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https://www.readbyqxmd.com/read/28432189/safety-and-efficiency-of-a-new-generic-package-labelling-a-before-and-after-study-in-a-simulated-setting
#1
Beate Hennie Garcia, Renate Elenjord, Camilla Bjornstad, Kjell Hermann Halvorsen, Sigurd Hortemo, Steinar Madsen
BACKGROUND: Medication errors are frequent and may cause harm to patients and increase healthcare expenses. AIM: To explore whether a new labelling influences time and errors when preparing medications in accordance with medication charts in an experimental setting. METHOD: We carried out an uncontrolled before and after study with 3 months inbetween experiments. Phase I used original labelling and phase II used new generic labelling. We set up an experimental medicine room, simulating a real-life setting...
April 21, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28415406/pcl-foamed-scaffolds-loaded-with-5-fluorouracil-anti-cancer-drug-prepared-by-an-eco-friendly-route
#2
Aurelio Salerno, Concepción Domingo, Javier Saurina
This study describes a new preparation method, which combines freeze drying and supercritical CO2 foaming approaches, for the preparation of drug delivery scaffolds of polycaprolactone loaded with 5-fluorouracil, an anti-cancer drug, with low solubility in scCO2. It is a principal objective of this work to design a scCO2 strategy to reduce 5-Fu solubility limitations in its homogeneous distribution into a PCL scaffold through the design of an innovative processing method. The design of this process is considered valuable for the development of clean technology in pharmacy and medicine, since most of the active agents have a null solubility in scCO2·Supercritical CO2 is used as a blowing agent to induce polymer foaming by means of the low temperature pressure quench process...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28400254/community-pharmacist-delivered-medicare-annual-wellness-visits-within-a-family-medicine-practice
#3
Taylor A Evans, Patricia H Fabel, Bryan Ziegler
OBJECTIVE: To identify the steps to implement a community pharmacist into a family medicine practice to deliver Medicare Annual Wellness Visits (AWVs). SETTING: Medicine Mart Pharmacy is a locally owned and operated pharmacy that has served the West Columbia, South Carolina, area for over 30 years. The services offered by the pharmacy have expanded over the past 3 years through the addition of a community pharmacy resident. PRACTICE INNOVATION: A stepwise approach was developed for a community pharmacist to identify, market, and establish an AWV service through a collaborative practice agreement with a local family medicine practice...
April 8, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28400253/perceived-sustainability-of-community-telepharmacy-in-north-dakota
#4
David M Scott, Daniel L Friesner, Teri Undem, Gabrielle Anderson, Kelli Sem, Charles D Peterson
OBJECTIVES: To assess the sustainability of the business model underlying the North Dakota Telepharmacy Project (NDTP). SETTING: Of the 38 community pharmacy organizations (14 central, 24 remote), 27 organizations (11 central and 16 remote sites) in North Dakota provided a useable set of responses (71.1% response rate). A twelfth organization (a community pharmacy) ceased operations over the study's time frame and was not included in the data analysis. PRACTICE DESCRIPTION: Emphasis is placed on NDTP community telepharmacies, because the community telepharmacy business model is more established than hospital telepharmacies...
April 8, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28377378/evaluation-of-racial-and-socioeconomic-disparities-in-medication-pricing-and-pharmacy-access-and-services
#5
Marie A Chisholm-Burns, Christina A Spivey, Justin Gatwood, Adam Wiss, Kenneth Hohmeier, Steven R Erickson
PURPOSE: Results of a study to determine if disparities in drug pricing, pharmacy services, and community pharmacy access exist in a Tennessee county with a predominantly minority population are reported. METHODS: A cross-sectional survey of community pharmacies in Shelby County, a jurisdiction with a total population more than 60% composed of racial and ethnic minority groups, was conducted. Data collection included "out-of-pocket" (i.e., cash purchase) prices for generic levothyroxine, methylphenidate, and hydrocodone-acetaminophen; pharmacy hours of operation; availability of selected pharmacy services; and ZIP code-level data on demographics and crime risk...
April 4, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28376815/comparison-of-six-methods-to-estimate-adherence-in-an-art-na%C3%A3-ve-cohort-in-a-resource-poor-setting-which-best-predicts-virological-and-resistance-outcomes
#6
Catherine Orrell, Karen Cohen, Rory Leisegang, David R Bangsberg, Robin Wood, Gary Maartens
BACKGROUND: Incomplete adherence to antiretroviral therapy (ART) results in virologic failure and resistance. It remains unclear which adherence measure best predicts these outcomes. We compared six patient-reported and objective adherence measures in one ART-naïve cohort in South Africa. METHODS: We recruited 230 participants from a community ART clinic and prospectively collected demographic data, CD4 count and HIV-RNA at weeks 0, 16 and 48. We quantified adherence using 3-day self-report (SR), clinic-based pill count (CPC), average adherence by pharmacy refill (PR-average), calculation of medication-free days (PR-gaps), efavirenz therapeutic drug monitoring (TDM) and an electronic adherence monitoring device (EAMD)...
April 4, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28364933/when-technical-achievements-aren-t-enough-lessons-learned-from-efforts-to-catalyze-policy-action-on-supply-chain-in-senegal
#7
Modibo Dicko, Batouo Souare, Lamine Cisse Sarr, Babacar Gueye
Before 2013, Senegal public health supply system was pull-based and fully public-run. Lengthy and recurrent stockouts of essential health products (incl. contraceptives) were the rule, not the exception as they used to strike more than 80% of public service delivery points (SDPs). Following a successful pilot in two districts in 2012, the Senegalese Ministry of Health and Social Action (MSAS) implemented the Informed Push Model (IPM) Project (2013-2016). In its first two years, IPM bridged key gaps and expanded the distribution of contraceptives by private third party logistics operators to all public SDPs in Senegal and nearly eliminated stockouts...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28356213/organizational-readiness-for-change-preceptor-perceptions-regarding-early-immersion-of-student-pharmacists-in-health-system-practice
#8
Kimberly A Sanders, Michael D Wolcott, Jacqueline E McLaughlin, Amanda D'Ostroph, Christopher M Shea, Nicole R Pinelli
PURPOSE: To examine preceptors' perceptions regarding readiness for change pre- and post-implementation of a pilot early immersion program engaging student pharmacists in direct patient care. METHODS: Student pharmacists enrolled in the second professional year of a Doctor of Pharmacy degree program completed a four-week health-system introductory pharmacy practice experience (IPPE) which was modified to include direct patient care roles in operational (drug preparation and dispensing) and clinical (comprehensive medication management) pharmacy environments...
March 10, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28347563/structural-and-elemental-characterization-of-traditional-indian-siddha-formulation-thalagak-karuppu
#9
N Kannan, S Balaji, N V Anil Kumar
BACKGROUND: The traditional Indian medicine 'Siddha' uses metals, metalloids and minerals including toxic ones with no proven toxicity. Thalagak karuppu (TK) is remarkably stable over a century and used for treating Suram (Fever), Kaasam (Cough), Elai (Tuberculosis) and Eraippu Erumal (Bronchial Asthma). OBJECTIVE: The present study addresses elemental and morphological characterization of therapeutic Siddha formulation: Thalagak karuppu (TK). MATERIALS AND METHODS: TK was purchased from the Indian Medical Practitioners Co-operative Pharmacy and Stores (IMCOPS) Ltd, Chennai, Tamilnadu, India...
March 24, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28346209/accuracy-considerations-in-sterile-compounding
#10
Michael J Akers
Published information about the accuracy of filling and closing operations of sterile products is limited and guidelines on the topic are very general. This article highlights the basic principles in sterile-product filling of syringes and vials. Also covered in this article are descriptions of some of the available devices for filling containers, a brief discussion of the advances in vial and syringe filling, a discussion on the advantages and disadvantages of sterile product filling methods, and a discussion on possible problems encountered during filling operations...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28333673/choosing-a-vial-processing-line-for-aseptic-compounding-part-1
#11
Shaun Noorian, Navid Vahedi
Equipment systems that enable compliance with stringent state and federal compounding requirements are a topic of increasing interest to U.S. pharmacists. Of those equipment types, an aseptic vial processing line offers unique benefits (especially to 503B compounding pharmacies and small contract manufacturers of aseptic pilot-size batches) if the volume of sterile preparations dispensed offsets the cost of purchase, installation, and maintenance. In this article, the reasons for and the process of selecting an aseptic vial processing line for use in 2 independent 503B compounding pharmacies are presented, the operation of our choice of equipment is described, and specifications for the components of that line are listed...
July 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28333179/obtaining-antibiotics-online-from-within-the-uk-a-cross-sectional-study
#12
Sara Elizabeth Boyd, Luke Stephen Prockter Moore, Mark Gilchrist, Ceire Costelloe, Enrique Castro-Sánchez, Bryony Dean Franklin, Alison Helen Holmes
Background: Improved antibiotic stewardship (AS) and reduced prescribing in primary care, with a parallel increase in personal internet use, could lead citizens to obtain antibiotics from alternative sources online. Objectives: A cross-sectional analysis was performed to: (i) determine the quality and legality of online pharmacies selling antibiotics to the UK public; (ii) describe processes for obtaining antibiotics online from within the UK; and (iii) identify resulting AS and patient safety issues...
February 17, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28321301/early-aspirin-administration-post-coronary-artery-bypass-graft-surgery-changing-hospital-culture-through-a-two-cycled-audit
#13
Shefali Parikh, Justin Ratnasingham
"Early Aspirin" or a medium dose of aspirin 6 hours after Coronary Artery Bypass Graft (CABG) Surgery is strongly recommend by international guidelines (EACTS 2007/AHA 2011 guidelines, Level1a evidence) to protect venous graft patency. However, compliance with Early Aspirin prescription at our centre is poor due to long standing hospital cultural practices and lack of awareness. We completed a two-cycled retrospective audit of 53 (September 2015 Baseline), 65 (January 2016 First Cycle) and 58 (June 2016 Second Cycle) consecutive CABG patients...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28319507/recombinant-factor-viia-is-associated-with-increased-thrombotic-complications-in-pediatric-cardiac-surgery-patients
#14
Laura Downey, Morgan L Brown, David Faraoni, David Zurakowski, James A DiNardo
BACKGROUND: Recombinant factor VIIa (rFVIIa) is routinely used as an off-label hemostatic agent in children undergoing cardiac surgery. Despite evidence that rFVIIa use is associated with an increased incidence of thrombotic complications in adult cardiac surgery, the safety of rFVIIa as a rescue hemostatic agent in the pediatric cardiac surgical population is less definitively delineated. In this retrospective study, we used propensity score matching to compare the incidence of thrombotic complications between children treated with rFVIIa and their matched controls...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28293104/factors-driving-customers-to-seek-health-care-from-pharmacies-for-acute-respiratory-illness-and-treatment-recommendations-from-drug-sellers-in-dhaka-city-bangladesh
#15
Fahmida Chowdhury, Katharine Sturm-Ramirez, Abdullah Al Mamun, A Danielle Iuliano, Mejbah Uddin Bhuiyan, Mohammod Jobayer Chisti, Makhdum Ahmed, Sabbir Haider, Mahmudur Rahman, Eduardo Azziz-Baumgartner
BACKGROUND: Pharmacies in Bangladesh serve as an important source of health service. A survey in Dhaka reported that 48% of respondents with symptoms of acute respiratory illness (ARI) identified local pharmacies as their first point of care. This study explores the factors driving urban customers to seek health care from pharmacies for ARI, their treatment adherence, and outcome. METHODS: A cross-sectional study was conducted among 100 selected pharmacies within Dhaka from June to December 2012...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28274979/strategies-that-facilitated-expansion-of-a-postgraduate-year-1-pharmacy-residency-program-across-a-community-hospital-based-health-system
#16
Andrew Ticcioni, Diane Erdman, Benjamin Scott, Mike Gillard, Lijian Cai
PURPOSE: Seven strategies used to expand an existing postgraduate year 1 (PGY1) pharmacy residency program and launch 3 new PGY1 residency programs in a multisite community hospital-based health system are described. SUMMARY: The vision of ASHP and other pharmacy organizations of providing advanced training (e.g., residency training) to all pharmacists who plan to be involved in direct patient care has not yet been realized, and the capacity to provide such training has not kept pace with the demand...
March 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28250329/pharmacists-advice-about-driving-for-diabetic-patients
#17
Masako Satake
 In November 2013, the Japanese Ministry of Health, Labour and Welfare issued a directive that required the revision of the package inserts of 13 substances whose consumption carries risks associated with driving and the operation of machinery due to their side effects, such as dizziness. Medical personnel are required to remind patients taking these drugs about the risks, but the abovementioned directive did not apply to any antidiabetic drugs at that point. In January 2014, it was decided that patients should "pay attention while driving and at the workplace" when taking any antidiabetic drugs...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28236801/implementation-of-an-e-interconsultation-system-between-a-hospital-pharmacy-service-and-primary-care-pharmacy-units-in-a-health-area
#18
Marta García-Queiruga, Luis Margusino-Framiñán, Isabel Martín-Herranz, Miguel Gutiérrez-Estoa, Xosé Güeto-Rial, Judith Capitán-Guarnizo, Alfredo Silva-Tojo
PURPOSE: To present the requirements, development, structure and results of an electronic interconsultation platform (e-Interconsultation) for communication between primary and hospital care. METHOD: A working group was created and set out its purposes, working schedule, software requirements, the structure of the electronic platform, validation procedure, and its implementation. Once the software had been developed and validated and training sessions were conducted, the electronicplatform was launched in June 2015...
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28230455/outcomes-of-pharmacy-led-hepatitis-c-direct-acting-antiviral-utilization-management-at-a-veterans-affairs-medical-center
#19
Sendra Yang, Rachel B Britt, Mohamed G Hashem, Jamie N Brown
BACKGROUND: The Veterans Affairs Health (VA) Administration has reported hepatitis C virus (HCV) infection rates among veterans to be twice that of the general U.S population. New HCV direct-acting antiviral (DAA) treatment options offer superior sustained virologic response (SVR) rates, improved side-effect profiles, and shortened treatment courses; yet, these new HCV DAAs are expensive, and utilization management strategies are needed to optimize use and improve clinical outcomes. A VA medical center uses pharmacist-led HCV DAA utilization management strategies that includes clinical guidance, optimizing operational flow, budget tracking and forecasting, and patient outcomes tracking...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28210883/can-demographic-clinical-and-treatment-related-factors-available-at-hormonal-therapy-initiation-predict-non-persistence-in-women-with-stage-i-iii-breast-cancer
#20
Caitriona Cahir, Thomas I Barron, Linda Sharp, Kathleen Bennett
PURPOSE: To investigate whether demographic, clinical and treatment-related risk factors known at treatment initiation can be used to reliably predict future hormonal therapy non-persistence in women with breast cancer, and to inform intervention development. METHODS: Women with stage I-III breast cancer diagnosed 2000-2012 and prescribed hormonal therapy were identified from the National Cancer Registry Ireland (NCRI) and linked to pharmacy claims data from Ireland's Primary Care Reimbursement Services (PCRS)...
March 2017: Cancer Causes & Control: CCC
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