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https://www.readbyqxmd.com/read/27936379/clinical-and-epidemiological-characteristics-associated-with-unfavorable-tuberculosis-treatment-outcomes-in-tb-hiv-co-infected-patients-in-brazil-a-hierarchical-polytomous-analysis
#1
Thiago Nascimento do Prado, Jayant V Rajan, Angélica Espinosa Miranda, Elias Dos Santos Dias, Lorrayne Beliqui Cosme, Lia Gonçalves Possuelo, Mauro N Sanchez, Jonathan E Golub, Lee W Riley, Ethel Leonor Maciel
BACKGROUND: TB patients co-infected with HIV have worse treatment outcomes than non-coinfected patients. How clinical characteristics of TB and socioeconomic characteristics influence these outcomes is poorly understood. Here, we use polytomous regression analysis to identify clinical and epidemiological characteristics associated with unfavorable treatment outcomes among TB-HIV co-infected patients in Brazil. METHODS: TB-HIV cases reported in the Brazilian information system (SINAN) between January 1, 2001 and December 31, 2011 were identified and categorized by TB treatment outcome (cure, default, death, and development of MDR TB)...
December 6, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27936146/performance-of-clinical-screening-algorithms-for-tuberculosis-intensified-case-finding-among-people-living-with-hiv-in-western-kenya
#2
Surbhi Modi, Joseph S Cavanaugh, Ray W Shiraishi, Heather L Alexander, Kimberly D McCarthy, Barbara Burmen, Hellen Muttai, Chad M Heilig, Allyn K Nakashima, Kevin P Cain
OBJECTIVE: To assess the performance of symptom-based screening for tuberculosis (TB), alone and with chest radiography among people living with HIV (PLHIV), including pregnant women, in Western Kenya. DESIGN: Prospective cohort study. METHODS: PLHIV from 15 randomly-selected HIV clinics were screened with three clinical algorithms [World Health Organization (WHO), Ministry of Health (MOH), and "Improving Diagnosis of TB in HIV-infected persons" (ID-TB/HIV) study], underwent chest radiography (unless pregnant), and provided two or more sputum specimens for smear microscopy, liquid culture, and Xpert MTB/RIF...
2016: PloS One
https://www.readbyqxmd.com/read/27935650/association-between-diabetes-mellitus-and-active-tuberculosis-in-africa-and-the-effect-of-hiv
#3
REVIEW
Sarah Lou Bailey, Helen Ayles
OBJECTIVE: To determine current evidence for the association between diabetes and active tuberculosis in Africa, and how HIV modifies, or not, any association between diabetes and active tuberculosis. METHODS: We conducted a systematic review by searching the EMBASE, Global Health and Medline databases. Studies were eligible for inclusion if they explored the association between diabetes mellitus prevalence and active tuberculosis incidence or prevalence, used a comparison group, were conducted in an African population and adjusted the analysis for at least age...
December 9, 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27932622/inflammasome-activation-underlies-central-nervous-system-deterioration-in-hiv-associated-tuberculosis
#4
Suzaan Marais, Rachel P J Lai, Katalin A Wilkinson, Graeme Meintjes, Anne O'Garra, Robert J Wilkinson
Tuberculosis meningitis (TBM) is a frequent cause of meningitis in HIV-infected individuals, resulting in death in ~ 40% of affected patients. A severe complication of antiretroviral therapy (ART) in these patients is neurological TB-immune reconstitution inflammatory syndrome (IRIS), but its underlying cause remains poorly understood. To investigate the pathogenesis of TBM-IRIS, we performed longitudinal whole blood microarray analysis of HIV-infected TBM patients and reflected the findings at the protein level...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27931691/risk-assessment-of-hepatotoxicity-among-tuberculosis-and-human-immunodeficiency-virus-aids-coinfected-patients-under-tuberculosis-treatment
#5
Williams Ngouleun, Prosper Cabral Biapa Nya, Anatole Constant Pieme, Phelix Bruno Telefo
OBJECTIVE/BACKGROUND: Tuberculosis (TB) is a worldwide public health problem. It is a contagious and grave disease caused by Mycobacterium tuberculosis. Current drugs such as isoniazid, pyrazinamide, and rifampicin used for the treatment of tuberculosis are potentially hepatotoxic and can lead to drug hepatitis. In order to improve the follow-up of TB patients in Cameroon, we carried out a study which aimed to evaluate the hepatotoxicity risk factors associated with anti-TB drugs. METHODS: The studies were performed on 75 participants who had visited the Loum District Hospital located in the littoral region of Cameroon for their routine consultation...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931678/diagnosing-tuberculosis-in-the-21st-century-dawn-of-a-genomics-revolution
#6
REVIEW
Christopher Jeanes, Justin O'Grady
Tuberculosis (TB) ranks alongside HIV as the leading cause of death worldwide, killing 1.5million people in 2014. Traditional laboratory techniques do not provide sufficiently rapid results to inform clinicians on appropriate treatment, especially in the face of increasingly prevalent drug-resistant TB. Rapid molecular methods such as PCR and LAMP are vital tools in the fight against TB, however, rapid advances in next generation sequencing (NGS) technology are allowing increasingly rapid and accurate sequencing of entire bacterial genomes at ever decreasing cost, providing unprecedented depth of information...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931339/mobility-patterns-of-persons-at-risk-for-drug-resistant-tuberculosis-in-mumbai-india
#7
E Conners, R S Garfein, T C Rodwell, Z F Udwadia, D G Catanzaro
SETTING: Tuberculosis (TB) hospital in Mumbai, India. OBJECTIVE: To describe the mobility patterns of persons with suspected drug-resistant tuberculosis (DR-TB) and to assess whether there were significant differences in demographic or risk characteristics based on mobility. DESIGN: Observational cohort study of TB clinic patients at risk for DR-TB. RESULTS: Among 602 participants, 37% had ever moved from their place of birth; 14% were local movers (within state), and 23% were distant movers, between states or countries...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931336/risk-of-tuberculosis-during-pregnancy-in-mongolia-a-high-incidence-setting-with-low-hiv-prevalence
#8
N L Rendell, N Batjargal, N Jadambaa, C C Dobler
OBJECTIVE: To investigate the epidemiology and the relative risk of tuberculosis (TB) in pregnant women in Mongolia, a high TB incidence setting with a low rate of human immunodeficiency virus co-infection, where active case finding for TB in pregnancy is implemented. DESIGN: We retrospectively collected data on pregnant women diagnosed with TB during 2013. Data were collected through doctors at central TB dispensaries who extracted the relevant information from patients' clinical records...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931335/clinical-characteristics-and-outcomes-of-tuberculosis-in-douala-cameroon-a-7-year-retrospective-cohort-study
#9
B H Mbatchou Ngahane, F Dahirou, C Tchieche, A Wandji, C Ngni, A Nana-Metchedjin, E Nyankiy, M L Endale Mangamba, C Kuaban
SETTING: Tuberculosis (TB) clinic, Douala Laquintinie Hospital, Douala, Cameroon. OBJECTIVE: To describe the clinical characteristics of TB and to investigate predictors of poor treatment outcomes. DESIGN: A registry-based, retrospective cohort study of all TB cases recorded from 2007 to 2013 was conducted. Multinomial logistic regression models were used to identify predictors of poor outcomes. RESULTS: Of 8902 TB cases included, 5110 (57...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931330/policies-and-practices-on-the-programmatic-management-of-latent-tuberculous-infection-global-survey
#10
Y Hamada, A Sidibe, A Matteelli, A Dadu, M A Aziz, M Del Granado, N Nishikiori, K Floyd, H Getahun
SETTING: Global survey among low tuberculosis (TB) burden countries, which are primary target countries for the World Health Organization (WHO) guidelines on the programmatic management of latent tuberculous infection (LTBI). OBJECTIVE: To perform a baseline assessment of policies and practices for the programmatic management of LTBI. DESIGN: Online and paper-based pre-tested questionnaire filled out by national TB programme managers or their equivalents from 108 countries...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931328/the-contributions-of-steve-lawn-to-the-science-advocacy-and-policy-of-hiv-associated-tb
#11
Annelies Van Rie, Ted Cohen
No abstract text is available yet for this article.
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931232/retention-in-georgia-opioid-substitution-therapy-program-and-associated-factors
#12
Ekaterine Ruadze, Khatuna Todadze
BACKGROUND: Substance abuse has been considered as a growing challenge in Georgia that is closely linked with human immune deficiency virus (HIV) and hepatitis C transmission due to unsafe injection and other uncontrolled behaviors. Methadone maintenance therapy is one of the major treatment options for opioid-dependent individuals. It has proven efficacy in decreasing illegal opioid consumption and criminal behavior as well as reducing the level of HIV infection, mortality, HCV infection, and increasing social functioning...
December 8, 2016: Harm Reduction Journal
https://www.readbyqxmd.com/read/27930610/using-mhealth-for-hiv-tb-treatment-support-in-lesotho-enhancing-patient-provider-communication-in-the-start-study
#13
Yael Hirsch-Moverman, Amrita Daftary, Katharine A Yuengling, Suzue Saito, Moeketsi Ntoane, Koen Frederix, Llang B Maama, Andrea A Howard
BACKGROUND: mHealth is a promising means of supporting adherence to treatment. The Start TB patients on ART and Retain on Treatment (START) study included real-time adherence support using short-text messaging service (SMS) text messaging and trained village health workers (VHWs). We describe the use and acceptability of mHealth by patients with HIV/tuberculosis and health care providers. METHODS: Patients and treatment supporters received automated, coded medication and appointment reminders at their preferred time and frequency, using their own phones, and $3...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27928093/imported-disease-screening-prior-to-chemotherapy-and-bone-marrow-transplantation-for-oncohematological-malignancies
#14
Adrián Sánchez-Montalvá, Fernando Salvador, Isabel Ruiz-Camps, Pere Barba, David Valcárcel, Elena Sulleiro, Enrique Sanz-García, Israel Molina
Reactivation of latent imported infections has been periodically reported in migrant patients undergoing immunosuppression. We performed a prospective study at Vall d'Hebron University Hospital (Barcelona, Spain). Migrant patients over 16 years with the diagnosis of any oncohematologic disease were included. Patients were tested for soil-transmitted helminths, hepatitis virus, and human immunodeficiency virus, Treponema pallidum, human T-cell lymphotropic virus, latent tuberculosis infection, Toxoplasma spp...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27928075/detecting-mutations-in-the-mycobacterium-tuberculosis-pyrazinamidase-gene-pnca-to-improve-infection-control-and-decrease-drug-resistance-rates-in-human-immunodeficiency-virus-coinfection
#15
Matthew Z Dudley, Patricia Sheen, Robert H Gilman, Eduardo Ticona, Jon S Friedland, Daniela E Kirwan, Luz Caviedes, Richard Rodriguez, Lilia Z Cabrera, Jorge Coronel, Louis Grandjean, David A J Moore, Carlton A Evans, Luz Huaroto, Víctor Chávez-Pérez, Mirko Zimic
Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA) is a potent drug that effectively sterilizes persistent Mycobacterium tuberculosis bacilli. However, PZA resistance associated with mutations in the nicotinamidase/pyrazinamidase coding gene, pncA, is increasing. A total of 794 patient isolates obtained from four sites in Lima, Peru, underwent spoligotyping and drug resistance testing...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27927856/the-long-term-mortality-of-tuberculosis-meningitis-patients-in-new-york-city-a-cohort-study
#16
Christopher Vinnard, Liza King, Sonal Munsiff, Aldo Crossa, Kentaro Iwata, Jotam Pasipanodya, Douglas Proops, Shama Ahuja
BACKGROUND: Tuberculosis meningitis (TBM) is the most devastating clinical presentation of infection with M. tuberculosis; delayed initiation of effective anti-tuberculosis (TB) therapy is associated with poor treatment outcomes. Our objective was to determine the relationship between drug resistance and 10-year mortality among TBM patients. METHODS: We conducted a retrospective cohort study of 324 patients with culture-confirmed TBM, susceptibility results reported for isoniazid and rifampin, and initiation of at least two anti-TB drugs, reported to the TB registry in New York City, NY (US) between January 1, 1992 and December 31, 2001...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927247/frequency-and-distribution-patterns-of-opportunistic-infections-associated-with-hiv-aids-in-uganda
#17
John Rubaihayo, Nazarius M Tumwesigye, Joseph Konde-Lule, Henry Wamani, Edith Nakku-Joloba, Fredrick Makumbi
BACKGROUND: We conducted a study to assess the frequency and distribution patterns of selected opportunistic infections (OIs) and opportunistic cancers (OCs) in different geographical areas before and after HAART in Uganda. METHODS: This was a cross-sectional serial review of observation data for adult HIV positive patients (≥15 years) enrolled with the AIDS support organization (TASO) in Uganda covering the period from January 2001 to December 2013. Both AIDS defining OIs/OCs and non-AIDS defining OIs were analyzed...
December 7, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27923012/using-mhealth-for-hiv-tb-treatment-support-in-lesotho-enhancing-patient-provider-communication-in-the-start-study
#18
Yael Hirsch-Moverman, Amrita Daftary, Katharine A Yuengling, Suzue Saito, Moeketsi Ntoane, Koen Frederix, Llang B Maama, Andrea A Howard
BACKGROUND: mHealth is a promising means of supporting adherence to treatment. The Start TB patients on ART and Retain on Treatment (START) study included real-time adherence support using short-text messaging service (SMS) text messaging and trained village health workers (VHWs). We describe the use and acceptability of mHealth by patients with HIV/tuberculosis and health care providers. METHODS: Patients and treatment supporters received automated, coded medication and appointment reminders at their preferred time and frequency, using their own phones, and $3...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27921633/healthcare-resources-are-inadequate-to-address-the-burden-of-illness-among-hiv-infected-male-prisoners-in-malaysia
#19
Joseph Bick, Gabriel Culbert, Haider A Al-Darraji, Clayton Koh, Veena Pillai, Adeeba Kamarulzaman, Frederick Altice
Purpose Criminalization of drug use in Malaysia has concentrated people who inject drugs (PWID) and people living with HIV into prisons where health services are minimal and HIV-related mortality is high. Few studies have comprehensively assessed the complex health needs of this population. The paper aims to discuss these issues. Design/methodology/approach From October 2012 through March 2013, 221 sequentially selected HIV-infected male prisoners underwent a comprehensive health assessment that included a structured history, physical examination, and clinically indicated diagnostic studies...
December 19, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27917197/profile-and-treatment-outcomes-of-patients-with-tuberculosis-in-northeastern-ethiopia-a-cross-sectional-study
#20
Daniel Mekonnen, Awoke Derbie, Hailu Mekonnen, Yohannes Zenebe
BACKGROUND: Data on the epidemiology of tuberculosis and its treatment outcomes were incomplete in the study area and this study was done to fill this gap. METHODS: Institution based cross sectional study was conducted from January 2011 to December 2014. A total of 949 TB patients who were on treatment in North Eastern Ethiopia, Eastern Amhara region were included. Data was analyzed using SPSS version 20. Frequency, percentages and means were used to present data...
September 2016: African Health Sciences
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