Pallavi Galera, Deepika Dilip, Andriy Derkach, Alexander Chan, Yanming Zhang, Sonali Persuad, Tanmay Mishera, Ying Liu, Christopher Famulare, Qi Gao, Douglas A Mata, Maria Arcila, Mark B Geyer, Eytan Stein, Ahmet Dogan, Ross L Levine, Mikhail Roshal, Jacob Glass, Wenbin Xiao
UNLABELLED: Mixed phenotype (MP) in acute leukemias poses unique classification and management dilemmas and can be seen in entities other than de novo mixed phenotype acute leukemia (MPAL). Although WHO classification empirically recommends excluding AML with myelodysplasia related changes (AML-MRC) and therapy related AML (t-AML) with mixed phenotype (AML-MP) from MPAL, there is lack of studies investigating the clinical, genetic, and biologic features of AML-MP. We report the first cohort of AML-MRC and t-AML with MP integrating their clinical, immunophenotypic, genomic and transcriptomic features with comparison to MPAL and AML-MRC/t-AML without MP...
November 3, 2023: medRxiv