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miR-218

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https://www.readbyqxmd.com/read/29344251/mir-218-inhibits-acute-promyelocytic-leukemia-cell-growth-by-targeting-bmi-1
#1
Yan Wang, Hai-Hong Sun, Ming-Hua Sui, Jun-Jie Ma
Acute promyelocytic leukemia (APL) is a subtype of acute myelocytic leukemia. Previous studies have reported a number of functions and therapeutic roles of microRNAs (miRs) in APL, and have suggested that miR-218 acts as a tumor suppressor in a number of types of human cancer; however, its role in APL remains unclear. In the present study, the expression of miR-218 and its effects on the viability and proliferation of HL-60 cells was investigated. Reverse transcription-quantitative polymerase chain reaction analysis demonstrated that miR-218 was frequently downregulated in APL marrow tissues compared with normal marrow tissues...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29317318/association-study-of-mir-100-mir-124-1-mir-218-2-mir-301b-mir-605-and-mir-4293-polymorphisms-and-the-risk-of-breast-cancer-in-a-sample-of-iranian-population
#2
Hiva Danesh, Mohammad Hashemi, Fatemeh Bizhani, Seyed Mehdi Hashemi, Gholamreza Bahari
MicroRNAs (miRNAs) regulate genes expression by directly binding to the 3' untranslated region (3'UTR) of specific target mRNAs. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are proposed to be important in the development of breast cancer (BC). In the present study, we conducted a case-control study with 266 BCE patients and 288 control women to examine the possible association of miRNAs polymorphisms (miR-100 rs1834306, miR-124-1 rs531564, miR-218-2 rs11134527, miR-301b rs384262, miR-605 rs2043556, and miR-4293 rs12220909) with BC susceptibility...
January 6, 2018: Gene
https://www.readbyqxmd.com/read/29304813/the-association-between-pre-mir-27a-rs895819-polymorphism-and-myocardial-infarction-risk-in-a-chinese-han-population
#3
Meng-Yun Cai, Jie Cheng, Meng-Yuan Zhou, Li-Li Liang, Si-Min Lian, Xiao-Shan Xie, Shun Xu, Xinguang Liu, Xing-Dong Xiong
BACKGROUND: Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population...
January 6, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29297241/exosomal-small-rna-sequencing-uncovers-the-microrna-dose-markers-for-power-frequency-electromagnetic-field-exposure
#4
Hualiang Li, Lin Lin, Li Li, Liang Zhou, Ying Zhang, Shuai Hao, Zhenhua Ding
PURPOSE: The potential health risks caused by power frequency electromagnetic field (PFEMF) have led to increasing public health concerns. However, the diagnosis and prognosis remain challenging in determination of exact dose of PFEMF exposure. MATERIALS AND METHODS: Mice were exposed to different magnetic doses of PFEMF for the following isolation of serum exosomes, microRNAs (miRNAs) extraction and small RNA sequencing. After small RNA sequencing, bioinformatic analysis and qRT-PCR validation, serum exosomal miRNA biomarkers were determined...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29229679/epigenetic-and-posttranscriptional-regulation-of-cd16-expression-during-human-nk-cell-development
#5
Aaron R Victor, Christoph Weigel, Steven D Scoville, Wing Keung Chan, Kelsey Chatman, Mary M Nemer, Charlene Mao, Karen A Young, Jianying Zhang, Jianhua Yu, Aharon G Freud, Christopher C Oakes, Michael A Caligiuri
The surface receptor FcγRIIIA (CD16a) is encoded by the FCGR3A gene and is acquired by human NK cells during maturation. NK cells bind the Fc portion of IgG via CD16a and execute Ab-dependent cell-mediated cytotoxicity, which is critical for the effectiveness of several antitumor mAb therapies. The role of epigenetic regulatory mechanisms controlling transcriptional and posttranscriptional CD16 expression in NK cells is unknown. In this study, we compared specific patterns of DNA methylation and expression of FCGR3A with FCGR3B, which differ in cell type-specific expression despite displaying nearly identical genomic sequences...
December 11, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29220380/hexokinase-2-hk2-the-tumor-promoter-in-glioma-is-downregulated-by-mir-218-bmi1-pathway
#6
Hui Liu, Nan Liu, Yingduan Cheng, Weilin Jin, Pengxing Zhang, Xin Wang, Hongwei Yang, Xiaoshan Xu, Zhen Wang, Yanyang Tu
In cancer, glycolysis driving enzymes and their regulating microRNAs are one of the key focus of oncology research lately. The glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioma, the most common malignant brain tumor. In the present study, we studied the tumorigenic role of HK2 in glioma, and clarified the mechanism of miR-218 induced HK2 regulation in glioma development. The HK2 expression in patient derived glioma and non neoplastic brain tissue was quantified. The HK2 silenced U87 and U251 cell lines were assessed for their proliferation, migration and invasive potential in vitro, while the tumor forming potential of U87 cells was evaluated in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29218085/identification-and-differential-expression-of-micrornas-in-1-25-dihydroxyvitamin-d3-induced-osteogenic-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#7
Huijie Gu, Jun Xu, Zhongyue Huang, Liang Wu, Kaifeng Zhou, Yiming Zhang, Jiong Chen, Jiangni Xia, Xiaofan Yin
The aim of this study was to identify specific microRNAs (miRNAs) and their regulatory roles in the process of 1, 25-dihydroxyvitamin D3-induced (VD3-induced) osteogenic differentiation of human adipose-derived Mesenchymal stem cells (hAMSCs). The differentially expressed miRNAs in VD3-induced hAMSCs was examined. The putative target genes of these miRNAs were predicted. A total of 76 conserved miRNAs, including 18 miRNAs were significantly up-regulated and 58 miRNAs were significantly downregulated, and significantly differentially expressed between the two samples...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29207663/microrna-218-inhibits-proliferation-and-invasion-in-ovarian-cancer-by-targeting-runx2
#8
Na Li, Lufei Wang, Guangyun Tan, Zhiheng Guo, Lei Liu, Ming Yang, Jin He
MicroRNA-218 (miR-218) has been implicated in the development and progression of multiple cancers. We investigated the role of miR-218 in ovarian cancer progression. We found that miR-218 expression levels were lower in ovarian cancer tissues and cell lines than in adjacent normal tissues or a normal ovarian cell line.miR-218 levels associated with International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis. Exogenous expression of miR-218 inhibited cell proliferation, colony formation, migration, and invasion in vitro and suppressed tumor growth in a tumor-bearing nude mouse model...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29160895/differential-expression-of-micrornas-contributed-to-the-health-efficacy-of-egcg-in-in-vitro-subarachnoid-hemorrhage-model
#9
Ying Chen, Liyong Huang, Lei Wang, Lingyun Chen, Wenhua Ren, Wenke Zhou
(-)-Epigallocatechin-3-gallate (EGCG) exhibits a broader spectrum health efficacy in subarachnoid hemorrhage (SAH) therapy; the mechanisms, however, are largely unknown. Given that miRNAs play important roles in regulation of thousands of gene expressions, the effect of EGCG on the expression of miRNAs was investigated to explore the multi-targeting actions of EGCG by using an in vitro SAH model. MTT and western blot assays were used to assess the health effects of EGCG in SAH progression; the results showed that oxyhemoglobin (OxyHb)-induced cell proliferation and excessive autophagic activation were significantly inhibited by 50 μM EGCG, but not by 1 μM EGCG...
November 21, 2017: Food & Function
https://www.readbyqxmd.com/read/29154364/non-contingent-exposure-to-amphetamine-in-adolescence-recruits-mir-218-to-regulate-dcc-expression-in-the-vta
#10
Santiago Cuesta, José Maria Restrepo-Lozano, Steven Silvestrin, Dominique Nouel, Angélica Torres-Berrio, Lauren M Reynolds, Andreas Arvanitogiannis, Cecilia Flores
The development of the dopamine input to the medial prefrontal cortex occurs during adolescence and is a process that is vulnerable to disruption by stimulant drugs such as amphetamine. We have previously linked the amphetamine-induced disruption of dopamine connectivity and prefrontal cortex maturation during adolescence to the downregulation of the Netrin-1 receptor, DCC, in dopamine neurons. However, how DCC expression in dopamine neurons is itself regulated is completely unknown. MicroRNA (miRNA) regulation of mRNA translation and stability is a prominent mechanism linking environmental events to changes in protein expression...
November 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29152130/the-association-between-polymorphisms-in-microrna-genes-and-cervical-cancer-in-a-chinese-han-population
#11
Li Chuanyin, Wang Xiaona, Yan Zhiling, Zhang Yu, Liu Shuyuan, Yang Jie, Hong Chao, Shi Li, Yang Hongying, Yao Yufeng
Several studies have confirmed the crucial roles of microRNAs (miRNAs) in cancer occurrence. In addition, single nucleotide polymorphisms (SNPs) in miRNA genes have been associated with various cancers. The aim of the present study was to investigate the association of SNPs in miRNA genes with cervical intraepithelial neoplasia (CIN) and cervical cancer in a Chinese Han population. We searched SNPs in nineteen miRNAs by sequencing healthy individuals (n=50). Then, a total of 400 patients with CIN, 609 patients with cervical cancer and 583 healthy individuals were recruited to genotype the SNPs using a Taqman assay...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29145210/diphthamide-biosynthesis-1-is-a-novel-oncogene-in-colorectal-cancer-cells-and-is-regulated-by-mir-218-5p
#12
Minghui Liu, Kai Yin, Xu Guo, Huijin Feng, Min Yuan, Yanqing Liu, Jianguo Zhang, Baoliang Guo, Chen Wang, Guangxin Zhou, Zhen Zhou, Chen-Yu Zhang, Xi Chen
BACKGROUND/AIMS: This study focused on the oncogenic role of Diphthamide biosynthesis 1 (DPH1) in colorectal cancer (CRC) cells. METHODS: The expression of DPH1 was determined by quantitative RT-PCR analysis and western blotting in CRC tissues. The role of DPH1 in CRC cells was investigated via cell viability and invasion assays under the condition of DPH1 silencing or overexpression. Bioinformatics analysis and luciferase reporter analysis were used to identify the upstream microRNA which might regulate DPH1...
November 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29138857/mir%C3%A2-218-inhibits-the-proliferation-of-human-glioma-cells-through-downregulation-of-yin-yang-1
#13
Yong Gao, Laisheng Sun, Zicheng Wu, Chengmin Xuan, Junxia Zhang, Yongping You, Xincheng Chen
Malignant glioma is the most common cancer type of the nervous system and the mechanisms driving the occurrence and development remain unclear, preventing effective treatment of this disease. Therefore, novel and efficient therapies for glioma are required. MicroRNAs (miRNAs) are small non‑coding RNAs that act as oncogenes or tumor suppressors in human cancer. In the present study, it was confirmed that Yin Yang‑1 (YY1), a transcription factor that is part of the polycomb group protein (PcG) family, is a direct target of miR‑218 in human glioma cells...
November 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29096355/the-long-non-coding-rna-malat1-interacted-with-mir-218-modulates-choriocarcinoma-growth-by-targeting-fbxw8
#14
Dazun Shi, Yu Zhang, Rong Lu, Yi Zhang
Among the first found cancer-related long non-coding RNAs (lncRNAs), MALAT1 is one that involves in the development and progression of some tumors. MALAT1 can be aberrantly expressed in hepatocellular carcinoma, cervical, breast, ovarian cancers, as well as colorectal cancer. The paper aims to make certain the function of MALAT1 in human choriocarcinoma cell lines by investigating the detailed effects and molecular mechanisms. Being specifically upregulated in choriocarcinoma cell lines, the under-researched lncRNA-MALAT1 promoted choriocarcinoma cell growth by targeting miR-218...
October 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29039590/microrna%C3%A2-218-promotes-prostaglandin-e2-to-inhibit-osteogenic-differentiation-in-synovial-mesenchymal-stem-cells-by-targeting-15%C3%A2-hydroxyprostaglandin-dehydrogenase-nad
#15
Ruijun Cong, Kun Tao, Peiliang Fu, Lieming Lou, Yuchang Zhu, Song Chen, Xinyu Cai, Lingzhou Mao
The chondrogenic differentiation of synovial mesenchymal stem cells (SMSCs) is regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process remain unclear. MicroRNAs (miRs/miRNAs) are undersized non‑coding RNAs responsible for the post‑transcriptional regulation of gene expression, by binding to the 3'‑untranslated regions (3'‑UTRs) of their target mRNAs. miRNAs may constitute a promising tool to regulate SMSC differentiation and to advance the controlled differentiation of SMSCs in therapeutic applications...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28993685/microrna-profiling-in-lung-tissue-and-bronchoalveolar-lavage-of-cigarette-smoke-exposed-mice-and-in-copd-patients-a-translational-approach
#16
Griet Conickx, Francisco Avila Cobos, Maarten van den Berge, Alen Faiz, Wim Timens, Pieter S Hiemstra, Guy F Joos, Guy G Brusselle, Pieter Mestdagh, Ken R Bracke
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation and is associated with a chronic inflammatory response in both airways and lungs. microRNAs (miRNAs) are often highly conserved between species and have an intricate role within homeostatic conditions and immune responses. Also, miRNAs are dysregulated in smoking-associated diseases. We investigated the miRNA profile of 523 miRNAs by stem-loop RT-qPCR in lung tissue and cell-free bronchoalveolar lavage (BAL) supernatant of mice exposed to air or cigarette smoke (CS) for 4 or 24 weeks...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28980049/effects-of-endogenous-hypercortisolism-on-bone-mrna-and-microrna-expression-in-humans
#17
Z E Belaya, T A Grebennikova, G A Melnichenko, A G Nikitin, A G Solodovnikov, O I Brovkina, A U Grigoriev, L Y Rozhinskaya, I I Dedov
Hypercortisolism in humans suppresses osteoblastogenesis and osteoblast function through the upregulation of Wnt-signaling antagonists (sclerostin, Dkk1) and changes in microRNAs levels (miR-125b-5p, miR-218-5p, miR-34a-5p, miR-188-3p, miR-199a-5p) which are associated with mesenchymal stem-cell commitment to adipocytes or cartilage cells over the osteoblasts. INTRODUCTION: The purpose of this study was to evaluate the responses of bone to chronic glucocorticoid (GC) excess by measuring the levels of selected mRNA and microRNA (miR) in bone samples of patients with Cushing's disease (CD)...
October 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28977866/integrative-bioinformatics-analysis-identifies-robo1-as-a-potential-therapeutic-target-modified-by-mir-218-in-hepatocellular-carcinoma
#18
Junqing Wang, Yunyun Zhou, Xiaochun Fei, Xunhua Chen, Rui Chen, Zhenggang Zhu, Yongjun Chen
Patients diagnosed with advanced hepatocellular carcinoma (HCC) presented poor prognosis and short survival time. Althouth accumulating contribution of continuous research has gradually revealed complex tumorigenesis mechanism of HCC with numerous and jumbled biomarkers, those specific ones for HCC diagnose and therapeutic treatment are required illustration. Multiple genes over-expressed in HCC specimens with at least 1.5 fold change were cohorted, compared with the non-cancerous tissues through integrative bioinformatics analysis from Gene Expression Omnibus (GEO) datasets GSE14520 and GSE6764, including 445 and 45 cases of samples spearatly, along with intensive exploration on the Cancer Genome Altas (TCGA) dataset of liver cancer...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28969058/identification-of-micrornas-as-potential-biomarkers-for-lung-adenocarcinoma-using-integrating-genomics-analysis
#19
Zhuo Peng, Longfei Pan, Zequn Niu, Wei Li, Xiaoyan Dang, Lin Wan, Rui Zhang, Shuanying Yang
Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer, but novel biomarkers for early diagnosis are lacking. Extensive effort has been exerted to identify miRNA biomarkers in LUAD. Unfortunately, high inter-lab variability and small sample sizes have produced inconsistent conclusions in this field. To resolve the above-mentioned limitations, we performed a comprehensive analysis based on LUAD miRNome profiling studies using the robust rank aggregation (RRA) method...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28946559/neat1-negatively-regulates-mir-218-expression-and-promotes-breast-cancer-progression
#20
Dahua Zhao, Ying Zhang, Nana Wang, Ning Yu
BACKGROUND: Studies have shown that lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is related to breast cancer progression, however, the role of NEAT1 remains largely unknown. The aim of the current study was to further investigate the function of NEAT1 involved in breast cancer. METHODS: QRT-PCR was used to analyze lncRNA NEAT1 expression in breast cancer tissues and determine the association between NEAT1 and clinicopathologic features in patients. Kaplan-Meier analysis and the log-rank test were used to establish the relationship between NEAT1 and overall survival...
September 7, 2017: Cancer Biomarkers: Section A of Disease Markers
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