keyword
MENU ▼
Read by QxMD icon Read
search

miR-218

keyword
https://www.readbyqxmd.com/read/28665359/estrogen-promotes-hepatic-synthesis-of-long-chain-polyunsaturated-fatty-acids-by-regulating-elovl5-at-post-transcriptional-level-in-laying-hens
#1
Meng Zhang, Cui-Cui Li, Fang Li, Hong Li, Xiao-Jun Liu, Juan J Loor, Xiang-Tao Kang, Gui-Rong Sun
The very long chain fatty acid elongase (ELOVL) plays an important role in the synthesis of long-chain polyunsaturated fatty acids (LCPUFA). Previous studies suggest that chicken could be an alternate source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study, we detected that ELOVL5, which plays a key role in the biosynthesis of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA), was highly expressed in the liver of laying hens and increased rapidly after sexual maturity...
June 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28634044/mir-218-suppresses-gastric-cancer-cell-cycle-progression-through-the-cdk6-cyclin-d1-e2f1-axis-in-a-feedback-loop
#2
Min Deng, Chao Zeng, Xihong Lu, Xiusheng He, Ruixin Zhang, Qinwei Qiu, Guopei Zheng, Xiaoting Jia, Hao Liu, Zhimin He
Studies in several cancers have suggested that miR-218 has anti-tumor activities, but its function is yet to be elucidated. In this study, we investigated the regulation and function of miR-218 (miR-218-5p) in the cell cycle progression of gastric cancer (GC). We found that miR-218 could suppress proliferation of gastric cancer cells, induce cell cycle arrest at the G1 phase and inhibit tumor growth and metastasis in vivo. We also demonstrated that miR-218 specifically targeted the 3'-UTR regions of CDK6 and cyclin D1 and inhibited the expression of these molecules, which in turn repressed the pRb/E2F1 signaling pathway...
June 17, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28631575/long-non-coding-rna-ccat1-mir-218-zfx-axis-modulates-the-progression-of-laryngeal-squamous-cell-cancer
#3
Yaming Zhang, Haili Hu
Long non-coding RNAs have been proved to be closely associated with different cancers. This study was designed to elucidate the function and mechanisms of colon cancer-associated transcript-1 in the progression of human laryngeal squamous cell cancer. Expressions of colon cancer-associated transcript-1, microRNA-218, and zinc finger protein, X-linked messenger RNA were measured using quantitative real-time polymerase chain reaction, and the expression level of zinc finger protein, X-linked protein was detected using western blot...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28615508/integrative-bioinformatics-analysis-identifies-robo1-as-a-potential-therapeutic-target-modified-by-mir-218-in-hepatocellular-carcinoma
#4
Junqing Wang, Yunyun Zhou, Xiaochun Fei, Xunhua Chen, Rui Chen, Zhenggang Zhu, Yongjun Chen
Patients diagnosed with advanced hepatocellular carcinoma (HCC) presented poor prognosis and short survival time. Althouth accumulating contribution of continuous research has gradually revealed complex tumorigenesis mechanism of HCC with numerous and jumbled biomarkers, those specific ones for HCC diagnose and therapeutic treatment are required illustration. Multiple genes over-expressed in HCC specimens with at least 1.5 fold change were cohorted, compared with the non-cancerous tissues through integrative bioinformatics analysis from Gene Expression Omnibus (GEO) datasets GSE14520 and GSE6764, including 445 and 45 cases of samples spearatly, along with intensive exploration on the Cancer Genome Altas (TCGA) dataset of liver cancer...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28598283/identification-of-micrornas-by-microarray-analysis-and-prediction-of-target-genes-involved-in-the-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells
#5
Yilin Hao, Yihong Ge, Jianjia Li, Yanwei Hu, Buling Wu, Fuchun Fang
BACKGROUND: The roles of microRNAs (miRNAs) in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) remain largely unexplored. In our study, the underlying molecular mechanism of osteogenic differentiation in hPDLSCs was investigated using miRNA profiling. METHODS: The miRNA expression profile during osteogenic differentiation was analyzed using a microarray. Target genes of miRNAs with at least a 2-fold change in expression (P value < 0...
June 9, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28598082/-expression-of-micro-rna-218-in-cervical-cancer-and-its-effect-on-proliferation-apoptosis-and-invasion-of-hela-cells
#6
Yu-Rong Shi, Jian Liu, Wei He, Yin Yang
OBJECTIVES: To investigate the expression and clinical significance of microRNA-218(miR-218)in human cervical cancer and the effects ofmiR-218 on proliferation, cell apoptosis and invasion of HeLa cells. METHODS: QRT-PCR was used to detect the expression ofmiR-218 in 23 cases of normal cervical tissues and 114 cases of cervical cancer, and the relationship between the expression and the clinicopathological features was analyzed; HeLa cells were devided into three groups: non transfection (control group), transfected with empty liposomes negative control goup (NC group), transfected with miR-218 mimic (miR-218M group)...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28589873/human-cytomegalovirus-micrornas-are-carried-by-virions-and-dense-bodies-and-are-delivered-to-target-cells
#7
Abdul-Aleem Mohammad, Helena Costa, Natalia Landázuri, Weng-Onn Lui, Kjell Hultenby, Afsar Rahbar, Koon-Chu Yaiw, Cecilia Söderberg-Nauclér
Human cytomegalovirus (HCMV) infection results in the production of virions, dense bodies (DBs) and non-infectious enveloped particles, all of which incorporate proteins and RNAs that can be transferred to host cells. Here, we investigated whether virions and DBs also carry microRNAs (miRNAs) and assessed their delivery and functionality in cells. Human lung fibroblasts (MRC-5) were infected with the HCMV strain AD169, and conditioned cell culture medium was collected and centrifuged. The pellets were treated with RNase-ONE, and the virions and DBs were purified with a potassium tartrate-glycerol gradient and dialysed...
May 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28574835/prognostic-micrornas-in-upper-tract-urothelial-carcinoma-multicenter-and-international-validation-study
#8
Laura Izquierdo, Ruth Montalbo, Mercedes Ingelmo-Torres, Carme Mallofré, Miguel Ramírez-Backhaus, Jose Rubio, Antoine G Van der Heijden, Ewout Schaafsma, Antonio Lopez-Beltran, A Blanca, Nathan Lawrentschuk, Antonio Alcaraz, Lourdes Mengual
OBJECTIVE: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. PATIENTS AND METHODS: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28558818/microrna-101a-regulates-microglial-morphology-and-inflammation
#9
Reiko Saika, Hiroshi Sakuma, Daisuke Noto, Shuhei Yamaguchi, Takashi Yamamura, Sachiko Miyake
BACKGROUND: Microglia, as well as other tissue-resident macrophages, arise from yolk sac progenitors. Thus, it is likely that the central nervous system environment is critical for the acquisition of a distinct microglial phenotype. Several microRNAs that are enriched in the brain play crucial roles in brain development and may also play a role in the differentiation of microglia. METHODS: To track the differentiation of hematopoietic cells into microglia, lineage-negative bone marrow cells were co-cultured with astrocytes in the absence or presence of microRNAs or their inhibitors...
May 30, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28549587/neuronally-differentiated-adipose-derived-stem-cells-and-aligned-phbv-nanofiber-nerve-scaffolds-promote-sciatic-nerve-regeneration
#10
Feihu Hu, Xiaofeng Zhang, Haixia Liu, Peng Xu, Doulathunnisa, Gaojun Teng, Zhongdang Xiao
Through a combination of biomaterials and stem cells, tissue engineering strategies for restoring and regenerating damaged peripheral nerves have recently been used to meet the challenges posed by nerve injury. In a previous study, we revealed a new way to induce neuronal differentiation of stem cells based on the temporally sequential use of miR-218 and Fibroblast Growth Factor 2 (FGF2) in vitro (FGF2-miR-218 induction approach). In the present study, we sought to investigate the application of this novel approach in repairing sciatic nerve damage in vivo...
May 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28492560/mir-218-5p-restores-sensitivity-to-gemcitabine-through-prkce-mdr1-axis-in-gallbladder-cancer
#11
Hui Wang, Ming Zhan, Sun-Wang Xu, Wei Chen, Man-Mei Long, Yong-Heng Shi, Qiang Liu, Man Mohan, Jian Wang
Gallbladder cancer (GBC) is one of the most common malignancy of the biliary tract characterized by its high chemoresistant tendency. Although great progresses have been made in recent decades for treating many cancers with anticancer drugs, effective therapeutics methods for anti-GBC are still lacking. Therefore, investigations into identifying the mechanisms underlying the drug resistance of GBC are greatly needed. In this study, we show that miR-218-5p plays a critical role in gemcitabine resistance of GBC...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28465350/myostatin-inhibits-osteoblastic-differentiation-by-suppressing-osteocyte-derived-exosomal-microrna-218-a-novel-mechanism-in-muscle-bone-communication
#12
Yiwen Qin, Yuanzhen Peng, Wei Zhao, Jianping Pan, Hanna Ksiezak-Reding, Christopher Cardozo, Yingjie Wu, Paola Divieti Pajevic, Lynda F Bonewald, William A Bauman, Weiping Qin
Muscle and bone are closely associated in both anatomy and function, but the mechanisms that coordinate their synergistic action remain poorly defined. Myostatin, a myokine secreted by muscles, has been shown to inhibit muscle growth, and the disruption of the myostatin gene has been reported to cause muscle hypertrophy and increase bone mass. Extracellular vesicle-exosomes that carry microRNA (miRNA), mRNA, and proteins are known to perform an important role in cell-cell communication. We hypothesized that myostatin may play a crucial role in muscle-bone interactions and may promote direct effects on osteocytes and on osteocyte-derived exosomal miRNAs, thereby indirectly influencing the function of other bone cells...
June 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28429357/inhibition-of-pulmonary-carcinoma-proliferation-or-metastasis-of-mir-218-via-down-regulating-cdcp1-expression
#13
X-J Zeng, Y-H Wu, M Luo, P-G Cong, H Yu
OBJECTIVE: Pulmonary carcinoma is one common malignant tumor with a high risk of recurrence and metastasis. Non-small cell lung cancer (NSCLC) is the most common subtype. As one tumor biomarker, microRNA (miR) has tissue sensitivity and can facilitate oncogene or inhibit tumor suppressor gene. MiR-218 has abnormal expression and can work as one molecular marker for tumors. However, its expression and function mechanism in lung cancer cells have not been fully illustrated. MATERIALS AND METHODS: In vitro cultured pulmonary adenoma A549 cells and normal bronchial epithelial cell line 16HBE were tested for miR-218 expression...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28416596/microrna-profiling-reveals-marker-of-motor-neuron-disease-in-als-models
#14
Mariah L Hoye, Erica D Koval, Amy J Wegener, Theodore S Hyman, Chengran Yang, David R O'Brien, Rebecca L Miller, Tracy Cole, Kathleen M Schoch, Tao Shen, Tomonori Kunikata, Jean-Philippe Richard, David H Gutmann, Nicholas J Maragakis, Holly B Kordasiewicz, Joseph D Dougherty, Timothy M Miller
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by the loss of motor neurons (MNs) in the brain and spinal cord, leading to fatally debilitating weakness. Because this disease predominantly affects MNs, we aimed to characterize the distinct expression profile of that cell type to elucidate underlying disease mechanisms and to identify novel targets that inform on MN health during ALS disease time course. microRNAs (miRNAs) are short, noncoding RNAs that can shape the expression profile of a cell and thus often exhibit cell-type-enriched expression...
May 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28413712/variation-within-mbp-gene-predicts-disease-course-in-multiple-sclerosis
#15
Yuan Zhou, Steve Simpson, Jac C Charlesworth, Ingrid van der Mei, Robyn M Lucas, Anne-Louise Ponsonby, Bruce V Taylor
OBJECTIVE: Prognosis following a first demyelinating event is difficult to predict, with no genetic markers of MS progression currently identified. Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating diseases such as MS. However, genetic variation in MBP has not been implicated in MS onset risk in large genome-wide association studies. We hypothesized that genetic variations in MBP may be a determinant of MS clinical course...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28412444/hypoxia-inducible-microrna-218-inhibits-trophoblast-invasion-by-targeting-lasp1-implications-for-preeclampsia-development
#16
Min Fang, Hechun Du, Bing Han, Guiyu Xia, Xiaoliang Shi, Feng Zhang, Qiqin Fu, Tao Zhang
Preeclampsia (PE) is a major contributor to maternal morbidity and mortality. However, the molecular mechanisms underlying PE progression are not well characterized. Here, we investigated the role of miR-218 in PE development. The expression of miR-218 and its host genes SLIT2 and SLIT3 was up-regulated in preeclamptic placentae compared to normal placentae. miR-218 expression was induced by hypoxia and decreased after knockdown of HIF-1α in an extravillous trophoblast cell line (HTR-8/SVneo). Chromatin immunoprecipitation assays showed direct binding of HIF-1α to the promoters of SLIT2 and SLIT3...
April 12, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28369267/mir-218-suppresses-the-metastasis-and-emt-of-hcc-cells-via-targeting-serbp1
#17
Ting Wang, Ling Xu, Rongrong Jia, Jue Wei
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. Although many efforts for treating HCC have been made, the survival rate remains unsatisfied. Accumulating evidence indicates that microRNA-218 (miR-218) functions as a tumor suppressor and involves in many biological processes such as tumor initiation, development, and metastasis in certain types of human cancers. However, the potential function and underlying molecular mechanism of miR-218 in HCC still remains to be elucidated...
May 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28323002/mir-218-inhibited-tumor-angiogenesis-by-targeting-robo1-in-gastric-cancer
#18
Xiangyuan Zhang, Jiaqiang Dong, Yan He, Ming Zhao, Zhen Liu, Na Wang, Mingzuo Jiang, Zhe Zhang, Gang Liu, Haiming Liu, Yongzhan Nie, Daiming Fan, Jun Tie
Aberrant expression of miRNAs is involved in several carcinogenic processes, including tumor growth, metastasis and angiogenesis. The aim of this study was to determine the role of miR-218 in gastric cancer angiogenesis. In situ hybridization was performed on a set of tissue microarray samples to assess the difference in miR-218 expression in vessels between tumor tissues and normal gastric mucosa. In vitro, ectopic expression of miR-218 disturbed the tubular structure and inhibited the migration of endothelial cells...
June 5, 2017: Gene
https://www.readbyqxmd.com/read/28298809/predictive-value-of-mir-219-1-mir-938-mir-34b-c-and-mir-218-polymorphisms-for-gastric-cancer-susceptibility-and-prognosis
#19
Yanhua Wu, Zhifang Jia, Donghui Cao, Chuan Wang, Xing Wu, Lili You, Simin Wen, Yuchen Pan, Xueyuan Cao, Jing Jiang
Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility...
2017: Disease Markers
https://www.readbyqxmd.com/read/28257234/reply-to-direct-detection-of-circulating-micrornas-unveiled-the-absence-of-mir-218-5p-in-smoker-subjects
#20
Griet Conickx, Pieter Mestdagh, Jo Vandesompele, Guy G Brusselle, Ken R Bracke
No abstract text is available yet for this article.
March 3, 2017: American Journal of Respiratory and Critical Care Medicine
keyword
keyword
20439
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"