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https://www.readbyqxmd.com/read/29616079/-stat6-pbx2-and-pbrm1-emerge-as-predicted-regulators-of-452-differentially-expressed-genes-associated-with-puberty-in-brahman-heifers
#1
Loan T Nguyen, Antonio Reverter, Angela Cánovas, Bronwyn Venus, Stephen T Anderson, Alma Islas-Trejo, Marina M Dias, Natalie F Crawford, Sigrid A Lehnert, Juan F Medrano, Milt G Thomas, Stephen S Moore, Marina R S Fortes
The liver plays a central role in metabolism and produces important hormones. Hepatic estrogen receptors and the release of insulin-like growth factor 1 (IGF1) are critical links between liver function and the reproductive system. However, the role of liver in pubertal development is not fully understood. To explore this question, we applied transcriptomic analyses to liver samples of pre- and post-pubertal Brahman heifers and identified differentially expressed (DE) genes and genes encoding transcription factors (TFs)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29478410/psychotropic-medications-in-older-people-in-residential-care-facilities-and-associations-with-quality-of-life-a-cross-sectional-study
#2
Stephanie L Harrison, Clare Bradley, Rachel Milte, Enwu Liu, Lisa Kouladjian O'Donnell, Sarah N Hilmer, Maria Crotty
BACKGROUND: Psychotropic medications have been associated with many adverse outcomes in older people living in residential care. Home-like models of residential care may be preferable to traditional models of care and we hypothesized that this model may impact on the prevalence of psychotropic medications. The objectives were to: 1) examine associations between psychotropic medications and quality of life in older adults living in residential care facilities with a high prevalence of cognitive impairment and dementia and 2) determine if there was a difference in prevalence of psychotropic medications in facilities which provide a small group home-like model of residential care compared to a 'standard model' of care...
February 26, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29345495/milton-frank-shore-1928-2017
#3
Robert Henley Woody
Presents an obituary for Milton Frank Shore, who passed away on January 6, 2017, due to pneumonia. During a long career, he was a tireless advocate for children, particularly those who were underserved. In addition, he made important contributions as an author, editor, and administrator. He was actively engaged in independent practice at the time of his death. Milt was one of the founders of American Psychological Association (APA) Division 37 (Child, Youth, and Family Services) and served as its president (1978-1979)...
January 2018: American Psychologist
https://www.readbyqxmd.com/read/29325531/costs-of-potentially-inappropriate-medication-use-in-residential-aged-care-facilities
#4
S L Harrison, L Kouladjian O'Donnell, R Milte, S M Dyer, E S Gnanamanickam, C Bradley, E Liu, S N Hilmer, M Crotty
BACKGROUND: The potential harms of some medications may outweigh their potential benefits (inappropriate medication use). Despite recommendations to avoid the use of potentially inappropriate medications (PIMs) in older adults, the prevalence of PIM use is high in different settings including residential aged care. However, it remains unclear what the costs of these medications are in this setting. The main objective of this study was to determine the costs of PIMs in older adults living in residential care...
January 11, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29322470/associations-between-the-drug-burden-index-potentially-inappropriate-medications-and-quality-of-life-in-residential-aged-care
#5
Stephanie L Harrison, Lisa Kouladjian O'Donnell, Clare E Bradley, Rachel Milte, Suzanne M Dyer, Emmanuel S Gnanamanickam, Enwu Liu, Sarah N Hilmer, Maria Crotty
BACKGROUND: Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE: The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate medications were associated with quality of life in older adults living in residential care with a high prevalence of cognitive impairment and dementia...
January 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29314590/taste-choice-and-timing-investigating-resident-and-carer-preferences-for-meals-in-aged-care-homes
#6
Rachel Milte, Julie Ratcliffe, Gang Chen, Michelle Miller, Maria Crotty
There has been little empirical investigation of the preferences of people living in aged care homes for food services. The aim of the present study was to elicit consumer preferences and their willingness to pay for food service in aged care homes. Current residents or their family members were invited to take part in the discrete choice experiment questionnaire administered via interview. Of the 109 eligible residents and 175 eligible family members approached for consent 121 (43%) participated, including 43 residents...
March 2018: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29305782/an-empirical-comparison-of-the-measurement-properties-of-the-eq-5d-5l-demqol-u-and-demqol-proxy-u-for-older-people-in-residential-care
#7
Tiffany Easton, Rachel Milte, Maria Crotty, Julie Ratcliffe
PURPOSE: This study aimed to empirically compare the measurement properties of self-reported and proxy-reported (in cases of severe cognitive impairment) generic (EQ-5D-5L) and condition-specific (DEMQOL-U and DEMQOL-Proxy-U) preference-based HRQoL instruments in residential care, where the population is characterised by older people with high rates of cognitive impairment, dementia and disability. METHODS: Participants were recruited from seventeen residential care facilities across four Australian states...
May 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29274115/a-novel-desmin-des-indel-mutation-causes-severe-atypical-cardiomyopathy-in-combination-with-atrioventricular-block-and-skeletal-myopathy
#8
Ilona Schirmer, Mareike Dieding, Bärbel Klauke, Andreas Brodehl, Anna Gaertner-Rommel, Volker Walhorn, Jan Gummert, Uwe Schulz, Lech Paluszkiewicz, Dario Anselmetti, Hendrik Milting
BACKGROUND: DES mutations cause different cardiac and skeletal myopathies. Most of them are missense mutations. METHODS: Using a next-generation sequencing cardiac 174 gene panel, we identified a novel heterozygous in-frame indel mutation (DES-c.493_520del28insGCGT, p.Q165_A174delinsAS) in a Caucasian patient with cardiomyopathy in combination with atrioventricular block and skeletal myopathy. This indel mutation is located in the coding region of the first exon...
December 23, 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29212901/-flnc-filamin-c-a-new-er-player-in-the-field-of-genetic-cardiomyopathies
#9
EDITORIAL
Andreas Brodehl, Anna Gaertner-Rommel, Hendrik Milting
No abstract text is available yet for this article.
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29212896/the-novel-desmin-mutation-p-glu401asp-impairs-filament-formation-disrupts-cell-membrane-integrity-and-causes-severe-arrhythmogenic-left-ventricular-cardiomyopathy-dysplasia
#10
Francisco José Bermúdez-Jiménez, Víctor Carriel, Andreas Brodehl, Miguel Alaminos, Antonio Campos, Ilona Schirmer, Hendrik Milting, Beatriz Álvarez Abril, Miguel Álvarez, Silvia López-Fernández, Diego García-Giustiniani, Lorenzo Monserrat, Luis Tercedor, Juan Jiménez-Jáimez
Background -Desmin ( DES ) mutations cause severe skeletal and cardiac muscle disease with heterogeneous phenotypes. Recently, DES mutations were described in patients with inherited arrhythmogenic right ventricular cardiomyopathy/dysplasia (iARVC/D), although their cellular and molecular pathomechanisms are not precisely known. Our aim is to describe clinically and functionally the novel DES -p.Glu401Asp mutation as a cause of inherited left ventricular arrhythmogenic cardiomyopathy/dysplasia (iLVAC/D). Methods -We identified the novel DES mutation p...
December 6, 2017: Circulation
https://www.readbyqxmd.com/read/29175681/in-vitro-inoculation-of-aeromonas-hydrophila-and-pseudomonas-fluorescens-in-cryopreserved-silver-barb-barbodes-gonionotus-milt-effect-on-fertilization-capacity-and-transmission-potential-to-embryos
#11
Traimat Boonthai, Weerasith Khaopong, Jumlong Sangsong, Verapong Vuthiphandchai, Subuntith Nimrat
Purposive use of cryopreserved sperm contaminated with pathogenic agents has increased the risk of spreading of fish diseases. The objective of this study was to investigate the effects of A. hydrophila subsp. hydrophila and P. fluorescens inoculations into cryostored milt on fertilization capacity and transmission potential to embryos of silver barb (Barbodes gonionotus) with or without 0.25% penicillin-streptomycin (PS) administration. The experiment comprised six treatments: addition of milt into T1) extender only, T2) extender with 0...
March 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/29163146/influence-of-sequential-vs-simultaneous-dual-task-exercise-training-on-cognitive-function-in-older-adults
#12
REVIEW
Jamie L Tait, Rachel L Duckham, Catherine M Milte, Luana C Main, Robin M Daly
Emerging research indicates that exercise combined with cognitive training may improve cognitive function in older adults. Typically these programs have incorporated sequential training, where exercise and cognitive training are undertaken separately. However, simultaneous or dual-task training, where cognitive and/or motor training are performed simultaneously with exercise, may offer greater benefits. This review summary provides an overview of the effects of combined simultaneous vs. sequential training on cognitive function in older adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29133306/quaking-inhibits-doxorubicin-mediated-cardiotoxicity-through-regulation-of-cardiac-circular-rna-expression
#13
Shashi Kumar Gupta, Ankita Garg, Christian Bär, Shambhabi Chatterjee, Ariana Foinquinos, Hendrik Milting, Katrin Streckfuß-Bömeke, Jan Fiedler, Thomas Thum
RATIONALE: RBPs (RNA-binding proteins) have been described to be expressed and regulated in various organs including the heart. Little is known about the role of RBPs in heart failure induced by the chemotherapy drug doxorubicin and their interaction with circular RNAs. OBJECTIVE: We aimed to identify key RBPs involved in doxorubicin-mediated heart failure and to elucidate their function. METHODS AND RESULTS: Global transcriptome profiling from murine myocardium exposed to doxorubicin identified 5 differentially expressed RBPs...
January 19, 2018: Circulation Research
https://www.readbyqxmd.com/read/29095733/left-lateral-thoracotomy-for-centrifugal-continuous-flow-left-ventricular-assist-device-placement-an-analysis-from-the-mechanical-circulatory-support-research-network
#14
Simon Maltais, Lucman A Anwer, Vakhtang Tchantchaleishvili, Nicholas A Haglund, Shannon M Dunlay, Keith D Aaronson, Francis D Pagani, Jennifer Cowger, Christopher T Salerno, Palak Shah, Zain Khalpey, Jan Schmitto, John M Stulak
Continuous-flow left ventricular assist devices (CF-LVADs) have revolutionized the management of patients with advanced heart failure. Alternative implant strategies are increasingly used for device placement. We reviewed our experience from the Mechanical Circulatory Support Research Network registry with the HeartWare centrifugal CF-LVAD (HVAD). From May 2004 to August 2015, 1,150 patients underwent primary CF-LVAD implantation at our institutions. Within this group, a total of 283 patients (25%) were implanted with the HVAD...
October 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29062102/arrhythmogenic-cardiomyopathy-related-dsg2-mutations-affect-desmosomal-cadherin-binding-kinetics
#15
Mareike Dieding, Jana Davina Debus, Raimund Kerkhoff, Anna Gaertner-Rommel, Volker Walhorn, Hendrik Milting, Dario Anselmetti
Cadherins are calcium dependent adhesion proteins that establish the intercellular mechanical contact by bridging the gap to adjacent cells. Desmoglein-2 (Dsg2) is a specific cadherin of the cell-cell contact in cardiac desmosomes. Mutations in the DSG2-gene are regarded to cause arrhythmogenic (right ventricular) cardiomyopathy (ARVC) which is a rare but severe heart muscle disease. The molecular pathomechanisms of the vast majority of DSG2 mutations, however, are unknown. Here, we investigated the homophilic binding of wildtype Dsg2 and two mutations which are associated with ARVC...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29056948/association-of-cardiovascular-system-medications-with-cognitive-function-and-dementia-in-older-adults-living-in-nursing-homes-in-australia
#16
Enwu Liu, Suzanne M Dyer, Lisa Kouladjian O'Donnell, Rachel Milte, Clare Bradley, Stephanie L Harrison, Emmanuel Gnanamanickam, Craig Whitehead, Maria Crotty
OBJECTIVE: To examine associations between cardiovascular system medication use with cognition function and diagnosis of dementia in older adults living in nursing homes in Australia. METHODS: As part of a cross-sectional study of 17 Australian nursing homes examining quality of life and resource use, we examined the association between cognitive impairment and cardiovascular medication use (identified using the Anatomical Therapeutic Classification System) using general linear regression and logistic regression models...
June 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29016939/molecular-autopsy-of-sudden-unexplained-deaths-reveals-genetic-predispositions-for-cardiac-diseases-among-young-forensic-cases
#17
Nicole Hellenthal, Anna Gaertner-Rommel, Bärbel Klauke, Lech Paluszkiewicz, Markus Stuhr, Thoralf Kerner, Martin Farr, Klaus Püschel, Hendrik Milting
Aims: Coronary artery disease accounts for the majority of sudden cardiac deaths (SCD) in the older population whereas cardiomyopathies and arrhythmogenic abnormalities predominate in younger SCD victims (<35 years) with a significant genetic component. The elucidation of the pathogenetic cause of death might be relevant for the prevention of further deaths within affected families. Aim of this study was to determine the portion of underlying genetic heart diseases among unexplained putative SCD cases from a large German forensic department...
November 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28821075/rapid-fabrication-of-transparent-film-directly-from-wood-fibers-with-microwave-assisted-ionic-liquids-technology
#18
Pengbo Lu, Fan Cheng, Yanghao Ou, Meiyan Lin, Lingfeng Su, Size Chen, Xilang Yao, Detao Liu
Presently flexibly transparent film or nanopaper from all cellulose was mostly fabricated by assembling cellulose nanofibers disintegrated from macroscopic wood fibers which mostly suffers from potential environmental toxicity or high cost. In this work, we firstly reported an all-cellulose transparent film fabricated by a novel microwave-assisted ionic liquids technology (MILT). The use of MILT for treating the original all-cellulose paper brings nearly 2.6 fold-increases in optical transmission, and 2.0 fold-increases in tensile property compared to those without microwave assistance...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28665038/efficacy-of-a-standardized-extract-of-matricariae-chamomilla-l-melissa-officinalis-l-and-tyndallized-lactobacillus-acidophilus-ha122-in-infantile-colic-an-open-randomized-controlled-trial
#19
M Martinelli, D Ummarino, F P Giugliano, E Sciorio, C Tortora, D Bruzzese, D De Giovanni, I Rutigliano, S Valenti, C Romano, A Campanozzi, E Miele, A Staiano
BACKGROUND: Infant colic (IC) is a prevalent physiological event of infants, which can disrupt the child's home environment. We aimed to investigate the effectiveness of a mixture of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) compared with Lactobacillus reuteri DSM 17938 and with simethicone for the treatment of IC. METHODS: A multicenter randomized comparative study was conducted in infants with colic, according to Rome III criteria, who were randomly assigned to receive M...
December 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28615489/ovarian-fluid-impacts-flagellar-beating-and-biomechanical-metrics-of-sperm-between-alternative-reproductive-tactics
#20
Ian A E Butts, Galina Prokopchuk, Vojtěch Kašpar, Jacky Cosson, Trevor E Pitcher
Alternative reproductive tactics (ARTs) are prevalent in nature, where smaller parasitic males typically have better sperm quality than larger territorial guard males. At present, it is unclear what is causing this phenomenon. Our objective was to gain insights into sperm form and function by examining flagellar beating patterns (beat frequency, wave amplitude, bend length, bend angle, wave velocity) and biomechanical sperm metrics (velocity, hydrodynamic power output, propulsive efficiency) of wild spawning Chinook salmon ARTs...
June 15, 2017: Journal of Experimental Biology
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