed with OABSS questionnaire; patients' quality of life was assessed with OAB-q SF questionnaire...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29063170/-neuromodulation-of-lower-urinary-tract-dysfunction
#5
REVIEW
T M Kessler, S de Wachter
Neuromodulative procedures such as transcutaneous electrical nerve stimulation (TENS), transcutaneous/percutaneous tibial nerve stimulation (TTNS/PTNS), and sacral neuromodulation (SNM) are promising second-line treatments for refractory lower urinary tract dysfunction. Using these therapies, both storage and voiding disorders but also bowel dysfunction might be successfully treated. Although the mechanism of action of neuromodulation is not well understood, it seems to involve modulation of spinal cord reflexes and brain networks by peripheral afferents (genital/rectal, tibial and sacral afferents in the case of TENS, TTNS/PTNS, and SNM, respectively)...
October 23, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29046985/new-devices-and-technologies-for-the-management-of-overactive-bladder
#6
REVIEW
Juan M Guzman-Negron, Howard B Goldman
PURPOSE OF REVIEW: Overactive bladder (OAB) affects millions of people in the USA and has a significant impact on their quality of life. Despite having a number of safe and effective ways of managing refractory OAB patients, there are many promising new technologies actively being studied and developed for the treatment of this population. This review examines current new devices and technologies under study for the treatment of OAB. RECENT FINDINGS: Modifications to already established therapies such as sacral nerve stimulation (SNS) or tibial nerve stimulation (TNS) are currently being studied for refractory OAB...
October 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29022807/surgery-for-popliteal-artery-entrapment-syndrome-use-of-an-intraoperative-tibial-nerve-stimulator-and-duplex-ultrasound
#7
G Dovell, R J Hinchliffe
No abstract text is available yet for this article.
September 13, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28964687/-outcomes-of-transcutaneous-posterior-tibial-nerve-stimulation-for-overactive-bladder-in-diabetic-patients
#8
L Mathieu, B Peyronnet, N Senal, S Fontaine, A Manunta, T Honoré, J Hascoet, M Damphousse, I Bonan, J Kerdraon
OBJECTIVE: Treatment with transcutaneous posterior tibial neurostimulation (NTPT) has been shown to be effective in the treatment of overactive bladder (OAB), but its outcomes in diabetic patients have never been assessed. The aim of this study was to compare the efficacy of NTPT in diabetic OAB patients and in OAB patients without diabetes. METHODS: A single-center prospective study included all patients treated with NTPT for lower urinary tract storage symptoms between 2012 and 2016...
September 27, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28918684/differential-induction-of-c-fos-and-phosphorylated-erk-by-a-noxious-stimulus-after-peripheral-nerve-injury
#9
Mitsuyasu Tabata, Ryuji Terayama, Kotaro Maruhama, Seiji Iida, Tomosada Sugimoto
PURPOSE: In this study, we compared induction of c-Fos and phosphorylated extracellular signal-regulated kinase (p-ERK) in the spinal dorsal horn after peripheral nerve injury. MATERIALS AND METHODS: We examined the spinal dorsal horn for noxious heat-induced c-Fos and p-ERK protein-like immunoreactive (c-Fos- and p-ERK-IR) neuron profiles after tibial nerve injury. The effect of administration of a MEK 1/2 inhibitor (PD98059) on noxious heat-induced c-Fos expression was also examined after tibial nerve injury...
October 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28892581/direct-current-stimulation-modulates-the-excitability-of-the-sensory-and-motor-fibres-in-the-human-posterior-tibial-nerve-with-a-long-lasting-effect-on-the-h-reflex
#10
Francesco Bolzoni, Roberto Esposti, Carlo Bruttini, Giuseppe Zenoni, Elzbieta Jankowska, Paolo Cavallari
Several studies demonstrated that transcutaneous direct current stimulation (DCS) may modulate central nervous system excitability. However, much less is known about how DC affects peripheral nerve fibres. We investigated the action of DCS on motor and sensory fibres of the human posterior tibial nerve, with supplementary analysis in acute experiments on rats. In forty human subjects, electric pulses at the popliteal fossa were used to elicit either M-waves or H-reflexes in the Soleus, before (15 min), during (10 min) and after (30 min) DCS...
September 11, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28892221/a-novel-leadless-miniature-implantable-tibial-nerve-neuromodulation-system-for-the-management-of-overactive-bladder-complaints
#11
John P F A Heesakkers, Guiseppe A Digesu, Jetske van Breda, Philip Van Kerrebroeck, Sohier Elneil
BACKGROUND: Overactive bladder is a chronic condition affecting lower urinary tract function that has a significant negative impact on QoL. OBJECTIVE: Evaluation of the BlueWind implantable tibial nerve system performance and safety in refractory OAB. DESIGN, SETTING, AND PARTICIPANTS INTERVENTION: A 6-month multi-center prospective intervention study. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Objective assessment was done by voiding diary parameters included voids/day, volume voided/day, urgency assessment, leaking episodes/day, pads used/day, leak severity, and clinical success defined as a ≥50% reduction in the number of leaks/day or number of voids/day or number of episodes with degree of urgency >2 or a return to <8 voids/day on a 3 Day diary...
September 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28870837/post-tetanic-transcranial-motor-evoked-potentials-augment-the-amplitude-of-compound-muscle-action-potentials-recorded-from-innervated-and-non-innervated-muscles
#12
Hideki Shigematsu, Masahiko Kawaguchi, Hironobu Hayashi, Tsunenori Takatani, Eiichiro Iwata, Masato Tanaka, Akinori Okuda, Yasuhiko Morimoto, Keisuke Masuda, Yusuke Yamamoto, Yasuhito Tanaka
BACKGROUND CONTEXT: Transcranial electrical stimulation used to produce motor evoked potentials (TES-MEPs) and subsequent compound muscle action potential (CMAP) recording is widely used to monitor motor function during surgery when there is risk of damaging the spinal cord. Nonetheless, some muscles do not produce CMAP amplitudes sufficient for intraoperative monitoring. PURPOSE: This study aimed to investigate the utility of tetanic stimulation at single and multiple peripheral nerve sites for augmenting CMAP amplitudes recorded from innervated and non-innervated muscles...
September 1, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28861404/effectiveness-of-percutaneous-tibial-nerve-stimulation-in-the-treatment-of-overactive-bladder-syndrome
#13
REVIEW
Liesbeth L de Wall, John Pfa Heesakkers
Overactive bladder syndrome (OAB) is a common condition affecting adults and children worldwide, resulting in a substantial economic and psychological burden. Percutaneous tibial nerve stimulation (PTNS) is derived from acupuncture used in Chinese traditional medicine and was first described in the early 1980s. It is a neuromodulation technique used to modulate bladder function and facilitate storage. Being a minimally invasive, easily applicable, but time-consuming treatment, future developments with implantable devices might be the solution for the logistical problems and economic burden associated with PTNS on the long term...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28855188/an-excitatory-reflex-from-the-superficial-peroneal-nerve-to-the-bladder-in-cats
#14
Michelle Yu, Jamie Uy, Xuewen Jiang, Xing Li, Cameron Jones, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
This study in α-chloralose anesthetized cats discovered an excitatory peroneal nerve-to-bladder reflex. A urethral catheter was used to infuse the bladder with saline and record bladder pressure changes. Electrical stimulation was applied to the superficial peroneal nerve to trigger a reflex bladder activity. With the bladder distended at a volume about 90% of bladder capacity, superficial peroneal nerve stimulation (PNS) at 1-3 Hz and threshold (T) intensity for inducing muscle twitching on the posterior thigh induced large amplitude (40-150 cmH2O) bladder contractions...
August 30, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28838787/surgical-interventions-and-the-use-of-device-aided-therapy-for-the-treatment-of-fecal-incontinence-and-defecatory-disorders
#15
Adil E Bharucha, Satish S C Rao, Andrea Shin
The purpose of this clinical practice update expert review is to describe the key principles in the use of surgical interventions and device-aided therapy for managing fecal incontinence (FI) and defecatory disorders. The best practices outlined in this review are based on relevant publications, including systematic reviews and expert opinion (when applicable). Best Practice Advice 1: A stepwise approach should be followed for management of FI. Conservative therapies (diet, fluids, techniques to improve evacuation, a bowel training program, management of diarrhea and constipation with diet and medications if necessary) will benefit approximately 25% of patients and should be tried first...
August 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28803174/intraoperative-vascular-neuromonitoring-in-patients-with-subarachnoid-hemorrhage-a%C3%A2-pilot-study-using-combined-laser-doppler-spectrophotometry
#16
Emilija Schmitz, Barbara Bischoff, Dennis Wolf, Hubert J Schmitt, Ilker Y Eyupoglu, Karl Roessler, Michael Buchfelder, Björn Sommer
BACKGROUND: Intraoperative monitoring of cerebral microcirculation in patients with subarachnoid hemorrhage (SAH) may predict the postoperative neurologic outcome. In this pilot study, we examined the value of a novel noninvasive real-time measurement technique for detecting changes in local microcirculation. METHODS: We used the O2C (Oxygen to see) laser-Doppler spectrophotometry system in 14 patients with Hunt & Hess grade 2-5 SAH who underwent microsurgical cerebral aneurysm clipping...
November 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28792105/transcutaneous-posterior-tibial-nerve-electrostimulation-with-low-dose-trospium-chloride-could-it-be-used-as-a-second-line-treatment-of-overactive-bladder-in-females
#17
Amr Abulseoud, Ahmed Moussa, Gaber Abdelfattah, Ibrahim Ibrahim, Emmanuel Saba, Mohamed Hassouna
AIM: To evaluate the effect of adding low dose trospium chloride with transcutaneous posterior tibial nerve stimulation (TPTNS) in the treatment of overactive bladder (OAB) in females after failure of behavioral therapy. METHODS: We randomized 30 women with OAB, in two groups: G I received 30 min TPTNS, three times a week; GII received TPTNS plus 20 mg trospium chloride daily. OAB Symptom Score questionnaire (OABSS), Incontinence Impact Questionnaire-short form 7 (IIQ-7), 3 day voiding diary and urodynamics at weeks 0 and 8 were evaluated...
August 9, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28744060/effects-of-physiotherapy-treatment-for-urinary-incontinence-in-patient-with-multiple-sclerosis
#18
Carla Maria de Abreu Pereira, Mariane Castiglione, Karina Tamy Kasawara
[Purpose] The aim of the study was to evaluate the benefits of physical therapy for urinary incontinence in patients with multiple sclerosis and to verify the impact of urinary incontinence on the patient's quality of life. [Subject and Methods] A case study of a 55-year-old female patient diagnosed with multiple sclerosis and mixed urinary incontinence was conducted. Physical therapy sessions were conducted once a week, in total 15 sessions, making use of targeted functional electrical vaginal stimulation, along with active exercises for the pelvic floor muscles and electrical stimulation of the posterior tibial nerve, behavioral rehabilitation and exercise at home...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28731583/the-effectiveness-of-transcutaneous-tibial-nerve-stimulation-ttns-for-adults-with-overactive-bladder-syndrome-a-systematic-review
#19
REVIEW
Joanne Booth, Lesley Connelly, Sylvia Dickson, Fiona Duncan, Maggie Lawrence
AIMS: To evaluate effectiveness of transcutaneous tibial nerve stimulation (TTNS) for treating adults with overactive bladder (OAB) of idiopathic or neurogenic origin, using a systematic review of the literature. METHODS: Systematic searches of four databases were undertaken between 1980 and 2017. Included studies investigated effects of TTNS on OAB. Study selection, data extraction, quality appraisal was performed by two independent reviewers. Narrative analysis was undertaken where meta-analysis was not possible due to study heterogeneity...
July 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28724780/a-reduced-somatosensory-gating-response-in-individuals-with-multiple-sclerosis-is-related-to-walking-impairment
#20
David J Arpin, James E Gehringer, Tony W Wilson, Max J Kurz
When identical stimuli are presented in rapid temporal succession, neural responses to the second stimulation are often weaker than those observed for the first. This phenomenon is termed sensory gating and is believed to be an adaptive feature that helps prevent higher-order cortical centers from being flooded with unnecessary information. Recently, sensory gating in the somatosensory system has been linked to deficits in tactile discrimination. Additionally, studies have linked poor tactile discrimination with impaired walking and balance in individuals with multiple sclerosis (MS)...
October 1, 2017: Journal of Neurophysiology
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