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REVIEW
Akshay Sood, Amar U Kishan, Christopher P Evans, Felix Y Feng, Todd M Morgan, Declan G Murphy, Anwar R Padhani, Peter Pinto, Henk G Van der Poel, Derya Tilki, Alberto Briganti, Firas Abdollah
CONTEXT: The clinical introduction of next-generation imaging methods and molecular biomarkers ("radiogenomics") has revolutionized the field of prostate cancer (PCa). While the clinical validity of these tests has thoroughly been vetted, their clinical utility remains a matter of investigation. OBJECTIVE: To systematically review the evidence to date on the impact of positron emission tomography (PET) imaging and tissue-based prognostic biomarkers, including Decipher, Prolaris, and Oncotype Dx, on the risk stratification, treatment choice, and oncological outcomes of men with newly diagnosed PCa or those with biochemical failure (BCF)...
July 7, 2023: European Urology Oncology
#22
EDITORIAL
Anwar R Padhani, Ivo G Schoots
No abstract text is available yet for this article.
June 2023: Radiology
#23
JOURNAL ARTICLE
Jai K Das, Faareha Siddiqui, Zahra Ali Padhani, Maryam Hameed Khan, Sultana Jabeen, Mushtaq Mirani, Shaista Mughal, Shafaq Baloch, Imtiaz Sheikh, Sana Khatoon, Khan Muhammad, Manesh Gangwani, Karim Nathani, Rehana A Salam, Zulfiqar A Bhutta
Diarrhea and pneumonia are the leading causes of morbidity and mortality in children under five, and Pakistan is amongst the countries with the highest burden and low rates of related treatment coverage. We conducted a qualitative study as part of the formative phase to inform the design of the Community Mobilization and Community Incentivization (CoMIC) cluster randomized control trial (NCT03594279) in a rural district of Pakistan. We conducted in-dept interviews and focused group discussions with key stakeholders using a semi-structured study guide...
2023: PloS One
#24
EDITORIAL
Patrick Asbach, Anwar R Padhani
No abstract text is available yet for this article.
May 8, 2023: European Radiology
#25
JOURNAL ARTICLE
Anwar R Padhani, Ivo G Schoots
OBJECTIVE: To comprehensively review the literature on the integration of MRI as a diagnostic tool in prostate cancer screening and offer practical recommendations for optimising its use. METHODS: Existing research studies, clinical guidelines and expert opinions were reviewed to support the optimisation standards for MRI use in screening. Consolidated screening principles were used to make appropriate recommendations regarding the integration of MRI into the diagnostic pathway...
May 8, 2023: European Radiology
#26
JOURNAL ARTICLE
David Eldred-Evans, Henry Tam, Heminder Sokhi, Anwar R Padhani, Martin Connor, Derek Price, Martin Gammon, Natalia Klimowska-Nassar, Paula Burak, Emily Day, Mathias Winkler, Francesca Fiorentino, Hashim U Ahmed
BACKGROUND: The use of prostate-specific antigen (PSA) testing to screen for prostate cancer has been fraught with under- and overdiagnosis. Short, noncontrast magnetic resonance imaging (MRI) might detect more grade group ≥2 cancers with similar rates of biopsy. OBJECTIVE: To evaluate strategies that combined PSA and MRI to select men based in the community for a prostate biopsy. DESIGN, SETTING, AND PARTICIPANTS: IP1-PROSTAGRAM was a prospective, population-based, paired cohort study of 408 men aged 50-69 yr conducted at seven UK primary care practice and two imaging centres (from October 10, 2018 to May 15, 2019)...
June 2023: European Urology Oncology
#27
JOURNAL ARTICLE
Zahra A Padhani, Jai K Das, Faareha A Siddiqui, Rehana A Salam, Zohra S Lassi, Durray Shahwar A Khan, Ammaar M A Abbasi, Emily C Keats, Sajid Soofi, Robert E Black, Zulfiqar A Bhutta
CONTEXT: The timing of introducing complementary feeding (CF) is crucial because premature or delayed CF can be associated with adverse health outcomes in childhood and adulthood. OBJECTIVE: This systematic review aims to evaluate the impact of the timing of CF introduction on health, nutrition, and developmental outcomes among normal-term infants. DATA SOURCES: Electronic databases and trial registries were searched, along with the reference lists of the included studies and relevant systematic reviews...
April 4, 2023: Nutrition Reviews
#28
JOURNAL ARTICLE
Silke Gillessen, Alberto Bossi, Ian D Davis, Johann de Bono, Karim Fizazi, Nicholas D James, Nicolas Mottet, Neal Shore, Eric Small, Matthew Smith, Christopher J Sweeney, Bertrand Tombal, Emmanuel S Antonarakis, Ana M Aparicio, Andrew J Armstrong, Gerhardt Attard, Tomasz M Beer, Himisha Beltran, Anders Bjartell, Pierre Blanchard, Alberto Briganti, Rob G Bristow, Muhammad Bulbul, Orazio Caffo, Daniel Castellano, Elena Castro, Heather H Cheng, Kim N Chi, Simon Chowdhury, Caroline S Clarke, Noel Clarke, Gedske Daugaard, Maria De Santis, Ignacio Duran, Ross Eeles, Eleni Efstathiou, Jason Efstathiou, Onyeanunam Ngozi Ekeke, Christopher P Evans, Stefano Fanti, Felix Y Feng, Valerie Fonteyne, Nicola Fossati, Mark Frydenberg, Dan George, Martin Gleave, Gwenaelle Gravis, Susan Halabi, Daniel Heinrich, Ken Herrmann, Celestia Higano, Michael S Hofman, Lisa G Horvath, Maha Hussain, Barbara A Jereczek-Fossa, Rob Jones, Ravindran Kanesvaran, Pirkko-Liisa Kellokumpu-Lehtinen, Raja B Khauli, Laurence Klotz, Gero Kramer, Raja Leibowitz, Christopher Logothetis, Brandon Mahal, Fernando Maluf, Joaquin Mateo, David Matheson, Niven Mehra, Axel Merseburger, Alicia K Morgans, Michael J Morris, Hind Mrabti, Deborah Mukherji, Declan G Murphy, Vedang Murthy, Paul L Nguyen, William K Oh, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Carmel J Pezaro, Darren M C Poon, Colin C Pritchard, Danny M Rabah, Dana Rathkopf, Robert E Reiter, Mark A Rubin, Charles J Ryan, Fred Saad, Juan Pablo Sade, Oliver Sartor, Howard I Scher, Nima Sharifi, Iwona Skoneczna, Howard Soule, Daniel E Spratt, Sandy Srinivas, Cora N Sternberg, Thomas Steuber, Hiroyoshi Suzuki, Matthew R Sydes, Mary-Ellen Taplin, Derya Tilki, Levent Türkeri, Fabio Turco, Hiroji Uemura, Hirotsugu Uemura, Yüksel Ürün, Claire L Vale, Inge van Oort, Neha Vapiwala, Jochen Walz, Kosj Yamoah, Dingwei Ye, Evan Y Yu, Almudena Zapatero, Thomas Zilli, Aurelius Omlin
BACKGROUND: Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant to making management decisions in daily clinical practise. The 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) addressed some questions in these areas to supplement guidelines that mostly are based on level 1 evidence. OBJECTIVE: To present the voting results of the APCCC 2022...
May 2023: European Journal of Cancer
#29
JOURNAL ARTICLE
David Eldred-Evans, Mathias Winkler, Natalia Klimowska-Nassar, Paula Burak, Martin J Connor, Francesca Fiorentino, Emily Day, Derek Price, Martin Gammon, Henry Tam, Heminder Sokhi, Anwar R Padhani, Hashim U Ahmed
BACKGROUND: The IP1-PROSTAGRAM study showed that a short, non-contrast MRI detected more significant cancers with similar rates of biopsy compared to PSA. Herein, we compare the expected and perceived burden of PSA, MRI and ultrasound as screening tests. METHODS: IP1-PROSTAGRAM was a prospective, population-based, paired screening study of 408 men conducted at seven UK primary care practices and two imaging centres. The screening tests were serum PSA, non-contrast MRI and ultrasound...
March 31, 2023: Prostate Cancer and Prostatic Diseases
#30
REVIEW
Bernardette Cichon, Jai K Das, Rehana A Salam, Zahra A Padhani, Heather C Stobaugh, Muzna Mughal, Patrizia Pajak, Alexandra Rutishauser-Perera, Zulfiqar A Bhutta, Robert E Black
Currently, no World Health Organization guidelines exist for the management of approximately 31.8 million moderately wasted children globally. The objective of this review was to synthesise evidence on the optimal type, quantity, and duration of dietary treatment for moderate wasting. Ten electronic databases were searched until the 23rd of August 2021. Experimental studies comparing interventions for the dietary management of moderate wasting were included. Meta-analyses were conducted and results were presented as risk ratios or mean differences with 95% confidence intervals...
February 21, 2023: Nutrients
#31
JOURNAL ARTICLE
Anand Sharma, Amish Lakhani, Subhadip Ghosh-Ray, Salma Alam, Anwar Padhani, Andrew Gogbashian, Paul Nathan
BACKGROUND/AIM: Treatment for advanced renal cell carcinoma (aRCC) comprises single agent or combinations of immune checkpoint inhibitors and/or anti-angiogenic agents. Pazopanib is a multitargeted anti-angiogenic tyrosine kinase inhibitor (TKI) approved as treatment for aRCC. We noted that a number of patients receiving pazopanib developed a radiological finding of small bowel lipomatosis. To evaluate the incidence of small bowel lipomatosis in patients with aRCC on treatment with pazopanib in comparison with other tyrosine kinase inhibitors...
February 2023: Anticancer Research
#32
Prem Chand, Zahra Ali Padhani, Rozmeen Akbar, Fazal Arain
Hypermanganesaemia with dystonia, polycythemia, and cirrhosis (HMDPC) is a rare genetic and autosomal recessive disorder that occurs due to mutation of the SLC3A10 gene, which encodes the manganese (Mn) transporter in the body; as a result, Mn accumulates in the brain, liver and muscles. This accumulation leads to symptoms of generalized dystonia, polycythemia, and hypermanganesaemia. In this report, we present the case of a 2½-year-old baby girl (patient) with complaints of lower limb weakness and increased difficulty in walking for six months...
October 2022: JPMA. the Journal of the Pakistan Medical Association
#33
JOURNAL ARTICLE
Silke Gillessen, Alberto Bossi, Ian D Davis, Johann de Bono, Karim Fizazi, Nicholas D James, Nicolas Mottet, Neal Shore, Eric Small, Mathew Smith, Christopher Sweeney, Bertrand Tombal, Emmanuel S Antonarakis, Ana M Aparicio, Andrew J Armstrong, Gerhardt Attard, Tomasz M Beer, Himisha Beltran, Anders Bjartell, Pierre Blanchard, Alberto Briganti, Rob G Bristow, Muhammad Bulbul, Orazio Caffo, Daniel Castellano, Elena Castro, Heather H Cheng, Kim N Chi, Simon Chowdhury, Caroline S Clarke, Noel Clarke, Gedske Daugaard, Maria De Santis, Ignacio Duran, Ros Eeles, Eleni Efstathiou, Jason Efstathiou, Onyeanunam Ngozi Ekeke, Christopher P Evans, Stefano Fanti, Felix Y Feng, Valerie Fonteyne, Nicola Fossati, Mark Frydenberg, Daniel George, Martin Gleave, Gwenaelle Gravis, Susan Halabi, Daniel Heinrich, Ken Herrmann, Celestia Higano, Michael S Hofman, Lisa G Horvath, Maha Hussain, Barbara Alicja Jereczek-Fossa, Robert Jones, Ravindran Kanesvaran, Pirkko-Liisa Kellokumpu-Lehtinen, Raja B Khauli, Laurence Klotz, Gero Kramer, Raya Leibowitz, Christopher J Logothetis, Brandon A Mahal, Fernando Maluf, Joaquin Mateo, David Matheson, Niven Mehra, Axel Merseburger, Alicia K Morgans, Michael J Morris, Hind Mrabti, Deborah Mukherji, Declan G Murphy, Vedang Murthy, Paul L Nguyen, William K Oh, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Carmel Pezaro, Darren M C Poon, Colin C Pritchard, Danny M Rabah, Dana Rathkopf, Robert E Reiter, Mark A Rubin, Charles J Ryan, Fred Saad, Juan Pablo Sade, Oliver A Sartor, Howard I Scher, Nima Sharifi, Iwona Skoneczna, Howard Soule, Daniel E Spratt, Sandy Srinivas, Cora N Sternberg, Thomas Steuber, Hiroyoshi Suzuki, Matthew R Sydes, Mary-Ellen Taplin, Derya Tilki, Levent Türkeri, Fabio Turco, Hiroji Uemura, Hirotsugu Uemura, Yüksel Ürün, Claire L Vale, Inge van Oort, Neha Vapiwala, Jochen Walz, Kosj Yamoah, Dingwei Ye, Evan Y Yu, Almudena Zapatero, Thomas Zilli, Aurelius Omlin
BACKGROUND: Innovations in imaging and molecular characterisation and the evolution of new therapies have improved outcomes in advanced prostate cancer. Nonetheless, we continue to lack high-level evidence on a variety of clinical topics that greatly impact daily practice. To supplement evidence-based guidelines, the 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) surveyed experts about key dilemmas in clinical management. OBJECTIVE: To present consensus voting results for select questions from APCCC 2022...
March 2023: European Urology
#34
Om Parkash, Asra Tus Saleha Siddiqui, Uswa Jiwani, Fahad Rind, Zahra Ali Padhani, Arjumand Rizvi, Zahra Hoodbhoy, Jai K Das
BACKGROUND: Artificial Intelligence (AI) holds considerable promise for diagnostics in the field of gastroenterology. This systematic review and meta-analysis aims to assess the diagnostic accuracy of AI models compared with the gold standard of experts and histopathology for the diagnosis of various gastrointestinal (GI) luminal pathologies including polyps, neoplasms, and inflammatory bowel disease. METHODS: We searched PubMed, CINAHL, Wiley Cochrane Library, and Web of Science electronic databases to identify studies assessing the diagnostic performance of AI models for GI luminal pathologies...
2022: Frontiers in Medicine
#35
JOURNAL ARTICLE
Prem Chand, Tipu Sultan, Shazia Kulsoom, Farida Jan, Shahnaz Ibrahim, Khairunnisa Mukhtiar, Safia Awan, Ibrar Rafique, Durray Shahwar A Khan, Asna Sulaiman, Muhammad Arif Nadeem Saqib, Muhammad Sajid, Zahra Ali Padhani, Jai K Das, Shazia Soomro, Mohammad Wasay
BACKGROUND: There is dearth of information on the spectrum of neurological disorders among children less than 18 years of age. The aim of this study is to identify the commonly presenting neurological disorders among children aged ≤ 18 years in Pakistan. METHODS: We conducted a cross-sectional study at three tertiary care hospitals in Pakistan. RESULTS: A total of 17,176 children were included in our study; 61.8% were boys and 38.2% females...
October 7, 2022: Pediatric Neurology
#36
JOURNAL ARTICLE
Jai K Das, Zahra Ali Padhani
No abstract text is available yet for this article.
November 2022: Lancet Global Health
#37
REVIEW
Tristan Barrett, Maarten de Rooij, Francesco Giganti, Clare Allen, Jelle O Barentsz, Anwar R Padhani
Multiparametric MRI of the prostate is now recommended as the initial diagnostic test for men presenting with suspected prostate cancer, with a negative MRI enabling safe avoidance of biopsy and a positive result enabling MRI-directed sampling of lesions. The diagnostic pathway consists of several steps, from initial patient presentation and preparation to performing and interpreting MRI, communicating the imaging findings, outlining the prostate and intra-prostatic target lesions, performing the biopsy and assessing the cores...
January 2023: Nature Reviews. Urology
#38
EDITORIAL
Anwar R Padhani, Steven S Raman, Ivo G Schoots
No abstract text is available yet for this article.
September 8, 2022: European Radiology
#39
JOURNAL ARTICLE
Kelsey L Pomykala, Ken Herrmann, Anwar R Padhani, Michael S Hofman, Elisabetta Lalumera, Stefano Fanti
No abstract text is available yet for this article.
June 9, 2022: Journal of Nuclear Medicine
#40
JOURNAL ARTICLE
David Eldred-Evans, Paula Burak, Natalia Klimowska-Nassar, Henry Tam, Heminder Sokhi, Anwar R Padhani, Martin Connor, Derek Price, Martin Gammon, Emily Day, Francesca Fiorentino, Mathias Winkler, Hashim U Ahmed
BACKGROUND AND OBJECTIVES: Prostate cancer screening studies has previously not been able to reflect a diverse group of participants. We evaluated a range of recruitment strategies and their ability to recruit from the Black population and areas of deprivation. METHODS: IP1-PROSTAGRAM was a prospective, population-based, paired screening study of 408 participants conducted at seven UK primary care practices and two imaging centres. All participants underwent screening with a prostate specific antigen (PSA) test, magnetic resonance imaging (MRI), and transrectal ultrasound...
May 30, 2022: Journal of Clinical Epidemiology
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