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https://www.readbyqxmd.com/read/29145528/auricular-prostheses-produced-by-means-of-conventional-and-digital-workflows-a-clinical-report-on-esthetic-outcomes
#1
Alexey Unkovskiy, Joern Brom, Fabian Huettig, Constanze Keutel
The utilization of additive manufacturing (AM) technology for the production of auricular prostheses has been widely acknowledged. However, few studies and case history reports have evaluated the esthetic outcomes of AM prostheses compared to those of conventionally manufactured prostheses. In this case history report, three manufacturing approaches-conventional, indirect, and direct mold preparation-were assessed for their esthetic outcomes in the same patient.
November 16, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29145487/defining-external-factors-that-determine-neuronal-survival-apoptosis-and-necrosis-during-excitotoxic-injury-using-a-high-content-screening-imaging-platform
#2
Ujval Anilkumar, Petronela Weisova, Jasmin Schmid, Tytus Bernas, Heinrich J Huber, Heiko Düssmann, Niamh M C Connolly, Jochen H M Prehn
Cell death induced by excessive glutamate receptor overactivation, excitotoxicity, has been implicated in several acute and chronic neurological disorders. While numerous studies have demonstrated the contribution of biochemically and genetically activated cell death pathways in excitotoxic injury, the factors mediating passive, excitotoxic necrosis are less thoroughly investigated. To address this question, we developed a high content screening (HCS) based assay to collect high volumes of quantitative cellular imaging data and elucidated the effects of intrinsic and external factors on excitotoxic necrosis and apoptosis...
2017: PloS One
https://www.readbyqxmd.com/read/29145156/the-potential-of-ion-mobility-mass-spectrometry-for-high-throughput-and-high-resolution-lipidomics
#3
REVIEW
Christine Hinz, Sonia Liggi, Julian L Griffin
Lipids are a large and highly diverse family of biomolecules, which play essential structural, storage and signalling roles in cells and tissues. Although traditional mass spectrometry (MS) approaches used in lipidomics are highly sensitive and selective, lipid analysis remains challenging due to the chemical diversity of lipid structures, multiple isobaric species and incomplete separation using many forms of chromatography. Ion mobility (IM) separates ions in the gas phase based on their physicochemical properties...
November 13, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29144151/workflow-interruptions-and-employee-work-outcomes-the-moderating-role-of-polychronicity
#4
Daniela Pachler, Angela Kuonath, Julia Specht, Silja Kennecke, Maria Agthe, Dieter Frey
Workflow interruptions are one of the most commonly experienced stressors at work. This research expands existing literature on workflow interruptions in a diary field study. We apply a within-person approach and investigate detrimental effects of daily workflow interruptions on both daily satisfaction with performance and daily emotional exhaustion. Furthermore, we introduce polychronicity (the trait-like preference of a person to deal with several activities at the same time) as a buffering factor in this relationship...
November 16, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/29143816/quantitative-microbiome-profiling-links-gut-community-variation-to-microbial-load
#5
Doris Vandeputte, Gunter Kathagen, Kevin D'hoe, Sara Vieira-Silva, Mireia Valles-Colomer, João Sabino, Jun Wang, Raul Y Tito, Lindsey De Commer, Youssef Darzi, Séverine Vermeire, Gwen Falony, Jeroen Raes
Current sequencing-based analyses of faecal microbiota quantify microbial taxa and metabolic pathways as fractions of the sample sequence library generated by each analysis. Although these relative approaches permit detection of disease-associated microbiome variation, they are limited in their ability to reveal the interplay between microbiota and host health. Comparative analyses of relative microbiome data cannot provide information about the extent or directionality of changes in taxa abundance or metabolic potential...
November 15, 2017: Nature
https://www.readbyqxmd.com/read/29143640/how-is-the-lives-saved-tool-list-used-in-the-global-health-community-results-of-a-mixed-methods-list-user-study
#6
Angela R Stegmuller, Andrew Self, Kate Litvin, Timothy Roberton
BACKGROUND: The Lives Saved Tool (LiST) is a computer-based model that estimates the impact of scaling up key interventions to improve maternal, newborn and child health. Initially developed to inform the Lancet Child Survival Series of 2003, the functionality and scope of LiST have been expanded greatly over the past 10 years. This study sought to "take stock" of how LiST is now being used and for what purposes. METHODS: We conducted a quantitative survey of LiST users, qualitative interviews with a smaller sample of LiST users and members of the LiST team at Johns Hopkins University, and a literature review of studies involving LiST analyses...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29142808/analyzing-microtomography-data-with-python-and-the-scikit-image-library
#7
Emmanuelle Gouillart, Juan Nunez-Iglesias, Stéfan van der Walt
The exploration and processing of images is a vital aspect of the scientific workflows of many X-ray imaging modalities. Users require tools that combine interactivity, versatility, and performance. scikit-image is an open-source image processing toolkit for the Python language that supports a large variety of file formats and is compatible with 2D and 3D images. The toolkit exposes a simple programming interface, with thematic modules grouping functions according to their purpose, such as image restoration, segmentation, and measurements...
2017: Advanced Structural and Chemical Imaging
https://www.readbyqxmd.com/read/29142646/integrating-3d-facial-scanning-in-a-digital-workflow-to-cad-cam-design-and-fabricate-complete-dentures-for-immediate-total-mouth-rehabilitation
#8
Bassam Hassan, Marcus Greven, Daniel Wismeijer
PURPOSE: To integrate extra-oral facial scanning information with CAD/CAM complete dentures to immediately rehabilitate terminal dentition. MATERIALS AND METHODS: Ten patients with terminal dentition scheduled for total extraction and immediate denture placement were recruited for this study. The patients were submitted to a facial scanning procedure using the in-office PritiMirror scanner with bite registration records in-situ. Definitive stone cast models and bite records were subsequently submitted to a lab scanning procedure using the lab scanner (iSeries DWOS; Dental Wings)...
October 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29140295/quantification-of-cardiovascular-disease-biomarkers-in-human-platelets-by-targeted-mass-spectrometry
#9
Sebastian Malchow, Christina Loosse, Albert Sickmann, Christin Lorenz
Platelets are known to be key players in thrombosis and hemostasis, contributing to the genesis and progression of cardiovascular diseases. Due to their pivotal role in human physiology and pathology, platelet function is regulated tightly by numerous factors which have either stimulatory or inhibitory effects. A variety of factors, e.g., collagen, fibrinogen, ADP, vWF, thrombin, and thromboxane promote platelet adhesion and aggregation by utilizing multiple intracellular signal cascades. To quantify platelet proteins for this work, a targeted proteomics workflow was applied...
November 15, 2017: Proteomes
https://www.readbyqxmd.com/read/29138947/a-posteriori-metadata-from-automated-provenance-tracking-integration-of-aiida-and-tcod
#10
Andrius Merkys, Nicolas Mounet, Andrea Cepellotti, Nicola Marzari, Saulius Gražulis, Giovanni Pizzi
In order to make results of computational scientific research findable, accessible, interoperable and re-usable, it is necessary to decorate them with standardised metadata. However, there are a number of technical and practical challenges that make this process difficult to achieve in practice. Here the implementation of a protocol is presented to tag crystal structures with their computed properties, without the need of human intervention to curate the data. This protocol leverages the capabilities of AiiDA, an open-source platform to manage and automate scientific computational workflows, and the TCOD, an open-access database storing computed materials properties using a well-defined and exhaustive ontology...
November 14, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29136797/unparalleled-sample-treatment-throughput-for-proteomics-workflows-relying-on-ultrasonic-energy
#11
Susana Jorge, J E Araújo, F M Pimentel-Santos, Jaime C Branco, Hugo M Santos, Carlos Lodeiro, J L Capelo
We report on the new microplate horn ultrasonic device as a powerful tool to speed proteomics workflows with unparalleled throughput. 96 complex proteomes were digested at the same time in 4min. Variables such as ultrasonication time, ultrasonication amplitude, and protein to enzyme ratio were optimized. The "classic" method relying on overnight protein digestion (12h) and the sonoreactor-based method were also employed for comparative purposes. We found the protein digestion efficiency homogeneously distributed in the entire microplate horn surface using the following conditions: 4min sonication time and 25% amplitude...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29135997/performances-of-the-piper-scalable-child-human-body-model-in-accident-reconstruction
#12
Chiara Giordano, Xiaogai Li, Svein Kleiven
Human body models (HBMs) have the potential to provide significant insights into the pediatric response to impact. This study describes a scalable/posable approach to perform child accident reconstructions using the Position and Personalize Advanced Human Body Models for Injury Prediction (PIPER) scalable child HBM of different ages and in different positions obtained by the PIPER tool. Overall, the PIPER scalable child HBM managed reasonably well to predict the injury severity and location of the children involved in real-life crash scenarios documented in the medical records...
2017: PloS One
https://www.readbyqxmd.com/read/29135850/incorporating-nurse-input-and-evidence-into-a-newly-designed-unit-to-improve-patient-and-nursing-outcomes
#13
Jennifer Tafelmeyer, Robin Wicks, Jeannine Brant, Laurie Smith
OBJECTIVE: The aim of this study was to identify processes, outcomes, and lessons learned from designing a new evidence-based unit. A research study was conducted simultaneously to rigorously measure changes in patient and staff outcomes. BACKGROUND: Nursing leadership and frontline nursing engagement are critical in evidence-based design to promote positive outcomes and workflow. METHODS: Quality indicators were tracked premove and postmove...
December 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29135754/implementation-of-a-pediatric-behavioral-staffing-algorithm-in-an-acute-hospital-a-best-practice-implementation-project
#14
Tamara O'Connor
BACKGROUND: A progressive decline in acute psychiatric facility beds has led to a steadily increasing number of pediatric psychiatric patients hospitalized on acute care medical-surgical units. Clinical nurses in this environment feel ill-equipped to provide quality behavioral health care. AIMS/OBJECTIVES: This project aimed to improve continuity of care as well as staff and patient safety in pediatric acute and transitional care units. The specific objectives related to implementation of a resource allocation algorithm for staffing behavioral health admissions and consistent use of an interdisciplinary psychiatric huddle...
November 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29134591/sequencing-assembling-and-finishing-complete-bacteriophage-genomes
#15
Daniel A Russell
Next-generation DNA sequencing (NGS) technologies have made generating genomic sequence for organisms of interest affordable and commonplace. However, NGS platforms and analysis software are generally tuned to be used on large and complex genomes or metagenomic samples. Determining the complete genome sequence of a single bacteriophage requires a somewhat different perspective, workflow, and sensitivity to the nature of phages. Because phage genomes consist of mostly coding regions (see Pope/Jacobs-Sera chapter), a very high standard should be adopted when completing these genomes so that the subsequent steps of annotation and analysis are not sabotaged by sequencing errors...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29134431/impact-of-domain-knowledge-on-blinded-predictions-of-binding-energies-by-alchemical-free-energy-calculations
#16
Antonia S J S Mey, Jordi Juárez Jiménez, Julien Michel
The Drug Design Data Resource (D3R) consortium organises blinded challenges to address the latest advances in computational methods for ligand pose prediction, affinity ranking, and free energy calculations. Within the context of the second D3R Grand Challenge several blinded binding free energies predictions were made for two congeneric series of Farsenoid X Receptor (FXR) inhibitors with a semi-automated alchemical free energy calculation workflow featuring FESetup and SOMD software tools. Reasonable performance was observed in retrospective analyses of literature datasets...
November 13, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29132876/the-distraction-in-action-tool%C3%A2-feasibility-and-usability-in-clinical-settings
#17
Kirsten Hanrahan, Charmaine Kleiber, Ben J Miller, Heather Davis, Ann Marie McCarthy
PURPOSE: Distraction is a relatively simple, evidence-based intervention to minimize child distress during medical procedures. Timely on-site interventions that instruct parents on distraction coaching are needed. The purpose of this study was to test the feasibility and usability of the Distraction in Action Tool© (DAT©), which 1) predicts child risk for distress with a needle stick and 2) provides individualized instructions for parents on how to be a distraction coach for their child in clinical settings...
November 10, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29132696/development-and-validation-of-an-automated-ventilator-associated-event-electronic-surveillance-system-a-report-of-a-successful-implementation
#18
Courtney Hebert, Jennifer Flaherty, Justin Smyer, Jing Ding, Julie E Mangino
BACKGROUND: Surveillance is an important tool for infection control; however, this task can often be time-consuming and take away from infection prevention activities. With the increasing availability of comprehensive electronic health records, there is an opportunity to automate these surveillance activities. The objective of this article is to describe the implementation of an electronic algorithm for ventilator-associated events (VAEs) at a large academic medical center METHODS: This article reports on a 6-month manual validation of a dashboard for VAEs...
November 10, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29132638/impact-of-an-integrated-electronic-handover-tool-on-pediatric-junior-medical-staff-jms-handover
#19
Daryl R Cheng, James Liddle, Emily Mailes, Mike South
BACKGROUND: Clinical medical handover between doctors forms a critical part of the patient care process. However, with the evolution of junior medical staff (JMS) working conditions, time pressure and increasing clinical and administrative loads mean that quality clinical handover is increasingly important yet more challenging to achieve. This study evaluated the impact of a newly integrated electronic handover tool on JMS adoption and usage of the tool, as well as impacts on the quality (accuracy and redundancy) of handover data, JMS perceived workflow (time management and communication) and JMS satisfaction...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29132408/using-semantics-for-representing-experimental-protocols
#20
Olga Giraldo, Alexander García, Federico López, Oscar Corcho
BACKGROUND: An experimental protocol is a sequence of tasks and operations executed to perform experimental research in biological and biomedical areas, e.g. biology, genetics, immunology, neurosciences, virology. Protocols often include references to equipment, reagents, descriptions of critical steps, troubleshooting and tips, as well as any other information that researchers deem important for facilitating the reusability of the protocol. Although experimental protocols are central to reproducibility, the descriptions are often cursory...
November 13, 2017: Journal of Biomedical Semantics
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