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James P B O'Connor, Eric O Aboagye, Judith E Adams, Hugo J W L Aerts, Sally F Barrington, Ambros J Beer, Ronald Boellaard, Sarah E Bohndiek, Michael Brady, Gina Brown, David L Buckley, Thomas L Chenevert, Laurence P Clarke, Sandra Collette, Gary J Cook, Nandita M deSouza, John C Dickson, Caroline Dive, Jeffrey L Evelhoch, Corinne Faivre-Finn, Ferdia A Gallagher, Fiona J Gilbert, Robert J Gillies, Vicky Goh, John R Griffiths, Ashley M Groves, Steve Halligan, Adrian L Harris, David J Hawkes, Otto S Hoekstra, Erich P Huang, Brian F Hutton, Edward F Jackson, Gordon C Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O Leach, Ting-Yim Lee, Edward L Leen, Jason S Lewis, Yan Liu, Mark F Lythgoe, Prakash Manoharan, Ross J Maxwell, Kenneth A Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R Padhani, Geoff J M Parker, Mike Partridge, Arvind P Pathak, Andrew C Peet, Shonit Punwani, Andrew R Reynolds, Simon P Robinson, Lalitha K Shankar, Ricky A Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C Sullivan, Stuart A Taylor, Paul S Tofts, Gillian M Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J Williams, Paul Workman, Thomas E Yankeelov, Kevin M Brindle, Lisa M McShane, Alan Jackson, John C Waterton
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification...
October 11, 2016: Nature Reviews. Clinical Oncology
Shaveta Mehta, Nick P Hughes, Sonia Li, Adrian Jubb, Rosie Adams, Simon Lord, Lefteris Koumakis, Ruud van Stiphout, Anwar Padhani, Andreas Makris, Francesca M Buffa, Adrian L Harris
Anti-VEGF antibody bevacizumab has prolonged progression-free survival in several cancer types, however acquired resistance is common. Adaption has been observed pre-clinically, but no human study has shown timing and genes involved, enabling formulation of new clinical paradigms. In a window-of-opportunity study in 35 ductal breast cancer patients for 2weeks prior to neoadjuvant chemotherapy, we monitored bevacizumab response by Dynamic Contrast-Enhanced Magnetic Resonance [DCE-MRI], transcriptomic and pathology...
August 2016: EBioMedicine
Caroline M Moore, Francesco Giganti, Peter Albertsen, Clare Allen, Chris Bangma, Alberto Briganti, Peter Carroll, Masoom Haider, Veeru Kasivisvanathan, Alex Kirkham, Laurence Klotz, Adil Ouzzane, Anwar R Padhani, Valeria Panebianco, Peter Pinto, Philippe Puech, Antti Rannikko, Raphaele Renard-Penna, Karim Touijera, Baris Turkbey, Heinrik van Poppel, Riccardo Valdagni, Jochen Walz, Ivo Schoots
BACKGROUND: Published data on prostate magnetic resonance imaging (MRI) during follow-up of men on active surveillance are lacking. Current guidelines for prostate MRI reporting concentrate on prostate cancer (PCa) detection and staging. A standardised approach to prostate MRI reporting for active surveillance will facilitate the robust collection of evidence in this newly developing area. OBJECTIVE: To develop preliminary recommendations for reporting of individual MRI studies in men on active surveillance and for researchers reporting the outcomes of cohorts of men having MRI on active surveillance...
June 24, 2016: European Urology
Anwar R Padhani, Frederic E Lecouvet, Nina Tunariu, Dow-Mu Koh, Frederik De Keyzer, David J Collins, Evis Sala, Heinz Peter Schlemmer, Giuseppe Petralia, H Alberto Vargas, Stefano Fanti, H Bertrand Tombal, Johann de Bono
CONTEXT: Comparative reviews of whole-body magnetic resonance imaging (WB-MRI) and positron emission tomography/computed tomography (CT; with different radiotracers) have shown that metastasis detection in advanced cancers is more accurate than with currently used CT and bone scans. However, the ability of WB-MRI and positron emission tomography/CT to assess therapeutic benefits has not been comprehensively evaluated. There is also considerable variability in the availability and quality of WB-MRI, which is an impediment to clinical development...
June 14, 2016: European Urology
Ahmed Larbi, Benjamin Dallaudière, Vasiliki Pasoglou, Anwar Padhani, Nicolas Michoux, Bruno C Vande Berg, Bertrand Tombal, Frédéric E Lecouvet
OBJECTIVES: To determine the proportion of prostate cancer (PCa) patients with oligometastatic disease (≤3 synchronous lesions) using whole body magnetic resonance imaging with diffusion-weighted imaging (WB-MRI/DWI). To determine the proportion of patients with nodal disease confined within currently accepted target areas for extended lymph node dissection (eLND) and pelvic external beam radiation therapy (EBRT). SUBJECTS AND METHODS: Two radiologists reviewed WB-MRI/DWI studies in 96 consecutive newly diagnosed metastatic PCa patients; 46 patients with newly diagnosed castration naive PCa (mHNPC) and 50 patients with first appearance of metastasis during monitoring for non-metastatic castration resistant PCa (M0 to mCRPC)...
August 2016: Prostate
David K Woolf, N Jane Taylor, Andreas Makris, Nina Tunariu, David J Collins, Sonia P Li, Mei-Lin Ah-See, Mark Beresford, Anwar R Padhani
OBJECTIVE: To evaluate the performance of six models of population arterial input function (AIF) in the setting of primary breast cancer and neoadjuvant chemotherapy (NAC). The ability to fit patient dynamic contrast-enhanced MRI (DCE-MRI) data, provide physiological plausible data and detect pathological response was assessed. METHODS: Quantitative DCE-MRI parameters were calculated for 27 patients at baseline and after 2 cycles of NAC for 6 AIFs. Pathological complete response detection was compared with change in these parameters from a reproduction cohort of 12 patients using the Bland-Altman approach and receiver-operating characteristic analysis...
July 2016: British Journal of Radiology
S Gillessen, A Omlin, G Attard, J S de Bono, E Efstathiou, K Fizazi, S Halabi, P S Nelson, O Sartor, M R Smith, H R Soule, H Akaza, T M Beer, H Beltran, A M Chinnaiyan, G Daugaard, I D Davis, M De Santis, C G Drake, R A Eeles, S Fanti, M E Gleave, A Heidenreich, M Hussain, N D James, F E Lecouvet, C J Logothetis, K Mastris, S Nilsson, W K Oh, D Olmos, A R Padhani, C Parker, M A Rubin, J A Schalken, H I Scher, A Sella, N D Shore, E J Small, C N Sternberg, H Suzuki, C J Sweeney, I F Tannock, B Tombal
No abstract text is available yet for this article.
May 2, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Roberto García-Figueiras, Sandra Baleato-González, Anwar R Padhani, Ana Marhuenda, Antonio Luna, Lidia Alcalá, Ana Carballo-Castro, Ana Álvarez-Castro
UNLABELLED: Imaging techniques play a key role in the management of patients with colorectal cancer. The introduction of new advanced anatomical, functional, and molecular imaging techniques may improve the assessment of diagnosis, prognosis, planning therapy, and assessment of response to treatment of these patients. Functional and molecular imaging techniques in clinical practice may allow the assessment of tumour-specific characteristics and tumour heterogeneity. This paper will review recent developments in imaging technologies and the evolving roles for these techniques in colorectal cancer...
June 2016: Insights Into Imaging
Matthew D Blackledge, Nina Tunariu, Matthew R Orton, Anwar R Padhani, David J Collins, Martin O Leach, Dow-Mu Koh
Quantitative whole-body diffusion-weighted MRI (WB-DWI) is now possible using semi-automatic segmentation techniques. The method enables whole-body estimates of global Apparent Diffusion Coefficient (gADC) and total Diffusion Volume (tDV), both of which have demonstrated considerable utility for assessing treatment response in patients with bone metastases from primary prostate and breast cancers. Here we investigate the agreement (inter-observer repeatability) between two radiologists in their definition of Volumes Of Interest (VOIs) and subsequent assessment of tDV and gADC on an exploratory patient cohort of nine...
2016: PloS One
Bachir Taouli, Ambros J Beer, Thomas Chenevert, David Collins, Constance Lehman, Celso Matos, Anwar R Padhani, Andrew B Rosenkrantz, Amita Shukla-Dave, Eric Sigmund, Lawrence Tanenbaum, Harriet Thoeny, Isabelle Thomassin-Naggara, Sebastiano Barbieri, Idoia Corcuera-Solano, Matthew Orton, Savannah C Partridge, Dow-Mu Koh
The significant advances in magnetic resonance imaging (MRI) hardware and software, sequence design, and postprocessing methods have made diffusion-weighted imaging (DWI) an important part of body MRI protocols and have fueled extensive research on quantitative diffusion outside the brain, particularly in the oncologic setting. In this review, we summarize the most up-to-date information on DWI acquisition and clinical applications outside the brain, as discussed in an ISMRM-sponsored symposium held in April 2015...
September 2016: Journal of Magnetic Resonance Imaging: JMRI
Roberto García-Figueiras, Sandra Baleato-González, Anwar R Padhani, Laura Oleaga, Joan C Vilanova, Antonio Luna, Juan Carlos Cobas Gómez
Abnormal metabolism is a key tumor hallmark. Proton magnetic resonance spectroscopy (1H-MRS) allows measurement of metabolite concentration that can be utilized to characterize tumor metabolic changes. 1H-MRS measurements of specific metabolites have been implemented in the clinic. This article performs a systematic review of image acquisition and interpretation of 1H-MRS for cancer evaluation, evaluates its strengths and limitations, and correlates metabolite peaks at 1H-MRS with diagnostic and prognostic parameters of cancer in different tumor types...
January 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Roberto García-Figueiras, Anwar R Padhani, Sandra Baleato-González
Cancer therapy is mainly based on different combinations of surgery, radiotherapy, and chemotherapy. Additionally, targeted therapies (designed to disrupt specific tumor hallmarks, such as angiogenesis, metabolism, proliferation, invasiveness, and immune evasion), hormonotherapy, immunotherapy, and interventional techniques have emerged as alternative oncologic treatments. Conventional imaging techniques and current response criteria do not always provide the necessary information regarding therapy success particularly to targeted therapies...
February 2016: Magnetic Resonance Imaging Clinics of North America
Jelle O Barentsz, Jeffrey C Weinreb, Sadhna Verma, Harriet C Thoeny, Clare M Tempany, Faina Shtern, Anwar R Padhani, Daniel Margolis, Katarzyna J Macura, Masoom A Haider, Francois Cornud, Peter L Choyke
No abstract text is available yet for this article.
January 2016: European Urology
Anwar R Padhani, Giuseppe Petralia, Francesco Sanguedolce
MRI directed prostate biopsy will change the cancer risk profiles of diagnosed patients, towards those requiring radical treatments. Increased costs can be balanced by improvements in the efficiency of the patient pathway. Effective communication of imaging findings and improved urological understanding of imaging limitations will improve the quality of care for prostate cancer patients.
January 2016: European Urology
Anwar R Padhani, Giuseppe Petralia, Francesco Sanguedolce
No abstract text is available yet for this article.
August 2016: European Urology
Andrew B Rosenkrantz, Anwar R Padhani, Thomas L Chenevert, Dow-Mu Koh, Frederik De Keyzer, Bachir Taouli, Denis Le Bihan
Technologic advances enable performance of diffusion-weighted imaging (DWI) at ultrahigh b-values, where standard monoexponential model analysis may not apply. Rather, non-Gaussian water diffusion properties emerge, which in cellular tissues are, in part, influenced by the intracellular environment that is not well evaluated by conventional DWI. The novel technique, diffusion kurtosis imaging (DKI), enables characterization of non-Gaussian water diffusion behavior. More advanced mathematical curve fitting of the signal intensity decay curve using the DKI model provides an additional parameter Kapp that presumably reflects heterogeneity and irregularity of cellular microstructure, as well as the amount of interfaces within cellular tissues...
November 2015: Journal of Magnetic Resonance Imaging: JMRI
David K Woolf, Anwar R Padhani, Andreas Makris
The use of imaging in the arena of primary treatment for breast cancer is gaining importance as a technique for assessing response to chemotherapy as well as assessing the underlying tumor biology. Both mammography and ultrasound have traditionally been used, in addition to clinical evaluation, to evaluate response to treatment although they have shed little light on the underlying biological processes. Functional magnetic resonance imaging techniques have the ability to assess response to treatments in addition to providing valuable information on changes in tumor perfusion, vascular permeability, oxygenation, cellularity, proliferation, and metabolism both at baseline and after treatment...
May 2015: Journal of the National Cancer Institute. Monographs
S Gillessen, A Omlin, G Attard, J S de Bono, E Efstathiou, K Fizazi, S Halabi, P S Nelson, O Sartor, M R Smith, H R Soule, H Akaza, T M Beer, H Beltran, A M Chinnaiyan, G Daugaard, I D Davis, M De Santis, C G Drake, R A Eeles, S Fanti, M E Gleave, A Heidenreich, M Hussain, N D James, F E Lecouvet, C J Logothetis, K Mastris, S Nilsson, W K Oh, D Olmos, A R Padhani, C Parker, M A Rubin, J A Schalken, H I Scher, A Sella, N D Shore, E J Small, C N Sternberg, H Suzuki, C J Sweeney, I F Tannock, B Tombal
The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection...
August 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Roberto García-Figueiras, Anwar R Padhani, Ambros J Beer, Sandra Baleato-González, Joan C Vilanova, Antonio Luna, Laura Oleaga, Antonio Gómez-Caamaño, Dow-Mu Koh
Angiogenesis is a key cancer hallmark involved in tumor growth and metastasis development. Angiogenesis and tumor microenvironment significantly influence the response of tumors to therapies. Imaging techniques have changed our understanding of the process of angiogenesis, the resulting vascular performance, and the tumor microenvironment. This article reviews the status and potential clinical value of the imaging modalities used to assess the status of tumor vasculature in vivo, before, during, and after treatment...
September 2015: Current Problems in Diagnostic Radiology
Chooi Peng Lee, N Jane Taylor, Gerhardt Attard, Simon Pacey, Paul D Nathan, Johann S de Bono, Graham Temple, Susan Bell, Martin Stefanic, Peter Stopfer, Adrian Tang, Dow-Mu Koh, David J Collins, James d'Arcy, Anwar R Padhani, Martin O Leach, Ian R Judson, Gordon J Rustin
BACKGROUND: This open-label phase I dose-escalation study investigated the safety, efficacy, pharmacokinetics (PK), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) effects of the oral angiokinase inhibitor nintedanib in patients with advanced solid tumors. METHODS: Nintedanib was administered once daily continuously, starting at 100 mg and later amended to allow evaluation of 250 mg b.i.d. The primary endpoint was maximum tolerated dose (MTD)...
April 2015: Oncologist
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