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https://www.readbyqxmd.com/read/28109158/using-the-volta-phase-plate-with-defocus-for-cryo-em-single-particle-analysis
#1
Radostin Danev, Dimitry Tegunov, Wolfgang Baumeister
Previously, we reported an in-focus data acquisition method for cryo-EM single particle analysis with the Volta phase plate (VPP) (Danev and Baumeister, 2016). Here, we extend the technique to include a small amount of defocus which enables contrast transfer function measurement and correction. This hybrid approach simplifies the experiment and increases the data acquisition speed. It also removes the resolution limit inherent to the in-focus method thus allowing 3D reconstructions with resolutions better than 3 Å...
January 21, 2017: ELife
https://www.readbyqxmd.com/read/28109120/real-time-3-dimensional-echocardiographic-assessment-of-effective-regurgitant-orifice-area-in-dogs-with-myxomatous-mitral-valve-disease
#2
A Tidholm, A Bodegård-Westling, K Höglund, J Häggström, I Ljungvall
BACKGROUND: Effective regurgitant orifice area (EROA), calculated from the vena contracta width (VCW) as the narrowest portion of the proximal regurgitant jet, might be used to estimate severity of mitral regurgitation. However, this simplified assumption only holds when the EROA is circular, which might not be true in dogs with myxomatous mitral valve disease (MMVD). HYPOTHESIS: Effective regurgitant orifice area in dogs with MMVD is noncircular, and using color Doppler real-time 3-dimensional (RT3D) echocardiography, measured EROA in the en face view will be significantly different from calculated EROA...
January 21, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28109097/-mucosal-healing-in-different-intestinal-segments-in-patients-receiving-infliximab-treatment-for-small-bowel-crohn-s-disease
#3
Zhen-Hao Zhu, Chen Qiu, Ming Zhang, Zhao Chen, Cheng Xiang, Xin-Ying Wang
OBJECTIVE: To evaluate the mucosal healing in the terminal ileum, colon and small bowel in patients receiving infliximab treatment for small bowel Crohn's disease (SBCD). METHODS: The clinical data of 18 patients with SBCD treated with infliximab were analyzed for laboratory findings (routine blood tests, C-reative protein, and albumin), Crohn's disease activity index (CDAI), Lewis score (LS), Crohn's disease simplified endoscopic score (SES-CD) and adverse effects before and after 30 weeks of infliximab treatment...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28108657/risearch2-suffix-array-based-large-scale-prediction-of-rna-rna-interactions-and-sirna-off-targets
#4
Ferhat Alkan, Anne Wenzel, Oana Palasca, Peter Kerpedjiev, Anders Frost Rudebeck, Peter F Stadler, Ivo L Hofacker, Jan Gorodkin
Intermolecular interactions of ncRNAs are at the core of gene regulation events, and identifying the full map of these interactions bears crucial importance for ncRNA functional studies. It is known that RNA-RNA interactions are built up by complementary base pairings between interacting RNAs and high level of complementarity between two RNA sequences is a powerful predictor of such interactions. Here, we present RIsearch2, a large-scale RNA-RNA interaction prediction tool that enables quick localization of potential near-complementary RNA-RNA interactions between given query and target sequences...
January 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28108565/frozen-versus-conventional-elephant-trunk-technique-application-in-clinical-practice
#5
REVIEW
Roberto Di Bartolomeo, Giacomo Murana, Luca Di Marco, Antonio Pantaleo, Jacopo Alfonsi, Alessandro Leone, Davide Pacini
SummaryTreating complex aortic arch disease with proximal and distal aortic segment involvement is challenging. In recent years, different surgical and endovascular techniques have been applied in a single or multiple-stage approach with the aim to cure and simplify these conditions. The first procedure available for this purpose was the conventional elephant trunk technique. Its recent evolution is the frozen elephant trunk, which treats the descending thoracic aorta using the antegrade release of a self-expandable stent graft...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28108115/a-reappraisal-of-the-surgical-planning-of-the-superficial-circumflex-iliac-artery-perforator-flap
#6
Shaoqing Feng, Wenjing Xi, Zheng Zhang, Mathias Tremp, Dirk J Schaefer, Parviz L Sadigh, Wenjie Zhang, Yi Xin Zhang
OBJECTIVE: The popularity of the superficial circumflex iliac artery perforator (SCIP) flap has been limited by factors such as variable vascular anatomy and short arterial pedicle. This article aimed to delineate flap design and harvest strategies based around either the proximal or distal perforators of the superficial circumflex iliac artery (SCIA) and propose a set of strategies that can help deal with the limitations of the flap. METHOD: From August 2011 to June 2015, the SCIP flap was used in 80 patients for soft tissue defects at our institution...
December 22, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28108022/evaluation-of-a-method-for-removing-cesium-and-reducing-the-volume-of-leaf-litter-from-broad-leaved-trees-contaminated-by-the-fukushima-daiichi-nuclear-accident-during-the-great-east-japan-earthquake
#7
Shigeki Harada, Mitsunori Yanagisawa
The town of Marumori in southern Miyagi Prefecture borders on Fukushima Prefecture, and following the accident at the Fukushima Daiichi nuclear power plant, there were concerns about cesium deposition in forested areas. One of the authors of this paper has continually surveyed leaf litter from the forested areas. As leaf litter may be a source of cesium contamination from the forest to downstream areas, we considered a simplified version of wet oxidation, a method previously presented by one of the authors of this study, as a technology to reduce leaf litter weight and cesium concentration, separating radioactive nuclides from non-radioactive ones, in leaf litter...
January 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28108002/reduced-order-model-based-active-disturbance-rejection-control-of-hydraulic-servo-system-with-singular-value-perturbation-theory
#8
Chengwen Wang, Long Quan, Shijie Zhang, Hongjun Meng, Yuan Lan
Hydraulic servomechanism is the typical mechanical/hydraulic double-dynamics coupling system with the high stiffness control and mismatched uncertainties input problems, which hinder direct applications of many advanced control approaches in the hydraulic servo fields. In this paper, by introducing the singular value perturbation theory, the original double-dynamics coupling model of the hydraulic servomechanism was reduced to a integral chain system. So that, the popular ADRC (active disturbance rejection control) technology could be directly applied to the reduced system...
January 17, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28106767/development-and-evaluation-of-e-ca-an-electronic-mobile-based-food-record
#9
Sophie Bucher Della Torre, Isabelle Carrard, Eddy Farina, Brigitta Danuser, Maaike Kruseman
Measures that capture diet as validly and reliably as possible are cornerstones of nutritional research, and mobile-based devices offer new opportunities to improve and simplify data collection. The balance between precision and acceptability of these data collection tools remains debated, and rigorous validations are warranted. Our objective was to develop and evaluate an electronic mobile-based food record for a research setting. We developed e-CA, which includes almost 900 foods and beverages classified in 14 categories and 60 subcategories...
January 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28106764/effective-alternating-direction-optimization-methods-for-sparsity-constrained-blind-image-deblurring
#10
Naixue Xiong, Ryan Wen Liu, Maohan Liang, Di Wu, Zhao Liu, Huisi Wu
Single-image blind deblurring for imaging sensors in the Internet of Things (IoT) is a challenging ill-conditioned inverse problem, which requires regularization techniques to stabilize the image restoration process. The purpose is to recover the underlying blur kernel and latent sharp image from only one blurred image. Under many degraded imaging conditions, the blur kernel could be considered not only spatially sparse, but also piecewise smooth with the support of a continuous curve. By taking advantage of the hybrid sparse properties of the blur kernel, a hybrid regularization method is proposed in this paper to robustly and accurately estimate the blur kernel...
January 18, 2017: Sensors
https://www.readbyqxmd.com/read/28106746/fisheye-based-method-for-gps-localization-improvement-in-unknown-semi-obstructed-areas
#11
Julien Moreau, Sébastien Ambellouis, Yassine Ruichek
A precise GNSS (Global Navigation Satellite System) localization is vital for autonomous road vehicles, especially in cluttered or urban environments where satellites are occluded, preventing accurate positioning. We propose to fuse GPS (Global Positioning System) data with fisheye stereovision to face this problem independently to additional data, possibly outdated, unavailable, and needing correlation with reality. Our stereoscope is sky-facing with 360° × 180° fisheye cameras to observe surrounding obstacles...
January 17, 2017: Sensors
https://www.readbyqxmd.com/read/28106360/federal-policy-for-the-protection-of-human-subjects-final-rule
#12
(no author information available yet)
The departments and agencies listed in this document announce revisions to modernize, strengthen, and make more effective the Federal Policy for the Protection of Human Subjects that was originally promulgated as a Common Rule in 1991. This final rule is intended to better protect human subjects involved in research, while facilitating valuable research and reducing burden, delay, and ambiguity for investigators. These revisions are an effort to modernize, simplify, and enhance the current system of oversight...
19, 2017: Federal Register
https://www.readbyqxmd.com/read/28106338/the-original-and-simplified-wells-rules-and-age-adjusted-d-dimer-testing-to-rule-out-pulmonary-embolism-an-individual-patient-data-meta-analysis
#13
Nick van Es, Noémie Kraaijpoel, Frederikus A Klok, Menno V Huisman, Paul L Den Exter, Inge C M Mos, Javier Galipienzo, Harry R Büller, Patrick M Bossuyt
BACKGROUND: The Wells score and D-dimer testing can safely rule out pulmonary embolism (PE). A simplification of the Wells score has been proposed to improve clinical applicability, but evidence on its performance is scarce. OBJECTIVES: To compare the performance of the original and simplified Wells scores alone and in combination with age-adjusted D-dimer testing. METHODS: Individual patient data from 7,268 patients with suspected PE enrolled in 6 management studies were used to evaluate the discriminatory performance of the original and simplified Wells scores...
January 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28106105/autoimmune-hepatitis-review-of-histologic-features-included-in-the-simplified-criteria-proposed-by-the-international-autoimmune-hepatitis-group-and-proposal-for-new-histologic-criteria
#14
Dana Balitzer, Nafis Shafizadeh, Marion G Peters, Linda D Ferrell, Najeeb Alshak, Sanjay Kakar
Simplified criteria for diagnosis of autoimmune hepatitis are based on autoantibodies, serum immunoglobulin G, histologic features, and negative viral serology. A score of 6 points is necessary for the designation of probable autoimmune hepatitis and 7 points or more for definite autoimmune hepatitis. The presence of three histologic features is required for categorizing a case as typical (2 points): interface hepatitis with portal lymphocytic/lymphoplasmacytic cells extending into lobule, emperipolesis, and rosettes...
January 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28105946/a-physarum-inspired-prize-collecting-steiner-tree-approach-to-identify-subnetworks-for-drug-repositioning
#15
Yahui Sun, Pathima Nusrath Hameed, Karin Verspoor, Saman Halgamuge
BACKGROUND: Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition drugs as pharmacological data is large and complex. Subnetwork identification has already been used to simplify the visualization and interpretation of biological data, but it has not been applied to drug repositioning so far. In this paper, we fill this gap by proposing a new Physarum-inspired Prize-Collecting Steiner Tree algorithm to identify subnetworks for drug repositioning...
December 5, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28105848/simplifying-nanowire-hall-effect-characterization-by-using-a-three-probe-device-design
#16
Olof Hultin, Gaute Otnes, Lars Samuelson, Kristian Storm
Electrical characterization of nanowires is a time-consuming and challenging task due to the complexity of single nanowire device fabrication and the difficulty in interpreting the measurements. We present a method to measure Hall effect in nanowires using a three-probe device that is simpler to fabricate than previous four-probe nanowire Hall devices and allows characterization of nanowires with smaller diameter. Extraction of charge carrier concentration from the three-probe measurements using an analytical model is discussed and compared to simulations...
January 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28105550/stable-isotope-labeling-for-improved-comparative-analysis-of-rna-digests-by-mass-spectrometry
#17
Mellie June Paulines, Patrick A Limbach
Even with the advent of high throughput methods to detect modified ribonucleic acids (RNAs), mass spectrometry remains a reliable method to detect, characterize, and place post-transcriptional modifications within an RNA sequence. Here we have developed a stable isotope labeling comparative analysis of RNA digests (SIL-CARD) approach, which improves upon the original (18)O/(16)O labeling CARD method. Like the original, SIL-CARD allows sequence or modification information from a previously uncharacterized in vivo RNA sample to be obtained by direct comparison with a reference RNA, the sequence of which is known...
January 19, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28105259/clinical-usefulness-of-ursodeoxycholic-acid-for-japanese-patients-with-autoimmune-hepatitis
#18
Yuichi Torisu, Masanori Nakano, Keiko Takano, Ryo Nakagawa, Chisato Saeki, Atsushi Hokari, Tomohisa Ishikawa, Masayuki Saruta, Mikio Zeniya
AIM: To evaluate the therapeutic effects of ursodeoxycholic acid (UDCA) on autoimmune hepatitis (AIH). METHODS: A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy (Group U, n = 48) and prednisolone (PSL) monotherapy (Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse (Subgroup U1, n = 34) and patients who additionally received PSL during follow-up (Subgroup U2, n = 14)...
January 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28104197/simplified-mitral-valve-repair-in-pediatric-patients-with-connective-tissue-disorders
#19
Luca A Vricella, William A Ravekes, Eloisa Arbustini, Robert D B Jaquiss, Constantine Mavroudis, Harry C Dietz, Marshall L Jacobs, Narutoshi Hibino, Duke E Cameron
BACKGROUND: In pediatric patients with connective tissue disorders (CTDs), early cardiac presentation often involves severe mitral regurgitation (MR) associated with severe bileaflet prolapse and, less frequently, aortic root enlargement. We adopted a simplified repair to address MR and prevent systolic anterior motion (SAM) in this unique group of patients. MATERIALS AND METHODS: Retrospective review of clinical and echocardiographic data of all pediatric patients (age < 18 years) with CTD and MR undergoing simplified repair at 3 institutions (2000-2014)...
February 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28103680/targeting-nf-%C3%AE%C2%BAb-p65-with-a-helenalin-inspired-bis-electrophile
#20
John C Widen, Aaron M Kempema, Peter W Villalta, Daniel A Harki
The canonical NF-κB signaling pathway is a mediator of the cellular inflammatory response and a target for developing therapeutics for multiple human diseases. The furthest downstream proteins in the pathway, the p50/p65 transcription factor heterodimer, have been recalcitrant toward small molecule inhibition despite the substantial number of compounds known to inhibit upstream proteins in the activation pathway. Given the roles of many of these upstream proteins in multiple biochemical pathways, targeting the p50/p65 heterodimer offers an opportunity for enhanced on-target specificity...
January 20, 2017: ACS Chemical Biology
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