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miR-218

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https://www.readbyqxmd.com/read/29751935/down-regulation-of-mir-218-5p-promotes-apoptosis-of-human-umbilical-vein-endothelial-cells-through-regulating-high-mobility-group-box-1-in-henoch-schonlein-purpura
#1
Shao-Fei Yu, Wan-Yu Feng, Shao-Qing Chai, Xiao-Bo Meng, Zhong-Xia Dou, Hua Zhu
BACKGROUND: Apoptosis of human umbilical vein endothelial cells (HUVECs) plays an important role in the progression of Henoch-Schonlein purpura (HSP). In the present study, we explored the function of miR-218-5p in HUVEC apoptosis and HSP development. MATERIALS AND METHODS: HSP rat model was established and peripheral blood mononuclear cells (PBMC) were isolated. The expression of miR-218-5p and high-mobility group box-1 (HMGB1) protein in HUVECs was determined by quantitative real-time polymerase chain reaction and western blot, respectively...
April 5, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29717030/lack-of-association-between-mir-218-rs11134527-a-g-and-kawasaki-disease-susceptibility
#2
Lei Pi, Lanyan Fu, Yufen Xu, Di Che, Qiulian Deng, Xijing Huang, Meiai Li, Li Zhang, Ping Huang, Xiaoqiong Gu
Abstract Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least five days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is associated with susceptibility to various cancer risks. However, there is a lack of evidence regarding the relationship between this polymorphism and KD risk. This study explored the correlation between the miR-218 rs11134527 A>G polymorphism and the risk of KD...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29693114/human-circular-rna%C3%A2-0054633-regulates-high-glucose%C3%A2-induced-vascular-endothelial-cell-dysfunction-through-the-microrna%C3%A2-218-roundabout-1-and-microrna%C3%A2-218-heme-oxygenase%C3%A2-1-axes
#3
Long Pan, Weishuai Lian, Xiaojun Zhang, Shilong Han, Chuanwu Cao, Xue Li, Maoquan Li
The aim of the present study was to investigate the relative regulation of human circular RNA‑0054633 (hsa_circ_0054633), microRNA‑218 (miR‑218), roundabout 1 (ROBO1) and heme oxygenase‑1 (HO‑1) in human umbilical vein endothelial cells (HUVECs) in high glucose conditions. Initially, the expression of hsa_circ_0054633 in HUVECs was detected in high glucose conditions by reverse transcription‑quantitative polymerase chain reaction. Next, a small interfering RNA against hsa_circ_0054633 was constructed to investigate the function of jsa_circ_0054633 in HUVECs by transwell migration, cell counting kit‑8, flow cytometry and tube formation assays...
April 16, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29692628/the-association-of-polymorphisms-in-mirnas-with-nonsmall-cell-lung-cancer-in-a-han-chinese-population
#4
Chuanyin Li, Yu Zhang, Yingfu Li, Qianli Ma, Shuyuan Liu, Yueting Yao, Fang Tan, Li Shi, Yufeng Yao
Background: MicroRNAs (miRNAs) have been demonstrated to play important roles in cancer progression. Recently, studies have revealed that polymorphisms in miRNAs might be associated with cancer susceptibility. Materials and methods: In the current study, we investigated the associations of single nucleotide polymorphisms (SNPs) in miRNAs (rs11134527 in pri-miR-218-2 , rs74693964 in pri-miR-145 , rs6062251 in pri-miR-133a-2 , and rs4705343 in pri-miR-143 ) with nonsmall cell lung cancer (NSCLC) in a Han population from Yunnan Province, Southwest China using a binary logistic regression analysis...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29566346/emerging-role-of-extracellular-vesicles-in-bone-remodeling
#5
M Liu, Y Sun, Q Zhang
Extracellular vesicles (EVs), as nanometer-scale particles, include exosomes, microvesicles, and apoptotic bodies. EVs are released by most cell types, such as bone marrow stem cells, osteoblasts, osteoclasts, and immune cells. In bone-remodeling microenvironments, EVs deliver specific proteins (e.g., tenascin C and Sema4D), microRNAs (e.g., miR-214-3p, miR-183-5p, and miR-196a), and other growth factors (e.g., bone morphogenetic protein 1 to 7 and transforming growth factor β1) to osteoblasts and regulate bone formation...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29542383/predisposition-of-six-well-characterized-micrornas-to-syndesmophytes-among-chinese-patients-with-ankylosing-spondylitis
#6
Wenxue Yang, Xiaoping Yan, Qisheng Xia, Qingwen Tao, Xiaowei Gan, Yingze Zhang, Zhihua Chen, Weiping Kong
OBJECTIVES: We quantified the expression of six well-characterized microRNAs (miRNAs) in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients. METHODS: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. miRNAs expression was quantified by real-time PCR. RESULTS: Six examined miRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p > ...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29523928/microrna-218-promotes-osteogenic-differentiation-of-mesenchymal-stem-cells-and-accelerates-bone-fracture-healing
#7
Liu Shi, Lu Feng, Yang Liu, Ji-Qiang Duan, Wei-Ping Lin, Jin-Fang Zhang, Gang Li
As a regulator of osteogenesis, microRNA-218 (miR-218) is reported to promote osteogenesis of mesenchymal stem cells (MSCs). However, the in vivo osteogenic effect of miR-218 remains elusive. In this study, miR-218 was confirmed to promote osteogenic differentiation of MSCs by stimulating the alkaline phosphatase activity, calcium nodule formation, and osteogenic marker gene expression. For in vivo study, the miR-218-overexpressing BMSCs were locally administrated into the fracture sites in a femur fracture mouse model...
March 9, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29516954/heparan-sulfate-d-glucosamine-3-o-sulfotransferase-3b1-is-a-novel-regulator-of-transforming-growth-factor-beta-mediated-epithelial-to-mesenchymal-transition-and-regulated-by-mir-218-in-nonsmall-cell-lung-cancer
#8
Zengli Zhang, Hanyi Jiang, Yongsheng Wang, Minhua Shi
Background: Due to high metastasis and recurrence rate. Recent studies indicated that epithelial-to-mesenchymal transition (EMT) was involved in the progression and metastasis in cancer. Some reports also indicate that HS3ST3B1 played a role in angiogenesis and the proliferation of cancer cells. In this study, we aim to investigate its role in non-small cell lung cancer (NSCLC) . Materials and Methods: All cell lines were purchased from ATCC and cultured in our central lab...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29456728/values-of-mir-34a-and-mir-218-expression-in-the-diagnosis-of-cervical-cancer-and-the-prediction-of-prognosis
#9
Ping Wang, Guanyun Zhai, Yunyan Bai
The expression levels of microribonucleic acid 34a (miR-34a) and miR-218 in the serum and tumor tissues of patients with cervical cancer were investigated to explore their relationship with the diagnosis of cervical cancer. Fifty patients with cervical cancer were selected, and 30 normal patients were selected as the control group. The expression levels of miR-34a and miR-218 were detected by quantitative real-time polymerase chain reaction. The relationship between the expression of miR-34a and miR-218 was analyzed using Pearson's correlation coefficient, and the receiver operating characteristic (ROC) curve was plotted for the analysis of values of the expression of miR-34a and miR-218...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29378184/mir-218-and-mir-129-regulate-breast-cancer-progression-by-targeting-lamins
#10
Stephanie Rebecca Setijono, Mikyung Park, Goeun Kim, Yongjo Kim, Kae Won Cho, Su Jung Song
Breast cancer is the most frequently diagnosed life-threatening cancer in women. Triple-negative breast cancer (TNBC) has an aggressive clinical behavior, but the treatment of TNBC remains challenging. MicroRNAs (miRNAs) have emerged as a potential target for the diagnosis, therapy and prognosis of breast cancer. However, the precise role of miRNAs and their targets in breast cancer remain to be elucidated. Here we show that miR-218 is downregulated and miR-129 is upregulated in TNBC samples and their expressions confer prognosis to patients...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29344251/mir-218-inhibits-acute-promyelocytic-leukemia-cell-growth-by-targeting-bmi-1
#11
Yan Wang, Hai-Hong Sun, Ming-Hua Sui, Jun-Jie Ma
Acute promyelocytic leukemia (APL) is a subtype of acute myelocytic leukemia. Previous studies have reported a number of functions and therapeutic roles of microRNAs (miRs) in APL, and have suggested that miR-218 acts as a tumor suppressor in a number of types of human cancer; however, its role in APL remains unclear. In the present study, the expression of miR-218 and its effects on the viability and proliferation of HL-60 cells was investigated. Reverse transcription-quantitative polymerase chain reaction analysis demonstrated that miR-218 was frequently downregulated in APL marrow tissues compared with normal marrow tissues...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29317318/association-study-of-mir-100-mir-124-1-mir-218-2-mir-301b-mir-605-and-mir-4293-polymorphisms-and-the-risk-of-breast-cancer-in-a-sample-of-iranian-population
#12
Hiva Danesh, Mohammad Hashemi, Fatemeh Bizhani, Seyed Mehdi Hashemi, Gholamreza Bahari
MicroRNAs (miRNAs) regulate genes expression by directly binding to the 3' untranslated region (3'UTR) of specific target mRNAs. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are proposed to be important in the development of breast cancer (BC). In the present study, we conducted a case-control study with 266 BCE patients and 288 control women to examine the possible association of miRNAs polymorphisms (miR-100 rs1834306, miR-124-1 rs531564, miR-218-2 rs11134527, miR-301b rs384262, miR-605 rs2043556, and miR-4293 rs12220909) with BC susceptibility...
March 20, 2018: Gene
https://www.readbyqxmd.com/read/29304813/the-association-between-pre-mir-27a-rs895819-polymorphism-and-myocardial-infarction-risk-in-a-chinese-han-population
#13
Meng-Yun Cai, Jie Cheng, Meng-Yuan Zhou, Li-Li Liang, Si-Min Lian, Xiao-Shan Xie, Shun Xu, Xinguang Liu, Xing-Dong Xiong
BACKGROUND: Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population...
January 6, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29297241/exosomal-small-rna-sequencing-uncovers-the-microrna-dose-markers-for-power-frequency-electromagnetic-field-exposure
#14
Hualiang Li, Lin Lin, Li Li, Liang Zhou, Ying Zhang, Shuai Hao, Zhenhua Ding
PURPOSE: The potential health risks caused by power frequency electromagnetic field (PFEMF) have led to increase public health concerns. However, the diagnosis and prognosis remain challenging in determination of exact dose of PFEMF exposure. MATERIALS AND METHODS: Mice were exposed to different magnetic doses of PFEMF for the following isolation of serum exosomes, microRNAs (miRNAs) extraction and small RNA sequencing. After small RNA sequencing, bioinformatic analysis, quantitative real-time PCR (qRT-PCR) validation and serum exosomal miRNA biomarkers were determined...
January 11, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29229679/epigenetic-and-posttranscriptional-regulation-of-cd16-expression-during-human-nk-cell-development
#15
Aaron R Victor, Christoph Weigel, Steven D Scoville, Wing Keung Chan, Kelsey Chatman, Mary M Nemer, Charlene Mao, Karen A Young, Jianying Zhang, Jianhua Yu, Aharon G Freud, Christopher C Oakes, Michael A Caligiuri
The surface receptor FcγRIIIA (CD16a) is encoded by the FCGR3A gene and is acquired by human NK cells during maturation. NK cells bind the Fc portion of IgG via CD16a and execute Ab-dependent cell-mediated cytotoxicity, which is critical for the effectiveness of several antitumor mAb therapies. The role of epigenetic regulatory mechanisms controlling transcriptional and posttranscriptional CD16 expression in NK cells is unknown. In this study, we compared specific patterns of DNA methylation and expression of FCGR3A with FCGR3B , which differ in cell type-specific expression despite displaying nearly identical genomic sequences...
January 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29220380/hexokinase-2-hk2-the-tumor-promoter-in-glioma-is-downregulated-by-mir-218-bmi1-pathway
#16
Hui Liu, Nan Liu, Yingduan Cheng, Weilin Jin, Pengxing Zhang, Xin Wang, Hongwei Yang, Xiaoshan Xu, Zhen Wang, Yanyang Tu
In cancer, glycolysis driving enzymes and their regulating microRNAs are one of the key focus of oncology research lately. The glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioma, the most common malignant brain tumor. In the present study, we studied the tumorigenic role of HK2 in glioma, and clarified the mechanism of miR-218 induced HK2 regulation in glioma development. The HK2 expression in patient derived glioma and non neoplastic brain tissue was quantified. The HK2 silenced U87 and U251 cell lines were assessed for their proliferation, migration and invasive potential in vitro, while the tumor forming potential of U87 cells was evaluated in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29218085/identification-and-differential-expression-of-micrornas-in-1-25-dihydroxyvitamin-d3-induced-osteogenic-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#17
Huijie Gu, Jun Xu, Zhongyue Huang, Liang Wu, Kaifeng Zhou, Yiming Zhang, Jiong Chen, Jiangni Xia, Xiaofan Yin
The aim of this study was to identify specific microRNAs (miRNAs) and their regulatory roles in the process of 1, 25-dihydroxyvitamin D3-induced (VD3-induced) osteogenic differentiation of human adipose-derived Mesenchymal stem cells (hAMSCs). The differentially expressed miRNAs in VD3-induced hAMSCs was examined. The putative target genes of these miRNAs were predicted. A total of 76 conserved miRNAs, including 18 miRNAs were significantly up-regulated and 58 miRNAs were significantly downregulated, and significantly differentially expressed between the two samples...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29207663/microrna-218-inhibits-proliferation-and-invasion-in-ovarian-cancer-by-targeting-runx2
#18
Na Li, Lufei Wang, Guangyun Tan, Zhiheng Guo, Lei Liu, Ming Yang, Jin He
MicroRNA-218 (miR-218) has been implicated in the development and progression of multiple cancers. We investigated the role of miR-218 in ovarian cancer progression. We found that miR-218 expression levels were lower in ovarian cancer tissues and cell lines than in adjacent normal tissues or a normal ovarian cell line.miR-218 levels associated with International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis. Exogenous expression of miR-218 inhibited cell proliferation, colony formation, migration, and invasion in vitro and suppressed tumor growth in a tumor-bearing nude mouse model...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29160895/differential-expression-of-micrornas-contributed-to-the-health-efficacy-of-egcg-in-in-vitro-subarachnoid-hemorrhage-model
#19
Ying Chen, Liyong Huang, Lei Wang, Lingyun Chen, Wenhua Ren, Wenke Zhou
(-)-Epigallocatechin-3-gallate (EGCG) exhibits a broader spectrum health efficacy in subarachnoid hemorrhage (SAH) therapy; the mechanisms, however, are largely unknown. Given that miRNAs play important roles in regulation of thousands of gene expressions, the effect of EGCG on the expression of miRNAs was investigated to explore the multi-targeting actions of EGCG by using an in vitro SAH model. MTT and western blot assays were used to assess the health effects of EGCG in SAH progression; the results showed that oxyhemoglobin (OxyHb)-induced cell proliferation and excessive autophagic activation were significantly inhibited by 50 μM EGCG, but not by 1 μM EGCG...
December 13, 2017: Food & Function
https://www.readbyqxmd.com/read/29154364/non-contingent-exposure-to-amphetamine-in-adolescence-recruits-mir-218-to-regulate-dcc-expression-in-the-vta
#20
Santiago Cuesta, José Maria Restrepo-Lozano, Steven Silvestrin, Dominique Nouel, Angélica Torres-Berrío, Lauren M Reynolds, Andreas Arvanitogiannis, Cecilia Flores
The development of the dopamine input to the medial prefrontal cortex occurs during adolescence and is a process that is vulnerable to disruption by stimulant drugs such as amphetamine. We have previously linked the amphetamine-induced disruption of dopamine connectivity and prefrontal cortex maturation during adolescence to the downregulation of the Netrin-1 receptor, DCC, in dopamine neurons. However, how DCC expression in dopamine neurons is itself regulated is completely unknown. MicroRNA (miRNA) regulation of mRNA translation and stability is a prominent mechanism linking environmental events to changes in protein expression...
March 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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